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Conserved domains on  [gi|490311620|ref|WP_004206315|]
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MULTISPECIES: anti-adapter protein IraM [Klebsiella]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PmrD super family cl23862
Polymyxin resistance protein PmrD; PmrB forms a two-component system (TCS) with PmrA that ...
 1-115 1.42e-53

Polymyxin resistance protein PmrD; PmrB forms a two-component system (TCS) with PmrA that allows Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin G. The TCS is linked to another one via the polymyxin resistance protein PmrD. PmrD is the first protein identified to mediate the connectivity between the two TCSs. It binds to the N terminal domain of the PmrA response regulator which prevents its dephosphorylation, thereby promoting the the transcription of genes involved in polymyxin resistance.


The actual alignment was detected with superfamily member PRK09919:

Pssm-ID: 420060  Cd Length: 114  Bit Score: 163.31  E-value: 1.42e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490311620   1 MKWTILNTLICPQSGIAFSAISSLRFLKFIMWYEADVILLPGESMKLYSSRVLINDQYHSLKIYNITVYDEAQWEKLRER 80
Cdd:PRK09919   1 MKWIVIDTVISPSTGISFSAISSLRNLKLILWYQADIFLPPGSIITPVKSGVLLNDKPYPITIYNITPFNKALWSLLKSS 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 490311620  81 PSCPyHAGGERSDSCFYQSFCAIKRCPNNIPRSEP 115
Cdd:PRK09919  81 QECP-GNENKITNKCLYNFSCIIKICPYGLKRNIP 114
 
Name Accession Description Interval E-value
PRK09919 PRK09919
anti-adapter protein IraM; Provisional
 1-115 1.42e-53

anti-adapter protein IraM; Provisional


Pssm-ID: 236633  Cd Length: 114  Bit Score: 163.31  E-value: 1.42e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490311620   1 MKWTILNTLICPQSGIAFSAISSLRFLKFIMWYEADVILLPGESMKLYSSRVLINDQYHSLKIYNITVYDEAQWEKLRER 80
Cdd:PRK09919   1 MKWIVIDTVISPSTGISFSAISSLRNLKLILWYQADIFLPPGSIITPVKSGVLLNDKPYPITIYNITPFNKALWSLLKSS 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 490311620  81 PSCPyHAGGERSDSCFYQSFCAIKRCPNNIPRSEP 115
Cdd:PRK09919  81 QECP-GNENKITNKCLYNFSCIIKICPYGLKRNIP 114
PmrD pfam11183
Polymyxin resistance protein PmrD; PmrB forms a two-component system (TCS) with PmrA that ...
 1-77 2.50e-04

Polymyxin resistance protein PmrD; PmrB forms a two-component system (TCS) with PmrA that allows Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin G. The TCS is linked to another one via the polymyxin resistance protein PmrD. PmrD is the first protein identified to mediate the connectivity between the two TCSs. It binds to the N terminal domain of the PmrA response regulator which prevents its dephosphorylation, thereby promoting the the transcription of genes involved in polymyxin resistance.


Pssm-ID: 402658  Cd Length: 81  Bit Score: 37.12  E-value: 2.50e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490311620    1 MKWTILNTLICPQSGIAFSAISSLRFLKFIMWYEADVILLPGESMK-LYSSRVLIN-DQYHSLKIYNITVYDEAQWEKL 77
Cdd:pfam11183   1 MEWLVKKSLNNKQTGLHVLVLDAGGALKMIAEVDSDFKLQTGDTLSpLQDAGYCLNrEKAQTLKIHRAMPYSQDRWQRA 79
 
Name Accession Description Interval E-value
PRK09919 PRK09919
anti-adapter protein IraM; Provisional
 1-115 1.42e-53

anti-adapter protein IraM; Provisional


Pssm-ID: 236633  Cd Length: 114  Bit Score: 163.31  E-value: 1.42e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490311620   1 MKWTILNTLICPQSGIAFSAISSLRFLKFIMWYEADVILLPGESMKLYSSRVLINDQYHSLKIYNITVYDEAQWEKLRER 80
Cdd:PRK09919   1 MKWIVIDTVISPSTGISFSAISSLRNLKLILWYQADIFLPPGSIITPVKSGVLLNDKPYPITIYNITPFNKALWSLLKSS 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 490311620  81 PSCPyHAGGERSDSCFYQSFCAIKRCPNNIPRSEP 115
Cdd:PRK09919  81 QECP-GNENKITNKCLYNFSCIIKICPYGLKRNIP 114
PmrD pfam11183
Polymyxin resistance protein PmrD; PmrB forms a two-component system (TCS) with PmrA that ...
 1-77 2.50e-04

Polymyxin resistance protein PmrD; PmrB forms a two-component system (TCS) with PmrA that allows Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin G. The TCS is linked to another one via the polymyxin resistance protein PmrD. PmrD is the first protein identified to mediate the connectivity between the two TCSs. It binds to the N terminal domain of the PmrA response regulator which prevents its dephosphorylation, thereby promoting the the transcription of genes involved in polymyxin resistance.


Pssm-ID: 402658  Cd Length: 81  Bit Score: 37.12  E-value: 2.50e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490311620    1 MKWTILNTLICPQSGIAFSAISSLRFLKFIMWYEADVILLPGESMK-LYSSRVLIN-DQYHSLKIYNITVYDEAQWEKL 77
Cdd:pfam11183   1 MEWLVKKSLNNKQTGLHVLVLDAGGALKMIAEVDSDFKLQTGDTLSpLQDAGYCLNrEKAQTLKIHRAMPYSQDRWQRA 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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