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Conserved domains on  [gi|490713966|ref|WP_004576734|]
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MULTISPECIES: transcriptional regulator ArgR [Pseudomonas]

Protein Classification

GlxA family transcriptional regulator( domain architecture ID 11471967)

GlxA family transcriptional regulator contains an amidase domain and an AraC-type DNA-binding helix-turn-helix (HTH) domain

Gene Ontology:  GO:0003677|GO:0003700|GO:0006355
PubMed:  15808743|33837749|15070401|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 4-315 4.41e-100

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


:

Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 297.07  E-value: 4.41e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966   4 QRIGFLIWPSTRPLTLALAEEVLLVAQRVHPDVVYELVFLQAEPAQ---EGAWRLPGEPWTGRLEGCHKLFLLA-DEPPA 79
Cdd:COG4977    1 LRVAFLLLPGFSLLDLAGPLEVFRLANRLAGRPLYRWRLVSLDGGPvrsSSGLTVAPDHGLADLAAADTLIVPGgLDPAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966  80 AMGAAFSAALKQLARSGCLIGGLSAGVYPLAMLGLLDGYRAAVHWRWQDDFAERFPKVIATSHLFDW-DRDRLTACGGMA 158
Cdd:COG4977   81 AADPALLAWLRRAAARGARLASICTGAFLLAAAGLLDGRRATTHWEHADAFAERFPDVRVDPDRLYVdDGDILTSAGGTA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 159 VTDLLLAVLARDHGAELAGAVSEELVVERIREGGERQRIPLQNRLGSSHPKLTQAVLLMEANIEEPLTTDEIAQHVCVSR 238
Cdd:COG4977  161 GIDLALHLVERDHGAELANAVARRLVVDPRRPGGQAQFSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSP 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490713966 239 RQLERIFKQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNFFGATPREDRNQRRSSSP 315
Cdd:COG4977  241 RTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARAA 317
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 4-315 4.41e-100

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 297.07  E-value: 4.41e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966   4 QRIGFLIWPSTRPLTLALAEEVLLVAQRVHPDVVYELVFLQAEPAQ---EGAWRLPGEPWTGRLEGCHKLFLLA-DEPPA 79
Cdd:COG4977    1 LRVAFLLLPGFSLLDLAGPLEVFRLANRLAGRPLYRWRLVSLDGGPvrsSSGLTVAPDHGLADLAAADTLIVPGgLDPAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966  80 AMGAAFSAALKQLARSGCLIGGLSAGVYPLAMLGLLDGYRAAVHWRWQDDFAERFPKVIATSHLFDW-DRDRLTACGGMA 158
Cdd:COG4977   81 AADPALLAWLRRAAARGARLASICTGAFLLAAAGLLDGRRATTHWEHADAFAERFPDVRVDPDRLYVdDGDILTSAGGTA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 159 VTDLLLAVLARDHGAELAGAVSEELVVERIREGGERQRIPLQNRLGSSHPKLTQAVLLMEANIEEPLTTDEIAQHVCVSR 238
Cdd:COG4977  161 GIDLALHLVERDHGAELANAVARRLVVDPRRPGGQAQFSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSP 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490713966 239 RQLERIFKQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNFFGATPREDRNQRRSSSP 315
Cdd:COG4977  241 RTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARAA 317
GATase1_AraC_ArgR_like cd03136
AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase ...
 6-186 1.60e-49

AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; A subgroup of AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain. This group contains proteins similar to the Pseudomonas aeruginosa ArgR regulator. ArgR functions in the control of expression of certain genes of arginine biosynthesis and catabolism. AraC regulators are defined by a AraC-type helix-turn-helix DNA binding domain at their C-terminal. AraC family transcriptional regulators are widespread among bacteria and are involved in regulating diverse and important biological functions, including carbon metabolism, stress responses and virulence in different microorganisms. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with typical GATase1domains a reactive cys residue is found in some sequences in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.


Pssm-ID: 153230 [Multi-domain]  Cd Length: 185  Bit Score: 163.14  E-value: 1.60e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966   6 IGFLIWPSTRPLTLALAEEVLLVAQRVHPDVVYELVFLQAEPAQEGA---WRLPGEPWTGRLEGCHKLFLLA-DEPPAAM 81
Cdd:cd03136    1 FGFLLLPGFSLLALASAIEPLRAANRLAGRELYRWRVLSLDGAPVTSsngLRVAPDAALEDAPPLDYLFVVGgLGARRAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966  82 GAAFSAALKQLARSGCLIGGLSAGVYPLAMLGLLDGYRAAVHWRWQDDFAERFPKVIATSHLFDWDRDRLTACGGMAVTD 161
Cdd:cd03136   81 TPALLAWLRRAARRGVALGGIDTGAFLLARAGLLDGRRATVHWEHLEAFAEAFPRVQVTRDLFEIDGDRLTCAGGTAALD 160

                        170       180
                 ....*....|....*....|....*
gi 490713966 162 LLLAVLARDHGAELAGAVSEELVVE 186
Cdd:cd03136  161 LMLELIARDHGAALAARVAEQFLHD 185
ftrA PRK09393
transcriptional activator FtrA; Provisional
 89-303 7.87e-32

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 121.22  E-value: 7.87e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966  89 LKQLARSGCLIGGLSAGVYPLAMLGLLDGYRAAVHWRWQDDFAERFPKV-IATSHLFDWDRDRLTACGGMAVTDLLLAVL 167
Cdd:PRK09393  99 LRAAHARGARLCSICSGVFVLAAAGLLDGRRATTHWRYAERLQARYPAIrVDPDVLYVDEGQILTSAGSAAGIDLCLHLV 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 168 ARDHGAELAGAVSEELVVERIREGGERQRI--PLQNRLGSSHPKLTQAvllMEANIEEPLTTDEIAQHVCVSRRQLERIF 245
Cdd:PRK09393 179 RRDFGSEAANRVARRLVVPPHRDGGQAQFVprPVASRESDRLGPLIDW---MRAHLAEPHTVASLAARAAMSPRTFLRRF 255

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490713966 246 KQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNFFGATP 303
Cdd:PRK09393 256 EAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLRHHFRRRAATSP 313
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
224-307 7.45e-29

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 106.10  E-value: 7.45e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966   224 PLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNFFGATP 303
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 490713966   304 REDR 307
Cdd:smart00342  81 SEYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
230-309 4.25e-23

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 91.11  E-value: 4.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966  230 IAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLMQ-TSKSIIQIGLSCGFSSGPHFSSAYRNFFGATPREDRN 308
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 490713966  309 Q 309
Cdd:pfam12833  81 R 81
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 4-315 4.41e-100

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 297.07  E-value: 4.41e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966   4 QRIGFLIWPSTRPLTLALAEEVLLVAQRVHPDVVYELVFLQAEPAQ---EGAWRLPGEPWTGRLEGCHKLFLLA-DEPPA 79
Cdd:COG4977    1 LRVAFLLLPGFSLLDLAGPLEVFRLANRLAGRPLYRWRLVSLDGGPvrsSSGLTVAPDHGLADLAAADTLIVPGgLDPAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966  80 AMGAAFSAALKQLARSGCLIGGLSAGVYPLAMLGLLDGYRAAVHWRWQDDFAERFPKVIATSHLFDW-DRDRLTACGGMA 158
Cdd:COG4977   81 AADPALLAWLRRAAARGARLASICTGAFLLAAAGLLDGRRATTHWEHADAFAERFPDVRVDPDRLYVdDGDILTSAGGTA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 159 VTDLLLAVLARDHGAELAGAVSEELVVERIREGGERQRIPLQNRLGSSHPKLTQAVLLMEANIEEPLTTDEIAQHVCVSR 238
Cdd:COG4977  161 GIDLALHLVERDHGAELANAVARRLVVDPRRPGGQAQFSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSP 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490713966 239 RQLERIFKQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNFFGATPREDRNQRRSSSP 315
Cdd:COG4977  241 RTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARAA 317
GATase1_AraC_ArgR_like cd03136
AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase ...
 6-186 1.60e-49

AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; A subgroup of AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain. This group contains proteins similar to the Pseudomonas aeruginosa ArgR regulator. ArgR functions in the control of expression of certain genes of arginine biosynthesis and catabolism. AraC regulators are defined by a AraC-type helix-turn-helix DNA binding domain at their C-terminal. AraC family transcriptional regulators are widespread among bacteria and are involved in regulating diverse and important biological functions, including carbon metabolism, stress responses and virulence in different microorganisms. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with typical GATase1domains a reactive cys residue is found in some sequences in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.


Pssm-ID: 153230 [Multi-domain]  Cd Length: 185  Bit Score: 163.14  E-value: 1.60e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966   6 IGFLIWPSTRPLTLALAEEVLLVAQRVHPDVVYELVFLQAEPAQEGA---WRLPGEPWTGRLEGCHKLFLLA-DEPPAAM 81
Cdd:cd03136    1 FGFLLLPGFSLLALASAIEPLRAANRLAGRELYRWRVLSLDGAPVTSsngLRVAPDAALEDAPPLDYLFVVGgLGARRAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966  82 GAAFSAALKQLARSGCLIGGLSAGVYPLAMLGLLDGYRAAVHWRWQDDFAERFPKVIATSHLFDWDRDRLTACGGMAVTD 161
Cdd:cd03136   81 TPALLAWLRRAARRGVALGGIDTGAFLLARAGLLDGRRATVHWEHLEAFAEAFPRVQVTRDLFEIDGDRLTCAGGTAALD 160

                        170       180
                 ....*....|....*....|....*
gi 490713966 162 LLLAVLARDHGAELAGAVSEELVVE 186
Cdd:cd03136  161 LMLELIARDHGAALAARVAEQFLHD 185
ftrA PRK09393
transcriptional activator FtrA; Provisional
 89-303 7.87e-32

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 121.22  E-value: 7.87e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966  89 LKQLARSGCLIGGLSAGVYPLAMLGLLDGYRAAVHWRWQDDFAERFPKV-IATSHLFDWDRDRLTACGGMAVTDLLLAVL 167
Cdd:PRK09393  99 LRAAHARGARLCSICSGVFVLAAAGLLDGRRATTHWRYAERLQARYPAIrVDPDVLYVDEGQILTSAGSAAGIDLCLHLV 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 168 ARDHGAELAGAVSEELVVERIREGGERQRI--PLQNRLGSSHPKLTQAvllMEANIEEPLTTDEIAQHVCVSRRQLERIF 245
Cdd:PRK09393 179 RRDFGSEAANRVARRLVVPPHRDGGQAQFVprPVASRESDRLGPLIDW---MRAHLAEPHTVASLAARAAMSPRTFLRRF 255

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490713966 246 KQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNFFGATP 303
Cdd:PRK09393 256 EAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLRHHFRRRAATSP 313
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
224-307 7.45e-29

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 106.10  E-value: 7.45e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966   224 PLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNFFGATP 303
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 490713966   304 REDR 307
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
106-314 5.82e-25

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 101.40  E-value: 5.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 106 VYPLAMLGLLDGYRAAVHWRWQDDFAERFPKVIATSHLFDWDRDRLTACGGMAVTDLLLAVLARDHGAELAGAVSEELVV 185
Cdd:COG2207   50 LLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 186 ERIREGGERQRIPLQNRLGSSHPKLTQAVLLMEANIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKA 265
Cdd:COG2207  130 LLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERA 209

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 490713966 266 RQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNFFGATPREDRNQRRSSS 314
Cdd:COG2207  210 KRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRARA 258
HTH_18 pfam12833
Helix-turn-helix domain;
230-309 4.25e-23

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 91.11  E-value: 4.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966  230 IAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLMQ-TSKSIIQIGLSCGFSSGPHFSSAYRNFFGATPREDRN 308
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 490713966  309 Q 309
Cdd:pfam12833  81 R 81
GATase1_AraC_1 cd03137
AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like ...
 6-185 1.38e-21

AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; A subgroup of AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain. AraC regulators are defined by a AraC-type helix-turn-helix DNA binding domain at their C-terminal. AraC family transcriptional regulators are widespread among bacteria and are involved in regulating diverse and important biological functions, including carbon metabolism, stress responses and virulence in different microorganisms. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with typical GATase1domains a reactive cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.


Pssm-ID: 153231 [Multi-domain]  Cd Length: 187  Bit Score: 90.25  E-value: 1.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966   6 IGFLIWPSTRPLTLALAEEVLLVAQRVHPDVVYELVFLQAEPAQEGA---WRLPGEPWTGRLEGCHKLFLLADEPPAAMG 82
Cdd:cd03137    1 VAVLVFPGVSLLDLSGPAEVFGEANRALGPPAYELRVCSPEGGPVRSssgLSLVADAGLDALAAADTVIVPGGPDVDGRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966  83 AAFSAA--LKQLARSGCLIGGLSAGVYPLAMLGLLDGYRAAVHWRWQDDFAERFPKV-IATSHLFDWDRDRLTACGGMAV 159
Cdd:cd03137   81 PPPALLaaLRRAAARGARVASVCTGAFVLAEAGLLDGRRATTHWAYAEDLARRFPAVrVDPDVLYVDDGNVWTSAGVTAG 160

                        170       180
                 ....*....|....*....|....*.
gi 490713966 160 TDLLLAVLARDHGAELAGAVSEELVV 185
Cdd:cd03137  161 IDLCLHLVREDLGAAVANRVARRLVV 186
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 198-311 5.34e-17

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 80.48  E-value: 5.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 198 PLQNRLGSSHPKL-TQAVLLMEANIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLmQTSKSI 276
Cdd:COG2169   73 PDLAPGSPPRADLvARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLL-QTGLSV 151

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 490713966 277 IQIGLSCGFSSGPHFSSAYRNFFGATPREDRNQRR 311
Cdd:COG2169  152 TDAAYAAGFGSLSRFYEAFKKLLGMTPSAYRRGGA 186
GATase1_AraC_2 cd03138
AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like ...
 6-186 2.14e-16

AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; A subgroup of AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain. AraC regulators are defined by a AraC-type helix-turn-helix DNA binding domain at their C-terminal. AraC family transcriptional regulators are widespread among bacteria and are involved in regulating diverse and important biological functions, including carbon metabolism, stress responses and virulence in different microorganisms. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with typical GATase1domains a reactive cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.


Pssm-ID: 153232 [Multi-domain]  Cd Length: 195  Bit Score: 76.15  E-value: 2.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966   6 IGFLIWPSTRPLTLALAEEVLLVAQRVHPDVVYE-------LVFLQAEPAQEGAwRLPGEPWT--GRLEGC-----HKLF 71
Cdd:cd03138    1 VTLLAYPGALASSLAGLLDLLRAANRLARRQQGGappfevrLVSLDGGPVLLAG-GILILPDAtlADVPAPdlvivPGLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966  72 LLADEPPAAMGAAFSAALKQLARSGCLIGGLSAGVYPLAMLGLLDGYRAAVHWRWQDDFAERFPKViatshlfDWDRDRL 151
Cdd:cd03138   80 GDPDELLLADNPALIAWLRRQHANGATVAAACTGVFLLAEAGLLDGRRATTHWWLAPQFRRRFPKV-------RLDPDRV 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 490713966 152 --------TACGGMAVTDLLLAVLARDHGAELAGAVSEELVVE 186
Cdd:cd03138  153 vvtdgnliTAGGAMAWADLALHLIERLAGPELAQLVARFLLID 195
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
209-313 2.20e-15

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 75.10  E-value: 2.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 209 KLTQAVLLMEANIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSG 288
Cdd:PRK13503 172 RLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDS 251

                         90       100
                 ....*....|....*....|....*
gi 490713966 289 PHFSSAYRNFFGATPREDRNQRRSS 313
Cdd:PRK13503 252 NHFSTLFRREFSWSPRDIRQGRDGF 276
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
174-311 6.96e-11

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 61.91  E-value: 6.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 174 ELAGAVSEELVVERIREggerqrIPLqnrlgSSHPKLTQAVL----LMEANIEEPLTTDEIAQHVCVSRRQLERIFKQYL 249
Cdd:PRK10572 156 LLAMNLLERLLLRCMEA------IPE-----SLHPPMDPRVReacqYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQL 224

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490713966 250 NRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNFFGATPREDRNQRR 311
Cdd:PRK10572 225 GISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRARCE 286
PRK10371 PRK10371
transcriptional regulator MelR;
219-315 2.93e-10

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 60.22  E-value: 2.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 219 ANIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNF 298
Cdd:PRK10371 202 ENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYSTFGKY 281

                         90       100
                 ....*....|....*....|
gi 490713966 299 FGATPREDR---NQRRSSSP 315
Cdd:PRK10371 282 VGMSPQQYRklsQQRRQTFP 301
GATase1_PfpI_2 cd03139
Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins ...
 109-183 1.18e-09

Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.


Pssm-ID: 153233 [Multi-domain]  Cd Length: 183  Bit Score: 56.78  E-value: 1.18e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490713966 109 LAMLGLLDGYRAAVHWRWQDDFAERFPKVIATSHLFDwDRDRLTACGGMAVTDLLLAVLARDHGAELAGAVSEEL 183
Cdd:cd03139  107 LAAAGLLDGRRATTHWAAIDWLKEFGAIVVVDARWVV-DGNIWTSGGVSAGIDMALALVARLFGEELAQAVALLI 180
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 199-311 1.88e-08

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 54.65  E-value: 1.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 199 LQNR---LGSSHPKLTQAVLLMEANIEEP-LTTDEIAQHVCVSRRQLERIFKQYlNRVPSQYYLELRLNKARQMLMQTSK 274
Cdd:PRK09685 185 LHQResvQPRRERQFQKVVALIDQSIQEEiLRPEWIAGELGISVRSLYRLFAEQ-GLVVAQYIRNRRLDRCADDLRPAAD 263

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 490713966 275 --SIIQIGLSCGFSSGPHFSSAYRNFFGATPREDRNQRR 311
Cdd:PRK09685 264 deKITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYRRKFR 302
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 217-256 3.97e-08

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 48.69  E-value: 3.97e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 490713966  217 MEANIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQY 256
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQY 40
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
217-307 2.02e-07

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 49.33  E-value: 2.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 217 MEANIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYR 296
Cdd:PRK11511  18 IEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTFK 97

                         90
                 ....*....|.
gi 490713966 297 NFFGATPREDR 307
Cdd:PRK11511  98 NYFDVPPHKYR 108
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
193-308 5.12e-07

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 50.44  E-value: 5.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 193 ERQRIPLQNRLGSSHPKLTQAVLLMEAN-IEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLMQ 271
Cdd:PRK13502 160 KRHRYATDDLPATSRETLLDKLITALANsLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQH 239

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 490713966 272 TSKSIIQIGLSCGFSSGPHFSSAYRNFFGATPREDRN 308
Cdd:PRK13502 240 SPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWRH 276
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 193-321 9.12e-07

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 49.54  E-value: 9.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 193 ERQRIPLQNRLgsSHPKLTQAVL-LMEANIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVpSQYYLELRLNKARQMLMQ 271
Cdd:PRK09978 128 DEHFIPLLLNV--LQPNMRTRVCtVINNNIAHEWTLARIASELLMSPSLLKKKLREEETSY-SQLLTECRMQRALQLIVI 204

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 490713966 272 TSKSIIQIGLSCGFSSGPHFSSAYRNFFGATPREDRNQRRSSSPFELSSA 321
Cdd:PRK09978 205 HGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQERSAQGLPNRDSAA 254
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 219-305 1.32e-06

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 49.29  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 219 ANIEEPLTTDEIAQHVCVSRRQLERIFKQYlNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNF 298
Cdd:PRK15186 192 SDISRKWALKDISDSLYMSCSTLKRKLKQE-NTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKH 270


                 ....*..
gi 490713966 299 FGATPRE 305
Cdd:PRK15186 271 FKTTPSE 277
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
205-308 4.69e-06

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 47.40  E-value: 4.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 205 SSHPKLTQAVLLMEANIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCG 284
Cdd:PRK13500 203 SSETLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECG 282

                         90       100
                 ....*....|....*....|....
gi 490713966 285 FSSGPHFSSAYRNFFGATPREDRN 308
Cdd:PRK13500 283 FEDSNYFSVVFTRETGMTPSQWRH 306
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
208-309 4.91e-06

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 47.21  E-value: 4.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 208 PKLTQAVLLMEA---NIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCG 284
Cdd:PRK13501 173 PDGEQLDLIMSAlqqSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCG 252

                         90       100
                 ....*....|....*....|....*
gi 490713966 285 FSSGPHFSSAYRNFFGATPREDRNQ 309
Cdd:PRK13501 253 FEDSNYFSAVFTREAGMTPRDYRQR 277
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
217-303 9.97e-05

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 43.46  E-value: 9.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 217 MEANIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYR 296
Cdd:PRK15121  14 LEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQYRFDSQQTFTRAFK 93


                 ....*..
gi 490713966 297 NFFGATP 303
Cdd:PRK15121  94 KQFAQTP 100
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
198-308 1.42e-04

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 43.24  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 198 PLQNRLGsshpKLTQAVLLMEAniEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLMQtSKSII 277
Cdd:PRK15435  79 PQQHRLD----KITHACRLLEQ--ETPVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREALAK-GESVT 151

                         90       100       110
                 ....*....|....*....|....*....|....
gi 490713966 278 QIGLSCGFSSGphfSSAYRN---FFGATPREDRN 308
Cdd:PRK15435 152 TSILNAGFPDS---SSYYRKadeTLGMTAKQFRH 182
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 270-308 4.59e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 37.13  E-value: 4.59e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 490713966  270 MQTSKSIIQIGLSCGFSSGpHFSSAYRNFFGATPREDRN 308
Cdd:pfam00165   5 LSTNLTIADIADELGFSRS-YFSRLFKKYTGVTPSQYRH 42
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 216-314 7.48e-04

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 40.45  E-value: 7.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 216 LMEANIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVpSQYYLELRLNKARQmLMQTSKSIIQIGLSCGFSSGPHFSSAY 295
Cdd:PRK09940 142 IVNMKLAHPWKLKDICDCLYISESLLKKKLKQEQTTF-SQILLDARMQHAKN-LIRVEGSVNKIAEQCGYASTSYFIYAF 219

                         90
                 ....*....|....*....
gi 490713966 296 RNFFGATPREDRNQRRSSS 314
Cdd:PRK09940 220 RKHFGNSPKRVSKEYRCQR 238
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 228-303 1.11e-03

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 40.36  E-value: 1.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490713966 228 DEIAQHVCVSRRQLERIFKQYLNRVpSQYYLELRLNKARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNFFGATP 303
Cdd:PRK15185 226 TDVADHIFMSTSTLKRKLAEEGTSF-SDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTP 300
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
220-310 3.53e-03

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 38.75  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490713966 220 NIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNKARQMLM---QTSKSIIQIGLSCGFSSGPHFSSAYR 296
Cdd:PRK10130 252 NMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELIspwSQSTTVKDAAMQWGFWHLGQFATDYQ 331

                         90
                 ....*....|....
gi 490713966 297 NFFGATPREDRNQR 310
Cdd:PRK10130 332 QLFAEKPSLTLHQR 345
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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