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Conserved domains on  [gi|490530969|ref|WP_004396143|]
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MULTISPECIES: Chromate resistance protein ChrB [Thermoanaerobacter]

Protein Classification

eukaryotic translation initiation factor 2 subunit alpha( domain architecture ID 1000628)

eukaryotic translation initiation factor 2 subunit alpha is part of the eIF-2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

CATH:  1.10.150.190|2.40.50.140
Gene Ontology:  GO:0003723|GO:0003743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ChrB_N super family cl48396
Protein ChrB, N-terminal; This is the N-terminal domain found in Chromate resistance protein ...
 18-170 7.14e-17

Protein ChrB, N-terminal; This is the N-terminal domain found in Chromate resistance protein ChrB, a protein involved in the reduction of chromate accumulation and are essential for chromate resistance. This domain may be involved in DNA binding and contains two highly conserved arginine residues important for its function.


The actual alignment was detected with superfamily member pfam20229:

Pssm-ID: 466380  Cd Length: 159  Bit Score: 73.47  E-value: 7.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490530969   18 RVTIWRRIKKIGALYLQQSVCIVPYMERLVKEIEKLKDEIKGFGGDFKAFEVVALDEEIEKDVIEQFNHQRREEYSEIKE 97
Cdd:pfam20229   1 RVAVWRELRRVGALSLGQGVWAVPDVPAFADGLDRARELAERGGGEVVVLDATGRDPADAARLRAAFTAARSDEWAEFLA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490530969   98 QCEEFFKEIEKEIARKNFTFAELEENEDELNKLYKWFEKVAQRDVFECEMKKEVKELLEKASRDFEYFASLVY 170
Cdd:pfam20229  81 DCGKFEAEIDKEIRIEKFTLAELEEEEQSLERLRRWHRDLKARDVFGAPEAAEAEQRLRHCAEALEDYAERVF 153
 
Name Accession Description Interval E-value
ChrB_N pfam20229
Protein ChrB, N-terminal; This is the N-terminal domain found in Chromate resistance protein ...
 18-170 7.14e-17

Protein ChrB, N-terminal; This is the N-terminal domain found in Chromate resistance protein ChrB, a protein involved in the reduction of chromate accumulation and are essential for chromate resistance. This domain may be involved in DNA binding and contains two highly conserved arginine residues important for its function.


Pssm-ID: 466380  Cd Length: 159  Bit Score: 73.47  E-value: 7.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490530969   18 RVTIWRRIKKIGALYLQQSVCIVPYMERLVKEIEKLKDEIKGFGGDFKAFEVVALDEEIEKDVIEQFNHQRREEYSEIKE 97
Cdd:pfam20229   1 RVAVWRELRRVGALSLGQGVWAVPDVPAFADGLDRARELAERGGGEVVVLDATGRDPADAARLRAAFTAARSDEWAEFLA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490530969   98 QCEEFFKEIEKEIARKNFTFAELEENEDELNKLYKWFEKVAQRDVFECEMKKEVKELLEKASRDFEYFASLVY 170
Cdd:pfam20229  81 DCGKFEAEIDKEIRIEKFTLAELEEEEQSLERLRRWHRDLKARDVFGAPEAAEAEQRLRHCAEALEDYAERVF 153
PTZ00248 PTZ00248
eukaryotic translation initiation factor 2 subunit 1; Provisional
 43-97 9.16e-03

eukaryotic translation initiation factor 2 subunit 1; Provisional


Pssm-ID: 240329 [Multi-domain]  Cd Length: 319  Bit Score: 35.79  E-value: 9.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490530969  43 MERLVKEIEKLKDEIKGFGGDFK---AFEVVALDEEIEKDVIEQFNHQRREEYSEIKE 97
Cdd:PTZ00248 242 MEIIGAALEAIKEVIKKKGGDFKvkgEPEVVGGDEEDLEELLEKAEEEEEEDDYSESE 299
 
Name Accession Description Interval E-value
ChrB_N pfam20229
Protein ChrB, N-terminal; This is the N-terminal domain found in Chromate resistance protein ...
 18-170 7.14e-17

Protein ChrB, N-terminal; This is the N-terminal domain found in Chromate resistance protein ChrB, a protein involved in the reduction of chromate accumulation and are essential for chromate resistance. This domain may be involved in DNA binding and contains two highly conserved arginine residues important for its function.


Pssm-ID: 466380  Cd Length: 159  Bit Score: 73.47  E-value: 7.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490530969   18 RVTIWRRIKKIGALYLQQSVCIVPYMERLVKEIEKLKDEIKGFGGDFKAFEVVALDEEIEKDVIEQFNHQRREEYSEIKE 97
Cdd:pfam20229   1 RVAVWRELRRVGALSLGQGVWAVPDVPAFADGLDRARELAERGGGEVVVLDATGRDPADAARLRAAFTAARSDEWAEFLA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490530969   98 QCEEFFKEIEKEIARKNFTFAELEENEDELNKLYKWFEKVAQRDVFECEMKKEVKELLEKASRDFEYFASLVY 170
Cdd:pfam20229  81 DCGKFEAEIDKEIRIEKFTLAELEEEEQSLERLRRWHRDLKARDVFGAPEAAEAEQRLRHCAEALEDYAERVF 153
PTZ00248 PTZ00248
eukaryotic translation initiation factor 2 subunit 1; Provisional
 43-97 9.16e-03

eukaryotic translation initiation factor 2 subunit 1; Provisional


Pssm-ID: 240329 [Multi-domain]  Cd Length: 319  Bit Score: 35.79  E-value: 9.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490530969  43 MERLVKEIEKLKDEIKGFGGDFK---AFEVVALDEEIEKDVIEQFNHQRREEYSEIKE 97
Cdd:PTZ00248 242 MEIIGAALEAIKEVIKKKGGDFKvkgEPEVVGGDEEDLEELLEKAEEEEEEDDYSESE 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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