TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced in response to a peptide sex pheromone, cPD1, secreted from plasmid-free recipient cells. cPD1 is taken up by a pPD1 donor cell and binds to an intracellular receptor, TraA. Once a recipient cell acquires pPD1, it starts to produce an inhibitor of cPD1, termed iPD1, which functions as a TraA antagonist and blocks self-induction in donor cells. TraA transduces the signal of cPD1 to the mating response.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298994    1 MNAVLSVQGSAVSEKTKPSFMSRVFNKKKALKVAKVALPVAAVAAFFPDAAMATTTATDLMKSGDATVKGTFGKQSSVVK 80
Cdd:pfam05513   1 MNAILSVQGAAAPEKKKPSFLSRTFNKKKALKLAKAAIPAAALAAFFPDAAMAAGGAQDLMASGDATVKATFGKDSSAVK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 490298994   81 WVVLAEVVAGGIMYMMTKNVKFLFGFAIISTFITIGMSVA 120
Cdd:pfam05513  81 WVILAEVLAGAIMYMMTKNVKFLAGFAIISTFIAIGMAVA 120

TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced in response to a peptide sex pheromone, cPD1, secreted from plasmid-free recipient cells. cPD1 is taken up by a pPD1 donor cell and binds to an intracellular receptor, TraA. Once a recipient cell acquires pPD1, it starts to produce an inhibitor of cPD1, termed iPD1, which functions as a TraA antagonist and blocks self-induction in donor cells. TraA transduces the signal of cPD1 to the mating response.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298994    1 MNAVLSVQGSAVSEKTKPSFMSRVFNKKKALKVAKVALPVAAVAAFFPDAAMATTTATDLMKSGDATVKGTFGKQSSVVK 80
Cdd:pfam05513   1 MNAILSVQGAAAPEKKKPSFLSRTFNKKKALKLAKAAIPAAALAAFFPDAAMAAGGAQDLMASGDATVKATFGKDSSAVK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 490298994   81 WVVLAEVVAGGIMYMMTKNVKFLFGFAIISTFITIGMSVA 120
Cdd:pfam05513  81 WVILAEVLAGAIMYMMTKNVKFLAGFAIISTFIAIGMAVA 120

type IV conjugative transfer system pilin TraA; TraA is the single structural subunit of the pilus found in type IV conjugative transfer systems. This family is generally found in gammaproteobacteria. The pilins show considerable heterogeneity among the different conjugative plasmit types. All of them however contain an N-terminal part which is cleaved off by a leader peptidase (LepB, or similar) to result in a 68-78 amino acid product. Pilins may be further processed by acetylation (in F-like systems by the TraX protein) or by cyclization (in P-like systems by the TraF protein).

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490298994   59 DLMKSGDATVKGTFGKQSSVVKWVVLAEVVAGGIMYMMTKNVKFLF-GFAIISTFITIGMSVAGY 122
Cdd:TIGR02758  29 DLFAGGKATVKATAGKDSSVEMAMILAGLLVAAVMGFMTKNWFAALgGFAGGSIFWNVGMALVGL 93

TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced in response to a peptide sex pheromone, cPD1, secreted from plasmid-free recipient cells. cPD1 is taken up by a pPD1 donor cell and binds to an intracellular receptor, TraA. Once a recipient cell acquires pPD1, it starts to produce an inhibitor of cPD1, termed iPD1, which functions as a TraA antagonist and blocks self-induction in donor cells. TraA transduces the signal of cPD1 to the mating response.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490298994    1 MNAVLSVQGSAVSEKTKPSFMSRVFNKKKALKVAKVALPVAAVAAFFPDAAMATTTATDLMKSGDATVKGTFGKQSSVVK 80
Cdd:pfam05513   1 MNAILSVQGAAAPEKKKPSFLSRTFNKKKALKLAKAAIPAAALAAFFPDAAMAAGGAQDLMASGDATVKATFGKDSSAVK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 490298994   81 WVVLAEVVAGGIMYMMTKNVKFLFGFAIISTFITIGMSVA 120
Cdd:pfam05513  81 WVILAEVLAGAIMYMMTKNVKFLAGFAIISTFIAIGMAVA 120

type IV conjugative transfer system pilin TraA; TraA is the single structural subunit of the pilus found in type IV conjugative transfer systems. This family is generally found in gammaproteobacteria. The pilins show considerable heterogeneity among the different conjugative plasmit types. All of them however contain an N-terminal part which is cleaved off by a leader peptidase (LepB, or similar) to result in a 68-78 amino acid product. Pilins may be further processed by acetylation (in F-like systems by the TraX protein) or by cyclization (in P-like systems by the TraF protein).

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490298994   59 DLMKSGDATVKGTFGKQSSVVKWVVLAEVVAGGIMYMMTKNVKFLF-GFAIISTFITIGMSVAGY 122
Cdd:TIGR02758  29 DLFAGGKATVKATAGKDSSVEMAMILAGLLVAAVMGFMTKNWFAALgGFAGGSIFWNVGMALVGL 93