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Conserved domains on  [gi|490535313|ref|WP_004400479|]
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MULTISPECIES: penicillin-binding protein 2 [Thermoanaerobacter]

Protein Classification

peptidoglycan D,D-transpeptidase FtsI family protein( domain architecture ID 11433609)

peptidoglycan D,D-transpeptidase FtsI (penicillin-binding protein (PBP) 2) family protein is a membrane-associated enzyme that is most likely involved in the synthesis of cross-linked peptidoglycan

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
2-474 5.74e-149

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 436.56  E-value: 5.74e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313   2 SNLNRNIKILFGVFSVLFFGLIAYLTYFQIYERDRLITSSYsvyNRRLIEQEKKILRGSILDRNGIVLAKSI----IEAD 77
Cdd:COG0768    8 RLFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAE---ENRIRTVPIPAPRGLIYDRNGNVLATNVpvysLYAD 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  78 GSQ--------------------------------------------------------------KREYLDGPAFAQVIG 95
Cdd:COG0768   85 PEEvkdpeetaeklakllgldpeelrkklkkksrfpvylkrnlspeeaariralklpgvyveaeyKRYYPYGELAAHVLG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  96 YSRRIY---QQGNAGIEKAYDRELLGMVGndpiiILRKLVLAKGQV------------GDNVYLTIDKTLQDLAYKEMEG 160
Cdd:COG0768  165 YVGEINggdGIGKSGLEKAYEDLLRGTPG-----KRRVEVDARGRVirdlgeekppvpGKDLVLTIDSDLQKIAEEALKK 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 161 -------KKGAVVVLNPKTGEILAMVSTPSYDPNTLGEnwkeimtSPDNVVLNRATQGLYPPGSVFKIVTTAAVL---TY 230
Cdd:COG0768  240 aveeykaKSGAVVVMDPKTGEILAMASYPSFDPNLFVG-------GPDEPLRNRAVQGTYEPGSTFKPFTAAAALeegVI 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 231 EPelyNKTFDCKGYIIVDGNRINDFGGIAHGIEDFKQAFYRSCNSFFIQIGLDLGSENLQSMAYNFGLDKRVPLEIDTAK 310
Cdd:COG0768  313 TP---DTTFDCPGYYRVGGRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLYDYLKKFGLGQKTGIDLPGEA 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 311 N-YFPPIE--GKVALAETSIGQGkILVTPLTMALVASAVANDGVIMKPYLMRYVADPISGTVIEKSTPSQYLnpISKKVA 387
Cdd:COG0768  390 SgLLPSPKrwYPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVVKEEPEVLRRV--ISPETA 466
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 388 DTIKQLMIGAVNDKEGTGKAAQIPGITVAGKTGTAENPHGAPH--------AWFVGFAPAENPQIVVSVIVENGGE---G 456
Cdd:COG0768  467 ETVREGMEGVVNEPGGTARRAAIPGYRVAGKTGTAQVVDIGNGgyykgrhiASFVGFAPADNPRYAVAVVVENPGGgayG 546
                        570
                 ....*....|....*...
gi 490535313 457 GKVAAPIARDIIRSYLTK 474
Cdd:COG0768  547 GTVAAPVFREIMEAYLRL 564
 
Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
2-474 5.74e-149

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 436.56  E-value: 5.74e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313   2 SNLNRNIKILFGVFSVLFFGLIAYLTYFQIYERDRLITSSYsvyNRRLIEQEKKILRGSILDRNGIVLAKSI----IEAD 77
Cdd:COG0768    8 RLFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAE---ENRIRTVPIPAPRGLIYDRNGNVLATNVpvysLYAD 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  78 GSQ--------------------------------------------------------------KREYLDGPAFAQVIG 95
Cdd:COG0768   85 PEEvkdpeetaeklakllgldpeelrkklkkksrfpvylkrnlspeeaariralklpgvyveaeyKRYYPYGELAAHVLG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  96 YSRRIY---QQGNAGIEKAYDRELLGMVGndpiiILRKLVLAKGQV------------GDNVYLTIDKTLQDLAYKEMEG 160
Cdd:COG0768  165 YVGEINggdGIGKSGLEKAYEDLLRGTPG-----KRRVEVDARGRVirdlgeekppvpGKDLVLTIDSDLQKIAEEALKK 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 161 -------KKGAVVVLNPKTGEILAMVSTPSYDPNTLGEnwkeimtSPDNVVLNRATQGLYPPGSVFKIVTTAAVL---TY 230
Cdd:COG0768  240 aveeykaKSGAVVVMDPKTGEILAMASYPSFDPNLFVG-------GPDEPLRNRAVQGTYEPGSTFKPFTAAAALeegVI 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 231 EPelyNKTFDCKGYIIVDGNRINDFGGIAHGIEDFKQAFYRSCNSFFIQIGLDLGSENLQSMAYNFGLDKRVPLEIDTAK 310
Cdd:COG0768  313 TP---DTTFDCPGYYRVGGRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLYDYLKKFGLGQKTGIDLPGEA 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 311 N-YFPPIE--GKVALAETSIGQGkILVTPLTMALVASAVANDGVIMKPYLMRYVADPISGTVIEKSTPSQYLnpISKKVA 387
Cdd:COG0768  390 SgLLPSPKrwYPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVVKEEPEVLRRV--ISPETA 466
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 388 DTIKQLMIGAVNDKEGTGKAAQIPGITVAGKTGTAENPHGAPH--------AWFVGFAPAENPQIVVSVIVENGGE---G 456
Cdd:COG0768  467 ETVREGMEGVVNEPGGTARRAAIPGYRVAGKTGTAQVVDIGNGgyykgrhiASFVGFAPADNPRYAVAVVVENPGGgayG 546
                        570
                 ....*....|....*...
gi 490535313 457 GKVAAPIARDIIRSYLTK 474
Cdd:COG0768  547 GTVAAPVFREIMEAYLRL 564
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
6-474 1.01e-126

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 380.72  E-value: 1.01e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313    6 RNIKILFGVFSVLFFGLIAYLTYFQIYERDRLITSSYSvyNRRlieQEKKIL--RGSILDRNGIVLAKSI---------- 73
Cdd:TIGR03423   1 RRALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSED--NRI---RLVPIPppRGLILDRNGVLLADNRpsfsleivpe 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313   74 --------------------------------------------------------------IEADGSQKREYLDGPAFA 91
Cdd:TIGR03423  76 kvddldatldrlaklldldpediarflkelkrsrrfepiplksdlteeevarfavnqyrlpgVEIEARLKRYYPYGELAA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313   92 QVIGYSRRIYQQ----------------GNAGIEKAYDRELLGMVGndpiiILRKLVLAKGQV-----------GDNVYL 144
Cdd:TIGR03423 156 HVLGYVGEINEEdlerlepanyaggdyiGKSGIEKYYEDELRGKPG-----YREVEVNARGRVirtlsrvppvpGKDLVL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  145 TIDKTLQDLAYKEMEGKKGAVVVLNPKTGEILAMVSTPSYDPNTL-----GENWKEIMTSPDNVVLNRATQGLYPPGSVF 219
Cdd:TIGR03423 231 TIDARLQQAAEKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFvdgisSKDYKALLNDPDRPLLNRAIQGVYPPGSTF 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  220 KIVTTAAVL---TYEPElynKTFDCKGYIIVDGNRINDFGGIAHGIEDFKQAFYRSCNSFFIQIGLDLGSENLQSMAYNF 296
Cdd:TIGR03423 311 KPVVALAALeegVITPE---TRIYCPGYFQLGGRRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRF 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  297 GLDKRVPLEI---------DTA-------KNYFPpiegkvalAET---SIGQGKILVTPLTMALVASAVANDGVIMKPYL 357
Cdd:TIGR03423 388 GFGQKTGIDLpgeksglvpSREwkrkrfgQPWYP--------GDTlnvSIGQGYVLVTPLQLAVATAALANGGKLYKPHL 459
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  358 MRYVADPISGTVIEKSTPSQYLNPISKKVADTIKQLMIGAVNDKEGTGKAAQIP-GITVAGKTGTAE----------NPH 426
Cdd:TIGR03423 460 VKSIEDPDGGVVRRTEPEVLRPLPISPENLDVVREGMRDVVNGPGGTARRARLGlPYKMAGKTGTAQvvslkqgekyDAE 539
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|...
gi 490535313  427 GAP-----HAWFVGFAPAENPQIVVSVIVENGGEGGKVAAPIARDIIRSYLTK 474
Cdd:TIGR03423 540 QIPerlrdHALFVAFAPYDNPKIAVAVIVEHGGGGSSAAAPIARKIMDAYLLG 592
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
163-468 2.57e-73

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 233.08  E-value: 2.57e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  163 GAVVVLNPKTGEILAMVSTPSYDPNTLGENWkeimtspdnvvLNRATQGLYPPGSVFKIVTTAAVL---TYEPelyNKTF 239
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFIGPL-----------RNRAVTSRYEPGSTFKPFTALAALdngVLKP---DETI 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  240 DCKGYIIVDGNRINDFGGIAHGIEDFKQAFYRSCNSFFIQIGLDLGSENLQSMAYNFGLDKRVPLEIDTAKNYFPP---I 316
Cdd:pfam00905  67 FDWPGKQQGGKSIGDWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGLPGENAGYLTpywL 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  317 EGkvALAETSIGqgkILVTPLTMALVASAVANDGVIMKPYLMRYVADPISGTVIEKstpsqylNPISKKVADTIKQLMIG 396
Cdd:pfam00905 147 EG--ATASFGIG---LTITPLQQAQAYAAIANGGKLVPPHLVKSIEDKVDPKVLNK-------LPISKSTAEKVKDMLRL 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  397 AVNDKEGTGKAAqIPGITVAGKTGTAE--------NPHGAPHAWFVGFAPAENPQIVVSVIVENGG--EGGKVAAPIARD 466
Cdd:pfam00905 215 VVNDGTGTGTAA-VPGYKVAGKTGTAQvagpkgggYYDGAQIGWFVGYAPADNPKYAFAVLIDDPKryYGGKVAAPIFKD 293

                  ..
gi 490535313  467 II 468
Cdd:pfam00905 294 IL 295
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
74-468 8.05e-51

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 182.66  E-value: 8.05e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  74 IEADGSQKREYLDGPAFAQVIGYSRRIYQQ--------------------GNAGIEKAYDRELLGMVG------NDPIII 127
Cdd:PRK10795 157 VEVKGYQRRYYPYGSALTHVIGYVSKINDKdverldkegklanyaathdiGKLGIERYYEDVLHGKTGyeevevNNRGRV 236
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 128 LRKLVLAKGQVGDNVYLTIDKTLQDLAYKEMEGKKGAVVVLNPKTGEILAMVSTPSYDPNTL-----GENWKEIMTSPDN 202
Cdd:PRK10795 237 IRQLHEQPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGILALVSTPSYDPNLFvdgisSKDYSGLLNDPNR 316
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 203 VVLNRATQGLYPPGSVFKIVTTAAVLTYEPELYNKTFDCKGYIIVDGN--RINDFGGIAHGIEDFKQAFYRSCNSFFIQI 280
Cdd:PRK10795 317 PLINRATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSekRYRDWKKWGHGRLNVTKSLEESADTFFYQV 396
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 281 GLDLGSENLQSMAYNFGLDKRVPLEI--DTAKNyFPPIEGKVALAE----------TSIGQGKILVTPLTMALVASAVAN 348
Cdd:PRK10795 397 AYDMGIDRLSEWMGKFGYGHYTGIDLaeERSGN-MPTREWKQKRFKkpwyqgdtipVGIGQGYWTATPIQMSKALMTLIN 475
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 349 DGVIMKPYLMryvadpiSGTViEKSTPSQYLNPISKKVAD-------TIKQLMIGAVNDKEGTGKA--AQIPgITVAGKT 419
Cdd:PRK10795 476 DGIVKVPHLL-------MSTA-EDGKQVPWVQPHEPPVGDihsgyweIAKDGMYGVANRPNGTAHKyfASAP-YKIAAKS 546
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490535313 420 GTAE---------------NPHGAPHAWFVGFAPAENPQIVVSVIVENGGEGGKVAApIARDII 468
Cdd:PRK10795 547 GTAQvfglkanetynahkiAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGT-IMRQIL 609
 
Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
2-474 5.74e-149

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 436.56  E-value: 5.74e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313   2 SNLNRNIKILFGVFSVLFFGLIAYLTYFQIYERDRLITSSYsvyNRRLIEQEKKILRGSILDRNGIVLAKSI----IEAD 77
Cdd:COG0768    8 RLFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAE---ENRIRTVPIPAPRGLIYDRNGNVLATNVpvysLYAD 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  78 GSQ--------------------------------------------------------------KREYLDGPAFAQVIG 95
Cdd:COG0768   85 PEEvkdpeetaeklakllgldpeelrkklkkksrfpvylkrnlspeeaariralklpgvyveaeyKRYYPYGELAAHVLG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  96 YSRRIY---QQGNAGIEKAYDRELLGMVGndpiiILRKLVLAKGQV------------GDNVYLTIDKTLQDLAYKEMEG 160
Cdd:COG0768  165 YVGEINggdGIGKSGLEKAYEDLLRGTPG-----KRRVEVDARGRVirdlgeekppvpGKDLVLTIDSDLQKIAEEALKK 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 161 -------KKGAVVVLNPKTGEILAMVSTPSYDPNTLGEnwkeimtSPDNVVLNRATQGLYPPGSVFKIVTTAAVL---TY 230
Cdd:COG0768  240 aveeykaKSGAVVVMDPKTGEILAMASYPSFDPNLFVG-------GPDEPLRNRAVQGTYEPGSTFKPFTAAAALeegVI 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 231 EPelyNKTFDCKGYIIVDGNRINDFGGIAHGIEDFKQAFYRSCNSFFIQIGLDLGSENLQSMAYNFGLDKRVPLEIDTAK 310
Cdd:COG0768  313 TP---DTTFDCPGYYRVGGRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLYDYLKKFGLGQKTGIDLPGEA 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 311 N-YFPPIE--GKVALAETSIGQGkILVTPLTMALVASAVANDGVIMKPYLMRYVADPISGTVIEKSTPSQYLnpISKKVA 387
Cdd:COG0768  390 SgLLPSPKrwYPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVVKEEPEVLRRV--ISPETA 466
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 388 DTIKQLMIGAVNDKEGTGKAAQIPGITVAGKTGTAENPHGAPH--------AWFVGFAPAENPQIVVSVIVENGGE---G 456
Cdd:COG0768  467 ETVREGMEGVVNEPGGTARRAAIPGYRVAGKTGTAQVVDIGNGgyykgrhiASFVGFAPADNPRYAVAVVVENPGGgayG 546
                        570
                 ....*....|....*...
gi 490535313 457 GKVAAPIARDIIRSYLTK 474
Cdd:COG0768  547 GTVAAPVFREIMEAYLRL 564
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
6-474 1.01e-126

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 380.72  E-value: 1.01e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313    6 RNIKILFGVFSVLFFGLIAYLTYFQIYERDRLITSSYSvyNRRlieQEKKIL--RGSILDRNGIVLAKSI---------- 73
Cdd:TIGR03423   1 RRALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSED--NRI---RLVPIPppRGLILDRNGVLLADNRpsfsleivpe 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313   74 --------------------------------------------------------------IEADGSQKREYLDGPAFA 91
Cdd:TIGR03423  76 kvddldatldrlaklldldpediarflkelkrsrrfepiplksdlteeevarfavnqyrlpgVEIEARLKRYYPYGELAA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313   92 QVIGYSRRIYQQ----------------GNAGIEKAYDRELLGMVGndpiiILRKLVLAKGQV-----------GDNVYL 144
Cdd:TIGR03423 156 HVLGYVGEINEEdlerlepanyaggdyiGKSGIEKYYEDELRGKPG-----YREVEVNARGRVirtlsrvppvpGKDLVL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  145 TIDKTLQDLAYKEMEGKKGAVVVLNPKTGEILAMVSTPSYDPNTL-----GENWKEIMTSPDNVVLNRATQGLYPPGSVF 219
Cdd:TIGR03423 231 TIDARLQQAAEKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFvdgisSKDYKALLNDPDRPLLNRAIQGVYPPGSTF 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  220 KIVTTAAVL---TYEPElynKTFDCKGYIIVDGNRINDFGGIAHGIEDFKQAFYRSCNSFFIQIGLDLGSENLQSMAYNF 296
Cdd:TIGR03423 311 KPVVALAALeegVITPE---TRIYCPGYFQLGGRRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRF 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  297 GLDKRVPLEI---------DTA-------KNYFPpiegkvalAET---SIGQGKILVTPLTMALVASAVANDGVIMKPYL 357
Cdd:TIGR03423 388 GFGQKTGIDLpgeksglvpSREwkrkrfgQPWYP--------GDTlnvSIGQGYVLVTPLQLAVATAALANGGKLYKPHL 459
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  358 MRYVADPISGTVIEKSTPSQYLNPISKKVADTIKQLMIGAVNDKEGTGKAAQIP-GITVAGKTGTAE----------NPH 426
Cdd:TIGR03423 460 VKSIEDPDGGVVRRTEPEVLRPLPISPENLDVVREGMRDVVNGPGGTARRARLGlPYKMAGKTGTAQvvslkqgekyDAE 539
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|...
gi 490535313  427 GAP-----HAWFVGFAPAENPQIVVSVIVENGGEGGKVAAPIARDIIRSYLTK 474
Cdd:TIGR03423 540 QIPerlrdHALFVAFAPYDNPKIAVAVIVEHGGGGSSAAAPIARKIMDAYLLG 592
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
163-468 2.57e-73

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 233.08  E-value: 2.57e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  163 GAVVVLNPKTGEILAMVSTPSYDPNTLGENWkeimtspdnvvLNRATQGLYPPGSVFKIVTTAAVL---TYEPelyNKTF 239
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFIGPL-----------RNRAVTSRYEPGSTFKPFTALAALdngVLKP---DETI 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  240 DCKGYIIVDGNRINDFGGIAHGIEDFKQAFYRSCNSFFIQIGLDLGSENLQSMAYNFGLDKRVPLEIDTAKNYFPP---I 316
Cdd:pfam00905  67 FDWPGKQQGGKSIGDWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGLPGENAGYLTpywL 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  317 EGkvALAETSIGqgkILVTPLTMALVASAVANDGVIMKPYLMRYVADPISGTVIEKstpsqylNPISKKVADTIKQLMIG 396
Cdd:pfam00905 147 EG--ATASFGIG---LTITPLQQAQAYAAIANGGKLVPPHLVKSIEDKVDPKVLNK-------LPISKSTAEKVKDMLRL 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  397 AVNDKEGTGKAAqIPGITVAGKTGTAE--------NPHGAPHAWFVGFAPAENPQIVVSVIVENGG--EGGKVAAPIARD 466
Cdd:pfam00905 215 VVNDGTGTGTAA-VPGYKVAGKTGTAQvagpkgggYYDGAQIGWFVGYAPADNPKYAFAVLIDDPKryYGGKVAAPIFKD 293

                  ..
gi 490535313  467 II 468
Cdd:pfam00905 294 IL 295
spoVD_pbp TIGR02214
stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the ...
30-472 2.93e-73

stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the cell division protein FtsI, a penicillin binding protein. This subfamily is restricted to Bacillus subtilis and related Gram-positive species with known or suspected endospore formation capability. In these species, the functional equivalent of FtsI is desginated PBP-2B, a paralog of spoVD. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination]


Pssm-ID: 131269 [Multi-domain]  Cd Length: 636  Bit Score: 243.18  E-value: 2.93e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313   30 QIYERdrlITSSYSVYN----RRLIEQEK-KILRGsiLDRNGIVLAKSiieadgsQKREYLDGPAFAQVIGYSRRiYQQG 104
Cdd:TIGR02214 101 KVFKR---ITKKNSPFVsaklGRKIEKDKaEKVRN--LKLNGVSVSPD-------SKRYYPNGDFLSHVLGFTNS-DGRG 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  105 NAGIEKAYDRELLGMVGndpiiILRKLVLAKGQ-------------VGDNVYLTIDKTLQDLAYKEME-------GKKGA 164
Cdd:TIGR02214 168 LEGLELYYDKELRGLPG-----VRVAEYDANSLelpyaqhayvkpvDGHDLVLTIDENIQYIIEREADkalrerkPKGVS 242
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  165 VVVLNPKTGEILAMVSTPSYDPNtlgENWKEimtSPDNVVLNRATQGLYPPGSVFKIVTTAAVLTYEPELYNKTFDCKGY 244
Cdd:TIGR02214 243 IIVMNPKNGEILGMSNRPTYDPN---DPRDK---SPDTARRNRAVSDAYEPGSTFKIITSSAAMEEGIVKESDKFYDDGS 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  245 IIVDGNRINDFGGIAHGIEDFKQAFYRSCNSFFIQIGLDLGSENLQSMAYNFGLDKRVPLEID-TAKNYFPPIE--GKVA 321
Cdd:TIGR02214 317 ATVGGKKIKCWKPGGHGSQTFPEVVQNSCNPGFIELGMRLGAEKLNNYILAFGFGSKTGIDLPgEAAGILVPKKkvGPVD 396
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  322 LAETSIGQGKIlVTPLTMALVASAVANDGVIMKPYLMRYVADPISGTVIEKSTPSQYLNPISKKVADTIKQLMIGAVNdk 401
Cdd:TIGR02214 397 LATISFGQANT-VTPIQLMTAVNAVANGGKLIQPHIMKEISDSQNNAVDQTFEPEVKRQVVSKETTQKLRLALETVVS-- 473
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  402 EGTGKAAQIPGITVAGKTGTAENP-------HGAPHAWFVGFAPAENPQIVVSVIVEN--GGE--GGKVAAPIARDIIRS 470
Cdd:TIGR02214 474 KGSGKNAFIEGYRVGGKTGTAQKVkpnggymEGEYIVSFVGFAPADDPAVAVLVVVDNpkGVQqfGGLVAAPVFGSVFND 553

                  ..
gi 490535313  471 YL 472
Cdd:TIGR02214 554 IL 555
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
74-468 8.05e-51

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 182.66  E-value: 8.05e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  74 IEADGSQKREYLDGPAFAQVIGYSRRIYQQ--------------------GNAGIEKAYDRELLGMVG------NDPIII 127
Cdd:PRK10795 157 VEVKGYQRRYYPYGSALTHVIGYVSKINDKdverldkegklanyaathdiGKLGIERYYEDVLHGKTGyeevevNNRGRV 236
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 128 LRKLVLAKGQVGDNVYLTIDKTLQDLAYKEMEGKKGAVVVLNPKTGEILAMVSTPSYDPNTL-----GENWKEIMTSPDN 202
Cdd:PRK10795 237 IRQLHEQPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGILALVSTPSYDPNLFvdgisSKDYSGLLNDPNR 316
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 203 VVLNRATQGLYPPGSVFKIVTTAAVLTYEPELYNKTFDCKGYIIVDGN--RINDFGGIAHGIEDFKQAFYRSCNSFFIQI 280
Cdd:PRK10795 317 PLINRATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSekRYRDWKKWGHGRLNVTKSLEESADTFFYQV 396
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 281 GLDLGSENLQSMAYNFGLDKRVPLEI--DTAKNyFPPIEGKVALAE----------TSIGQGKILVTPLTMALVASAVAN 348
Cdd:PRK10795 397 AYDMGIDRLSEWMGKFGYGHYTGIDLaeERSGN-MPTREWKQKRFKkpwyqgdtipVGIGQGYWTATPIQMSKALMTLIN 475
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 349 DGVIMKPYLMryvadpiSGTViEKSTPSQYLNPISKKVAD-------TIKQLMIGAVNDKEGTGKA--AQIPgITVAGKT 419
Cdd:PRK10795 476 DGIVKVPHLL-------MSTA-EDGKQVPWVQPHEPPVGDihsgyweIAKDGMYGVANRPNGTAHKyfASAP-YKIAAKS 546
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490535313 420 GTAE---------------NPHGAPHAWFVGFAPAENPQIVVSVIVENGGEGGKVAApIARDII 468
Cdd:PRK10795 547 GTAQvfglkanetynahkiAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGT-IMRQIL 609
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
139-472 1.50e-50

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 181.66  E-value: 1.50e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 139 GDNVYLTIDKTLQDLAYK---------EMEGKKGAVVVLNPKTGEILAMVSTPSYDPNTLgenwkeimtspdnvvlNRAT 209
Cdd:COG0744  294 GLKIYTTLDPKLQKAAEKavknvlpegKPGGLQAALVVVDPKTGEVLAMVGGRDYGKSQF----------------NRAT 357
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 210 QGLYPPGSVFKIVTTAAVLT--YEPelyNKTFDCKGYIIVDGN-RINDFGGIAHGIEDFKQAFYRSCNSFFIQIGLDLGS 286
Cdd:COG0744  358 QAKRQPGSTFKPFVYAAALEqgYTP---ATTVDDEPVTFPGGGwSPKNYDGRYRGPVTLREALANSLNTPAVRLAQEVGL 434
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 287 ENLQSMAYNFGldkrvpleIDTAKNYFPPIegkvALaetsigqGKILVTPLTMALVASAVANDGVIMKPYLMRYVADPiS 366
Cdd:COG0744  435 DKVVDTARRLG--------ITSPLDPNPSL----AL-------GTSEVSPLEMASAYATFANGGVYVEPHAITKVTDA-D 494
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 367 GTVIEKSTPSQYlNPISKKVADTIKQLMIGAVNdkEGTGKAAQIPGITVAGKTGTAENphgAPHAWFVGFapaeNPQIVV 446
Cdd:COG0744  495 GKVLYEAKPKCE-QVISPEVAYLMTDMLQDVVT--SGTGRAARLPGRPVAGKTGTTND---NRDAWFVGY----TPQLVT 564
                        330       340       350
                 ....*....|....*....|....*....|...
gi 490535313 447 SVIVEN-------GGEGGKVAAPIARDIIRSYL 472
Cdd:COG0744  565 AVWVGNddnspmgYVTGGSLPAPIWRDFMEAAL 597
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
142-472 2.09e-37

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 143.55  E-value: 2.09e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  142 VYLTIDKTLQDLAYKEMEGKK------------GAVVVLNPKTGEILAMVSTPSYDPNTLgenwkeimtspdnvvlNRAT 209
Cdd:TIGR02074 224 IYTTLDLDAQKAAEKVLNTGLrvagrrdgddlqAALVAIDPDTGAVRALVGGRDYGKSQF----------------NRAT 287
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  210 QGLYPPGSVFKIVTTAAVLTY----------EPELYNKTfdcKGYIIvdgnriNDFGGIAHGIEDFKQAFYRSCNSFFIQ 279
Cdd:TIGR02074 288 QAKRQPGSTFKPFVYAAALEKgltpativndEPITYNGN---GPWSP------KNYGGGYRGNVTLRQALAQSRNIPAVR 358
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  280 IGLDLGSENLQSMAYNFGldkrvpleIDTAKNYFPPIegkvALaetsigqGKILVTPLTMALVASAVANDGVIMKPYLMR 359
Cdd:TIGR02074 359 LLQEVGLDKVVALAKRFG--------ITSPLDPVLSL----AL-------GTVEVSPLEMASAYAVFANGGKYVEPHGIR 419
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  360 YVADPiSGTVIEKSTPSQYlNPISKKVADTIKQLMIGAVNdkEGTGKAAQIPGITVAGKTGTAENphgAPHAWFVGFapa 439
Cdd:TIGR02074 420 KIVDR-DGKVIYENKPKTT-QVISPATAYIMTDMLKGVVE--SGTGRSARLPGRPVAGKTGTTQN---WRDAWFVGY--- 489
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 490535313  440 eNPQIVVSVIVEN--------GGEGGKVAAPIARDIIRSYL 472
Cdd:TIGR02074 490 -TPYYVTAVWVGYddkktlgkSGTGGGLAAPIWRDFMAEAL 529
PRK15105 PRK15105
peptidoglycan synthase FtsI; Provisional
81-463 1.16e-28

peptidoglycan synthase FtsI; Provisional


Pssm-ID: 185060 [Multi-domain]  Cd Length: 578  Bit Score: 119.15  E-value: 1.16e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313  81 KREYLDGPAFAQVIGYSRrIYQQGNAGIEKAYDRELLGMVGNDpiiILRK---------LVLAKGQVGDNVYLTIDKTLQ 151
Cdd:PRK15105 165 RRYYPSGEVTAHLIGFTN-VDSQGIEGVEKSFDKWLTGQPGER---IVRKdrygrviedISSTDSQAAHNLALSIDERLQ 240
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 152 DLAYKEM-------EGKKGAVVVLNPKTGEILAMVSTPSYDPNTLGENWKEIMTspdnvvlNRATQGLYPPGSVFKIVTT 224
Cdd:PRK15105 241 ALVYRELnnavafnKAESGSAVLVDVNTGEVLAMANSPSYNPNNLSGTPKDAMR-------NRAITDVFEPGSTVKPMVV 313
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 225 AAVLTYEPELYNKTFDCKGYIIvDGNRINDFGGIAH----GIedfkqaFYRSCNSFFIQIGLDLGSENLQSMAYNFGLDK 300
Cdd:PRK15105 314 MTALQRGVVKENSVLNTVPYRI-NGHEIKDVARYSEltltGV------LQKSSNVGVSKLALAMPSSALVDTYSRFGLGK 386
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 301 RVPLE-IDTAKNYFPPIE--GKVALAETSIGQGkILVTPLTMALVASAVANDGvIMKPYLMRYVADPISGTVIekstpsq 377
Cdd:PRK15105 387 ATNLGlVGERSGLYPQKQrwSDIERATFSFGYG-LMVTPLQLARVYATIGSYG-IYRPLSITKVDPPVPGERV------- 457
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 378 YLNPISKKVADtikqlMIGAVNDKEGTGKAAQIPGITVAGKTGTAEN--PHG----APHAWFVGFAPAENPQIVVSVIVE 451
Cdd:PRK15105 458 FPESIVRTVVH-----MMESVALPGGGGVKAAIKGYRIAIKTGTAKKvgPDGryinKYIAYTAGVAPASQPRFALVVVIN 532
                        410
                 ....*....|....*.
gi 490535313 452 N--GGE--GGKVAAPI 463
Cdd:PRK15105 533 DpqAGKyyGGAVSAPV 548
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
163-472 9.03e-27

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 114.10  E-value: 9.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 163 GAVVVLNPKTGEILAMVSTPSYDPNtlgenwkeimtspdnvVLNRATQGLYPPGSVFK-IVTTAAvltyepelynktFDc 241
Cdd:COG5009  423 GALVALDPHTGAVLALVGGFDFEQS----------------KFNRATQAKRQPGSSFKpFVYAAA------------LD- 473
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 242 KGY----IIVD----------GN--RINDFGGIAHGIEDFKQAFYRSCNSFFIQIGLDLGSENLQSMAYNFGLDKRVPle 305
Cdd:COG5009  474 NGYtpatIINDapivfddgggGGvwRPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYVIDYAERFGIYSKLP-- 551
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 306 idtakNYFPpiegkVALaetsigqGKILVTPLTMALVASAVANDGVIMKPYLMRYVADPiSGTVIEKSTPSQYLNP---- 381
Cdd:COG5009  552 -----PNLS-----LAL-------GSGEVTPLEMARAYAVFANGGYRVEPYLIDRIEDR-NGKVIYRADPARACEDcdaa 613
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490535313 382 ----------------ISKKVADTIKQLMIGAVndKEGTGKAAQIPGITVAGKTGTAENPHgapHAWFVGFapaeNPQIV 445
Cdd:COG5009  614 ewdgaeprlpdpaeqvIDPRTAYQMTSMLRGVV--QRGTGRRARALGRDIAGKTGTTNDSK---DAWFVGF----TPDLV 684
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 490535313 446 VSVIV--------ENGGEGGKVAAPIARDIIRSYL 472
Cdd:COG5009  685 AGVWVgfddprslGRGETGGRAALPIWIDFMKAAL 719
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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