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Conserved domains on  [gi|490364537|ref|WP_004244214|]
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MULTISPECIES: transcriptional repressor AgaR [Proteus]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AgaR NF040755
transcriptional repressor AgaR;
1-254 5.03e-173

transcriptional repressor AgaR;


:

Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 476.76  E-value: 5.03e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   1 MKAAVERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAAIPNTGFI--AELSIHEKRGQNAG 78
Cdd:NF040755   1 MKGTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALINDGFIpgAEPSVEDKSRLNTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  79 IKTLIGKAAATLIKDGDTVILDSGTTTREIATHLKSRENVVVMTNGLDVAMELANTTGVEVLMTGGVLRKSALSFSGSQA 158
Cdd:NF040755  81 VKRLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537 159 ENSLRNYRFDKVFLGVDGFDLRVGITTHNEQEASLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVTDSGIPD 238
Cdd:NF040755 161 EQSLQNYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPE 240

                        250
                 ....*....|....*.
gi 490364537 239 EYVQELKDHKIDVIIV 254
Cdd:NF040755 241 EYLQGLRKLGVEVILV 256
 
Name Accession Description Interval E-value
AgaR NF040755
transcriptional repressor AgaR;
1-254 5.03e-173

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 476.76  E-value: 5.03e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   1 MKAAVERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAAIPNTGFI--AELSIHEKRGQNAG 78
Cdd:NF040755   1 MKGTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALINDGFIpgAEPSVEDKSRLNTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  79 IKTLIGKAAATLIKDGDTVILDSGTTTREIATHLKSRENVVVMTNGLDVAMELANTTGVEVLMTGGVLRKSALSFSGSQA 158
Cdd:NF040755  81 VKRLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537 159 ENSLRNYRFDKVFLGVDGFDLRVGITTHNEQEASLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVTDSGIPD 238
Cdd:NF040755 161 EQSLQNYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPE 240

                        250
                 ....*....|....*.
gi 490364537 239 EYVQELKDHKIDVIIV 254
Cdd:NF040755 241 EYLQGLRKLGVEVILV 256
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-255 1.31e-108

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 314.00  E-value: 1.31e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   1 MKAAvERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAAIPNTGFIAELSIHEKRGQNAGIK 80
Cdd:COG1349    1 MLAE-ERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  81 TLIGKAAATLIKDGDTVILDSGTTTREIATHLKSRENVVVMTNGLDVAMELANTTGVEVLMTGGVLRKSALSFSGSQAEN 160
Cdd:COG1349   80 RAIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537 161 SLRNYRFDKVFLGVDGFDLRVGITTHNEQEASLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVTDSGIPDEY 240
Cdd:COG1349  160 ALRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPEL 239

                        250
                 ....*....|....*
gi 490364537 241 VQELKDHKIDVIIVD 255
Cdd:COG1349  240 LEALEEAGVEVIVAE 254
PRK09802 PRK09802
DeoR family transcriptional regulator;
1-256 3.72e-93

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 275.19  E-value: 3.72e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   1 MKAAVERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAAI--PNTGFIAELSIHEKRGQNAG 78
Cdd:PRK09802  12 VTGTSERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALicDSTTPSVEPSVEDKSALNTA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  79 IKTLIGKAAATLIKDGDTVILDSGTTTREIATHLKSRENVVVMTNGLDVAMELANTTGVEVLMTGGVLRKSALSFSGSQA 158
Cdd:PRK09802  92 MKRSVAKAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537 159 ENSLRNYRFDKVFLGVDGFDLRVGITTHNEQEASLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVTDSGIPD 238
Cdd:PRK09802 172 EQSLQNYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPA 251

                        250
                 ....*....|....*...
gi 490364537 239 EYVQELKDHKIDVIIVDD 256
Cdd:PRK09802 252 DSLEGLRKAGVEVILVGE 269
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 75-234 1.97e-66

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 203.13  E-value: 1.97e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   75 QNAGIKTLIGKAAATLIKDGDTVILDSGTTTREIATHLKSRENVVVMTNGLDVAMELANTTGVEVLMTGGVLRKSALSFS 154
Cdd:pfam00455   1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  155 GSQAENSLRNYRFDKVFLGVDGFDLRVGITTHNEQEASLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVTDS 234
Cdd:pfam00455  81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
7-58 1.48e-14

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 66.09  E-value: 1.48e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 490364537     7 RRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAAI 58
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 6-52 2.56e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.74  E-value: 2.56e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 490364537   6 ERRMEILDMVNQQGKTrVEDLAELFKVSSVTIRSDLSFLEKNGYIVR 52
Cdd:cd00090    7 PTRLRILRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVES 52
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 6-50 9.77e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 36.18  E-value: 9.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 490364537    6 ERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYI 50
Cdd:TIGR01884 143 REELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLV 187
 
Name Accession Description Interval E-value
AgaR NF040755
transcriptional repressor AgaR;
1-254 5.03e-173

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 476.76  E-value: 5.03e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   1 MKAAVERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAAIPNTGFI--AELSIHEKRGQNAG 78
Cdd:NF040755   1 MKGTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALINDGFIpgAEPSVEDKSRLNTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  79 IKTLIGKAAATLIKDGDTVILDSGTTTREIATHLKSRENVVVMTNGLDVAMELANTTGVEVLMTGGVLRKSALSFSGSQA 158
Cdd:NF040755  81 VKRLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537 159 ENSLRNYRFDKVFLGVDGFDLRVGITTHNEQEASLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVTDSGIPD 238
Cdd:NF040755 161 EQSLQNYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPE 240

                        250
                 ....*....|....*.
gi 490364537 239 EYVQELKDHKIDVIIV 254
Cdd:NF040755 241 EYLQGLRKLGVEVILV 256
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-255 1.31e-108

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 314.00  E-value: 1.31e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   1 MKAAvERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAAIPNTGFIAELSIHEKRGQNAGIK 80
Cdd:COG1349    1 MLAE-ERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  81 TLIGKAAATLIKDGDTVILDSGTTTREIATHLKSRENVVVMTNGLDVAMELANTTGVEVLMTGGVLRKSALSFSGSQAEN 160
Cdd:COG1349   80 RAIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537 161 SLRNYRFDKVFLGVDGFDLRVGITTHNEQEASLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVTDSGIPDEY 240
Cdd:COG1349  160 ALRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPEL 239

                        250
                 ....*....|....*
gi 490364537 241 VQELKDHKIDVIIVD 255
Cdd:COG1349  240 LEALEEAGVEVIVAE 254
PRK09802 PRK09802
DeoR family transcriptional regulator;
1-256 3.72e-93

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 275.19  E-value: 3.72e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   1 MKAAVERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAAI--PNTGFIAELSIHEKRGQNAG 78
Cdd:PRK09802  12 VTGTSERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALicDSTTPSVEPSVEDKSALNTA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  79 IKTLIGKAAATLIKDGDTVILDSGTTTREIATHLKSRENVVVMTNGLDVAMELANTTGVEVLMTGGVLRKSALSFSGSQA 158
Cdd:PRK09802  92 MKRSVAKAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537 159 ENSLRNYRFDKVFLGVDGFDLRVGITTHNEQEASLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVTDSGIPD 238
Cdd:PRK09802 172 EQSLQNYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPA 251

                        250
                 ....*....|....*...
gi 490364537 239 EYVQELKDHKIDVIIVDD 256
Cdd:PRK09802 252 DSLEGLRKAGVEVILVGE 269
srlR PRK10434
DNA-binding transcriptional repressor;
6-257 9.18e-74

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 225.34  E-value: 9.18e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   6 ERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAAIPNTGFIaELSIHEKRGQNAGIKTLIGK 85
Cdd:PRK10434   5 QRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEES-DPPIDHKTLINTHKKELIAE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  86 AAATLIKDGDTVILDSGTTTREIATHLKSRENVVVMTNGLDV---AMELANTTgvEVLMTGGVLRKSALSFSGSQAENSL 162
Cdd:PRK10434  84 AAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIvnaLSELDNEQ--TILMPGGTFRKKSASFHGQLAENAF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537 163 RNYRFDKVFLGVDGFDLRVGITTHNEQEaSLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVTDSGIPDEYVQ 242
Cdd:PRK10434 162 EHFTFDKLFIGTDGIDLNAGVTTFNEVY-TVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAFRQ 240

                        250
                 ....*....|....*
gi 490364537 243 ELKDHKIDVIIVDDK 257
Cdd:PRK10434 241 ALEEKGIEVIITGES 255
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 75-234 1.97e-66

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 203.13  E-value: 1.97e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   75 QNAGIKTLIGKAAATLIKDGDTVILDSGTTTREIATHLKSRENVVVMTNGLDVAMELANTTGVEVLMTGGVLRKSALSFS 154
Cdd:pfam00455   1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  155 GSQAENSLRNYRFDKVFLGVDGFDLRVGITTHNEQEASLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVTDS 234
Cdd:pfam00455  81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
6-249 7.10e-29

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 109.56  E-value: 7.10e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   6 ERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHG-AAIPNTGFIAelSIHEKRGQNAGIKTLIG 84
Cdd:PRK10906   5 QRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGgAALPSSSVNT--PWHDRKATQTEEKERIA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  85 KAAATLIKDGDTVILDSGTTTREIATHLKSRENVVVMTNGLDVAMELANTTGVEVLMTGGVLRKSALSFSGSQAENSLRN 164
Cdd:PRK10906  83 RKVASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLDFISQ 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537 165 YRFDKVFLGVDGFDLRVGITTHNEQEASLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVTDSGIPDEYVQEL 244
Cdd:PRK10906 163 FRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQLPPASVMQVI 242


                 ....*
gi 490364537 245 KDHKI 249
Cdd:PRK10906 243 EDHHV 247
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
5-254 1.93e-22

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 92.76  E-value: 1.93e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   5 VERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYI--VRSHGAAIPNTGFIAE-LSIHEKrgQNAGIKT 81
Cdd:PRK13509   4 AQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLkkVRNGAEAITQQRPRWTpMNIHQA--QNHDEKV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  82 LIGKAAATLIKDGDTVILDSGTTTREIATHLKSReNVVVMTNGLDVAMELANTTGVEVLMTGGVLRKS-ALSFSGSQAEN 160
Cdd:PRK13509  82 RIAKAASQLCNPGESVVINCGSTAFLLGRELCGK-PVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSqSITLSPQGSEN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537 161 SLrnYRFDKVF-----LGVDGF---DLrvgITTHNEQEaslnrlMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVT 232
Cdd:PRK13509 161 SL--YAGHWMFtsgkgLTADGLyktDM---LTAMAEQK------MLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLIT 229

                        250       260
                 ....*....|....*....|..
gi 490364537 233 DSGIPDEYVQELKDHKIDVIIV 254
Cdd:PRK13509 230 GKNADPEVLQQLEAQGVSILLV 251
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 6-252 2.14e-18

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 81.67  E-value: 2.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   6 ERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEK-----NGYIVRSHGAAipNTGFIAELS---IHEKRgqna 77
Cdd:PRK10681   7 ERIGQLLQALKRSDKLHLKDAAALLGVSEMTIRRDLNAHSApvvllGGYIVLEPRSA--SHYLLSDQKsrlVEEKR---- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  78 giktLIGKAAATLIKDGDTVILDSGTTTREIATHLKSRENVVVMTNGLDVAMELANTTGVEVLMTGGVLRKSALSFSGSQ 157
Cdd:PRK10681  81 ----RAAQLAATLVEPNQTLFFDCGTTTPWIIEAIDNELPFTAVCYSLNTFLALQEKPHCRAILCGGEFHASNAIFKPLD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537 158 AENSLRNYRFDKVFLGVDGFDLRVGITTHNEQEASLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVTDSGIP 237
Cdd:PRK10681 157 FQQTLDNICPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMAMAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSDRCPD 236

                        250
                 ....*....|....*
gi 490364537 238 DEYVQELKDHKIDVI 252
Cdd:PRK10681 237 DEFVKYAQAQRIKLM 251
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
7-58 1.48e-14

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 66.09  E-value: 1.48e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 490364537     7 RRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAAI 58
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
7-61 1.40e-13

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 63.82  E-value: 1.40e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 490364537    7 RRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAAIPNT 61
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSNS 55
PRK10411 PRK10411
L-fucose operon activator;
1-233 7.77e-13

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 65.98  E-value: 7.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537   1 MKAAveRRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAA------IPNTG--FIAELSIHEK 72
Cdd:PRK10411   1 MKAA--RQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAkyihrqNQDSGdpFHIRLKSHYA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  73 RgqnagiKTLIGKAAATLIKDGDTVILDSGTTTREIATHLKSReNVVVMTNGLDVAMELANTTGVEVLMTGGVLRKSALS 152
Cdd:PRK10411  79 H------KADIAREALAWIEEGMVIALDASSTCWYLARQLPDI-NIQVFTNSHPICQELGKRERIQLISSGGTLERKYGC 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537 153 FSGSQAENSLRNYRFDKVFLGVDGFDLRVGITTHNEQEASLNRLMCDISETIIAVADSTKFGKRSCHMIREFGDIDVLVT 232
Cdd:PRK10411 152 YVNPSLISQLKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIIS 231


                 .
gi 490364537 233 D 233
Cdd:PRK10411 232 D 232
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 6-52 2.56e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.74  E-value: 2.56e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 490364537   6 ERRMEILDMVNQQGKTrVEDLAELFKVSSVTIRSDLSFLEKNGYIVR 52
Cdd:cd00090    7 PTRLRILRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVES 52
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
25-112 5.65e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 37.15  E-value: 5.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490364537  25 DLAELFKVSSVTIRSDLSFLEKNGYIVRSHGAaipntG-FIAELSIHEKRGQNAGIKTLIGKAAATLikdgDTVILDSGT 103
Cdd:COG2188   34 ELAEEFGVSRMTVRKALDELVEEGLLERRQGR-----GtFVAEPKIEYPLSRLTSFTEELRARGREP----STRVLSAER 104

                         90
                 ....*....|.
gi 490364537 104 T--TREIATHL 112
Cdd:COG2188  105 VpaDEEVAEAL 115
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 25-55 7.86e-03

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 34.35  E-value: 7.86e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 490364537  25 DLAELFKVSSVTIRSDLSFLEKNGYIVRSHG 55
Cdd:cd07377   30 ELAEELGVSRTTVREALRELEAEGLVERRPG 60
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
6-53 9.37e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 36.44  E-value: 9.37e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 490364537   6 ERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYIVRS 53
Cdd:COG2345   13 PTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERE 60
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 6-50 9.77e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 36.18  E-value: 9.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 490364537    6 ERRMEILDMVNQQGKTRVEDLAELFKVSSVTIRSDLSFLEKNGYI 50
Cdd:TIGR01884 143 REELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLV 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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