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Conserved domains on  [gi|490298611|ref|WP_004194048|]
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MULTISPECIES: Na+/H+ antiporter NhaA [Bacteria]

Protein Classification

Na+/H+ antiporter NhaA( domain architecture ID 10013271)

Na+/H+ antiporter NhaA extrudes sodium in exchange for external protons

CATH:  1.20.1530.10
Gene Ontology:  GO:0006885|GO:0015297|GO:0015081
TCDB:  2.A.36

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
nhaA PRK09560
pH-dependent sodium/proton antiporter; Reviewed
13-390 0e+00

pH-dependent sodium/proton antiporter; Reviewed


:

Pssm-ID: 236568  Cd Length: 389  Bit Score: 532.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  13 IKPVSNFFSSPVAGGIVLIIASAAAIIVANSPLREGYETLLKYKTA--------GLSVEHWINDALMAVFFMMVGLEIKR 84
Cdd:PRK09560   2 LSVIRRFLKSEAAGGILLMAAAALAMIVANSPLSEGYFSFLHTPVAiqigafsiGKSLLHWINDGLMAVFFLLVGLEIKR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  85 ELVTGQLATWSQRALPGFAALGGLAVPALIYVGFNAGHDETLSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALAI 164
Cdd:PRK09560  82 ELLEGQLSSWQQRILPAIAAVGGMVVPALIYAAFNYNNPETLRGWAIPAATDIAFALGVLALLGKRVPVSLKVFLLALAI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 165 LDDMGAVAIIALFYTSNISLLMLGGAAAMVALLFSLNRAGVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLRT 244
Cdd:PRK09560 162 IDDLGAIVIIALFYTSDLSLPALALAAIAIAVLFLLNRLGVTKLTPYLIVGAILWFAVLKSGVHATLAGVVLAFCIPLKG 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 245 RNAADEVPLDRLEHAINPWVTFMILPLFGFANAGVALSGMTMNDLLSPVPVGVALGLFLGKQAGIFGLSLLAVSLGLAKR 324
Cdd:PRK09560 242 KKGDEESPLHHLEHALHPWVAFAILPLFAFANAGVSLAGISLSSLTSPVPLGIALGLFLGKQVGVFGFSWLAVKLGLAKL 321
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490298611 325 PEKSTWLQVYGVSVLCGIGFTMSLFIGNLAFTGSPLLVDEVKVGVLAGSILAALAGILILRFAPSK 390
Cdd:PRK09560 322 PEGANWKQIYGVSVLCGIGFTMSLFIGSLAFGASEELLTEARLGILLGSLLSAILGYLLLRLTLRK 387
 
Name Accession Description Interval E-value
nhaA PRK09560
pH-dependent sodium/proton antiporter; Reviewed
13-390 0e+00

pH-dependent sodium/proton antiporter; Reviewed


Pssm-ID: 236568  Cd Length: 389  Bit Score: 532.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  13 IKPVSNFFSSPVAGGIVLIIASAAAIIVANSPLREGYETLLKYKTA--------GLSVEHWINDALMAVFFMMVGLEIKR 84
Cdd:PRK09560   2 LSVIRRFLKSEAAGGILLMAAAALAMIVANSPLSEGYFSFLHTPVAiqigafsiGKSLLHWINDGLMAVFFLLVGLEIKR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  85 ELVTGQLATWSQRALPGFAALGGLAVPALIYVGFNAGHDETLSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALAI 164
Cdd:PRK09560  82 ELLEGQLSSWQQRILPAIAAVGGMVVPALIYAAFNYNNPETLRGWAIPAATDIAFALGVLALLGKRVPVSLKVFLLALAI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 165 LDDMGAVAIIALFYTSNISLLMLGGAAAMVALLFSLNRAGVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLRT 244
Cdd:PRK09560 162 IDDLGAIVIIALFYTSDLSLPALALAAIAIAVLFLLNRLGVTKLTPYLIVGAILWFAVLKSGVHATLAGVVLAFCIPLKG 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 245 RNAADEVPLDRLEHAINPWVTFMILPLFGFANAGVALSGMTMNDLLSPVPVGVALGLFLGKQAGIFGLSLLAVSLGLAKR 324
Cdd:PRK09560 242 KKGDEESPLHHLEHALHPWVAFAILPLFAFANAGVSLAGISLSSLTSPVPLGIALGLFLGKQVGVFGFSWLAVKLGLAKL 321
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490298611 325 PEKSTWLQVYGVSVLCGIGFTMSLFIGNLAFTGSPLLVDEVKVGVLAGSILAALAGILILRFAPSK 390
Cdd:PRK09560 322 PEGANWKQIYGVSVLCGIGFTMSLFIGSLAFGASEELLTEARLGILLGSLLSAILGYLLLRLTLRK 387
NhaA COG3004
Na+/H+ antiporter NhaA [Energy production and conversion, Inorganic ion transport and ...
16-391 1.72e-173

Na+/H+ antiporter NhaA [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442241  Cd Length: 387  Bit Score: 488.82  E-value: 1.72e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  16 VSNFFSSPVAGGIVLIIASAAAIIVANSPLREGYETLLKYKTA--------GLSVEHWINDALMAVFFMMVGLEIKRELV 87
Cdd:COG3004    1 LRRFLRSEAAGGILLLLAAVLALIWANSPLAESYEALLHTPLGlgigslhlDLSLLHWINDGLMAIFFFLVGLEIKRELL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  88 TGQLATWSQRALPGFAALGGLAVPALIYVGFNAGHDETLSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALAILDD 167
Cdd:COG3004   81 VGELSSPRKAALPIIAALGGMVVPALIYLAFNAGTPEAARGWAIPMATDIAFALGVLALLGSRVPASLRVFLLALAIVDD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 168 MGAVAIIALFYTSNISLLMLGGAAAMVALLFSLNRAGVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLRTRNA 247
Cdd:COG3004  161 LGAILVIALFYTSGLSLLALLLAAAALALLALLNRRGVRSLWPYLLLGVVLWYAVLKSGVHATLAGVLLALTIPARPRVG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 248 ADEV---PLDRLEHAINPWVTFMILPLFGFANAGVALSGMTMNDLLSPVPVGVALGLFLGKQAGIFGLSLLAVSLGLAKR 324
Cdd:COG3004  241 GEEEaesPLERLEHALHPWVAFLILPLFAFANAGVSLSGLSLAALTSPVTLGIALGLVLGKPLGIFGFSWLAVKLGLARL 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490298611 325 PEKSTWLQVYGVSVLCGIGFTMSLFIGNLAFTGSPLLvDEVKVGVLAGSILAALAGILILRFAPSKQ 391
Cdd:COG3004  321 PAGVSWRQLYGVGLLAGIGFTMSLFIAELAFPDPELL-DAAKLGILLGSLLAAVLGYLLLRLRLRRK 386
Na_H_antiport_1 pfam06965
Na+/H+ antiporter 1; This family contains a number of bacterial Na+/H+ antiporter 1 proteins. ...
18-383 1.10e-169

Na+/H+ antiporter 1; This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyze the exchange of H+ for Na+ in a manner that is highly dependent on the pH.


Pssm-ID: 429217  Cd Length: 378  Bit Score: 478.82  E-value: 1.10e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611   18 NFFSSPVAGGIVLIIASAAAIIVANSPLREGYETLLKYKTA--------GLSVEHWINDALMAVFFMMVGLEIKRELVTG 89
Cdd:pfam06965   2 RFLRSEAAGGILLLAAAVLALIWANSPLADSYEALWHTPLGvgfgglslSLSLHHWINDGLMAIFFFVVGLEIKRELLVG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611   90 QLATWSQRALPGFAALGGLAVPALIYVGFNAGHdETLSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALAILDDMG 169
Cdd:pfam06965  82 ELSSPRKAALPVIAALGGMVVPALIYLAFNAGG-PGARGWAIPMATDIAFALGVLALLGKRVPASLRVFLLALAIVDDLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  170 AVAIIALFYTSNISLLMLGGAAAMVALLFSLNRAGVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLRTR-NAA 248
Cdd:pfam06965 161 AILVIALFYTSGLSLLALLAAAAILAVLLLLNRLGVRRLWPYLLLGVVLWVAVLKSGVHATIAGVLLALLIPARPPaRES 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  249 DEV--PLDRLEHAINPWVTFMILPLFGFANAGVALSGMTMNDLL-SPVPVGVALGLFLGKQAGIFGLSLLAVSLGLAKRP 325
Cdd:pfam06965 241 REAisPLERLEHALHPWVAFLILPLFALANAGVSLSGSGLGALLtSPVTLGIALGLVLGKPLGIFGFSWLAVKLGLARLP 320
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 490298611  326 EKSTWLQVYGVSVLCGIGFTMSLFIGNLAFTGSPLLVDEVKVGVLAGSILAALAGILI 383
Cdd:pfam06965 321 EGVTWRQLLGVGLLAGIGFTMSLFIAELAFDDELELLDEAKLGILLGSLLAAVLGYLV 378
NhaA TIGR00773
Na+/H+ antiporter NhaA; These proteins are members of the NhaA Na+:H+ Antiporter (NhaA) Family ...
19-384 2.98e-130

Na+/H+ antiporter NhaA; These proteins are members of the NhaA Na+:H+ Antiporter (NhaA) Family (TC. 2.A.33). The Escherichia coli NhaA protein probably functions in the regulation of the internal pH when the external pH is alkaline. It also uses the H+ gradient to expel Na+ from the cell. Its activity is highly pH dependent. Only the E. coli protein is functionally and structurally well characterized. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273264  Cd Length: 373  Bit Score: 378.73  E-value: 2.98e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611   19 FFSSPVAGGIVLIIASAAAIIVANSPLREGYETLLK--------YKTAGLSVEHWINDALMAVFFMMVGLEIKRELVTGQ 90
Cdd:TIGR00773   1 FFKSESAGGILLVIAAALAMVMANSALSEWYHDFLHtpvqlqigSFVIGKSLLHWINDGLMAVFFLLIGLEVKRELLEGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611   91 LATWSQRALPGFAALGGLAVPALIYVGFNAGHDETLSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALAILDDMGA 170
Cdd:TIGR00773  81 LSSLRQAIFPVIAAIGGMIAPALIYLAFNANDPITREGWAIPAATDIAFALGVMALLGKRVPLALKIFLLALAIIDDLGA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  171 VAIIALFYTSNISLLMLGGAAAMVALLFSLNRAGVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLRTRNaaDE 250
Cdd:TIGR00773 161 IVIIALFYTNDLSMAALLVAAVAIAVLAVLNRCGVRRLGPYMLVGVILWFAVLKSGVHATLAGVIIGFFIPLKGKK--GE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  251 VPLDRLEHAINPWVTFMILPLFGFANAGVALSGMTMNDLLSPVPVGVALGLFLGKQAGIFGLSLLAVSLGLAKRPEKSTW 330
Cdd:TIGR00773 239 SPLKRLEHVLHPWVAYLILPLFAFANAGVSLQGVSLNGLTSMLPLGIILGLLIGKPLGIFLFSWIAVKLKLAKLPEGINF 318
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 490298611  331 LQVYGVSVLCGIGFTMSLFIGNLAFTG-SPLLVDEVKVGVLAGSILAALAGILIL 384
Cdd:TIGR00773 319 KQIFAVGVLCGIGFTMSIFIASLAFGSvDPELITWAKLGILLGSTTSAVLGYSWL 373
 
Name Accession Description Interval E-value
nhaA PRK09560
pH-dependent sodium/proton antiporter; Reviewed
13-390 0e+00

pH-dependent sodium/proton antiporter; Reviewed


Pssm-ID: 236568  Cd Length: 389  Bit Score: 532.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  13 IKPVSNFFSSPVAGGIVLIIASAAAIIVANSPLREGYETLLKYKTA--------GLSVEHWINDALMAVFFMMVGLEIKR 84
Cdd:PRK09560   2 LSVIRRFLKSEAAGGILLMAAAALAMIVANSPLSEGYFSFLHTPVAiqigafsiGKSLLHWINDGLMAVFFLLVGLEIKR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  85 ELVTGQLATWSQRALPGFAALGGLAVPALIYVGFNAGHDETLSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALAI 164
Cdd:PRK09560  82 ELLEGQLSSWQQRILPAIAAVGGMVVPALIYAAFNYNNPETLRGWAIPAATDIAFALGVLALLGKRVPVSLKVFLLALAI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 165 LDDMGAVAIIALFYTSNISLLMLGGAAAMVALLFSLNRAGVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLRT 244
Cdd:PRK09560 162 IDDLGAIVIIALFYTSDLSLPALALAAIAIAVLFLLNRLGVTKLTPYLIVGAILWFAVLKSGVHATLAGVVLAFCIPLKG 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 245 RNAADEVPLDRLEHAINPWVTFMILPLFGFANAGVALSGMTMNDLLSPVPVGVALGLFLGKQAGIFGLSLLAVSLGLAKR 324
Cdd:PRK09560 242 KKGDEESPLHHLEHALHPWVAFAILPLFAFANAGVSLAGISLSSLTSPVPLGIALGLFLGKQVGVFGFSWLAVKLGLAKL 321
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490298611 325 PEKSTWLQVYGVSVLCGIGFTMSLFIGNLAFTGSPLLVDEVKVGVLAGSILAALAGILILRFAPSK 390
Cdd:PRK09560 322 PEGANWKQIYGVSVLCGIGFTMSLFIGSLAFGASEELLTEARLGILLGSLLSAILGYLLLRLTLRK 387
NhaA COG3004
Na+/H+ antiporter NhaA [Energy production and conversion, Inorganic ion transport and ...
16-391 1.72e-173

Na+/H+ antiporter NhaA [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442241  Cd Length: 387  Bit Score: 488.82  E-value: 1.72e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  16 VSNFFSSPVAGGIVLIIASAAAIIVANSPLREGYETLLKYKTA--------GLSVEHWINDALMAVFFMMVGLEIKRELV 87
Cdd:COG3004    1 LRRFLRSEAAGGILLLLAAVLALIWANSPLAESYEALLHTPLGlgigslhlDLSLLHWINDGLMAIFFFLVGLEIKRELL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  88 TGQLATWSQRALPGFAALGGLAVPALIYVGFNAGHDETLSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALAILDD 167
Cdd:COG3004   81 VGELSSPRKAALPIIAALGGMVVPALIYLAFNAGTPEAARGWAIPMATDIAFALGVLALLGSRVPASLRVFLLALAIVDD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 168 MGAVAIIALFYTSNISLLMLGGAAAMVALLFSLNRAGVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLRTRNA 247
Cdd:COG3004  161 LGAILVIALFYTSGLSLLALLLAAAALALLALLNRRGVRSLWPYLLLGVVLWYAVLKSGVHATLAGVLLALTIPARPRVG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 248 ADEV---PLDRLEHAINPWVTFMILPLFGFANAGVALSGMTMNDLLSPVPVGVALGLFLGKQAGIFGLSLLAVSLGLAKR 324
Cdd:COG3004  241 GEEEaesPLERLEHALHPWVAFLILPLFAFANAGVSLSGLSLAALTSPVTLGIALGLVLGKPLGIFGFSWLAVKLGLARL 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490298611 325 PEKSTWLQVYGVSVLCGIGFTMSLFIGNLAFTGSPLLvDEVKVGVLAGSILAALAGILILRFAPSKQ 391
Cdd:COG3004  321 PAGVSWRQLYGVGLLAGIGFTMSLFIAELAFPDPELL-DAAKLGILLGSLLAAVLGYLLLRLRLRRK 386
Na_H_antiport_1 pfam06965
Na+/H+ antiporter 1; This family contains a number of bacterial Na+/H+ antiporter 1 proteins. ...
18-383 1.10e-169

Na+/H+ antiporter 1; This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyze the exchange of H+ for Na+ in a manner that is highly dependent on the pH.


Pssm-ID: 429217  Cd Length: 378  Bit Score: 478.82  E-value: 1.10e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611   18 NFFSSPVAGGIVLIIASAAAIIVANSPLREGYETLLKYKTA--------GLSVEHWINDALMAVFFMMVGLEIKRELVTG 89
Cdd:pfam06965   2 RFLRSEAAGGILLLAAAVLALIWANSPLADSYEALWHTPLGvgfgglslSLSLHHWINDGLMAIFFFVVGLEIKRELLVG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611   90 QLATWSQRALPGFAALGGLAVPALIYVGFNAGHdETLSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALAILDDMG 169
Cdd:pfam06965  82 ELSSPRKAALPVIAALGGMVVPALIYLAFNAGG-PGARGWAIPMATDIAFALGVLALLGKRVPASLRVFLLALAIVDDLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  170 AVAIIALFYTSNISLLMLGGAAAMVALLFSLNRAGVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLRTR-NAA 248
Cdd:pfam06965 161 AILVIALFYTSGLSLLALLAAAAILAVLLLLNRLGVRRLWPYLLLGVVLWVAVLKSGVHATIAGVLLALLIPARPPaRES 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  249 DEV--PLDRLEHAINPWVTFMILPLFGFANAGVALSGMTMNDLL-SPVPVGVALGLFLGKQAGIFGLSLLAVSLGLAKRP 325
Cdd:pfam06965 241 REAisPLERLEHALHPWVAFLILPLFALANAGVSLSGSGLGALLtSPVTLGIALGLVLGKPLGIFGFSWLAVKLGLARLP 320
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 490298611  326 EKSTWLQVYGVSVLCGIGFTMSLFIGNLAFTGSPLLVDEVKVGVLAGSILAALAGILI 383
Cdd:pfam06965 321 EGVTWRQLLGVGLLAGIGFTMSLFIAELAFDDELELLDEAKLGILLGSLLAAVLGYLV 378
nhaA PRK09561
sodium/proton antiporter NhaA;
12-392 3.04e-155

sodium/proton antiporter NhaA;


Pssm-ID: 181955  Cd Length: 388  Bit Score: 442.78  E-value: 3.04e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  12 VIKPVSNFFSSPVAGGIVLIIASAAAIIVANSPLREGYETLLK----YKTAGLSVE----HWINDALMAVFFMMVGLEIK 83
Cdd:PRK09561   1 MMKHIRRFLSSEASGGILLIIAAALAMLMANSPTSGWYQDFLEtpvqLRVGALEINkpllLWINDGLMAVFFLLIGLEVK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  84 RELVTGQLATWSQRALPGFAALGGLAVPALIYVGFNAGHDETLSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALA 163
Cdd:PRK09561  81 RELLEGSLASRRQAALPVIAAIGGMLVPALIYLLFNYADPVTREGWAIPAATDIAFALGVLALLGSRVPVALKIFLLALA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 164 ILDDMGAVAIIALFYTSNISLLMLGGAAAMVALLFSLNRAGVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLR 243
Cdd:PRK09561 161 IIDDLGAIVIIALFYTSDLSMVSLGVAAVAIAVLAVLNLCGVRRTSVYILVGVVLWVAVLKSGVHATLAGVIVGFFIPLK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 244 TRNAadEVPLDRLEHAINPWVTFMILPLFGFANAGVALSGMTMNDLLSPVPVGVALGLFLGKQAGIFGLSLLAVSLGLAK 323
Cdd:PRK09561 241 EKHG--RSPAERLEHGLHPWVAFLILPLFAFANAGVSLQGVTLDGLTSPLPLGIALGLFIGKPLGIFLFSWLAVKLKLAK 318
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 324 RPEKSTWLQVYGVSVLCGIGFTMSLFIGNLAFTGS-PLLVDEVKVGVLAGSILAALAGILILRFAPSKQV 392
Cdd:PRK09561 319 LPEGTTFKQIYAVGVLCGIGFTMSIFIASLAFGGVdPELINYAKLGILIGSLLSAVIGYSWLRKVLPASV 388
NhaA TIGR00773
Na+/H+ antiporter NhaA; These proteins are members of the NhaA Na+:H+ Antiporter (NhaA) Family ...
19-384 2.98e-130

Na+/H+ antiporter NhaA; These proteins are members of the NhaA Na+:H+ Antiporter (NhaA) Family (TC. 2.A.33). The Escherichia coli NhaA protein probably functions in the regulation of the internal pH when the external pH is alkaline. It also uses the H+ gradient to expel Na+ from the cell. Its activity is highly pH dependent. Only the E. coli protein is functionally and structurally well characterized. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273264  Cd Length: 373  Bit Score: 378.73  E-value: 2.98e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611   19 FFSSPVAGGIVLIIASAAAIIVANSPLREGYETLLK--------YKTAGLSVEHWINDALMAVFFMMVGLEIKRELVTGQ 90
Cdd:TIGR00773   1 FFKSESAGGILLVIAAALAMVMANSALSEWYHDFLHtpvqlqigSFVIGKSLLHWINDGLMAVFFLLIGLEVKRELLEGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611   91 LATWSQRALPGFAALGGLAVPALIYVGFNAGHDETLSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALAILDDMGA 170
Cdd:TIGR00773  81 LSSLRQAIFPVIAAIGGMIAPALIYLAFNANDPITREGWAIPAATDIAFALGVMALLGKRVPLALKIFLLALAIIDDLGA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  171 VAIIALFYTSNISLLMLGGAAAMVALLFSLNRAGVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLRTRNaaDE 250
Cdd:TIGR00773 161 IVIIALFYTNDLSMAALLVAAVAIAVLAVLNRCGVRRLGPYMLVGVILWFAVLKSGVHATLAGVIIGFFIPLKGKK--GE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  251 VPLDRLEHAINPWVTFMILPLFGFANAGVALSGMTMNDLLSPVPVGVALGLFLGKQAGIFGLSLLAVSLGLAKRPEKSTW 330
Cdd:TIGR00773 239 SPLKRLEHVLHPWVAYLILPLFAFANAGVSLQGVSLNGLTSMLPLGIILGLLIGKPLGIFLFSWIAVKLKLAKLPEGINF 318
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 490298611  331 LQVYGVSVLCGIGFTMSLFIGNLAFTG-SPLLVDEVKVGVLAGSILAALAGILIL 384
Cdd:TIGR00773 319 KQIFAVGVLCGIGFTMSIFIASLAFGSvDPELITWAKLGILLGSTTSAVLGYSWL 373
nhaA PRK14855
pH-dependent sodium/proton antiporter; Provisional
15-393 1.60e-108

pH-dependent sodium/proton antiporter; Provisional


Pssm-ID: 237836  Cd Length: 423  Bit Score: 325.28  E-value: 1.60e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  15 PVSNFFSSPVAGGIVLIIASAAAIIVANSPLREGYETLLKYKTA--------GLSVEHWINDALMAVFFMMVGLEIKREL 86
Cdd:PRK14855   8 PFQRFVESEAFAGLLLVGTAVAAFIWANSPWREGYFTLQHTHLAlslggwslDLSLEHWVNDGLMAVFFLLVGLEIKREL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  87 VTGQLATWSQRALPGFAALGGLAVPALIYVGFNAGhDETLSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALAILD 166
Cdd:PRK14855  88 LIGELSSPRQAALAVVAALGGMLVPAALYTALNAG-GPGASGWGVPMATDIAFALGVLALLGSRVPLGLKVFLTALAIVD 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 167 DMGAVAIIALFYTSNISLLMLGGAAAMVALLFSLNRAGVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLRTRN 246
Cdd:PRK14855 167 DLGAVLVIALFYTSGLNLLALLLAALTWALALLAGRLGVTSLKIYAVLGALLWFFVLKSGLHPTVAGVLLALAVPIRRRD 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 247 AADEV-------------------------------PLDRLEHAINPWVTFMILPLFGFANAGVALSGMTmndlLSPVPV 295
Cdd:PRK14855 247 PLPYLaslldaaapgrpevvgarlrdledlleraqsPLHRLEHALHPWSTFLILPVFALFNAGVSVSGGG----LGTVSL 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 296 GVALGLFLGKQAGIFGLSLLAVSLGLAKRPEKSTWLQVYGVSVLCGIGFTMSLFIGNLAFTGSPLLvDEVKVGVLAGSIL 375
Cdd:PRK14855 323 GVFLGLLLGKPLGVVGGAWLAVRLGLASLPRRVNWLHMLGAGLLAGIGFTMSLFISNLAFADAALL-TQAKLGVLAASVL 401
                        410
                 ....*....|....*...
gi 490298611 376 AALAGILILRFAPSKQVR 393
Cdd:PRK14855 402 AALLGAGWLWWAVRGQPG 419
nhaA PRK14856
sodium/proton antiporter NhaA;
17-384 7.52e-102

sodium/proton antiporter NhaA;


Pssm-ID: 184858  Cd Length: 438  Bit Score: 308.65  E-value: 7.52e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  17 SNFFSSPVAGGIVLIIASAAAIIVANSPLREGYETLLKYKTA--------GLSVEHWINDALMAVFFMMVGLEIKRELVT 88
Cdd:PRK14856  15 KNFIKSESFGGIFLFLNAVLAMVVANSFLKESYFALWHTPFGfqigdffiGFSLHNWIDDVLMALFFLMIGLEIKRELLF 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  89 GQLATWSQRALPGFAALGGLAVPALIYVGFNAGHDETlSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALAILDDM 168
Cdd:PRK14856  95 GELSSFKKASFPVIAALGGMIAPGLIYFFLNADTPSQ-HGFGIPMATDIAFALGVIMLLGKRVPTALKVFLITLAVADDL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 169 GAVAIIALFYTSNISLLMLGGAAAMVALLFSLNRAGVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLRTRNAA 248
Cdd:PRK14856 174 GAIVVIALFYTTNLKFAWLLGALGVVLVLAVLNRLNVRSLIPYLLLGVLLWFCVHQSGIHATIAAVVLAFMIPVKIPKDS 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 249 DEV--------------------------------------PLDRLEHAINPWVTFMILPLFGFANAGVALSGmTMNDLL 290
Cdd:PRK14856 254 KNVellelgkryaetssgalltkeqqeilhsieekasalqsPLERLEHFLAPISGYFIMPLFAFANAGVSVDS-SINLEV 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 291 SPVPVGVALGLFLGKQAGIFGLSLLAVSLGLAKRPEKSTWLQVYGVSVLCGIGFTMSLFIGNLAFT-GSPLLVDEVKVGV 369
Cdd:PRK14856 333 DKVLLGVILGLCLGKPLGIFLITFISEKLKITARPKGISWWHILGAGLLAGIGFTMSMFISNLAFTsEHKDAMEVAKIAI 412
                        410
                 ....*....|....*
gi 490298611 370 LAGSILAALAGILIL 384
Cdd:PRK14856 413 LLGSLISGIIGALYL 427
nhaA PRK14854
pH-dependent sodium/proton antiporter; Provisional
17-386 6.08e-97

pH-dependent sodium/proton antiporter; Provisional


Pssm-ID: 184856  Cd Length: 383  Bit Score: 294.06  E-value: 6.08e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  17 SNFFSSPVAGGIVLIIASAAAIIVANSPLREGYETLL----KYKTAGLSVE----HWINDALMAVFFMMVGLEIKRELVT 88
Cdd:PRK14854   3 ASQKNQELIGGLILFSAALLAIVVNNSPLASYYAMLEtinvKLGIENLVIDknlmHWINDGLMAIYFLYIGLEIKREIIV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611  89 GQLATWSQRALPGFAALGGLAVPALIYVGFNAgHDETLSGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSALAILDDM 168
Cdd:PRK14854  83 GTLSKPSNIITPAIAAFAGLAMPSLIYLSINH-DIKVINGWAIPSATDIAFTLGILALLGTRVPAKLKLLVITIAIFDDI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 169 GAVAIIALFYTSNISLLMLGGAAAMVALLFSLNRA-GVTRLLPYLLTGGVLWFFMLQSGVHATVAGILLAFFIPLRTRNa 247
Cdd:PRK14854 162 AAIAIIAIFYTKSLSLLSLSLGTLFILAMIICNRIfKINRSSVYVVLGFFAWFCTIKSGVHATLAGFTTALCIPFREND- 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298611 248 aDEVPLDRLEHAINPWVTFMILPLFGFANAGVALSGMTMNDLLSPVPVGVALGLFLGKQAGIFGLSLLAVSLGLAKRPEK 327
Cdd:PRK14854 241 -KDSPANFMEDSLHPWIIYFILPVFAFANAGISFSGISFSILFEPITLGIILGLFVGKQLGIFSILAVFKKLKWFKLGES 319
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 490298611 328 STWLQVYGVSVLCGIGFTMSLFIGNLAFTGSPLLvDEVKVGVLAGSILAALAGILILRF 386
Cdd:PRK14854 320 FSNLQLYGISLLCGIGFTMSLFIGVLAFNDTHLL-NAIKIGVVVGSVLSGFFGYIVLRF 377
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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