|
Name |
Accession |
Description |
Interval |
E-value |
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
2-352 |
1.19e-99 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 298.45 E-value: 1.19e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 2 NKETIlSRQILTYMLLLTFVIIAIAILGSYLFYSFLIY--YLPGGMNEGSEDAMTFLDWMWILMASITSLVVALFFTVKL 79
Cdd:NF012226 2 NKSGI-SKQLFIALSIVNLSVTLFSVFLGYFIYNYAIEvgWITLSSLQEDWTEFHFVDWIWLFTVILCGSVISLIIGMKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 80 SARIFNPLNDVAYSLKQISQGNLSARAFNSSSKLGEMNRLVNDFNEMAEKLQTLDAQRNLWNAAIAHELRTPVTILRGRL 159
Cdd:NF012226 81 AQRFIVPINFLADAAKKISQGDLSARAEDSQIHSAEISELMHNFNDMAQKLESSVKNAQVWNAAIAHELRTPITILQGRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 160 QGLVDGVFEPEPSLFRNLLKQTEGLTNLIEDLRVVSSSGGAGYSLMLSEVDLKATISNALDTFWPDFDKKHFKIVTEINQ 239
Cdd:NF012226 161 QGILDGVFEPDPALFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLKMFEDRLEQAQLTIVLNLTA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 240 QYCVCDPLRIIQCLTVLFDNALKYSTSQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGL 319
Cdd:NF012226 241 TPVFCDRRRIEQVLIALIDNAIRYANAGKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGL 320
|
330 340 350
....*....|....*....|....*....|...
gi 490288705 320 GLSVVKAIMCAHGGDVSYSlTPENGSLFKLSWP 352
Cdd:NF012226 321 GLAVVHAIVIAHKGSIEYS-NSQGNSVFTIKLP 352
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
124-353 |
6.27e-53 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 174.71 E-value: 6.27e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 124 NEMAEKLQTLDAQRNLWNAAIAHELRTPVTILRGRLQGLVDGVFEPEPS---LFRNLLKQTEGLTNLIEDLRVVSSSGGA 200
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEErreLLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 201 GYSLMLSEVDLKATISNALDTFWPDFDKKHFKIVTEINQQ--YCVCDPLRIIQCLTVLFDNALKYSTSQ-TLLIKNGITG 277
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElpLVYADPELLEQVLANLLDNAIKYSPPGgTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490288705 278 NDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNInpEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
6-353 |
2.05e-50 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 172.81 E-value: 2.05e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 6 ILSRQILTYMLLLTFVIIAIAILGSYLFYSFLIYYLPGGMNEGSEDAMTFLDWMWILMASITSLVVALFFTVKLSARIFN 85
Cdd:COG5002 24 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 86 PLNDVAYSLKQISQGNLSARAFNSSSKLGEMNRLVNDFNEMA----------EKLQTLDAQRNLWNAAIAHELRTPVTIL 155
Cdd:COG5002 104 LLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLlllaaverdiTELERLEQMRREFVANVSHELRTPLTSI 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 156 RGRLQGLVDGVFEPEP---SLFRNLLKQTEGLTNLIEDLRVVSSSGGAGYSLMLSEVDLKATISNALDTFWPDFDKKHFK 232
Cdd:COG5002 184 RGYLELLLDGAADDPEerrEYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIE 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 233 IVTEINQQ--YCVCDPLRIIQCLTVLFDNALKYS-TSQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYA 309
Cdd:COG5002 264 LELDLPEDplLVLGDPDRLEQVLTNLLDNAIKYTpEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKS 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 490288705 310 KNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:COG5002 344 RSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
32-353 |
1.15e-48 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 166.62 E-value: 1.15e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 32 LFYSFLIYYLPGGMNEGSEDAMTFLDWMWILMASITSLVVALFFTVKLSARIFNPLNDVAYSLKQISQGNLSARAFNSSS 111
Cdd:COG0642 5 LLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 112 KLGEMNRLVNDFNEMAEKLQTLDAQRNLWNAAIAHELRTPVTILRGRLQGLVDGVFEPEPSLFRNLLKQTEGLTNLIEDL 191
Cdd:COG0642 85 LLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLINDL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 192 RVVSSSGGAGYSLMLSEVDLKATISNALDTFWPDFDKKHFKIVTEINQQ--YCVCDPLRIIQCLTVLFDNALKYSTS-QT 268
Cdd:COG0642 165 LDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDlpTVRGDPDRLRQVLLNLLSNAIKYTPEgGT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 269 LLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEyaKNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFK 348
Cdd:COG0642 245 VTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFT 322
|
....*
gi 490288705 349 LSWPV 353
Cdd:COG0642 323 VTLPL 327
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
55-353 |
7.22e-38 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 140.51 E-value: 7.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 55 FLDWM-WILMASITSLVVALFFTVKLSARifnPLNDVAYSLKQISQ----GNLSARA-FNSSSKLGemnRLVNDFNEMAE 128
Cdd:PRK10604 130 YLHQMrLLDIALLALIGLSLAFPVFLWMR---PHWQDMLKLEAAAQrlgdGHLAERIhFDEGSSLE---RLGVAFNQMAD 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 129 KLQTLDAQRNLWNAAIAHELRTPVTILRGRLQgLVDGVFEPEPSLFRNLLKQTEGLtnlIEDLRVVSSSGGAGYSLMLSE 208
Cdd:PRK10604 204 NINALIASKKQLIDGIAHELRTPLVRLRYRLE-MSDNLSAAESQALNRDIGQLEAL---IEELLTYARLDRPQNELHLSE 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 209 VDLKATISNALDTFWPDFDKKHFKIVTEINQQYCVCDPLRIIQCLTVLFDNALKYSTsQTLLIKNGITGNDNFIIVQDQG 288
Cdd:PRK10604 280 PDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAH-SRVRVSLLLDGNQACLIVEDDG 358
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490288705 289 PGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:PRK10604 359 PGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
60-352 |
1.60e-37 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 139.96 E-value: 1.60e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 60 WILMAsiTSLVVALFFTVKLSARIFNPLNDVAYSLKQISQGNLSARAFNSSSKlgEMNRLVNDFNEMAEKLQTLDAQRNL 139
Cdd:NF012163 167 WLIVA--LALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSND--ELGKLAQDFNQLASTLEKNEQMRRD 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 140 WNAAIAHELRTPVTILRGRLQGLVDGVFEPEPSLFRNLLKQTEGLTNLIEDLRVVSSSGGAGYSLMLSEVDLKATISNAL 219
Cdd:NF012163 243 FMADISHELRTPLAVLRAELEAIQDGIRKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEG 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 220 DTFWPDFDKKHFKIVTEI-NQQYCVCDPLRIIQCLTVLFDNALKYS-TSQTLLIKNGITGNDNFIIVQDQGPGIPEELQK 297
Cdd:NF012163 323 GAFRERFASAGLELEVSLpDSSLVFGDRDRLMQLFNNLLENSLRYTdSGGSLHISASQRPKEVTLTVADSAPGVSDEQLA 402
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 490288705 298 SLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWP 352
Cdd:NF012163 403 RLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
60-333 |
1.37e-34 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 132.06 E-value: 1.37e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 60 WILMASITSLvvALFFTVKLSARIFNPLNDVAYSLKQISQGNLSARAFNSSSKlgEMNRLVNDFNEMAEKLQTLDAQRNL 139
Cdd:PRK10549 167 WLIVALSTLL--AALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRD--ELGRLAQDFNQLASTLEKNEQMRRD 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 140 WNAAIAHELRTPVTILRGRLQGLVDGVFEPEPSLFRNLLKQTEGLTNLIEDLRVVSSS--GGAGYSLMLseVDLKATISN 217
Cdd:PRK10549 243 FMADISHELRTPLAVLRGELEAIQDGVRKFTPESVASLQAEVGTLTKLVDDLHQLSLSdeGALAYRKTP--VDLVPLLEV 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 218 ALDTFWPDFDKKHFKIVTEINQQYCV-CDPLRIIQCLTVLFDNALKYSTSQ-TLLIKNGITGNDNFIIVQDQGPGIPEEL 295
Cdd:PRK10549 321 AGGAFRERFASRGLTLQLSLPDSATVfGDPDRLMQLFNNLLENSLRYTDSGgSLHISAEQRDKTLRLTFADSAPGVSDEQ 400
|
250 260 270
....*....|....*....|....*....|....*...
gi 490288705 296 QKSLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGG 333
Cdd:PRK10549 401 LQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNG 438
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
55-352 |
8.63e-32 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 124.04 E-value: 8.63e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 55 FLDWMWILMASITSLVVAL-FFTVKLSARifnPLNDVAYSLKQISQGNLSARaFNSSSKLGEMNRLVNDFNEMAEKLQtl 133
Cdd:TIGR01386 162 LRKWLILIAVLLVLLTALLgWWITRLGLE---PLRRLSAVAARISPESLDQR-LDPSRAPAELRELAQSFNAMLGRLE-- 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 134 DAQRNL--WNAAIAHELRTPVTILRGRLQGLVD---GVFEPEPSLFRNLlKQTEGLTNLIEDLRVVSSSGGAGYSLMLSE 208
Cdd:TIGR01386 236 DAFQRLsqFSADLAHELRTPLTNLLGQTQVALSqprTGEEYREVLESNL-EELERLSRMVSDMLFLARADNGQLALERVR 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 209 VDLKATISNALDTFWPDFDKKHFKIVTEINQQyCVCDPLRIIQCLTVLFDNALKYSTS-QTLLIKNGITGNDNFIIVQDQ 287
Cdd:TIGR01386 315 LDLAAELAKVAEYFEPLAEERGVRIRVEGEGL-VRGDPQMFRRAISNLLSNALRHTPDgGTITVRIERRSDEVRVSVSNP 393
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490288705 288 GPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGDVSYSlTPENGSLFKLSWP 352
Cdd:TIGR01386 394 GPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAE-SPDGKTRFILRFP 457
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
61-353 |
8.23e-31 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 120.84 E-value: 8.23e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 61 ILMASITSLVVALFFTVKLSARIFNPLNDVAYSLKQISQGNLSARAFNSSSKlgEMNRLVNDFNEMAEKLQT----LDAQ 136
Cdd:COG5000 11 LLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDD--EIGELARAFNRMTDQLKEqreeLEER 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 137 RN-----------------------LWNAA-------------------------------------------------- 143
Cdd:COG5000 89 RRyletilenlpagvivldadgritLANPAaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgrr 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 144 ---------------------------------------IAHELRTPVTILRG---RLQGLVDGVFEPEPSLFRNLL--- 178
Cdd:COG5000 169 tllvrasplrddgyvivfdditellraerlaawgelarrIAHEIKNPLTPIQLsaeRLRRKLADKLEEDREDLERALdti 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 179 -KQTEGLTNLIEDLRVVSSSGgagySLMLSEVDLKATISNALDTFWPDFDKKHFKIVTEINQQ--YCVCDPLRIIQCLTV 255
Cdd:COG5000 249 iRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDlpEVLADRDQLEQVLIN 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 256 LFDNALK-YSTSQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQ--RgeyakninPEGCGLGLSVVKAIMCAHG 332
Cdd:COG5000 325 LLKNAIEaIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFttK--------PKGTGLGLAIVKKIVEEHG 396
|
410 420
....*....|....*....|.
gi 490288705 333 GDVSYSLTPENGSLFKLSWPV 353
Cdd:COG5000 397 GTIELESRPGGGTTFTIRLPL 417
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
142-353 |
4.66e-28 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 112.20 E-value: 4.66e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 142 AAIAHELRTPVTILRGRLQGL---VDGVFEPE--PSLFRNLLKQTEGLTNLIEDLRVVSSSGgagySLMLSEVDLKATIS 216
Cdd:COG4191 147 AGIAHEINNPLAAILGNAELLrrrLEDEPDPEelREALERILEGAERAAEIVRSLRAFSRRD----EEEREPVDLNELID 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 217 NALDTFWPDFDKKHFKIVTEINQQ--YCVCDPLRIIQCLTVLFDN---ALKYSTSQTLLIKNGITGNDNFIIVQDQGPGI 291
Cdd:COG4191 223 EALELLRPRLKARGIEVELDLPPDlpPVLGDPGQLEQVLLNLLINaidAMEEGEGGRITISTRREGDYVVISVRDNGPGI 302
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490288705 292 PEELQKSLFQPF----QRGEyakninpeGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:COG4191 303 PPEVLERIFEPFfttkPVGK--------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
66-353 |
1.15e-25 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 106.92 E-value: 1.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 66 ITSLVVA---LFftvklsARIFN-PLNDVAYSLKQISQGNLSA--RAFNSSsklgEMNRLVNDFNEMAEKLQTLDAQRNL 139
Cdd:PRK09467 162 IGLLSVAggwLF------IRIQNrPLVALEHAALQVGKGEIPPplREYGAS----EVRSVTRAFNQMAAGIKQLEDDRTL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 140 WNAAIAHELRTPVTilRGRL---------QGLVDG-VFEPEP-----SLFRNLLKQTEG-------LTNLIEDlrVVSSS 197
Cdd:PRK09467 232 LMAGVSHDLRTPLT--RIRLatemmseedGYLAESiNKDIEEcnaiiEQFIDYLRTGQEmpmemadLNALLGE--VIAAE 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 198 GGAGYSLmlsEVDLKATISNALdtfwpdfdkkhfkivteinqqycvCDPLRIIQCLTVLFDNALKYSTSQtLLIKNGITG 277
Cdd:PRK09467 308 SGYEREI---ETALQPGPIEVP------------------------MNPIAIKRALANLVVNAARYGNGW-IKVSSGTEG 359
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490288705 278 NDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKniNPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:PRK09467 360 KRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSAR--GSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
245-353 |
2.63e-24 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 95.79 E-value: 2.63e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 245 DPLRIIQCLTVLFDNALKYSTSQ-TLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEyAKNINPEGCGLGLSV 323
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGgRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|
gi 490288705 324 VKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
143-353 |
7.70e-24 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 102.17 E-value: 7.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 143 AIAHELRTPvtiLRGrLQGLVD-------GVFEPE-PSLFRNLLKQTEGLTNLIEDLRVVSSSGGAGysLMLSEVDLKAT 214
Cdd:COG4251 288 VASHDLREP---LRK-ISGFSQlleedygDKLDEEgREYLERIRDAAERMQALIDDLLAYSRVGRQE--LEFEPVDLNEL 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 215 ISNALDTFWPDFDKKHFKIVTEiNQQYCVCDPLRIIQCLTVLFDNALKYSTS-QTLLIKNGITGNDNF--IIVQDQGPGI 291
Cdd:COG4251 362 LEEVLEDLEPRIEERGAEIEVG-PLPTVRGDPTLLRQVFQNLISNAIKYSRPgEPPRIEIGAEREGGEwvFSVRDNGIGI 440
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490288705 292 PEELQKSLFQPFQR----GEYakninpEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:COG4251 441 DPEYAEKIFEIFQRlhsrDEY------EGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
245-353 |
8.31e-22 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 88.96 E-value: 8.31e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 245 DPLRIIQCLTVLFDNALKYSTSQ---TLLIKngiTGNDNFIIVQDQGPGIPEELQKSLFQPFQRgeyAKNINPEGCGLGL 321
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAgeiTVTLS---EGGELTLTVEDNGIGIPPEDLPRIFEPFST---ADKRGGGGTGLGL 75
|
90 100 110
....*....|....*....|....*....|..
gi 490288705 322 SVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:pfam02518 76 SIVRKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
115-353 |
2.02e-21 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 93.86 E-value: 2.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 115 EMNRLVNDFNEMAEKLQTLDaqRNLwnAAIAHELRTPVTILRGRLQ----GLVDGVFEPEPSLFRNLL----KQTEGLTN 186
Cdd:PRK09303 133 ELFVLRQENETLLEQLKFKD--RVL--AMLAHDLRTPLTAASLALEtlelGQIDEDTELKPALIEQLQdqarRQLEEIER 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 187 LIEDLRVVSSSGGAGYSLMLSEVDLKATISNALDTFWPDFDKKHFKIVTEINQQY-CV-CDPLRIIQCLTVLFDNALKYS 264
Cdd:PRK09303 209 LITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLpSVyADQERIRQVLLNLLDNAIKYT 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 265 -------------TSQTLLIkngitgndnfiIVQDQGPGIPEELQKSLFQP---FQRGEYAkninpEGCGLGLSVVKAIM 328
Cdd:PRK09303 289 peggtitlsmlhrTTQKVQV-----------SICDTGPGIPEEEQERIFEDrvrLPRDEGT-----EGYGIGLSVCRRIV 352
|
250 260
....*....|....*....|....*
gi 490288705 329 CAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:PRK09303 353 RVHYGQIWVDSEPGQGSCFHFTLPV 377
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
249-351 |
1.58e-20 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 84.96 E-value: 1.58e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 249 IIQCLTVLFDNALKYSTSQTLLIKNGITGNDNF-IIVQDQGPGIPEELQKSLFQPFQRGEYAKNInpEGCGLGLSVVKAI 327
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVvLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 490288705 328 MCAHGGDVSYSLTPENGSLFKLSW 351
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-353 |
1.64e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 85.17 E-value: 1.64e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 256 LFDNALKYSTSqTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGDV 335
Cdd:cd16939 8 LLRNALRYAHR-TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALWHGGHV 86
|
90
....*....|....*...
gi 490288705 336 SYSLTPENGSLFKLSWPV 353
Cdd:cd16939 87 ECDDSELGGACFRLTWPR 104
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
129-348 |
2.52e-20 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 90.35 E-value: 2.52e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 129 KLQTLDAQRNLWNAAIAHELRTPVTILRGRLQGLVDGVFEPEPSL---FRNLLKQTEGLTNLIEDLRVVSSSGGAGYSLM 205
Cdd:TIGR02966 106 RLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWnraLEIMLEQSQRMQSLVEDLLTLSRLESAASPLE 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 206 LSEVDLKATISNALDTFWPDFDKKHFKIVTEINQQYCVC-DPLRIIQCLTVLFDNALKYSTSQ-TLLIKNGITGNDNFII 283
Cdd:TIGR02966 186 DEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLgDEDELRSAFSNLVSNAIKYTPEGgTITVRWRRDGGGAEFS 265
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490288705 284 VQDQGPGI-PEELQKsLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFK 348
Cdd:TIGR02966 266 VTDTGIGIaPEHLPR-LTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGSTFS 330
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
127-353 |
4.27e-20 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 89.91 E-value: 4.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 127 AEKLQTLdaqRNLwnAA-IAHELRTPVTILRGRLQGLVDGVFEPE-PSLFRNLLKQTEGLTNLIEDLRVVSSSGgagySL 204
Cdd:COG3852 129 AEKLAAV---GEL--AAgLAHEIRNPLTGIRGAAQLLERELPDDElREYTQLIIEEADRLNNLVDRLLSFSRPR----PP 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 205 MLSEVDLKATISNALDTFWPDFDKkHFKIVTEINQQ--YCVCDPLRIIQCLTVLFDNA---------LKYSTSQTLLIKN 273
Cdd:COG3852 200 EREPVNLHEVLERVLELLRAEAPK-NIRIVRDYDPSlpEVLGDPDQLIQVLLNLVRNAaeampeggtITIRTRVERQVTL 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 274 GITGNDNF--IIVQDQGPGIPEELQKSLFQPFQRGeyaKninPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSW 351
Cdd:COG3852 279 GGLRPRLYvrIEVIDNGPGIPEEILDRIFEPFFTT---K---EKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
|
..
gi 490288705 352 PV 353
Cdd:COG3852 353 PL 354
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
137-353 |
6.80e-20 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 91.25 E-value: 6.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 137 RNLWNAAIAHELRTPVTILRGRLQGL-VDGVFE-----PEPSLFR-NLLKQTEGLTNLIEDLRVVSssggAGYSLMLSEV 209
Cdd:PRK10490 664 RNALLAALSHDLRTPLTVLFGQAEILtLDLASEgsphaRQASEIRqQVLNTTRLVNNLLDMARIQS----GGFNLRKEWL 739
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 210 DLKATISNALDTFWPDFDKKHFKIVTEINQQYCVCDPLRIIQCLTVLFDNALKYSTSQTLL-IKNGITGNDNFIIVQDQG 288
Cdd:PRK10490 740 TLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIgIDAHVEGERLQLDVWDNG 819
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490288705 289 PGIPEELQKSLFQPFQRGEYAKNInPeGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:PRK10490 820 PGIPPGQEQLIFDKFARGNKESAI-P-GVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPL 882
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
142-353 |
5.41e-19 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 87.72 E-value: 5.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 142 AAIAHELRTPVTILRGRLQGLVDGVFEPEPSLFRNLLKQTEGLTNLIEDLRVVSSSGgagySLMLSEVDLKATISNALDT 221
Cdd:COG5809 275 AGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQ----AIKYEPKDLNTLIEEVIPL 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 222 FWPDFDKKHFKIVTEINQQ--YCVCDPLRIIQCLTVLFDNALKYSTSQ-TLLIKNGITGNDNFII-VQDQGPGIPEELQK 297
Cdd:COG5809 351 LQPQALLKNVQIELELEDDipDILGDENQLKQVFINLLKNAIEAMPEGgNITIETKAEDDDKVVIsVTDEGCGIPEERLK 430
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 490288705 298 SLFQPF-QRGEyakninpEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:COG5809 431 KLGEPFyTTKE-------KGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPI 480
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
61-352 |
1.32e-18 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 86.75 E-value: 1.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 61 ILMASITSLVValFFTVKLSARI-FNPLNDVAYSLKQISQGNLSARAFNSSSKLgEMNRLVNDFNEMAEKLQTLDAQRNL 139
Cdd:PRK09835 188 IMTASVISLLI--VFIVLLAVHKgHAPIRSVSRQIQNITSKDLDVRLDPQTVPI-ELEQLVLSFNHMIERIEDVFTRQSN 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 140 WNAAIAHELRTPVTIL---------RGRLQGlvdgvfEPEPSLFRNLlKQTEGLTNLIEDLRVVSSSGGAgySLMLSEV- 209
Cdd:PRK09835 265 FSADIAHEIRTPITNLitqteialsQSRSQK------ELEDVLYSNL-EELTRMAKMVSDMLFLAQADNN--QLIPEKKm 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 210 -DLKATISNALDTFWPDFDKKHfkIVTEINQQYCVC--DPLRIIQCLTVLFDNALKYSTS-QTLLIKNGITGNDNFIIVQ 285
Cdd:PRK09835 336 lDLADEVGKVFDFFEAWAEERG--VELRFVGDPCQVagDPLMLRRAISNLLSNALRYTPAgEAITVRCQEVDHQVQLVVE 413
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490288705 286 DQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPEnGSLFKLSWP 352
Cdd:PRK09835 414 NPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDAR-GTRFVISLP 479
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
111-353 |
2.60e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 86.50 E-value: 2.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 111 SKLGEMNRLVNDFNEMAEKLQTLDAQRNLWNAAIAHELRTPVTILRGRLQGLVDgvfEPEPSLFRNLLKQT----EGLTN 186
Cdd:PRK11466 418 ARTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD---NPALNAQRDDLRAItdsgESLLT 494
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 187 LIEDLRVVSSSGGAGYSLMLSE--VDLKATISNALDTFWPDFDKKHFKIVTEINQQ---YCVCDPLRIIQCLTVLFDNAL 261
Cdd:PRK11466 495 ILNDILDYSAIEAGGKNVSVSDepFEPRPLLESTLQLMSGRVKGRPIRLATDIADDlptALMGDPRRIRQVITNLLSNAL 574
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 262 KYSTSQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPF-----QRGeyakninpeGCGLGLSVVKAIMCAHGGDVS 336
Cdd:PRK11466 575 RFTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFvqvsgKRG---------GTGLGLTISSRLAQAMGGELS 645
|
250
....*....|....*..
gi 490288705 337 YSLTPENGSLFKLSWPV 353
Cdd:PRK11466 646 ATSTPEVGSCFCLRLPL 662
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
127-353 |
1.51e-17 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 83.86 E-value: 1.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 127 AEKLQTLDAqrnlWNAAIAHELRTPVTILRGRLQGLVDGVFEPEPSLFRNL-LKQTEGLTNLIEDLRVVSSSGGAgyslM 205
Cdd:PRK11360 384 QERLAALGE----LVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVvLREVDRLNKVIDQLLEFSRPRES----Q 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 206 LSEVDLKATISNALDTFWPDFDKKHFKIVTEINQQY--CVCDPLRIIQCLTVLFDNALK-YSTSQTLLIKNGITGNDN-F 281
Cdd:PRK11360 456 WQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELppIWADPELLKQVLLNILINAVQaISARGKIRIRTWQYSDGQvA 535
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490288705 282 IIVQDQGPGIPEELQKSLFQPFqrgeyaKNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:PRK11360 536 VSIEDNGCGIDPELLKKIFDPF------FTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
245-352 |
2.58e-17 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 76.76 E-value: 2.58e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 245 DPLRIIQCLTVLFDNALKYSTSQTLL--IKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLS 322
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIrcILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 490288705 323 VVKAIMCAHGGDVSYSLTPENGSLFKLSWP 352
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
259-352 |
3.41e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 76.21 E-value: 3.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 259 NALKYStSQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGDVSYS 338
Cdd:cd16949 11 NALRYS-PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIEQHGGKIKAS 89
|
90
....*....|....
gi 490288705 339 LTPENGSLFKLSWP 352
Cdd:cd16949 90 NRKPGGLRVRIWLP 103
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
59-352 |
4.36e-17 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 82.48 E-value: 4.36e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 59 MWILMASITSLVVALFFTVKLSARIFNPLNDVAYSLKQisQGNLSARaFNSSSKLGEMNRLVNDFNEMAEKLQTLDAQRN 138
Cdd:TIGR03785 410 NVILAIMSIGTLALFGFASWISWRIRRLSDDAEAAIDS--QGRISGA-IPASRSRDEIGDLSRSFAQMVARLRQYTHYLE 486
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 139 LWNAAIAHELRTPVTILRGRLQGLVDGVFEPEPSLFrnLLKQTEG-------LTNLIEDLRVVSSSGGAGyslmLSEVDL 211
Cdd:TIGR03785 487 NMSSRLSHELRTPVAVVRSSLENLELQALEQEKQKY--LERAREGterlsmiLNNMSEATRLEQAIQSAE----VEDFDL 560
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 212 KATISNALDTFWPDFdkKHFKIVTEINQQYCVCD--PLRIIQCLTVLFDNALKYSTSQTlLIKNGITGNDN--FIIVQDQ 287
Cdd:TIGR03785 561 SEVLSGCMQGYQMTY--PPQRFELNIPETPLVMRgsPELIAQMLDKLVDNAREFSPEDG-LIEVGLSQNKShaLLTVSNE 637
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490288705 288 GPGIPEELQKSLFQPF--QRGEYAKNInpEGCGLGLSVVKAIMCAHGGDVSYSLTPEN-GSLFKLSWP 352
Cdd:TIGR03785 638 GPPLPEDMGEQLFDSMvsVRDQGAQDQ--PHLGLGLYIVRLIADFHQGRIQAENRQQNdGVVFRISLP 703
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
61-353 |
1.73e-16 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 80.27 E-value: 1.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 61 ILMASITSLVVALFFTVKLSARIFNPLNDVAYSLKQISQGNLSARAFNSSSKLGEMNRLVNdfnEMAEKL---------- 130
Cdd:PRK11100 184 ILWAGALLLGIALLIGAGVVWWLNRSIRRLTRYADAVTEGKPVPLPKLGSSELRELAQALE---SMRVKLegkayveqyv 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 131 QTLdaqrnlwnaaiAHELRTPVTILRGR---LQGlvdgvfEPEP----SLFRNLLKQTEGLTNLIEDLrvvsssggagys 203
Cdd:PRK11100 261 QTL-----------THELKSPLAAIRGAaelLQE------DPPPedraRFTGNILTQSARLQQLIDRL------------ 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 204 LMLSE------------VDLKATISNALDTFWPDFDKKHFKIVTEINQQYCVCDPLRIIQCLTVLFDNALKYSTSQ-TLL 270
Cdd:PRK11100 312 LELARleqrqelevlepVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGgTIT 391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 271 IKNGITGNDNFIIVQDQGPGIPEELQKSLFQPF---QRGEYAKninpEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLF 347
Cdd:PRK11100 392 LSAEVDGEQVALSVEDQGPGIPDYALPRIFERFyslPRPANGR----KSTGLGLAFVREVARLHGGEVTLRNRPEGGVLA 467
|
....*.
gi 490288705 348 KLSWPV 353
Cdd:PRK11100 468 TLTLPR 473
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
61-352 |
1.43e-15 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 77.37 E-value: 1.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 61 ILMASITSLVVALFFTvklsarifnPLNDVAYSLKQISQGNLSARAFNSSSKlgEMNRLVNDFNEMAEKLQ-TLDAQRNL 139
Cdd:NF040691 199 VLLGLIAWLVTRQVVA---------PVRSAARTAERFAAGDLSERMPVKGED--DLARLARSFNQMADSLQrQIRQLEEL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 140 WNAA------IAHELRTPVTILRGRLQGLVDGVFEPEPSLFRN---LLKQTEGLTNLIEDLRVVSSSGGAGYSLMLSEVD 210
Cdd:NF040691 268 SRLQqrfvsdVSHELRTPLTTIRMAADVIHDSRDDFDPATARSaelLHTELDRFESLLSDLLEISRFDAGAAELDVEPVD 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 211 LKATISNALDTFWPDFDKKHFKIVTEINQQYCVC--DPLRIIQCLTVLFDNALKYSTSQTLLIKNGITGNDNFIIVQDQG 288
Cdd:NF040691 348 LRPLVRRVVDALRQLAERAGVELRVDAPGTPVVAevDPRRVERVLRNLVVNAIEHGEGKPVVVTVAQDDTAVAVTVRDHG 427
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490288705 289 PGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWP 352
Cdd:NF040691 428 VGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
131-334 |
2.25e-15 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 77.10 E-value: 2.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 131 QTLDAQRNLWNAAIAHELRTPVTILRGRLQGLVDGVFEpEPSLFRNLLK----QTEGLTNLIEDLRVVSSSGGAGYSLML 206
Cdd:NF033092 366 EKIEQERREFVANVSHELRTPLTTMRSYLEALADGAWK-DPELAPRFLGvtqnETERMIRLVNDLLQLSRMDSKDYKLNK 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 207 SEVDLKATISNALDTFwpDFD--KKHFKIVTEINQQ--YCVCDPLRIIQCLTVLFDNALKYS----TsqtllIKNGITGN 278
Cdd:NF033092 445 EWVNFNEFFNYIIDRF--EMIlkNKNITFKREFPKRdlWVEIDTDKITQVLDNIISNAIKYSpeggT-----ITFRLLET 517
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 490288705 279 DNFII--VQDQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGD 334
Cdd:NF033092 518 HNRIIisISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGR 575
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-335 |
9.28e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 69.40 E-value: 9.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 256 LFDNALKYStSQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNINpeGCGLGLSVVKAIMCAHGGDV 335
Cdd:cd16950 8 LVDNALRYG-GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTS--GTGLGLAIVQRISDAHGGSL 84
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
245-352 |
1.12e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 69.41 E-value: 1.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 245 DPLRIIQCLTVLFDNALKYS-TSQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSV 323
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTdTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 490288705 324 VKAIMCAHGGDVSYSLTPENGSLFKLSWP 352
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
264-352 |
4.58e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 67.42 E-value: 4.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 264 STSQTLLIKNGITGNDNFII-VQDQGPGIPEELQKSLFQPFQrgeyakNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPE 342
Cdd:cd16920 21 CERRELTIRTSPADDRAVTIsVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSICRSIIEAHGGRLSVESPAG 94
|
90
....*....|
gi 490288705 343 NGSLFKLSWP 352
Cdd:cd16920 95 GGATFQFTLP 104
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
249-353 |
4.60e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 67.52 E-value: 4.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 249 IIQCLTVLFDNALKYSTSQTLLIK---NGITGNDNFII--VQDQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSV 323
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTLRvslEEEEEDGVQLRfsVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 490288705 324 VKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
57-337 |
4.64e-14 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 72.57 E-value: 4.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 57 DWMWILMASITSLVVALFFTVklsARIFNPLNDVAYSLKQISQGNLsaRAFNSSSKLGEMNRLVNDFNEMAEKLQTLDAQ 136
Cdd:NF038389 131 YYIIVFFIFLILLLLILYISV---LKSLKPLKKLKKQIKKFANGDF--DFIKSESNGDEIGEVANEFDKAVKKIKALNES 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 137 RNLWNAAIAHELRTPVTilRGRLqglvdgVFE-PEPSLFRNLLKQT-EGLTNLIEDL----RVVSSSggagYSLMLSEVD 210
Cdd:NF038389 206 RQLFLRNIMHELKTPIT--KGRI------VAEmLEDEKQKERLISIfERLESLINEFakieQLTSKN----YKLNKKEYR 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 211 LKATISNALDTFWpdFDKKHFKIVTEINQqycvcdplRIIQCLTVLF--------DNALKYSTSQTLLIKNgitgNDNFI 282
Cdd:NF038389 274 LSDIIDEAIDMLM--IDDSSVIIKVSLED--------FKLNVDFELFslaiknliDNAIKYSPDKKVTIEI----KGDKI 339
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 490288705 283 IVQDQGPGIPEELQKsLFQPFQRGeyaKNINPEGCGLGLSVVKAIMCAHGGDVSY 337
Cdd:NF038389 340 EFKNKGEPLEEPLEY-YFEPFFKG---NEKSKSGFGLGLYIVKNILKAHGFKLEY 390
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
245-351 |
1.33e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 66.28 E-value: 1.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 245 DPLRIIQCLTVLFDNALKYSTSQT---LLIKNGITGNdnfIIVQDQGPGIPEELQKSLFQPFQRgeyAKNINPEGCGLGL 321
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSrveIKLSADDGAV---IRVEDNGPGIDEEELEALFERFYR---SDGQNYGGSGLGL 83
|
90 100 110
....*....|....*....|....*....|
gi 490288705 322 SVVKAIMCAHGGDVSYSLTPENGSLFKLSW 351
Cdd:cd16940 84 SIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
123-335 |
5.16e-13 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 69.58 E-value: 5.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 123 FNEMAEKLQTL-DAQRNLWnAAIAHELRTPVTILR------GRLQGlvdgvfepEPSLFRNLLKQTEGLTNLIEDLrvvs 195
Cdd:PRK09470 229 FNQMVTALERMmTSQQRLL-SDISHELRTPLTRLQlatallRRRQG--------ESKELERIETEAQRLDSMINDL---- 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 196 ssggagysLMLSEVDLKATISN---ALDTFWPD------FD----KKHFKIVTEINQQYCVCDPLRIIQCLTVLFDNALK 262
Cdd:PRK09470 296 --------LVLSRNQQKNHLERetfKANSLWSEvledakFEaeqmGKSLTVSAPPGPWPINGNPNALASALENIVRNALR 367
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490288705 263 YSTSQ-TLLIKngITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGDV 335
Cdd:PRK09470 368 YSHTKiEVAFS--VDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWV 439
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
246-353 |
6.18e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 64.37 E-value: 6.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 246 PLRIIQCLTVLFDNALK-YSTSQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFqrgeYAKNINPEGCGLGLSVV 324
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQaMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPF----FTTKPVGEGTGLGLSLS 76
|
90 100
....*....|....*....|....*....
gi 490288705 325 KAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
122-353 |
1.23e-12 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 68.99 E-value: 1.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 122 DFNEMAEKLQTLDAQRN-LWNAAIA---------HELRTPVTILRGRLQGLVDGVFEPEPSLFRNLLKQTEG--LTNLIE 189
Cdd:PRK09959 687 DITETRDLIHALEVERNkAINATVAksqflatmsHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGqsLLGLIG 766
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 190 DLRVVSSSGGAGYSLMLSEVDLKATISNALDTFWPDFDKKHFKIV--TEINQQYCV-CDPLRIIQCLTVLFDNALKYSTS 266
Cdd:PRK09959 767 EILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALScsSTFPDHYLVkIDPQAFKQVLSNLLSNALKFTTE 846
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 267 QTLLIKNGITG-NDNFIIVQ----DQGPGIPEELQKSLFQPFQRGEYAKNinPEGCGLGLSVVKAIMCAHGGDVSYSLTP 341
Cdd:PRK09959 847 GAVKITTSLGHiDDNHAVIKmtimDSGSGLSQEEQQQLFKRYSQTSAGRQ--QTGSGLGLMICKELIKNMQGDLSLESHP 924
|
250
....*....|..
gi 490288705 342 ENGSLFKLSWPV 353
Cdd:PRK09959 925 GIGTTFTITIPV 936
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
142-353 |
1.07e-11 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 65.91 E-value: 1.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 142 AAIAHELRTPVTILRGRLQgLVDGVFEPEPSLFRNLLKQTEGLTNLIEDLRVVSSSGGAGYSlmlsEVDLKATISNALDT 221
Cdd:COG5805 292 AGIAHEIRNPLTSIKGFLQ-LLQPGIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNKE----KENINELIQDVVTL 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 222 FWPDFDKKHFKIVTEINQ--QYCVCDPLRIIQcltvLFDNalkystsqtlLIKNGI-------------TGNDNFII--V 284
Cdd:COG5805 367 LETEAILHNIQIRLELLDedPFIYCDENQIKQ----VFIN----------LIKNAIeampnggtitihtEEEDNSVIirV 432
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490288705 285 QDQGPGIPEELQKSLFQPFQrgeyakNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:COG5805 433 IDEGIGIPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
62-351 |
1.85e-11 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 65.06 E-value: 1.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 62 LMASITSLVVALFFTVKLSARIFNPLNDVAYSLKQisqgnlsaRAFNSSSKLG------EMNRLVNDFNEMAEKLQTLDA 135
Cdd:PRK10337 164 LIPWLVALPIMLIILMVLLGRELAPLKKLALALRM--------RDPDSETPLNatgvpsEVRPLVEALNQLFARTHAMMV 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 136 QRNLWNAAIAHELRTPVTILRgrLQGLVDGVFEPEPSLFRNLLKQ-TEGL---TNLIEDL----RVVSSSGGAGyslmLS 207
Cdd:PRK10337 236 RERRFTSDAAHELRSPLAALK--VQTEVAQLSDDDPQARKKALLQlHAGIdraTRLVDQLltlsRLDSLDNLQD----VA 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 208 EVDLKATISNALDTFWPDFDKKHFKIVTEINQQycvcDPLRIIQCLTV------LFDNALKYSTSQTLLiknGITGNDNF 281
Cdd:PRK10337 310 EIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAH----PVIRTGQPLLLsllvrnLLDNAIRYSPQGSVV---DVTLNARN 382
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490288705 282 IIVQDQGPGI-PEELQKsLFQPFQR--GEYAKninpeGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSW 351
Cdd:PRK10337 383 FTVRDNGPGVtPEALAR-IGERFYRppGQEAT-----GSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVSW 449
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-352 |
2.85e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 59.65 E-value: 2.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 249 IIQCLTVLFDNALKYSTSQ---TLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQR----GEYakninpEGCGLGL 321
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrppRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRlhsrEEY------EGTGVGL 74
|
90 100 110
....*....|....*....|....*....|.
gi 490288705 322 SVVKAIMCAHGGDVSYSLTPENGSLFKLSWP 352
Cdd:cd16921 75 AIVRKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-348 |
3.64e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 60.34 E-value: 3.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 256 LFDNALKYSTSQtLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQpfqRGEYAKNINPeGCGLGLSVVKAIMCAHGGDV 335
Cdd:cd16954 45 LLDNACKWCLEF-VEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQ---RGQRLDEQRP-GQGLGLAIAKEIVEQYGGEL 119
|
90
....*....|...
gi 490288705 336 SYSLTPENGSLFK 348
Cdd:cd16954 120 SLSDSPLGGARFE 132
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
65-333 |
5.49e-11 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 63.06 E-value: 5.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 65 SITSLV---VALFFTVKLSARIFNPLNDVAYSLKQISQGNLSARAFNSSSK-----LGEMNRLVNDFNEmaeklqTLDAQ 136
Cdd:PRK10755 64 LVPSLVmvsLTLLICFQAVRWITRPLAELQKELEARTADNLTPIAIHSSTLeieavTSALNQLVSRLTS------TLDQE 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 137 RnLWNAAIAHELRTPVTILRGRL-----QGLVDGvfepEPslfrnLLKQTEGLTNLIEDLRVVSSSGGAGYSLMLSEVDL 211
Cdd:PRK10755 138 R-LFTADVAHELRTPLAGIRLHLellekQHHIDV----AP-----LIARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 212 KATI----SNALDT---------FWPDfDKKHFKIVTeinqqycvcDP--LRIIqcLTVLFDNALKYSTSQ-TLLIKNGI 275
Cdd:PRK10755 208 LEDVilpsQDELSEmleqrqqtlLLPE-SAADITVQG---------DAtlLRLL--LRNLVENAHRYSPEGsTITIKLSQ 275
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 276 TGNDNFIIVQDQGPGIPEELQKSLFQPFQRGE--YAkninpeGCGLGLSVVKAIMCAHGG 333
Cdd:PRK10755 276 EDGGAVLAVEDEGPGIDESKCGELSKAFVRMDsrYG------GIGLGLSIVSRITQLHHG 329
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
125-353 |
5.73e-11 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 63.27 E-value: 5.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 125 EMAEKlQTLDAQRNLwNAAIAHELRTPVTILRGRLQGLvdGVFEPEPSLFRNL----LKQTEGLTNLIEDL-RVVSSSgg 199
Cdd:PRK10364 227 EMKRK-EKLVALGHL-AAGVAHEIRNPLSSIKGLAKYF--AERAPAGGEAHQLaqvmAKEADRLNRVVSELlELVKPT-- 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 200 agySLMLSEVDLKATISNALDTFWPDFDKKHFKI-------VTEINqqycvCDPLRIIQCLTVLFDNALKYSTSQ-TLLI 271
Cdd:PRK10364 301 ---HLALQAVDLNDLINHSLQLVSQDANSREIQLrftandtLPEIQ-----ADPDRLTQVLLNLYLNAIQAIGQHgVISV 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 272 KNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRgeyAKNinpEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSW 351
Cdd:PRK10364 373 TASESGAGVKISVTDSGKGIAADQLEAIFTPYFT---TKA---EGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWL 446
|
..
gi 490288705 352 PV 353
Cdd:PRK10364 447 PV 448
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
284-352 |
1.32e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 57.80 E-value: 1.32e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490288705 284 VQDQGPGIPEELQKSLFQPFQRGEyakninPEGCGLGLSVVKAIMCAHGGDVSYSLTPENgSLFKLSWP 352
Cdd:cd16918 48 VIDNGPGIPPDLQDTIFYPMVSGR------ENGTGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-352 |
2.20e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 57.01 E-value: 2.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 256 LFDNALKYSTSQTLL-IKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNinPEGCGLGLSVVKAIMCAHGGD 334
Cdd:cd16923 8 LLSNAIKYSPENTRIyITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAIIELHGGS 85
|
90
....*....|....*...
gi 490288705 335 VSYSLTpENGSLFKLSWP 352
Cdd:cd16923 86 ASAEYD-DNHDLFKVRLP 102
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-343 |
3.74e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 56.81 E-value: 3.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 249 IIQCLTVLFDNALKYSTSQT--LLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSVVKA 326
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTgrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90
....*....|....*..
gi 490288705 327 IMCAHGGdvsySLTPEN 343
Cdd:cd16953 81 IIEAHGG----ISVAEN 93
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
4-208 |
5.49e-10 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 60.90 E-value: 5.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 4 ETILSRQILTYMLLLTFVIIAIAILGSYLFYSFLIYYLPGGMNEGSEDAMTFLDWMWILMASITSLVVALFFTVKLSARI 83
Cdd:COG2770 157 LLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRI 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 84 FNPLNDVAYSLKQISQGNLSARaFNSSSKlGEMNRLVNDFNEMAEKLQTLDAQRNLWNAAIAHELRTPVTILRGRLQGLV 163
Cdd:COG2770 237 TRPLRRLAEAARRIAAGDLDVR-IPVSRK-DEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALL 314
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 490288705 164 DGVFEPEPSLFRNLLKQTEGLTNLIEDLRVVSSSGGAGYSLMLSE 208
Cdd:COG2770 315 LLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAAL 359
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
59-334 |
7.75e-10 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 60.09 E-value: 7.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 59 MWILMASITSLVVALFFTVKL-SARIFNPLNDVAYSLKQISQGNLSAR-AFNSSSKLGEMNRLVNDF-NEMAEKLQTLD- 134
Cdd:COG4192 326 ILLLAIALLSLLLAVLINYFYvRRRLVKRLNALSDAMAAIAAGDLDVPiPVDGNDEIGRIARLLRVFrDQAIEKTQELEt 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 135 --------------AQRNLWNAA-----------IAHELRTPVTILRGRLQGLVDGVFEPEPSLFRNLLKQTEGLT---- 185
Cdd:COG4192 406 eieerkrieknlrqTQDELIQAAkmavvgqtmtsLAHELNQPLNAMSMYLFSAKKALEQENYAQLPTSLDKIEGLIermd 485
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 186 NLIEDLRVVSSSGGAGyslmLSEVDLKATISNALDTFwpDFDKKHFKIVTEINQQYCVC-DPLRIIQCLTVLFDNALKYS 264
Cdd:COG4192 486 KIIKSLRQFSRKSDTP----LQPVDLRQVIEQAWELV--ESRAKPQQITLHIPDDLMVQgDQVLLEQVLVNLLVNALDAV 559
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490288705 265 TSQTLL-IKNGITGNDNFIIVQDQGPGIPeeLQKSLFQPFQRgeyAKNInpeGCGLGLSVVKAIMCAHGGD 334
Cdd:COG4192 560 ATQPQIsVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFTT---TKEV---GLGLGLSICRSIMQQFGGD 622
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
144-353 |
8.28e-10 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 60.43 E-value: 8.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 144 IAHELRTPVTILRGRLQGLVDGVFEPEP-SLFRNLLKQTEGLTNLIEDLRVVSSSGGAGYSLMLSEVDLKATISNALDTF 222
Cdd:PRK15347 405 ISHEIRTPLNGVLGALELLQNTPLTAEQmDLADTARQCTLSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTI 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 223 WPDFDKKHFKIVTEINQ---QYCVCDPLRIIQCLTVLFDNALKYSTSQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSL 299
Cdd:PRK15347 485 QGPAQSKSLTLRTFVGAhvpLYLHLDSLRLRQILVNLLGNAVKFTETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQI 564
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 490288705 300 FQPFqrgeYAKNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:PRK15347 565 FTPF----YQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-349 |
9.63e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 55.16 E-value: 9.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 249 IIQCLTVLFDNALKYSTSQT---LLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFqrgeYAKNINPEGCGLGLSVVK 325
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVEnprIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPF----FTTKPVGKGTGLGLSISY 76
|
90 100
....*....|....*....|....
gi 490288705 326 AIMCAHGGDVSYSLTPENGSLFKL 349
Cdd:cd16976 77 GIVEEHGGRLSVANEEGAGARFTF 100
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
245-352 |
7.92e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 52.92 E-value: 7.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 245 DPLRIIQCLTVLFDNALKYSTSQTLLIKNG-ITGNDNF-----IIVQDQGPGIPEELQKSLFQPFQrgeyakNINPEGCG 318
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVrIRVEADQdgrivLIVCDNGKGFPREMRHRATEPYV------TTRPKGTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 490288705 319 LGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWP 352
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
256-350 |
9.35e-09 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 56.40 E-value: 9.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 256 LFDNALKYSTSQ-------TLLIKngITGNDNFIIVQDQGPGIPEELQKSLfqpFQRGEYAKniNPEGCGLGLSVVKAIM 328
Cdd:COG3290 289 LLDNAIEAVEKLpeeerrvELSIR--DDGDELVIEVEDSGPGIPEELLEKI---FERGFSTK--LGEGRGLGLALVKQIV 361
|
90 100
....*....|....*....|..
gi 490288705 329 CAHGGDVSYSLTPENGSLFKLS 350
Cdd:COG3290 362 EKYGGTIEVESEEGEGTVFTVR 383
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
134-195 |
1.46e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 50.67 E-value: 1.46e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490288705 134 DAQRNLWNAAIAHELRTPVTILRGRLQGLVDGVFEPEPS--LFRNLLKQTEGLTNLIEDLRVVS 195
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQreYLERIREEAERLLRLINDLLDLS 64
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
135-352 |
1.49e-08 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 55.79 E-value: 1.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 135 AQRNLWnAAIAHELRTPVTILRGRLQGLVDGVFE--PEPSLFRNLLKQTEGLTNLIEDLRVVSSSGGAGYSLMLSEVDLK 212
Cdd:PRK11006 203 ARRNFF-ANVSHELRTPLTVLQGYLEMMQDQPLEgaLREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVP 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 213 ATI------SNALDtfwpdfDKKHfKIVTEINQQYCVC---DPLRiiQCLTVLFDNALKYSTSQT-LLIKNGITGNDNFI 282
Cdd:PRK11006 282 MMLrvlereAQTLS------QGKH-TITFEVDNSLKVFgneDQLR--SAISNLVYNAVNHTPEGThITVRWQRVPQGAEF 352
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 283 IVQDQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWP 352
Cdd:PRK11006 353 SVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
61-149 |
2.00e-08 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 55.66 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 61 ILMASITSLVVALFFTVKLSARIFNPLNDVAYSLKQISQGNLSARAfnSSSKLGEMNRLVNDFNEMAEKLQTLDAQRNLW 140
Cdd:COG3850 120 ALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARV--PVSGRDELGTLARAFNRMADELQELYAELEEE 197
|
....*....
gi 490288705 141 NAAIAHELR 149
Cdd:COG3850 198 EELEAELEL 206
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
136-195 |
2.69e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 49.87 E-value: 2.69e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490288705 136 QRNLWNAAIAHELRTPVTILRGRLQGLVDGVFEPEPS-LFRNLLKQTEGLTNLIEDLRVVS 195
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQReYLETILREAERLLRLINDLLDLS 61
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-352 |
2.94e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 51.05 E-value: 2.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 256 LFDNALKYS-TSQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGD 334
Cdd:cd16952 8 LVSNAVKYTpPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDAR 87
|
90
....*....|....*...
gi 490288705 335 VSYSLTPENGSLFKLSWP 352
Cdd:cd16952 88 LLIASELGKGSRFTCLFP 105
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
136-196 |
3.91e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 49.52 E-value: 3.91e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490288705 136 QRNLWNAAIAHELRTPVTILRGRLQGLVDGVFEPEPS-LFRNLLKQTEGLTNLIEDLRVVSS 196
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQReYLETILRSAERLLRLINDLLDLSR 62
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-347 |
9.74e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 50.20 E-value: 9.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 256 LFDNALKYSTSQTLLiknGITGNDN----FIIVQDQGPGIPEELQKSLFQPFQRGEYAKNINPEGCGLGLSVVKAIMCAH 331
Cdd:cd16947 28 LISNAIKYGSDGKFL---GMTLREDekhvYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTITKRLAESM 104
|
90
....*....|....*.
gi 490288705 332 GGDVSYSLTPENGSLF 347
Cdd:cd16947 105 GGSIYVNSKPYEKTVF 120
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
245-352 |
1.26e-07 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 53.44 E-value: 1.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 245 DPLRIIQCLTVLFDNALKYSTSQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPF-QRGEyAKNINPEGCGLGLSV 323
Cdd:PRK10841 559 DPMRLQQVISNLLSNAIKFTDTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFfQVGT-GVQRNFQGTGLGLAI 637
|
90 100
....*....|....*....|....*....
gi 490288705 324 VKAIMCAHGGDVSYSLTPENGSLFKLSWP 352
Cdd:PRK10841 638 CEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
256-344 |
1.67e-07 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 52.71 E-value: 1.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 256 LFDNALKY-------STSQTllikngitGNDNFIIVQDQGPGIPEElQKSLFqpFQRGEYAKNINPeGCGLGLSVVKAIM 328
Cdd:PRK10815 386 VLDNACKYclefveiSARQT--------DEHLHIVVEDDGPGIPES-KRELI--FDRGQRADTLRP-GQGLGLSVAREIT 453
|
90
....*....|....*.
gi 490288705 329 CAHGGDVSYSLTPENG 344
Cdd:PRK10815 454 EQYEGKISAGDSPLGG 469
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
245-347 |
2.37e-07 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 52.54 E-value: 2.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 245 DPLRIIQCLTVLFDNALKYSTSQTLLIKNGITGNDN-----FIIVQDQGPGIPEELQKSLFQPF---------QRGeyak 310
Cdd:PRK11107 405 DPLRLQQIITNLVGNAIKFTESGNIDILVELRALSNtkvqlEVQIRDTGIGISERQQSQLFQAFrqadasisrRHG---- 480
|
90 100 110
....*....|....*....|....*....|....*..
gi 490288705 311 ninpeGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLF 347
Cdd:PRK11107 481 -----GTGLGLVITQKLVNEMGGDISFHSQPNRGSTF 512
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
61-136 |
5.41e-07 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 51.17 E-value: 5.41e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490288705 61 ILMASITSLVVALFFTVKLSARIFNPLNDVAYSLKQISQGNLSARAfNSSSKlGEMNRLVNDFNEMAEKLQTLDAQ 136
Cdd:COG0840 184 LAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRI-DVDSK-DEIGQLADAFNRMIENLRELVGQ 257
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
229-353 |
1.22e-06 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 50.32 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 229 KHFKIVTEINQ---QYCVCDPLRIIQCLTVLFDNALKYSTSQTLLIKNGITGNDNFII-VQDQGPGIPEELQKSLFQPFQ 304
Cdd:PRK11091 376 KGLRFDLEPLLplpHKVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDMLTFeVEDSGIGIPEDELDKIFAMYY 455
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 490288705 305 RGEYAKNINPE-GCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:PRK11091 456 QVKDSHGGKPAtGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
111-352 |
3.00e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 48.54 E-value: 3.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 111 SKLGEMNRLVNDFNEMAEKLQTLDAQRNLwnaaiAHELRTPVTILRGRLQGLVDGVfePEPSL-------------FRNL 177
Cdd:PRK11073 109 APMDNQRRLSQEQLQHAQQVAARDLVRGL-----AHEIKNPLGGLRGAAQLLSKAL--PDPALteytkviieqadrLRNL 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 178 -----------LKQTEGLTNLIEdlRVVSssggagyslmLSEVDLKATIsnaldTFWPDFDKKhfkiVTEINQqycvcDP 246
Cdd:PRK11073 182 vdrllgpqrpgTHVTESIHKVAE--RVVQ----------LVSLELPDNV-----RLIRDYDPS----LPELAH-----DP 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 247 LRIIQCLTVLFDNALKYSTSQ--TLLIKNGITGNDNF----------IIVQDQGPGIPEELQKSLFQPFQRGEYAkninp 314
Cdd:PRK11073 236 DQIEQVLLNIVRNALQALGPEggTITLRTRTAFQLTLhgeryrlaarIDIEDNGPGIPPHLQDTLFYPMVSGREG----- 310
|
250 260 270
....*....|....*....|....*....|....*...
gi 490288705 315 eGCGLGLSVVKAIMCAHGGDVSYSltpengslfklSWP 352
Cdd:PRK11073 311 -GTGLGLSIARNLIDQHSGKIEFT-----------SWP 336
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
245-344 |
4.19e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 45.14 E-value: 4.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 245 DPLRIIQCLTVLFDNALKYST-SQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNiNPEGCGLGLSV 323
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPeGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHS-GQKSTGLGLAF 79
|
90 100
....*....|....*....|.
gi 490288705 324 VKAIMCAHGGDVSYSLTPENG 344
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPDGV 100
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
6-133 |
6.46e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 47.71 E-value: 6.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 6 ILSRQILTYMLLLTFVIIAIAILGSYLFYSFLIYYLPggMNEGSEDAMTFLdwMWILMASITSLVVALFFTVKLSARIFN 85
Cdd:COG2972 108 LLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIP--KSELFRGLFSLR--RLILLIILLLLLLALLLSYLLSRSITR 183
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 490288705 86 PLNDVAYSLKQISQGNLSARAFNSSSKLGEMNRLvndFNEMAEKLQTL 133
Cdd:COG2972 184 PIKRLKKAMKKVEKGDLVRLEVSGNDEIGILARS---FNEMVERIKEL 228
|
|
| HAMP |
pfam00672 |
HAMP domain; |
79-132 |
1.17e-05 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 42.23 E-value: 1.17e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 490288705 79 LSARIFNPLNDVAYSLKQISQGNLSARAFNSSSklGEMNRLVNDFNEMAEKLQT 132
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGR--DEIGELARAFNQMAERLRE 53
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
86-130 |
1.93e-05 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 41.28 E-value: 1.93e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 490288705 86 PLNDVAYSLKQISQGNLSARAFNSSSklGEMNRLVNDFNEMAEKL 130
Cdd:cd06225 3 PLRRLTEAARRIAEGDLDVRVPVRSK--DEIGELARAFNQMAERL 45
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-352 |
2.58e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 42.66 E-value: 2.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 256 LFDNALKYSTSQ-----TLLIKNGITGNDNFIIVQDQGPGIPEELQKSLfqpFQRGEYAKniNPEGCGLGLSVVKAIMCA 330
Cdd:cd16915 8 LIDNALDALAATgapnkQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKV---FERGVSTK--GQGERGIGLALVRQSVER 82
|
90 100
....*....|....*....|..
gi 490288705 331 HGGDVSYSLTPENGSLFKLSWP 352
Cdd:cd16915 83 LGGSITVESEPGGGTTFSIRIP 104
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
82-135 |
3.26e-05 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 41.08 E-value: 3.26e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 490288705 82 RIFNPLNDVAYSLKQISQGNLSARAFNSSSklGEMNRLVNDFNEMAEKLQTLDA 135
Cdd:smart00304 2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGR--DEIGELARAFNEMADRLEETIA 53
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
284-353 |
8.20e-05 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 44.67 E-value: 8.20e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490288705 284 VQDQGPGIPEELQKSLFQPF--QRgeyakninPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWPV 353
Cdd:PRK13837 612 VSDTGAGIDEAVLPHIFEPFftTR--------AGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPP 675
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
277-352 |
1.98e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 43.28 E-value: 1.98e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490288705 277 GNDNFIIVQDQGPGIPEELQKSLfqpFQRGEYAKNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWP 352
Cdd:PRK15053 466 GDDVVIEVADQGCGVPESLRDKI---FEQGVSTRADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
259-352 |
5.77e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 38.81 E-value: 5.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 259 NALKYST-SQTLLIKNGITGNDNFIIVQDQGPGIPEELQKSLFQPFQRGEYAKNINpEGCGLGLSVVKAIMCAHGGDVSY 337
Cdd:cd16948 16 NALKYSKqGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQ-ESTGMGLYLVKKLCDKLGHKIDV 94
|
90
....*....|....*
gi 490288705 338 SLTPENGSLFKLSWP 352
Cdd:cd16948 95 ESEVGEGTTFTITFP 109
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
245-349 |
3.26e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 36.67 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 245 DPLRIIQCLTVLFDNALKYSTSQ---TLLIKNgitgNDNFI--IVQDQGPGIPEELQKSLFQPFQRGEYAKNINPEgCGL 319
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGgtvSISIYD----EEEYLyfEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGH-YGM 75
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90 100 110
....*....|....*....|....*....|
gi 490288705 320 GLSVVKAIMCAHGGDVSYSLTPENGSLFKL 349
Cdd:cd16975 76 GLYIAKNLVEKHGGSLIIENSQKGGAEVTV 105
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| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
245-337 |
4.36e-03 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 36.48 E-value: 4.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490288705 245 DPLRIIQCLTVLFDNALKYSTSQTLLI-------KNGITGNDNFIIVQ----DQGPGIPEELQKSLFQPfqrgeyAKNIN 313
Cdd:cd16932 3 DQIRLQQVLADFLLNAVRFTPSPGGWVeikvsptKKQIGDGVHVIHLEfritHPGQGLPEELVQEMFEE------NQWTT 76
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90 100
....*....|....*....|....
gi 490288705 314 PEgcGLGLSVVKAIMCAHGGDVSY 337
Cdd:cd16932 77 QE--GLGLSISRKLVKLMNGDVRY 98
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| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
275-352 |
6.09e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 36.20 E-value: 6.09e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490288705 275 ITGNDNFIIVQDQGPGIPEELQKSLFQPFqrgeYAKNINPEGCGLGLSVVKAIMCAHGGDVSYSLTPENGSLFKLSWP 352
Cdd:cd16919 43 IPGNYVCLEVSDTGSGMPAEVLRRAFEPF----FTTKEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
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