|
Name |
Accession |
Description |
Interval |
E-value |
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
1-421 |
0e+00 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 849.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 1 MFALADVNSFYASCERVFRPDLKGKPIVVLSNNDGNVIARSAEAKPW-IKMGTPWFQIKNERYPEKIYAFSSNYELYASM 79
Cdd:PRK03609 1 MFALCDVNSFYASCETVFRPDLRGKPVVVLSNNDGCVIARSAEAKALgIKMGDPWFKQKDLFRRCGVVCFSSNYELYADM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 80 SARVMNCLEELAPRVEQYSIDEMFLDLTGVEHCMGLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEW-KQF 158
Cdd:PRK03609 81 SNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWqRQT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 159 RGVLALTrgNPQRTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDLALTNPAFIRKNFSVVLERTVRELNGESCLSLE 238
Cdd:PRK03609 161 GGVVDLS--NLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPCLSLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 239 EAPPTKQQIVCSRSFGVKITEYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFAIKEPYYGNVATEKLLTPTQD 318
Cdd:PRK03609 239 EFAPTKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSASVKLLTPTQD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 319 TRDIIAAATMALERIWRDGHRYAKAGVMLNDFTGSGVSQLQLFDERPPRPHSAELMRVLDGIN-NSGLGKVWFAGRGIAP 397
Cdd:PRK03609 319 SRDIIAAATRALDAIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMKVLDTLNaKSGKGTLYFAGQGIAQ 398
|
410 420
....*....|....*....|....
gi 490302257 398 SWQMKRDMLSPAYTTRWRDIPVAR 421
Cdd:PRK03609 399 QWQMKREMLSPRYTTRWSDLLRVK 422
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
3-349 |
8.03e-178 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 499.38 E-value: 8.03e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 3 ALADVNSFYASCERVFRPDLKGKPIVVLSNNDGNVIARSAEAKP-WIKMGTPWFQIKnERYPE-KIYAFSSNYELYASMS 80
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVIARSPEAKAlGIKMGSPYFKVP-DLLERhGVAVFSSNYALYGDMS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 81 ARVMNCLEELAPRVEQYSIDEMFLDLTGVEHCMGLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEWKQFRG 160
Cdd:cd01700 80 RRIMSILERFSPDVEVYSIDESFLDLTGSLRFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAKKKNPYGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 161 VLALTRgnPQRTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDLALTNPAFIRKNFSVVLERTVRELNGESCLSLEEA 240
Cdd:cd01700 160 VVDLTD--EEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLEEY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 241 PPTKQQIVCSRSFGVKITEYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFAIKEPYYGnvATEKLLTPTQDTR 320
Cdd:cd01700 238 PPPKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPKYYS--ATNTLPYPTNDTR 315
|
330 340
....*....|....*....|....*....
gi 490302257 321 DIIAAATMALERIWRDGHRYAKAGVMLND 349
Cdd:cd01700 316 EIVKAALRLLYAIYRPGYAYRKAGVMLSD 344
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
1-347 |
7.48e-126 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 367.16 E-value: 7.48e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 1 MFALADVNSFYASCERVFRPDLKGKPIVVLS-NNDGNVIARSAEAKPW-IKMGTPWFQIKnERYPEKIYaFSSNYELYAS 78
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGdNNRGVVAAASYEARAFgVRSGMPLFQAR-RLCPDLVV-LPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 79 MSARVMNCLEELAPRVEQYSIDEMFLDLTGVEHCMG-LEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEwkq 157
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGsAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKP--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 158 fRGVLALTrgnPQRTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDLALTNPAFIRKNFSVVLERTVRELNGESCLSL 237
Cdd:COG0389 157 -DGLTVIP---PGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 238 EEAPPtKQQIVCSRSFGVKITEYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFAIkepyygNVATEKLLTPTQ 317
Cdd:COG0389 233 EPRRP-RKSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRT------TTRSRTLPEPTD 305
|
330 340 350
....*....|....*....|....*....|
gi 490302257 318 DTRDIIAAATMALERIWRDGHRYAKAGVML 347
Cdd:COG0389 306 DTAELLRAARELLERIYRPGRPVRLLGVRL 335
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
6-336 |
1.53e-61 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 202.37 E-value: 1.53e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 6 DVNSFYASCERVFRPDLKGKPIVVLSNNDGNVIArSA--EAKPW-IKMGTPWFQIKnERYPEKIYAfSSNYELYASMSAR 82
Cdd:cd03586 4 DMDAFYASVEQRDNPELKGKPVAVGGSSDRGVVS-TAsyEARKFgVRSAMPIFQAK-KLCPNLIFV-PPRFDKYREVSRQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 83 VMNCLEELAPRVEQYSIDEMFLDLTGVEHCMGL-EDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQwaskEWKQFRGV 161
Cdd:cd03586 81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSaTEIAKEIRARIREETGLTASAGIAPNKFLAKIAS----DLNKPNGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 162 LALTrgnPQRTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDLALTNPAFIRKNFSVVLERTVRELNGESCLSLEEAP 241
Cdd:cd03586 157 TVIP---PEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 242 PTKqQIVCSRSFGVKITEYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFAIKepyygnVATEKLLTPTQDTRD 321
Cdd:cd03586 234 ERK-SIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTR------TRSRTLPEPTDDAED 306
|
330
....*....|....*
gi 490302257 322 IIAAATMALERIWRD 336
Cdd:cd03586 307 IYELALELLEELLDG 321
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
6-347 |
1.96e-48 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 168.31 E-value: 1.96e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 6 DVNSFYASCERVFRPDLKGKPIVVLSNNDGN--VIARSAEAKPW-IKMGTPWFQIKnERYPEKIYaFSSNYELYASMSAR 82
Cdd:cd00424 4 DFDNFFASVEQLARPELKGRPVVVVPFNSDStcVIACSYEARKYgVKRGMPVREAR-KMCPNLIL-VPARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 83 VMNCLEELAPRVEQYSIDEMFLDLTGVEHCMGL-EDFGRQLRQHVYDCTR-LTIGVGAGPTKTLAKSAQWASKewkqfRG 160
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGSARLLGLgSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAK-----PD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 161 VLALTRGNPQrTRKLLSLqPVEEIWGVGNRIARKLNVLGIKTALDLALTNP-AFIRKNFSVVLERTVRELNGESCLSLEE 239
Cdd:cd00424 157 GLTILDPEDL-PGFLSKL-PLTDLPGIGAVTAKRLEAVGINPIGDLLAASPdALLALWGGVSGERLWYALRGIDDEPLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 240 APPtKQQIVCSRSFGVKITEYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFAIKEPYYGNVATEKLLTPTQDt 319
Cdd:cd00424 235 PRP-RKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDGRWSGHADIPSRSAPRPISTED- 312
|
330 340
....*....|....*....|....*...
gi 490302257 320 RDIIAAATMALERIWRDGHRYAKAGVML 347
Cdd:cd00424 313 GELLHALDKLWRALLDDKGPRRLRRLGV 340
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
4-382 |
7.63e-45 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 160.55 E-value: 7.63e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 4 LADVNSFYASCERVFRPDLKGKPIVVL---SNNDGNVIARSAEAKPW-IKMGTPWFQIKnERYPEkIYAFSSNYELYASM 79
Cdd:PRK03103 7 LVDMQSFYASVEKAANPELKGRPVIVSgdpERRSGVVLAACPLAKAYgVKTAERLWEAQ-QKCPD-LVVVKPRMQRYIDV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 80 SARVMNCLEELAPRVEQYSIDEMFLDLTGVEHCMG-LEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSA--QWASKEWK 156
Cdd:PRK03103 85 SLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFGsPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMAcdNFAKKNPD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 157 qfrGVLALTRGNPQrtRKLLSLqPVEEIWGVGNRIARKLNVLGIKTALDLALTNPAFIRKNFSVVLERTVRELNGescls 236
Cdd:PRK03103 165 ---GLFTLDKEDVP--ADLWPL-PVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANG----- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 237 LEEAPPTKQQIVCSRSFGVKIT------EYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFAIKEPYYGNVate 310
Cdd:PRK03103 234 IDYSPVTPHSLDRQKAIGHQMTlprdyrGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTGFSRQM--- 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490302257 311 KLLTPTQDTRDIIAAATMALERIWrDGHRYAKAGVMLNDFTGSGVSQLQLFDERPPRphsAELMRVLDGINN 382
Cdd:PRK03103 311 TLPEPTNLAMEVYEAACKLFHRHW-DGKPVRRVGVTLSNLVSDDVWQLSLFGDRERK---RSLGYVMDDIKN 378
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
6-148 |
4.58e-42 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 145.41 E-value: 4.58e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 6 DVNSFYASCERVFRPDLKGKPIVVLSNNDGN-VIARSAEAKPW-IKMGTPWFQIKnERYPEkIYAFSSNYELYASMSARV 83
Cdd:pfam00817 2 DMDAFFASVELLRDPELKGKPVAVGGGNGRGiVAAASYEARKYgVRSGMPVFEAK-KLCPN-LIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490302257 84 MNCLEEL-APRVEQYSIDEMFLDLTGVEHCMGLE-DFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSA 148
Cdd:pfam00817 80 FEILRRFsTPKVEQASIDEAFLDLTGLEKLFGAEeALAKRLRREIAEETGLTCSIGIAPNKLLAKLA 146
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
6-362 |
1.41e-36 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 138.24 E-value: 1.41e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 6 DVNSFYASCERVFRPDLKGKPIVVLSN---NDGNVIARSAEAKPW-IKMGTPWFQIKnERYPEKIyAFSSNYELYASMSA 81
Cdd:PRK01810 11 DMNSFFASVEIAYDPSLQGKPLAVAGNekeRKGIIVTCSYEARAYgIRTTMPLWEAK-RLCPQLI-VRRPNFDRYREASR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 82 RVMNCLEELAPRVEQYSIDEMFLDLTGVEHCMGLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQwaskEWKQFRGV 161
Cdd:PRK01810 89 QMFQILSEFTPLVQPVSIDEGYLDITDCYALGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMAS----DMKKPLGI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 162 LAL-TRGNPqrtRKLLSLqPVEEIWGVGNRIARKLNVLGIKTALDLALTNPAFIRKNFSVVLERTVRELNGEsclslEEA 240
Cdd:PRK01810 165 TVLrKRDVP---EMLWPL-PVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGI-----DDR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 241 PPTKQQIVCSRSFGVKIT------EYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFAikepyygNVA-TEKLL 313
Cdd:PRK01810 236 PVDPEAIYQFKSVGNSTTlshdmdEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRR-------TITrSKTLK 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 490302257 314 TPTQDTRDIIAAATMALERIWrDGHRYAKAGVMLNDFTG--SGVSQLQLFD 362
Cdd:PRK01810 309 NPIWEKRDIFQAASRLFKQHW-NGDPVRLLGVTATDLEWktEAVKQLDLFS 358
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
6-336 |
4.26e-30 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 118.97 E-value: 4.26e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 6 DVNSFYASCERVFRPDLKGKPIVVLSNND-----GNVIARSAEAKPW-IKMGTPwFQIKNERYPEKIYaFSSNYELYASM 79
Cdd:PRK03352 11 DLDQFIAAVELLRRPELAGLPVIVGGNGDpteprKVVTCASYEARAFgVRAGMP-LRTAARRCPDAVF-LPSDPAAYDAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 80 SARVMNCLEELAPRVEQYSIDEMFLdltGVEhCMGLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEwkqfR 159
Cdd:PRK03352 89 SEEVMATLRDLGVPVEVWGWDEAFL---GVD-TDDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKP----A 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 160 GVLALTRGNpqrTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDLALTNPAFIRKNFS-------VVLERTVrelnGE 232
Cdd:PRK03352 161 GVFRLTDAN---WMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpttgpwlLLLARGG----GD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 233 SCLSLEEAPPTkqqivcSRS----FGVKITEYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFaikepyYGNVA 308
Cdd:PRK03352 234 TEVSAEPWVPR------SRSrevtFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATF------YTRTK 301
|
330 340
....*....|....*....|....*...
gi 490302257 309 TEKLLTPTQDTRDIIAAATMALERIWRD 336
Cdd:PRK03352 302 IRKLPEPTTDPDVIEAAALDVLDRFELD 329
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
6-298 |
1.91e-28 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 114.43 E-value: 1.91e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 6 DVNSFYASCERVFRPDLKGKPIVV--LSNNdGNVIARSAEAKPW-IKMGTPWFQIKnERYPEKIYaFSSNYELYASMSAR 82
Cdd:PRK14133 9 DMDAFFASVEQMDNPKLKGKPVIVggISER-GVVSTCSYEARKYgVHSAMPVFMAK-KRCPHGIF-LPVRHERYKEVSKN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 83 VMNCLEELAPRVEQYSIDEMFLDLTGVEHcmGLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQwaskEWKQFRGVL 162
Cdd:PRK14133 86 IFKILYEVTPIVEPVSIDEAYLDITNIKE--EPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLAS----DWNKPDGIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 163 ALTRgnpQRTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDL-ALTNPAFIR---KNFSVVLERtVRELNGESCLSLE 238
Cdd:PRK14133 160 IITE---DMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLlKLSREFLIEyfgKFGVEIYER-IRGIDYREVEVSR 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 239 EapptKQQIVCSRSFGVKITEYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFA 298
Cdd:PRK14133 236 E----RKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQ 291
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
6-326 |
1.89e-27 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 113.49 E-value: 1.89e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 6 DVNSFYASCERVFRPDLKGKPIVV--LSNNdGNVIARSAEAKpwiKMGT----PWFQIKnERYPEKIYAFSSNYELYASM 79
Cdd:PRK03348 11 DMDAFFASVEQLTRPTLRGRPVLVggLGGR-GVVAGASYEAR---VFGArsamPMHQAR-RLVGNGAVVLPPRFVVYRAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 80 SARVMNCLEELAPRVEQYSIDEMFLD---LTGVEhCMGLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEwk 156
Cdd:PRK03348 86 SRRVFDTLRELSPVVEQLSFDEAFVEpaeLAGAS-AEEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGLAKP-- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 157 qfRGVLALTrgnPQRTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDLALTNPAFIrknfsvvlertVRELNGESCLS 236
Cdd:PRK03348 163 --DGIRVVP---PGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEV-----------ANLLGATVGPA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 237 L------------EEAPPTKqQIVCSRSFGVKITEYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFAIKepyy 304
Cdd:PRK03348 227 LhrlargiddrpvAERAEAK-QISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTL---- 301
|
330 340
....*....|....*....|..
gi 490302257 305 gnVATEKLLTPTQDTRDIIAAA 326
Cdd:PRK03348 302 --TRSATLPYATDDAAVLAATA 321
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
5-380 |
6.83e-27 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 110.85 E-value: 6.83e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 5 ADVNSFYASCERVFRPDLKGKPIVVlsnNDGNVIARSAEAKPW-IKMGTPWFQIKnERYPEKIYAfSSNYELYASMSARV 83
Cdd:PRK03858 9 ADLDSFYASVEQRDDPALRGRPVIV---GGGVVLAASYEAKAYgVRTAMGGRQAR-RLCPQAVVV-PPRMSAYSRASKAV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 84 MNCLEELAPRVEQYSIDEMFLDLTGVEHCMGL-EDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEwkqfRGVL 162
Cdd:PRK03858 84 FEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTpVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKP----DGLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 163 ALtrgNPQRTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDLALTNpafirknfSVVLERTVRELNGE--SCLSLEEA 240
Cdd:PRK03858 160 VV---PPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELP--------ESALVSLLGPAAGRhlHALAHNRD 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 241 P------PTKQQIVCSRSFGVKITEYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFAikepyygnVATEK--L 312
Cdd:PRK03858 229 PrrvetgRRRRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDFT--------RATRShtL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490302257 313 LTPTQDTRDIIAAATMALERIWRD-GHRYAK-AGVMLNDFTGSGVSQLQL-FDerpPRPHSAELMRVLDGI 380
Cdd:PRK03858 301 PRPTASTATLLAAARDLVAAAAPLiAERGLTlVGFAVSNLDDDGAQQLELpFG---LRRPGSALDAALDAV 368
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
244-351 |
1.55e-25 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 99.56 E-value: 1.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 244 KQQIVCSRSFGVKITEYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFAikepyyGNVATEKLLTPTQDTRDII 323
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFR------TITRSVTLPSPTDDTDEIY 74
|
90 100
....*....|....*....|....*...
gi 490302257 324 AAATMALERIWRdGHRYAKAGVMLNDFT 351
Cdd:pfam11799 75 RAALRLLRRLYR-GRPVRLLGVSLSNLV 101
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
6-380 |
1.05e-23 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 102.32 E-value: 1.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 6 DVNSFYASCERVFRPDLKGKPIVVLSNNDGNV-----IAR-----SAeakpwikMgtPWFQIKnERYPEKIyAFSSNYEL 75
Cdd:PRK02794 42 DCDAFYASVEKRDNPELRDKPVIIGGGKRGVVstacyIARihgvrSA-------M--PMFKAL-KLCPDAV-VIKPDMEK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 76 YASMSARVMNCLEELAPRVEQYSIDEMFLDLTGVEHCMG------LEDFGRQLRQHVydctRLTIGVGAGPTKTLAKSAQ 149
Cdd:PRK02794 111 YVRVGREVRAMMQALTPLVEPLSIDEAFLDLSGTERLHGappavvLARFARRVEREI----GITVSVGLSYNKFLAKIAS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 150 WASKEwkqfRGVLALTRGNpqrTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDLALTNPAFIRKNFSVVLERTVREL 229
Cdd:PRK02794 187 DLDKP----RGFSVIGRAE---ALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 230 NGESCLSLEEAPPTKqQIVCSRSFGVKITEYESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPFAIKepyygnVAT 309
Cdd:PRK02794 260 RGIDDRKVSPDREAK-SVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLR------TRR 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490302257 310 EKLLTPTQdTRDIIAAATMALERIWRDGHRYAKAGVMLNDFT-GSGVSQLQLFDERPPRPHSAElmRVLDGI 380
Cdd:PRK02794 333 RTLEDPTQ-LADRIFRTARELLEKETDGTAFRLIGIGVSDLSpADEADPPDLLDPQATRRAAAE--RAIDAL 401
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
1-206 |
2.11e-21 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 94.47 E-value: 2.11e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 1 MFALADVNSFYASCERVFRPDLKGKPIVVL-----SNNDGNVIARSAEAKPW-IKMGTPWFQIKnERYPEKIYaFSSNYE 74
Cdd:PRK01216 2 IILFVDFDYFFAQVEEVLNPSLKGKPVVVCvysgrFEDSGAVATANYEARKLgIKAGMPIVEAK-KILPNAVY-LPMRKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 75 LYASMSARVMNCLEELAPRVEQYSIDEMFLDLTG-VEHCMGLEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAqwASK 153
Cdd:PRK01216 80 VYQQVSNRIMKLLREYSEKIEIASIDEAYLDISDkVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIA--ADM 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 490302257 154 EWKQFRGVLaltrgNPQRTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDL 206
Cdd:PRK01216 158 AKPNGIKVI-----DDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDT 205
|
|
| DUF4113 |
pfam13438 |
Domain of unknown function (DUF4113); Although the function is not known this domain occurs ... |
373-420 |
1.03e-19 |
|
Domain of unknown function (DUF4113); Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, pfam00817.
Pssm-ID: 463876 [Multi-domain] Cd Length: 49 Bit Score: 81.76 E-value: 1.03e-19
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 490302257 373 LMRVLDGINNS-GLGKVWFAGRGIAPSWQMKRDMLSPAYTTRWRDIPVA 420
Cdd:pfam13438 1 LMAALDAINRRyGRGTVRLAAQGLKRDWKMRREHLSPRYTTRWDELPVV 49
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
10-361 |
4.39e-18 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 84.79 E-value: 4.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 10 FYASCERVFRPDLKGKPIVVLSNNDG-------NVIAR---------SAEAKpwikmgtpwfqiknERYPEKIYaFSSNY 73
Cdd:PRK02406 4 FYAAVEMRDNPELRGKPVAVGGSPGRrgvistcNYEARkfgvrsampTAQAL--------------KLCPDLIF-VPGRF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 74 ELYASMSARVMNCLEELAPRVEQYSIDEMFLDLTGVEHCMGLE-DFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSaqwAS 152
Cdd:PRK02406 69 DVYKEVSRQIREIFRRYTDLIEPLSLDEAYLDVTDNKLCIGSAtLIAQEIRQDIFEELGLTASAGVAPNKFLAKI---AS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 153 kEWK----QFrgVLAltrgnPQRTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDLALTNPAFIRKNFSV---VL--- 222
Cdd:PRK02406 146 -DWNkpngLF--VIT-----PEEVDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKfgrRLyer 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 223 -----ERTV---RElngesclsleeapptKQQIVCSRSFGVKITEYESLRQAICQHAERASEKLRKeHQYCRHIS---VF 291
Cdd:PRK02406 218 argidERPVkpdRE---------------RKSVGVERTFAEDLYDLEACLAELPRLAEKLERRLER-AKPDKRIKtvgVK 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490302257 292 IKTSPFaikepyygNVAT-EKLLTPTQDTRDIIAAATMALERIWRDGHRYAKAGVMLndFTGSGVSQLQLF 361
Cdd:PRK02406 282 LKFADF--------QQTTkEHTADPLDKADLIELLAQALLRRLGGRGVRLLGVGVTL--LEPQLERQLLLD 342
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
6-302 |
2.21e-15 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 77.35 E-value: 2.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 6 DVNSFYASCERVFRPDLKGKPIVVLSNNDGNV-IAR-SAEAKPW-IKMGTpWFQIKNERYPEKIyAFSSNYELYASMSAR 82
Cdd:cd01701 53 DFDCFFVSVSIRNRPDLKGKPVAVCHGKGPNSeIAScNYEARSYgIKNGM-WVGQAKKLCPQLV-TLPYDFEAYEEVSLT 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 83 VMNCLEELAPRVEQYSIDEMFLDLTGVEHCMGL--EDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKsaqWASKEWKQfRG 160
Cdd:cd01701 131 FYEILASYTDNIEAVSCDEALIDITSLLEETYElpEELAEAIRNEIRETTGCSASVGIGPNILLAR---LATRKAKP-DG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 161 VLALTrgnPQRTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDLALtnpafiRKNFSVVLERTVRELNGES----CLS 236
Cdd:cd01701 207 QYHLS---AEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLEL------RSKTKEKLQKVLGPKTGEKlydyCRG 277
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490302257 237 LEEAPPTKQQ----IVCSRSFGV---KITEYESLRQAICQHAERASEKLRKEhqyCRHISVFIKT-SPFAIKEP 302
Cdd:cd01701 278 IDDRPVTGEKerksVSAEINYGIrftNVDDVEQFLQRLSEELSKRLEESNVT---GRQITLKLMKrAPGAPIEP 348
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
3-286 |
1.12e-11 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 65.80 E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 3 ALADVNSFYASCERVFRPDLKGKPIVVLSNNdgNVIA--------------RSAEAK-----------PWIKMGT----P 53
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWN--SIIAvsyaarafgvtrfmTIDEAKkkcpdlilahvATYKKGEdeadY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 54 WFQIKNERYpeKIyafssNYELYASMSARVMNCLEELAPRVEQYSIDEMFLDLTG--VEhcmgledfgrQLRQHVYDCTR 131
Cdd:cd01702 79 HENPSPARH--KV-----SLDPYRRASRKILNILKRFGDVVEKASIDEAYLDLGSriVE----------EIRQQVYDELG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 132 LTIGVGAGPTKTLAKSAQWASKEWKQfrgvlalTRGNPQRTRKLLSLQPVEEIWGVGNRIARKL-NVLGIKTALDLALTN 210
Cdd:cd01702 142 YTCSAGIAHNKMLAKLASGMNKPNAQ-------TILRNDAVASFLSSLPITSIRGLGGKLGEEIiDLLGLPTEGDVAGFR 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 211 --PAFIRKNFSVVLERTV-RELNGESCLSLEEAPPTKqQIVCSRSF-GVKITEYESLRQAICQHAERASEKLRK-EHQYC 285
Cdd:cd01702 215 ssESDLQEHFGEKLGEWLyNLLRGIDHEPVKPRPLPK-SMGSSKNFpGKTALSTEDVQHWLLVLASELNSRLEDdRYENN 293
|
.
gi 490302257 286 R 286
Cdd:cd01702 294 R 294
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
6-297 |
5.68e-11 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 64.27 E-value: 5.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 6 DVNSFYASCERVFRPDLKGKPIVVLSN---NDGNVIARSAEAKPwikmGTPWFqIKNERYPeKIYAFSSNYELYASMSAR 82
Cdd:PTZ00205 139 DMDMFYAAVEIKKHPEYAAIPLAIGTMtmlQTANYVARGRGIRQ----GMPGF-LALKICP-NLLILPPDFDAYNEESNT 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 83 VMNCLEELAPRVEQYSIDEMFLDLTG-VEHCMGL---EDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKEWKQF 158
Cdd:PTZ00205 213 VRRIVAEYDPNYISFGLDELTLEVSAyIERFEGTktaEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINKPNGQH 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 159 RGVLAlTRGNPQRTRKLLSLQPVEeiwGVGNRIARKLNVLGIKTALDLALTNPA----FIRKNFSVVLERTV-------- 226
Cdd:PTZ00205 293 DLNLH-TRGDVMTYVRDLGLRSVP---GVGKVTEALLKGLGITTLSDIYNRRVElcyiLHNNLFRFLLGASIgimqwpda 368
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490302257 227 -RELNGESClslEEAPPT-KQQIVCSRSFGVKITEyESLRQAICQHAERASEKLRKEHQYCRHISVFIKTSPF 297
Cdd:PTZ00205 369 aTAANTENC---EGATGGqRKAISSERSFTTPRTK-EGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASY 437
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
6-233 |
8.70e-08 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 54.01 E-value: 8.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 6 DVNSFYASCERVFRPDLKGKP-------IVVLSNndgnVIARSAEAKpwiKMgtpwFQIKN--ERYPEKIYAFSSNYELY 76
Cdd:cd01703 4 DLDCFYAQVEEIRDPSLKSKPlgiqqkyIVVTCN----YEARRLGVK---KL----MSIKDakEICPDLVLVNGEDLTPF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 77 ASMSARVMNCLEELAP--RVEQYSIDEMFLDLTGVEHCMGlEDFGRQLRQHVYDCTRLTIGVGAGPTKTLAKSAQWASKE 154
Cdd:cd01703 73 RDMSKKVYRLLRSYSWndRVERLGFDENFMDVTEMRLLVA-SHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKP 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490302257 155 WKQfrgvLALTRGNPQRTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDLALtNPAFIRKNFSVVLERTVRELNGES 233
Cdd:cd01703 152 NQQ----TTLLPPSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQE-FSNRNRQTVGAAPSLLELLLMVKE 225
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
77-259 |
4.76e-05 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 45.06 E-value: 4.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 77 ASMSARVMNCLEELAPRVEQYSIDEMFLDLTGVEHCMGLED-FGRQLRQHVyDCTRLTIGVGAGPTKTLAKsaqWASKew 155
Cdd:cd03468 75 ARALQELALWLLRFTPLVALDGPDGLLLDVTGCLHLFGGEDaLAASLRAAL-ATLGLSARAGIADTPGAAW---LLAR-- 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490302257 156 kqFRGVLALTRGNPQRTRKLLSLQPVEEIWGVGNRIARKLNVLGIKTALDLALTNPAFIRKNFSVVLERTVRELNGE--S 233
Cdd:cd03468 149 --AGGGRGVLRREALAAALVLLAPLPVAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRdpE 226
|
170 180
....*....|....*....|....*.
gi 490302257 234 CLSLEEAPPTKQQIVcSRSFGVKITE 259
Cdd:cd03468 227 PLLFSPPPPAFDFRL-ELQLEEPIAR 251
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
169-200 |
3.81e-04 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 37.38 E-value: 3.81e-04
10 20 30
....*....|....*....|....*....|..
gi 490302257 169 PQRTRKLLSLQPVEEIWGVGNRIARKLNVLGI 200
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| |
