NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|490523082|ref|WP_004388491|]
View 

MULTISPECIES: rhodanese-like domain-containing protein [Cronobacter]

Protein Classification

rhodanese-like domain-containing protein( domain architecture ID 10001806)

rhodanese-like domain-containing protein may have sulfurtransferase activity if an active site cysteine is present

CATH:  3.40.250.10
PubMed:  12151332|17454295

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PspE COG0607
Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; ...
 35-143 2.32e-28

Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Rhodanese-related sulfurtransferase is part of the Pathway/BioSystem: Urea cycle


:

Pssm-ID: 440372 [Multi-domain]  Cd Length: 106  Bit Score: 100.43  E-value: 2.32e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  35 SKVKVITRGEATRLINKEDAVVVDIRQRDDFRKGHIASAMNVlPADIKANNVGELDKHKakPVIVVDGNGLTAQESATAL 114
Cdd:COG0607    1 ASVKEISPAELAELLESEDAVLLDVREPEEFAAGHIPGAINI-PLGELAERLDELPKDK--PIVVYCASGGRSAQAAALL 77

                         90       100
                 ....*....|....*....|....*....
gi 490523082 115 TNAGFEQVYVLKEGVAGWSGENLPLVRGK 143
Cdd:COG0607   78 RRAGYTNVYNLAGGIEAWKAAGLPVEKGK 106
 
Name Accession Description Interval E-value
PspE COG0607
Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; ...
 35-143 2.32e-28

Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Rhodanese-related sulfurtransferase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440372 [Multi-domain]  Cd Length: 106  Bit Score: 100.43  E-value: 2.32e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  35 SKVKVITRGEATRLINKEDAVVVDIRQRDDFRKGHIASAMNVlPADIKANNVGELDKHKakPVIVVDGNGLTAQESATAL 114
Cdd:COG0607    1 ASVKEISPAELAELLESEDAVLLDVREPEEFAAGHIPGAINI-PLGELAERLDELPKDK--PIVVYCASGGRSAQAAALL 77

                         90       100
                 ....*....|....*....|....*....
gi 490523082 115 TNAGFEQVYVLKEGVAGWSGENLPLVRGK 143
Cdd:COG0607   78 RRAGYTNVYNLAGGIEAWKAAGLPVEKGK 106
RHOD cd00158
Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese ...
 44-132 2.12e-23

Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.


Pssm-ID: 238089 [Multi-domain]  Cd Length: 89  Bit Score: 86.97  E-value: 2.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  44 EATRLINKEDAVVVDIRQRDDFRKGHIASAMNVlPADIKANNVGELDKHKAKPVIVVDGNGLTAQESATALTNAGFEQVY 123
Cdd:cd00158    1 ELKELLDDEDAVLLDVREPEEYAAGHIPGAINI-PLSELEERAALLELDKDKPIVVYCRSGNRSARAAKLLRKAGGTNVY 79


                 ....*....
gi 490523082 124 VLKEGVAGW 132
Cdd:cd00158   80 NLEGGMLAW 88
Rhodanese pfam00581
Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single ...
 49-133 1.75e-18

Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.


Pssm-ID: 425764 [Multi-domain]  Cd Length: 92  Bit Score: 74.83  E-value: 1.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082   49 INKEDAVVVDIRQRDDFRKGHIASAMNVLPADIKANNVGELD-------KHKAKPVIVVDGNGLTAQESATALTNAGFEQ 121
Cdd:pfam00581   1 LEDGKVVLIDVRPPEEYAKGHIPGAVNVPLSSLSLPPLPLLElleklleLLKDKPIVVYCNSGNRAAAAAALLKALGYKN 80

                          90
                  ....*....|..
gi 490523082  122 VYVLKEGVAGWS 133
Cdd:pfam00581  81 VYVLDGGFEAWK 92
RHOD smart00450
Rhodanese Homology Domain; An alpha beta fold found duplicated in the Rhodanese protein. The ...
 50-138 1.75e-17

Rhodanese Homology Domain; An alpha beta fold found duplicated in the Rhodanese protein. The the Cysteine containing enzymatically active version of the domain is also found in the CDC25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and stress proteins such as Senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions with a loss of the cysteine are also seen in Dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases. These are likely to play a role in protein interactions.


Pssm-ID: 197731 [Multi-domain]  Cd Length: 100  Bit Score: 72.49  E-value: 1.75e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082    50 NKEDAVVVDIRQRDDFRKGHIASAMNV-----------LPADIKANNVGELDKHKAKPVIVVDGNGLTAQESATALTNAG 118
Cdd:smart00450   1 NDEKVVLLDVRSPEEYEGGHIPGAVNIplselldrrgeLDILEFEELLKRLGLDKDKPVVVYCRSGNRSAKAAWLLRELG 80

                           90       100
                   ....*....|....*....|
gi 490523082   119 FEQVYVLKEGVAGWSGENLP 138
Cdd:smart00450  81 FKNVYLLDGGYKEWSAAGPP 100
glpE PRK00162
thiosulfate sulfurtransferase GlpE;
38-141 7.33e-11

thiosulfate sulfurtransferase GlpE;


Pssm-ID: 178908 [Multi-domain]  Cd Length: 108  Bit Score: 55.41  E-value: 7.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  38 KVITRGEATRLINKEDAVVVDIRQRDDFRKGHIASAMNV----LPADIKANnvgELDkhkaKPVIVVDGNGLTAQESATA 113
Cdd:PRK00162   5 ECINVEQAHQKLQEGGAVLVDIRDPQSFAMGHAPGAFHLtndsLGAFMRQA---DFD----TPVMVMCYHGNSSQGAAQY 77

                         90       100
                 ....*....|....*....|....*...
gi 490523082 114 LTNAGFEQVYVLKEGVAGWSGENLPLVR 141
Cdd:PRK00162  78 LLQQGFDVVYSIDGGFEAWRRTFPAEVA 105
 
Name Accession Description Interval E-value
PspE COG0607
Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; ...
 35-143 2.32e-28

Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Rhodanese-related sulfurtransferase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440372 [Multi-domain]  Cd Length: 106  Bit Score: 100.43  E-value: 2.32e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  35 SKVKVITRGEATRLINKEDAVVVDIRQRDDFRKGHIASAMNVlPADIKANNVGELDKHKakPVIVVDGNGLTAQESATAL 114
Cdd:COG0607    1 ASVKEISPAELAELLESEDAVLLDVREPEEFAAGHIPGAINI-PLGELAERLDELPKDK--PIVVYCASGGRSAQAAALL 77

                         90       100
                 ....*....|....*....|....*....
gi 490523082 115 TNAGFEQVYVLKEGVAGWSGENLPLVRGK 143
Cdd:COG0607   78 RRAGYTNVYNLAGGIEAWKAAGLPVEKGK 106
RHOD cd00158
Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese ...
 44-132 2.12e-23

Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.


Pssm-ID: 238089 [Multi-domain]  Cd Length: 89  Bit Score: 86.97  E-value: 2.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  44 EATRLINKEDAVVVDIRQRDDFRKGHIASAMNVlPADIKANNVGELDKHKAKPVIVVDGNGLTAQESATALTNAGFEQVY 123
Cdd:cd00158    1 ELKELLDDEDAVLLDVREPEEYAAGHIPGAINI-PLSELEERAALLELDKDKPIVVYCRSGNRSARAAKLLRKAGGTNVY 79


                 ....*....
gi 490523082 124 VLKEGVAGW 132
Cdd:cd00158   80 NLEGGMLAW 88
Rhodanese pfam00581
Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single ...
 49-133 1.75e-18

Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.


Pssm-ID: 425764 [Multi-domain]  Cd Length: 92  Bit Score: 74.83  E-value: 1.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082   49 INKEDAVVVDIRQRDDFRKGHIASAMNVLPADIKANNVGELD-------KHKAKPVIVVDGNGLTAQESATALTNAGFEQ 121
Cdd:pfam00581   1 LEDGKVVLIDVRPPEEYAKGHIPGAVNVPLSSLSLPPLPLLElleklleLLKDKPIVVYCNSGNRAAAAAALLKALGYKN 80

                          90
                  ....*....|..
gi 490523082  122 VYVLKEGVAGWS 133
Cdd:pfam00581  81 VYVLDGGFEAWK 92
RHOD smart00450
Rhodanese Homology Domain; An alpha beta fold found duplicated in the Rhodanese protein. The ...
 50-138 1.75e-17

Rhodanese Homology Domain; An alpha beta fold found duplicated in the Rhodanese protein. The the Cysteine containing enzymatically active version of the domain is also found in the CDC25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and stress proteins such as Senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions with a loss of the cysteine are also seen in Dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases. These are likely to play a role in protein interactions.


Pssm-ID: 197731 [Multi-domain]  Cd Length: 100  Bit Score: 72.49  E-value: 1.75e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082    50 NKEDAVVVDIRQRDDFRKGHIASAMNV-----------LPADIKANNVGELDKHKAKPVIVVDGNGLTAQESATALTNAG 118
Cdd:smart00450   1 NDEKVVLLDVRSPEEYEGGHIPGAVNIplselldrrgeLDILEFEELLKRLGLDKDKPVVVYCRSGNRSAKAAWLLRELG 80

                           90       100
                   ....*....|....*....|
gi 490523082   119 FEQVYVLKEGVAGWSGENLP 138
Cdd:smart00450  81 FKNVYLLDGGYKEWSAAGPP 100
glpE PRK00162
thiosulfate sulfurtransferase GlpE;
38-141 7.33e-11

thiosulfate sulfurtransferase GlpE;


Pssm-ID: 178908 [Multi-domain]  Cd Length: 108  Bit Score: 55.41  E-value: 7.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  38 KVITRGEATRLINKEDAVVVDIRQRDDFRKGHIASAMNV----LPADIKANnvgELDkhkaKPVIVVDGNGLTAQESATA 113
Cdd:PRK00162   5 ECINVEQAHQKLQEGGAVLVDIRDPQSFAMGHAPGAFHLtndsLGAFMRQA---DFD----TPVMVMCYHGNSSQGAAQY 77

                         90       100
                 ....*....|....*....|....*...
gi 490523082 114 LTNAGFEQVYVLKEGVAGWSGENLPLVR 141
Cdd:PRK00162  78 LLQQGFDVVYSIDGGFEAWRRTFPAEVA 105
GlpE_ST cd01444
GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain ...
 40-132 1.95e-10

GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a catalytically active cysteine.


Pssm-ID: 238721 [Multi-domain]  Cd Length: 96  Bit Score: 53.80  E-value: 1.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  40 ITRGEATRLINK-EDAVVVDIRQRDDFRK--GHIASAMnVLPADIKANNVGELDKHKakPVIVVDGNGLTAQESATALTN 116
Cdd:cd01444    2 ISVDELAELLAAgEAPVLLDVRDPASYAAlpDHIPGAI-HLDEDSLDDWLGDLDRDR--PVVVYCYHGNSSAQLAQALRE 78

                         90
                 ....*....|....*.
gi 490523082 117 AGFEQVYVLKEGVAGW 132
Cdd:cd01444   79 AGFTDVRSLAGGFEAW 94
RHOD_PspE2 cd01521
Member of the Rhodanese Homology Domain superfamily. This CD includes the putative ...
 50-139 1.98e-08

Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins.


Pssm-ID: 238779 [Multi-domain]  Cd Length: 110  Bit Score: 49.27  E-value: 1.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  50 NKEDAVVVDIRQRDDFRKGHIASAMNVLPADIKANNVGELDkhKAKPVIV-VDG---NGltAQESATALTNAGFeQVYVL 125
Cdd:cd01521   22 GKPDFVLVDVRSAEAYARGHVPGAINLPHREICENATAKLD--KEKLFVVyCDGpgcNG--ATKAALKLAELGF-PVKEM 96

                         90
                 ....*....|....
gi 490523082 126 KEGVAGWSGENLPL 139
Cdd:cd01521   97 IGGLDWWKREGYAT 110
PRK08762 PRK08762
molybdopterin-synthase adenylyltransferase MoeB;
40-141 7.58e-08

molybdopterin-synthase adenylyltransferase MoeB;


Pssm-ID: 236337 [Multi-domain]  Cd Length: 376  Bit Score: 49.62  E-value: 7.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  40 ITRGEATRLInKEDAVVVDIRQRDDFRKGHIASAMNV----LPADIkANNVGELDKhkakPVIVVDGNGLTAQESATALT 115
Cdd:PRK08762   5 ISPAEARARA-AQGAVLIDVREAHERASGQAEGALRIprgfLELRI-ETHLPDRDR----EIVLICASGTRSAHAAATLR 78

                         90       100
                 ....*....|....*....|....*.
gi 490523082 116 NAGFEQVYVLKEGVAGWSGENLPLVR 141
Cdd:PRK08762  79 ELGYTRVASVAGGFSAWKDAGLPLER 104
SseA COG2897
3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion ...
 48-142 2.72e-07

3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism];


Pssm-ID: 442142 [Multi-domain]  Cd Length: 262  Bit Score: 47.86  E-value: 2.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  48 LINKEDAVVVDIR-----QRDDFRKGHIASAMNV----------------LPADIK-ANNVGELDKHKAKPVIVVDGNGL 105
Cdd:COG2897    4 HLDDPDVVILDVRwdlpdGRAAYEAGHIPGAVFLdldtdlsdprspgrhpLPSPEAfAALLGALGISNDTTVVVYDDGGG 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 490523082 106 TaqeSAT----ALTNAGFEQVYVLKEGVAGWSGENLPLVRG 142
Cdd:COG2897   84 L---FAArawwLLRYAGHEDVRVLDGGLAAWKAAGLPLETG 121
TST_Repeat_2 cd01449
Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of ...
 40-124 3.15e-06

Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue.


Pssm-ID: 238726 [Multi-domain]  Cd Length: 118  Bit Score: 43.39  E-value: 3.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  40 ITRGEATRLINKEDAVVVDIRQRDDF-----------RKGHIASAMNV------------LPADIKANNVGELDKHKAKP 96
Cdd:cd01449    1 VTAEEVLANLDSGDVQLVDARSPERFrgevpeprpglRSGHIPGAVNIpwtslldedgtfKSPEELRALFAALGITPDKP 80

                         90       100
                 ....*....|....*....|....*...
gi 490523082  97 VIVVDGNGLTAQESATALTNAGFEQVYV 124
Cdd:cd01449   81 VIVYCGSGVTACVLLLALELLGYKNVRL 108
RHOD_YgaP cd01527
Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, ...
 37-138 4.51e-06

Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases.


Pssm-ID: 238785 [Multi-domain]  Cd Length: 99  Bit Score: 42.47  E-value: 4.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  37 VKVITRGEATRLINkEDAVVVDIRQRDDFRKGHIASAMNVLPADIKANNVGELDkhkAKPVIVVDGNGLTAQESATALTN 116
Cdd:cd01527    1 LTTISPNDACELLA-QGAVLVDIREPDEYLRERIPGARLVPLSQLESEGLPLVG---ANAIIFHCRSGMRTQQNAERLAA 76

                         90       100
                 ....*....|....*....|..
gi 490523082 117 AGFEQVYVLKEGVAGWSGENLP 138
Cdd:cd01527   77 ISAGEAYVLEGGLDAWKAAGLP 98
4RHOD_Repeat_4 cd01535
Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative ...
 56-142 4.56e-06

Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative catalytic Cys residue.


Pssm-ID: 238793 [Multi-domain]  Cd Length: 145  Bit Score: 43.65  E-value: 4.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  56 VVDIRQRDDFRKGHIASAMNVLPADIKAnnvgELDK-HKAKPVIVVDGNGLTAQESATALTNAGFEQVYVLKEGVAGWSG 134
Cdd:cd01535   14 VVDVTASANYVKRHIPGAWWVLRAQLAQ----ALEKlPAAERYVLTCGSSLLARFAAADLAALTVKPVFVLEGGTAAWIA 89


                 ....*...
gi 490523082 135 ENLPLVRG 142
Cdd:cd01535   90 AGLPVESG 97
PRK05597 PRK05597
molybdopterin biosynthesis protein MoeB; Validated
 52-133 4.62e-05

molybdopterin biosynthesis protein MoeB; Validated


Pssm-ID: 235526 [Multi-domain]  Cd Length: 355  Bit Score: 41.78  E-value: 4.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  52 EDAVVVDIRQRDDFRKGHIASAMNVLPADIKAN-NVGELDKhkAKPVIVVDGNGLTAQESATALTNAGFEQVYVLKEGVA 130
Cdd:PRK05597 273 DGVTLIDVREPSEFAAYSIPGAHNVPLSAIREGaNPPSVSA--GDEVVVYCAAGVRSAQAVAILERAGYTGMSSLDGGIE 350


                 ...
gi 490523082 131 GWS 133
Cdd:PRK05597 351 GWL 353
4RHOD_Repeats cd01529
Member of the Rhodanese Homology Domain superfamily. This CD includes putative ...
 56-132 7.57e-05

Member of the Rhodanese Homology Domain superfamily. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. Only the second and most of the fourth repeats contain the putative catalytic Cys residue. This CD aligns the 1st , 2nd, 3rd, and 4th repeats.


Pssm-ID: 238787 [Multi-domain]  Cd Length: 96  Bit Score: 39.20  E-value: 7.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  56 VVDIRQRDDFRKGHIASAMNVlPADIKANNVGELDKHKA----KPVIVVDGNGLTAQESATALTNAGFEQVYVLKEGVAG 131
Cdd:cd01529   15 LLDVRAEDEYAAGHLPGKRSI-PGAALVLRSQELQALEApgraTRYVLTCDGSLLARFAAQELLALGGKPVALLDGGTSA 93


                 .
gi 490523082 132 W 132
Cdd:cd01529   94 W 94
RHOD_YceA cd01518
Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, ...
 44-129 7.83e-05

Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins.


Pssm-ID: 238776 [Multi-domain]  Cd Length: 101  Bit Score: 39.49  E-value: 7.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  44 EATRLINKEDAVVVDIRQRDDFRKGHIASAMNV-------LPADIKANnvgeLDKHKAKPVIVVDGNGLTAQESATALTN 116
Cdd:cd01518    8 EWNELLEDPEVVLLDVRNDYEYDIGHFKGAVNPdvdtfreFPFWLDEN----LDLLKGKKVLMYCTGGIRCEKASAYLKE 83

                         90
                 ....*....|...
gi 490523082 117 AGFEQVYVLKEGV 129
Cdd:cd01518   84 RGFKNVYQLKGGI 96
RHOD_Pyr_redox cd01524
Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus ...
 49-120 9.46e-05

Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar rhodanese-like domains found C-terminal of the pyridine nucleotide-disulphide oxidoreductase (Pyr-redox) domain and the Pyr-redox dimerization domain.


Pssm-ID: 238782 [Multi-domain]  Cd Length: 90  Bit Score: 38.79  E-value: 9.46e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490523082  49 INKEDAVVVDIRQRDDFRKGHIASAMNVLPADIKAnNVGELDKHkaKPVIVVDGNGLTAQESATALTNAGFE 120
Cdd:cd01524    9 YRADGVTLIDVRTPQEFEKGHIKGAINIPLDELRD-RLNELPKD--KEIIVYCAVGLRGYIAARILTQNGFK 77
4RHOD_Repeat_1 cd01532
Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative ...
 47-132 1.19e-04

Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative catalytic Cys residue.


Pssm-ID: 238790 [Multi-domain]  Cd Length: 92  Bit Score: 38.62  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  47 RLINKEDAVVVDIRQRDDFRKGHIASAMNVLPADIkannvgELDKH-----KAKPVIVVDGNGLT--AQESATALTNAGF 119
Cdd:cd01532    4 ALLAREEIALIDVREEDPFAQSHPLWAANLPLSRL------ELDAWvriprRDTPIVVYGEGGGEdlAPRAARRLSELGY 77

                         90
                 ....*....|...
gi 490523082 120 EQVYVLKEGVAGW 132
Cdd:cd01532   78 TDVALLEGGLQGW 90
SseA COG2897
3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion ...
 39-124 1.32e-04

3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism];


Pssm-ID: 442142 [Multi-domain]  Cd Length: 262  Bit Score: 40.16  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  39 VITRGEATRLINKEDAVVVDIRQRDDF---------RKGHIASAMNV-------------LPADIKAnNVGELDKHKAKP 96
Cdd:COG2897  139 LADADEVLAALGDPDAVLVDARSPERYrgevepidpRAGHIPGAVNLpwtdlldedgtfkSAEELRA-LFAALGIDPDKP 217

                         90       100
                 ....*....|....*....|....*...
gi 490523082  97 VIVVDGNGLTAQESATALTNAGFEQVYV 124
Cdd:COG2897  218 VITYCGSGVRAAHTWLALELLGYPNVRL 245
RHOD_1 cd01522
Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative ...
 47-131 3.42e-04

Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins.


Pssm-ID: 238780 [Multi-domain]  Cd Length: 117  Bit Score: 38.08  E-value: 3.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  47 RLINKEDAVVVDIRQRDDFRK-GHIASAMNV-----LPADIKANNVGELDKH--KAKPVIVVDGNGLTAQESATALTNAG 118
Cdd:cd01522    9 LLQADPQAVLVDVRTEAEWKFvGGVPDAVHVawqvyPDMEINPNFLAELEEKvgKDRPVLLLCRSGNRSIAAAEAAAQAG 88

                         90
                 ....*....|...
gi 490523082 119 FEQVYVLKEGVAG 131
Cdd:cd01522   89 FTNVYNVLEGFEG 101
sseA PRK11493
3-mercaptopyruvate sulfurtransferase; Provisional
 49-142 4.20e-04

3-mercaptopyruvate sulfurtransferase; Provisional


Pssm-ID: 236917 [Multi-domain]  Cd Length: 281  Bit Score: 38.92  E-value: 4.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  49 INKEDAVVVDIR-------QRD---DFRKGHIASAM---------------NVLP-ADIKANNVGELDKHKAKPVIVVD- 101
Cdd:PRK11493  16 IDDPEIQIIDARmappgqeDRDvaaEYRAGHIPGAVffdiealsdhtsplpHMMPrPETFAVAMRELGVNQDKHLVVYDe 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 490523082 102 GNGLTAQESATALTNAGFEQVYVLKEGVAGWSGENLPLVRG 142
Cdd:PRK11493  96 GNLFSAPRAWWMLRTFGVEKVSILAGGLAGWQRDDLLLEEG 136
RHOD_2 cd01528
Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes ...
 52-135 5.06e-04

Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains.


Pssm-ID: 238786 [Multi-domain]  Cd Length: 101  Bit Score: 36.99  E-value: 5.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  52 EDAVVVDIRQRDDFRKGHIASAMNvLPADIKANNVGELDKH-KAKPVIVVDGNGLTAQESATALTNAGFEQVYVLKEGVA 130
Cdd:cd01528   16 EEPVLIDVREPEELEIAFLPGFLH-LPMSEIPERSKELDSDnPDKDIVVLCHHGGRSMQVAQWLLRQGFENVYNLQGGID 94


                 ....*
gi 490523082 131 GWSGE 135
Cdd:cd01528   95 AWSLE 99
RHOD_Lact_B cd01523
Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with ...
 47-133 5.25e-04

Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain.


Pssm-ID: 238781 [Multi-domain]  Cd Length: 100  Bit Score: 37.09  E-value: 5.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  47 RLINKEDAVVVDIRQRDDFRKGHI----ASAMNVLPADIKANNVGELDK-HKAKPVIVVDGNGLTAQESATALTNAGFEQ 121
Cdd:cd01523    9 RLLAGQPLFILDVRNESDYERWKIdgenNTPYFDPYFDFLEIEEDILDQlPDDQEVTVICAKEGSSQFVAELLAERGYDV 88

                         90
                 ....*....|..
gi 490523082 122 VYvLKEGVAGWS 133
Cdd:cd01523   89 DY-LAGGMKAWS 99
RHOD_Kc cd01525
Member of the Rhodanese Homology Domain superfamily. Included in this CD are the ...
 51-129 9.01e-04

Member of the Rhodanese Homology Domain superfamily. Included in this CD are the rhodanese-like domains found C-terminal of the serine/threonine protein kinases catalytic (S_TKc) domain and the Tre-2, BUB2p, Cdc16p (TBC) domain. The putative active site Cys residue is not present in this CD.


Pssm-ID: 238783 [Multi-domain]  Cd Length: 105  Bit Score: 36.66  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  51 KEDAVVVDIRQRDDFRKGHIASAMNV--------LPADIKANNVGELDKHKAKPVIVVDGNGLTAQESATALTNAGFEQV 122
Cdd:cd01525   14 PAKLAAVDIRSSPDFRRGHIEGSINIpfssvflkEGELEQLPTVPRLENYKGKIIVIVSHSHKHAALFAAFLVKCGVPRV 93


                 ....*..
gi 490523082 123 YVLKEGV 129
Cdd:cd01525   94 CILDGGI 100
PRK01415 PRK01415
hypothetical protein; Validated
 48-129 3.82e-03

hypothetical protein; Validated


Pssm-ID: 167229 [Multi-domain]  Cd Length: 247  Bit Score: 36.08  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  48 LINKEDAVVVDIRQRDDFRKGHIASAMN-------VLPADIKANNvgELdkHKAKPVIVVDGNGLTAQESATALTNAGFE 120
Cdd:PRK01415 122 FITKQDVIVIDTRNDYEVEVGTFKSAINpntktfkQFPAWVQQNQ--EL--LKGKKIAMVCTGGIRCEKSTSLLKSIGYD 197


                 ....*....
gi 490523082 121 QVYVLKEGV 129
Cdd:PRK01415 198 EVYHLKGGI 206
Polysulfide_ST cd01447
Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as ...
 44-132 4.71e-03

Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a terminal electron acceptor. The active site contains the same conserved cysteine that is the catalytic residue in other Rhodanese Homology Domain proteins.


Pssm-ID: 238724 [Multi-domain]  Cd Length: 103  Bit Score: 34.71  E-value: 4.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  44 EATRLINKEDAVVVDIRQRDDF-RKGHIASAMNVLPA--DIKANNVGELDK---HKAKPVIVVDGNGLTAQESATALTNA 117
Cdd:cd01447    5 DARALLGSPGVLLVDVRDPRELeRTGMIPGAFHAPRGmlEFWADPDSPYHKpafAEDKPFVFYCASGWRSALAGKTLQDM 84

                         90
                 ....*....|....*
gi 490523082 118 GFEQVYVLKEGVAGW 132
Cdd:cd01447   85 GLKPVYNIEGGFKDW 99
PRK00142 PRK00142
rhodanese-related sulfurtransferase;
48-130 6.97e-03

rhodanese-related sulfurtransferase;


Pssm-ID: 234663 [Multi-domain]  Cd Length: 314  Bit Score: 35.21  E-value: 6.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490523082  48 LINKEDAVVVDIRQRDDFRKGHIASAMNV-------LPADIKANnvgeLDKHKAKPVIVVDGNGLTAqESATA-LTNAGF 119
Cdd:PRK00142 122 LLDDPDVVFIDMRNDYEYEIGHFENAIEPdietfreFPPWVEEN----LDPLKDKKVVMYCTGGIRC-EKASAwMKHEGF 196

                         90
                 ....*....|.
gi 490523082 120 EQVYVLKEGVA 130
Cdd:PRK00142 197 KEVYQLEGGII 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH