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Conserved domains on  [gi|490427217|ref|WP_004299378|]
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MULTISPECIES: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacteroides]

Protein Classification

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase( domain architecture ID 11415519)

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of glycerone phosphate and sn-glycerol-3-phosphate

CATH:  1.10.1040.10|3.40.50.720
EC:  1.1.1.-
Gene Ontology:  GO:0051287|GO:0047952|GO:0009331|GO:0046167|GO:0006072
SCOP:  4000111

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 6-328 5.57e-135

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 386.31  E-value: 5.57e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   6 KIAIMGGGSWATAIAKMCLAQEDSINWYMRRDDRIADFKRLGHNPAYLTGVKFDtRRITFSSNINDVVKESDTLIFVTPS 85
Cdd:COG0240    2 KIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLP-ENLRATSDLEEALAGADLVLLAVPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  86 PYLKAHLKK-LKTKIKDKFIITAIKGIVPDDNVIVSEYFTKEYGVPPeNIAVLAGPCHAEEVALERLSYLTIACPDKDKA 164
Cdd:COG0240   81 QALREVLEQlAPLLPPGAPVVSATKGIEPGTGLLMSEVIAEELPGAL-RIAVLSGPSFAEEVARGLPTAVVVASEDEEVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 165 RIFARRLGSSFIKTSVSDDVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLISNAIQEMNRFLNTVHPLNRNVDESVY 244
Cdd:COG0240  160 ERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 245 LGDLLVTGYSNFSRNRTFGTMIGKGYSVKSAQIEMEMIAEGYYGTKCIKEINKHHHVNMPILDAVYNILYERISPMIEIK 324
Cdd:COG0240  240 LGDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYEGKSPREAVE 319


                 ....
gi 490427217 325 LLTD 328
Cdd:COG0240  320 ALMA 323
 
Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 6-328 5.57e-135

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 386.31  E-value: 5.57e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   6 KIAIMGGGSWATAIAKMCLAQEDSINWYMRRDDRIADFKRLGHNPAYLTGVKFDtRRITFSSNINDVVKESDTLIFVTPS 85
Cdd:COG0240    2 KIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLP-ENLRATSDLEEALAGADLVLLAVPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  86 PYLKAHLKK-LKTKIKDKFIITAIKGIVPDDNVIVSEYFTKEYGVPPeNIAVLAGPCHAEEVALERLSYLTIACPDKDKA 164
Cdd:COG0240   81 QALREVLEQlAPLLPPGAPVVSATKGIEPGTGLLMSEVIAEELPGAL-RIAVLSGPSFAEEVARGLPTAVVVASEDEEVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 165 RIFARRLGSSFIKTSVSDDVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLISNAIQEMNRFLNTVHPLNRNVDESVY 244
Cdd:COG0240  160 ERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 245 LGDLLVTGYSNFSRNRTFGTMIGKGYSVKSAQIEMEMIAEGYYGTKCIKEINKHHHVNMPILDAVYNILYERISPMIEIK 324
Cdd:COG0240  240 LGDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYEGKSPREAVE 319


                 ....
gi 490427217 325 LLTD 328
Cdd:COG0240  320 ALMA 323
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
6-326 3.26e-84

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 257.31  E-value: 3.26e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   6 KIAIMGGGSWATAIAKMCLAQEDSINWYMRRDDRIADFKRLGHNPAYLTGVKFDTRrITFSSNINDVVKESDTLIFVTPS 85
Cdd:PRK00094   3 KIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDN-LRATTDLAEALADADLILVAVPS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  86 PY-------LKAHLKKLKTkikdkfIITAIKGIVPDDNVIVSEYFTKEYGvPPENIAVLAGPCHAEEVALERLSYLTIAC 158
Cdd:PRK00094  82 QAlrevlkqLKPLLPPDAP------IVWATKGIEPGTGKLLSEVLEEELP-DLAPIAVLSGPSFAKEVARGLPTAVVIAS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 159 PDKDKARIFARRLGSSFIKTSVSDDVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLISNAIQEMNRFlntvhplnrn 238
Cdd:PRK00094 155 TDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRL---------- 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 239 vdeSVYL-------------GDLLVTGYSNFSRNRTFGTMIGKGYSVKSAQIEMEMIAEGYYGTKCIKEINKHHHVNMPI 305
Cdd:PRK00094 225 ---GVALganpetflglaglGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPI 301

                        330       340
                 ....*....|....*....|.
gi 490427217 306 LDAVYNILYERISPMIEIKLL 326
Cdd:PRK00094 302 TEAVYAVLYEGKDPREAVEDL 322
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 183-324 8.01e-61

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 191.06  E-value: 8.01e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  183 DVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLISNAIQEMNRFLNTVHPLNRNVDESVYLGDLLVTGYSNFSRNRTF 262
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTCTSGLSRNRRF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490427217  263 GTMIGKGYSVKSAQIEMEMIAEGYYGTKCIKEINKHHHVNMPILDAVYNILYERISPMIEIK 324
Cdd:pfam07479  81 GEALGKGKSLEEAEKELGQVAEGVYTAKAVYELAKKLGVEMPIFEAVYRILYEGKSPEEALE 142
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 6-319 4.16e-42

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 149.03  E-value: 4.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217    6 KIAIMGGGSWATAIAKMCLAQ--------EDSINWYMRRDD----RIADFKRLGH-NPAYLTGVKFdTRRITFSSNINDV 72
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENaralpelfEESVRMWVFEEEiegrNLTEIINTTHeNVKYLPGIKL-PANLVAVPDLVEA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   73 VKESDTLIFVTPSPY-------LKAHLKKLKTKikdkfiITAIKGI-VPDDNV-IVSEYFTKEYGVPpenIAVLAGPCHA 143
Cdd:TIGR03376  80 AKGADILVFVIPHQFlegickqLKGHVKPNARA------ISCIKGLeVSKDGVkLLSDIIEEELGIP---CGVLSGANLA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  144 EEVALERLSYLTIACPDKDKARIFARRLGSSF----IKTSVSDDVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLIS 219
Cdd:TIGR03376 151 NEVAKEKFSETTVGYRDPADFDVDARVLKALFhrpyFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMR 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  220 NAIQEMNRFLNTVHP--LNRNVDESVYLGDLLVTGYSnfSRNRTFGTMIGKgySVKSAQ-IEMEMI----AEGYYGTKCI 292
Cdd:TIGR03376 231 RGLLEMIKFARMFFPtgEVTFTFESCGVADLITTCLG--GRNFKVGRAFAK--TGKSLEeLEKELLngqsLQGVATAKEV 306

                         330       340
                  ....*....|....*....|....*....
gi 490427217  293 KEINKHHHV--NMPILDAVYNILYERISP 319
Cdd:TIGR03376 307 HELLKNKNKddEFPLFEAVYQILYEGLPP 335
 
Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 6-328 5.57e-135

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 386.31  E-value: 5.57e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   6 KIAIMGGGSWATAIAKMCLAQEDSINWYMRRDDRIADFKRLGHNPAYLTGVKFDtRRITFSSNINDVVKESDTLIFVTPS 85
Cdd:COG0240    2 KIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLP-ENLRATSDLEEALAGADLVLLAVPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  86 PYLKAHLKK-LKTKIKDKFIITAIKGIVPDDNVIVSEYFTKEYGVPPeNIAVLAGPCHAEEVALERLSYLTIACPDKDKA 164
Cdd:COG0240   81 QALREVLEQlAPLLPPGAPVVSATKGIEPGTGLLMSEVIAEELPGAL-RIAVLSGPSFAEEVARGLPTAVVVASEDEEVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 165 RIFARRLGSSFIKTSVSDDVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLISNAIQEMNRFLNTVHPLNRNVDESVY 244
Cdd:COG0240  160 ERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 245 LGDLLVTGYSNFSRNRTFGTMIGKGYSVKSAQIEMEMIAEGYYGTKCIKEINKHHHVNMPILDAVYNILYERISPMIEIK 324
Cdd:COG0240  240 LGDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYEGKSPREAVE 319


                 ....
gi 490427217 325 LLTD 328
Cdd:COG0240  320 ALMA 323
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
6-326 3.26e-84

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 257.31  E-value: 3.26e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   6 KIAIMGGGSWATAIAKMCLAQEDSINWYMRRDDRIADFKRLGHNPAYLTGVKFDTRrITFSSNINDVVKESDTLIFVTPS 85
Cdd:PRK00094   3 KIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDN-LRATTDLAEALADADLILVAVPS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  86 PY-------LKAHLKKLKTkikdkfIITAIKGIVPDDNVIVSEYFTKEYGvPPENIAVLAGPCHAEEVALERLSYLTIAC 158
Cdd:PRK00094  82 QAlrevlkqLKPLLPPDAP------IVWATKGIEPGTGKLLSEVLEEELP-DLAPIAVLSGPSFAKEVARGLPTAVVIAS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 159 PDKDKARIFARRLGSSFIKTSVSDDVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLISNAIQEMNRFlntvhplnrn 238
Cdd:PRK00094 155 TDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRL---------- 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 239 vdeSVYL-------------GDLLVTGYSNFSRNRTFGTMIGKGYSVKSAQIEMEMIAEGYYGTKCIKEINKHHHVNMPI 305
Cdd:PRK00094 225 ---GVALganpetflglaglGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPI 301

                        330       340
                 ....*....|....*....|.
gi 490427217 306 LDAVYNILYERISPMIEIKLL 326
Cdd:PRK00094 302 TEAVYAVLYEGKDPREAVEDL 322
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 183-324 8.01e-61

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 191.06  E-value: 8.01e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  183 DVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLISNAIQEMNRFLNTVHPLNRNVDESVYLGDLLVTGYSNFSRNRTF 262
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTCTSGLSRNRRF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490427217  263 GTMIGKGYSVKSAQIEMEMIAEGYYGTKCIKEINKHHHVNMPILDAVYNILYERISPMIEIK 324
Cdd:pfam07479  81 GEALGKGKSLEEAEKELGQVAEGVYTAKAVYELAKKLGVEMPIFEAVYRILYEGKSPEEALE 142
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 5-326 1.77e-47

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 162.73  E-value: 1.77e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   5 GKIAIMGGGSWATAIAKMCLAQEDSINWYMRRDDRIADFKRLGHNPAYLTGVKFdTRRITFSSNINDVVKESDTLIFVTP 84
Cdd:PRK14618   5 MRVAVLGAGAWGTALAVLAASKGVPVRLWARRPEFAAALAAERENREYLPGVAL-PAELYPTADPEEALAGADFAVVAVP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  85 SpylKAHLKKLKTKIKDKFIITAIKGIVPDDNViVSEYFTKEYGVPPENIAVLAGPCHAEEVALERLSYLTIACPDKDKA 164
Cdd:PRK14618  84 S---KALRETLAGLPRALGYVSCAKGLAPDGGR-LSELARVLEFLTQARVAVLSGPNHAEEIARFLPAATVVASPEPGLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 165 RIFARRLGSSFIKTSVSDDVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLISNAIQEMNRFLNTVHPlnrnVDESVY 244
Cdd:PRK14618 160 RRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGVALGA----EEATFY 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 245 ----LGDLLVTGYSNFSRNRTFGTMIGKGYSVKSAQiEMEMIAEGYYGTKCIKEINKHHHVNMPILDAVYNILYERISPM 320
Cdd:PRK14618 236 glsgLGDLIATATSPHSRNRAAGEAIVRGVDREHLE-AGGKVVEGLYTVKALDAWAKAHGHDLPIVEAVARVARGGWDPL 314


                 ....*.
gi 490427217 321 IEIKLL 326
Cdd:PRK14618 315 AGLRSL 320
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 6-319 4.16e-42

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 149.03  E-value: 4.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217    6 KIAIMGGGSWATAIAKMCLAQ--------EDSINWYMRRDD----RIADFKRLGH-NPAYLTGVKFdTRRITFSSNINDV 72
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENaralpelfEESVRMWVFEEEiegrNLTEIINTTHeNVKYLPGIKL-PANLVAVPDLVEA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   73 VKESDTLIFVTPSPY-------LKAHLKKLKTKikdkfiITAIKGI-VPDDNV-IVSEYFTKEYGVPpenIAVLAGPCHA 143
Cdd:TIGR03376  80 AKGADILVFVIPHQFlegickqLKGHVKPNARA------ISCIKGLeVSKDGVkLLSDIIEEELGIP---CGVLSGANLA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  144 EEVALERLSYLTIACPDKDKARIFARRLGSSF----IKTSVSDDVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLIS 219
Cdd:TIGR03376 151 NEVAKEKFSETTVGYRDPADFDVDARVLKALFhrpyFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMR 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  220 NAIQEMNRFLNTVHP--LNRNVDESVYLGDLLVTGYSnfSRNRTFGTMIGKgySVKSAQ-IEMEMI----AEGYYGTKCI 292
Cdd:TIGR03376 231 RGLLEMIKFARMFFPtgEVTFTFESCGVADLITTCLG--GRNFKVGRAFAK--TGKSLEeLEKELLngqsLQGVATAKEV 306

                         330       340
                  ....*....|....*....|....*....
gi 490427217  293 KEINKHHHV--NMPILDAVYNILYERISP 319
Cdd:TIGR03376 307 HELLKNKNKddEFPLFEAVYQILYEGLPP 335
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-311 7.02e-39

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 140.30  E-value: 7.02e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   1 MKLPGKIAIMGGGSWATAIAKMCLAQEDSINWyMRRDDRIADFKRLGHNPAYL-TGVKF-DTRRITfsSNINDVVKESDT 78
Cdd:PRK12439   4 AKREPKVVVLGGGSWGTTVASICARRGPTLQW-VRSAETADDINDNHRNSRYLgNDVVLsDTLRAT--TDFAEAANCADV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  79 LIFVTPSPYLKAHLKKLKTKIKDKF-IITAIKGIVPDDNVIVSEYFtkEYGVPPENIAVLAGPCHAEEVALERLSYLTIA 157
Cdd:PRK12439  81 VVMGVPSHGFRGVLTELAKELRPWVpVVSLVKGLEQGTNMRMSQII--EEVLPGHPAGILAGPNIAREVAEGYAAAAVLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 158 CPDKDKARIFARRLGSSFIKTSVSDDVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLISNAIQEMNRFLNTVHPLNR 237
Cdd:PRK12439 159 MPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALREMTKLGVAMGGNPE 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490427217 238 NVDESVYLGDLLVTGYSNFSRNRTFGTMIGKGYSVKSAQIEMEMIAEGYYGTKCIKEINKHHHVNMPI---LDAVYN 311
Cdd:PRK12439 239 TFAGLAGMGDLIVTCTSQRSRNRHVGEQLGAGKPIDEIIASMNQVAEGVKAASVVMEFADEYGLNMPIareVDAVIN 315
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-327 6.22e-37

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 135.92  E-value: 6.22e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   1 MKLPGKIAIMGGGSWATAIAKMC-------LAQEDSINWYMRRD----DRIADFKRLGH-NPAYLTGVKFdTRRITFSSN 68
Cdd:PTZ00345   8 RCGPLKVSVIGSGNWGSAISKVVgentqrnYIFHNEVRMWVLEEivegEKLSDIINTKHeNVKYLPGIKL-PDNIVAVSD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  69 INDVVKESDTLIFVTPSPYLK---AHLKKLKTKIKDKFIITAIKGIVPDDN--VIVSEYFTKEYGVPpenIAVLAGPCHA 143
Cdd:PTZ00345  87 LKEAVEDADLLIFVIPHQFLEsvlSQIKENNNLKKHARAISLTKGIIVENGkpVLCSDVIEEELGIP---CCALSGANVA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 144 EEVALERLSYLTIACPDKDKARIFARRLGSSFIKTSVSDDVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLISNAIQ 223
Cdd:PTZ00345 164 NDVAREEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLE 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 224 EMNRFLNTVHP--LNRNVDESVYLGDLLVT--GYSNFSRNRTFGTMIGKgysvKS-AQIEMEMI-AEGYYGTKCIKEIN- 296
Cdd:PTZ00345 244 EMKLFGKIFFPnvMDETFFESCGLADLITTclGGRNVRCAAEFAKRNGK----KSwEEIEAELLnGQKLQGTVTLKEVYe 319

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 490427217 297 --KHHHVN--MPILDAVYNILYERISPMIEIKLLT 327
Cdd:PTZ00345 320 vlESHDLKkeFPLFTVTYKIAFEGADPSSLIDVLS 354
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 6-318 1.09e-35

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 131.49  E-value: 1.09e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   6 KIAIMGGGSWATAIAKMCLAQEDSINWYMRRDDRIADFKRLGHNPAYLTGVKFdTRRITFSSNINDVVKESDT-LIFVTP 84
Cdd:PRK14620   2 KISILGAGSFGTAIAIALSSKKISVNLWGRNHTTFESINTKRKNLKYLPTCHL-PDNISVKSAIDEVLSDNATcIILAVP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  85 SPYLKA--HLKKLKTKIKDKFIITAIKGIVPDDNVIVSEyFTKEygVPPEN-IAVLAGPCHAEEVAlERLSY-LTIACPD 160
Cdd:PRK14620  81 TQQLRTicQQLQDCHLKKNTPILICSKGIEKSSLKFPSE-IVNE--ILPNNpIAILSGPSFAKEIA-EKLPCsIVLAGQN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 161 KDKARIFARRLGSSFIKTSVSDDVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLISNAIQEMNRFLNTVhplNRNVD 240
Cdd:PRK14620 157 ETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKGMNEIKTLYSAK---NGSID 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 241 ESVY-----LGDLLVTGYSNFSRNRTFGTMIGKGYSVKSAQIEMEMIAEGYYGTKCIKEINKHHHVNMPILDAVYNILYE 315
Cdd:PRK14620 234 LNTLigpscLGDLILTCTTLHSRNMSFGFKIGNGFNINQILSEGKSVIEGFSTVKPLISLAKKLNIELPICESIYNLLYE 313


                 ...
gi 490427217 316 RIS 318
Cdd:PRK14620 314 NIS 316
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 6-164 2.53e-27

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 104.58  E-value: 2.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217    6 KIAIMGGGSWATAIAKMCLAQEDSINWYMRRDDRIADFKRLGHNPAYLTGVKFDTRrITFSSNINDVVKESDTLIFVTPS 85
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNGHEVRLWGRDEELIEEINTTHENVRYLPGIKLPEN-LKATTDLAEALKGADIIVIVVPS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   86 -----------PYLKAHLKklktkikdkfIITAIKGIVPDDNVIVSEYFTKEYGVPPEnIAVLAGPCHAEEVALERLSYL 154
Cdd:pfam01210  80 qalrevlkqlkGLLKPDAI----------LVSLSKGIEPGTLKLLSEVIEEELGIQPP-IAVLSGPSHAEEVAQGLPTAT 148

                         170
                  ....*....|
gi 490427217  155 TIACPDKDKA 164
Cdd:pfam01210 149 VIASKDEEAA 158
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 244-309 2.39e-24

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 93.72  E-value: 2.39e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490427217  244 YLGDLLVTGYSNFSRNRTFGTMIGKGYSVksAQIEMEMIAEGYYGTKCIKEINKH-HHVNMPILDAV 309
Cdd:pfam20618   2 GLGDLVLTCTSDLSRNRTFGLLLGKGMTL--AEAGNGQVAEGVRTAKAVAAILARaHNVEMPILEAV 66
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-326 5.21e-24

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 99.68  E-value: 5.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217   1 MKLPGKIAIMGGGSWATAIAKMCLAQEDSINWYMRRddriadfkrlghNPAYLTGVKFDTRRITFSSNINDVVKESDTLI 80
Cdd:PRK14619   1 TTQPKTIAILGAGAWGSTLAGLASANGHRVRVWSRR------------SGLSLAAVLADADVIVSAVSMKGVRPVAEQVQ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217  81 FVTPSPylkahlkklktkikDKFIITAIKGIVPDDNVIVSEYFTKEYgvPPENIAVLAGPCHAEEVALERLSYLTIACPD 160
Cdd:PRK14619  69 ALNLPP--------------ETIIVTATKGLDPETTRTPSQIWQAAF--PNHPVVVLSGPNLSKEIQQGLPAATVVASRD 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 161 KDKARIFARRLGSSFIKTSVSDDVAGIEYSSVLKNVYAIAAGICSGLKYGDNFQAVLISNAIQEMNRFLntvHPLNRNVd 240
Cdd:PRK14619 133 LAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMIRVG---THLGAQT- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427217 241 ESVY----LGDLLVTGYSNFSRNRTFGTMIGKGYSVKSAQIEMEMIAEGYYGTKCIKEINKHHHVNMPILDAVYNILYER 316
Cdd:PRK14619 209 ETFYglsgLGDLLATCTSPLSRNYQVGYGLAQGKSLEQILAELEGTAEGVNTANVLVQLAQQQNIAVPITEQVYRLLQGE 288

                        330
                 ....*....|
gi 490427217 317 ISPMIEIKLL 326
Cdd:PRK14619 289 ITPQQALEEL 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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