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Conserved domains on  [gi|490589345|ref|WP_004454365|]
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B3/4 domain-containing protein [Clostridioides difficile]

Protein Classification

B3/4 domain-containing protein( domain architecture ID 10007291)

B3/4 domain-containing protein may bind DNA/RNA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
B3/B4 COG3382
B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only] ...
1-232 1.35e-91

B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only];


:

Pssm-ID: 442609 [Multi-domain]  Cd Length: 233  Bit Score: 268.65  E-value: 1.35e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345   1 MKFIVEKEVFDKLENVCFGVVVAKGIDNTKEIERISNLLDISIDRVEDYFKDKKVKESEEIIPYREAFRSLGMNPNKFMS 80
Cdd:COG3382    1 MKFSIDPEVFELFPGLRIGVIVAKGVDNTESPPELEALLQEAEEEARARLTLEPLKELPVIAAWREAYKKFGIDPKRYRP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345  81 SIEAMTTRVAKNKKLPHINPIVDLGNSISLKYLLPMGAHDMDFRNDDVYVRFSKKGDKFVPFGETDVELMEEGELIYSVG 160
Cdd:COG3382   81 SAEALLRRVLKGGGLPRINPLVDLYNAVSLRYLLPIGGYDLDKIEGDLRLRLARGGESFLPIGGDEEEPPEPGEVVYADD 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490589345 161 DMVKTRRWIWRQGEEGKITNSSKNIFFPIDGFTDANLDKVMSAREELAKLLKEIFNCE-IKVGFVDKDNPEME 232
Cdd:COG3382  161 EGVFCRRWPWRDSERTKVTEETKNALFIIEGLPGVSAEDLEAALDELAELLERYLGGEvVKTRILDADNPEFE 233
 
Name Accession Description Interval E-value
B3/B4 COG3382
B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only] ...
1-232 1.35e-91

B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only];


Pssm-ID: 442609 [Multi-domain]  Cd Length: 233  Bit Score: 268.65  E-value: 1.35e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345   1 MKFIVEKEVFDKLENVCFGVVVAKGIDNTKEIERISNLLDISIDRVEDYFKDKKVKESEEIIPYREAFRSLGMNPNKFMS 80
Cdd:COG3382    1 MKFSIDPEVFELFPGLRIGVIVAKGVDNTESPPELEALLQEAEEEARARLTLEPLKELPVIAAWREAYKKFGIDPKRYRP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345  81 SIEAMTTRVAKNKKLPHINPIVDLGNSISLKYLLPMGAHDMDFRNDDVYVRFSKKGDKFVPFGETDVELMEEGELIYSVG 160
Cdd:COG3382   81 SAEALLRRVLKGGGLPRINPLVDLYNAVSLRYLLPIGGYDLDKIEGDLRLRLARGGESFLPIGGDEEEPPEPGEVVYADD 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490589345 161 DMVKTRRWIWRQGEEGKITNSSKNIFFPIDGFTDANLDKVMSAREELAKLLKEIFNCE-IKVGFVDKDNPEME 232
Cdd:COG3382  161 EGVFCRRWPWRDSERTKVTEETKNALFIIEGLPGVSAEDLEAALDELAELLERYLGGEvVKTRILDADNPEFE 233
B3_4 pfam03483
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
64-216 4.60e-36

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 427327 [Multi-domain]  Cd Length: 174  Bit Score: 125.35  E-value: 4.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345   64 YREAFRSLGMNPNKFMSSIEAMTTRVAKNKKLPhINPIVDLGNSISLKYLLPMGAHDMDFRNDDVYVRFSKKGDKFVPFG 143
Cdd:pfam03483   2 CPRYFGRVIRGVKKNRPSPEWLQRRLRRAGIRP-INNVVDITNYVMLELGQPLHAFDLDKIAGDIVVRLAKGGEKFTTLD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345  144 ETDVELmEEGELIYSVGDMVkTRRWIWRQGEEGKITNSSKNIFFPIDGF---------------TDA--------NLDKV 200
Cdd:pfam03483  81 GKEREL-DPGDLVIADDDGP-VALAGIMGGEESEVTEDTTNIFLESAGFdpvairktarrlglrTDAsyrfergvDPELV 158
                         170
                  ....*....|....*.
gi 490589345  201 MSAREELAKLLKEIFN 216
Cdd:pfam03483 159 EAALDRATALLLELCG 174
B3_4 smart00873
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
64-215 5.18e-22

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 214876 [Multi-domain]  Cd Length: 174  Bit Score: 88.86  E-value: 5.18e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345    64 YREAFRSLGMNPNKFMSSIEAMTTRVAKNKKLPhINPIVDLGNSISLKYLLPMGAHDMD-FRNDDVYVRFSKKGDKFVPF 142
Cdd:smart00873   1 CPRYLGRVIRGVKNTRPSPEWLQERLHRAGIRP-INNVVDITNYVSLETGQPLHAFDLDkIKGKDIPLRRAKEGEKFETL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345   143 GETDVELME--------EGELIYsVGDM-----------VKTRRWIWRQGEE-GKITNSSKNIFFPIDGFTDANLD--KV 200
Cdd:smart00873  80 DGKEYELDEgdlviaddEGPLAL-AGVMggeesevtentTVIFLEPAIFSPRtIRITARTLNLFTDASGRFERGVDpeLV 158
                          170
                   ....*....|....*
gi 490589345   201 MSAREELAKLLKEIF 215
Cdd:smart00873 159 ELALDRAAALLLEIC 173
pheT PRK00629
phenylalanyl-tRNA synthetase subunit beta; Reviewed
98-230 6.58e-04

phenylalanyl-tRNA synthetase subunit beta; Reviewed


Pssm-ID: 234804 [Multi-domain]  Cd Length: 791  Bit Score: 40.54  E-value: 6.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345  98 INPIVDLGNSISLKYLLPMGAHDMDFRNDDVYVRFSKKGDKFVPFGETDVELmEEGELIYSVGD--------Mvktrrwi 169
Cdd:PRK00629 245 INNVVDITNYVMLELGQPLHAFDLDKIGGGIVVRRAKEGEKLTTLDGKERTL-DPEDLVIADDKkplalagvM------- 316
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345 170 wrQGEEGKITNSSKNIFF------PID--------GF-TDA--------NLDKVMSAREELAKLLKEIFNCEIKVGFVDK 226
Cdd:PRK00629 317 --GGEDSEVTENTTNVLLesayfdPVSirktarrlGLrTDAsyrfergvDPALTLLALERATALILELGGGEVVEGVVDV 394

                 ....
gi 490589345 227 DNPE 230
Cdd:PRK00629 395 YPLP 398
 
Name Accession Description Interval E-value
B3/B4 COG3382
B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only] ...
1-232 1.35e-91

B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only];


Pssm-ID: 442609 [Multi-domain]  Cd Length: 233  Bit Score: 268.65  E-value: 1.35e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345   1 MKFIVEKEVFDKLENVCFGVVVAKGIDNTKEIERISNLLDISIDRVEDYFKDKKVKESEEIIPYREAFRSLGMNPNKFMS 80
Cdd:COG3382    1 MKFSIDPEVFELFPGLRIGVIVAKGVDNTESPPELEALLQEAEEEARARLTLEPLKELPVIAAWREAYKKFGIDPKRYRP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345  81 SIEAMTTRVAKNKKLPHINPIVDLGNSISLKYLLPMGAHDMDFRNDDVYVRFSKKGDKFVPFGETDVELMEEGELIYSVG 160
Cdd:COG3382   81 SAEALLRRVLKGGGLPRINPLVDLYNAVSLRYLLPIGGYDLDKIEGDLRLRLARGGESFLPIGGDEEEPPEPGEVVYADD 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490589345 161 DMVKTRRWIWRQGEEGKITNSSKNIFFPIDGFTDANLDKVMSAREELAKLLKEIFNCE-IKVGFVDKDNPEME 232
Cdd:COG3382  161 EGVFCRRWPWRDSERTKVTEETKNALFIIEGLPGVSAEDLEAALDELAELLERYLGGEvVKTRILDADNPEFE 233
B3_4 pfam03483
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
64-216 4.60e-36

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 427327 [Multi-domain]  Cd Length: 174  Bit Score: 125.35  E-value: 4.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345   64 YREAFRSLGMNPNKFMSSIEAMTTRVAKNKKLPhINPIVDLGNSISLKYLLPMGAHDMDFRNDDVYVRFSKKGDKFVPFG 143
Cdd:pfam03483   2 CPRYFGRVIRGVKKNRPSPEWLQRRLRRAGIRP-INNVVDITNYVMLELGQPLHAFDLDKIAGDIVVRLAKGGEKFTTLD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345  144 ETDVELmEEGELIYSVGDMVkTRRWIWRQGEEGKITNSSKNIFFPIDGF---------------TDA--------NLDKV 200
Cdd:pfam03483  81 GKEREL-DPGDLVIADDDGP-VALAGIMGGEESEVTEDTTNIFLESAGFdpvairktarrlglrTDAsyrfergvDPELV 158
                         170
                  ....*....|....*.
gi 490589345  201 MSAREELAKLLKEIFN 216
Cdd:pfam03483 159 EAALDRATALLLELCG 174
B3_4 smart00873
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
64-215 5.18e-22

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 214876 [Multi-domain]  Cd Length: 174  Bit Score: 88.86  E-value: 5.18e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345    64 YREAFRSLGMNPNKFMSSIEAMTTRVAKNKKLPhINPIVDLGNSISLKYLLPMGAHDMD-FRNDDVYVRFSKKGDKFVPF 142
Cdd:smart00873   1 CPRYLGRVIRGVKNTRPSPEWLQERLHRAGIRP-INNVVDITNYVSLETGQPLHAFDLDkIKGKDIPLRRAKEGEKFETL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345   143 GETDVELME--------EGELIYsVGDM-----------VKTRRWIWRQGEE-GKITNSSKNIFFPIDGFTDANLD--KV 200
Cdd:smart00873  80 DGKEYELDEgdlviaddEGPLAL-AGVMggeesevtentTVIFLEPAIFSPRtIRITARTLNLFTDASGRFERGVDpeLV 158
                          170
                   ....*....|....*
gi 490589345   201 MSAREELAKLLKEIF 215
Cdd:smart00873 159 ELALDRAAALLLEIC 173
pheT PRK00629
phenylalanyl-tRNA synthetase subunit beta; Reviewed
98-230 6.58e-04

phenylalanyl-tRNA synthetase subunit beta; Reviewed


Pssm-ID: 234804 [Multi-domain]  Cd Length: 791  Bit Score: 40.54  E-value: 6.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345  98 INPIVDLGNSISLKYLLPMGAHDMDFRNDDVYVRFSKKGDKFVPFGETDVELmEEGELIYSVGD--------Mvktrrwi 169
Cdd:PRK00629 245 INNVVDITNYVMLELGQPLHAFDLDKIGGGIVVRRAKEGEKLTTLDGKERTL-DPEDLVIADDKkplalagvM------- 316
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490589345 170 wrQGEEGKITNSSKNIFF------PID--------GF-TDA--------NLDKVMSAREELAKLLKEIFNCEIKVGFVDK 226
Cdd:PRK00629 317 --GGEDSEVTENTTNVLLesayfdPVSirktarrlGLrTDAsyrfergvDPALTLLALERATALILELGGGEVVEGVVDV 394

                 ....
gi 490589345 227 DNPE 230
Cdd:PRK00629 395 YPLP 398
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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