|
Name |
Accession |
Description |
Interval |
E-value |
| RpiR |
COG1737 |
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ... |
1-278 |
4.22e-67 |
|
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];
Pssm-ID: 441343 [Multi-domain] Cd Length: 286 Bit Score: 210.17 E-value: 4.22e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 1 MSTLTKKLENLRLQGKGTEQRLAHYLLENSDNIASMNAAELAQKAGVSSASVIRFSRQMGYGGYPEFKIDyLSEEKQQKS 80
Cdd:COG1737 4 AMSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLA-LAQELAEGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 81 SSDILYANLAKTDSTEQIIAKTGHLFTTAIQDSIALLDAATIDLLAEKMISAKRIVLFGVGASAIVASDIFHKLIRVNKN 160
Cdd:COG1737 83 SSYERLRRLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 161 T-LFSADLHAQLAYSANLSADDLAIAVTARGNTADINRMLKAAKQEGCITVALTRFGQDEATRLANYTLPYFYDEQHSQL 239
Cdd:COG1737 163 VvLLDGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRS 242
|
250 260 270
....*....|....*....|....*....|....*....
gi 490366480 240 GVITPQVLQMVAFDVLFFKYMTLAKGSAEKALLKGRQAV 278
Cdd:COG1737 243 SAFSSRVAQLALIDALAAAVAQRDGDKARERLERTEALL 281
|
|
| SIS_RpiR |
cd05013 |
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ... |
120-256 |
2.03e-30 |
|
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.
Pssm-ID: 240144 [Multi-domain] Cd Length: 139 Bit Score: 111.17 E-value: 2.03e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 120 ATIDLLAEKMISAKRIVLFGVGASAIVASDIFHKLIRVNKNTLFSADLHAQLAYSANLSADDLAIAVTARGNTADINRML 199
Cdd:cd05013 1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 490366480 200 KAAKQEGCITVALTRFGQDEATRLANYTLPYFYDEQHSQLGVITPQVLQMVAFDVLF 256
Cdd:cd05013 81 EIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALF 137
|
|
| PRK11337 |
PRK11337 |
MurR/RpiR family transcriptional regulator; |
18-278 |
7.82e-30 |
|
MurR/RpiR family transcriptional regulator;
Pssm-ID: 183089 [Multi-domain] Cd Length: 292 Bit Score: 114.09 E-value: 7.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 18 TEQRLAHYLLENSDNIASMNAAELAQKAGVSSASVIRFSRQMGYGGYPEFK---IDYLSEEKQQksssdiLYANLAKTDS 94
Cdd:PRK11337 29 LESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRsalEDYFSQSEQV------LHSELSFDDA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 95 TEQIIAKTGHLFTTAIQDSIALLDAATIDLLAEKMISAKRIVLFGVGASAIVASDIFHKLIRVNKNTLFSADLHAQLAYS 174
Cdd:PRK11337 103 PQDVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRCQAYDDAHIMLMSA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 175 ANLSADDLAIAVTARGNTADINRMLKAAKQEGCITVALTRFGQDEATRLANYTLPYFYDEQHSQLGVITPQVLQMVAFDV 254
Cdd:PRK11337 183 ALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLADYVICSTAQGSPLLGENAAARIAQLNILDA 262
|
250 260
....*....|....*....|....
gi 490366480 255 LFFKYMTLAKGSAEKALLKGRQAV 278
Cdd:PRK11337 263 FFVSVAQLNIEQAEINLQKTGAAV 286
|
|
| SIS |
pfam01380 |
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
128-256 |
3.90e-11 |
|
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.
Pssm-ID: 426230 [Multi-domain] Cd Length: 131 Bit Score: 59.23 E-value: 3.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 128 KMISAKRIVLFGVGASAIVASDIFHKLIRVNKNTLF----SADLHAQLAysaNLSADDLAIAVTARGNTADINRMLKAAK 203
Cdd:pfam01380 1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEvelaSELRHGVLA---LVDEDDLVIAISYSGETKDLLAAAELAK 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 490366480 204 QEGCITVALTRFGQDEATRLANYTLPYFYDEQHSQLGVITpQVLQMVAFDVLF 256
Cdd:pfam01380 78 ARGAKIIAITDSPGSPLAREADHVLYINAGPETGVASTKS-ITAQLAALDALA 129
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RpiR |
COG1737 |
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ... |
1-278 |
4.22e-67 |
|
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];
Pssm-ID: 441343 [Multi-domain] Cd Length: 286 Bit Score: 210.17 E-value: 4.22e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 1 MSTLTKKLENLRLQGKGTEQRLAHYLLENSDNIASMNAAELAQKAGVSSASVIRFSRQMGYGGYPEFKIDyLSEEKQQKS 80
Cdd:COG1737 4 AMSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLA-LAQELAEGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 81 SSDILYANLAKTDSTEQIIAKTGHLFTTAIQDSIALLDAATIDLLAEKMISAKRIVLFGVGASAIVASDIFHKLIRVNKN 160
Cdd:COG1737 83 SSYERLRRLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 161 T-LFSADLHAQLAYSANLSADDLAIAVTARGNTADINRMLKAAKQEGCITVALTRFGQDEATRLANYTLPYFYDEQHSQL 239
Cdd:COG1737 163 VvLLDGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRS 242
|
250 260 270
....*....|....*....|....*....|....*....
gi 490366480 240 GVITPQVLQMVAFDVLFFKYMTLAKGSAEKALLKGRQAV 278
Cdd:COG1737 243 SAFSSRVAQLALIDALAAAVAQRDGDKARERLERTEALL 281
|
|
| SIS_RpiR |
cd05013 |
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ... |
120-256 |
2.03e-30 |
|
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.
Pssm-ID: 240144 [Multi-domain] Cd Length: 139 Bit Score: 111.17 E-value: 2.03e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 120 ATIDLLAEKMISAKRIVLFGVGASAIVASDIFHKLIRVNKNTLFSADLHAQLAYSANLSADDLAIAVTARGNTADINRML 199
Cdd:cd05013 1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 490366480 200 KAAKQEGCITVALTRFGQDEATRLANYTLPYFYDEQHSQLGVITPQVLQMVAFDVLF 256
Cdd:cd05013 81 EIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALF 137
|
|
| PRK11337 |
PRK11337 |
MurR/RpiR family transcriptional regulator; |
18-278 |
7.82e-30 |
|
MurR/RpiR family transcriptional regulator;
Pssm-ID: 183089 [Multi-domain] Cd Length: 292 Bit Score: 114.09 E-value: 7.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 18 TEQRLAHYLLENSDNIASMNAAELAQKAGVSSASVIRFSRQMGYGGYPEFK---IDYLSEEKQQksssdiLYANLAKTDS 94
Cdd:PRK11337 29 LESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRsalEDYFSQSEQV------LHSELSFDDA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 95 TEQIIAKTGHLFTTAIQDSIALLDAATIDLLAEKMISAKRIVLFGVGASAIVASDIFHKLIRVNKNTLFSADLHAQLAYS 174
Cdd:PRK11337 103 PQDVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRCQAYDDAHIMLMSA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 175 ANLSADDLAIAVTARGNTADINRMLKAAKQEGCITVALTRFGQDEATRLANYTLPYFYDEQHSQLGVITPQVLQMVAFDV 254
Cdd:PRK11337 183 ALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLADYVICSTAQGSPLLGENAAARIAQLNILDA 262
|
250 260
....*....|....*....|....
gi 490366480 255 LFFKYMTLAKGSAEKALLKGRQAV 278
Cdd:PRK11337 263 FFVSVAQLNIEQAEINLQKTGAAV 286
|
|
| PRK11557 |
PRK11557 |
MurR/RpiR family transcriptional regulator; |
19-270 |
1.66e-29 |
|
MurR/RpiR family transcriptional regulator;
Pssm-ID: 183195 [Multi-domain] Cd Length: 278 Bit Score: 112.55 E-value: 1.66e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 19 EQRLAHYLLENSDNIASMNAAELAQKAGVSSASVIRFSRQMGYGGYPEFKIDyLSEE--KQQKSSSDILYANLAKTDSTE 96
Cdd:PRK11557 14 DRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLA-LSEAlaSQPEPPSVPVHNQIRGDDPLR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 97 QIIAKTghlfttaIQDSIALLDAaTIDLLAEKMI--------SAKRIVLFGVGASAIVASDIFHKLIRVNKNTLFSADLH 168
Cdd:PRK11557 93 LVGEKL-------IKENTAAMRA-TLDVNSEEKLhecvtmlrSARRIILTGIGASGLVAQNFAWKLMKIGINAVAERDMH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 169 AQLAYSANLSADDLAIAVTARGNTADINRMLKAAKQEGCITVALTRFGQDEATRLANYTLPYFYDEQHSQLGVITPQVLQ 248
Cdd:PRK11557 165 ALLATVQALSPDDLLLAISYSGERRELNLAADEALRVGAKVLAITGFTPNALQQRASHCLYTIAEEQATRSAAISSTHAQ 244
|
250 260
....*....|....*....|..
gi 490366480 249 MVAFDVLFfkyMTLAKGSAEKA 270
Cdd:PRK11557 245 GMLTDLLF---MALIQQDLERA 263
|
|
| PRK15482 |
PRK15482 |
HTH-type transcriptional regulator MurR; |
7-256 |
1.43e-28 |
|
HTH-type transcriptional regulator MurR;
Pssm-ID: 185379 [Multi-domain] Cd Length: 285 Bit Score: 110.56 E-value: 1.43e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 7 KLENLRLQGKGTEQRLAHYLLENSDNIASMNAAELAQKAGVSSASVIRFSRQMGYGGYPEFKI----DYLSEEKQQKSSS 82
Cdd:PRK15482 6 KIRNAESEFTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMaligEYSASREKTNATA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 83 DILYANLAKTDSTEQIIAKTGHLFTTAIQDSIALLDAATIDLLAEKMISAKRIVLFGVGASAIVASDIFHKLIRVNKNTL 162
Cdd:PRK15482 86 LHLHSSITSDDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 163 FSADLHAQLAYSANLSADDLAIAVTARGNTADINRMLKAAKQEGCITVALTRFGQDEATRLANYTLPYFYDEQHSQLGVI 242
Cdd:PRK15482 166 CEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEWRSSSM 245
|
250
....*....|....
gi 490366480 243 TPQVLQMVAFDVLF 256
Cdd:PRK15482 246 STRTAQNSVTDLLF 259
|
|
| PRK14101 |
PRK14101 |
bifunctional transcriptional regulator/glucokinase; |
18-255 |
6.00e-22 |
|
bifunctional transcriptional regulator/glucokinase;
Pssm-ID: 184507 [Multi-domain] Cd Length: 638 Bit Score: 95.37 E-value: 6.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 18 TEQRLAHYLLENSDNIASMNAAELAQKAGVSSASVIRFSRQMGYGGYPEFKIDY-------LSEEKQQKSSSDILYANLA 90
Cdd:PRK14101 357 AERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLatgltgtIPMSHSQVHLGDTATDFGA 436
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 91 KT--DSTEQIIAKTGHLFTTAIQDSIALLDaatidllaekmiSAKRIVLFGVGASAIVASDIFHKLIRVNKNTLFSADLH 168
Cdd:PRK14101 437 KVldNTVSAILQLREHLNFEHVEQAIDILN------------NARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGDLY 504
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 169 AQLAYSANLSADDLAIAVTARGNTADINRMLKAAKQEGCITVALTRFGQDEAtRLANYTLPYFYDE-QHSQLGVITpQVL 247
Cdd:PRK14101 505 MQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLA-KRATVALETDHIEmRESQLSMIS-RIL 582
|
....*...
gi 490366480 248 QMVAFDVL 255
Cdd:PRK14101 583 HLVMIDIL 590
|
|
| PRK11302 |
PRK11302 |
DNA-binding transcriptional regulator HexR; Provisional |
1-213 |
2.11e-19 |
|
DNA-binding transcriptional regulator HexR; Provisional
Pssm-ID: 183082 [Multi-domain] Cd Length: 284 Bit Score: 85.43 E-value: 2.11e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 1 MSTLTKKLENLRLQGKgTEQRLAHYLLENSDNIASMNAAELAQKAGVSSASVIRFSRQMGYGGYPEFKIdYLSeekqQKS 80
Cdd:PRK11302 1 MNMLEKIQSRLEHLSK-SERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKL-HLA----QSL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 81 SSDILYANLA--KTDSTEqiiAKTGHLFTTAI---QDSIALLDAATIDLLAEKMISAKRIVLFGVGASAIVASDIFHKLI 155
Cdd:PRK11302 75 ANGTPYVNRNveEDDSVE---AYTGKIFESAMaslDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFF 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 490366480 156 RVNKNTLFSADLHAQLAYSANLSADDLAIAVTARGNTADINRMLKAAKQEGCITVALT 213
Cdd:PRK11302 152 RFNVPVVYFDDIVMQRMSCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAIT 209
|
|
| SIS |
pfam01380 |
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
128-256 |
3.90e-11 |
|
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.
Pssm-ID: 426230 [Multi-domain] Cd Length: 131 Bit Score: 59.23 E-value: 3.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 128 KMISAKRIVLFGVGASAIVASDIFHKLIRVNKNTLF----SADLHAQLAysaNLSADDLAIAVTARGNTADINRMLKAAK 203
Cdd:pfam01380 1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEvelaSELRHGVLA---LVDEDDLVIAISYSGETKDLLAAAELAK 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 490366480 204 QEGCITVALTRFGQDEATRLANYTLPYFYDEQHSQLGVITpQVLQMVAFDVLF 256
Cdd:pfam01380 78 ARGAKIIAITDSPGSPLAREADHVLYINAGPETGVASTKS-ITAQLAALDALA 129
|
|
| HTH_6 |
pfam01418 |
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ... |
19-79 |
5.41e-11 |
|
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.
Pssm-ID: 334531 [Multi-domain] Cd Length: 77 Bit Score: 57.34 E-value: 5.41e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490366480 19 EQRLAHYLLENSDNIASMNAAELAQKAGVSSASVIRFSRQMGYGGYPEFKIdYLSEEKQQK 79
Cdd:pfam01418 18 ERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKL-ALAGELANS 77
|
|
| SIS_GmhA |
cd05006 |
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ... |
109-213 |
4.46e-07 |
|
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).
Pssm-ID: 240139 [Multi-domain] Cd Length: 177 Bit Score: 49.05 E-value: 4.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 109 AIQDSIALLDAATIDLLAEKMISA----KRIVLFGVGASAIVASDI---FHKLIRVNKNTL----FSADLHAQLAYS--- 174
Cdd:cd05006 6 QLKEALLELLAEAIEQAAQLLAEAllngGKILICGNGGSAADAQHFaaeLVKRFEKERPGLpaiaLTTDTSILTAIAndy 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 490366480 175 -----------ANLSADDLAIAVTARGNTADINRMLKAAKQEGCITVALT 213
Cdd:cd05006 86 gyeevfsrqveALGQPGDVLIGISTSGNSPNVLKALEAAKERGMKTIALT 135
|
|
| SIS_PHI |
cd05005 |
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ... |
110-213 |
2.18e-06 |
|
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.
Pssm-ID: 240138 [Multi-domain] Cd Length: 179 Bit Score: 46.80 E-value: 2.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 110 IQDSIALLDAATIDLLAEKMISAKRIVLFGVGASAIVASDIFHKLIRVNKNTLFSADlhaqlAYSANLSADDLAIAVTAR 189
Cdd:cd05005 11 IENVADKIDEEELDKLISAILNAKRIFVYGAGRSGLVAKAFAMRLMHLGLNVYVVGE-----TTTPAIGPGDLLIAISGS 85
|
90 100
....*....|....*....|....
gi 490366480 190 GNTADINRMLKAAKQEGCITVALT 213
Cdd:cd05005 86 GETSSVVNAAEKAKKAGAKVVLIT 109
|
|
| SIS_GlmS_GlmD_1 |
cd05008 |
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ... |
134-229 |
1.04e-05 |
|
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.
Pssm-ID: 240141 [Multi-domain] Cd Length: 126 Bit Score: 44.03 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 134 RIVLFGVGAS---AIVASDIFHKLIRVNKNTLFSADLHAqlaYSANLSADDLAIAVTARGNTADINRMLKAAKQEGCITV 210
Cdd:cd05008 1 RILIVGCGTSyhaALVAKYLLERLAGIPVEVEAASEFRY---RRPLLDEDTLVIAISQSGETADTLAALRLAKEKGAKTV 77
|
90
....*....|....*....
gi 490366480 211 ALTRFGQDEATRLANYTLP 229
Cdd:cd05008 78 AITNVVGSTLAREADYVLY 96
|
|
| AgaS |
COG2222 |
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ... |
109-224 |
1.23e-05 |
|
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441824 [Multi-domain] Cd Length: 336 Bit Score: 46.05 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 109 AIQDSIALLDAATIDLLAE-KMISAKRIVLFGVGASAIVAsDIFHKLIRVNKNTLFSAdLHA--QLAYSANLS-ADDLAI 184
Cdd:COG2222 10 AWRRALAALAAAIAALLARlRAKPPRRVVLVGAGSSDHAA-QAAAYLLERLLGIPVAA-LAPseLVVYPAYLKlEGTLVV 87
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 490366480 185 AVTARGNTADINRMLKAAKQEGCITVALTrfgQDEATRLA 224
Cdd:COG2222 88 AISRSGNSPEVVAALELAKARGARTLAIT---NNPDSPLA 124
|
|
| SIS_Kpsf |
cd05014 |
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ... |
134-255 |
3.89e-05 |
|
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.
Pssm-ID: 240145 [Multi-domain] Cd Length: 128 Bit Score: 42.53 E-value: 3.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 134 RIVLFGVGASAIVASDIFHKLIRVNKNTLFsadLHAQLAYSANL---SADDLAIAVTARGNTADINRMLKAAKQEGCITV 210
Cdd:cd05014 2 KVVVTGVGKSGHIARKIAATLSSTGTPAFF---LHPTEALHGDLgmvTPGDVVIAISNSGETDELLNLLPHLKRRGAPII 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 490366480 211 ALTrfGQDEAT--RLANYTLPYFYDEQHSQLGVI--TPQVLQMVAFDVL 255
Cdd:cd05014 79 AIT--GNPNSTlaKLSDVVLDLPVEEEACPLGLAptTSTTAMLALGDAL 125
|
|
| SIS_2 |
pfam13580 |
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
108-213 |
2.01e-04 |
|
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 433326 [Multi-domain] Cd Length: 138 Bit Score: 40.66 E-value: 2.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 108 TAIQDSIALLDAATIDLLAEKMISA----KRIVLFGVGASAIVASDIFHKLI-RVNKNTLFSAD--LHA----------- 169
Cdd:pfam13580 7 RALLERVVETQADAIEKAADLIAASlangGKVYAFGTGHSAAPAEELFARAGgLAGFEPILLPAlaLHTdasatistale 86
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 490366480 170 -------QLAYSANLSADDLAIAVTARGNTADINRMLKAAKQEGCITVALT 213
Cdd:pfam13580 87 rdegyarQILALYPGRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALT 137
|
|
| SIS_PGI_PMI_1 |
cd05017 |
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ... |
134-217 |
9.76e-04 |
|
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.
Pssm-ID: 240148 [Multi-domain] Cd Length: 119 Bit Score: 38.01 E-value: 9.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490366480 134 RIVLFGVGASAIVAsDIFHKL--IRVNKNTLFSADLHAqlaySANLSADDLAIAVTARGNTADINRMLKAAKQEGCITVA 211
Cdd:cd05017 1 NIVILGMGGSGIGG-DLLESLllDEAKIPVYVVKDYTL----PAFVDRKTLVIAVSYSGNTEETLSAVEQAKERGAKIVA 75
|
....*.
gi 490366480 212 LTRFGQ 217
Cdd:cd05017 76 ITSGGK 81
|
|
| |
