NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|490311494|ref|WP_004206189|]
View 

MULTISPECIES: DNA-binding transcriptional regulator SfsB [Klebsiella]

Protein Classification

helix-turn-helix domain-containing protein; LacI family DNA-binding transcriptional regulator( domain architecture ID 10013493)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family; HTH domain binds DNA and may function as a transcriptional regulator| LacI family DNA-binding transcriptional regulator functions as an activator or repressor by binding a specific effector ligand that either decreases (induction) or increases DNA-binding affinity (co-repression)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK10344 PRK10344
DNA-binding transcriptional regulator SfsB;
1-90 8.01e-60

DNA-binding transcriptional regulator SfsB;


:

Pssm-ID: 182394  Cd Length: 92  Bit Score: 177.08  E-value: 8.01e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490311494  1 MDKFIDWHPADIVAGLRKRGTSLAAESRRHGLSSSTLANALTRPWPKGELIIATALDTQPWVIWPSRYHDPVTHEFIDRT 80
Cdd:PRK10344  2 ESNFIDWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWVIWPSRYHDPQTHEFIDRT 81

                        90
                ....*....|
gi 490311494 81 QMMRQKKMDK 90
Cdd:PRK10344 82 QLMRSYTKPK 91
 
Name Accession Description Interval E-value
PRK10344 PRK10344
DNA-binding transcriptional regulator SfsB;
1-90 8.01e-60

DNA-binding transcriptional regulator SfsB;


Pssm-ID: 182394  Cd Length: 92  Bit Score: 177.08  E-value: 8.01e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490311494  1 MDKFIDWHPADIVAGLRKRGTSLAAESRRHGLSSSTLANALTRPWPKGELIIATALDTQPWVIWPSRYHDPVTHEFIDRT 80
Cdd:PRK10344  2 ESNFIDWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWVIWPSRYHDPQTHEFIDRT 81

                        90
                ....*....|
gi 490311494 81 QMMRQKKMDK 90
Cdd:PRK10344 82 QLMRSYTKPK 91
HTH_35 pfam13693
Winged helix-turn-helix DNA-binding;
6-71 3.61e-39

Winged helix-turn-helix DNA-binding;


Pssm-ID: 433408  Cd Length: 70  Bit Score: 124.27  E-value: 3.61e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490311494   6 DWHPADIVAGLRKRGTSLAAESRRHGLSSSTLANALTRPWPKGELIIATALDTQPWVIWPSRYHDP 71
Cdd:pfam13693  1 DWHPADIKAALRKRGTTLAALSRSAGLSSSTLSNALTRPWPKGERIIAEALGVPPEEIWPSRYFDD 66
SfsB COG3423
Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];
1-69 4.78e-37

Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];


Pssm-ID: 442649 [Multi-domain]  Cd Length: 69  Bit Score: 118.78  E-value: 4.78e-37
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490311494  1 MDKFIDWHPADIVAGLRKRGTSLAAESRRHGLSSSTLANALTRPWPKGELIIATALDTQPWVIWPSRYH 69
Cdd:COG3423   1 MRKKKDWHPADIKAALRKRGTSLAALAREAGLSSSTLSNALTRPWPKGERAIAEALGVPPEEIWPSRYA 69
 
Name Accession Description Interval E-value
PRK10344 PRK10344
DNA-binding transcriptional regulator SfsB;
1-90 8.01e-60

DNA-binding transcriptional regulator SfsB;


Pssm-ID: 182394  Cd Length: 92  Bit Score: 177.08  E-value: 8.01e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490311494  1 MDKFIDWHPADIVAGLRKRGTSLAAESRRHGLSSSTLANALTRPWPKGELIIATALDTQPWVIWPSRYHDPVTHEFIDRT 80
Cdd:PRK10344  2 ESNFIDWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWVIWPSRYHDPQTHEFIDRT 81

                        90
                ....*....|
gi 490311494 81 QMMRQKKMDK 90
Cdd:PRK10344 82 QLMRSYTKPK 91
HTH_35 pfam13693
Winged helix-turn-helix DNA-binding;
6-71 3.61e-39

Winged helix-turn-helix DNA-binding;


Pssm-ID: 433408  Cd Length: 70  Bit Score: 124.27  E-value: 3.61e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490311494   6 DWHPADIVAGLRKRGTSLAAESRRHGLSSSTLANALTRPWPKGELIIATALDTQPWVIWPSRYHDP 71
Cdd:pfam13693  1 DWHPADIKAALRKRGTTLAALSRSAGLSSSTLSNALTRPWPKGERIIAEALGVPPEEIWPSRYFDD 66
SfsB COG3423
Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];
1-69 4.78e-37

Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];


Pssm-ID: 442649 [Multi-domain]  Cd Length: 69  Bit Score: 118.78  E-value: 4.78e-37
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490311494  1 MDKFIDWHPADIVAGLRKRGTSLAAESRRHGLSSSTLANALTRPWPKGELIIATALDTQPWVIWPSRYH 69
Cdd:COG3423   1 MRKKKDWHPADIKAALRKRGTSLAALAREAGLSSSTLSNALTRPWPKGERAIAEALGVPPEEIWPSRYA 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH