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Conserved domains on  [gi|490656532|ref|WP_004521522|]
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MULTISPECIES: MbtH family NRPS accessory protein [Burkholderia]

Protein Classification

MbtH family protein( domain architecture ID 10007125)

MbtH family protein may be required for the synthesis of antibiotics, siderophores or glycopeptidolipids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MbtH COG3251
MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites ...
 2-65 2.37e-28

MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 442482  Cd Length: 71  Bit Score: 96.48  E-value: 2.37e-28
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490656532  2 DDELYFVVRNNEGQYSVWMDGRSLPAGWETVGEPATKQQCLQRIEQLWTDMVPASVREHLNQHS 65
Cdd:COG3251   8 DDGTFLVLVNDEGQYSLWPAFRAVPAGWRVVGGPGSREECLAYIEEHWTDMRPLSLREAMAEQA 71
 
Name Accession Description Interval E-value
MbtH COG3251
MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites ...
 2-65 2.37e-28

MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442482  Cd Length: 71  Bit Score: 96.48  E-value: 2.37e-28
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490656532  2 DDELYFVVRNNEGQYSVWMDGRSLPAGWETVGEPATKQQCLQRIEQLWTDMVPASVREHLNQHS 65
Cdd:COG3251   8 DDGTFLVLVNDEGQYSLWPAFRAVPAGWRVVGGPGSREECLAYIEEHWTDMRPLSLREAMAEQA 71
MbtH smart00923
MbtH-like protein; This domain is found in the MbtH protein as well as at the N-terminus of ...
 2-47 4.05e-19

MbtH-like protein; This domain is found in the MbtH protein as well as at the N-terminus of the antibiotic synthesis protein NIKP1. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. Many of the members of this family are found in known antibiotic synthesis gene clusters.


Pssm-ID: 197991  Cd Length: 49  Bit Score: 72.22  E-value: 4.05e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 490656532    2 DDELYFVVRNNEGQYSVWMDGRSLPAGWETVGEPATKQQCLQRIEQ 47
Cdd:smart00923  4 EDGTFLVLVNDEGQYSLWPAFLPVPAGWRVVGGPGSRAACLDYIEE 49
MbtH pfam03621
MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of ...
 2-47 1.16e-16

MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.


Pssm-ID: 427405  Cd Length: 53  Bit Score: 66.38  E-value: 1.16e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 490656532   2 DDELYFVVRNNEGQYSVWMDGRSLPAGWETVGEPATKQQCLQRIEQ 47
Cdd:pfam03621  8 DDGTFLVLVNDEGQYSLWPAFAPVPAGWRVVGGPGSRQECLDYIEE 53
 
Name Accession Description Interval E-value
MbtH COG3251
MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites ...
 2-65 2.37e-28

MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442482  Cd Length: 71  Bit Score: 96.48  E-value: 2.37e-28
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490656532  2 DDELYFVVRNNEGQYSVWMDGRSLPAGWETVGEPATKQQCLQRIEQLWTDMVPASVREHLNQHS 65
Cdd:COG3251   8 DDGTFLVLVNDEGQYSLWPAFRAVPAGWRVVGGPGSREECLAYIEEHWTDMRPLSLREAMAEQA 71
MbtH smart00923
MbtH-like protein; This domain is found in the MbtH protein as well as at the N-terminus of ...
 2-47 4.05e-19

MbtH-like protein; This domain is found in the MbtH protein as well as at the N-terminus of the antibiotic synthesis protein NIKP1. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. Many of the members of this family are found in known antibiotic synthesis gene clusters.


Pssm-ID: 197991  Cd Length: 49  Bit Score: 72.22  E-value: 4.05e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 490656532    2 DDELYFVVRNNEGQYSVWMDGRSLPAGWETVGEPATKQQCLQRIEQ 47
Cdd:smart00923  4 EDGTFLVLVNDEGQYSLWPAFLPVPAGWRVVGGPGSRAACLDYIEE 49
MbtH pfam03621
MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of ...
 2-47 1.16e-16

MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.


Pssm-ID: 427405  Cd Length: 53  Bit Score: 66.38  E-value: 1.16e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 490656532   2 DDELYFVVRNNEGQYSVWMDGRSLPAGWETVGEPATKQQCLQRIEQ 47
Cdd:pfam03621  8 DDGTFLVLVNDEGQYSLWPAFAPVPAGWRVVGGPGSRQECLDYIEE 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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