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Conserved domains on  [gi|490520790|ref|WP_004386254|]
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MULTISPECIES: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Cronobacter]

Protein Classification

4-hydroxy-3-methylbut-2-enyl diphosphate reductase( domain architecture ID 10011613)

4-hydroxy-3-methylbut-2-enyl diphosphate reductase converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) in the non-mevalonate pathway for isoprenoid synthesis

CATH:  3.40.1010.20
EC:  1.17.7.4
Gene Symbol:  ispH
Gene Ontology:  GO:0051745|GO:0051539|GO:0016114
PubMed:  20922726

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ispH PRK01045
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed
 1-301 0e+00

4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed


:

Pssm-ID: 234893  Cd Length: 298  Bit Score: 552.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAV 80
Cdd:PRK01045   1 MKILLANPRGFCAGVDRAIEIVERALEKYGAPIYVRHEIVHNRYVVERLEKKGAIFVEELDEVPDGAIVIFSAHGVSPAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  81 RNEAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYSnpeGGMYLVESPEDVWKITVKDENN 160
Cdd:PRK01045  81 REEAKERGLTVIDATCPLVTKVHKEVARMSREGYEIILIGHKGHPEVEGTMGQAP---GGVYLVESPEDVAKLEVKDPDK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 161 LSFMTQTTLSVDDTSEVIDALRSRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGK 240
Cdd:PRK01045 158 LALVTQTTLSVDDTAEIIAALKERFPEIQGPPKDDICYATQNRQEAVKELAPQADLVIVVGSKNSSNSNRLREVAEEAGA 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490520790 241 TAYLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLKALGGSDAHELTGREENIV 301
Cdd:PRK01045 238 PAYLIDDASEIDPEWFKGVKTVGVTAGASAPEWLVQEVIARLKELGATVVEEVEGREENIV 298
 
Name Accession Description Interval E-value
ispH PRK01045
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed
 1-301 0e+00

4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed


Pssm-ID: 234893  Cd Length: 298  Bit Score: 552.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAV 80
Cdd:PRK01045   1 MKILLANPRGFCAGVDRAIEIVERALEKYGAPIYVRHEIVHNRYVVERLEKKGAIFVEELDEVPDGAIVIFSAHGVSPAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  81 RNEAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYSnpeGGMYLVESPEDVWKITVKDENN 160
Cdd:PRK01045  81 REEAKERGLTVIDATCPLVTKVHKEVARMSREGYEIILIGHKGHPEVEGTMGQAP---GGVYLVESPEDVAKLEVKDPDK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 161 LSFMTQTTLSVDDTSEVIDALRSRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGK 240
Cdd:PRK01045 158 LALVTQTTLSVDDTAEIIAALKERFPEIQGPPKDDICYATQNRQEAVKELAPQADLVIVVGSKNSSNSNRLREVAEEAGA 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490520790 241 TAYLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLKALGGSDAHELTGREENIV 301
Cdd:PRK01045 238 PAYLIDDASEIDPEWFKGVKTVGVTAGASAPEWLVQEVIARLKELGATVVEEVEGREENIV 298
IspH COG0761
4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid transport and metabolism]; ...
 1-289 2.23e-176

4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid transport and metabolism]; 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440524  Cd Length: 289  Bit Score: 489.19  E-value: 2.23e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAV 80
Cdd:COG0761    2 MKILLAKPRGFCAGVDRAIEIVERALEKYGAPVYVLGEIVHNPQVVERLEAKGVVFVEELDEVPDGATVIFRAHGVSPEV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  81 RNEAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYsnpEGGMYLVESPEDVWKITVKDENN 160
Cdd:COG0761   82 REEAEERGLKVIDATCPLVTKVHKEVRRLAKEGYTIVIIGHKGHPEVEGTMGQA---PGKVVVVESPEDVEALPVRDPEK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 161 LSFMTQTTLSVDDTSEVIDALRSRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGK 240
Cdd:COG0761  159 LAVVSQTTLSVDDTAEIVEALKERFPEIRGPVKDTICYATQNRQDAVKELAKEVDLMLVVGGKNSSNTNRLVEVAKEAGP 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 490520790 241 TAYLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLKALGGSD 289
Cdd:COG0761  239 PAYLIETAEELDPEWLEGVKTVGITAGASTPEWLVEEVIDRLRELGPEE 287
LYTB pfam02401
LytB protein; The mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for ...
 7-283 5.77e-147

LytB protein; The mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis is essential in many eubacteria, plants, and the malaria parasite. The LytB gene is involved in the trunk line of the MEP pathway.


Pssm-ID: 460548  Cd Length: 270  Bit Score: 414.10  E-value: 5.77e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790    7 NPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEvPDGAILIFSAHGVSQAVRNEAKS 86
Cdd:pfam02401   1 KPAGFCFGVKRAIEIAEEALEEFGAPVYTLGPIVHNPQVVERLEEKGVVFVEDLDE-PEGAVVIIRAHGVSPEVYEEAKE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   87 RDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYsnpEGGMYLVESPEDVWKITVKDENnLSFMTQ 166
Cdd:pfam02401  80 RGLLIIDATCPLVTKVHKEVKRLAKEGYQIVIIGDKGHPEVIGTLGQA---PERAVVVEETEEVEKLLVPPEK-VAVVSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  167 TTLSVDDTSEVIDALRSRFPKIVGprKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGKTAYLID 246
Cdd:pfam02401 156 TTLSVDEFEEIVEALKKRFPELRV--FNTICYATQNRQDAVRELAKEVDLMIVVGGKNSSNTKRLVEICKEAGPPTYLIE 233

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 490520790  247 DANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLK 283
Cdd:pfam02401 234 TADELDPEWLKGVKTVGITAGASTPDWLIEEVIDKLE 270
lytB_ispH cd13944
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; The 4-hydroxy-3-methylbut-2-enyl ...
 3-282 2.48e-143

4-hydroxy-3-methylbut-2-enyl diphosphate reductase; The 4-hydroxy-3-methylbut-2-enyl diphosphate (HMBPP) reductase (called lytB or ispH) is the terminal enzyme of the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, one of the two metabolic routes for isoprenoid biosynthesis. The MEP pathway is essential in many eubacteria, plants, and the malaria parasite. LytB converts HMBPP into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).


Pssm-ID: 260116  Cd Length: 275  Bit Score: 404.87  E-value: 2.48e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRN 82
Cdd:cd13944    1 IILAKPAGFCFGVKRAIDIAEKALEEYGGPVYTLGPIIHNPQVVERLEKKGVKFVDDLDEVPEGGTVIIRAHGVSPEVYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  83 EAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYsnpEGGMYLVESPEDVWKITVKDENNLS 162
Cdd:cd13944   81 EAKERGLEVIDATCPLVKKVQKIVKKLAKEGYQVVIIGDKGHPEVIGILGYA---PGKAIVVESLEEAEKLPLYDLKKVG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 163 FMTQTTLSVDDTSEVIDALRSRFPKIVGPrkDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGKTA 242
Cdd:cd13944  158 VVSQTTQSVDEFEEIVEALKKRFPEIEVF--NTICYATQNRQEAARELAKEVDLMIVVGGKNSSNTKRLAEIAKEAGPPT 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 490520790 243 YLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRL 282
Cdd:cd13944  236 YLIETADELDPEWLKGVKKIGITAGASTPDWIIEEVIDRL 275
ispH_lytB TIGR00216
(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); The IspH ...
 3-285 1.49e-117

(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); The IspH protein (previously designated LytB) has now been recognized as the last enzyme in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Escherichia coli LytB protein had been found to regulate the activity of RelA (guanosine 3',5'-bispyrophosphate synthetase I), which in turn controls the level of a regulatory metabolite. It is involved in penicillin tolerance and the stringent response. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 272965  Cd Length: 282  Bit Score: 340.10  E-value: 1.49e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790    3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERG-AIFIEQISEVPDGAILIFSAHGVSQAVR 81
Cdd:TIGR00216   2 IILAKPRGFCFGVKRAIQMAEEALKEPGKPVYTLGEIVHNPQVVERLRERGvVFFLEDLDEVAAGDTVIFRAHGVPPEVR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   82 NEAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYSnpeGGMYLVESPEDVWKITVKDENNL 161
Cdd:TIGR00216  82 EELEKKGLEVIDATCPLVTKVHNAAKKYAKEGYHVILIGKKNHPEVIGTRGYAP---DGAILVETKEDLENFKFADEKRL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  162 SFMTQTTLSVDDTSEVIDALRSRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGKT 241
Cdd:TIGR00216 159 GVVSQTTLSQEDTKEIVAALKARYPQKEVPAFNTICYATQNRQDAVRELAPEVDLMIVIGGKNSSNTTRLFEIAEEHGGP 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 490520790  242 AYLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLKAL 285
Cdd:TIGR00216 239 SYLIETAEELPEEWLKGVKVVGITAGASTPDWIIEEVIRKLKEL 282
 
Name Accession Description Interval E-value
ispH PRK01045
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed
 1-301 0e+00

4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed


Pssm-ID: 234893  Cd Length: 298  Bit Score: 552.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAV 80
Cdd:PRK01045   1 MKILLANPRGFCAGVDRAIEIVERALEKYGAPIYVRHEIVHNRYVVERLEKKGAIFVEELDEVPDGAIVIFSAHGVSPAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  81 RNEAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYSnpeGGMYLVESPEDVWKITVKDENN 160
Cdd:PRK01045  81 REEAKERGLTVIDATCPLVTKVHKEVARMSREGYEIILIGHKGHPEVEGTMGQAP---GGVYLVESPEDVAKLEVKDPDK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 161 LSFMTQTTLSVDDTSEVIDALRSRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGK 240
Cdd:PRK01045 158 LALVTQTTLSVDDTAEIIAALKERFPEIQGPPKDDICYATQNRQEAVKELAPQADLVIVVGSKNSSNSNRLREVAEEAGA 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490520790 241 TAYLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLKALGGSDAHELTGREENIV 301
Cdd:PRK01045 238 PAYLIDDASEIDPEWFKGVKTVGVTAGASAPEWLVQEVIARLKELGATVVEEVEGREENIV 298
IspH COG0761
4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid transport and metabolism]; ...
 1-289 2.23e-176

4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid transport and metabolism]; 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440524  Cd Length: 289  Bit Score: 489.19  E-value: 2.23e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAV 80
Cdd:COG0761    2 MKILLAKPRGFCAGVDRAIEIVERALEKYGAPVYVLGEIVHNPQVVERLEAKGVVFVEELDEVPDGATVIFRAHGVSPEV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  81 RNEAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYsnpEGGMYLVESPEDVWKITVKDENN 160
Cdd:COG0761   82 REEAEERGLKVIDATCPLVTKVHKEVRRLAKEGYTIVIIGHKGHPEVEGTMGQA---PGKVVVVESPEDVEALPVRDPEK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 161 LSFMTQTTLSVDDTSEVIDALRSRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGK 240
Cdd:COG0761  159 LAVVSQTTLSVDDTAEIVEALKERFPEIRGPVKDTICYATQNRQDAVKELAKEVDLMLVVGGKNSSNTNRLVEVAKEAGP 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 490520790 241 TAYLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLKALGGSD 289
Cdd:COG0761  239 PAYLIETAEELDPEWLEGVKTVGITAGASTPEWLVEEVIDRLRELGPEE 287
LYTB pfam02401
LytB protein; The mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for ...
 7-283 5.77e-147

LytB protein; The mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis is essential in many eubacteria, plants, and the malaria parasite. The LytB gene is involved in the trunk line of the MEP pathway.


Pssm-ID: 460548  Cd Length: 270  Bit Score: 414.10  E-value: 5.77e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790    7 NPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEvPDGAILIFSAHGVSQAVRNEAKS 86
Cdd:pfam02401   1 KPAGFCFGVKRAIEIAEEALEEFGAPVYTLGPIVHNPQVVERLEEKGVVFVEDLDE-PEGAVVIIRAHGVSPEVYEEAKE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   87 RDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYsnpEGGMYLVESPEDVWKITVKDENnLSFMTQ 166
Cdd:pfam02401  80 RGLLIIDATCPLVTKVHKEVKRLAKEGYQIVIIGDKGHPEVIGTLGQA---PERAVVVEETEEVEKLLVPPEK-VAVVSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  167 TTLSVDDTSEVIDALRSRFPKIVGprKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGKTAYLID 246
Cdd:pfam02401 156 TTLSVDEFEEIVEALKKRFPELRV--FNTICYATQNRQDAVRELAKEVDLMIVVGGKNSSNTKRLVEICKEAGPPTYLIE 233

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 490520790  247 DANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLK 283
Cdd:pfam02401 234 TADELDPEWLKGVKTVGITAGASTPDWLIEEVIDKLE 270
lytB_ispH cd13944
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; The 4-hydroxy-3-methylbut-2-enyl ...
 3-282 2.48e-143

4-hydroxy-3-methylbut-2-enyl diphosphate reductase; The 4-hydroxy-3-methylbut-2-enyl diphosphate (HMBPP) reductase (called lytB or ispH) is the terminal enzyme of the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, one of the two metabolic routes for isoprenoid biosynthesis. The MEP pathway is essential in many eubacteria, plants, and the malaria parasite. LytB converts HMBPP into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).


Pssm-ID: 260116  Cd Length: 275  Bit Score: 404.87  E-value: 2.48e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRN 82
Cdd:cd13944    1 IILAKPAGFCFGVKRAIDIAEKALEEYGGPVYTLGPIIHNPQVVERLEKKGVKFVDDLDEVPEGGTVIIRAHGVSPEVYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  83 EAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYsnpEGGMYLVESPEDVWKITVKDENNLS 162
Cdd:cd13944   81 EAKERGLEVIDATCPLVKKVQKIVKKLAKEGYQVVIIGDKGHPEVIGILGYA---PGKAIVVESLEEAEKLPLYDLKKVG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 163 FMTQTTLSVDDTSEVIDALRSRFPKIVGPrkDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGKTA 242
Cdd:cd13944  158 VVSQTTQSVDEFEEIVEALKKRFPEIEVF--NTICYATQNRQEAARELAKEVDLMIVVGGKNSSNTKRLAEIAKEAGPPT 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 490520790 243 YLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRL 282
Cdd:cd13944  236 YLIETADELDPEWLKGVKKIGITAGASTPDWIIEEVIDRL 275
ispH_lytB TIGR00216
(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); The IspH ...
 3-285 1.49e-117

(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); The IspH protein (previously designated LytB) has now been recognized as the last enzyme in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Escherichia coli LytB protein had been found to regulate the activity of RelA (guanosine 3',5'-bispyrophosphate synthetase I), which in turn controls the level of a regulatory metabolite. It is involved in penicillin tolerance and the stringent response. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 272965  Cd Length: 282  Bit Score: 340.10  E-value: 1.49e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790    3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERG-AIFIEQISEVPDGAILIFSAHGVSQAVR 81
Cdd:TIGR00216   2 IILAKPRGFCFGVKRAIQMAEEALKEPGKPVYTLGEIVHNPQVVERLRERGvVFFLEDLDEVAAGDTVIFRAHGVPPEVR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   82 NEAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYSnpeGGMYLVESPEDVWKITVKDENNL 161
Cdd:TIGR00216  82 EELEKKGLEVIDATCPLVTKVHNAAKKYAKEGYHVILIGKKNHPEVIGTRGYAP---DGAILVETKEDLENFKFADEKRL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  162 SFMTQTTLSVDDTSEVIDALRSRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGKT 241
Cdd:TIGR00216 159 GVVSQTTLSQEDTKEIVAALKARYPQKEVPAFNTICYATQNRQDAVRELAPEVDLMIVIGGKNSSNTTRLFEIAEEHGGP 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 490520790  242 AYLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLKAL 285
Cdd:TIGR00216 239 SYLIETAEELPEEWLKGVKVVGITAGASTPDWIIEEVIRKLKEL 282
PRK00087 PRK00087
bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1;
1-292 9.53e-76

bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1;


Pssm-ID: 234623 [Multi-domain]  Cd Length: 647  Bit Score: 244.09  E-value: 9.53e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAV 80
Cdd:PRK00087   1 MEIILAKKAGFCFGVKRAVDTAIKTAEELKGKIYTLGPLIHNNQVVEKLKKKGIKPIEDIDELNEGDTIIIRSHGVPPEV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  81 RNEAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGqYSNPEGgmYLVESPEDVWKITVKDenN 160
Cdd:PRK00087  81 LEELKDKGLKVIDATCPFVKNIQKLAKKYYEEGYQIVIVGDKNHPEVIGING-WCNNSA--IIVEDGEEAEKLPFDK--K 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 161 LSFMTQTTLSVDDTSEVIDALRSRFPKIVgpRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGK 240
Cdd:PRK00087 156 ICVVSQTTEKQENFEKVLKELKKKGKEVK--VFNTICNATEVRQEAAEKLAKKVDVMIVVGGKNSSNTTKLYEICKSNCT 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 490520790 241 TAYLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLKALGGSDAHE 292
Cdd:PRK00087 234 NTIHIENAGELPEEWFKGVKIIGVTAGASTPDWIIEEVIKKMSELDNMEEVE 285
PRK12360 PRK12360
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional
 1-285 1.22e-60

4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional


Pssm-ID: 237075  Cd Length: 281  Bit Score: 194.95  E-value: 1.22e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   1 MQILLANPRGFCAGVDRAISIVENALAI-YGAPIYVRHEVVHNRYVVDSLRERG--AIFIEQISEVPDGAILIFSAHGVS 77
Cdd:PRK12360   1 MKILIAKNAGFCFGVKRAIDTAYDEIEKnDGKKIYTLGPLIHNNQVVSDLEEKGvkTIEESEIDSLKEGDVVIIRSHGVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  78 QAVRNEAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYSNPEggmYLVESPEDVWKITVKD 157
Cdd:PRK12360  81 KKVYKDLKDKGLEIIDATCPFVKKIQNIVEEYYNKGYSIIIVGDKNHPEVIGINGWCDNSA---YIVNSIEEVENIPFLD 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 158 enNLSFMTQTTLSVDDTSEVIDALRSRFPKIVgpRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQR 237
Cdd:PRK12360 158 --KACVVAQTTIIPELWEDILNVIKLKSKELV--FFNTICSATKKRQESAKELSKEVDVMIVIGGKHSSNTQKLVKICEK 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 490520790 238 MGKTAYLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLKAL 285
Cdd:PRK12360 234 NCPNTFHIETADELDLEMLKDYKIIGITAGASTPDWIIEEVIKKIKNL 281
PRK13371 PRK13371
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional
 2-290 1.07e-34

4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional


Pssm-ID: 237367  Cd Length: 387  Bit Score: 130.05  E-value: 1.07e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   2 QILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQI------SEVPDGAILIFSAH 74
Cdd:PRK13371  39 TIKLARAFGFCWGVERAVAMAYETRRHFpDERIWITNEIIHNPSVNQHLREMGVRFIPVEkgvkdfSVVTPGDVVILPAF 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  75 GVSqaVRNEAKSRDL--TVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQysnpeGGMYLV----ESPE 148
Cdd:PRK13371 119 GAT--VQEMQLLNEKgcHIVDTTCPWVSKVWNTVEKHKKKDFTSIIHGKYKHEETRATSSF-----AGTYLVvldlEEAQ 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 149 DVWKITVKDENNLSFMT-----------------------QTTLSVDDTSEVIDALRSRFPKIVGPRK--------DDIC 197
Cdd:PRK13371 192 YVADYILGGGDREEFLErfakayspgfdpdrdlervgvanQTTMLKSETEEIGKLFERTMLRKYGPANlnehflsfNTIC 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 198 YATTNRQEAVRALAEQ-ADVVLVVGSKNSSNSNRLAELAQRMGKTAYLIDDANDI-----------------QEAWVQNA 259
Cdd:PRK13371 272 DATQERQDAMFSLVEEpLDLMVVIGGYNSSNTTHLQEIAIERGIPSYHIDSPERIlsgnsiehkplgkelvvTENWLPEG 351

                        330       340       350
                 ....*....|....*....|....*....|..
gi 490520790 260 AC-VGVTAGASAPDVLVQNVITRLKALGGSDA 290
Cdd:PRK13371 352 PVtVGITSGASTPDKVVEDVIEKIFALKEDAR 383
PLN02821 PLN02821
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
 5-282 1.83e-28

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase


Pssm-ID: 215440  Cd Length: 460  Bit Score: 114.13  E-value: 1.83e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790   5 LANPRGFCAGVDRAISIV-ENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE------QISEVPDGAILIFSAHGVS 77
Cdd:PLN02821 110 LAKAYGFCWGVERAVQIAyEARKQFPDEKLWITNEIIHNPTVNKRLEEMNVQFIEveeggkDFSVVGEGDVVILPAFGAS 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790  78 QAVRNEAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTM---GQY---SNPEGGMY--------- 142
Cdd:PLN02821 190 VEEMQTLNDKNVQIVDTTCPWVSKVWNTVEKHKKKDYTSVIHGKYAHEETVATAsfaGKYiivKNMKEATYvcdyilggq 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 143 LVESPEDVWKITVKDENNLS-------------FMTQTTLSVDDTSEVIDALRSRFPKIVGPRK--------DDICYATT 201
Cdd:PLN02821 270 LDGSSGTKEEFLEKFKNAVSkgfdpdtdlvkvgIANQTTMLKGETEEIGKLLEKTMMQKYGVENvndhfmsfNTICDATQ 349

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490520790 202 NRQEAVRALAEQA-DVVLVVGSKNSSNSNRLAELAQRMGKTAYLIDDANDI-----------------QEAWV-QNAACV 262
Cdd:PLN02821 350 ERQDAMYKLVEEKlDLMLVVGGWNSSNTSHLQEIAEHKGIPSYWIDSEERIgpgntiahklnhgelveKENWLpEGPVTI 429

                        330       340
                 ....*....|....*....|
gi 490520790 263 GVTAGASAPDVLVQNVITRL 282
Cdd:PLN02821 430 GVTSGASTPDKVVEDVLDKV 449
PBP1_ABC_ligand_binding-like cd19982
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ...
 206-250 5.42e-03

type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.


Pssm-ID: 380637 [Multi-domain]  Cd Length: 302  Bit Score: 38.03  E-value: 5.42e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 490520790 206 AVRALAEQADVVLVVGSKNSSNSNRLAELAQRMgKTAYLIDDAND 250
Cdd:cd19982   58 AAEKLVSQDKVPLIVGGYSSGITLPVAAVAERQ-KIPLLVPTAAD 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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