|
Name |
Accession |
Description |
Interval |
E-value |
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
1-387 |
5.77e-159 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 452.20 E-value: 5.77e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 1 MKERTQLLYSGEMNLPGHiHPDAPAIFPATAYAMQDTQHYFAVSSG-NGEYQYNRTANPNRDSLSAAISLMEDGEVSAVM 79
Cdd:COG0626 1 MGPATRAVHAGRDPDPQT-GAVSPPIYLTSTFVFPSAEALAARFAGeEGGYIYSRYGNPTRRALEEALAALEGGEAALAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 80 ASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKV 159
Cdd:COG0626 80 ASGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 160 VDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCS-QVLMQKIELKARLLGGCS 238
Cdd:COG0626 160 VDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRdEELAERLRFLQNALGAVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 239 DPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLFlQGCGPMLSFRVADDQTKVD 318
Cdd:COG0626 240 SPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQM-SGFGGMLSFELKGGREAAR 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490362537 319 AFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:COG0626 319 RFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALA 387
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
23-387 |
2.71e-141 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 406.59 E-value: 2.71e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 23 APAIFPATAYAMQDTQHYFAVSSG-NGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLV 101
Cdd:cd00614 4 APPIYQTSTFVFPSPAEAADLFALrEGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGDHVV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 102 VNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNT 181
Cdd:cd00614 84 ASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVVDNT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 182 FSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQV-LMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQ 260
Cdd:cd00614 164 FATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEaLIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRMERH 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 261 MENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLFLqGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSL 340
Cdd:cd00614 244 SENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMS-GYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVESLV 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 490362537 341 AHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:cd00614 323 EHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
5-387 |
5.47e-128 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 373.11 E-value: 5.47e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 5 TQLLYSGEMNLPGHiHPDAPAIFPATAYAmQDTQhyfavsSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMA 84
Cdd:pfam01053 2 TLAVHAGQRPDPQT-GAVSVPIYLTSTYV-FDFA------GEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 85 AISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDA 164
Cdd:pfam01053 74 AITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 165 IAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCS-QVLMQKIELKARLLGGCSDPYTA 243
Cdd:pfam01053 154 IAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNgEELGKELYFLQNATGAVLSPFDA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 244 WLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSlFLQGCGPMLSFRVADDQTKVDAFIRR 323
Cdd:pfam01053 234 WLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKR-QMKGFGGMLSFELKGGLEAAKKFLDN 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490362537 324 LNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:pfam01053 313 LKLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
23-387 |
1.22e-104 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 315.05 E-value: 1.22e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 23 APAIFPATAYAMQDTQH---YFAVS-SGNgeyQYNRTANPNRDSLSAAISLMEDGeVSAV-MASGMAAISATLLSLLRQG 97
Cdd:COG2873 27 AVPIYQTTSYVFDDAEHaadLFALKePGN---IYTRIMNPTTDVLEKRIAALEGG-VAALaTASGQAAITLAILNLAEAG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 98 DHLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLV 177
Cdd:COG2873 103 DHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPALDVLDIEAIAEIAHEHGVPLI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 178 VDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVtcsqvlmqkIE----------------------------- 228
Cdd:COG2873 183 VDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVI---------VDggnfdwaangkfpeltepdpsyhglvyte 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 229 --------LKARL-----LGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAK 295
Cdd:COG2873 254 afgnaafiTKARVqllrdLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGLPSHPYHELAQ 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 296 SLFLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAA 375
Cdd:COG2873 334 KYLPKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTPDLIRLSVGIEDI 413
|
410
....*....|..
gi 490362537 376 EDLIADITQALD 387
Cdd:COG2873 414 DDIIADLDQALA 425
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
24-387 |
6.48e-101 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 304.26 E-value: 6.48e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 24 PAIFPATAYAmQDtqhyfAVSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVN 103
Cdd:PRK07811 33 PPIYASSTFA-QD-----GVGGLRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATDCLLRAVLRPGDHIVIP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 104 EAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFS 183
Cdd:PRK07811 107 NDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIAALAELAHDAGAKVVVDNTFA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 184 TPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCS-QVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQME 262
Cdd:PRK07811 187 SPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNdEELDEAFAFLQNGAGAVPGPFDAYLTLRGLKTLAVRMDRHSE 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 263 NAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAH 342
Cdd:PRK07811 267 NAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQ-MRGFGGMVSVRLAGGEEAARDFCARTKVFTLAESLGGVESLIEH 345
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 490362537 343 PATAFRTEFTPQQLidfGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK07811 346 PSAMTHASTAGSQL---EVPDDLVRLSVGIEDVADLLADLEQALG 387
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
17-386 |
5.58e-97 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 294.28 E-value: 5.58e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 17 GHIHPDA-----PAIFPATAYAMQDTqhyfAVSSGNG-EYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATL 90
Cdd:PRK08574 10 GYRGSDPygslqPPIYLTALFRQEGE----AYPSDRGfDLKYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 91 LSLLRQGDHLVVNEAIYGETIELIDLiLVPLGVTVTYAdFLSPESVQAAIR-PETVMLYTEIISNPLIKVVDIDAIAGIS 169
Cdd:PRK08574 86 FSLLKAGDRVVLPMEAYGTTLRLLKS-LEKFGVKVVLA-YPSTEDIIEAIKeGRTKLVFIETMTNPTLKVIDVPEVAKAA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 170 RANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTC-SQVLMQKIELKARLLGGCSDPYTAWLCLR 248
Cdd:PRK08574 164 KELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAwSGEFLEELWEWRRRLGTIMQPFEAYLVLR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 249 SIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLFLQGC-GPMLSFRVADDQTKVDAFIRRLNLI 327
Cdd:PRK08574 244 GLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKDLyGGVVSFRVKGGRDAVLKFLRSLKLI 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490362537 328 TYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQAL 386
Cdd:PRK08574 324 KPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQAL 382
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
50-387 |
3.98e-95 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 289.59 E-value: 3.98e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 50 YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYAD 129
Cdd:PRK08133 53 NIYSRFTNPTVTMFQERLAALEGAEACVATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVD 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 130 FLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGH 209
Cdd:PRK08133 133 LTDLDAWRAAVRPNTKLFFLETPSNPLTELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQ 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 210 SDLTAGSVTCSQVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHP 289
Cdd:PRK08133 213 GRVLGGAVVGSKELMEEVFGFLRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHP 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 290 QHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRIS 369
Cdd:PRK08133 293 QHELAKRQ-QKGGGAIVSFEVKGGREAAWRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVA 371
|
330
....*....|....*...
gi 490362537 370 AGCEAAEDLIADITQALD 387
Cdd:PRK08133 372 VGLEDVADIKADLARGLA 389
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
5-387 |
1.18e-94 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 288.56 E-value: 1.18e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 5 TQLLYSGEMNLPGHIHPDAPaIFPATAYAMQDTQHYFAVSSGNGE-YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGM 83
Cdd:PRK08249 11 TKAVWAGEKEYLPYGATQVP-VVLSVAYGYDDIDEWYDVALGKKPgHIYSRNTNPTVQAFEEKVRILEGAEAATAFSTGM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 84 AAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDID 163
Cdd:PRK08249 90 AAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVDIE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 164 AIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQVLMQKIELKARLLGGCSDPYTA 243
Cdd:PRK08249 170 RLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCGSKELMEQVYHYREINGATMDPMSA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 244 WLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRR 323
Cdd:PRK08249 250 YLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQ-MRGFGGILSFVLKGGMDTVKRLLPK 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490362537 324 LNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK08249 329 LRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFA 392
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
1-387 |
2.92e-94 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 287.00 E-value: 2.92e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 1 MKERTQLLYSGemnLPGHIHPDA--PAIFPATAYamqdTQHYFAVSSGngeYQYNRTANPNRDSLSAAISLMEDGEVSAV 78
Cdd:PRK07671 1 MRAKTKLIHGG---IIGDPSTGAvsVPIYQVSTY----KQEAVGKHQG---YEYSRTGNPTRAALEELIAVLEGGHAGFA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 79 MASGMAAISATLLsLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIK 158
Cdd:PRK07671 71 FGSGMAAITAVMM-LFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 159 VVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAG-SVTCSQVLMQKIELKARLLGGC 237
Cdd:PRK07671 150 ITDIKKISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGlVVVNSPELAEDLHFVQNSTGGI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 238 SDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFRVADDQtKV 317
Cdd:PRK07671 230 LGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQ-ANGFGGMISFDVGSEE-TA 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 318 DAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK07671 308 NKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
50-387 |
1.89e-92 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 282.93 E-value: 1.89e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 50 YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYAD 129
Cdd:TIGR01328 51 YIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGMGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFIN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 130 FLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGH 209
Cdd:TIGR01328 131 MAIPEEVKAHIKDNTKIVYFETPANPTMKLIDMERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGH 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 210 SDLTAGSVTCSQVLMQKIELKAR--LLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLAS 287
Cdd:TIGR01328 211 GDVVAGLICGKAELLQQIRMVGIkdMTGSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFED 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 288 HPQHDLAKSLFLQGcGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIR 367
Cdd:TIGR01328 291 HPGHDIAAKQMRMG-GGMITFELKGGFAGAKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIR 369
|
330 340
....*....|....*....|
gi 490362537 368 ISAGCEAAEDLIADITQALD 387
Cdd:TIGR01328 370 LSVGLEDADDLIADLKQALD 389
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
5-386 |
6.36e-92 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 282.32 E-value: 6.36e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 5 TQLLYSGEMNLPGHiHPDAPAIFPATAYAMQDTQH---YFAVSS-GNgeyQYNRTANPNRDSLSAAISLMEDGEVSAVMA 80
Cdd:TIGR01326 4 TLQLHAGQEPDPTT-GSRAVPIYQTTSYVFDSTEHaaaLFGLQEpGN---IYSRLMNPTTDVLEQRIAALEGGVAALAVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 81 SGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVV 160
Cdd:TIGR01326 80 SGQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 161 DIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQVLMQKIE------------ 228
Cdd:TIGR01326 160 DIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGGKFDWNNGrfplfttpdpsy 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 229 ---------------LKARL-----LGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASH 288
Cdd:TIGR01326 240 hglvftetlgnpafiLKARVqllrdLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 289 PQHDLAKSLFLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRI 368
Cdd:TIGR01326 320 PHHALAKKYLPKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRL 399
|
410
....*....|....*...
gi 490362537 369 SAGCEAAEDLIADITQAL 386
Cdd:TIGR01326 400 SVGIENIDDIIADLEQAL 417
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
24-387 |
1.35e-91 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 280.92 E-value: 1.35e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 24 PAIFPATAYAMQDTQHYFAVSSGNGE-YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVV 102
Cdd:PRK07503 30 PPVYLTATFAFPTAEYGAECFAGEEEgHFYSRISNPTLALLEQRMASLEGGEAAVALASGMGAITATLWTLLRPGDEVIV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 103 NEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTF 182
Cdd:PRK07503 110 DQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVDIAAVAEIAHGAGAKVVVDNTY 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 183 STPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQVLMQKIELKA--RLLGGCSDPYTAWLCLRSIRTMEMRLSRQ 260
Cdd:PRK07503 190 CTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADRIRLEGlkDMTGAVMSPFDAFLLMRGLKTLALRMDRH 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 261 MENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLFLQGcGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSL 340
Cdd:PRK07503 270 CASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALP-GGMIAFELKGGIAAGRRFMNALQLFARAVSLGDAESLA 348
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 490362537 341 AHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK07503 349 QHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALD 395
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
50-387 |
9.55e-91 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 278.63 E-value: 9.55e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 50 YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYAD 129
Cdd:PRK06234 56 YIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVD 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 130 FLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRAN--GCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFG 207
Cdd:PRK06234 136 TSNLEEVRNALKANTKVVYLETPANPTLKVTDIKAISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLN 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 208 GHSDLTAGSVTCSQVLMQKIELKA--RLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGL 285
Cdd:PRK06234 216 GHGDVIAGFVVGKEEFINQVKLFGikDMTGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGL 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 286 ASHPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGL 365
Cdd:PRK06234 296 ESFEYYELAKKQ-MSLPGAMISFELKGGVEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGL 374
|
330 340
....*....|....*....|..
gi 490362537 366 IRISAGCEAAEDLIADITQALD 387
Cdd:PRK06234 375 VRLSVGLEDVDDIIADLKQALD 396
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
1-390 |
1.00e-90 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 277.87 E-value: 1.00e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 1 MKERTQLLYSGEMNLPGHIhpdAPAIFPATAYamqdtqHYfavsSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMA 80
Cdd:PRK06460 1 MKDATRTVREDIDEATGAI---TTPIYQTTAY------HY----PEGEKYRYSREANPTVLELTKKIVELENAEMGVAFS 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 81 SGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVV 160
Cdd:PRK06460 68 SGMGAISTTALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVV 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 161 DIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQVLMQKIELKARLLGGCSDP 240
Cdd:PRK06460 148 DITELSKVCKENGSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKLLNVIDQMRRTLGTSLDP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 241 YTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAF 320
Cdd:PRK06460 228 HAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRV-LKGFGGVLSFEVNGGQESALKV 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 321 IRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALDVFN 390
Cdd:PRK06460 307 MKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRALSTLY 376
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
37-387 |
2.28e-90 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 277.42 E-value: 2.28e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 37 TQHYFAVSSgNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLsLLRQGDHLVVNEAIYGETIELIDL 116
Cdd:PRK08064 34 TFHQFDFDT-FGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTAFL-LLSKGDHVLISEDVYGGTYRMITE 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 117 ILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGAD 196
Cdd:PRK08064 112 VLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGAD 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 197 IVIHSLTKFFGGHSDLTAG-SVTCSQVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDP 275
Cdd:PRK08064 192 VVLHSATKFLAGHSDVLAGlAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHP 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 276 RVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFRVADDQTkVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQ 355
Cdd:PRK08064 272 KVQNVYYPGLQTHLGFDIQQSQ-ATSAGAVLSFTLQSEEA-VRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKEE 349
|
330 340 350
....*....|....*....|....*....|..
gi 490362537 356 LIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK08064 350 RDERGITDGLLRLSVGLENVDDLIADFEQALS 381
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
25-387 |
2.66e-87 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 269.64 E-value: 2.66e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 25 AIFPATAYAMQDTQHYFAVSSGN-GEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVN 103
Cdd:PRK05939 13 PIHTSVTYGYEDARDLIDVFQGKkPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGDHLVSS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 104 EAIYGETIELIDlILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFS 183
Cdd:PRK05939 93 QFLFGNTNSLFG-TLRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 184 TPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVT---------------------CSQVLMQKIELKA-RLLGGCSDPY 241
Cdd:PRK05939 172 SPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTdtglfdwsaypnifpayrkgdPQQWGLTQIRKKGlRDMGATLSSE 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 242 TAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLFlQGCGPMLSFRVADDQTKVDaFI 321
Cdd:PRK05939 252 AAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELF-RHYGGLLSFELADGIDCFD-FL 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490362537 322 RRLNLITYLGTLGGFRTsLAHPA--TAFrTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK05939 330 NRLKLVIKATHLGDTRT-LVIPVapTIY-YEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALD 395
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
49-386 |
2.69e-86 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 266.76 E-value: 2.69e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 49 EYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISAtLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYA 128
Cdd:PRK06176 41 GYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA-VFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTII 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 129 DFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGG 208
Cdd:PRK06176 120 DTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGG 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 209 HSDLTAGSVTC-SQVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLAS 287
Cdd:PRK06176 200 HSDVVAGLVTTnNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPT 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 288 HPQHDLAKSLfLQGCGPMLSFRVADDQtKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIR 367
Cdd:PRK06176 280 HPNHELAKKQ-MRGFSGMLSFTLKNDS-EAVAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVR 357
|
330
....*....|....*....
gi 490362537 368 ISAGCEAAEDLIADITQAL 386
Cdd:PRK06176 358 LSVGIEHEQDLLEDLEQAF 376
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
23-386 |
4.54e-86 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 265.80 E-value: 4.54e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 23 APAIFPATAYAmqdtqHyfavsSGNGE---YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISaTLLSLLRQGDH 99
Cdd:PRK08247 24 NPPVYFSTAYR-----H-----EGIGEstgFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQ-LVMSLFRSGDE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 100 LVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVD 179
Cdd:PRK08247 93 LIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAKKHGLLLIVD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 180 NTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAG-SVTCSQVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLS 258
Cdd:PRK08247 173 NTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGlVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRGMKTLALRMR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 259 RQMENAQHIAEALSGDPRVAQVNYPGLashpqhdlakslflqgcGPMLSFRVAdDQTKVDAFIRRLNLITYLGTLGGFRT 338
Cdd:PRK08247 253 QHEENAKAIAAFLNEQPGVTDVLYPGR-----------------GGMLSFRLQ-DEEWVNPFLKSLKLITFAESLGGVES 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 490362537 339 SLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQAL 386
Cdd:PRK08247 315 FITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAF 362
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
23-386 |
1.04e-84 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 264.31 E-value: 1.04e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 23 APAIFPATAYAMQDTQHYFAVSS----GNgeyQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGD 98
Cdd:PRK07812 33 ALPIYQTTSYTFDDTDHAAALFGlaepGN---IYTRIMNPTQDVVEQRIAALEGGVAALLLASGQAAETFAILNLAGAGD 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 99 HLVVNEAIYGETIELIDLILVPLGVTVTY-ADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLV 177
Cdd:PRK07812 110 HIVSSPRLYGGTYNLFHYTLPKLGIEVSFvEDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLDIPGVAEVAHEAGVPLI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 178 VDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAG--------------------------SVTCSQVLMQKIELKA 231
Cdd:PRK07812 190 VDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGvivdggtfdwtqgrfpgfttpdpsyhGVVFAELGPPAYALKA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 232 RL-----LGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLFLQGCGPML 306
Cdd:PRK07812 270 RVqllrdLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPWYERAKRLAPKGTGAVL 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 307 SFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQAL 386
Cdd:PRK07812 350 SFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLAVGIEGIDDILADLEAGF 429
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
21-388 |
1.09e-84 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 262.24 E-value: 1.09e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 21 PDAPAIFPATAYamqdtqhYFAVSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVsAVMASGMAAISATLLSLLRQGDHL 100
Cdd:PRK07582 21 PVLPGPVFAAPY-------HLSPGEPTGPDTYGRASNPTWRALEAALGELEGAEA-LVFPSGMAAITAVLRALLRPGDTV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 101 VVNEAIYGETIELIDLILVPLGVTVTYADflSPESVQAAIRPETVMLyTEIISNPLIKVVDIDAIAGISRANGCLLVVDN 180
Cdd:PRK07582 93 VVPADGYYQVRALAREYLAPLGVTVREAP--TAGMAEAALAGADLVL-AETPSNPGLDVCDLAALAAAAHAAGALLVVDN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 181 TFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQV-LMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSR 259
Cdd:PRK07582 170 TTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPeLMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFAR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 260 QMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAkSLFLQGCGPMLSFRVADDQtKVDAFIRRLNLITYLGTLGGFRTS 339
Cdd:PRK07582 250 QCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVA-ARQMRRFGGLVSFELADAA-AAERFVAASRLVVAATSFGGVHTS 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 490362537 340 LAHPATafrteftpqqlidFGMH--EGLIRISAGCEAAEDLIADITQALDV 388
Cdd:PRK07582 328 ADRRAR-------------WGDAvpEGFVRLSCGIEDTDDLVADLERALDA 365
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
23-387 |
2.73e-82 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 256.69 E-value: 2.73e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 23 APAIFPATAYAMQDTQHYFAVSSGNGE-YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLV 101
Cdd:PRK06767 25 TPPLFQTSTFTFETAQQGEASFAGVDPsYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSGMAAISATLIGFLKAGDHII 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 102 VNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNT 181
Cdd:PRK06767 105 CSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLIDLKQVIRVAKRNGLLVIVDNT 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 182 FSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQVLMQKIELKARL-LGGCSDPYTAWLCLRSIRTMEMRLSRQ 260
Cdd:PRK06767 185 FCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKdIGGIMAPFDAWLLLRGLKTLAVRMDRH 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 261 MENAQHIAEALSGDPRVAQVNYpglashPQHDLAKSLFLQGcGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSL 340
Cdd:PRK06767 265 CDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRG-GGVISFSIKGGKEETQAFINDLHFITIAVSLGDTETLI 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 490362537 341 AHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK06767 338 QHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
49-386 |
9.72e-82 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 255.11 E-value: 9.72e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 49 EYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDlILVPLGV-TVTY 127
Cdd:TIGR02080 42 AYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVTTALLGPDDLLVAPHDCYGGTYRLLN-ALAKKGCfRVLF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 128 ADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFG 207
Cdd:TIGR02080 121 VDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAVGAVVVVDNTFLSPALQNPLALGADLVLHSCTKYLN 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 208 GHSDLTAGSVTCSQV-LMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLA 286
Cdd:TIGR02080 201 GHSDVIAGAVIAKDPqVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARMRLQQRNAQAIVEYLQTQPLVKKIYYPGLP 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 287 SHPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLI 366
Cdd:TIGR02080 281 DHPGHEIAARQ-QKGFGAMLSFELKGGEQTVRRFLGGLSLFTLAESLGGVESLIAHPATMTHAAMGPEARAEAGISDTLL 359
|
330 340
....*....|....*....|
gi 490362537 367 RISAGCEAAEDLIADITQAL 386
Cdd:TIGR02080 360 RLSVGLEDADDLIADLEQGL 379
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
49-386 |
4.29e-81 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 254.14 E-value: 4.29e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 49 EYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYA 128
Cdd:PRK08776 51 QYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 129 DFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGG 208
Cdd:PRK08776 131 DLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYING 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 209 HSDLTAGSVTCSQV-LMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLAS 287
Cdd:PRK08776 211 HSDVVGGAVVARDAeLHQQLVWWANALGLTGSPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLAS 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 288 HPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIR 367
Cdd:PRK08776 291 HPGHALAARQ-QKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLR 369
|
330
....*....|....*....
gi 490362537 368 ISAGCEAAEDLIADITQAL 386
Cdd:PRK08776 370 LSVGIESAEDLLIDLRAGL 388
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
20-386 |
6.38e-81 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 254.66 E-value: 6.38e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 20 HPD------APAIFPATAYAMQDTQHyfAVSSGNGE---YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATL 90
Cdd:PRK08134 19 APDpatgarAVPIHLTTSFVFRDSDH--AAALFNLEragHVYSRISNPTVAVLEERVAALEGGVGAIATASGQAALHLAI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 91 LSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISR 170
Cdd:PRK08134 97 ATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDIPTVAAIAH 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 171 ANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHS----------------------DLTA------GSVTCSQV 222
Cdd:PRK08134 177 EAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGtaiggvlvdggrfdweasgkfpELTEpyagfhGMVFAEES 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 223 LMQKIELKARL-----LGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSL 297
Cdd:PRK08134 257 TVAAFLLRARReglrdFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHPDHALAKRL 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 298 FLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAED 377
Cdd:PRK08134 337 LPRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLSIGLEDADD 416
|
....*....
gi 490362537 378 LIADITQAL 386
Cdd:PRK08134 417 LIDDLKRAL 425
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
5-386 |
2.37e-76 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 240.89 E-value: 2.37e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 5 TQLLYSGEMNLPghIHPDAPAIFPATAYAMQDtqhyfavSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMA 84
Cdd:TIGR01329 3 TLLVNTDNKNDP--YDASSMPIYQTATFKQPL-------AIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 85 AISaTLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDA 164
Cdd:TIGR01329 74 ALD-VITRLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 165 IAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGsVTC--SQVLMQKIELKARLLGGCSDPYT 242
Cdd:TIGR01329 153 ISEMAHAQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAG-VLAvkGEEIAKKVYFLQNSTGSGLAPFD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 243 AWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSlFLQGCGPMLSFRVADDQTKvDAFIR 322
Cdd:TIGR01329 232 CWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFS-QAKGAGSVLSFETGSVALS-KRLVE 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490362537 323 RLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQAL 386
Cdd:TIGR01329 310 ATKLFSITVSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAF 373
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
5-387 |
1.11e-74 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 237.35 E-value: 1.11e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 5 TQLLYSGEMNLPghihpdapaiFPATAYAMQDTQHYFAVSSGNGE---------YQYNRTANPNRDSLSAAISLMEDGEV 75
Cdd:PRK07504 13 TRLVHSGTLRSQ----------FGETSEALFLTQGFVYDTAEAAEarfkgedpgFIYSRYSNPTVDMFEKRMCALEGAED 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 76 SAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNP 155
Cdd:PRK07504 83 ARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 156 LIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQVLMQ-KIELKARLL 234
Cdd:PRK07504 163 TLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEeHLQDYFRHT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 235 GGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFRVADDQ 314
Cdd:PRK07504 243 GPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQ-MTGGSTLVAFELKGGK 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490362537 315 TKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK07504 322 EAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALK 394
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
23-386 |
3.40e-73 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 234.74 E-value: 3.40e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 23 APAIFPATAYAMQDTQH---YFAVSS-GNgeyQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGD 98
Cdd:PRK08248 28 AVPIYQTTSYGFRDSEHaanLFSLKEfGN---IYTRIMNPTTDVFEKRIAALEGGIGALAVSSGQAAITYSILNIASAGD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 99 HLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVV 178
Cdd:PRK08248 105 EIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLDIEAVAAIAHEHGIPLIV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 179 DNTFSTPFVIKPLQHGADIVIHSLTKFFGGHS-------------DLTA---------------GSVTCSQVLMQKIELK 230
Cdd:PRK08248 185 DNTFASPYLLRPIEHGADIVVHSATKFIGGHGtsiggvivdsgkfDWKGsgkfpgltepdpsyhGLVYTDAVGEAAYITK 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 231 ARL-----LGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLFLQGCGPM 305
Cdd:PRK08248 265 ARVqllrdLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSHPSYELAKKYLPKGQGAI 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 306 LSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQA 385
Cdd:PRK08248 345 LTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVRLSVGTEAIDDILDDLRQA 424
|
.
gi 490362537 386 L 386
Cdd:PRK08248 425 I 425
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
52-387 |
2.36e-72 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 232.25 E-value: 2.36e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 52 YNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVT-VTYADF 130
Cdd:PRK07049 77 YSRFNHPNSEIVEDRLAVYEGAESAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGaVGFADG 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 131 LSPESVQAAI-----RPETVMLYTEIISNPLIKVVDIDAIAGISRANG------CLLVVDNTFSTPFVIKPLQHGADIVI 199
Cdd:PRK07049 157 LSEAAIGAAAeaaaaKGRVSLILIETPANPTNSLVDVAAVRRVADAIEarqghrPIIACDNTLLGPVFQKPLEHGADLSV 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 200 HSLTKFFGGHSDLTAGSVTCSQVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQ 279
Cdd:PRK07049 237 YSLTKYVGGHSDLVAGAVLGRKALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEK 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 280 VNYPGLasHPQHDLAKSLFLQGC---GPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQL 356
Cdd:PRK07049 317 LHYLPF--LDPDSAYGAVYKRQCtgaGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVR 394
|
330 340 350
....*....|....*....|....*....|.
gi 490362537 357 IDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK07049 395 ERIGVLESTIRLSIGIEHPDDLIADLAQALD 425
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
47-389 |
7.81e-71 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 229.53 E-value: 7.81e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 47 NGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISAtLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVT 126
Cdd:PLN02509 122 NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSA-VTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVK 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 127 YADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFF 206
Cdd:PLN02509 201 RVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFI 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 207 GGHSDLTAGsvtcsqVLMQKIELKARLL-------GGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQ 279
Cdd:PLN02509 281 AGHSDVMAG------VLAVKGEKLAKEVyflqnseGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKK 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 280 VNYPGLASHPQHDLAKSLfLQGCGPMLSFRVAD--------DQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEf 351
Cdd:PLN02509 355 VYYAGLPDHPGHHLHFSQ-AKGAGSVFSFITGSvalskhlvETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREAR- 432
|
330 340 350
....*....|....*....|....*....|....*...
gi 490362537 352 tpqqlidfGMHEGLIRISAGCEAAEDLIADITQALDVF 389
Cdd:PLN02509 433 --------GLTEDLVRISAGIEDVDDLISDLDIAFRTG 462
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
23-386 |
5.46e-70 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 226.13 E-value: 5.46e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 23 APAIFPATAYAMQDTQH---YFAVSS-GNgeyQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGD 98
Cdd:PRK05994 27 ATPIYQTTSFVFNDADHaasLFGLQAfGN---IYTRITNPTNAVLEERVAALEGGTAALAVASGHAAQFLVFHTLLQPGD 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 99 HLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVV 178
Cdd:PRK05994 104 EFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTDIAAIAEVAHRAGLPLIV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 179 DNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSD------LTAGSVTCSQ-----------------VLMQKIE------- 228
Cdd:PRK05994 184 DNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNsmggiiVDGGTFDWSKsgkypmlseprpeyhglVLHETFGnfafaia 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 229 ---LKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLFLQGCGPM 305
Cdd:PRK05994 264 arvLGLRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDDPYHALAQKYSPKGAGAV 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 306 LSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQA 385
Cdd:PRK05994 344 FTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLSIGIEDVDDIIADLEQA 423
|
.
gi 490362537 386 L 386
Cdd:PRK05994 424 L 424
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
15-388 |
4.55e-67 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 217.26 E-value: 4.55e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 15 LPGHIHPDA-----PAIFPATAYAMQDTQHYFAVSSGNG-EYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISA 88
Cdd:PRK05968 14 ITAHDEGNAfdavvPPIFQTSLFTFDSYDEMEDVYAGEKvRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 89 TLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIrPETVMLYTEIISNPLIKVVDIDAIAGI 168
Cdd:PRK05968 94 TVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDVAALAAL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 169 SRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQVLMQKIELKAR-LLGGCSDPYTAWLCL 247
Cdd:PRK05968 173 AKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARINAEAYpYLGAKLSPFEAWLLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 248 RSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAkslflqGCGPMLSFRVADDqTKVDAFIRRLNLI 327
Cdd:PRK05968 253 RGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGLS------GTSGLFSFIFREG-IDVRAFADALKLF 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490362537 328 TyLGTLGGFRTSLAHPA-TAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALDV 388
Cdd:PRK05968 326 R-LGVSWGGHESLVVPAeVVLQQKAQPNSAARFGVSPRSVRLHVGLEGTEALWADLEQALAA 386
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
10-387 |
8.93e-67 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 218.20 E-value: 8.93e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 10 SGEMNLPghihpdapaIFPATAYAMQDTQH---YFAVSSGNGeyQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAI 86
Cdd:PRK05613 29 TSARNLP---------IYQTTSYVFDSAEHakqRFALEDLGP--IYSRLTNPTVEALENRIASLEGGVHAVAFASGQAAE 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 87 SATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYA-DFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAI 165
Cdd:PRK05613 98 TAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVLDIPAV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 166 AGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQVLMQKIE----------------- 228
Cdd:PRK05613 178 AEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKFDWTVErdgkpvfpyfvtpdpay 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 229 --------------LKAR--LL---GGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHP 289
Cdd:PRK05613 258 hglkyadlgapafgLKARagLLrdtGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGLKDSP 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 290 QHDLAKSLFLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRIS 369
Cdd:PRK05613 338 WYATKEKLGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQATVRLS 417
|
410
....*....|....*...
gi 490362537 370 AGCEAAEDLIADITQALD 387
Cdd:PRK05613 418 VGIEDIDDIIADLEGGFA 435
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
5-387 |
5.61e-66 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 214.38 E-value: 5.61e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 5 TQLLYSGEMNLPGHIHPDAPaIFPATAYAMQDTQ-HYFAVSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGM 83
Cdd:PRK06434 11 TRAVQSGELRDPRFGNVTTP-IFETSTFVYPNSEkEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 84 AAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVtyaDFLSPESVQAA-IRPETV-MLYTEIISNPLIKVVD 161
Cdd:PRK06434 90 GAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHV---DYIDTDRLNSLdFDPSNYdLIYAESITNPTLKVPD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 162 IDAIAgiSRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSV-TCSQVLMQKIELKARLLGGCSDP 240
Cdd:PRK06434 167 IKNVS--SFCHENDVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAgTNNKSIFNNLVERRKTLGSNPDP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 241 YTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLashpqhDLAKSLfLQGCGPMLSFRVADDQtKVDAF 320
Cdd:PRK06434 245 IQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKV-LRGFGGMLSFELRSME-DVHKF 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490362537 321 IRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK06434 317 IRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALS 383
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
23-387 |
7.14e-65 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 212.84 E-value: 7.14e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 23 APAIFPATAYAMQDTQH---YFAVS-SGNgeyQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGD 98
Cdd:PRK06084 22 AVPIYQTTSYAFDDTQHgadLFDLKvPGN---IYTRIMNPTNDVLEQRVAALEGGVGALAVASGMAAITYAIQTIAEAGD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 99 HLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVV 178
Cdd:PRK06084 99 NIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQALADAAHRHGVPLIV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 179 DNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQVL-----MQKIEL------------------KARLLG 235
Cdd:PRK06084 179 DNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFpwaehKERFALlntpdpsyhgvtyteafgPAAFIG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 236 GCS-----------DPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLFLQGCGP 304
Cdd:PRK06084 259 RCRvvplrnmgaalSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDHPEHELARRYMGGKPAS 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 305 MLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQ 384
Cdd:PRK06084 339 ILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVRLSIGIEHIDDIIADLAQ 418
|
...
gi 490362537 385 ALD 387
Cdd:PRK06084 419 ALD 421
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
15-386 |
1.15e-64 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 211.52 E-value: 1.15e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 15 LPGHIHPDAPAI--------FPATAYAMQDTQHYF------AVSSGNGE---YQYNRTANPNRDSLSAAISLMEDGEVSA 77
Cdd:PRK07810 10 LPDGVSQATIGVrggllrsgFEETAEALYLTSGYVyesaaaAEAAFTGEldrFVYSRYGNPTVSMFEERLRLIEGAEACF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 78 VMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLI 157
Cdd:PRK07810 90 ATASGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 158 KVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCS--------QVLMqkiel 229
Cdd:PRK07810 170 SLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDreyidgpvQKLM----- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 230 kaRLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFR 309
Cdd:PRK07810 245 --RHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQ-MSGGGTVVTFE 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 310 VA--DDQTKVDAF--IRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQA 385
Cdd:PRK07810 322 LDapEDAAKKRAFevLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRA 401
|
.
gi 490362537 386 L 386
Cdd:PRK07810 402 L 402
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
50-386 |
2.87e-64 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 210.14 E-value: 2.87e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 50 YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYAD 129
Cdd:PRK08045 44 HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVD 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 130 FLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGH 209
Cdd:PRK08045 124 QGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGH 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 210 SDLTAGSVTCSQV-LMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASH 288
Cdd:PRK08045 204 SDVVAGVVIAKDPdVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPEN 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 289 PQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRI 368
Cdd:PRK08045 284 QGHEIAARQ-QKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRI 362
|
330
....*....|....*...
gi 490362537 369 SAGCEAAEDLIADITQAL 386
Cdd:PRK08045 363 STGIEDGEDLIADLENGF 380
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
49-385 |
7.73e-64 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 208.98 E-value: 7.73e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 49 EYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYA 128
Cdd:PRK08861 44 KYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFV 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 129 DFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGG 208
Cdd:PRK08861 124 DQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYING 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 209 HSDLTAGSVTC-SQVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLAS 287
Cdd:PRK08861 204 HSDVIGGVLITkTKEHAEELAWWGNCIGATGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPE 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 288 HPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIR 367
Cdd:PRK08861 284 HPGHEIAKKQ-QSGFGSMLSFEFAGSFEQLKVFVKALALFSLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLR 362
|
330
....*....|....*...
gi 490362537 368 ISAGCEAAEDLIADITQA 385
Cdd:PRK08861 363 LSVGLEDAQDLIADLDQA 380
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
47-387 |
2.17e-62 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 204.73 E-value: 2.17e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 47 NGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVT 126
Cdd:TIGR01324 39 KGELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVTNSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDIT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 127 YADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFF 206
Cdd:TIGR01324 119 YYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAKAARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 207 GGHSDLTAGSVTCSQVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLA 286
Cdd:TIGR01324 199 VGHSDIMIGTVVANARTWDQLREHSYLMGQMVDADDAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALP 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 287 SHPQHDLAKSLFLQGCGpMLSFRVAD-DQTKVDAFIRRLNLITYLGTLGGFRtSLAHPAtafRTEFTPQQLIDFGMHEGL 365
Cdd:TIGR01324 279 SCPGHEFWKRDFSGSSG-LFSFVLQRlTQKQVHAFLDHLQLFGLGYSWGGYE-SLALCN---QPELGHRPNIKRNLEGPL 353
|
330 340
....*....|....*....|..
gi 490362537 366 IRISAGCEAAEDLIADITQALD 387
Cdd:TIGR01324 354 IRVHIGLENVDDLKADLKAGFE 375
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
42-386 |
1.37e-60 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 200.81 E-value: 1.37e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 42 AVSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPL 121
Cdd:PRK05967 48 TMATRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 122 GVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHS 201
Cdd:PRK05967 128 GVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHA 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 202 LTKFFGGHSDLTAGSVTCSQVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVN 281
Cdd:PRK05967 208 ATKYPSGHSDILLGTVSANEKCWPQLLEAHGTLGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 282 YPGLASHPQHDLAKSLFlQGCGPMLSFRVADD----QTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTeftpqqlI 357
Cdd:PRK05967 288 HPALPSFPGHEIWKRDF-SGASGIFSFVLAAGpekgKAKAHAFLDALEIFGLGYSWGGYESLALHVKLGDRT-------V 359
|
330 340 350
....*....|....*....|....*....|
gi 490362537 358 DFGMHEG-LIRISAGCEAAEDLIADITQAL 386
Cdd:PRK05967 360 AKAPYAGpVIRLQIGLEDVPDLKADLERGF 389
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
47-371 |
1.21e-58 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 196.14 E-value: 1.21e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 47 NGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILvP--LGVT 124
Cdd:PLN02242 65 RDFYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFL-PrkCNIT 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 125 VTYADFLSPESVQAAIRP-ETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFsTPFVIKPLQHGADIVIHSLT 203
Cdd:PLN02242 144 TTFVDITDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTF-APMVLSPARLGADVVVHSIS 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 204 KFFGGHSDLTAGSVTCSQVL---MQKIELKA-RLLGGCSDPYTAW-LCLR----SIRtMEMRLSRQMENAQHIAEaLSgd 274
Cdd:PLN02242 223 KFISGGADIIAGAVCGPAELvnsMMDLHHGAlMLLGPTMNPKVAFeLSERlphlSLR-MKEHCRRAMEYAKRMKE-LG-- 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 275 prvAQVNYPGLASHPQHDLAKSLFLQ--GCGPMLSFRVaDDQTKVDAFIRRLNLITYLG----TLGGFRTSLAHPATAFR 348
Cdd:PLN02242 299 ---LKVIYPGLEDHPQHALLKSMANKgyGFGGLLCLDM-DTEERANRLMRYLQNSTQFGfmavSLGYYETLMSCSGSSTS 374
|
330 340
....*....|....*....|...
gi 490362537 349 TEFTPQQLIDFGMHEGLIRISAG 371
Cdd:PLN02242 375 SELDPEEKAAAGISPGLVRMSVG 397
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
38-387 |
2.13e-57 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 191.57 E-value: 2.13e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 38 QH-YFAVSSGngeYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAIsATLLSLLRQGDHLVVNEAIYGETIELIDL 116
Cdd:PRK07269 36 QHpEFGQSTG---FDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAI-VLAFSVFPVGSKVVAVRDLYGGSFRWFNQ 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 117 ILVPLGVTVTYADflSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGAD 196
Cdd:PRK07269 112 QEKEGRFHFTYAN--TEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGAD 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 197 IVIHSLTKFFGGHSDLTAGSV-TCSQVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDP 275
Cdd:PRK07269 190 IVLHSATKYLSGHNDVLAGVVvTNDLELYEKLFYNLNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSP 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 276 RVAQVNYPGLashpqhdlakslflqgcGPMLSFRVAdDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQ 355
Cdd:PRK07269 270 AVKEVLYTGK-----------------GGMISFKVA-DETRIPHILNSLKVFTFAESLGGVESLITYPTTQTHADIPAEV 331
|
330 340 350
....*....|....*....|....*....|..
gi 490362537 356 LIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK07269 332 RHSYGLTDDLLRLSIGIEDARDLIADLKQALE 363
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
24-390 |
6.35e-56 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 188.40 E-value: 6.35e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 24 PAIFPATAY---AMQDTQHYfAVSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHL 100
Cdd:PRK09028 25 PPVFRASTVvfdTVAEMRHA-AKNRANGEMFYGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISNALLSFLKAGDHL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 101 VVNEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDN 180
Cdd:PRK09028 104 LMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDN 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 181 TFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQ 260
Cdd:PRK09028 184 TWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKHWDQLREHSYLMGQCTSPDDVYLAMRGLRTLGVRLAQH 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 261 MENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLFlQGCGPMLSFRVADDQTK-VDAFIRRLNLITYLGTLGGFRT- 338
Cdd:PRK09028 264 EKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDF-SGSNGLFSFVLKQGDPKaVTALVEGMQHFKMGFSWGGFESl 342
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 490362537 339 SLAHPA-TAFRTEFTPqqliDFgmhEG-LIRISAGCEAAEDLIADITQALDVFN 390
Cdd:PRK09028 343 ILGVFGiNKLRTATNW----DF---SKpLIRLHIGLEDVDDLIADLEAGFERYN 389
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
50-386 |
3.50e-52 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 178.76 E-value: 3.50e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 50 YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTVTYAD 129
Cdd:PRK07050 57 WRYGLHATPTSLALAQRLAEIEGGRHALLQPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYD 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 130 FLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGH 209
Cdd:PRK07050 137 PLIGAGIADLIQPNTRLIWLEAPGSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 210 SDLTAGSV-TCSQVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASH 288
Cdd:PRK07050 217 SDVLMGATiTADAELHAKLKLARMRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDC 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 289 PQHDLAKSLFlQGCGPMLS--FRVADDQTKVDAFIRRLNLITyLGTLGGFRTSLA--HPATAFRTEFTPqqlidfgmHEG 364
Cdd:PRK07050 297 PGHAFWMRDF-TGAGGLFSvvFDERYSPAQVDAFVEALELFA-IGWSWGGACSLAmpYDVASMRTAKWP--------HRG 366
|
330 340
....*....|....*....|...
gi 490362537 365 -LIRISAGCEAAEDLIADITQAL 386
Cdd:PRK07050 367 tLVRLYIGLEDEADLIADLEQAL 389
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
16-386 |
2.40e-48 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 169.46 E-value: 2.40e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 16 PGHIHPDAPAIFPATAYAMQDTQHYFAVSSGNGE-YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLL 94
Cdd:PRK06702 18 PKNGEPRVLPLYQSTTYKYDTSDDLAALFNLEAEgYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLAVLNIC 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 95 RQGDHLVVNEAIYGETIELIDLILVPLGVTVTYAD-FLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISRANG 173
Cdd:PRK06702 98 SSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNpNLTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 174 CLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSV---------------------------------TCS 220
Cdd:PRK06702 178 VPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVidggnfdwtngkypelvepdpsyhgvsyvqnfgAAA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 221 QVLMQKIELkARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYPGLASHPQHDLAKSLFLQ 300
Cdd:PRK06702 258 YIVKARVQL-LRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYLKK 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 301 GCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIA 380
Cdd:PRK06702 337 GASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIEDVSDIIA 416
|
....*.
gi 490362537 381 DITQAL 386
Cdd:PRK06702 417 DLEAAL 422
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
46-383 |
1.20e-44 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 158.71 E-value: 1.20e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 46 GNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVTV 125
Cdd:PRK08114 50 ANGELFYGRRGTLTHFSLQEAMCELEGGAGCALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTT 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 126 TYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIAGISR--ANGCLLVVDNTFSTPFVIKPLQHGADIVIHSLT 203
Cdd:PRK08114 130 TWFDPLIGADIAKLIQPNTKVVFLESPGSITMEVHDVPAIVAAVRsvNPDAVIMIDNTWAAGVLFKALDFGIDISIQAGT 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 204 KFFGGHSDLTAGSVTCSQVLMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRLSRQMENAQHIAEALSGDPRVAQVNYP 283
Cdd:PRK08114 210 KYLVGHSDAMIGTAVANARCWEQLRENSYLMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHP 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 284 GLASHPQHDLAKSLFlQGCGPMLSF----RVADDQtkVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDF 359
Cdd:PRK08114 290 ALPGCKGHEFWKRDF-TGSSGLFSFvlkkKLTDEQ--LANYLDNFSLFSMAYSWGGFESLILANQPEEIAAIRPAGEVDF 366
|
330 340
....*....|....*....|....*
gi 490362537 360 gmhEG-LIRISAGCEAAEDLIADIT 383
Cdd:PRK08114 367 ---TGtLIRLHIGLEDVDDLIADLA 388
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
78-208 |
3.50e-09 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 55.47 E-value: 3.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 78 VMASGMAAISATLLSLLRQGDHLVVN----EAIYGETIELIDLILVPLGVTVTYADFLSP-ESVQAAIRPETVMLYTEII 152
Cdd:cd01494 22 FVPSGTGANEAALLALLGPGDEVIVDanghGSRYWVAAELAGAKPVPVPVDDAGYGGLDVaILEELKAKPNVALIVITPN 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 153 SNPLIKVVDIDAIAGISRANGCLLVVDNTFSTPFVIKPLQH----GADIVIHSLTKFFGG 208
Cdd:cd01494 102 TTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPGVLipegGADVVTFSLHKNLGG 161
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
28-273 |
1.07e-07 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 53.11 E-value: 1.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 28 PATAYAMQDTQHYFAVSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSA----VMASGMAAISATLLSLLRQGDHLVVN 103
Cdd:cd00609 10 FPPPPEVLEALAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPPeeivVTNGAQEALSLLLRALLNPGDEVLVP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 104 E---AIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYteIIS--NPLIKVVD---IDAIAGISRANGCL 175
Cdd:cd00609 90 DptyPGYEAAARLAGAEVVPVPLDEEGGFLLDLELLEAAKTPKTKLLY--LNNpnNPTGAVLSeeeLEELAELAKKHGIL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 176 LVVDN-----TFSTPFVIKPLQHGAD---IVIHSLTKFFgGHSDLTAGSVTCS-QVLMQKIELKARLLGGCSDPYTAWLC 246
Cdd:cd00609 168 IISDEayaelVYDGEPPPALALLDAYervIVLRSFSKTF-GLPGLRIGYLIAPpEELLERLKKLLPYTTSGPSTLSQAAA 246
|
250 260 270
....*....|....*....|....*....|.
gi 490362537 247 LRSIRT----MEMRLSRQMENAQHIAEALSG 273
Cdd:cd00609 247 AAALDDgeehLEELRERYRRRRDALLEALKE 277
|
|
| YnbB |
COG4100 |
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ... |
33-208 |
1.02e-06 |
|
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 443276 Cd Length: 409 Bit Score: 50.49 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 33 AMQDTQ---HYFAVSSGngeYQYNRTAnpnRDSLS---AAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVvneAI 106
Cdd:COG4100 35 AFQKNRvsdSHFAGTTG---YGYDDIG---RDTLErvyADVFGAEDALVRPQIVSGTHAIALALFGVLRPGDELL---SI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 107 YGE---TIE------------LIDlilvpLGVTVTYADFLS-----PESVQAAIRPETVMLYteiI-------SNPLIKV 159
Cdd:COG4100 106 TGKpydTLEevigirgegqgsLKE-----FGISYRQVPLTEdgkidLEAIKKAINEKTKMVL---IqrsrgysWRPSLTI 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 490362537 160 VDI-DAIAGISRAN-GCLLVVDNTFSTpFV--IKPLQHGADIVIHSLTKFFGG 208
Cdd:COG4100 178 EEIgEIIKFVKSINpDVICFVDNCYGE-FVetREPTEVGADLMAGSLIKNPGG 229
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
74-297 |
2.51e-04 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 42.68 E-value: 2.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 74 EVSAVMASGMAAISATLLSLLRQGDHLVV----NEAIYGETIELIDLILVPLGVTVTYADFLSPESVQAAIRPETVMLYT 149
Cdd:pfam00155 63 EAAVVFGSGAGANIEALIFLLANPGDAILvpapTYASYIRIARLAGGEVVRYPLYDSNDFHLDFDALEAALKEKPKVVLH 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 150 EIISNPLIKVVDID---AIAGISRANGCLLVVDNTFSTpFVIKPLQHGA----------DIVIHSLTKFFG--GhsdLTA 214
Cdd:pfam00155 143 TSPHNPTGTVATLEeleKLLDLAKEHNILLLVDEAYAG-FVFGSPDAVAtrallaegpnLLVVGSFSKAFGlaG---WRV 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 215 GSVTCSQVLMQKieLKARLLGGCSDPYTAWLCLRSIRT-------MEMRLSRQMENAQHIAEALS------GDPRVAQVN 281
Cdd:pfam00155 219 GYILGNAAVISQ--LRKLARPFYSSTHLQAAAAAALSDpllvaseLEEMRQRIKERRDYLRDGLQaaglsvLPSQAGFFL 296
|
250
....*....|....*.
gi 490362537 282 YPGLASHPQHDLAKSL 297
Cdd:pfam00155 297 LTGLDPETAKELAQVL 312
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
72-179 |
3.89e-04 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 42.33 E-value: 3.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 72 DGEVsAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLI--------LVPLGVTVTyadfLSPESVQAAIRPE 143
Cdd:PRK07777 85 DTEV-LVTVGATEAIAAAVLGLVEPGDEVLLIEPYYDSYAAVIAMAgahrvpvpLVPDGRGFA----LDLDALRAAVTPR 159
|
90 100 110
....*....|....*....|....*....|....*....
gi 490362537 144 TVMLYTEIISNPLIKVV---DIDAIAGISRANGCLLVVD 179
Cdd:PRK07777 160 TRALIVNSPHNPTGTVLtaaELAAIAELAVEHDLLVITD 198
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
70-227 |
2.03e-03 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 39.91 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 70 MEDGEVSAVMASGmAAISATLLSLLRQGDH---LVVNEAIYGETIELIDLILVPLG---VTVTYADF--LSPESVQAAIR 141
Cdd:cd00613 79 MDVANASLQDEAT-AAAEAAGLAAIRAYHKrnkVLVPDSAHPTNPAVARTRGEPLGievVEVPSDEGgtVDLEALKEEVS 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 142 PETVMLyteIISNP--LIKVVD-IDAIAGISRANGCLLVVD-NTFSTPFVIKPLQHGADIVIHSLTKFF------GGHsd 211
Cdd:cd00613 158 EEVAAL---MVQYPntLGVFEDlIKEIADIAHSAGALVYVDgDNLNLTGLKPPGEYGADIVVGNLQKTGvphgggGPG-- 232
|
170
....*....|....*.
gi 490362537 212 ltAGSVTCSQVLMQKI 227
Cdd:cd00613 233 --AGFFAVKKELVRFL 246
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
85-209 |
8.65e-03 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 38.00 E-value: 8.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490362537 85 AISATLLSLLRQ---GDHLVVNEAIYGETIELIDLILVPLGVTVTYADF-----LSPESVQAAIRPETVMLYTEIISNPL 156
Cdd:pfam00266 73 AINLVALSLGRSlkpGDEIVITEMEHHANLVPWQELAKRTGARVRVLPLdedglLDLDELEKLITPKTKLVAITHVSNVT 152
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 490362537 157 IKVVDIDAIAGISRANGCLLVVDNTFSTP-FVIKPLQHGADIVihsltkFFGGH 209
Cdd:pfam00266 153 GTIQPVPEIGKLAHQYGALVLVDAAQAIGhRPIDVQKLGVDFL------AFSGH 200
|
|
| |
