NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|490293989|ref|WP_004189553|]
View 

MULTISPECIES: heme ABC transporter permease [Klebsiella]

Protein Classification

heme ABC transporter permease( domain architecture ID 10018730)

heme ABC transporter permease such as Escherichia coli heme exporter protein C (CcmC), which is required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

Gene Ontology:  GO:0020037|GO:0015232|GO:0017004|GO:0016020
PubMed:  10998170

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ccmC TIGR01191
heme exporter protein CcmC; This model describes the cyt c biogenesis protein encoded by ccmC ...
 45-225 2.00e-86

heme exporter protein CcmC; This model describes the cyt c biogenesis protein encoded by ccmC in bacteria. It must be noted an arabidopsis, a tritcum and a piscum plant proteins were recognizable in the clade. Quite likely they are of organellar origin. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes, ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in the heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other]


:

Pssm-ID: 273492  Cd Length: 184  Bit Score: 254.60  E-value: 2.00e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989   45 PADYQQGESYRIMYLHVPTAMWSMGLYLAMAVAAFVGVVWQIKMADLAIAALAPVGAVCTLVALVSGAAWGKPMWGTWWI 124
Cdd:TIGR01191   1 PVDYQQGASVRIMYVHVPAAWMAIGVYIMMAIASFIFLVWKHPLSDLAAKAAAPIGAVFTLIALVTGSLWGKPMWGTWWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989  125 WDARLTSELVLLFLYAGVIALWHAFDDRRLAGRAAGILVLVGVVNLPIIHYSVYWWNTLHQGSTNL---QQTIDPSMRLP 201
Cdd:TIGR01191  81 WDARLTSVLILFLLYLGYLALWEAIDNRDSAAKAAGILCLVGVVNIPIIKFSVEWWNTLHQPASITrfgSPSIHVSMLIP 160

                         170       180
                  ....*....|....*....|....
gi 490293989  202 LRICIFAFLTLSVTLTLMRLRNLI 225
Cdd:TIGR01191 161 LLLMFAGFLLLFLALLLLRTRLEI 184
 
Name Accession Description Interval E-value
ccmC TIGR01191
heme exporter protein CcmC; This model describes the cyt c biogenesis protein encoded by ccmC ...
 45-225 2.00e-86

heme exporter protein CcmC; This model describes the cyt c biogenesis protein encoded by ccmC in bacteria. It must be noted an arabidopsis, a tritcum and a piscum plant proteins were recognizable in the clade. Quite likely they are of organellar origin. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes, ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in the heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other]


Pssm-ID: 273492  Cd Length: 184  Bit Score: 254.60  E-value: 2.00e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989   45 PADYQQGESYRIMYLHVPTAMWSMGLYLAMAVAAFVGVVWQIKMADLAIAALAPVGAVCTLVALVSGAAWGKPMWGTWWI 124
Cdd:TIGR01191   1 PVDYQQGASVRIMYVHVPAAWMAIGVYIMMAIASFIFLVWKHPLSDLAAKAAAPIGAVFTLIALVTGSLWGKPMWGTWWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989  125 WDARLTSELVLLFLYAGVIALWHAFDDRRLAGRAAGILVLVGVVNLPIIHYSVYWWNTLHQGSTNL---QQTIDPSMRLP 201
Cdd:TIGR01191  81 WDARLTSVLILFLLYLGYLALWEAIDNRDSAAKAAGILCLVGVVNIPIIKFSVEWWNTLHQPASITrfgSPSIHVSMLIP 160

                         170       180
                  ....*....|....*....|....
gi 490293989  202 LRICIFAFLTLSVTLTLMRLRNLI 225
Cdd:TIGR01191 161 LLLMFAGFLLLFLALLLLRTRLEI 184
CcmC COG0755
ABC-type transport system involved in cytochrome c biogenesis, permease component ...
 34-184 1.66e-41

ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440518 [Multi-domain]  Cd Length: 213  Bit Score: 140.80  E-value: 1.66e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989  34 VIGLGWGFGFAPADYQQG---ESYRIMYLHVPTAMWSMGLYLAMAVAAFVGVVWQ----------IKMADLAIAALAPVG 100
Cdd:COG0755   47 LALLLLAFLFADPEITPLvpaLDSRWLYIHVPAAWLSYGAFALAAVLSLLYLVWRrflkklarpsLKLLDRLAYAAAPIG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989 101 AVCTLVALVSGAAWGKPMWGTWWIWDARLTSELVLLFLYAGVIALWHAfddRRLAGRAAGILVLVGVVNLPIIHYSVYWW 180
Cdd:COG0755  127 FPFLTLGLITGAIWAKPAWGRYWGWDPKETWALILWLLYAGYLHLRLA---IGWRGRAAAVLAIVGFVNVPIIYFGVNWW 203


                 ....*
gi 490293989 181 NT-LH 184
Cdd:COG0755  204 LSgLH 208
Cytochrom_C_asm pfam01578
Cytochrome C assembly protein; This family consists of various proteins involved in cytochrome ...
 34-184 4.79e-31

Cytochrome C assembly protein; This family consists of various proteins involved in cytochrome c assembly from mitochondria and bacteria; CycK from Rhizobium, CcmC from E. coli and Paracoccus denitrificans.and orf240 from wheat mitochondria. The members of this family are probably integral membrane proteins with six predicted transmembrane helices. It has been proposed that members of this family comprise a membrane component of an ABC (ATP binding cassette) transporter complex. It is also proposed that this transporter is necessary for transport of some component needed for cytochrome c assembly. One member CycK contains a putative heme-binding motif, orf240 also contains a putative heme-binding motif and is a proposed ABC transporter with c-type heme as its proposed substrate. However it seems unlikely that all members of this family transport heme nor c-type apocytochromes because CcmC in the putative CcmABC transporter transports neither. CcmF forms a working module with CcmH and CcmI, CcmFHI, and itself is unlikely to bind haem directly.


Pssm-ID: 307628 [Multi-domain]  Cd Length: 211  Bit Score: 113.99  E-value: 4.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989   34 VIGLGWGFGFA--------PADYQQGESYRIMYLHVPTAMWSMGLYLAMAVAAFVGVV--------------WQIKMADL 91
Cdd:pfam01578  41 SSMIILGFLLFllpatpqpGADLNPGLQSPILMLHVPLALLSYATLIIAALLSIALLLidrakkklknsnnlPPLKTLDR 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989   92 AIAALAPVGAVCTLVALVSGAAWGKPMWGTWWIWDARLTSELVLLFLYAGVIALWHAFddRRLAGRAAGILVLVGVVNLP 171
Cdd:pfam01578 121 LSYRIILIGFVFLTLGLITGSLWANEMWGTYWVWDPKETASLILWLVYAALLHSRIAT--KGWRGKKAAILAILGFVLLL 198

                         170
                  ....*....|...
gi 490293989  172 IIHYSVYWWNTLH 184
Cdd:pfam01578 199 IAYFGVRSWEGLH 211
 
Name Accession Description Interval E-value
ccmC TIGR01191
heme exporter protein CcmC; This model describes the cyt c biogenesis protein encoded by ccmC ...
 45-225 2.00e-86

heme exporter protein CcmC; This model describes the cyt c biogenesis protein encoded by ccmC in bacteria. It must be noted an arabidopsis, a tritcum and a piscum plant proteins were recognizable in the clade. Quite likely they are of organellar origin. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes, ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in the heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other]


Pssm-ID: 273492  Cd Length: 184  Bit Score: 254.60  E-value: 2.00e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989   45 PADYQQGESYRIMYLHVPTAMWSMGLYLAMAVAAFVGVVWQIKMADLAIAALAPVGAVCTLVALVSGAAWGKPMWGTWWI 124
Cdd:TIGR01191   1 PVDYQQGASVRIMYVHVPAAWMAIGVYIMMAIASFIFLVWKHPLSDLAAKAAAPIGAVFTLIALVTGSLWGKPMWGTWWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989  125 WDARLTSELVLLFLYAGVIALWHAFDDRRLAGRAAGILVLVGVVNLPIIHYSVYWWNTLHQGSTNL---QQTIDPSMRLP 201
Cdd:TIGR01191  81 WDARLTSVLILFLLYLGYLALWEAIDNRDSAAKAAGILCLVGVVNIPIIKFSVEWWNTLHQPASITrfgSPSIHVSMLIP 160

                         170       180
                  ....*....|....*....|....
gi 490293989  202 LRICIFAFLTLSVTLTLMRLRNLI 225
Cdd:TIGR01191 161 LLLMFAGFLLLFLALLLLRTRLEI 184
CcmC COG0755
ABC-type transport system involved in cytochrome c biogenesis, permease component ...
 34-184 1.66e-41

ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440518 [Multi-domain]  Cd Length: 213  Bit Score: 140.80  E-value: 1.66e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989  34 VIGLGWGFGFAPADYQQG---ESYRIMYLHVPTAMWSMGLYLAMAVAAFVGVVWQ----------IKMADLAIAALAPVG 100
Cdd:COG0755   47 LALLLLAFLFADPEITPLvpaLDSRWLYIHVPAAWLSYGAFALAAVLSLLYLVWRrflkklarpsLKLLDRLAYAAAPIG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989 101 AVCTLVALVSGAAWGKPMWGTWWIWDARLTSELVLLFLYAGVIALWHAfddRRLAGRAAGILVLVGVVNLPIIHYSVYWW 180
Cdd:COG0755  127 FPFLTLGLITGAIWAKPAWGRYWGWDPKETWALILWLLYAGYLHLRLA---IGWRGRAAAVLAIVGFVNVPIIYFGVNWW 203


                 ....*
gi 490293989 181 NT-LH 184
Cdd:COG0755  204 LSgLH 208
Cytochrom_C_asm pfam01578
Cytochrome C assembly protein; This family consists of various proteins involved in cytochrome ...
 34-184 4.79e-31

Cytochrome C assembly protein; This family consists of various proteins involved in cytochrome c assembly from mitochondria and bacteria; CycK from Rhizobium, CcmC from E. coli and Paracoccus denitrificans.and orf240 from wheat mitochondria. The members of this family are probably integral membrane proteins with six predicted transmembrane helices. It has been proposed that members of this family comprise a membrane component of an ABC (ATP binding cassette) transporter complex. It is also proposed that this transporter is necessary for transport of some component needed for cytochrome c assembly. One member CycK contains a putative heme-binding motif, orf240 also contains a putative heme-binding motif and is a proposed ABC transporter with c-type heme as its proposed substrate. However it seems unlikely that all members of this family transport heme nor c-type apocytochromes because CcmC in the putative CcmABC transporter transports neither. CcmF forms a working module with CcmH and CcmI, CcmFHI, and itself is unlikely to bind haem directly.


Pssm-ID: 307628 [Multi-domain]  Cd Length: 211  Bit Score: 113.99  E-value: 4.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989   34 VIGLGWGFGFA--------PADYQQGESYRIMYLHVPTAMWSMGLYLAMAVAAFVGVV--------------WQIKMADL 91
Cdd:pfam01578  41 SSMIILGFLLFllpatpqpGADLNPGLQSPILMLHVPLALLSYATLIIAALLSIALLLidrakkklknsnnlPPLKTLDR 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490293989   92 AIAALAPVGAVCTLVALVSGAAWGKPMWGTWWIWDARLTSELVLLFLYAGVIALWHAFddRRLAGRAAGILVLVGVVNLP 171
Cdd:pfam01578 121 LSYRIILIGFVFLTLGLITGSLWANEMWGTYWVWDPKETASLILWLVYAALLHSRIAT--KGWRGKKAAILAILGFVLLL 198

                         170
                  ....*....|...
gi 490293989  172 IIHYSVYWWNTLH 184
Cdd:pfam01578 199 IAYFGVRSWEGLH 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH