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Conserved domains on  [gi|490589022|ref|WP_004454042|]
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serine dehydratase subunit alpha family protein [Clostridioides difficile]

Protein Classification

serine dehydratase subunit alpha family protein( domain architecture ID 10007829)

serine dehydratase subunit alpha family protein such as L-cysteine desulfidase, which catalyzes the cleavage of L-cysteine to form 2-aminoprop-2-enoate and sulfide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CdsB COG3681
L-cysteine desulfidase YhaM [Amino acid transport and metabolism];
1-433 0e+00

L-cysteine desulfidase YhaM [Amino acid transport and metabolism];


:

Pssm-ID: 442897  Cd Length: 429  Bit Score: 540.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022   1 MRDIRKELVEMLKAEVKPAVGCTEPVALALACAKAKELLGEEIVENRMLVSPSIYKNGMCVGIPGTERLGLKIAAALGIV 80
Cdd:COG3681    2 DTELYQTLIEILKEEVVPALGCTEPIAVALAAAKAREVLGGEPEKIEVKVSGNIYKNGMGVGIPGTGMKGLEIAAALGAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022  81 GGHSENGLSVLETLTKEEVKIAEDYMDNTPLSITPADTREKVFIEVVLKGKNHIAKVRIRTKHDNFTFLEKDGEVLLDNE 160
Cdd:COG3681   82 GGDPEKGLEVLKDVTPEDVEKAKELLDEGRVTVELKETDEGLYIEATVKTGDHSARVVIEGSHTNIVLIEKNGEVLFEKE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022 161 PKVSASNDAAEKAESLmdtvTIQELIKNVEGIDFKDIEFLLDGVKMNEEMAEYGLKQKTGIGVGYGIKKSIEEGLLGNDV 240
Cdd:COG3681  162 SSAASEESLLEDLKKL----SIKDIYDFAEEVDLEDIAFILEGIEMNMAIAEEGLKGKYGLGIGKTLLKQIEKGLLGDDL 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022 241 INYAMMLTAGASDARMAGVKMPVMSSNGSGNHGLTAILPIVAYNKKFPQSDERLAKALAISHLVTGYIKNYTGRLSAVCG 320
Cdd:COG3681  238 LSRARALTAAASDARMSGCPLPVMSNSGSGNQGITATLPVVVYAEHLGASEEKLARALALSHLVTIYIKSYIGRLSALCG 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022 321 CGVAAsTGATAGISWLMNGTEKQIEGAIENMIADLSGMICDGAKAGCALKLSSAASAAIQSAIIAKQDCFVPPLNGIVGS 400
Cdd:COG3681  318 AVVAG-AGAAAGIAYLLGGDYEQIEGAIKNMLANLSGMICDGAKPSCALKVSTAVSAAILAALMALDGIVVTGGDGIVGE 396

                        410       420       430
                 ....*....|....*....|....*....|...
gi 490589022 401 SVEQSIQNLGRVSDKGMSITDEIILNVMNDMNK 433
Cdd:COG3681  397 DVEETIRNLGRLASEGMKETDKEILEIMLKKQK 429
 
Name Accession Description Interval E-value
CdsB COG3681
L-cysteine desulfidase YhaM [Amino acid transport and metabolism];
1-433 0e+00

L-cysteine desulfidase YhaM [Amino acid transport and metabolism];


Pssm-ID: 442897  Cd Length: 429  Bit Score: 540.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022   1 MRDIRKELVEMLKAEVKPAVGCTEPVALALACAKAKELLGEEIVENRMLVSPSIYKNGMCVGIPGTERLGLKIAAALGIV 80
Cdd:COG3681    2 DTELYQTLIEILKEEVVPALGCTEPIAVALAAAKAREVLGGEPEKIEVKVSGNIYKNGMGVGIPGTGMKGLEIAAALGAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022  81 GGHSENGLSVLETLTKEEVKIAEDYMDNTPLSITPADTREKVFIEVVLKGKNHIAKVRIRTKHDNFTFLEKDGEVLLDNE 160
Cdd:COG3681   82 GGDPEKGLEVLKDVTPEDVEKAKELLDEGRVTVELKETDEGLYIEATVKTGDHSARVVIEGSHTNIVLIEKNGEVLFEKE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022 161 PKVSASNDAAEKAESLmdtvTIQELIKNVEGIDFKDIEFLLDGVKMNEEMAEYGLKQKTGIGVGYGIKKSIEEGLLGNDV 240
Cdd:COG3681  162 SSAASEESLLEDLKKL----SIKDIYDFAEEVDLEDIAFILEGIEMNMAIAEEGLKGKYGLGIGKTLLKQIEKGLLGDDL 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022 241 INYAMMLTAGASDARMAGVKMPVMSSNGSGNHGLTAILPIVAYNKKFPQSDERLAKALAISHLVTGYIKNYTGRLSAVCG 320
Cdd:COG3681  238 LSRARALTAAASDARMSGCPLPVMSNSGSGNQGITATLPVVVYAEHLGASEEKLARALALSHLVTIYIKSYIGRLSALCG 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022 321 CGVAAsTGATAGISWLMNGTEKQIEGAIENMIADLSGMICDGAKAGCALKLSSAASAAIQSAIIAKQDCFVPPLNGIVGS 400
Cdd:COG3681  318 AVVAG-AGAAAGIAYLLGGDYEQIEGAIKNMLANLSGMICDGAKPSCALKVSTAVSAAILAALMALDGIVVTGGDGIVGE 396

                        410       420       430
                 ....*....|....*....|....*....|...
gi 490589022 401 SVEQSIQNLGRVSDKGMSITDEIILNVMNDMNK 433
Cdd:COG3681  397 DVEETIRNLGRLASEGMKETDKEILEIMLKKQK 429
SDH_alpha pfam03313
Serine dehydratase alpha chain; L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer ...
 179-426 3.18e-58

Serine dehydratase alpha chain; L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyzes the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.


Pssm-ID: 427238  Cd Length: 259  Bit Score: 191.47  E-value: 3.18e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022  179 TVTIQELIKNVEGIDfkdiEFLLDGVKMNEEMAEYGLkqktgIGVGYGIKKSIEEGLLGNDVINYAMmlTAGASDARMAG 258
Cdd:pfam03313  21 LLSAEEVDAKLEDIW----EFMLEAIEMNLAISEEGL-----LPGGLKVRRRNYGLGLGGTLLDKAL--AAAAADARMNG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022  259 VKMPVMSSNGSGNHGltaILPIVAYNKKFPQSDERLAKALAISHLVTGYIKNYTGRLSAVCGCGVAASTG---ATAGISW 335
Cdd:pfam03313  90 AMGPVVTAPTSGNQG---ILPAVLYAEELGASEEKLIRALLLSALIGIYIKKNAGILSAECGCQAEVGSAsamAAAGLAY 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022  336 LMNGTEKQIEGAIENMIADLSGMICDG----AKAGCALKLSSAASAAIQSAIIAKQDcfvPPLNGIVG-SSVEQSIQNLG 410
Cdd:pfam03313 167 LLGGTPEQIENAAENALENLLGLICDPvaglVKVPCAEKNATGAVAAILAALMALAG---DGIDGIVPlDEVIETMRNVG 243

                         250
                  ....*....|....*.
gi 490589022  411 RVSDKGMSITDEIILN 426
Cdd:pfam03313 244 RLMPEGMKETDLGGLA 259
 
Name Accession Description Interval E-value
CdsB COG3681
L-cysteine desulfidase YhaM [Amino acid transport and metabolism];
1-433 0e+00

L-cysteine desulfidase YhaM [Amino acid transport and metabolism];


Pssm-ID: 442897  Cd Length: 429  Bit Score: 540.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022   1 MRDIRKELVEMLKAEVKPAVGCTEPVALALACAKAKELLGEEIVENRMLVSPSIYKNGMCVGIPGTERLGLKIAAALGIV 80
Cdd:COG3681    2 DTELYQTLIEILKEEVVPALGCTEPIAVALAAAKAREVLGGEPEKIEVKVSGNIYKNGMGVGIPGTGMKGLEIAAALGAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022  81 GGHSENGLSVLETLTKEEVKIAEDYMDNTPLSITPADTREKVFIEVVLKGKNHIAKVRIRTKHDNFTFLEKDGEVLLDNE 160
Cdd:COG3681   82 GGDPEKGLEVLKDVTPEDVEKAKELLDEGRVTVELKETDEGLYIEATVKTGDHSARVVIEGSHTNIVLIEKNGEVLFEKE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022 161 PKVSASNDAAEKAESLmdtvTIQELIKNVEGIDFKDIEFLLDGVKMNEEMAEYGLKQKTGIGVGYGIKKSIEEGLLGNDV 240
Cdd:COG3681  162 SSAASEESLLEDLKKL----SIKDIYDFAEEVDLEDIAFILEGIEMNMAIAEEGLKGKYGLGIGKTLLKQIEKGLLGDDL 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022 241 INYAMMLTAGASDARMAGVKMPVMSSNGSGNHGLTAILPIVAYNKKFPQSDERLAKALAISHLVTGYIKNYTGRLSAVCG 320
Cdd:COG3681  238 LSRARALTAAASDARMSGCPLPVMSNSGSGNQGITATLPVVVYAEHLGASEEKLARALALSHLVTIYIKSYIGRLSALCG 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022 321 CGVAAsTGATAGISWLMNGTEKQIEGAIENMIADLSGMICDGAKAGCALKLSSAASAAIQSAIIAKQDCFVPPLNGIVGS 400
Cdd:COG3681  318 AVVAG-AGAAAGIAYLLGGDYEQIEGAIKNMLANLSGMICDGAKPSCALKVSTAVSAAILAALMALDGIVVTGGDGIVGE 396

                        410       420       430
                 ....*....|....*....|....*....|...
gi 490589022 401 SVEQSIQNLGRVSDKGMSITDEIILNVMNDMNK 433
Cdd:COG3681  397 DVEETIRNLGRLASEGMKETDKEILEIMLKKQK 429
SDH_alpha pfam03313
Serine dehydratase alpha chain; L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer ...
 179-426 3.18e-58

Serine dehydratase alpha chain; L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyzes the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.


Pssm-ID: 427238  Cd Length: 259  Bit Score: 191.47  E-value: 3.18e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022  179 TVTIQELIKNVEGIDfkdiEFLLDGVKMNEEMAEYGLkqktgIGVGYGIKKSIEEGLLGNDVINYAMmlTAGASDARMAG 258
Cdd:pfam03313  21 LLSAEEVDAKLEDIW----EFMLEAIEMNLAISEEGL-----LPGGLKVRRRNYGLGLGGTLLDKAL--AAAAADARMNG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022  259 VKMPVMSSNGSGNHGltaILPIVAYNKKFPQSDERLAKALAISHLVTGYIKNYTGRLSAVCGCGVAASTG---ATAGISW 335
Cdd:pfam03313  90 AMGPVVTAPTSGNQG---ILPAVLYAEELGASEEKLIRALLLSALIGIYIKKNAGILSAECGCQAEVGSAsamAAAGLAY 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022  336 LMNGTEKQIEGAIENMIADLSGMICDG----AKAGCALKLSSAASAAIQSAIIAKQDcfvPPLNGIVG-SSVEQSIQNLG 410
Cdd:pfam03313 167 LLGGTPEQIENAAENALENLLGLICDPvaglVKVPCAEKNATGAVAAILAALMALAG---DGIDGIVPlDEVIETMRNVG 243

                         250
                  ....*....|....*.
gi 490589022  411 RVSDKGMSITDEIILN 426
Cdd:pfam03313 244 RLMPEGMKETDLGGLA 259
SdaA COG1760
L-serine deaminase [Amino acid transport and metabolism];
263-361 3.71e-06

L-serine deaminase [Amino acid transport and metabolism];


Pssm-ID: 441366 [Multi-domain]  Cd Length: 275  Bit Score: 48.28  E-value: 3.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589022 263 VMSSNGSGnHG----LTA----ILPIV--AYNKKFPQSDERLAKALAISHLVtGYIKNYTGRLS-AVCGC----GVAAST 327
Cdd:COG1760   93 SFEENAAG-GGtvtaPTAgalgVIPAVllYYQEFLGADDERIRDALLTAAAI-GILIKFTASISgAEGGCqaevGSASAM 170

                         90       100       110
                 ....*....|....*....|....*....|....
gi 490589022 328 GAtAGISWLMNGTEKQIEGAIENMIADLSGMICD 361
Cdd:COG1760  171 AA-ASLVELLGGGPIQIENAAEIALEHILGLTCD 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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