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Conserved domains on  [gi|490522388|ref|WP_004387814|]
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MULTISPECIES: NlpC/P60 family protein [Cronobacter]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
18-154 5.99e-52

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 164.49  E-value: 5.99e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522388  18 SHRAPPPNARLSDSITVIAELNDQLNHWYGTPYRYGGMSRGGVDCSGFVMMTFRDrFSLMLPRETRQQAEIGTEIDKDEL 97
Cdd:COG0791   83 SSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYVWGGTSPSGFDCSGLVQYVYRQ-AGISLPRTSADQAAAGTPVSRSEL 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490522388  98 LPGDLVFFKTGSGQNGlHVGIYDTDNQFIHASTSR-GVMRSSLDNVYWRKKFWQARRI 154
Cdd:COG0791  162 QPGDLVFFRTGGGGIS-HVGIYLGNGKFIHASSSGkGVRISSLDSPYWKSRYVGARRV 218
YdgH_BhsA-like super family cl11507
YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around ...
 1-26 4.74e-03

YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.


The actual alignment was detected with superfamily member PRK14864:

Pssm-ID: 448290  Cd Length: 104  Bit Score: 34.63  E-value: 4.74e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 490522388   1 MRLWIFLVATLLLAGCSS-----HRAPPPNA 26
Cdd:PRK14864   5 MRRFASLLLTLLLSACSAlqgtpQPAPPPAD 35
 
Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
18-154 5.99e-52

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 164.49  E-value: 5.99e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522388  18 SHRAPPPNARLSDSITVIAELNDQLNHWYGTPYRYGGMSRGGVDCSGFVMMTFRDrFSLMLPRETRQQAEIGTEIDKDEL 97
Cdd:COG0791   83 SSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYVWGGTSPSGFDCSGLVQYVYRQ-AGISLPRTSADQAAAGTPVSRSEL 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490522388  98 LPGDLVFFKTGSGQNGlHVGIYDTDNQFIHASTSR-GVMRSSLDNVYWRKKFWQARRI 154
Cdd:COG0791  162 QPGDLVFFRTGGGGIS-HVGIYLGNGKFIHASSSGkGVRISSLDSPYWKSRYVGARRV 218
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
34-154 2.19e-50

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 159.55  E-value: 2.19e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522388  34 VIAELNDQLNHWYGTPYRYGGMSRGGVDCSGFVMMTFRDRFSLMLPRETRQQAEIGTEIDKDELLPGDLVFFKTGSgqNG 113
Cdd:PRK10838  66 VKSRIMDQYADWKGVRYRLGGSTKKGIDCSAFVQRTFREQFGLELPRSTYEQQEMGKSVSRSKLRTGDLVLFRAGS--TG 143

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 490522388 114 LHVGIYDTDNQFIHASTSRGVMRSSLDNVYWRKKFWQARRI 154
Cdd:PRK10838 144 RHVGIYIGNNQFVHASTSSGVIISSMNEPYWKKRYNEARRV 184
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 47-153 7.21e-43

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 137.41  E-value: 7.21e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522388   47 GTPYRYGGMSRGGVDCSGFVMMTFRdRFSLMLPRETRQQAEIGTE-IDKDELLPGDLVFFKTGSGQNglHVGIYDTDNQF 125
Cdd:pfam00877   1 GVPYRWGGGSPSGFDCSGLVRYAFA-KVGIELPRSSGQQYNAGKKtIPKSEPQRGDLVFFGTGKGIS--HVGIYLGNGQM 77

                          90       100
                  ....*....|....*....|....*...
gi 490522388  126 IHASTSRGVMRSSLDNVYWRKKFWQARR 153
Cdd:pfam00877  78 LHASTGGGVSISSLNGGYWQKRLVGVRR 105
phage_NlpC_fam TIGR02219
putative phage cell wall peptidase, NlpC/P60 family; Members of this family show sequence ...
 45-147 3.60e-09

putative phage cell wall peptidase, NlpC/P60 family; Members of this family show sequence similarity to members of the NlpC/P60 family described by pfam00877 and by Anantharaman and Aravind (). The NlpC/P60 family includes a number of characterized bacterial cell wall hydrolases. Members of this related family are all found in prophage regions of bacterial genomes. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 131274  Cd Length: 134  Bit Score: 51.79  E-value: 3.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522388   45 WYGTPYRYGGMSRG-GVDCSGFVMMTFRDRFSL---MLPRETRQQAEIGTE-------------IDKDELLPGDLVFFKT 107
Cdd:TIGR02219   8 WIGTPYRHQASTLGvGCDCLGLVRGVWRALYGEepeAPPPYAPDWAEAGGGetlaeaalrhlvpVPCDAAQPGDVLVFRW 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 490522388  108 GSGQNGLHVGIYDTDNQFIHASTSRGVMRSSLDNvYWRKK 147
Cdd:TIGR02219  88 RPGAAAKHAAIAASPTRFIHAYDGAAVVESALVP-WWRRR 126
PRK14864 PRK14864
biofilm peroxide resistance protein BsmA;
1-26 4.74e-03

biofilm peroxide resistance protein BsmA;


Pssm-ID: 184866  Cd Length: 104  Bit Score: 34.63  E-value: 4.74e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 490522388   1 MRLWIFLVATLLLAGCSS-----HRAPPPNA 26
Cdd:PRK14864   5 MRRFASLLLTLLLSACSAlqgtpQPAPPPAD 35
MliC COG3895
Membrane-bound inhibitor of C-type lysozyme [Cell wall/membrane/envelope biogenesis];
1-26 7.15e-03

Membrane-bound inhibitor of C-type lysozyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443102  Cd Length: 108  Bit Score: 34.26  E-value: 7.15e-03
                         10        20
                 ....*....|....*....|....*.
gi 490522388   1 MRLWIFLVATLLLAGCSSHRAPPPNA 26
Cdd:COG3895    1 MKKLLLLLAALLLAGCASAAPPADPA 26
 
Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
18-154 5.99e-52

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 164.49  E-value: 5.99e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522388  18 SHRAPPPNARLSDSITVIAELNDQLNHWYGTPYRYGGMSRGGVDCSGFVMMTFRDrFSLMLPRETRQQAEIGTEIDKDEL 97
Cdd:COG0791   83 SSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYVWGGTSPSGFDCSGLVQYVYRQ-AGISLPRTSADQAAAGTPVSRSEL 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490522388  98 LPGDLVFFKTGSGQNGlHVGIYDTDNQFIHASTSR-GVMRSSLDNVYWRKKFWQARRI 154
Cdd:COG0791  162 QPGDLVFFRTGGGGIS-HVGIYLGNGKFIHASSSGkGVRISSLDSPYWKSRYVGARRV 218
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
34-154 2.19e-50

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 159.55  E-value: 2.19e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522388  34 VIAELNDQLNHWYGTPYRYGGMSRGGVDCSGFVMMTFRDRFSLMLPRETRQQAEIGTEIDKDELLPGDLVFFKTGSgqNG 113
Cdd:PRK10838  66 VKSRIMDQYADWKGVRYRLGGSTKKGIDCSAFVQRTFREQFGLELPRSTYEQQEMGKSVSRSKLRTGDLVLFRAGS--TG 143

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 490522388 114 LHVGIYDTDNQFIHASTSRGVMRSSLDNVYWRKKFWQARRI 154
Cdd:PRK10838 144 RHVGIYIGNNQFVHASTSSGVIISSMNEPYWKKRYNEARRV 184
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 47-153 7.21e-43

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 137.41  E-value: 7.21e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522388   47 GTPYRYGGMSRGGVDCSGFVMMTFRdRFSLMLPRETRQQAEIGTE-IDKDELLPGDLVFFKTGSGQNglHVGIYDTDNQF 125
Cdd:pfam00877   1 GVPYRWGGGSPSGFDCSGLVRYAFA-KVGIELPRSSGQQYNAGKKtIPKSEPQRGDLVFFGTGKGIS--HVGIYLGNGQM 77

                          90       100
                  ....*....|....*....|....*...
gi 490522388  126 IHASTSRGVMRSSLDNVYWRKKFWQARR 153
Cdd:pfam00877  78 LHASTGGGVSISSLNGGYWQKRLVGVRR 105
PRK13914 PRK13914
invasion associated endopeptidase;
29-146 4.27e-14

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 68.29  E-value: 4.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522388  29 SDSITVIAELNDQLnhwyGTPYRYGGMSRGGVDCSGFVMMTFRdRFSLMLPRETRQQAEIGTEIDKDELLPGDLVFFKTG 108
Cdd:PRK13914 364 SSASAIIAEAQKHL----GKAYSWGGNGPTTFDCSGYTKYVFA-KAGISLPRTSGAQYASTTRISESQAKPGDLVFFDYG 438

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 490522388 109 SGQNglHVGIYDTDNQFIHASTSrGVMRSSLDNVYWRK 146
Cdd:PRK13914 439 SGIS--HVGIYVGNGQMINAQDN-GVKYDNIHGSGWGK 473
phage_NlpC_fam TIGR02219
putative phage cell wall peptidase, NlpC/P60 family; Members of this family show sequence ...
 45-147 3.60e-09

putative phage cell wall peptidase, NlpC/P60 family; Members of this family show sequence similarity to members of the NlpC/P60 family described by pfam00877 and by Anantharaman and Aravind (). The NlpC/P60 family includes a number of characterized bacterial cell wall hydrolases. Members of this related family are all found in prophage regions of bacterial genomes. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 131274  Cd Length: 134  Bit Score: 51.79  E-value: 3.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522388   45 WYGTPYRYGGMSRG-GVDCSGFVMMTFRDRFSL---MLPRETRQQAEIGTE-------------IDKDELLPGDLVFFKT 107
Cdd:TIGR02219   8 WIGTPYRHQASTLGvGCDCLGLVRGVWRALYGEepeAPPPYAPDWAEAGGGetlaeaalrhlvpVPCDAAQPGDVLVFRW 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 490522388  108 GSGQNGLHVGIYDTDNQFIHASTSRGVMRSSLDNvYWRKK 147
Cdd:TIGR02219  88 RPGAAAKHAAIAASPTRFIHAYDGAAVVESALVP-WWRRR 126
LolB COG3017
Outer membrane lipoprotein LolB, involved in outer membrane biogenesis [Cell wall/membrane ...
 1-45 2.17e-03

Outer membrane lipoprotein LolB, involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442254  Cd Length: 200  Bit Score: 36.81  E-value: 2.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 490522388   1 MRLWIFLVATLLLAGCSSHRAPPPNARLSDSITVIAELNDQLNHW 45
Cdd:COG3017    5 RRLLLLLLLLLLLAGCATLPPRPTTSPTSPAWQAHQQQLQQLQQW 49
PRK14864 PRK14864
biofilm peroxide resistance protein BsmA;
1-26 4.74e-03

biofilm peroxide resistance protein BsmA;


Pssm-ID: 184866  Cd Length: 104  Bit Score: 34.63  E-value: 4.74e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 490522388   1 MRLWIFLVATLLLAGCSS-----HRAPPPNA 26
Cdd:PRK14864   5 MRRFASLLLTLLLSACSAlqgtpQPAPPPAD 35
MliC COG3895
Membrane-bound inhibitor of C-type lysozyme [Cell wall/membrane/envelope biogenesis];
1-26 7.15e-03

Membrane-bound inhibitor of C-type lysozyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443102  Cd Length: 108  Bit Score: 34.26  E-value: 7.15e-03
                         10        20
                 ....*....|....*....|....*.
gi 490522388   1 MRLWIFLVATLLLAGCSSHRAPPPNA 26
Cdd:COG3895    1 MKKLLLLLAALLLAGCASAAPPADPA 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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