|
Name |
Accession |
Description |
Interval |
E-value |
| PanF |
COG4145 |
Na+/panthothenate symporter [Coenzyme transport and metabolism]; |
1-472 |
0e+00 |
|
Na+/panthothenate symporter [Coenzyme transport and metabolism];
Pssm-ID: 443316 Cd Length: 484 Bit Score: 658.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 1 MQTEVIVPLVGYLLLVFLLSAYAYRKREKGQFLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLS 80
Cdd:COG4145 2 MNLAILIPLLIYLLLVLGIGIYASRKRSKGSFLEEYFLGSRSMGGFVLAMTLAATYTSASSFIGGPGAAYKYGLGWVLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 81 MIQLPAIWLSLGVLGKKFAILARRYNAVTLNDMLYARYQSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEF 160
Cdd:COG4145 82 MIQVPTAFLTLGVLGKKFAILGRKYNAVTLADWLRARYQSKALVLLAALLLLLFFIAFMVAQFVGGARLLETVTGISYTT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 161 GLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAIDPALTSPHGADGILTGPFMA 240
Cdd:COG4145 162 GLLIFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGTVLLLIGVISAGGGIENIMSTLAAIDPNLVSPTGPDGFLPRPFVI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 241 SFWVLVCFGVIGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTVPDQVIPTLMVDVLPPFA 320
Cdd:COG4145 242 SFWILVGFGVIGLPHTAVRCMAYKDSKSLHRAMIIGTIVVGLLMFGMHLIGVLGRAVLPDLTVPDQVIPTLMVKVLPPFL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 321 AGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLA-PHAINNEKRIARLSSLSTLILGILLLFAAWNPPSMIIWLNLLA 399
Cdd:COG4145 322 AGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLNYInPKASENEKKLKRLSKLVTLVLGLIVFLLALNPPDLIIWLNLFA 401
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490365674 400 FGGLQAVFLWPLVLGLYWNKANRYGAIAGMITGATLYATLATFNIQIAGFHPIIPALLLSLVAFLVANRFGEQ 472
Cdd:COG4145 402 FGGLEAAFFWPLVLGLYWKRANATGAIASMLVGVASYFLLYYGNPKIFGFHAIVPSLLISLIAFLIGSLLGKP 474
|
|
| panF |
TIGR02119 |
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is ... |
3-472 |
0e+00 |
|
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is made from aspartate and 2-oxoisovalerate in most bacteria with completed genome sequences. However, some pathogens must import pantothenate. This model describes PanF, a sodium/pantothenate symporter, from a larger family of Sodium/substrate symporters (pfam00474). Several species that have this transporter appear to lack all enzymes of pantothenate biosynthesis, namely Haemophilus influenzae, Pasteurella multocida, Fusobacterium nucleatum, and Borrelia burgdorferi. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A, Transport and binding proteins, Other]
Pssm-ID: 131174 Cd Length: 471 Bit Score: 636.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 3 TEVIVPLVGYLLLVFLLSAYAYRKREKG-QFLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSM 81
Cdd:TIGR02119 1 WEVVIPLIIYLVTVFLIAIYASKRVQSTdSFLNEYFLGGRSMGGFVLAMTLVATYGSASSFIGGPGIAYNYGLGWVLLAM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 82 IQLPAIWLSLGVLGKKFAILARRYNAVTLNDMLYARYQSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFG 161
Cdd:TIGR02119 81 IQVPTGYFVLGVLGKKFAIISRKYNAITINDVLKARYNNKFLVWLSSISLLVFFFSAMVAQFIGGARLIESLTGLSYLTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 162 LLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAIDPALTSPHGADGILTGPFMAS 241
Cdd:TIGR02119 161 LFIFSSSVLIYTTFGGFRAVALTDAIQGIVMFTGTTILLIAVIKAGGGVEKIMEKLKDIDPNLITPFGGDGGLTKPFVAS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 242 FWVLVCFGVIGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTVPDQVIPTLMVDVLPPFAA 321
Cdd:TIGR02119 241 FWILVGIGVIGLPQTAVRCMSYKDSKAMHRAMIIGTIVVGIIMLGMHLAGVLGRAVIPDLTVPDKVIPLLAIKVLPPILA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 322 GIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAInNEKRIARLSSLSTLILGILLLFAAWNPPSMIIWLNLLAFG 401
Cdd:TIGR02119 321 GIFLAAPMAAIMSTVNSLLLQSSSTIIKDLYLNYIPKEA-KESKIKKISMCITLIIGLLVIIAAIKPPDLIIWLNLFAFG 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490365674 402 GLQAVFLWPLVLGLYWNKANRYGAIAGMITGATLYATLATFNIQIAGFHPIIPALLLSLVAFLVANRFGEQ 472
Cdd:TIGR02119 400 GLEAAFIWPIVLGLYWKRANATGALASMIVGVGSYITLESFKPKIFGLHNIVPSLVFALIAFIIGSLFGKK 470
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
5-470 |
0e+00 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 633.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 5 VIVPLVGYLLLVFLLSAYAYR--KREKGQFLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSMI 82
Cdd:cd10327 1 VLLPIIIYLVILLGIGFYARRskKRRSGDFLEEYFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGWVLLAMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 83 QLPAIWLSLGVLGKKFAILARRYNAVTLNDMLYARYQSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGL 162
Cdd:cd10327 81 QVPTGFLTLGVLGKKFAIIARKINAVTIIDYLRARYNSKALVVLSSLALIVFFIAAMVAQFIGGARLLEAVTGLSYVTGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 163 LIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAIDPALTSPHGAdGILTGPFMASF 242
Cdd:cd10327 161 LIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGGGMEAIMATLAEIDPNLLTPFGP-GFLSPPYILSF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 243 WVLVCFGVIGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTVPDQVIPTLMVDVLPPFAAG 322
Cdd:cd10327 240 WVLVGFGVIGLPQTAVRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGVLGRAVLPDLEVPDKVIPTLALKVLPPWLAG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 323 IFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAIN-NEKRIARLSSLSTLILGILLLFAAWNPPSMIIWLNLLAFG 401
Cdd:cd10327 320 LFLAGPLAAIMSTVDSQLILASSAIVKDLYLNYKNKEKKtSEKKVKRISLIITIILGLLVFLLAINPPDLIVWLNLFAFG 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490365674 402 GLQAVFLWPLVLGLYWNKANRYGAIAGMITGATLYATLATFNIQIAGFHPIIPALLLSLVAFLVANRFG 470
Cdd:cd10327 400 GLEAAFFWPLVLGLYWKRANATGALASMVVGLVSYILITYLKIKILGLHPIVPSLLLSLIAFIIVSLAT 468
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
36-432 |
6.54e-128 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 377.45 E-value: 6.54e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 36 YFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSMIQLPAIWLSLGVLGKKFailaRRYNAVTLNDMLY 115
Cdd:pfam00474 1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRL----RNLGAYTMPDYLR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 116 ARYQS-RFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLIFGISIALYTAIGGFRASVLNDALQGLVMLL 194
Cdd:pfam00474 77 KRFGGkRILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 195 GTFILLFAIIYKAGGLDIAIQKLNAIDPALT---SPHGADGILTGPFMASFWVLVCFGVIGLPHTAVRCISYKDSKAMHR 271
Cdd:pfam00474 157 GTIILMIIVFHEVGGYSSAVEKYMTADPNGVdlyTPDGLHILRDPLTGLSLWPGLVLGTTGLPHILQRCLAAKDAKCIRC 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 272 GIIIGTIVMALLMFGM--------HFAGALGRAIIPDLTVPDQVIPTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQS 343
Cdd:pfam00474 237 GVLILTPMFIIVMPGMisrglfaiALAGANPRACGTVVGCSNIAYPTLAVKLGPPGLAGIMLAVMLAAIMSTLTSQLLSS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 344 SATLVKDLYLNLAPHAINNEKRIARLSSLSTLILGILLLFAAWNPPSM-IIWLNLLAFGGLQAVFLWPLVLGLYWNKANR 422
Cdd:pfam00474 317 SSAFTHDLYKNIRRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMgIAFLVQLAFAGLGSAFLPVILLAIFWKRVNE 396
|
410
....*....|
gi 490365674 423 YGAIAGMITG 432
Cdd:pfam00474 397 QGALWGMIIG 406
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
6-469 |
1.95e-100 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 309.05 E-value: 1.95e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 6 IVPLVGYLLLVFLLSAYAYRKREKgqfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSMIQLP 85
Cdd:cd11475 1 LITFIVYLLLMLGIGIYSYRKTKT---LEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAIWIAIGLIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 86 AIWLSLGVLGKKFAILARRYNAVTLNDMLYARYQ--SRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLL 163
Cdd:cd11475 78 GAYLNWLFVAKRLRRYTEKNDSITLPDYLENRFRdkSKLLRILSALIILIFFTIYAAAQLVAGGKLFESLFGIDYSTGLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 164 IFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAIDPALTSPHGADGILTGPFMASFW 243
Cdd:cd11475 158 IGAVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALGGLSGLVAALAAIDPGLLSPFGGDLGAGGLLAIISL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 244 VLVCFGVIGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTV--PDQVIPTLMVDVLPPFAA 321
Cdd:cd11475 238 LAWGLGYFGQPHILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALFPDGLLgdPETVFPVLAQELFPPWLA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 322 GIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAInNEKRIARLSSLSTLILGILLLFAAWNPPSMIIWLNLLAFG 401
Cdd:cd11475 318 GILLAAILAAIMSTADSQLLVCSSALTEDLYKAFLRKEA-SDKELVWVSRLAVLVIALIALLIALNPPSSVFSLVSFAWA 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490365674 402 GLQAVFLWPLVLGLYWNKANRYGAIAGMITGATLYATLATFNIQIAGFHPIIPALLLSLVAFLVANRF 469
Cdd:cd11475 397 GLGAAFGPLLLLSLYWKRTTRQGALAGMIAGAVTVVVWKLLGLGIFGLYEIVPGFLASLLAIVVVSLL 464
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
39-432 |
5.87e-95 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 293.05 E-value: 5.87e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 39 GNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGwvllsMIQLPAIWLSLGVLGKKFAILARRYN-AVTLNDMLYAR 117
Cdd:TIGR00813 1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFA-----IGFYELGALVLLIILGWLFVPIFINNgAYTMPEYLEKR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 118 YQSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTF 197
Cdd:TIGR00813 76 FGKRILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 198 ILLFAIIYKAGGLDIAIQKLNAIDPALTSPHGadgILTGPFMASFWVLVC-FGVIGLPHTA----------VRCISYKDS 266
Cdd:TIGR00813 156 ILPVFAFSEVGGLGTFVEKASQAAPTNPSPDD---LYDFFRDPSTSDLPWgAGVFGLPHVAlwywtnqvivQRCLAAKSA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 267 KAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPD---------LTVPDQVIPTLMVDVLPPFAAGIFLAAPMAAIMSTIN 337
Cdd:TIGR00813 233 KHAKKGCLISGVLKLLPMFGAVLPGLIARALYTDidpalagavNQNSDQAYPLLVQELMPPGLAGLFLAAILAAVMSTLS 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 338 AQLLQSSATLVKDLYLNLAPHAINNEKRIARLSSLSTLILGILLLFAAWNPPSMIIWLNLLAFGGLQAVFLWPLVLGLYW 417
Cdd:TIGR00813 313 SQLNSASTVFTMDLYKKIIRPNASGEKKIVMRGRIAVLVAAVIAGFVAAAQGGQVLQYVQEAFGGLGAPFLPVFLLGIFW 392
|
410
....*....|....*
gi 490365674 418 NKANRYGAIAGMITG 432
Cdd:TIGR00813 393 KRMNAKGALAGMIAG 407
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
1-473 |
6.96e-92 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 287.48 E-value: 6.96e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 1 MQTEVIVPLVGYLLLVFLLSAYAYRKREKgqfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLS 80
Cdd:COG0591 1 MSTLDLIIIILYLLLLLGIGLYASRRTKS---LEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 81 MIQLPAIWLSLGVLGKKFailaRRYNAVTLNDMLYARYqSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEF 160
Cdd:COG0591 78 LGYALGALLLALFFAPRL----RRLGALTIPEFLEKRF-GRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 161 GLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAidPALTSPHGADGILTGPFMA 240
Cdd:COG0591 153 GILIGALIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALGGFGELFAALPA--PGLLSLFPGLGFTGWLAFL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 241 SFWVLVCFGVIGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTV--PDQVIPTLMVDVLPP 318
Cdd:COG0591 231 GLFLAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLPLadPDLALPLLILELLPP 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 319 FAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAInNEKRIARLSSLSTLILGILLLFAAWNPPSMIIWLNLL 398
Cdd:COG0591 311 GLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKA-SDKQLLRVSRLAVLVVGLLALLLALLFPSSILDLVLL 389
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490365674 399 AFGGLQAVFLWPLVLGLYWNKANRYGAIAGMITGATLYATLATFNI---QIAGFHPIIPALLLSLVAFLVANRFGEQT 473
Cdd:COG0591 390 AWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLGGplgPFGWLYPILPGLLVSLLVFVVVSLLTKPP 467
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
5-467 |
2.33e-86 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 272.51 E-value: 2.33e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 5 VIVPLVGYLLLVFLLSAYAYRKREKgqfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSMIQL 84
Cdd:cd10322 2 DLIIVVVYLALLLGIGLYASKKVKS---SEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 85 PAIWLSLGVLGKKFailaRRYNAVTLNDMLYARYQSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLI 164
Cdd:cd10322 79 LGALLLALFLAPRL----RRLGKTTIPETILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVII 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 165 FGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGldIAIQKLNAIDPALTSPHGADGILTGPFMASFWV 244
Cdd:cd10322 155 AAVIVILYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGG--GGFSALAAALPALLLALGPGGGLGWSTILSLIL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 245 LVCFGVIGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTVPDQVIPTLMVDVLPPFAAGIF 324
Cdd:cd10322 233 LTGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLENPDLALPTLINSLLPPGLAGLV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 325 LAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAInNEKRIARLSSLSTLILGILLLFAAWNPPSMIIWLNLLAFGGLq 404
Cdd:cd10322 313 LAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKA-SDKKLLRVSRIAVVVVGVLALLLALLPPSILLLLSLAAGLLA- 390
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490365674 405 AVFLWPLVLGLYWNKANRYGAIAGMITGATLYA-TLATFNIQIAGFHPIIPALLLSLVAFLVAN 467
Cdd:cd10322 391 AALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLvWLLLPLASPLGIDPIIPALLVSLIVFVVVS 454
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
9-466 |
6.26e-40 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 150.42 E-value: 6.26e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 9 LVGYLLLVFLLSAYAYRKREKGqfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIgwvllSMIQLPAIW 88
Cdd:cd11477 6 IALYFLLMLGIGLWFSKRASKS--TSDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGI-----AGNWIWWLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 89 LSLGVLGKK-FAILARRYNAVTLNDMLYARYQSRFLVW----FASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLL 163
Cdd:cd11477 79 AVAGLIGAFvFARRWRRLRVLTDGEFPEERYGGRYGAPlrqfYAVYFALLSNVDILAWVFLAAIKVSAVFGPWDPWLTIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 164 IFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAIDPALTSPHGADGILTGPFMASFW 243
Cdd:cd11477 159 ILGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVGGPGGLFAQLPEGHLDLFGSGLGASGFYITFFFILF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 244 VLV--CFGVIGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTVP----DQVIPTLMVDVLP 317
Cdd:cd11477 239 FGWypLSYSGGGWYLAQRYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPALAALVLYPDLDDPeadfELAYPMMIKEYLP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 318 PFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNL-APHAinNEKRIARLSSLSTLILGILLLFAAWNPPSM--IIW 394
Cdd:cd11477 319 AGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFiKPNA--SEKHLLKVGRLATVLFGLLSIVVALASDSIggAFW 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490365674 395 LNLLAFGGLQAVFLWPLVLGLYWNKANRYGAIAGMITGATLYATLATFNIQIAGFHPIIPALLLSLVAFLVA 466
Cdd:cd11477 397 IVLALGAGLGGPLILPWLWWRFNAWTEIWAMIASIIVGLVVSVLLKVFGLPEDFLFSFLVPVLLSLVVWLAV 468
|
|
| YidK |
COG4146 |
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ... |
1-439 |
1.65e-39 |
|
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];
Pssm-ID: 443317 [Multi-domain] Cd Length: 444 Bit Score: 147.98 E-value: 1.65e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 1 MQTEVIVPLVGYLLLVFLLSAYAYRKREKGQfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLS 80
Cdd:COG4146 3 LSTLDYIVFLLYFLLVAGIGYWVSRKKKEKT-SEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAAYE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 81 MIqlpAIWlSLGVLGKKFAILARRYNAVTLNDMLYARYQSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEF 160
Cdd:COG4146 82 WM---AAI-ALIILALFFLPFYLKSGIYTMPEFLEKRYDRRTRTILSILFLVSYVFVNLPSVLYAGALALNTIFGVPLWI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 161 GLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAI----------QKLNAIDPALTSPHGA 230
Cdd:COG4146 158 SVIGLGIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGDGSVLAgwsallkvppEKFNMIGPADDPDLPW 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 231 DGILTGPFMASFWVLVCFGVIglphtAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTV-PDQVIP 309
Cdd:COG4146 238 LGIFTGMPILNLFYWGTNQYI-----VQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGLDnPDQAYP 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 310 TLMVDVLPPFAAGIFLAAPMAAIMSTINAqLLQSSATL-VKDLYLNLAPHAINNEK--RIARLSSLSTLILGILLLFAAW 386
Cdd:COG4146 313 TLVKNLLPVGLKGLVAAALFAAIMSSLAS-ALNSSSTLfTLDIYKKYFNPNASEKQlvKVGRIATVVLAVIAILIAPLIG 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 490365674 387 NPPSMIIWLN-LLAF--GGLQAVFLwplvLGLYWNKANRYGAIAGMITGATLYATL 439
Cdd:COG4146 392 NADGLFQYIQeVTGFfsPPILAVFL----LGLFWKRVTAKAAKVALIAGIVLSILL 443
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
6-466 |
8.97e-38 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 143.82 E-value: 8.97e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 6 IVPLVGYLLLVFLLSAYAYRKREKGQflnEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVllsmIQLP 85
Cdd:cd11474 1 LIGVILYYLLILGIGLWASRRVKSSE---DFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGV----AQDP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 86 -AIWLSLGVLGKKFAILARRYNAVTLNDMLYARYqSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLI 164
Cdd:cd11474 74 fGYALCLILGGLFFAKPMRRMGLLTLGDFFRQRY-GRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGILI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 165 FGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDI---AIQKLNAIDPALTSPHGAdgiltGPFMAS 241
Cdd:cd11474 153 SAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIasaAAAGKLRFFPWLGTKSDW-----LIWIDA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 242 fWVLVCFGviGLPHTAV--RCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTV------PDQVIPTLMV 313
Cdd:cd11474 228 -WLTLGLG--SIPQQDVfqRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQygleedAQLILPLLLQ 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 314 DVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLY-LNLAPHAinNEKRIARLSSLSTLILGILLLFAAWNPPSmI 392
Cdd:cd11474 305 YLTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYkPPFRPKA--SDRELLWVMRISVVVFGAIATLMALTVES-I 381
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490365674 393 IWLNLLAFGGLQAVFLWPLVLGLYWNKANRYGAIAGMITGATLYATL-ATFNIQIAGFHPIIPALLLSLVAFLVA 466
Cdd:cd11474 382 YGLVELASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGgELLLGLPADIPPQLQGFPFSTLAMVIG 456
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
7-466 |
1.83e-36 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 140.33 E-value: 1.83e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 7 VPLVGYLLLVFLLSAYAYRKREKGqfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGwvllsmiqlpA 86
Cdd:cd11480 1 IGLFFVFVTITLYITIWAARRTRS--TSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYD----------G 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 87 IWLSLGVLGKkFAILA-------RRYNAVTLNDMLYARYQSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYE 159
Cdd:cd11480 69 LAYAIGWTGG-YVLLLllvaeplRNFGKYTVPDFLGARLGSRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIPYE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 160 FGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAIDPALTSPHGADGILT-GPF 238
Cdd:cd11480 148 VGVVVVGALMIVYVVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGNPLGAGPGLLGLAAAAASGAGEAYLApGLL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 239 MASFWVLVC------FGVIGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTV--------- 303
Cdd:cd11480 228 LTDPLDVISltlalmLGTAGLPHVLMRFYTVPDARAARKSVVWALGFIGLFYLLAPALGFGARALVGPDVIgapiageld 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 304 --PDQVIPTL-MVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAInNEKRIARLSSLSTLILGIL 380
Cdd:cd11480 308 ggGDMAVLLLpEIAGLGDLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAGVIRPGA-SERREVRVARIAAVVVGVI 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 381 -LLFAAWNPPSMIIWLNLLAFGGLQAVFLWPLVLGLYWNKANRYGAIAGMITG--ATLYATLATFNIQI-------AGFH 450
Cdd:cd11480 387 aILLALLFPPQNVAFLVALAFAIAASAFFPVLVLGIFWRRFTTRGAIAGMLVGllVSLVLIVLSPAVSGappghdfAGFP 466
|
490
....*....|....*.
gi 490365674 451 PIIPALLLSLVAFLVA 466
Cdd:cd11480 467 LTNPGLVSVPLGFLVA 482
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
6-465 |
2.10e-35 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 138.09 E-value: 2.10e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 6 IVPLVGYLLLVFLLSAYAYRKREKGqfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGW--------- 76
Cdd:cd10329 1 IVIIAVYFVAVIAIGLWSSRKKRST--VSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASGIAVgnyewnaaf 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 77 --VLLSMIQLPaIWLSLGVlgkkfailarrynaVTLNDMLYARYQSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAA 154
Cdd:cd10329 79 vlLLLGWVFLP-FYIRSGV--------------STMPEFLEKRFGGRSRVYLSVLSLILYVFTKISVDLYAGALVIKQLL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 155 GIPYEFGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQ-------KLNAIDPALTSP 227
Cdd:cd10329 144 GWDLYLSIIVLLVITAIYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGGGWSAYMaaipsgtAFHLFRPPDDPD 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 228 HGADGILTGPFMASFWVLVCFGVIglphtAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTV---- 303
Cdd:cd10329 224 LPWPGLLLGYPILGIWYWCTDQVI-----VQRVLAAKNLKHARRGALFAGYLKLLPLFLMVLPGMIARALFPDLVAcvvp 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 304 -------PDQVIPTLMVDVLPPFAAGIFLAAPMAAIMSTInAQLLQSSATLV-KDLYLNLAPHAINNE-KRIARLSSLST 374
Cdd:cd10329 299 cgngvgcSDIAYPTLVTELLPVGLRGLVLAVLLAALMSSL-TSIFNSASTLFtMDIYKRLRPEASEKElVRVGRIATLVV 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 375 LILGILllfaaWNPPSMIIWLNLlaFGGLQAV--FLWP-----LVLGLYWNKANRYGAIAGMITGATL----------YA 437
Cdd:cd10329 378 VVISIL-----WAPIIQAQGGSL--FNYIQSVlsYLAPpiaavFLLGIFWKRTNEQGAFWGLIAGLVLglvrlilefaYG 450
|
490 500
....*....|....*....|....*...
gi 490365674 438 TLATFNIQIAGFHPIIPALLLSLVAFLV 465
Cdd:cd10329 451 EPDTRPAIIGGIHFLYFAFLLFVVSVIV 478
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
6-473 |
2.21e-35 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 136.96 E-value: 2.21e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 6 IVPLVGYLLLVFLLSAYAYRKrekGQFLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGI-GWVLLSMIQL 84
Cdd:cd11479 3 YGVIALYFAAMIAIGWWGMRR---AKTSEDYLVAGRRLGPGLYLGTMAAVVLGGASTIGGVGLGYQYGIsGMWLVVAIGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 85 PAIWLSLGVLGKkfailARRYNAVTLNDMLYARYQSRFLVWFASLSLLVAFVGAMTvQFIGGARLLETAAGIPYEFGLLI 164
Cdd:cd11479 80 GILALSLLLAKR-----IARLKVYTVSEVLELRYGPSARVISALVMLAYTLMVAVT-STIAIGTVFSVLFGLPRTLSILV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 165 FGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAI-IYKAGGLDIAIQKLNAIDPALTSPhGADGILTgpfmasFW 243
Cdd:cd11479 154 GGGIVVLYSVLGGMWSITLTDIIQFVIKTIGIFLLLLPLaLSKAGGLSGLQEKLPASYFDLTSI-GWDTIVT------YF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 244 VLVCFGVIGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTVPDQVIPTLMVDVLPPFAAGI 323
Cdd:cd11479 227 LLYFFGILIGQDIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVLLPDLANPQNAFATMAQEVLPVGLRGL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 324 FLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAINNEKRIaRLSSLSTLILGILLLFAAwnppsmiIWLN------L 397
Cdd:cd11479 307 VLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEV-RLSRLFTLLLGVVVIVIA-------VLVNdvvaalT 378
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490365674 398 LAFGGLQAVFLWPLVLGLYWNKANRYGAIAGMITGATlyATLATFNIQ-IAGFHPIIPALLLSLVAFLVANRFGEQT 473
Cdd:cd11479 379 IAYAILVGGLLVPILGGLFWKRATGAGALASMVAGSV--VVLAGMAVDgLLANTPIYYGLAVSLVAFVAVSLLTRPT 453
|
|
| SLC5sbd_NIS-like_u3 |
cd11495 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
9-466 |
9.46e-34 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271386 [Multi-domain] Cd Length: 473 Bit Score: 132.66 E-value: 9.46e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 9 LVGYLLLVFLLSAYAYRKREKGqflNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSMIQLPAIW 88
Cdd:cd11495 9 LVIYLLAMLGIGLYFSKKQKST---DDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSIIIAAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 89 LSLGVlgkkFAILARRYNAVTLNDMLYARYqSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLIFGIS 168
Cdd:cd11495 86 LAAYF----FVPFFRRLNVTSAYEYLEKRF-GPWARVYGSLLFILFQLGRMGIVLYLPALALSAVTGINPYIIIILMGVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 169 IALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKA-GGLDIAIQKLNAIDPALTSPHGADgiLTGPfmaSFWVLVC 247
Cdd:cd11495 161 CIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIpGGFGEVFDIAIANGKFSLGDFSFS--LTES---TIWVIFI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 248 FGVI------GLPHTAV-RCISYKDSKAMHRGIIIG---TIVMALLMFGM--------HFAGALgraiIPDLTVPDQVIP 309
Cdd:cd11495 236 GGIFnnlqsyTSDQDVVqRYLTTKSIKEAKKSLWTNallALPVALLFFGIgtalyvfyQQHPEL----LPAGINGDAVFP 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 310 TLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAINNEK-RIARLSSLSTLILGIL--LLFAAW 386
Cdd:cd11495 312 YFIVTQLPVGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYKRLSPDPSDKQYlKVARLITLLVGLLGTLvaLYLANA 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 387 NPPSMIIWLNLLA---FGGLQAVFLwplvLGLYWNKANRYGAIAGMITGAtlyatLATFNIQIagFHPIIPALLLSLVAF 463
Cdd:cd11495 392 GVKSLLDAFNTLTglfGGGLAGLFL----LGIFTKRANAKGALVGIIVSI-----IVIFWISL--LYTPIHFFLYSVIGT 460
|
...
gi 490365674 464 LVA 466
Cdd:cd11495 461 LVC 463
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
5-432 |
2.43e-31 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 126.16 E-value: 2.43e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 5 VIVPLVGYLLLVFLLSAYAYRKREKGQFLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSmiql 84
Cdd:cd11476 4 VIGLGALFALLMVFITRLLKRYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVSGPFWY---- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 85 pAIWLSLGVLgkKFAILARRY-----NAVTLNDMLYARYQSRFLVWFASLSLLVAFVgAMTVQFIGGARLLETAAGIPYE 159
Cdd:cd11476 80 -ASGATLQIL--LFAPLAIRIkrlapNAHTLLEIVRARYGTAAHLVFLVFALFTNVI-VLAMLLLGGSAVVNALTGMPIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 160 FGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKA--GGLDIAIQKLNAIDPALTSPHGADGILT-- 235
Cdd:cd11476 156 AASFLIPLGVLLYTLFGGLRATFLTDYIHTVIILIILLVFAFAVYTSSdiGSPSKVYDLLQEAAPDLPVEGNQGSYLTfk 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 236 -GPFMASFWVLVCFG---VIGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAG----ALGRAIIPDLTVPDQV 307
Cdd:cd11476 236 sKAGLIFGIINIVGNfgtVFLDQGYWQRAIAARPSAAVKGYFLGGLAWFAIPFLLATTLGlaalALGLNPTFEEVSAGLV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 308 IPTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLY-LNLAPHAINneKRIARLSSLSTLILGILLLFAAW 386
Cdd:cd11476 316 LPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYrTYINPNATG--KQLLRVSRIAVIGFGLFMGGLAV 393
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 490365674 387 NPPSM---IIWLnLLAFGGLQAVFLWPLVLGLYWNKANRYGAIAGMITG 432
Cdd:cd11476 394 GLNYIgisLGWL-LLFMGILIGSAVFPVALGLYWRRQTGTAAVVSPIAG 441
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
7-466 |
6.12e-30 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 122.57 E-value: 6.12e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 7 VPLVGYLLLVFLLSAY---AYRKREKGqfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSMIQ 83
Cdd:COG4147 12 LLAIGIFLVFVTFTLYitiWAARRTKS--TSDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLIYSIGW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 84 LPAiWLSLGVLgkkFAILARRYNAVTLNDMLYARYQSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLL 163
Cdd:COG4147 90 LVG-YVLLLLL---LAEYLRNFGKFTVPDFLGDRFYSRPARLVAAISTLVVSFFYLIAQMVGAGVLISLLLGVDYEVAVV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 164 IFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIA-IQKLNAIdpaltSPHGADGILTGPFMASF 242
Cdd:COG4147 166 IVGVLMIVYVVLGGMKGTTWVQIIKAVLLIFAYTVPAVLVLAQFGFNPLPlLAKAAEV-----HDLGAAYLEPGGLVKSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 243 WVLVC------FGVIGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTVPDQVIPTLMVD-- 314
Cdd:COG4147 241 LDFISlglalmLGTAGLPHILMRFFTVPDAKEARKSVGWALGFIGLFYLTAPALGFGARALVGPLPEWFDTGLIGAADgg 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 315 ------------VLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLN-LAPHAI-NNEKRIARLSSLSTLILGIL 380
Cdd:COG4147 321 gnmavlalaeiaGGGNWLLGLVAAGAFATILAVVAGLLLAIASAISHDLYANvIKGKATeKEELRVARIAAVVIGVVAIL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 381 LLFAAwnPPSMIIWLNLLAFGGLQAVFLWPLVLGLYWNKANRYGAIAGMITG--ATLYATLATFNIQIAGFHPII----- 453
Cdd:COG4147 401 LGINA--PPQNVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGliSALVLIVLSPFVWVLGVDAALfplen 478
|
490
....*....|...
gi 490365674 454 PALLLSLVAFLVA 466
Cdd:COG4147 479 PGLVSMPLGFLVA 491
|
|
| PRK15419 |
PRK15419 |
sodium/proline symporter PutP; |
1-471 |
7.83e-29 |
|
sodium/proline symporter PutP;
Pssm-ID: 185317 Cd Length: 502 Bit Score: 118.97 E-value: 7.83e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 1 MQTEVIVPLVGYLLLVFLLSAYAYRKREKgqfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLS 80
Cdd:PRK15419 3 ISTPMLVTFCVYIFGMILIGFIAWRSTKN---FDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 81 MIQLPAIWLSLGVLGKKFAILAR-RYNAVTLNDMLYARYQ--SRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIP 157
Cdd:PRK15419 80 IGLTLGAWINWKLVAGRLRVHTEyNNNALTLPDYFTGRFEdkSRILRIISALVILLFFTIYCASGIVAGARLFESTFGMS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 158 YEFGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAidpalTSPHGADgILTGP 237
Cdd:PRK15419 160 YETALWAGAAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFGDSLEVIKQ-----KSIENVD-MLKGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 238 FMASFWVLVCFGV--IGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAII---PDLTVP-----DQV 307
Cdd:PRK15419 234 NFVAIISLMGWGLgyFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFnehPAVAGAvnqnaERV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 308 IPTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAInNEKRIARLSSLSTLILGILLLFAAWN 387
Cdd:PRK15419 314 FIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHA-SQKELVWVGRVMVLVVALVAIALAAN 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 388 PPSMIIWLNLLAFGGLQAVFLWPLVLGLYWNKANRYGAIAGMITGATLYATLATFNiqIAGFHPIIPALLLSLVAFLVAN 467
Cdd:PRK15419 393 PENRVLGLVSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGALTVIVWKQFG--WLGLYEIIPGFIFGSIGIVVFS 470
|
....
gi 490365674 468 RFGE 471
Cdd:PRK15419 471 LLGK 474
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
12-466 |
1.20e-28 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 118.16 E-value: 1.20e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 12 YLLLVFLLSAYAYRKREKGqflNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGI------------GWVLL 79
Cdd:cd11478 9 YFVFVLGIGFYLKRKVKTS---EDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGIatvhfywigaipAMVFL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 80 SMIQLPAIWLSL-----GVLGKKFAILARRYNAVTlndmlyaryqsrFLVWFASLSllvafvgamTVQFIGGARLLETAA 154
Cdd:cd11478 86 GIVMMPFYYGSKvrsvpEYLKLRFNKSTRLLNAVS------------FAVMTILMS---------GINLYALALVLNVLL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 155 GIPYEFGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAIDPALTSPH---GAD 231
Cdd:cd11478 145 GWPLWLSIILSAAIVLAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGGWDGLSEKIDANGPPGWNGLswgPQG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 232 GILTGPFMASFWVLVCFG-VIGL-----PHTAV-RCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLTV- 303
Cdd:cd11478 225 SQSTNPMGVNLGLVFGLGfVLSFgywttNFLEVqRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLVPELGAs 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 304 ----PDQVIPTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYlnlAPHAINNEK-----RIARLSSLST 374
Cdd:cd11478 305 ggldYNQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIY---QTYIVKDAPdkhylKVGRIATVVG 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 375 LILGILLLFAAWNPPSMIIWLNLLaFGGLQAVFLWPLVLGLYWNKANRYGAIAGMI--TGATLYATLATFNIQIAGFHPI 452
Cdd:cd11478 382 VLISIGTAYIASSFNNIMDYLQLL-FSFFNAPLFATFLLGMFWKRATPWGGFWGLLagTASAIVLYGLYELGLIVYHSDM 460
|
490
....*....|....
gi 490365674 453 IPALLLSLVAFLVA 466
Cdd:cd11478 461 APNFYGAWWAFVVC 474
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
9-465 |
3.40e-27 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 113.85 E-value: 3.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 9 LVGYLLLVFLlsaYAYRKREKGQFLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSmIQLPaiw 88
Cdd:cd11494 6 LVGYLLGILV---YGVYKGRGQKNQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVQYY-FGLP--- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 89 LSLGVLGKKFAILARRYNAVTLNDMLYARYQSRFLVWFASLSLLVAFVGAMTVQFIgGARLLETAAGIPYEFGLLIFGIS 168
Cdd:cd11494 79 LAMIFLCITFVPVFYKLKVYTAYEYLERRFGLKTRLLTSILFLISRGLATGVTIYA-PAIILSTILGWSLWLTILLIGGI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 169 IALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYK-------AGGLDIAIQKLNAIDpalTSPHGAD--GILTGPFM 239
Cdd:cd11494 158 TIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLlpvgfvdALLVAGKSGRLNALD---FSFDLSDtyTFWSGLIG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 240 ASFWVLVCFGVIGLphTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGAL-------------GRAIIPDLTVPDQ 306
Cdd:cd11494 235 GFFLYLSYFGTDQS--QVQRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVLvfvfyqfnpfpvsFNPAEDETKDTNY 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 307 VIPTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAiNNEKRIARLSSLSTLILGILLL---F 383
Cdd:cd11494 313 IFLRFVLNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKD-ASDEHYLKVSRLLTVFWGLLAIvfaL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 384 AAWNPPSMIIWLNLL---AFGGLQAVFLwplvLGLYWNKANRYGAIAGMITGATLYATLATFNIQIAGFHPIIPALLLSL 460
Cdd:cd11494 392 FAGLAGSLIEAVNKLgslFYGPILGVFL----LAFFTKKANGKGVFAGAILGVIVVIVLWLFPDVSWLWWNVIGCVVVIG 467
|
....*
gi 490365674 461 VAFLV 465
Cdd:cd11494 468 VALLL 472
|
|
| SLC5sbd_NIS-like_u1 |
cd11493 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
9-466 |
2.05e-22 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271384 [Multi-domain] Cd Length: 479 Bit Score: 99.60 E-value: 2.05e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 9 LVGYLLLVFLLSAYAYRKREKgqfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSMIQLPAIW 88
Cdd:cd11493 5 IVLYLLGLPLLGLWLSGRQKS---TADYFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLQLALGYILGRI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 89 LSLGVLGKKFailaRRYNAVTLNDMLYARYQSRfLVWFASLSLLVA---------FVGAMTVQFIGGARLLEtaagIPYE 159
Cdd:cd11493 82 IVAFVLLPRY----FRGEVVSAYELLGQRFGGG-MQKTASVTFLVTrlladgvrlFAAAIPVSMILGADGVA----LSYI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 160 FGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTfILLFAIIYKAGGLDIAIQKLNAIDPALTSPHGADGILTGPFm 239
Cdd:cd11493 153 ASILIISVVTLLYTYFGGIRAVVWTDVIQLVVYIGGA-VAALAYLLGALPADWLQIAAAAGKFHLFDLSDLILGLTSPY- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 240 aSFWVLVCFGVI------GLPHTAVR----CISYKDS-KAMHRGIIIGTIVMALLMF-GMHFAGALGRAIIPDLTV--PD 305
Cdd:cd11493 231 -TFWAAIIGGALlsmashGTDQLMVQrllaCRNLRDAqKALIGSGVVVFPQFALFLLiGLLLYVYYGGASLAALGLgsPD 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 306 QVIPTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAINNEK--RIARLSSL--STLILGILL 381
Cdd:cd11493 310 EVFPYFIVHELPAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRRRLSDEKllRASRLLTLvwAVVLVGIAL 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 382 LFAAWNPPSMIIWLNLLAF--GGLQAVFLwplvLGLYWNKANRYGAIAGMITGATLYATLaTFNIQIAGFHPIIPALLLS 459
Cdd:cd11493 390 LFQYTDQPVVELGLSIASFtyGGLLGVFL----LGLLTRRASQRDAIAAFIVGFLVMLLL-IFGVKFLGLLFALAFPWYV 464
|
....*..
gi 490365674 460 LVAFLVA 466
Cdd:cd11493 465 PIGTLVT 471
|
|
| SLC5sbd_NIS-SMVT |
cd11492 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
12-432 |
1.28e-21 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271383 [Multi-domain] Cd Length: 522 Bit Score: 97.56 E-value: 1.28e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 12 YLLLVFLL--SA-----YAYRKReKGQFLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIG--WVLLSM- 81
Cdd:cd11492 3 YVVFVAMLliSAaigiyFGFFGG-KQKTTEEYLLGGRNMSVFPVALSLIASFISGITLLGTPAEIYYYGTQywLIVIAYv 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 82 IQLPAIWL-------SLGV------LGKKFAILARRYNAV--TLNDMLYaryqsrflvwfasLSLLVaFVGAMTvqfigg 146
Cdd:cd11492 82 LVGPITAYiflpvfyNLQLtsvyeyLELRFNRRVRLLASFlfILQMLLY-------------LPIVI-YAPALA------ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 147 arlLETAAGIPYEFGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQK--------LN 218
Cdd:cd11492 142 ---LSQVTGINLHIIILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDVGGFSEVWEIaeeggrleFF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 219 AIDPALTSPHgadgiltgpfmaSFWVLVcFGVIG--LPHTAV------RCISYKDSKAMHRGIIIGTIVMALLMFGMHFA 290
Cdd:cd11492 219 NFDPDPTVRH------------TFWSLV-IGGTFtwLSLYGVnqtqvqRYLSLPSLKSAKKALWLNIVGLILILSLCCFT 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 291 GAL-------------GRAiipdlTVPDQVIPTLMVDVLPPF--AAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNL 355
Cdd:cd11492 286 GLViyakyhdcdpltaGLI-----KKPDQLLPYFVMDVLGHLpgLPGLFVAGIFSAALSTLSSGLNSLAAVILEDFIKPF 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 356 APHaINNEKRIARLSSLSTLILGIL---LLFAAWNpPSMIIWLNLLAFGGLQAVFLWPLVLGLYWNKANRYGAIAGMITG 432
Cdd:cd11492 361 FKK-KLSERQATNIMKLLVVVFGLLcigLAFLVEK-LGGVLQLSLSIFGITGGPLLGIFTLGMFFPWANSKGALVGLLVG 438
|
|
| SLC5sbd_SGLT1 |
cd11486 |
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ... |
6-432 |
6.34e-21 |
|
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.
Pssm-ID: 271379 Cd Length: 636 Bit Score: 95.77 E-value: 6.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 6 IVPLVGYLLLVFLLSAYAYRKREKGQfLNEYFLGNRSMGGFVLAMTITATYVSASSFIG--GPGAAYKYGIG---WVLLS 80
Cdd:cd11486 3 ISVIVIYFVVVLAVGVWAMVSTNRGT-VGGFFLAGRSMVWWPIGASLFASNIGSGHFVGiaGTGAAAGIAIGgfeWNALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 81 MIQlpaiwlslgVLGKKFAILARRYNAVTLNDMLYARYQ-SRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYE 159
Cdd:cd11486 82 VVV---------VLGWLFVPIYIKAGVVTMPEYLRKRFGgQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLY 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 160 FGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQK-LNAIDPALTS------------ 226
Cdd:cd11486 153 LAIVILLAITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFMEKyMTAIPSVIGTgnstsqekcytp 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 227 ----------PHGAD----GILTGPFMASFWVLVCFGVIglphtAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGA 292
Cdd:cd11486 233 radsfhifrdPITGDlpwpGLLFGLSILTLWYWCTDQVI-----VQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGM 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 293 LGRAIIPDL---TVPDQ--------------VIPTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNL 355
Cdd:cd11486 308 ISRILYTDEiacVVPDEckavcgtevgctniAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKV 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 356 APHAINNEKRIA-RLSSLstLILGILLlfaAWNPPSMIIWLNLLaFGGLQAV--FLWP-----LVLGLYWNKANRYGAIA 427
Cdd:cd11486 388 RKKASEKELMIAgRLFML--VLIGISI---AWVPIVQSAQSGQL-FDYIQSItsYLGPpiaavFLLAIFCKRVNEPGAFW 461
|
....*
gi 490365674 428 GMITG 432
Cdd:cd11486 462 GLCVG 466
|
|
| SLC5sbd_NIS-like |
cd10326 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
5-466 |
4.07e-20 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 92.62 E-value: 4.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 5 VIVPLVGYLLLVFLLSAYAYRKREKgqfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYgiGWVLLSMIQl 84
Cdd:cd10326 1 DWAVVVVYFLILLAISYYTSRRNAD---NDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGS--GFTYLQMVL- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 85 pAIWLSLGVLGKKFAILARRYNAVTlndmLYARYQSRFLVWF----ASLSLLVAFVGAMTVQFIGG---ARLLETAAGIP 157
Cdd:cd10326 75 -GFLLGYLIIAFVLLPLYYRLNLTS----IYEYLEDRFGVSSrktgAVFFLLSRILGAGIRLYLVAlvlQQFLFDSLGIP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 158 YEFGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAIDPALTSPHGADG----- 232
Cdd:cd10326 150 FWLTVLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGLGFGEAISAAGESGYSRIFNFDDDnsrrt 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 233 ILTGPFMASFWVLVcfgVIGLPHTAVR----CISYKDS-KAMHRGIIIGTIVMALLMF--GMHFAGALGRAIIPDLTVPD 305
Cdd:cd10326 230 FWKQFLGGIFITIA---MTGLDQDMMQrnlsCKNLKDAqKNMLTFGVILVPVNLLFLLlgVLLYTYAQKNGIALPAKDSD 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 306 QVIPTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLY-LNLAPHAINNEKRIARLSSLSTLILGILLLFA 384
Cdd:cd10326 307 QLFPYFALNGLPPGVSGLFVAGIIAAAMSSADSALTALTTSFCVDILnRFKRKSEKKSERKYVHIAFSLTFVLGILVFGS 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 385 AWNPPSMIIWLNLLA---FGGLQAVFLwplvLGLYWNKAN--RYGAIAGMITGATLYatLATFNIQIAGFHPIIPALLLS 459
Cdd:cd10326 387 ASNSGSLIDAIFKVAgytYGPLLGLFA----FGLFTKRAVkdKWVPLVGLLAPVLSY--LLVSNSEGFFGYKFGFELLII 460
|
....*..
gi 490365674 460 LVAFLVA 466
Cdd:cd10326 461 NGLLTFL 467
|
|
| SLC5sbd_SGLT4 |
cd11488 |
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ... |
6-432 |
2.83e-19 |
|
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.
Pssm-ID: 271380 Cd Length: 605 Bit Score: 90.76 E-value: 2.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 6 IVPLVGYLLLVFLLSAYAYRKREKGQfLNEYFLGNRSMGGFVLAMTITATYVSASSFIG--GPGAA-------YKYGIGW 76
Cdd:cd11488 2 IAVVVVYFVFVLAVGIWSSIRASRGT-VGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGlaGTGAAgglavggFEWNAAW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 77 VLLSM--IQLPaIWLSLGVlgkkfailarrynaVTLNDMLYARYQ-SRFLVWFASLSLLVAFVGAMTVQFIGGARLLETA 153
Cdd:cd11488 81 VLIALgwIFVP-VYIAAGV--------------VTMPEYLKKRFGgQRIRIYMSVLSLILYIFTKISTDIFSGALFIQVS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 154 AGIPYEFGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAIDPALTSPH----- 228
Cdd:cd11488 146 LGWNLYLSTVILLAVTALYTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKVGWYPGLEQQYEKAIPALTVPNttchl 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 229 ---GADGILTGPFMASF-WVLVCFGVIGLPH--------TAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRA 296
Cdd:cd11488 226 prsDAFHIFRDPVTGDIpWPGLIFGLTVLATwvwctdqvIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 297 IIPD---LTVPDQVI--------------PTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHA 359
Cdd:cd11488 306 LFPDevgCVDPDECQkicgakvgcsniayPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRIRRRA 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 360 INNEKRI-ARLSSLSTLILGILllfaaWNPPSMIIWLNLLaFGGLQAV--FLWP-----LVLGLYWNKANRYGAIAGMIT 431
Cdd:cd11488 386 SEQELMVvGRVFILLLVVISIL-----WIPIIQTANSGQL-FDYIQAVtsYLSPpitavFILAIFWKRVNEPGAFWGLMV 459
|
.
gi 490365674 432 G 432
Cdd:cd11488 460 G 460
|
|
| SLC5sbd_YidK |
cd10328 |
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
10-439 |
8.44e-18 |
|
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271362 Cd Length: 472 Bit Score: 85.67 E-value: 8.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 10 VGYLLLVFLLSAYAYRKrEKGQFLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYG---IGWVLLSMIQLpa 86
Cdd:cd10328 2 LLFTALVALISWYKTRG-DDLSSSDGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGmsvMAWEVTAAIAL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 87 IWLSLGVLGKKFailarRYNAVTLNDMLYARYQSR--------FLVWFASLSL-LVAFVGAMTVQFIGGarlLETAAGIP 157
Cdd:cd10328 79 IILALVFLPRYL-----KGGITTIPEFLEERYDETtrrivsilFLLGYVVILLpIVLYSGALALNSLFD---VSELLGIS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 158 YEFGLLI----FGISIALYTAIGGFRASVLNDALQGLVMLLGTF-ILLFAIIY-----KAGGLDIAIQ----KLNAIDPA 223
Cdd:cd10328 151 YFQALWLlvwlIGIIGAIYAIFGGLKAVAVSDTINGVGLLIGGLlIPILGLIAlgdgsFLAGLDTLLTahpeKLNAIGGA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 224 lTSPHGADGILTGPFMAS--FWvlvcfgviGLPHTAV-RCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPD 300
Cdd:cd10328 231 -DSPVPFSTLFTGMLLVNlfYW--------CTNQAIIqRALAAKNLKEGQKGVLLAGFFKLLVPLILVLPGIIAFHLYGD 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 301 -LTVPDQVIPTLMVDVLPPFAAGIFLAAPMAAIMSTINAqLLQSSATL-VKDLYLNL-APHAinNEKRIARLSSLSTLIL 377
Cdd:cd10328 302 gLENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNS-ALNSAATLfSLDIYKPIiNKNA--TDKQLVKVGKIFGIVL 378
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490365674 378 GILLLFAA---WNPPSMIIWLnLLAFGGLQAVFLWPLVL-GLYWNKANRYGAIAGMITGATLYATL 439
Cdd:cd10328 379 ALISMIIApfiAYAPEGLFNY-LQQFNGFFSIPILAIVLvGFFTKRVPALAAKIALIFGVILYALL 443
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
6-439 |
2.08e-17 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 84.55 E-value: 2.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 6 IVPLVGYLLLVFLLSAYAYRkREKGQFLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYG---IGWVLLSMI 82
Cdd:PRK10484 4 ILSFLGFTLLVAVISWWKTR-KTDTSSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGmsvMAWEVTAAI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 83 QLpaIWLSLGVLGKKFailarRYNAVTLNDMLYARYQSRFLVwFASLSLLVAFVGAM--TVQFIGGARL-----LETAAG 155
Cdd:PRK10484 83 AL--IILALIFLPRYL-----KSGITTIPDFLEERYDKTTRR-IVSILFLIGYVVSFlpIVLYSGALALnslfhVSELLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 156 IPYEFGLLIFGISI----ALYTAIGGFRASVLNDALQGLVMLLGTF-ILLFAIIY-----KAGGLDIAIQ----KLNAID 221
Cdd:PRK10484 155 ISYGAAIWLLVWLIgiigAIYAVFGGLKAVAVSDTINGIGLLIGGLlVPVFGLIAlgdgsFMQGLEQLTTvhpeKLNSIG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 222 PAlTSPHGADGILTGPFMASFWVLVCFGVIglphtAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPD- 300
Cdd:PRK10484 235 GA-TDPVPFPTLFTGLILVNLFYWCTNQSI-----VQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHLYGDg 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 301 LTVPDQVIPTLMVDVLPPFAAGIFLAAPMAAIMSTINAqLLQSSATL-VKDLYLNLA-PHAinNEKRIARLSSLSTLILG 378
Cdd:PRK10484 309 LPNADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNG-FLNSASTLfSLDIYKPIInPNA--SEKQLVKVGKKFGFVLA 385
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490365674 379 ILllfaawnppSMIIwLNLLAFG---------GLQAVFLWPLV----LGLYWNKANRYGAIAGMITGATLYATL 439
Cdd:PRK10484 386 II---------SMIV-APLIANApqglysylqQLNGIYNVPILaiiiVGFFTKRVPALAAKVALGFGIILYIII 449
|
|
| SLC5sbd_SGLT2 |
cd11487 |
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ... |
6-432 |
4.05e-16 |
|
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212056 [Multi-domain] Cd Length: 583 Bit Score: 80.73 E-value: 4.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 6 IVPLVGYLLLVFLLSAYAYRKREKGQfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGwvlLSMIQLP 85
Cdd:cd11487 3 ISVIAAYFLLVIGVGLWSMCRTNRGT-VGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGIA---VAGFEWN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 86 AIWLSLgVLGKKFAILARRYNAVTLNDMLYARYQ-SRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLI 164
Cdd:cd11487 79 ALFVVL-LLGWLFVPVYLTAGVITMPQYLKKRFGgQRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 165 FGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAIDPALT------------------- 225
Cdd:cd11487 158 LLGITMIYTVTGGLAALMYTDTVQTFVIIGGACVLMGYAFHEVGGYSALFEKYLKAVPSLTvsedpavgnissscyrprp 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 226 -------SPHGAD----GILTGPFMASFWVLVCFGVIglphtAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALG 294
Cdd:cd11487 238 dsyhllrDPVTGDlpwpALILGLTIVSSWYWCSDQVI-----VQRCLAARSLTHVKAGCILCGYLKLLPMFLMVMPGMIS 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 295 RAIIPD-----------------LTVPDQVIPTLMVDVLPPFAAGIFLAAPMAAIMSTInAQLLQSSATL-VKDLYLNLA 356
Cdd:cd11487 313 RVLYPDevacvepsvclrvcgteVGCSNIAYPKLVVKLMPNGLRGLMLAVMLAALMSSL-ASIFNSSSTLfTMDIWTRLR 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 357 PHAINNE-KRIARLsslstLILGILLLFAAWNPPSMIIWLNLLaFGGLQAV--FLWP-----LVLGLYWNKANRYGAIAG 428
Cdd:cd11487 392 PQAGDKElLLVGRV-----WVVCIVAVSVAWIPVVQAAQGGQL-FDYIQSVssYLAPpiaavFFLALFVKRVNEPGAFWG 465
|
....
gi 490365674 429 MITG 432
Cdd:cd11487 466 LIGG 469
|
|
| SLC5sbd_SGLT6 |
cd11490 |
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ... |
6-435 |
8.57e-16 |
|
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271381 Cd Length: 602 Bit Score: 79.95 E-value: 8.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 6 IVPLVGYLLLVFLLSAYAYRKREKGQfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWV------LL 79
Cdd:cd11490 2 IVVLVLYFLFVLAVGLWSMWKTKRST-VKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVayewngLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 80 SMIQLPAIWLSLGVLGKkfailarrynAVTLNDMLYARYQS-RFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPY 158
Cdd:cd11490 81 MVLVLAWLFLPIYIASR----------VTTMPEYLKKRFGGkRIQIFLAVLYLFIYIFTKISVDMYAGAVFIQQALQWDL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 159 EFGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQKLNAIDPALTSPHGA-------- 230
Cdd:cd11490 151 YLAVVGLLGITALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVGGFEALLEKYFQAIPSIRSPNSTcgipreda 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 231 --------------DGILTGPFMASFWVLVCFGVIglphtAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRA 296
Cdd:cd11490 231 fhifrdpvtsdlpwPGVLLGMSIPSLWYWCTDQVI-----VQRSLAAKNLSHAKGGSLLAAYLKVLPLFMMVIPGMISRI 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 297 IIPDLT-----------------VPDQVIPTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHA 359
Cdd:cd11490 306 LFPDQVacadpevckeicgnpsgCSDIAYPKLVMELLPTGLRGLMMAVMLAALMSSLTSIFNSASTIFTMDLWRHIRPRA 385
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490365674 360 INNEKRI-ARLSSLSTLILGILL--LFAAWNPPSMIIWLNLLAfGGLQAVFLWPLVLGLYWNKANRYGAIAGMITGATL 435
Cdd:cd11490 386 SEWELMIvGRVFVLVLVVVSILWipLVQASQGGQLFIYIQSIS-SYLQPPVAVVFIAGCFWKRTNEKGAFWGLMVGLAV 463
|
|
| SLC5sbd_SGLT5 |
cd11489 |
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ... |
33-438 |
4.60e-15 |
|
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212058 Cd Length: 604 Bit Score: 77.67 E-value: 4.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 33 LNEYFLGNRSMGGFVLAMTITATYVSASSFIG--GPGAA-------YKYGIGWVLLSM--IQLPaIWLSLGVlgkkfail 101
Cdd:cd11489 31 VSGYFLAGRDMAWWPIGASLFASSEGSGLFIGlaGTGAAggiavagFEWNATYALLALawVFVP-VYISSGI-------- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 102 arrynaVTLNDMLYARYQ-SRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLIFGISIALYTAIGGFRA 180
Cdd:cd11489 102 ------VTMPEYLQRRFGgERIRMYLSVLSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVLMLVVTALYTIAGGLAA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 181 SVLNDALQGLVMLLGTFILLFAIIYKAGGL-DIAIQKLNAIdPALTSP--------HGADGILTGPFMASF-WVLVCFGV 250
Cdd:cd11489 176 VIYTDALQTLIMVIGAVILTIKAFNQIGGYsNLEEAYLQAV-PSKIIPnttchlprADAMHLFRDPVTGDLpWTGMTFGL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 251 IGLPH--------TAVRCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPD---LTVPDQVI----------- 308
Cdd:cd11489 255 TIMATwywctdqvIVQRSLSARSLSHAKGGSILASYLKMLPMGLIIMPGMISRALFPDdvaCVDPEECLrvcgaevgcsn 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 309 ---PTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAinNEKRIARLSSLSTLILGILllfaa 385
Cdd:cd11489 335 iayPKLVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPGA--SERELLLVGRLVTVILVGV----- 407
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490365674 386 wnppsMIIWLNLLAFGG-------LQAV--FLWP-----LVLGLYWNKANRYGAIAGMITGATLYAT 438
Cdd:cd11489 408 -----SVVWIPILQSSNsgqlyiyIQSVtsYLAPpvtavFVLAVFWRRANEQGAFWGLMAGLVVGLT 469
|
|
| Na_symport_lg |
TIGR03648 |
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of ... |
9-432 |
1.93e-14 |
|
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of transporters of the sodium:solute symporter superfamily, TC 2.A.21. Members of this strictly bacterial protein subfamily are found almost invariably immediately downstream from a member of family TIGR03647. Occasionally, the two genes are fused.
Pssm-ID: 274698 Cd Length: 552 Bit Score: 75.36 E-value: 1.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 9 LVGYLLLVFLLSAYAYRKREkgqfLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAY-------KYGIGW----V 77
Cdd:TIGR03648 4 FVGATFALYIGIGIWSRAGS----TSEFYVAGRGVPPVANGMATAADWMSAASFISMAGLIAflgydglAYLMGWtggyV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 78 LLSMIQLPAIwlslgvlgkkfailaRRYNAVTLNDMLYARYQSR-------FLVWFASLSLLVAFVGAMTVQFiggARLL 150
Cdd:TIGR03648 80 LLALLLAPYL---------------RKFGKYTVPDFIGDRYYSNtarlvavICAIFISFTYVAGQMRGVGVVF---SRFL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 151 EtaagIPYEFGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLDI-------------AIQKL 217
Cdd:TIGR03648 142 E----VDFETGVFIGMAIVFFYAVLGGMKGVTWTQVAQYIVLIVAYLVPAIFISLKLTGNPVpqlgygsalsgvyLLDKL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 218 NAIDPAL-----TSPHGADGILTgpfmasfWVLVCF----GVIGLPHTAVRCISYKDSKAMHRGIIIGTIVMALLMFGMH 288
Cdd:TIGR03648 218 DELEVDLgfaeyTEPFGSKSRIN-------VFALTLalmvGTAGLPHVIVRFYTVPKVRDARWSAGWALFFIALLYTTAP 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 289 FAGALGRAIIPD-----------------------------------LTVPDQVIPTLMVDV----------LPPFAAGI 323
Cdd:TIGR03648 291 AVAAFARYNLITtvngtpyaelpgwvanwektgllkfedkngdgilqYSGDAGNELTIDRDIivlatpeiagLPYWVIGL 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 324 FLAAPMAAIMSTINAQLLQSSATLVKDLYLN-LAPHAinNEKRIARLSSLSTLILGILLLFAAWNPPSMIIWLNLLAFGG 402
Cdd:TIGR03648 371 VAAGGLAAALSTAAGLLLVISSAISHDLYYRiINPNA--SEKQRLLVARIALVVAAVIAGYFGLNPPGFIAQVVAFAFGL 448
|
490 500 510
....*....|....*....|....*....|
gi 490365674 403 LQAVFLWPLVLGLYWNKANRYGAIAGMITG 432
Cdd:TIGR03648 449 AAASFFPALVLGIFWKRMNREGAIAGMLTG 478
|
|
| SLC5sbd_SMIT |
cd11491 |
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ... |
6-432 |
1.10e-12 |
|
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271382 Cd Length: 609 Bit Score: 70.28 E-value: 1.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 6 IVPLVGYLLLVFLLSAYAYRKREKGQfLNEYFLGNRSMGGFVLAMTITATYVSASSFIG--GPGAAYKYGIG-WVLLSMI 82
Cdd:cd11491 2 IAVVALYFILVMCIGIYAMWKSNRST-VSGYFLAGRSMTWLPVGASLFASNIGSEHFIGlaGSGAAAGFAVGaFEFNALI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 83 QLPAiwlslgvLGKKFAILARRYNAVTLNDMLYARYQS-RFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFG 161
Cdd:cd11491 81 LLQL-------LGWVFIPVYIRSGVYTLPEYLSKRFGGhRIQVYLAALSLILYIFTKISVNLYSGALFIQEALGWNLYVS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 162 LLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGLD-------IAIQKLNAIDPA----------- 223
Cdd:cd11491 154 IILLLGLTALLTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMMEIGGFEgvksrymLASPNVTSILLTynlsntnsccv 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 224 ---------LTSPHGAD----GILTGPFMASFWVLVCFGVIGLPHTAVRCISYKDSKAMHRGIIigtivMALLMFGMHFA 290
Cdd:cd11491 234 hpkkdafklLRDPTDEDvpwpGFILGQTPASIWYWCADQVIVQRVLAAKSLSHAQGATLMAGFI-----KLLPLFIIVIP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 291 GALGRAIIPDL---TVPDQVI--------------PTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYL 353
Cdd:cd11491 309 GMISRILFPDDiacINPEHCMqvcgsragcsniayPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTLDVYK 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 354 NLAPHAINNEKRI-ARLSSLSTLILGIlllfaAWNPPSMIIWLNLLaFGGLQAV--FLWP-----LVLGLYWNKANRYGA 425
Cdd:cd11491 389 LIRKKASSRELMIvGRIFVAVMVVISI-----AWIPVIQEMQGGQL-YLYIQEVaaYLTPpvaslYLLAIFWKRTTEQGA 462
|
....*..
gi 490365674 426 IAGMITG 432
Cdd:cd11491 463 FYGGMAG 469
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
9-439 |
2.05e-12 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 69.26 E-value: 2.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 9 LVGYLLLVFLLSAYAYRKREKGQ-FLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGwvLLSMIQLPAI 87
Cdd:cd10325 3 FIVYVILIIGLGLWVSREKKGGEkDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGLA--IASYEWMAAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 88 wlSLGVLGKKFAILARRYNAVTLNDMLYARYQSRFLVWFASLSLLV-AFVGAMTVQFIgGARLLETAAGIPYEFGLLIFG 166
Cdd:cd10325 81 --TLIIVAKFFLPIFLKNGIYTMPQFLEERYDGRVRTIMAVFWLLLyVFVNLTSVLYL-GALAIETITGIPLTYSIIGLA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 167 ISIALYTAIGGFRASVLNDALQGLVMLLG----TFILLFAIIYKAGGLDIAIQKLNAIDP----ALTSPHGADGILTGPF 238
Cdd:cd10325 158 LFAAAYSIYGGLKAVAWTDVIQVVFLVLGglvtTYIALSLLGGGEGVFAGFTLLAAEAPEhfhmILDKSNPEDAYKDLPG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 239 MASF----WVlVCFGVIGLPHTAV-RCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPDLT--------VPD 305
Cdd:cd10325 238 IAVLlgglWV-ANLSYWGFNQYIIqRALAAKSLSEAQKGIVFAAFLKLLIPFIVVIPGIAAYVLASNLLlpaatgieKPD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 306 QVIPTLMvDVLPPFAAGIFLAAPMAAIMSTInAQLLQSSATLVK-DLYLNLAPHAINNEK--RIARLSSLSTLILGILLl 382
Cdd:cd10325 317 QAYPWLL-RNLPTGLKGLVFAALTAAIVSSL-ASMLNSISTIFTmDIYKKYIPKKASEKQlvNVGRLAAVIALIIAALI- 393
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490365674 383 faAWnppsmiiwlNLLAFG---------------GLQAVFLwplvLGLYWNKANRYGAIAGMITGATLYATL 439
Cdd:cd10325 394 --AP---------PLLGLDqafqyiqeytgfispGILAIFL----LGLFWKRATSAGALVAAILSIVLSALF 450
|
|
| SLC5sbd_SMVT |
cd11504 |
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ... |
35-432 |
9.44e-11 |
|
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271394 [Multi-domain] Cd Length: 527 Bit Score: 63.74 E-value: 9.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 35 EYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIG-WVLLSmiqlpAIWLSLGVLGKKFAILARRYNAVTLNDM 113
Cdd:cd11504 35 EFLMADRKMGCLPVALSLLATFQSAVAILGGPSESYTFGTQyWFLGC-----SYFLGLLIPAHVFIPVFYRLELTSAYEY 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 114 LYARYqSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLIFGISIALYTAIGGFRASVLNDALQGLVML 193
Cdd:cd11504 110 LELRF-NKTVRICGTVTFIFQMVIYMGVVLYAPALALNAVTGFNLWISVLAMGVVCTFYTALGGLKAVIWTDVFQTVVMF 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 194 LGTFILLFAIIYKAGGLDIAIQKL---NAIDPALTSPHgadgiltgPFMA-SFWVLVCFGVI------GLPHTAV-RCIS 262
Cdd:cd11504 189 AGQLAVIIVGSIEAGGIARVWRVAaesDRIDGFNLSPD--------PTIRhTFWTLVVGGVFnmlalyGVNQAQVqRYLS 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 263 YKDSKAMHR-------GIIIGTIVMALLMFGMH-FAGALGRAIIPDLTVPDQVIPTLMVDVLP--PFAAGIFLAAPMAAI 332
Cdd:cd11504 261 SRTEKQAKRscylvfpGQQLSLCIGCLCGLVMFaRYHECDPLKNGIVARSDQLVPYFVMDVLDglPGLPGLFIACLFSGA 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 333 MSTINAQLLQSSATLVKDLylnLAPHAIN-NEKRIARLSSLSTLILGILLLFAAWNPPSM--IIWLNLLAFGGLQAVFLW 409
Cdd:cd11504 341 LSTISSAFNSLATVTMEDL---IVPKFPDmTEERATLLSKGLAVGYGLLCLLMAYLASTMgqVLQAANSIFGMIGGPLLG 417
|
410 420
....*....|....*....|...
gi 490365674 410 PLVLGLYWNKANRYGAIAGMITG 432
Cdd:cd11504 418 LFCLGMFFPCANSAGAVVGLLAG 440
|
|
| SLC5sbd_SMCT |
cd11505 |
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ... |
15-435 |
3.31e-10 |
|
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271395 Cd Length: 538 Bit Score: 62.21 E-value: 3.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 15 LVFLLSA-----YAYRKREKgQFLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSMIQLPAIWL 89
Cdd:cd11505 14 AMLFISAgigiyYAFAGGGQ-ATSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPSEVYRFGASFLIFAFAYLFVVLI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 90 SLGVlgkkFAILARRYNAVTLNDMLYARYqSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLIFGISI 169
Cdd:cd11505 93 SSEV----FLPVFYRLGITSTYEYLELRF-NKPVRLAGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVC 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 170 ALYTAIGGFRASVLNDALQGLVMLLGTFILLFAIIYKAGGldiaiqklnaIDPALTSPHGADGILTGPF------MASFW 243
Cdd:cd11505 168 TFYCTLGGLKAVVWTDVFQVGIMVAGFLSVIIQAVVHQGG----------IHNILNDSYNGSRLNFWDFdpnplrRHTFW 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 244 VLVC------FGVIGLPHTAV-RCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPD--------LTVPDQVI 308
Cdd:cd11505 238 TITVggtftwTGIYGVNQSQVqRYISCKTRFQAKLSLYFNLLGLWAILVCAVFSGLAMYSHYKDcdpwtakiVSAPDQLM 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 309 PTLMVDVLP--PFAAGIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAinNEKRIARLSSLSTLILGILLLFAAW 386
Cdd:cd11505 318 PYLVLDILAdyPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSL--SEKLSSWISKGLSLLYGAMCIGMAV 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 490365674 387 NPPSM--IIWLNLLAFGGLQAVFLWPLVLGLYWNKANRYGAIAGMITGATL 435
Cdd:cd11505 396 AASLMggLLQAALSIFGMVGGPLLGLFSLGILFPFVNSKGALGGLLTGFAI 446
|
|
| PRK12488 |
PRK12488 |
cation/acetate symporter; |
43-432 |
5.12e-10 |
|
cation/acetate symporter;
Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 61.74 E-value: 5.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 43 MGGFVLAMTITATYVSASSFIGGPGAAYKYGIGwVLLSMIQLPAIW-LSLGVLGKKFAILARrYNAVTLNDMLYARYQSR 121
Cdd:PRK12488 69 LTGMQNGLAIAGDMISAASFLGISAMMFMNGYD-GLLYALGVLAGWpIILFLIAERLRNLGK-YTFADVVSYRLAQGPVR 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 122 FLVWFASLSLLVAFvgaMTVQFIGGARLLETAAGIPYEFGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTFILLF 201
Cdd:PRK12488 147 LTAAFGTLTVVLMY---LVAQMVGAGKLIELLFGISYLYAVVIVGALMVLYVTFGGMLATTWVQIIKAVLLLSGTSFMAF 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 202 AII----YKAGGLDIAIQKLNAIDPALTSPhgaDGILTGPFMA-SFWVLVCFGVIGLPHTAVRCISYKDSKAMHRGIIIG 276
Cdd:PRK12488 224 MVLkhfgFSTEAMFASAVAVHAKGQAILAP---GGLLSNPIDAiSLGLGMMFGTAGLPHILMRFFTVSDAREARKSVLYA 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 277 TIVMA---LLMFGMHFAG--------ALGRAIIPDLTVPDQVIPTLMVDVLPPFAAGIFLAAPMAAIMSTINAQLLQSSA 345
Cdd:PRK12488 301 TGFIGyfyLLIIVVGFGAivmvgtepSYRDAGGKIIGGGNMVAVHLAQAVGGNLFLGFISAVAFATILAVVAGLALSGAS 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 346 TLVKDLYLNLAPHAINNEKRIARLSSLSTLILGIL-----LLFAAWNppsmIIWLNLLAFGGLQAVFLWPLVLGLYWNKA 420
Cdd:PRK12488 381 AVSHDLYACVIRKGQASEAQEMRVSKIATLGIGLLavvlgLMFESQN----IAFLSGLVLAIAASVNFPVLFLSMFWKGL 456
|
410
....*....|..
gi 490365674 421 NRYGAIAGMITG 432
Cdd:PRK12488 457 TTRGAVAGSYAG 468
|
|
| SLC5sbd_SMCT2 |
cd11520 |
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 ... |
22-435 |
4.11e-09 |
|
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. Human SMCT2 (hSMCT2) is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, it is expressed in the apical membrane of the proximal convoluted tubule, along the entire length of the tubule (in contrast to the high-affinity monocarboxylate transporter SMCT1, belonging to a different family, which is limited to the S3 segment of the tubule). SMCT2 may initiate lactate absorption in the early parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT2 is expressed exclusively in Muller cells. Nicotine transport by hSMCT2 is inhibited by several non-steroidal anti-inflammatory drugs. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212089 [Multi-domain] Cd Length: 529 Bit Score: 58.71 E-value: 4.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 22 YAYRKREKGQFlNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSMIQLPAIWLSlgvlGKKFAIL 101
Cdd:cd11520 26 FAIKERKKATS-KEFLVGGRQMSCGPVALSLTASFMSAVTVLGTPAEVYRFGASFVLFFIAYTFVIIFT----SELFLPV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 102 ARRYNAVTLNDMLYARYqSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLIFGISIALYTAIGGFRAS 181
Cdd:cd11520 101 FYRSGITSTYEYLELRF-NKPVRYAATLIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 182 VLNDALQGLVMLLGTFILLFAIIYKAGGLDiaiqklNAIDPALTSP--HGADGILTGPFMASFWVLVC------FGVIGL 253
Cdd:cd11520 180 VWTDAFQMVVMVVGFLTVLIQGSIHNGGFT------NVWETAYNGSrlNIFDFDVDPLRRHTFWTITVggtftwLGIYGV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 254 PHTAV-RCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPD--------LTVPDQVIPTLMVDVLP--PFAAG 322
Cdd:cd11520 254 NQSTIqRCISCKTEKHAKLALYLNLLGLWIILVCAVFSGLIMYSHYKDcdpwtsgfISAPDQLMPYFVMEIFStmPGLPG 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 323 IFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAinNEKRIARLSSLSTLILGILLLFAAWNPPSM--IIWLNLLAF 400
Cdd:cd11520 334 LFVACAFSGTLSTVAASINALATVTFEDFVKSCFPHL--SEKLSTWISKGLCILFGVMCTSMAVAASLMggVVQAALSIH 411
|
410 420 430
....*....|....*....|....*....|....*
gi 490365674 401 GGLQAVFLWPLVLGLYWNKANRYGAIAGMITGATL 435
Cdd:cd11520 412 GMCGGPMLGLFTLGIVFPFVNWKGALGGLLTGITL 446
|
|
| SLC5sbd_NIS |
cd11503 |
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ... |
34-440 |
5.14e-09 |
|
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271393 Cd Length: 535 Bit Score: 58.32 E-value: 5.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 34 NEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSMIQLpaiwLSLGVLGKKFAILARRYNAVTLNDM 113
Cdd:cd11503 31 DDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQL----LNSLMTAVLFMPVFYRLGITSTYQY 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 114 LYARYqSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLIFGISIALYTAIGGFRASVLNDALQGLVML 193
Cdd:cd11503 107 LEMRF-SRAVRLCGTLQFIVATMLYTGIVIYAPALILNQVTGLDIWASLFSTGIICTFYTTVGGMKAVIWTDVFQVVVML 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 194 LGTFILLFAIIYKAGGLDIAIQ--------KLNAIDPALTSPHgadgiltgpfmaSFWVLVCFGVI------GLPHTAV- 258
Cdd:cd11503 186 SGFWAVLIRGVILVGGPRRVLEiaqnhsriNFMDFDPDPRRRY------------TFWTFVVGGTLvwlsmyGVNQAQVq 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 259 RCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPD--------LTVPDQVIPTLMVDVLP--PFAAGIFLAAP 328
Cdd:cd11503 254 RYVACRTEKQAKLALLVNQVGLCLIVSSAATCGIVMFVYYSNcdplligrISAPDQYMPYLVLDIFEdlPGVPGLFLACA 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 329 MAAIMST----INAQLLQSSATLVKDLYLNLAPhainneKRIARLSSLSTLILGILLLfaawnppSMIIWLNLLAFGGLQ 404
Cdd:cd11503 334 YSGTLSTastsINAMAAVTVEDLIKPRLPTIAP------RKLVFISKGLSLIYGSACI-------TVAALSSLLGGGVLQ 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 490365674 405 AVF----------LWPLVLGLYWNKANRYGAIAGMITGATLYATLA 440
Cdd:cd11503 401 GSFtvmgvisgplLGAFALGMFLPACNTPGVFSGLAVGLALSLWVA 446
|
|
| actP |
PRK09395 |
cation/acetate symporter ActP; |
45-465 |
2.95e-07 |
|
cation/acetate symporter ActP;
Pssm-ID: 236495 Cd Length: 551 Bit Score: 52.67 E-value: 2.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 45 GFVLAMTITATYVSASSFIGGPGAAYK-------YGIGWVLLSMIQLPAIWLSLGVLGKkfailarrynaVTLNDMLYAR 117
Cdd:PRK09395 73 GFQNGLAIAGDYMSAASFLGISALVFTsgydgliYSIGFLVGWPIILFLIAERLRNLGK-----------YTFADVASYR 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 118 YQSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLIFGISIALYTAIGGFRASVLNDALQGLVMLLGTF 197
Cdd:PRK09395 142 LKQGPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVVLVGVLMMVYVLFGGMLATTWVQIIKAVLLLSGAT 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 198 ILLFAIIYKAG-GLDIAIQKLNAIDPALTSPHGADGILTGPFMA-SFWVLVCFGVIGLPHTAVRCISYKDSKAMHRGIII 275
Cdd:PRK09395 222 FMAFMVMKHVGfSFENLFSEAVAVHPKGLAIMGPGGLVKDPISAlSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFY 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 276 GTIVMA---LLMFGMHFAGALGRAIIPDLTVPDQVI--PTLMVDVLPPFAAG--IFL----AAPMAAIMSTINAQLLQSS 344
Cdd:PRK09395 302 ATGFIGyfyILTFIIGFGAIVLVGTNPEFKDAAGALigGNNMAAVHLANAVGgnLFLgfisAVAFATILAVVAGLTLAGA 381
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 345 ATLVKDLYLNLAPHAINNEKRIARLSSLSTLILGIL-----LLFAAWNPPSMIiwlnLLAFGGLQAVFLWPLVLGLYWNK 419
Cdd:PRK09395 382 SAVSHDLYANVIKKGKATERDELRVSKITTLVLGVVaiilgILFEKQNIAFMV----GLAFAIAASANFPVLLLSMYWKG 457
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 490365674 420 ANRYGAI----AGMITGATLYATLATFNIQIAGF-HPII----PALLLSLVAFLV 465
Cdd:PRK09395 458 LTTRGAViggwLGLISAVVLMILSPTVWVDILGHeKAIFpyeyPALFSMPLAFVG 512
|
|
| SLC5sbd_SMCT1 |
cd11519 |
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 ... |
22-432 |
7.14e-07 |
|
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271402 Cd Length: 542 Bit Score: 51.77 E-value: 7.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 22 YAYRKReKGQFLNEYFLGNRSMGGFVLAMTITATYVSASSFIGGPGAAYKYGIGWVLLSMIQLPAIWLSLGVlgkkFAIL 101
Cdd:cd11519 26 YAFAGG-GQQTSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFAFTYAIVVVISAEV----FLPV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 102 ARRYNAVTLNDMLYARYqSRFLVWFASLSLLVAFVGAMTVQFIGGARLLETAAGIPYEFGLLIFGISIALYTAIGGFRAS 181
Cdd:cd11519 101 FYRLGITSTYEYLELRF-NKCVRLIGTSLFIVQTALYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 182 VLNDALQGLVMLLGTFILLFAIIYKAGGLDIAIQ------KLNA--IDPALTSPHgadgiltgpfmaSFWVLVCFG---- 249
Cdd:cd11519 180 IWTDVFQVGIMVAGFVSVIIRAVVLQGGIGTILNdsyyggRLNFwdFDPNPLQRH------------TFWTIVIGGtftw 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 250 --VIGLPHTAV-RCISYKDSKAMHRGIIIGTIVMALLMFGMHFAGALGRAIIPD--------LTVPDQVIPTLMVDVLPP 318
Cdd:cd11519 248 tsIYGVNQSQVqRYISCKTRFQAKMSLYVNLVGLWAILSCAVLSGLAMYSIYKDcdpwtakdVSAPDQLMPYLVLDILAD 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365674 319 FAA--GIFLAAPMAAIMSTINAQLLQSSATLVKDLYLNLAPHAinNEKRIARLSSLSTLILGILLLFAAWNPPSM--IIW 394
Cdd:cd11519 328 YPGlpGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSL--SERQLSWISMGMSVFYGALCIGMAGLASLMgaLLQ 405
|
410 420 430
....*....|....*....|....*....|....*...
gi 490365674 395 LNLLAFGGLQAVFLWPLVLGLYWNKANRYGAIAGMITG 432
Cdd:cd11519 406 AALSIFGMVGGPLLGLFALGILFPFANSIGALVGLMSG 443
|
|
| |
