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Conserved domains on  [gi|490304715|ref|WP_004199998|]
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MULTISPECIES: M15 family metallopeptidase [Burkholderia]

Protein Classification

M15 family metallopeptidase( domain architecture ID 13000805)

M15 family metallopeptidase of the zinc-binding metallopeptidase family, which contains mostly carboxypeptidases and dipeptidases, is involved in bacterial cell wall biosynthesis and metabolism

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
L-Ala-D-Glu_peptidase_like cd14845
L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu ...
 151-271 5.07e-39

L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.


:

Pssm-ID: 350620 [Multi-domain]  Cd Length: 126  Bit Score: 132.87  E-value: 5.07e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304715 151 ASRDWNLLDTDFRTRLLLVYKIMREQhGYEMALLEGYRSPERQNRLAQMG-----SNVTNAAAFQSYHQYGLAADNAFLR 225
Cdd:cd14845    1 SERRIAGLHPEVRAVVKELIELAEEE-GIDFRITEGYRSPARQAALYAQGrtkpgLIVTNARGGQSYHNYGLAVDIVPLV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 490304715 226 DGKLVISEKDPWAMRGYQLYGQVAEEVGLTWGGRWK-MMDLGHVEYH 271
Cdd:cd14845   80 NGKLSTGGADPWVSKAYQKLGEIAKSLGLEWGGDWKsFKDYPHFQLR 126
 
Name Accession Description Interval E-value
L-Ala-D-Glu_peptidase_like cd14845
L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu ...
 151-271 5.07e-39

L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.


Pssm-ID: 350620 [Multi-domain]  Cd Length: 126  Bit Score: 132.87  E-value: 5.07e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304715 151 ASRDWNLLDTDFRTRLLLVYKIMREQhGYEMALLEGYRSPERQNRLAQMG-----SNVTNAAAFQSYHQYGLAADNAFLR 225
Cdd:cd14845    1 SERRIAGLHPEVRAVVKELIELAEEE-GIDFRITEGYRSPARQAALYAQGrtkpgLIVTNARGGQSYHNYGLAVDIVPLV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 490304715 226 DGKLVISEKDPWAMRGYQLYGQVAEEVGLTWGGRWK-MMDLGHVEYH 271
Cdd:cd14845   80 NGKLSTGGADPWVSKAYQKLGEIAKSLGLEWGGDWKsFKDYPHFQLR 126
Peptidase_M15_4 pfam13539
D-alanyl-D-alanine carboxypeptidase; This family resembles VanY, pfam02557, which is part of ...
 204-270 6.14e-14

D-alanyl-D-alanine carboxypeptidase; This family resembles VanY, pfam02557, which is part of the peptidase M15 family.


Pssm-ID: 433291 [Multi-domain]  Cd Length: 67  Bit Score: 65.42  E-value: 6.14e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490304715  204 TNAAAFQSYHQYGLAADNAFLRDGklVISEKDPWAMRGY-QLYGQVAEEVGLTWGGRWKM-MDLGHVEY 270
Cdd:pfam13539   1 TGSKTGLSNHSYGLAIDINPLVNP--YWGAVLPENGIPYaDEVVEAFEKLGFEWGGDWKSfKDYMHFEY 67
YcbK COG3108
Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];
186-220 7.77e-03

Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];


Pssm-ID: 442342  Cd Length: 138  Bit Score: 36.05  E-value: 7.77e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 490304715 186 GYRSPERQNRLAQMGSNVtnaaAFQSYHQYGLAAD 220
Cdd:COG3108   64 GYRSPATNAMLRRRSRGV----AKNSLHMLGKAAD 94
 
Name Accession Description Interval E-value
L-Ala-D-Glu_peptidase_like cd14845
L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu ...
 151-271 5.07e-39

L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.


Pssm-ID: 350620 [Multi-domain]  Cd Length: 126  Bit Score: 132.87  E-value: 5.07e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304715 151 ASRDWNLLDTDFRTRLLLVYKIMREQhGYEMALLEGYRSPERQNRLAQMG-----SNVTNAAAFQSYHQYGLAADNAFLR 225
Cdd:cd14845    1 SERRIAGLHPEVRAVVKELIELAEEE-GIDFRITEGYRSPARQAALYAQGrtkpgLIVTNARGGQSYHNYGLAVDIVPLV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 490304715 226 DGKLVISEKDPWAMRGYQLYGQVAEEVGLTWGGRWK-MMDLGHVEYH 271
Cdd:cd14845   80 NGKLSTGGADPWVSKAYQKLGEIAKSLGLEWGGDWKsFKDYPHFQLR 126
Peptidase_M15_4 pfam13539
D-alanyl-D-alanine carboxypeptidase; This family resembles VanY, pfam02557, which is part of ...
 204-270 6.14e-14

D-alanyl-D-alanine carboxypeptidase; This family resembles VanY, pfam02557, which is part of the peptidase M15 family.


Pssm-ID: 433291 [Multi-domain]  Cd Length: 67  Bit Score: 65.42  E-value: 6.14e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490304715  204 TNAAAFQSYHQYGLAADNAFLRDGklVISEKDPWAMRGY-QLYGQVAEEVGLTWGGRWKM-MDLGHVEY 270
Cdd:pfam13539   1 TGSKTGLSNHSYGLAIDINPLVNP--YWGAVLPENGIPYaDEVVEAFEKLGFEWGGDWKSfKDYMHFEY 67
Peptidase_M15 cd14814
Metalloproteases including zinc D-Ala-D-Ala carboxypeptidase, L-Ala-D-Glu peptidase, L, ...
 174-270 1.16e-04

Metalloproteases including zinc D-Ala-D-Ala carboxypeptidase, L-Ala-D-Glu peptidase, L,D-carboxypeptidase, bacteriophage endolysins, and related proteins; This family summarizes zinc-binding metallopeptidases which are mostly carboxypeptidases and dipeptidases, and includes zinc-dependent D-Ala-D-Ala carboxypeptidases, VanX, L-Ala-D-Glu peptidase, L,D-carboxypeptidase and bacteriophage endolysins, amongst other family members. These peptidases belong to MEROPS family M15 which are involved in bacterial cell wall biosynthesis and metabolism.


Pssm-ID: 350615 [Multi-domain]  Cd Length: 111  Bit Score: 40.50  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304715 174 REQHGYEMALLEGYRSPERQNRLAQM---GSNVTNAAAF--QSYHQYGLAADnaflrdgklvISEKDPWAMR-GYQLYGQ 247
Cdd:cd14814   14 AGAEGRTLTINSGYRTYAQQLRLFAAkgkGSGGRRWAAPpgTSNHQWGLAID----------LGDGGGWRETqGYRWLKA 83

                         90       100
                 ....*....|....*....|....*..
gi 490304715 248 VAEEVGLTWGGRWKMM----DLGHVEY 270
Cdd:cd14814   84 NAPRYGFDNPGGARRGgafqEPWHWEY 110
YcbK COG3108
Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];
186-220 7.77e-03

Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];


Pssm-ID: 442342  Cd Length: 138  Bit Score: 36.05  E-value: 7.77e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 490304715 186 GYRSPERQNRLAQMGSNVtnaaAFQSYHQYGLAAD 220
Cdd:COG3108   64 GYRSPATNAMLRRRSRGV----AKNSLHMLGKAAD 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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