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Conserved domains on  [gi|490578846|ref|WP_004443866|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Agrobacterium]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-142 1.24e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.35  E-value: 1.24e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846   3 TKRERDSLAFLLNSGARLLNSAFERRISEagLGLTPGEARALLTVAVVDGSKQSDIAARLGIEPMTICAYLDKLQSLNLI 82
Cdd:COG1846    5 PDPAEERLGLLLRRLARALRRALDRALAE--LGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846  83 ERQQDPQDRRSKRIVLTKSSADMLEAVRQEIDELVRHATQGLNDEEVALFRHFLQTLRDN 142
Cdd:COG1846   83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-142 1.24e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.35  E-value: 1.24e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846   3 TKRERDSLAFLLNSGARLLNSAFERRISEagLGLTPGEARALLTVAVVDGSKQSDIAARLGIEPMTICAYLDKLQSLNLI 82
Cdd:COG1846    5 PDPAEERLGLLLRRLARALRRALDRALAE--LGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846  83 ERQQDPQDRRSKRIVLTKSSADMLEAVRQEIDELVRHATQGLNDEEVALFRHFLQTLRDN 142
Cdd:COG1846   83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
34-129 3.93e-17

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 71.86  E-value: 3.93e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846    34 LGLTPGEARALLTVAVVDGSKQSDIAARLGIEPMTICAYLDKLQSLNLIERQQDPQDRRSKRIVLTKSSADMLEAVRQEI 113
Cdd:smart00347   6 LGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEAR 85

                           90
                   ....*....|....*.
gi 490578846   114 DELVRHATQGLNDEEV 129
Cdd:smart00347  86 SETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 34-93 1.87e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 53.36  E-value: 1.87e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846   34 LGLTPGEARALLTVAVVDGSKQSDIAARLGIEPMTICAYLDKLQSLNLIERQQDPQDRRS 93
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 51-144 2.23e-09

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 52.70  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846  51 DGSKQSDIAARLGIEPMTICAYLDKLQSLNLIERQQDPQDRRSKRIVLTKSSADMLEAVRQEIDELVRHATQGLNDEEVA 130
Cdd:PRK03573  45 PEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIE 124

                         90
                 ....*....|....
gi 490578846 131 LFRHFLQTLRDNLQ 144
Cdd:PRK03573 125 QLITLIAKLEKNII 138
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-142 1.24e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.35  E-value: 1.24e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846   3 TKRERDSLAFLLNSGARLLNSAFERRISEagLGLTPGEARALLTVAVVDGSKQSDIAARLGIEPMTICAYLDKLQSLNLI 82
Cdd:COG1846    5 PDPAEERLGLLLRRLARALRRALDRALAE--LGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846  83 ERQQDPQDRRSKRIVLTKSSADMLEAVRQEIDELVRHATQGLNDEEVALFRHFLQTLRDN 142
Cdd:COG1846   83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
34-129 3.93e-17

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 71.86  E-value: 3.93e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846    34 LGLTPGEARALLTVAVVDGSKQSDIAARLGIEPMTICAYLDKLQSLNLIERQQDPQDRRSKRIVLTKSSADMLEAVRQEI 113
Cdd:smart00347   6 LGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEAR 85

                           90
                   ....*....|....*.
gi 490578846   114 DELVRHATQGLNDEEV 129
Cdd:smart00347  86 SETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 34-93 1.87e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 53.36  E-value: 1.87e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846   34 LGLTPGEARALLTVAVVDGSKQSDIAARLGIEPMTICAYLDKLQSLNLIERQQDPQDRRS 93
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 51-144 2.23e-09

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 52.70  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846  51 DGSKQSDIAARLGIEPMTICAYLDKLQSLNLIERQQDPQDRRSKRIVLTKSSADMLEAVRQEIDELVRHATQGLNDEEVA 130
Cdd:PRK03573  45 PEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIE 124

                         90
                 ....*....|....
gi 490578846 131 LFRHFLQTLRDNLQ 144
Cdd:PRK03573 125 QLITLIAKLEKNII 138
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-94 3.29e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 49.85  E-value: 3.29e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 490578846   36 LTPGEARALLTVAVVDGSKQSDIAARLGIEPMTICAYLDKLQSLNLIERQQDPQDRRSK 94
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
YrhO COG1378
Sugar-specific transcriptional regulator TrmB [Transcription];
34-118 2.41e-04

Sugar-specific transcriptional regulator TrmB [Transcription];


Pssm-ID: 440988 [Multi-domain]  Cd Length: 238  Bit Score: 39.62  E-value: 2.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846  34 LGLTPGEARALLTVAVVDGSKQSDIAARLGIEPMTICAYLDKLQSLNLIERQQDpqdrRSKRIV----------LTKSSA 103
Cdd:COG1378    9 LGLSEYEAKVYLALLELGPATASELAKASGVPRSRVYDVLESLEEKGLVEVSEG----RPKRYRavppeealerLLEERE 84

                         90
                 ....*....|....*
gi 490578846 104 DMLEAVRQEIDELVR 118
Cdd:COG1378   85 EELEELREELEELYE 99
HTH_27 pfam13463
Winged helix DNA-binding domain;
36-99 5.22e-04

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 36.50  E-value: 5.22e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490578846   36 LTPGEARALLTVAVV-DGSKQSDIAARLGIEPMTICAYLDKLQSLNLIERQQDPQDRRSKRIVLT 99
Cdd:pfam13463   1 LTRLEALILHNIGHRgDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLT 65
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
62-137 7.79e-04

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 37.57  E-value: 7.79e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490578846  62 LGIEPMTICAYLDKLQSLNLIERQQDPQDRRSKRIVLTKSSADMLEAVRQEI-DELVRHATQGLNDEEVALFRHFLQ 137
Cdd:PRK11512  64 LSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCHQLVgQDLHQELTKNLTADEVATLEHLLK 140
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
27-128 1.82e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 36.48  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846  27 RRISEAGLGLTPGEARALLTVavVDGSKQS---DIAARLGIEPMTICAYLDKLQSLNLIERQQDPQDRRSKRIVLT-KSS 102
Cdd:COG3355   16 EDVLECVYGLSETDAEVYLIL--LENGEPLtveELAEALDRSRSTVYRSLQKLLEAGLVEREKRNLEGGGYPYVYYaIDP 93

                         90       100
                 ....*....|....*....|....*.
gi 490578846 103 ADMLEAVRQEIDELVRHATQGLNDEE 128
Cdd:COG3355   94 EELKEKLVDDLDEWYEKVGELIEEFE 119
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
24-141 5.54e-03

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 35.29  E-value: 5.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490578846  24 AFERRISEAGLGLTPGEARALLTVAvvDGSK-QSDIAARLGIEPMTICAYLDKLQSLNLIERQQDPQDRR----SKRIVL 98
Cdd:COG1510   15 AFGEMGERWGLPRSAGRIYALLYLS--DEPLtADELAEELGVSKSSVSTALRELEDWGLVRRVRKPGDRKdyfrAEKDVW 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 490578846  99 TKSSADMLEAVRQEIDELVRHATQGLN----DEEVALFRHFLQTLRD 141
Cdd:COG1510   93 ELFRRVFRERLRREIDPTLELLREALEeledSEEAEEARERLEELRD 139
COG1672 COG1672
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
48-95 6.27e-03

Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];


Pssm-ID: 441278 [Multi-domain]  Cd Length: 324  Bit Score: 35.66  E-value: 6.27e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 490578846  48 AVVDG-SKQSDIAARLGIEPMTICAYLDKLQSLNLIERQQDPqdRRSKR 95
Cdd:COG1672  253 AIASGaTRLSEIASALGISSSSLSRYLKNLIDLGIIEKEVPV--EKSKK 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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