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Conserved domains on  [gi|490427235|ref|WP_004299396|]
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MULTISPECIES: ROK family protein [Bacteroides]

Protein Classification

ROK family protein( domain architecture ID 11449187)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase or may act as a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
Gene Ontology:  GO:0005524
PubMed:  20512568|17979299
SCOP:  3000092|4000330

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 4-286 1.50e-40

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


:

Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 145.04  E-value: 1.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235   4 HDERIVMTLDAGGTNFVFSAIQGCREIVEPICLP-AASDDLERCLSVLVEGFLEVEKRLPRL---PVAISFAFPGPADYE 79
Cdd:COG1940    2 PDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPtPAGAGPEAVLEAIAELIEELLAEAGISrgrILGIGIGVPGPVDPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  80 HGIIGDLPNFPAFRGgAALGPYLREQFGIPVFINNDGNLFAYGEALAGtlpevnkrlkeAGSSkvYKNLLGITLGTGFGA 159
Cdd:COG1940   82 TGVVLNAPNLPGWRG-VPLAELLEERLGLPVFVENDANAAALAEAWFG-----------AGRG--ADNVVYLTLGTGIGG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 160 GVVIDSRLLTGDNGCGGDVWIMRNKKYPEMIA-------EESVSIRAVRRVYQELTGKDAssLTPKDIYDIAEgtaEGDQ 232
Cdd:COG1940  148 GIVINGKLLRGANGNAGEIGHMPVDPDGPLCGcgnrgclETYASGPALLRRARELGGAEK--LTAEELFAAAR---AGDP 222

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 490427235 233 qAAVRSFNELGEMAGDAIIRALDIVD-GLVVIGGGVAGAAKYILPGIMNEMNRQI 286
Cdd:COG1940  223 -LALEVLDEAARYLGIGLANLINLLDpEVIVLGGGVSAAGDLLLEPIREALAKYA 276
 
Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 4-286 1.50e-40

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 145.04  E-value: 1.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235   4 HDERIVMTLDAGGTNFVFSAIQGCREIVEPICLP-AASDDLERCLSVLVEGFLEVEKRLPRL---PVAISFAFPGPADYE 79
Cdd:COG1940    2 PDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPtPAGAGPEAVLEAIAELIEELLAEAGISrgrILGIGIGVPGPVDPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  80 HGIIGDLPNFPAFRGgAALGPYLREQFGIPVFINNDGNLFAYGEALAGtlpevnkrlkeAGSSkvYKNLLGITLGTGFGA 159
Cdd:COG1940   82 TGVVLNAPNLPGWRG-VPLAELLEERLGLPVFVENDANAAALAEAWFG-----------AGRG--ADNVVYLTLGTGIGG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 160 GVVIDSRLLTGDNGCGGDVWIMRNKKYPEMIA-------EESVSIRAVRRVYQELTGKDAssLTPKDIYDIAEgtaEGDQ 232
Cdd:COG1940  148 GIVINGKLLRGANGNAGEIGHMPVDPDGPLCGcgnrgclETYASGPALLRRARELGGAEK--LTAEELFAAAR---AGDP 222

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 490427235 233 qAAVRSFNELGEMAGDAIIRALDIVD-GLVVIGGGVAGAAKYILPGIMNEMNRQI 286
Cdd:COG1940  223 -LALEVLDEAARYLGIGLANLINLLDpEVIVLGGGVSAAGDLLLEPIREALAKYA 276
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 12-176 2.26e-27

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 107.93  E-value: 2.26e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  12 LDAGGTNFVFSAIQGCREIVEPICLP-AASDDLERCLSVLVEGFLEVEKRLPRL--PVAISFAFPGPADYEHGIIGDLPN 88
Cdd:cd23763    3 IDIGGTKIRAALVDLDGEILARERVPtPAEEGPEAVLDRIAELIEELLAEAGVRerILGIGIGVPGPVDPETGIVLFAPN 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  89 FPAFRGgAALGPYLREQFGIPVFINNDGNLFAYGEALAGtlpevnkrlkeAGssKVYKNLLGITLGTGFGAGVVIDSRLL 168
Cdd:cd23763   83 LPWWKN-VPLRELLEERLGLPVVVENDANAAALGEAWFG-----------AG--RGVRNFVYITLGTGIGGGIIIDGKLY 148


                 ....*...
gi 490427235 169 TGDNGCGG 176
Cdd:cd23763  149 RGANGAAG 156
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 12-285 5.03e-24

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 100.11  E-value: 5.03e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235   12 LDAGGTNFVFSAIQGCREIVEPICLPAASDDLERCLSVLVEGFLEVEKRLPRLPVAISFAFPGPADYEHGIIGDLPNfPA 91
Cdd:pfam00480   3 IDIGGTKIAAALFDEEGEILARERVPTPTTTTEETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYITNTPN-IG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235   92 FRGGAALGPyLREQFGIPVFINNDGNLFAYGEALAGtlpevnkrlkeagSSKVYKNLLGITLGTGFGAGVVIDSRLLTGD 171
Cdd:pfam00480  82 WDNFDLVEK-LEERFNVPVFFENDANAAALAEAVFG-------------ASKDVQNVIYVTVGTGVGGGVISNGKLFTGR 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  172 NGCGGDVWIMR-----------NKKYPEMIAeesvSIRAVRRVYQElTGKDassLTPKDIYDIAEgtaEGDQQaAVRSFN 240
Cdd:pfam00480 148 NGVAGEIGHIQldpngpkcgcgNHGCLETIA----SGRALEKRYQQ-KGED---LEGKDIIVLAE---QGDEV-AEEAVE 215

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 490427235  241 ELGEMAGDAIIRALDIVD-GLVVIGGGVaGAAKYILPGIMNEMNRQ 285
Cdd:pfam00480 216 RLARYLAKAIANLINLFDpQAIVLGGGV-SNADGLLEAIRSLVKKY 260
PRK09698 PRK09698
D-allose kinase; Provisional
 8-267 1.83e-10

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 61.15  E-value: 1.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235   8 IVMTLDAGGTNFVFSAIQGCREIVEPICLPAAS----DDLERcLSVLVEGFLEVEKRLPRlpvAISFAFPGPADYEHGII 83
Cdd:PRK09698   5 VVLGIDMGGTHIRFCLVDAEGEILHCEKKRTAEviapDLVSG-LGEMIDEYLRRFNARCH---GIVMGFPALVSKDRRTV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  84 GDLPNFPAFRG-GAALGPYLREQFGIPVFINNDGNLFAYGEALAgtlpevNKRLKeagsskvyKNLLGITLGTGFGAGVV 162
Cdd:PRK09698  81 ISTPNLPLTALdLYDLADKLENTLNCPVFFSRDVNLQLLWDVKE------NNLTQ--------QLVLGAYLGTGMGFAVW 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 163 IDSRLLTGDNGCGGDV----WIMRNKKYP---EMIAEESVSIRAVRRVYQELTGKDASSltpkDIYDIAegtaeGDQQaA 235
Cdd:PRK09698 147 MNGAPWTGAHGVAGELghipLGDMTQHCGcgnPGCLETNCSGMALRRWYEQQPRDYPLS----DLFVHA-----GDHP-F 216

                        250       260       270
                 ....*....|....*....|....*....|...
gi 490427235 236 VRSFNELgemAGDAIIRALDIVD-GLVVIGGGV 267
Cdd:PRK09698 217 IQSLLEN---LARAIATSINLFDpDAIILGGGV 246
 
Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 4-286 1.50e-40

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 145.04  E-value: 1.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235   4 HDERIVMTLDAGGTNFVFSAIQGCREIVEPICLP-AASDDLERCLSVLVEGFLEVEKRLPRL---PVAISFAFPGPADYE 79
Cdd:COG1940    2 PDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPtPAGAGPEAVLEAIAELIEELLAEAGISrgrILGIGIGVPGPVDPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  80 HGIIGDLPNFPAFRGgAALGPYLREQFGIPVFINNDGNLFAYGEALAGtlpevnkrlkeAGSSkvYKNLLGITLGTGFGA 159
Cdd:COG1940   82 TGVVLNAPNLPGWRG-VPLAELLEERLGLPVFVENDANAAALAEAWFG-----------AGRG--ADNVVYLTLGTGIGG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 160 GVVIDSRLLTGDNGCGGDVWIMRNKKYPEMIA-------EESVSIRAVRRVYQELTGKDAssLTPKDIYDIAEgtaEGDQ 232
Cdd:COG1940  148 GIVINGKLLRGANGNAGEIGHMPVDPDGPLCGcgnrgclETYASGPALLRRARELGGAEK--LTAEELFAAAR---AGDP 222

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 490427235 233 qAAVRSFNELGEMAGDAIIRALDIVD-GLVVIGGGVAGAAKYILPGIMNEMNRQI 286
Cdd:COG1940  223 -LALEVLDEAARYLGIGLANLINLLDpEVIVLGGGVSAAGDLLLEPIREALAKYA 276
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 12-176 2.26e-27

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 107.93  E-value: 2.26e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  12 LDAGGTNFVFSAIQGCREIVEPICLP-AASDDLERCLSVLVEGFLEVEKRLPRL--PVAISFAFPGPADYEHGIIGDLPN 88
Cdd:cd23763    3 IDIGGTKIRAALVDLDGEILARERVPtPAEEGPEAVLDRIAELIEELLAEAGVRerILGIGIGVPGPVDPETGIVLFAPN 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  89 FPAFRGgAALGPYLREQFGIPVFINNDGNLFAYGEALAGtlpevnkrlkeAGssKVYKNLLGITLGTGFGAGVVIDSRLL 168
Cdd:cd23763   83 LPWWKN-VPLRELLEERLGLPVVVENDANAAALGEAWFG-----------AG--RGVRNFVYITLGTGIGGGIIIDGKLY 148


                 ....*...
gi 490427235 169 TGDNGCGG 176
Cdd:cd23763  149 RGANGAAG 156
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 38-296 7.29e-27

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 108.04  E-value: 7.29e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  38 AASDDLERCLSVLVEGFLEVEKRLPRLP---VAISFAFPGPADYEHGIIGDLPNFpafrG--GAALGPYLREQFGIPVFI 112
Cdd:cd24076   33 PASDDPDEVLAQLAALIREALAAAPDSPlgiLGIGVGVPGLVDSEDGVVLLAPNL----GwrDVPLRDLLEEALGVPVFV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 113 NNDGNLFAYGEALAGTLPEVNkrlkeagsskvykNLLGITLGTGFGAGVVIDSRLLTGDNGCGGDVWIMRnkkypemIA- 191
Cdd:cd24076  109 DNEANAAALAEKRFGAGRGVS-------------DLVYLSAGVGIGAGIILDGELYRGASGFAGEIGHMT-------VDp 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 192 -------------EESVSIRAVRRVYQELTGKDasslTPKDIYDIAEGTAEGDqQAAVRSFNELGEMAGDAIIRALDIVD 258
Cdd:cd24076  169 dgppcscgnrgcwETYASERALLRAAGRLGAGG----EPLSLAELVEAARAGD-PAALAALEEVGEYLGIGLANLVNTFN 243

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 490427235 259 -GLVVIGGGVAGAAKYILPGIMNEMNRQigTFAGASFPC 296
Cdd:cd24076  244 pELVVLGGALAPLGPWLLPPLRAEVARR--ALPAPARDV 280
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 12-285 5.03e-24

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 100.11  E-value: 5.03e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235   12 LDAGGTNFVFSAIQGCREIVEPICLPAASDDLERCLSVLVEGFLEVEKRLPRLPVAISFAFPGPADYEHGIIGDLPNfPA 91
Cdd:pfam00480   3 IDIGGTKIAAALFDEEGEILARERVPTPTTTTEETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYITNTPN-IG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235   92 FRGGAALGPyLREQFGIPVFINNDGNLFAYGEALAGtlpevnkrlkeagSSKVYKNLLGITLGTGFGAGVVIDSRLLTGD 171
Cdd:pfam00480  82 WDNFDLVEK-LEERFNVPVFFENDANAAALAEAVFG-------------ASKDVQNVIYVTVGTGVGGGVISNGKLFTGR 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  172 NGCGGDVWIMR-----------NKKYPEMIAeesvSIRAVRRVYQElTGKDassLTPKDIYDIAEgtaEGDQQaAVRSFN 240
Cdd:pfam00480 148 NGVAGEIGHIQldpngpkcgcgNHGCLETIA----SGRALEKRYQQ-KGED---LEGKDIIVLAE---QGDEV-AEEAVE 215

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 490427235  241 ELGEMAGDAIIRALDIVD-GLVVIGGGVaGAAKYILPGIMNEMNRQ 285
Cdd:pfam00480 216 RLARYLAKAIANLINLFDpQAIVLGGGV-SNADGLLEAIRSLVKKY 260
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 9-287 1.34e-23

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 98.78  E-value: 1.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235   9 VMTLDAGGTNFVFSAIQGCREIVEPICLPA-ASDDLERCLSVLVEGFLEVEKRLPrlPVAISFAFPGPADYEHG-IIGDL 86
Cdd:cd24068    2 ILGIDIGGTKIKYGLVDADGEILEKDSVPTpASKGGDAILERLLEIIAELKEKYD--IEGIGISSAGQVDPKTGeVIYAT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  87 PNFPAFRGgAALGPYLREQFGIPVFINNDGNLFAYGEalagtlpevnkrlKEAGSSKVYKNLLGITLGTGFGAGVVIDSR 166
Cdd:cd24068   80 DNLPGWTG-TNLKEELEERFGLPVAVENDVNCAALAE-------------KWLGAAKGLDDFLCLTLGTGIGGAIILDGR 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 167 LLTGDNGCGGDV--WIMRNKKYPEM-----IAEESVSIRAVRRVYQELTGKDAssLTPKDIYDIAEgtaEGDqQAAVRSF 239
Cdd:cd24068  146 LYRGANGSAGELghMVVDPGGRPCCcggkgCLEQYASGTALVRRVAEALGEPG--IDGREIFDLAD---AGD-PLAKEVV 219

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 490427235 240 NELGEMAGDAIIRALDIVD-GLVVIGGGVAGAAKYILPGIMNEMNRQIG 287
Cdd:cd24068  220 EEFAEDLATGLANLVHIFDpEVIVIGGGISAQGELFLEELREELRKLLM 268
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 40-286 1.78e-22

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 96.12  E-value: 1.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  40 SDDLERCLSVLVEGFLEVEKRLPRLpVAISFAFPGPADYEHGIIGDLPNFPAFRGgAALGPYLREQFGIPVFINNDGNLF 119
Cdd:cd24059   38 PEEVLEKLYELIDRLLEKENIKSKI-LGIGIGAPGPLDVEKGIILNPPNFPGWEN-IPLVELLEEKFGIPVYLDNDANAA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 120 AYGEalagtlpevnkrlKEAGSSKVYKNLLGITLGTGFGAGVVIDSRLLTGDNGCGGDVWIMR-----------NKKYPE 188
Cdd:cd24059  116 ALAE-------------KWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGEIGHTSidingprcscgNRGCLE 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 189 MIAeesvSIRAVRRVYQELTGKDassltPKDIYDIAEGTAEGDqQAAVRSFNELGEMAGDAIIRALDIVD-GLVVIGGGV 267
Cdd:cd24059  183 LYA----SIPAIEKKARSALGSG-----RSFQLDIVEALQKGD-PIADEVIEEAAKYLGIGLVNLINLLNpEAIIIGGEL 252

                        250
                 ....*....|....*....
gi 490427235 268 AGAAKYILPGIMNEMNRQI 286
Cdd:cd24059  253 IYLGERYLEPIEKEVNSRL 271
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 97-291 1.01e-19

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 88.50  E-value: 1.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  97 ALGPYLREQFGIPVFINNDGNLFAYGEalagtlpevnkrlKEAGSSKVYKNLLGITLGTGFGAGVVIDSRLLTGDNGCGG 176
Cdd:cd24071   92 ELKKILKEKFKIPVFIDNDVNSFALAE-------------LWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAG 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 177 DVWIMRNKK--YP---------EMIAEESVSIRAVRRVYQELTGKDASSLTPKDIYDIAEGTAEGDqQAAVRSFNELGEM 245
Cdd:cd24071  159 EIGHMTIQPdgRKcycgqkgclEAYASFEALVNEIKELTESYPLSLLKELEDFEIEKVREAAEEGD-SVATELFKKAGEY 237

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 490427235 246 AGDAIIRALDIVD-GLVVIGGGVAGAAKYILPGIMNEMNRQIGTFAG 291
Cdd:cd24071  238 LGIGIKNLINIFNpEAIIIGGEGLEFKDYFLPKIIEIAKENFFGKAG 284
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 12-267 1.95e-18

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 84.52  E-value: 1.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  12 LDAGGTNFVFSAI------QGCrEIVEPICLPAASDDLERcLSVLVEGFLEVEKRLPRlpvAISFAFPGPADYEHGIIGD 85
Cdd:cd24070    6 IDIGGTNIRIGLVdedgklLDF-EKVPSKDLLRAGDPVEV-LADLIREYIEEAGLKPA---AIVIGVPGTVDKDRRTVIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  86 LPNFPAFRGGAaLGPYLREQFGIPVFINNDGNLFAYGEALAGTLPEvnkrlkeagsskvYKNLLGITLGTGFGAGVVIDS 165
Cdd:cd24070   81 TPNIPGLDGVN-LADILENKLGIPVILERDVNLLLLYDMRAGNLDD-------------EGVVLGFYIGTGIGNAILING 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 166 RLLTGDNGCGGD---VWIMRNKKYPEM----IAEESVSIRAVRRVYQEltgkdasslTPKDIYDIAEGTAEGDqQAAVRS 238
Cdd:cd24070  147 KPLRGKNGVAGElghIPVYGNGKPCGCgntgCLETYASGRALEEIAEE---------HYPDTPILDIFVDHGD-EPELDE 216

                        250       260       270
                 ....*....|....*....|....*....|
gi 490427235 239 FNelgEMAGDAIIRALDIVD-GLVVIGGGV 267
Cdd:cd24070  217 FV---EDLALAIATEINILDpDAVILGGGV 243
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 67-278 2.12e-18

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 84.47  E-value: 2.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  67 AISFAFPGPADYEHGIIGDLPNFPAFRGgAALGPYLREQFGIPVFINNDGNLFAYGEalagtlpevnkrlKEAGSSKVYK 146
Cdd:cd24064   58 GIGIGSPGSIDRENGIVRFSPNFPDWRN-FPLVPLIEERTGIKVFLENDANAFALGE-------------WWFGNAKGSN 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 147 NLLGITLGTGFGAGVVIDSRLLTGDNGCG---GDVWIMRNKKY----PEMIAEESVSIRAVRRVYQELTGKDASSLtpkd 219
Cdd:cd24064  124 HIIGLTLGTGVGSGVICHGQLLTGYDGIAaelGHVIVEPNGPIcgcgNRGCVEAFASATAIIRYARESRKRYPDSL---- 199

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490427235 220 IYDIAEGTAEGDQQAAvRSFNELGEMAGDAIIRALDIVDG---------LVVIGGGVAGAAKYILPGI 278
Cdd:cd24064  200 AGESEKINAKHVFDAA-RKNDPLATMVFRRVVDALAIAIGgfvhifnpeIIIIGGGISRAGSFLLDPI 266
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 12-268 2.49e-17

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 81.51  E-value: 2.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  12 LDAGGTNFVFSAIQGCREIVEPICLPAASDDLERCLSVLVEGFLEVEKRLP-RLPVAISFafPGPADYEHGIIgDLPNFP 90
Cdd:cd24057    5 FDIGGTKIEFAVFDEALQLVWTKRVPTPTDDYAAFLAAIAELVAEADARFGvKGPVGIGI--PGVIDPEDGTL-ITANIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  91 AFRGgAALGPYLREQFGIPVFINNDGNLFAYGEAlagtlpevnkrlkEAGSSKVYKNLLGITLGTGFGAGVVIDSRLLTG 170
Cdd:cd24057   82 AAKG-RPLRADLSARLGRPVRIDNDANCFALSEA-------------WDGAGRGYPSVFGLILGTGVGGGLVVNGRLVGG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 171 DNGCGG---------DVWIMRnKKYP--------EMIAEESVSIRAVRRVYQELTGkdasslTPKDIYDIAEGTAEGDQQ 233
Cdd:cd24057  148 RSGIAGewghgplpaDALLLG-YDLPvlrcgcgqTGCLETYLSGRGLERLYAHLYG------EELDAPEIIAAWAAGDPQ 220

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 490427235 234 A--AVRSFNEL-GEMAGdAIIRALDIvdGLVVIGGGVA 268
Cdd:cd24057  221 AvaHVDRWLDLlAGCLA-NILTALDP--DVVVLGGGLS 255
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 59-284 3.68e-17

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 80.69  E-value: 3.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  59 KRLPRLPVAISFAFPGPADYEHGIIGDLPNFPAFRGgAALGPYLREQFGIPVFINNDGNLFAYGEAlagtlpevnkrlkE 138
Cdd:cd24152   48 KRYDEEIDGIAISAPGVIDPETGIIYGGGALPYLKG-FNLKEELEERCNLPVSIENDAKCAALAEL-------------W 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 139 AGSSKVYKNLLGITLGTGFGAGVVIDSRLLTGDNGCGGDVWIM--RNKKYPEMIAEESVSIRAVRRVYQELTGKDASSLt 216
Cdd:cd24152  114 LGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLltDDDDKDLLFFSGLASMFGLVKRYNKAKGLEPLDG- 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 217 pKDIYDIAegtAEGDqQAAVRSFNE-LGEMAGdAIIRALDIVD-GLVVIGGGVAgAAKYILPGIMNEMNR 284
Cdd:cd24152  193 -EEIFEKY---AKGD-EAAKKILDEyIRNLAK-LIYNIQYILDpEVIVIGGGIS-EQPLFIEDLKKEVNE 255
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 8-290 4.06e-16

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 77.75  E-value: 4.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235   8 IVMTLDAGGTNFVFSAIQGcREIVEPICLPAASDDLERCLSVLVEGFLEVEKRLPRlPVAISFAFPGPADYEHGIIGDLP 87
Cdd:cd24065    1 STIGLDLGGTKIAAGVVDG-GRILSRLVVPTPREGGEAVLDALARAVEALQAEAPG-VEAVGLGVPGPLDFRRGRVRFAP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  88 NFPAFRGgAALGPYLREQFGIPVFINNDGNLFAYGEALAGTlpevnkrlKEAGSSKVYknllgITLGTGFGAGVVIDSRL 167
Cdd:cd24065   79 NIPGLTD-FPIRRGLAERLGLPVVLENDANAAALAEHHYGA--------ARGTESSVY-----VTISTGIGGGLVLGGRV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 168 LTGDNGCGGDVWIMRNKKYPEMIA-------EESVSIRAVRRvyqeltgkDASSL--TPKDIYDIAEGTAEGDqQAAVRS 238
Cdd:cd24065  145 LRGRHGQAGEIGHTTVLPGGPMCGcglvgclEALASGRALAR--------DASFAygRPMSTAELFELAQQGE-PKALRI 215

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 490427235 239 FNELGEMAGDAIIRALDIVD-GLVVIGGGVAGAAKYILPGIMNEMNRQIGTFA 290
Cdd:cd24065  216 VEQAAAHLGIGLANLQKALDpEVFVLGGGVAQVGDYYLLPVQEAARRYTEGWH 268
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 47-286 1.06e-15

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 76.82  E-value: 1.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  47 LSVLVEGFLEVEKRLPRLPVAISFAFPGPADYEHGIIGDLPNFpaFRGGAALGPYLREQFGIPVFINNDGNLFAYGEALA 126
Cdd:cd24073   44 IAEAVAELLAQAGLSPDRLLGIGVGLPGLVDAETGICRWSPLL--GWRDVPLAELLEERLGLPVYVENDVNALALAEHWF 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 127 GtlpevnkrlkeAGssKVYKNLLGITLGTGFGAGVVIDSRLLTGDNGCGGDV--WIMrnkkypeMI------------AE 192
Cdd:cd24073  122 G-----------AG--RGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGEIghTTV-------DPdgppcrcgkrgcLE 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 193 ESVSIRAVRRVYQELtGKDASSLTPKDIYDIAEgtaEGDqQAAVRSFNELGEMAGDAIIRALDIVD-GLVVIGGGVAGAA 271
Cdd:cd24073  182 AYASDPAILRQAREA-GLRGEPLTIEDLLAAAR---AGD-PAARAILRRAGRALGLALANLVNLLDpELIIISGEGVRAG 256

                        250
                 ....*....|....*
gi 490427235 272 KYILPGIMNEMNRQI 286
Cdd:cd24073  257 DLLFEPMREALRAHV 271
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 66-278 3.19e-14

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 72.32  E-value: 3.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  66 VAISFAFPGPADYEHGIIGDLPNFpaFRGGAALGPYLREQFGIPVFINNDGNLFAYGEALAGtlpevnkrlkeAGssKVY 145
Cdd:cd24062   63 IGIGVGVPGPVDVETGTVEVAVNL--GWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKG-----------AG--QGA 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 146 KNLLGITLGTGFGAGVVIDSRLLTGDNGCGGDV-WIMRNKKYP-----------EMIAEESVSIRAVRRVYQELTG---- 209
Cdd:cd24062  128 KDLVFITLGTGVGGGVIANGKIVHGANGAAGEIgHITVNPEGGapcncgktgclETVASATGIVRIAREELEEGKGssal 207

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490427235 210 ---KDASSLTPKDIYDIAEgtaEGDqQAAVRSFNELGEMAGDAIIRALDIVD-GLVVIGGGVAGAAKYILPGI 278
Cdd:cd24062  208 rilALGGELTAKDVFEAAK---AGD-ELALAVVDTVARYLGLALANLANTLNpEKIVIGGGVSAAGEFLLSPV 276
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 9-280 2.03e-13

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 70.06  E-value: 2.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235   9 VMTLDAGGTNFVFSAIQGCREIVEPICLPAASDDLERCLSVLVEGFLEVEKRLPRLP--VAISFAFPGPADYEHGIIGDL 86
Cdd:cd24063    2 YVAVDIGGTWIRAGLVDEDGRILLKIRQPTPKTGDPGTVSEQVLGLIETLLSKAGKDsiEGIGVSSAGPLDLRKGTIVNS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  87 PNFPAFRGgaALGPYLREQFGIPVFINNDGNLFAYGEALAGtlpevnkrlkeagSSKVYKNLLGITLGTGFGAGVVIDSR 166
Cdd:cd24063   82 PNIKGKEI--PLVEPLKEEFNIPVALLNDAVAAALGEHLFG-------------AGRGTSNLVYITISTGIGGGVIVDGR 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 167 LLTGDN-------------------GCGG-DVWimrnkkypemiaEESVSIRAVRRVYQELTGKDASSL----------- 215
Cdd:cd24063  147 LLLGKNgnaaevghlvvdtesglkcGCGGyGHW------------EAFASGRGIPRFAREWAEGFSSRTslklrnpggeg 214

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490427235 216 -TPKDIYDIAegtAEGDqQAAVRSFNELGEMAGDAIIRALDIVD-GLVVIGGGVAGAAKYIL-PGIMN 280
Cdd:cd24063  215 iTAKEVFSAA---RKGD-PLALKIIEKLARYNGRGIANVINAYDpELIVIGGSVFNNNKDILdPLIEY 278
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 102-268 2.19e-13

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 69.93  E-value: 2.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 102 LREQFGIPVFINNDGNLFAYGEALAGtlpevnkrlkeAGssKVYKNLLGITLGTGFGAGVVIDSRLLTGDNGCGGDvW-- 179
Cdd:cd24066   91 LEARLGRPVRIENDANCFALSEATDG-----------AG--AGAGVVFGVILGTGVGGGIVVNGRVLTGANGIAGE-Wgh 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 180 ----IMRNKKYPEMIA--------EESVSIRAVRRVYQELTGKdasSLTPKDIYDiaegTAEGDQQAAVRSFNELGEMAG 247
Cdd:cd24066  157 nplpWPDEDELPGPPCycgkrgcvETFLSGPALERDYARLTGK---TLSAEEIVA----LARAGDAAAVATLDRFLDRLG 229

                        170       180
                 ....*....|....*....|..
gi 490427235 248 DAIIRALDIVD-GLVVIGGGVA 268
Cdd:cd24066  230 RALANVINILDpDVIVLGGGLS 251
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 13-278 2.45e-13

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 69.69  E-value: 2.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  13 DAGGTNFVFSAIQGCREI--VEPICLPAASDDLERCLSVLVEGFLEvekrlpRLPV-AISFAFPGPADYEHGIIGDLPNF 89
Cdd:cd24061    5 DIGGTKIAAGVVDEEGEIlaTERVPTPPTADGIVDAIVEAVEELRE------GHDVsAVGVAAAGFVDADRATVLFAPNI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  90 PaFRGgAALGPYLREQFGIPVFINNDGNLFAYGEALAGTLPEVNkrlkeagsskvykNLLGITLGTGFGAGVVIDSRLLT 169
Cdd:cd24061   79 A-WRN-EPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTD-------------DMVMITVGTGLGGGIVIGGKLLR 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 170 GDNGCGGDVWIMRnkKYPEMIA---------EESVSIRAVRRVYQELTGKD-------ASSLTPKDIY--DIAEGTAEGD 231
Cdd:cd24061  144 GAFGIAGEFGHIR--VVPDGLLcgcgsrgcwEQYASGRALVRYAKEAANATpegaavlLADGSVDGITgkHISEAARAGD 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 490427235 232 qQAAVRSFNELGEMAGDAIIRALDIVD-GLVVIGGGVAGAAKYILPGI 278
Cdd:cd24061  222 -PVALDALRELARWLGAGLASLAALLDpELFVIGGGVSDAGDLLLDPI 268
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 28-231 2.80e-13

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 69.65  E-value: 2.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  28 REIVE---PICLPAASDDLERCLSVLVEGFLEVEKRLPRLpVAISFAFPGPADYEHGIIGDLP-----NFPafrggaaLG 99
Cdd:cd24074   24 RLLAEeryPLPAKDNDPFLDRLLESISEFFSRHQKKLERL-TAIAITLPGIIDPESGIVHRLPfydikNLP-------LG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 100 PYLREQFGIPVFINNDGNlfaygealAGTLPEvnkrlKEAGSSKVYKNLLGITLGTGFGAGVVIDSRLLTGDNGCGGDVW 179
Cdd:cd24074   96 EALEQHTGLPVYVQHDIS--------AWTLAE-----RFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGELG 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490427235 180 IMRNKKYPEM-------IAEESVSIRAVRRVYQELTGK-DASSLTPKD--IYDIAEGTAEGD 231
Cdd:cd24074  163 HTQIDPYGKRcycgnhgCLETVASIPAILEQANQLLEQsPDSMLHGQPisIESLCQAALAGD 224
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 43-285 3.95e-13

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 69.32  E-value: 3.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  43 LERCLSVLVEGFLEVEKRLPRLPVAISFAFPGPADYEHGIIGDLPNFPAfrGGAALGPYLREQFGIPVFINNDGNLFAYG 122
Cdd:cd24075   40 LLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVVHYMPHIQV--KSWPIVEELEQRFNVPCFIGNDIRSLALA 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 123 EalagtlpevnkrlKEAGSSKVYKNLLGITLGTGFGAGVVIDSRLLTGDNGCGGDV-WIMRNKKYP----------EMIA 191
Cdd:cd24075  118 E-------------HYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEIgHIQIEPLGErchcgnfgclETVA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 192 EESVsirAVRRVYQELTGKDASSLTPKD--IYDIAEGTAEGDqQAAVRSFNELGEMAGDAIIRALDIVD-GLVVIGGGVA 268
Cdd:cd24075  185 SNAA---IEQRVKKLLKQGYASQLTLQDctIKDICQAALNGD-QLAQDVIKRAGRYLGKVIAILINLLNpQKIIIAGEIT 260

                        250
                 ....*....|....*..
gi 490427235 269 GAAKYILPGIMNEMNRQ 285
Cdd:cd24075  261 QADKVLLPVIKKCIQSQ 277
PRK09698 PRK09698
D-allose kinase; Provisional
 8-267 1.83e-10

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 61.15  E-value: 1.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235   8 IVMTLDAGGTNFVFSAIQGCREIVEPICLPAAS----DDLERcLSVLVEGFLEVEKRLPRlpvAISFAFPGPADYEHGII 83
Cdd:PRK09698   5 VVLGIDMGGTHIRFCLVDAEGEILHCEKKRTAEviapDLVSG-LGEMIDEYLRRFNARCH---GIVMGFPALVSKDRRTV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  84 GDLPNFPAFRG-GAALGPYLREQFGIPVFINNDGNLFAYGEALAgtlpevNKRLKeagsskvyKNLLGITLGTGFGAGVV 162
Cdd:PRK09698  81 ISTPNLPLTALdLYDLADKLENTLNCPVFFSRDVNLQLLWDVKE------NNLTQ--------QLVLGAYLGTGMGFAVW 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 163 IDSRLLTGDNGCGGDV----WIMRNKKYP---EMIAEESVSIRAVRRVYQELTGKDASSltpkDIYDIAegtaeGDQQaA 235
Cdd:PRK09698 147 MNGAPWTGAHGVAGELghipLGDMTQHCGcgnPGCLETNCSGMALRRWYEQQPRDYPLS----DLFVHA-----GDHP-F 216

                        250       260       270
                 ....*....|....*....|....*....|...
gi 490427235 236 VRSFNELgemAGDAIIRALDIVD-GLVVIGGGV 267
Cdd:PRK09698 217 IQSLLEN---LARAIATSINLFDpDAIILGGGV 246
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 12-170 2.15e-09

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 57.94  E-value: 2.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  12 LDAGGTNFVFSAIQGCREIVEPICLPaaSDDLERCLSVLVEGFLEVEKRLPRLPVAiSFafpGPAD-----YEHGIIGDL 86
Cdd:cd24067    4 IEAGGTKFVCAVGTGDGNIIERTEFP--TTTPEETLQAVIDFFREQEEPIDAIGIA-SF---GPIDlnptsPTYGYITTT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  87 PNfPAFRGGAALGPyLREQFGIPVFINNDGNLFAYGEALAGTLPEVnkrlkeagsskvyKNLLGITLGTGFGAGVVIDSR 166
Cdd:cd24067   78 PK-PGWRNFDILGA-LKRAFPVPVGFDTDVNAAALAEYRWGAAKGL-------------DSLAYITVGTGIGVGLVVNGK 142


                 ....
gi 490427235 167 LLTG 170
Cdd:cd24067  143 PVHG 146
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 47-178 5.46e-09

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 56.78  E-value: 5.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  47 LSVLVEGFLEVEKRLPRLP---VAISFAFpgpadyeHGIIG----------DLPNFPafrggaaLGPYLREQFGIPVFIN 113
Cdd:cd24077   41 LEILKSIIQELISQAPKTPyglVGIGIGI-------HGIVDeneiiftpyyDLEDID-------LKEKLEEKFNVPVYLE 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490427235 114 NDGNLFAYGEalagtlpevnkrlKEAGSSkvYKNLLGITLGTGFGAGVVIDSRLLTGDNGCGGDV 178
Cdd:cd24077  107 NEANLSALAE-------------RTFSED--YDNLISISIHSGIGAGIIINNQLYRGYNGFAGEI 156
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 12-269 2.00e-08

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 54.99  E-value: 2.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  12 LDAGGTNFVFSAIQGCREIVEPICLPAASDDLERCLSVLVEgflEVEKRLPRLPVA--ISFAFPGPADYEHGIIgDLPNF 89
Cdd:PRK13310   5 FDIGGTKIELGVFNEKLELQWEERVPTPRDSYDAFLDAVCE---LVAEADQRFGCKgsVGIGIPGMPETEDGTL-YAANV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  90 PAFRGGAALGPyLREQFGIPVFINNDGNLFAYGEALagtlPEVNKRlkeagsskvYKNLLGITLGTGFGAGVVIDSRLLT 169
Cdd:PRK13310  81 PAASGKPLRAD-LSARLGRDVRLDNDANCFALSEAW----DDEFTQ---------YPLVMGLILGTGVGGGLVFNGKPIS 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 170 GDNGCGG---------DVWIMRNKKYP--------EMIAEESVSIRAVRRVYQELTGKdassltPKDIYDIAEGTAEGDQ 232
Cdd:PRK13310 147 GRSYITGefghmrlpvDALTLLGWDAPlrrcgcgqKGCIENYLSGRGFEWLYQHYYGE------PLQAPEIIALYYQGDE 220

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 490427235 233 QAA--VRSFNELGEMAGDAIIRALDivDGLVVIGGGVAG 269
Cdd:PRK13310 221 QAVahVERYLDLLAICLGNILTIVD--PHLVVLGGGLSN 257
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 38-255 6.22e-08

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 53.57  E-value: 6.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  38 AASDDLERCLSVLVegfLEVEKRLPRLPVAISfafpGPADYEHGIIGDLPNFPafRGGAALGPYLREQFGIPVFINNDGN 117
Cdd:cd24072   40 ALIDEIIDCIDRLL---KLWKDRVKGIALAIQ----GLVDSHKGVSLWSPGAP--WRNIEIKYLLEERYGIPVFVENDCN 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 118 LFAYGEalagtlpevnkrlKEAGSSKVYKNLLGITLGTGFGAGVVIDSRLLTGDNGCGGDVWIMrnKKYPEMIA------ 191
Cdd:cd24072  111 MLALAE-------------KWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSGEIGHT--KVNPDGARcdcgrr 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490427235 192 ---EESVSIRAVRRVYQELTGKDASSLTPKDIY--DIAEGTAEGDQQAAvrsfnELGEMAGDAIIRALD 255
Cdd:cd24072  176 gclETVASNSALKRNARVTLKLGPVSADPEKLTmeQLIEALEEGEPIAT-----QIFDRAANAIGRSLA 239
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 92-274 8.46e-08

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 53.06  E-value: 8.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  92 FRGGAALGPYLREQFGIPVFINNDGNLFAYGEALAGTLPEVNkrlkeagsskvykNLLGITLGTGFGAGVVIDSRLLTGD 171
Cdd:cd24069   78 GLSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVG-------------NLVFITVSTGVGGGLVLNGQLLTGP 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 172 NGCGGDVWIMRNKKYP-----------EMIAeesvSIRAVRRVYQELTGKdasSLTPKDIYDIAEgtaEGDQQAAvrsfn 240
Cdd:cd24069  145 NGLAGHIGHTLADPPGpvcgcgrrgcvEAIA----SGTAIAAAASEILGE---PVDAKDVFERAR---SGDEEAA----- 209

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 490427235 241 ELGEMAGDAIIRAL-DIVDGL----VVIGGGVAGAAKYI 274
Cdd:cd24069  210 RLIDRAARALADLIaDLKATLdldcVVIGGSVGLAEGFL 248
ASKHA_NBD_GLK cd24008
nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7. ...
 13-268 1.02e-06

nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. Glucokinases are mainly found in invertebrates and microorganisms and highly specific for glucose. Glucokinases belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466858 [Multi-domain]  Cd Length: 313  Bit Score: 49.91  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  13 DAGGTNFVFSAIQGCREIVEPICLPA-ASDDLERcLSVLVEGFLEVEKRlpRLPVAISFAFPGPADyeHGIIGdLPNFP- 90
Cdd:cd24008    5 DIGGTNARLALADAGDGSGDLLFVRKyPSADFAS-LEDALAAFLAELGA--PRPKAACIAVAGPVD--GGRVR-LTNLDw 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  91 AFRGGAalgpyLREQFGI-PVFINNDgnLFAYGEALAGTLPEVNKRLKEAGSSKVYKNLLGITLGTGFGAGvvidsrLLT 169
Cdd:cd24008   79 SIDAAE-----LRKALGIgRVRLLND--FEAAAYGLPALGPEDLLVLYGGGGPLPGGPRAVLGPGTGLGVA------LLV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 170 GDNGCGGDVW---------------------IMRNKKYPEMIAEESVSIRAVRRVYQELTGKDASSLTPKDIYDIAEGTA 228
Cdd:cd24008  146 PDGDGGYVVLpsegghadfapvteeeaelleFLRKRFGRSVSYEDVLSGPGLENIYEFLAKLDGAEPPDLTAEEIAEAAL 225

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 490427235 229 EGDQ--QAAVRSFNE-LGEMAGDAIIRALdiVDGLVVIGGGVA 268
Cdd:cd24008  226 AGDPlaREALDLFARiLGRFAGNLALSFL--ATGGVYLAGGIA 266
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 84-273 1.43e-06

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 49.14  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  84 GDLPNFPafrggaaLGPYLREQFGIPVFINNDGNLFAYGEALAgtlpevnkrLKEAGSSKVYknllgITLGTGFGAGVVI 163
Cdd:PRK05082  81 GGLLHFP-------LVQTLEQLTDLPTIALNDAQAAAWAEYQA---------LPDDIRNMVF-----ITVSTGVGGGIVL 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 164 DSRLLTGDN------------------GCG--GDVwimrnkkypEMIAeesvSIRAVRRVYQ-ELTGKDassltPKDIYD 222
Cdd:PRK05082 140 NGKLLTGPGglaghightladphgpvcGCGrrGCV---------EAIA----SGRAIAAAAQgWLAGCD-----AKTIFE 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 490427235 223 IAegtAEGDQQAAV---RSFNELGEMAGDAIIrALDIvdGLVVIGGGVAGAAKY 273
Cdd:PRK05082 202 RA---GQGDEQAQAlinRSAQAIARLIADLKA-TLDC--QCVVLGGSVGLAEGY 249
PRK09557 PRK09557
fructokinase; Reviewed
 102-267 5.79e-06

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 47.33  E-value: 5.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 102 LREQFGIPVFINNDGNLFAYGEALAGTlpevnkrlkEAGSSKVYknllGITLGTGFGAGVVIDSRLLTGDNGCGGDvWim 181
Cdd:PRK09557  92 LSARLNREVRLANDANCLAVSEAVDGA---------AAGKQTVF----AVIIGTGCGAGVAINGRVHIGGNGIAGE-W-- 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235 182 RNKKYPEMIAEESVSIRAVR-------------------RVYQELTGKDASSLtpkdiyDIAEGTAEGDqQAAVRSFNEL 242
Cdd:PRK09557 156 GHNPLPWMDEDELRYRNEVPcycgkqgcietfisgtgfaTDYRRLSGKALKGS------EIIRLVEEGD-PVAELAFRRY 228

                        170       180
                 ....*....|....*....|....*.
gi 490427235 243 GEMAGDAIIRALDIVD-GLVVIGGGV 267
Cdd:PRK09557 229 EDRLAKSLAHVINILDpDVIVLGGGM 254
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 10-177 8.86e-06

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 47.03  E-value: 8.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  10 MTLDAGGTNFVFSAIQGCREIVEPICLPAASDDLER---CLSVLVEGFLEVEKRLPR-LPVAISFAfpGPADYEHGIIGD 85
Cdd:cd24060    3 LAVDLGGTNLRVAIVSMKGEIVKKYTQPNPKTYEERidlILQMCVEAASEAVKLNCRiLGVGISTG--GRVNPREGIVLH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490427235  86 LPNFPAFRGGAALGPYLREQFGIPVFINNDGNLFAYGEalagtlpevnkrlKEAGSSKVYKNLLGITLGTGFGAGVVIDS 165
Cdd:cd24060   81 STKLIQEWSSVDLRTPISDALHLPVWVDNDGNCAALAE-------------RKFGHGKGVENFVTVITGTGIGGGIILNH 147

                        170
                 ....*....|..
gi 490427235 166 RLLTGDNGCGGD 177
Cdd:cd24060  148 ELIHGSSFCAAE 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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