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Conserved domains on  [gi|490310625|ref|WP_004205332|]
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MULTISPECIES: carboxymuconolactone decarboxylase family protein [Klebsiella]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 10001777)

carboxymuconolactone decarboxylase (CMD) family protein similar to alkyl hydroperoxide reductase AhpD, which is required for the reduction of the AhpC active site cysteine residues to regenerate its enzyme activity; carboxymuconolactone d

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744
SCOP:  4000771

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 158-265 1.33e-25

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


:

Pssm-ID: 440364  Cd Length: 114  Bit Score: 97.33  E-value: 1.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490310625 158 KQRADTVEKNVGPISPGLVKFTADpLFLDLWQRPALTPRDRSLVTVSALIAAGQSAQIGYHLNRAMDNGLSAEEAGEVVA 237
Cdd:COG0599    8 EEYVPRALEALAEFAPEFAEAFEA-LFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALL 86

                         90       100
                 ....*....|....*....|....*...
gi 490310625 238 QAAFYAGWPNAFTAAPVVGEVLRSRESK 265
Cdd:COG0599   87 VAAVYAGFPAALNALRAALEVLEELGAA 114
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 39-136 4.23e-25

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


:

Pssm-ID: 440364  Cd Length: 114  Bit Score: 96.17  E-value: 4.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490310625  39 ADIQAVSPALARFgREAISNDLWQRDALSARDRSIVTMAMLIARNQPGELKHYIAVALDSGVTPAEVSEIITHLAFYAGW 118
Cdd:COG0599   16 EALAEFAPEFAEA-FEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYAGF 94

                         90
                 ....*....|....*...
gi 490310625 119 PNAMSAVSVAKAIFEARG 136
Cdd:COG0599   95 PAALNALRAALEVLEELG 112
 
Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 158-265 1.33e-25

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 97.33  E-value: 1.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490310625 158 KQRADTVEKNVGPISPGLVKFTADpLFLDLWQRPALTPRDRSLVTVSALIAAGQSAQIGYHLNRAMDNGLSAEEAGEVVA 237
Cdd:COG0599    8 EEYVPRALEALAEFAPEFAEAFEA-LFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALL 86

                         90       100
                 ....*....|....*....|....*...
gi 490310625 238 QAAFYAGWPNAFTAAPVVGEVLRSRESK 265
Cdd:COG0599   87 VAAVYAGFPAALNALRAALEVLEELGAA 114
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 39-136 4.23e-25

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 96.17  E-value: 4.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490310625  39 ADIQAVSPALARFgREAISNDLWQRDALSARDRSIVTMAMLIARNQPGELKHYIAVALDSGVTPAEVSEIITHLAFYAGW 118
Cdd:COG0599   16 EALAEFAPEFAEA-FEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYAGF 94

                         90
                 ....*....|....*...
gi 490310625 119 PNAMSAVSVAKAIFEARG 136
Cdd:COG0599   95 PAALNALRAALEVLEELG 112
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 46-130 1.17e-14

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 67.34  E-value: 1.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490310625   46 PALARFgREAISNDLWQRDALSARDRSIVTMAMLIARNQPGELKHYIAVALDSGVTPAEVSEIITHLAFYAGWPNAMSAV 125
Cdd:pfam02627   1 PELLAA-LTALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAAL 79


                  ....*
gi 490310625  126 SVAKA 130
Cdd:pfam02627  80 AAAEE 84
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 173-255 2.84e-14

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 66.57  E-value: 2.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490310625  173 PGLVKFTADPLFLDLWQrPALTPRDRSLVTVSALIAAGQSAQIGYHLNRAMDNGLSAEEAGEVVAQAAFYAGWPNAFTAA 252
Cdd:pfam02627   1 PELLAALTALAFGLLWD-GGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAAL 79


                  ...
gi 490310625  253 PVV 255
Cdd:pfam02627  80 AAA 82
 
Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 158-265 1.33e-25

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 97.33  E-value: 1.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490310625 158 KQRADTVEKNVGPISPGLVKFTADpLFLDLWQRPALTPRDRSLVTVSALIAAGQSAQIGYHLNRAMDNGLSAEEAGEVVA 237
Cdd:COG0599    8 EEYVPRALEALAEFAPEFAEAFEA-LFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALL 86

                         90       100
                 ....*....|....*....|....*...
gi 490310625 238 QAAFYAGWPNAFTAAPVVGEVLRSRESK 265
Cdd:COG0599   87 VAAVYAGFPAALNALRAALEVLEELGAA 114
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 39-136 4.23e-25

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 96.17  E-value: 4.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490310625  39 ADIQAVSPALARFgREAISNDLWQRDALSARDRSIVTMAMLIARNQPGELKHYIAVALDSGVTPAEVSEIITHLAFYAGW 118
Cdd:COG0599   16 EALAEFAPEFAEA-FEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYAGF 94

                         90
                 ....*....|....*...
gi 490310625 119 PNAMSAVSVAKAIFEARG 136
Cdd:COG0599   95 PAALNALRAALEVLEELG 112
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 46-130 1.17e-14

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 67.34  E-value: 1.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490310625   46 PALARFgREAISNDLWQRDALSARDRSIVTMAMLIARNQPGELKHYIAVALDSGVTPAEVSEIITHLAFYAGWPNAMSAV 125
Cdd:pfam02627   1 PELLAA-LTALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAAL 79


                  ....*
gi 490310625  126 SVAKA 130
Cdd:pfam02627  80 AAAEE 84
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 173-255 2.84e-14

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 66.57  E-value: 2.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490310625  173 PGLVKFTADPLFLDLWQrPALTPRDRSLVTVSALIAAGQSAQIGYHLNRAMDNGLSAEEAGEVVAQAAFYAGWPNAFTAA 252
Cdd:pfam02627   1 PELLAALTALAFGLLWD-GGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAAL 79


                  ...
gi 490310625  253 PVV 255
Cdd:pfam02627  80 AAA 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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