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Conserved domains on  [gi|490723786|ref|WP_004586338|]
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MULTISPECIES: TonB-dependent receptor plug domain-containing protein [Pseudoalteromonas]

Protein Classification

TonB-dependent receptor( domain architecture ID 1003665)

TonB-dependent receptor may act as a channel to allow import of extracellular nutrients, such as iron-siderophore complexes or non-Fe compounds

Gene Ontology:  GO:0015891

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
TonB-Xanth-Caul super family cl36973
TonB-dependent receptor; This model represents a family of TonB-dependent outer-membrane ...
40-880 1.18e-50

TonB-dependent receptor; This model represents a family of TonB-dependent outer-membrane receptors which are found mainly in Xanthomonas and Caulobacter. These appear to represent the expansion of a paralogous family in that the 22 X. axonopodis (21 in X. campestris) and 18 C. crescentus sequences are more closely related to each other than any of the many TonB-dependent receptors found in other species. In fact, the Crescentus and Xanthomonas sequences are inseparable on a phylogenetic tree using a PAM-weighted neighbor-joining method, indicating that one of the two genuses may have acquired this set of receptors from the other. The mechanism by which this family is shared between Xanthomonas, a gamma proteobacterial plant pathogen and Caulobacter, an alpha proteobacterial aquatic organism is unclear. [Transport and binding proteins, Porins]


The actual alignment was detected with superfamily member TIGR01782:

Pssm-ID: 273804 [Multi-domain]  Cd Length: 845  Bit Score: 192.16  E-value: 1.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786   40 IEEVVAVGTRlqGSAAAVVEERKNQAFVADILGSEQLSRTGDSDAASALRRVTGLTLV----DGKFIYVRGLGERYSSAR 115
Cdd:TIGR01782   1 LDAVQVTGQR--ASLEKAIDAKRDADSVVDVISAEDIGKLPDVNVAEALQRVPGVSIErdqgEGRYVSVRGLGPSYNRTT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  116 LNGAYIPSPDLTRNVIPLDIFPASIIESMAVQKAYSPDMPAAFGGGNIDIRTKTA----PSEFTAGIEVGAgYDTASSDG 191
Cdd:TIGR01782  79 LNGRTIASTDSGGRAFSLDLLPSELVSGVEVYKTPTADMDEGGIGGTVDLRTRSPfdydGRTLSGSAQGGY-NDLAGKDK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  192 ftynrnengipselsqaiSTYRGDFSIGNIvssegFEDGDLtraeqatavnnallkslprdyelkeesldprynikahyg 271
Cdd:TIGR01782 158 ------------------PGPRGAASYSWT-----FGDGQF--------------------------------------- 175
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  272 dsfeesyfggkvGFLLAGAYknewdfeerfssvitQDLENEEGNV------DCTTSLATSEDVSNScyNTVKNSQVTTET 345
Cdd:TIGR01782 176 ------------GVLLSASY---------------QKRDFAEDNVetenwgTYTSADGGAQGLYFP--RGVRYRSYRNDR 226
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  346 ESYNGSLSLSYRLG-THSISAQQLYIIDNEDESEIAISQSPAGSSTFSIAGDGIANRN-------------HEFNYEERQ 411
Cdd:TIGR01782 227 ERKGVNGSLQWRPSdALELYLDTLYSKYDDDETRQQIEFRTLNGGSTVITSNQTATSGalvqgtvanlqilVEARYNEEK 306
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  412 LNITQVM--GQHTFlDYFGIGADWQYTEAKATTDIPTSA---------DFEFR---------DTYNSDGSYAGSTITGDD 471
Cdd:TIGR01782 307 ETTTSLTlgGEWTG-DRWTLDGDLGYSKATRDRPDRVTRfftaptpgyDFDYRggptltlgtPADGDDASNYTNPANGEL 385
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  472 NRVIMSYTNMEERVKSyggnLTLPLSFESMEVEFKVGYDFSDRARIFNTSSFAINNSGGSGIS---------INDGSTDA 542
Cdd:TIGR01782 386 RRTQISYQKAEDSEDA----AQLDATFDGPFTSLKFGVRYRRRDKTNRGSRYRRSIIGATGASglagvpsdlAGAGLDGG 461
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  543 LNNSGFL---TDDFIDNNAVLVDFNEPTAPDADDYIAA-----QKVDAGYASFDVFYDQWIRISGGIRYEEFKQSSIGTS 614
Cdd:TIGR01782 462 LGGPLTGwdpADLDAFLNAARGDAAGGGTYTYASTAPNtytvtEDTTAAYAMANFDTGLRLRGNVGVRYERTDQTSDGWQ 541
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  615 SlifdeddlntfyDPDKIQAGSVIT--------DDWYPALSVTYVGGDDYQVRLGYGETVVRPDFREVVP-VTYYDPLTD 685
Cdd:TIGR01782 542 S------------QPAANGTGSVLVpvsadrdyTDVLPSLNLAYDLTDDLVLRFAASKTITRPDFGDLAAnTSLSDDGTG 609
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  686 IRTFGRTG---IKSSPIKNYDLRYEYYGQAGNSFSVAAFYKDI---------TAPIETVLNIGDEDYSAS-FINGETA-E 751
Cdd:TIGR01782 610 GTVTVSGGnpdLKPYESDNLDLSLEWYFGPGGLLSAAVFYKDIknfivtttsTETNDGGGGLVVAGVLVSrPVNGGKAgK 689
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  752 VYGIEAEWLQDLTFVS---EGLFTSGNITLSDSEASIDpalAGTLTNPKKRMTGHSEYVVNLQLNYDSldGMHSSSLVYN 828
Cdd:TIGR01782 690 IRGVELGYQQTFDFLPgplSGFGVQANYTYVDSEADPS---VDGVQRRKLPLPGLSKNTANATLYYEK--GGFSARLSYN 764
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 490723786  829 VFGERILAAGVAN--RDDAYEQPFHSLDLVYTYypDFNSKIK--FKVKNLLDEDQE 880
Cdd:TIGR01782 765 YRSDYLLDVGGSNinRLDRYVDPRGQLDLSASY--QVSDHLSlgLQASNLTNEPSR 818
 
Name Accession Description Interval E-value
TonB-Xanth-Caul TIGR01782
TonB-dependent receptor; This model represents a family of TonB-dependent outer-membrane ...
40-880 1.18e-50

TonB-dependent receptor; This model represents a family of TonB-dependent outer-membrane receptors which are found mainly in Xanthomonas and Caulobacter. These appear to represent the expansion of a paralogous family in that the 22 X. axonopodis (21 in X. campestris) and 18 C. crescentus sequences are more closely related to each other than any of the many TonB-dependent receptors found in other species. In fact, the Crescentus and Xanthomonas sequences are inseparable on a phylogenetic tree using a PAM-weighted neighbor-joining method, indicating that one of the two genuses may have acquired this set of receptors from the other. The mechanism by which this family is shared between Xanthomonas, a gamma proteobacterial plant pathogen and Caulobacter, an alpha proteobacterial aquatic organism is unclear. [Transport and binding proteins, Porins]


Pssm-ID: 273804 [Multi-domain]  Cd Length: 845  Bit Score: 192.16  E-value: 1.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786   40 IEEVVAVGTRlqGSAAAVVEERKNQAFVADILGSEQLSRTGDSDAASALRRVTGLTLV----DGKFIYVRGLGERYSSAR 115
Cdd:TIGR01782   1 LDAVQVTGQR--ASLEKAIDAKRDADSVVDVISAEDIGKLPDVNVAEALQRVPGVSIErdqgEGRYVSVRGLGPSYNRTT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  116 LNGAYIPSPDLTRNVIPLDIFPASIIESMAVQKAYSPDMPAAFGGGNIDIRTKTA----PSEFTAGIEVGAgYDTASSDG 191
Cdd:TIGR01782  79 LNGRTIASTDSGGRAFSLDLLPSELVSGVEVYKTPTADMDEGGIGGTVDLRTRSPfdydGRTLSGSAQGGY-NDLAGKDK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  192 ftynrnengipselsqaiSTYRGDFSIGNIvssegFEDGDLtraeqatavnnallkslprdyelkeesldprynikahyg 271
Cdd:TIGR01782 158 ------------------PGPRGAASYSWT-----FGDGQF--------------------------------------- 175
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  272 dsfeesyfggkvGFLLAGAYknewdfeerfssvitQDLENEEGNV------DCTTSLATSEDVSNScyNTVKNSQVTTET 345
Cdd:TIGR01782 176 ------------GVLLSASY---------------QKRDFAEDNVetenwgTYTSADGGAQGLYFP--RGVRYRSYRNDR 226
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  346 ESYNGSLSLSYRLG-THSISAQQLYIIDNEDESEIAISQSPAGSSTFSIAGDGIANRN-------------HEFNYEERQ 411
Cdd:TIGR01782 227 ERKGVNGSLQWRPSdALELYLDTLYSKYDDDETRQQIEFRTLNGGSTVITSNQTATSGalvqgtvanlqilVEARYNEEK 306
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  412 LNITQVM--GQHTFlDYFGIGADWQYTEAKATTDIPTSA---------DFEFR---------DTYNSDGSYAGSTITGDD 471
Cdd:TIGR01782 307 ETTTSLTlgGEWTG-DRWTLDGDLGYSKATRDRPDRVTRfftaptpgyDFDYRggptltlgtPADGDDASNYTNPANGEL 385
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  472 NRVIMSYTNMEERVKSyggnLTLPLSFESMEVEFKVGYDFSDRARIFNTSSFAINNSGGSGIS---------INDGSTDA 542
Cdd:TIGR01782 386 RRTQISYQKAEDSEDA----AQLDATFDGPFTSLKFGVRYRRRDKTNRGSRYRRSIIGATGASglagvpsdlAGAGLDGG 461
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  543 LNNSGFL---TDDFIDNNAVLVDFNEPTAPDADDYIAA-----QKVDAGYASFDVFYDQWIRISGGIRYEEFKQSSIGTS 614
Cdd:TIGR01782 462 LGGPLTGwdpADLDAFLNAARGDAAGGGTYTYASTAPNtytvtEDTTAAYAMANFDTGLRLRGNVGVRYERTDQTSDGWQ 541
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  615 SlifdeddlntfyDPDKIQAGSVIT--------DDWYPALSVTYVGGDDYQVRLGYGETVVRPDFREVVP-VTYYDPLTD 685
Cdd:TIGR01782 542 S------------QPAANGTGSVLVpvsadrdyTDVLPSLNLAYDLTDDLVLRFAASKTITRPDFGDLAAnTSLSDDGTG 609
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  686 IRTFGRTG---IKSSPIKNYDLRYEYYGQAGNSFSVAAFYKDI---------TAPIETVLNIGDEDYSAS-FINGETA-E 751
Cdd:TIGR01782 610 GTVTVSGGnpdLKPYESDNLDLSLEWYFGPGGLLSAAVFYKDIknfivtttsTETNDGGGGLVVAGVLVSrPVNGGKAgK 689
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  752 VYGIEAEWLQDLTFVS---EGLFTSGNITLSDSEASIDpalAGTLTNPKKRMTGHSEYVVNLQLNYDSldGMHSSSLVYN 828
Cdd:TIGR01782 690 IRGVELGYQQTFDFLPgplSGFGVQANYTYVDSEADPS---VDGVQRRKLPLPGLSKNTANATLYYEK--GGFSARLSYN 764
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 490723786  829 VFGERILAAGVAN--RDDAYEQPFHSLDLVYTYypDFNSKIK--FKVKNLLDEDQE 880
Cdd:TIGR01782 765 YRSDYLLDVGGSNinRLDRYVDPRGQLDLSASY--QVSDHLSlgLQASNLTNEPSR 818
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
69-905 2.06e-25

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 112.54  E-value: 2.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  69 DILGSEQLSRTGDSDAASALRRVTGLTLVDG-----KFIYVRGLGERYSSARLNGAYIPSPDLTRNViPLDIFPASIIES 143
Cdd:cd01347    3 SVITAEDIEKQPATSLADLLRRIPGVSVTRGgggggSTISIRGFGPDRTLVLVDGLPLASSNYGRGV-DLNTIPPELIER 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 144 MAVQKAYSPDMPAAFG-GGNIDIRTKTAPSEFtaGIEVGAGYDTASSDgftynrnengipselsqaiSTYRGDFSIGNIV 222
Cdd:cd01347   82 VEVLKGPSSALYGSGAiGGVVNIITKRPTDEF--GGSVTAGYGSDNSG-------------------SSGGGGFDVSGAL 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 223 SsegfedgdltraeqatavnnallkslprdyelkeesldprynikahygdsfeesyFGGKVGFLLAGAYKNewdfeerfs 302
Cdd:cd01347  141 A-------------------------------------------------------DDGAFGARLYGAYRD--------- 156
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 303 svitqdleneegnvdcttslatsedvsNSCYNTVKNSQVTTETESYNGSLSLSYRLgthsisaqqlyiidnedeseiais 382
Cdd:cd01347  157 ---------------------------GDGTIDGDGQADDSDEERYNVAGKLDWRP------------------------ 185
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 383 qspagsstfsiagdgiaNRNHEFNyeerqlnitqvmgqhtfldyfgigADWQYTEAKATTDIPTSADFEFRDTYNSDGSY 462
Cdd:cd01347  186 -----------------DDDTRLT------------------------LDAGYQDQDADGPGGTLPANGTGSSLGGGPSS 224
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 463 AGSTITGDDnrvimsYTNMEERVKSYGGNLTLPLSFESMEVefKVGYDFSDRARIFNTSSFAINNSGGSGISINDGSTDA 542
Cdd:cd01347  225 NTNGDRDWD------YRDRYRKRASLGLEHDLNDTGWTLRA--NLSYSYTDNDGDPLILNGGNNAAGGDLGRSGYSSERD 296
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 543 LNNSGFLTDdfidNNAVLVDFNEP----TAPDADDYIAAQKVDAGYASFDVFYDQWIRISGGIRYEEFKQSSIGTSSLIF 618
Cdd:cd01347  297 TTQLGFDAG----LNAPFGTGPVAhtltLGVEYRREELDEKQTALYAQDTIELTDDLTLTLGLRYDHYDQDSKDTIAGGT 372
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 619 DEDDlntFYDpdkiqagsvitdDWYPALSVTYVGGDDYQVRLGYGETVVRPDFREVVPvTYYDPLTDIRtfGRTGIKSSP 698
Cdd:cd01347  373 TAKK---SYS------------HWSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYG-GGSHGGTAAV--GNPNLKPEK 434
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 699 IKNYDLRYEYYGQAGNSFSVAAFYKDITAPIETVLNIGDEDYSASFINGETAEVYGIEAEWLQDLTfvsEGLFTSGNITL 778
Cdd:cd01347  435 SKQYELGLKYDPGDGLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGKARIRGVELEASYDLT---DGLGLTGSYTY 511
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 779 SDSEASIDPALAGtltnpKKRMTGHSEYVVNLQLNYDsldgmhssslvynVFGERILAAGVANRDDAYEQ---------- 848
Cdd:cd01347  512 TDTEVKRTDGATT-----GNRLPGIPKHTANLGLDYE-------------LPDEGLTAGGGVRYRGKQYAdtangnntvk 573
                        810       820       830       840       850       860
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490723786 849 --PFHSLDLVYTYYPDFNSKIKFKVKNLLDEDqEVTQSDIIVRS----KEQGVTFDLSYSYEF 905
Cdd:cd01347  574 vpGYTLVDLSASYQFTKNLTLRLGVNNLFDKD-YYTSLSVRGSGlygyYGPGRTYYLSVSYKF 635
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
40-885 1.22e-21

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 100.67  E-value: 1.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  40 IEEVVAVGTRLQGSAAAVveerknqAFVADILGSEQLSRTGDSDAASALRRVTGLTLVD----GKFIYVRGLGERYSSAR 115
Cdd:COG1629    1 LEEVVVTATRTDESLQDV-------PGSVSVISREQLEDQPATDLGDLLRRVPGVSVTSagggAGQISIRGFGGGGNRVL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 116 --LNGayIPSPDLTRNVIPLDIFPASIIESMAVQKAYSPDMPAAFG-GGNIDIRTKTAPSEFTAGIEVGAGydtassdgf 192
Cdd:COG1629   74 vlVDG--VPLNDPSGGDGGLSYIDPEDIERVEVLRGPSSALYGSGAlGGVINIVTKKPKDGKGGEVSASYG--------- 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 193 TYNRNEngipselsqaistYRGDFSIGNivssegfedgdltraeqatavnnallkslprdyelkeesldprynikahygd 272
Cdd:COG1629  143 SYGTYR-------------ASLSLSGGN---------------------------------------------------- 157
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 273 sfeesyfgGKVGFLLAGAYknewdfeerfssvitqdlENEEGNVDcttslatsedvsnscyntvknsqvTTETESYNGSL 352
Cdd:COG1629  158 --------GKLAYRLSASY------------------RDSDGYRD------------------------NSDSDRYNLRA 187
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 353 SLSYRLG-THSISAQ-QLYIIDNEDESEIAISQSPAGSSTFSIAGDGIANRNHEFNYeerqlnitqvmgqhtfldYFGIG 430
Cdd:COG1629  188 KLGYQLGdDTRLTLSaSYSDSDQDSPGYLTLAALRPRGAMDDGTNPYSNDTDDNTRD------------------RYSLS 249
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 431 ADWQYTEAKATTDIPTSADFEFRDTYNSDGSYAGSTITGDDnrvimsyTNMEERVKSYGGNLTLPLSFESmEVEFKVGYD 510
Cdd:COG1629  250 LEYEHLGDGLKLSASAYYRYDDTDLDSDFTPTPADGGTLEQ-------TDFDNRTYGLELRLTYDLGFGG-KHTLLVGLD 321
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 511 FSDRarifNTSSFAINNSGGSGisindgstdALNNSGFLTDDFIDNNAVlvdfneptapdaddyiaaqkvdAGYASFDVF 590
Cdd:COG1629  322 YQRQ----DLDGSGYPLDLGSG---------SLPTLTSGADDDGTTTSL----------------------ALYAQDTYK 366
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 591 YDQWIRISGGIRYEEFKQssigtsslifdedDLNTFYDPDKIQAGSVITDDWYPALSVTYVGGDDYQVRLGYGETVVRPD 670
Cdd:COG1629  367 LTDKLTLTAGLRYDYVSY-------------DVDDTVTGTDSASGSRSYSAFSPSLGLTYQLSPNLSLYASYSRGFRAPT 433
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 671 FREVvpvtyYDPLTDIRTFGRTGIKSSPIKNYDLRYEYYGQAGN-SFSVAAFYKDITAPIETVLNIGDEDYSASFINGET 749
Cdd:COG1629  434 FGEL-----YANGTDPYSVGNPDLKPETSTNYELGLRYRLLDGRlSLSLALFYSDVDNEILSVPLPNDSGFSTYYTNAGK 508
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 750 AEVYGIEAEWLQDLTfvsEGLFTSGNITLSDSEasIDPALAGTLTNPKKRMTGHSEYVVNLQLNYDSLDGMhSSSLVYNV 829
Cdd:COG1629  509 ARSYGVELELSYQLT---PGLSLNASYSYTDAK--FDDDTDGSADLDGNRLPGVPPLTANLGLTYEFPGGW-SLGLGVRY 582
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490723786 830 FGERILaaGVANRDDaYEQPFHSLDLVYTYYPDFNSKIKFKVKNLLDEDQEVTQSD 885
Cdd:COG1629  583 VGDRYL--DDANTQG-APGGYTLVDLGAGYRFGDNLTLSLGVDNLFDKKYATSLSV 635
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
425-904 3.33e-17

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 85.59  E-value: 3.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  425 DYFGIGADWQYTEAKATTDIPTSADFEFRDTYNSDGSYAGSTITGDDNRVIM-SYTNMEERVKSYGGNLTLPLSFESMEV 503
Cdd:pfam00593  13 TLLTLGYDYSRYTDGLDLGLTLDGYGNDGGYLGDRPLYYGRDYSDTDRKRLSlGYDYDLGDGLSWLSTLRLGLRYSSLDG 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  504 EFKVGYDFSDRARIFNTSSFAINNSGGSGISINDGSTDALNNSGFLTD----DFIDNNAVLVDFNEPTAPDADDYIAAQK 579
Cdd:pfam00593  93 DYTSNSSGLSGAGDYLSDDRLYGLYGLDGDLELSLDLSHDLLLGVELRtaglDYRRLDDDAYDPYDPANPSSSSYSDTTT 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  580 VDAG-YASFDVFYDQWIRISGGIRYEEFKQSSigtsslifdeddlntFYDPDKIQAGSVITDDWYPALSVTYVGGDDYQV 658
Cdd:pfam00593 173 DSYGlYLQDNIKLTDRLTLTLGLRYDHYSTDG---------------DDGNGGGDNFSRSYSAFSPRLGLVYKPTDNLSL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  659 RLGYGETVVRPDFREVVPvTYYDPLTDIRTFGRTGIKSSPIKNYDLRYEYYGQAGNsFSVAAFYKDITAPIETV-LNIGD 737
Cdd:pfam00593 238 YASYSRGFRAPSLGELYG-SGSGGGGGAVAGGNPDLKPETSDNYELGLKYDDGRLS-LSLALFYIDIKNLITSDpDGPGL 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  738 EDYSASFINGETAEVYGIEAEWLQDLtfvSEGLFTSGNITLSDSEASIDPALAGtltnpkKRMTGHSEYVVNLQLNYDSL 817
Cdd:pfam00593 316 GGTVYTYTNVGKARIRGVELELSGRL---WGLGLSGGGYTYTDADDDADADDTG------NPLPNVPRHTANLGLTYDFP 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  818 DGM--HSSSLVYNVFGERILaagvANRDDAYEQP-FHSLDLVYTYYPDFNSKIKFKVKNLLDEDQE---VTQSDIIVRSK 891
Cdd:pfam00593 387 LGGwgARLGARYVGSGERRY----GDAANTFKTPgYTLVDLSAGYRLNKNLTLRLGVNNLFDKYYKryySSGGGNLGGYP 462
                         490
                  ....*....|...
gi 490723786  892 EQGVTFDLSYSYE 904
Cdd:pfam00593 463 GPGRTFYLGLSYK 475
 
Name Accession Description Interval E-value
TonB-Xanth-Caul TIGR01782
TonB-dependent receptor; This model represents a family of TonB-dependent outer-membrane ...
40-880 1.18e-50

TonB-dependent receptor; This model represents a family of TonB-dependent outer-membrane receptors which are found mainly in Xanthomonas and Caulobacter. These appear to represent the expansion of a paralogous family in that the 22 X. axonopodis (21 in X. campestris) and 18 C. crescentus sequences are more closely related to each other than any of the many TonB-dependent receptors found in other species. In fact, the Crescentus and Xanthomonas sequences are inseparable on a phylogenetic tree using a PAM-weighted neighbor-joining method, indicating that one of the two genuses may have acquired this set of receptors from the other. The mechanism by which this family is shared between Xanthomonas, a gamma proteobacterial plant pathogen and Caulobacter, an alpha proteobacterial aquatic organism is unclear. [Transport and binding proteins, Porins]


Pssm-ID: 273804 [Multi-domain]  Cd Length: 845  Bit Score: 192.16  E-value: 1.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786   40 IEEVVAVGTRlqGSAAAVVEERKNQAFVADILGSEQLSRTGDSDAASALRRVTGLTLV----DGKFIYVRGLGERYSSAR 115
Cdd:TIGR01782   1 LDAVQVTGQR--ASLEKAIDAKRDADSVVDVISAEDIGKLPDVNVAEALQRVPGVSIErdqgEGRYVSVRGLGPSYNRTT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  116 LNGAYIPSPDLTRNVIPLDIFPASIIESMAVQKAYSPDMPAAFGGGNIDIRTKTA----PSEFTAGIEVGAgYDTASSDG 191
Cdd:TIGR01782  79 LNGRTIASTDSGGRAFSLDLLPSELVSGVEVYKTPTADMDEGGIGGTVDLRTRSPfdydGRTLSGSAQGGY-NDLAGKDK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  192 ftynrnengipselsqaiSTYRGDFSIGNIvssegFEDGDLtraeqatavnnallkslprdyelkeesldprynikahyg 271
Cdd:TIGR01782 158 ------------------PGPRGAASYSWT-----FGDGQF--------------------------------------- 175
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  272 dsfeesyfggkvGFLLAGAYknewdfeerfssvitQDLENEEGNV------DCTTSLATSEDVSNScyNTVKNSQVTTET 345
Cdd:TIGR01782 176 ------------GVLLSASY---------------QKRDFAEDNVetenwgTYTSADGGAQGLYFP--RGVRYRSYRNDR 226
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  346 ESYNGSLSLSYRLG-THSISAQQLYIIDNEDESEIAISQSPAGSSTFSIAGDGIANRN-------------HEFNYEERQ 411
Cdd:TIGR01782 227 ERKGVNGSLQWRPSdALELYLDTLYSKYDDDETRQQIEFRTLNGGSTVITSNQTATSGalvqgtvanlqilVEARYNEEK 306
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  412 LNITQVM--GQHTFlDYFGIGADWQYTEAKATTDIPTSA---------DFEFR---------DTYNSDGSYAGSTITGDD 471
Cdd:TIGR01782 307 ETTTSLTlgGEWTG-DRWTLDGDLGYSKATRDRPDRVTRfftaptpgyDFDYRggptltlgtPADGDDASNYTNPANGEL 385
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  472 NRVIMSYTNMEERVKSyggnLTLPLSFESMEVEFKVGYDFSDRARIFNTSSFAINNSGGSGIS---------INDGSTDA 542
Cdd:TIGR01782 386 RRTQISYQKAEDSEDA----AQLDATFDGPFTSLKFGVRYRRRDKTNRGSRYRRSIIGATGASglagvpsdlAGAGLDGG 461
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  543 LNNSGFL---TDDFIDNNAVLVDFNEPTAPDADDYIAA-----QKVDAGYASFDVFYDQWIRISGGIRYEEFKQSSIGTS 614
Cdd:TIGR01782 462 LGGPLTGwdpADLDAFLNAARGDAAGGGTYTYASTAPNtytvtEDTTAAYAMANFDTGLRLRGNVGVRYERTDQTSDGWQ 541
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  615 SlifdeddlntfyDPDKIQAGSVIT--------DDWYPALSVTYVGGDDYQVRLGYGETVVRPDFREVVP-VTYYDPLTD 685
Cdd:TIGR01782 542 S------------QPAANGTGSVLVpvsadrdyTDVLPSLNLAYDLTDDLVLRFAASKTITRPDFGDLAAnTSLSDDGTG 609
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  686 IRTFGRTG---IKSSPIKNYDLRYEYYGQAGNSFSVAAFYKDI---------TAPIETVLNIGDEDYSAS-FINGETA-E 751
Cdd:TIGR01782 610 GTVTVSGGnpdLKPYESDNLDLSLEWYFGPGGLLSAAVFYKDIknfivtttsTETNDGGGGLVVAGVLVSrPVNGGKAgK 689
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  752 VYGIEAEWLQDLTFVS---EGLFTSGNITLSDSEASIDpalAGTLTNPKKRMTGHSEYVVNLQLNYDSldGMHSSSLVYN 828
Cdd:TIGR01782 690 IRGVELGYQQTFDFLPgplSGFGVQANYTYVDSEADPS---VDGVQRRKLPLPGLSKNTANATLYYEK--GGFSARLSYN 764
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 490723786  829 VFGERILAAGVAN--RDDAYEQPFHSLDLVYTYypDFNSKIK--FKVKNLLDEDQE 880
Cdd:TIGR01782 765 YRSDYLLDVGGSNinRLDRYVDPRGQLDLSASY--QVSDHLSlgLQASNLTNEPSR 818
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
69-905 2.06e-25

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 112.54  E-value: 2.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  69 DILGSEQLSRTGDSDAASALRRVTGLTLVDG-----KFIYVRGLGERYSSARLNGAYIPSPDLTRNViPLDIFPASIIES 143
Cdd:cd01347    3 SVITAEDIEKQPATSLADLLRRIPGVSVTRGgggggSTISIRGFGPDRTLVLVDGLPLASSNYGRGV-DLNTIPPELIER 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 144 MAVQKAYSPDMPAAFG-GGNIDIRTKTAPSEFtaGIEVGAGYDTASSDgftynrnengipselsqaiSTYRGDFSIGNIV 222
Cdd:cd01347   82 VEVLKGPSSALYGSGAiGGVVNIITKRPTDEF--GGSVTAGYGSDNSG-------------------SSGGGGFDVSGAL 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 223 SsegfedgdltraeqatavnnallkslprdyelkeesldprynikahygdsfeesyFGGKVGFLLAGAYKNewdfeerfs 302
Cdd:cd01347  141 A-------------------------------------------------------DDGAFGARLYGAYRD--------- 156
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 303 svitqdleneegnvdcttslatsedvsNSCYNTVKNSQVTTETESYNGSLSLSYRLgthsisaqqlyiidnedeseiais 382
Cdd:cd01347  157 ---------------------------GDGTIDGDGQADDSDEERYNVAGKLDWRP------------------------ 185
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 383 qspagsstfsiagdgiaNRNHEFNyeerqlnitqvmgqhtfldyfgigADWQYTEAKATTDIPTSADFEFRDTYNSDGSY 462
Cdd:cd01347  186 -----------------DDDTRLT------------------------LDAGYQDQDADGPGGTLPANGTGSSLGGGPSS 224
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 463 AGSTITGDDnrvimsYTNMEERVKSYGGNLTLPLSFESMEVefKVGYDFSDRARIFNTSSFAINNSGGSGISINDGSTDA 542
Cdd:cd01347  225 NTNGDRDWD------YRDRYRKRASLGLEHDLNDTGWTLRA--NLSYSYTDNDGDPLILNGGNNAAGGDLGRSGYSSERD 296
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 543 LNNSGFLTDdfidNNAVLVDFNEP----TAPDADDYIAAQKVDAGYASFDVFYDQWIRISGGIRYEEFKQSSIGTSSLIF 618
Cdd:cd01347  297 TTQLGFDAG----LNAPFGTGPVAhtltLGVEYRREELDEKQTALYAQDTIELTDDLTLTLGLRYDHYDQDSKDTIAGGT 372
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 619 DEDDlntFYDpdkiqagsvitdDWYPALSVTYVGGDDYQVRLGYGETVVRPDFREVVPvTYYDPLTDIRtfGRTGIKSSP 698
Cdd:cd01347  373 TAKK---SYS------------HWSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYG-GGSHGGTAAV--GNPNLKPEK 434
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 699 IKNYDLRYEYYGQAGNSFSVAAFYKDITAPIETVLNIGDEDYSASFINGETAEVYGIEAEWLQDLTfvsEGLFTSGNITL 778
Cdd:cd01347  435 SKQYELGLKYDPGDGLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGKARIRGVELEASYDLT---DGLGLTGSYTY 511
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 779 SDSEASIDPALAGtltnpKKRMTGHSEYVVNLQLNYDsldgmhssslvynVFGERILAAGVANRDDAYEQ---------- 848
Cdd:cd01347  512 TDTEVKRTDGATT-----GNRLPGIPKHTANLGLDYE-------------LPDEGLTAGGGVRYRGKQYAdtangnntvk 573
                        810       820       830       840       850       860
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490723786 849 --PFHSLDLVYTYYPDFNSKIKFKVKNLLDEDqEVTQSDIIVRS----KEQGVTFDLSYSYEF 905
Cdd:cd01347  574 vpGYTLVDLSASYQFTKNLTLRLGVNNLFDKD-YYTSLSVRGSGlygyYGPGRTYYLSVSYKF 635
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
40-885 1.22e-21

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 100.67  E-value: 1.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  40 IEEVVAVGTRLQGSAAAVveerknqAFVADILGSEQLSRTGDSDAASALRRVTGLTLVD----GKFIYVRGLGERYSSAR 115
Cdd:COG1629    1 LEEVVVTATRTDESLQDV-------PGSVSVISREQLEDQPATDLGDLLRRVPGVSVTSagggAGQISIRGFGGGGNRVL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 116 --LNGayIPSPDLTRNVIPLDIFPASIIESMAVQKAYSPDMPAAFG-GGNIDIRTKTAPSEFTAGIEVGAGydtassdgf 192
Cdd:COG1629   74 vlVDG--VPLNDPSGGDGGLSYIDPEDIERVEVLRGPSSALYGSGAlGGVINIVTKKPKDGKGGEVSASYG--------- 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 193 TYNRNEngipselsqaistYRGDFSIGNivssegfedgdltraeqatavnnallkslprdyelkeesldprynikahygd 272
Cdd:COG1629  143 SYGTYR-------------ASLSLSGGN---------------------------------------------------- 157
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 273 sfeesyfgGKVGFLLAGAYknewdfeerfssvitqdlENEEGNVDcttslatsedvsnscyntvknsqvTTETESYNGSL 352
Cdd:COG1629  158 --------GKLAYRLSASY------------------RDSDGYRD------------------------NSDSDRYNLRA 187
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 353 SLSYRLG-THSISAQ-QLYIIDNEDESEIAISQSPAGSSTFSIAGDGIANRNHEFNYeerqlnitqvmgqhtfldYFGIG 430
Cdd:COG1629  188 KLGYQLGdDTRLTLSaSYSDSDQDSPGYLTLAALRPRGAMDDGTNPYSNDTDDNTRD------------------RYSLS 249
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 431 ADWQYTEAKATTDIPTSADFEFRDTYNSDGSYAGSTITGDDnrvimsyTNMEERVKSYGGNLTLPLSFESmEVEFKVGYD 510
Cdd:COG1629  250 LEYEHLGDGLKLSASAYYRYDDTDLDSDFTPTPADGGTLEQ-------TDFDNRTYGLELRLTYDLGFGG-KHTLLVGLD 321
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 511 FSDRarifNTSSFAINNSGGSGisindgstdALNNSGFLTDDFIDNNAVlvdfneptapdaddyiaaqkvdAGYASFDVF 590
Cdd:COG1629  322 YQRQ----DLDGSGYPLDLGSG---------SLPTLTSGADDDGTTTSL----------------------ALYAQDTYK 366
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 591 YDQWIRISGGIRYEEFKQssigtsslifdedDLNTFYDPDKIQAGSVITDDWYPALSVTYVGGDDYQVRLGYGETVVRPD 670
Cdd:COG1629  367 LTDKLTLTAGLRYDYVSY-------------DVDDTVTGTDSASGSRSYSAFSPSLGLTYQLSPNLSLYASYSRGFRAPT 433
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 671 FREVvpvtyYDPLTDIRTFGRTGIKSSPIKNYDLRYEYYGQAGN-SFSVAAFYKDITAPIETVLNIGDEDYSASFINGET 749
Cdd:COG1629  434 FGEL-----YANGTDPYSVGNPDLKPETSTNYELGLRYRLLDGRlSLSLALFYSDVDNEILSVPLPNDSGFSTYYTNAGK 508
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 750 AEVYGIEAEWLQDLTfvsEGLFTSGNITLSDSEasIDPALAGTLTNPKKRMTGHSEYVVNLQLNYDSLDGMhSSSLVYNV 829
Cdd:COG1629  509 ARSYGVELELSYQLT---PGLSLNASYSYTDAK--FDDDTDGSADLDGNRLPGVPPLTANLGLTYEFPGGW-SLGLGVRY 582
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490723786 830 FGERILaaGVANRDDaYEQPFHSLDLVYTYYPDFNSKIKFKVKNLLDEDQEVTQSD 885
Cdd:COG1629  583 VGDRYL--DDANTQG-APGGYTLVDLGAGYRFGDNLTLSLGVDNLFDKKYATSLSV 635
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
16-862 7.74e-20

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 94.54  E-value: 7.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  16 LGLVAHSTSLIAAQADEQLT-NEQEIEEVVAVGTRLQgsaaavvEERKNQAFVADILGSEQLSRTGDSDAASALRRVTGL 94
Cdd:COG4771    2 LLASLLLLLALAAQAADALAeDATELEEVVVTATRTE-------QSLSDAPASVSVITAEEIEKLGATDLADALRLLPGV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  95 TLVD------GKFIYVRGLGERYSSARLNGAYIPSPDLTrNVIPLDIFPASIIESMAVQKaySPdMPAAFG----GGNID 164
Cdd:COG4771   75 SVTRsggrggSSGISIRGLGGDRVLVLIDGVPVNNPALG-GGGDLSYIPPDDIERIEVIR--GP-ASALYGsdaiGGVIN 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 165 IRTKTAPSEFTAGIEVGAGydtassdgftynrnengipselSQAISTYRGDFSIGnivssegfedgdltraeqatavnna 244
Cdd:COG4771  151 IITKKPTDELEGSVSLGYG----------------------SNGNGTYSGSLSLG------------------------- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 245 llkslprdyelkeesldprynikahygdsfeesYFGGKVGFLLAGAYknewdfeerfssvitqdlENEEGNVDcttslat 324
Cdd:COG4771  184 ---------------------------------GPGDKLSFLLSGSY------------------RDRDGYLD------- 205
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 325 sedvsnscyNTVKNSQVTTETESYNGSLSLSYRLG-THSISAQQLYIIDNEDESEIAISQSPAGSSTFSIAGDGIANRNH 403
Cdd:COG4771  206 ---------YRNGGFVGNSGYERYNLNAKLGYRLSdNHRLSLSGGYSRQDRDGGPPTLGDTEISSDNAGDRDTTTDRGNY 276
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 404 EFNYeerqlnitqvmgQHTFLDYFGIGADWQYTEAKATTDIPTSADFEFRDTynsdgsyagstitgddnrvimsytnmee 483
Cdd:COG4771  277 SLRY------------NGDLGDNLDLSLYYSRTDRDSTNGSLGGSTGSFSDS---------------------------- 316
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 484 RVKSYGGNLTLPLSFeSMEVEFKVGYDFsdrarifntssfaINNSGGSGISINDGSTDALNNSGFLTDDFidnnavlvDF 563
Cdd:COG4771  317 DDTTYGLELDLTYPL-GGNHTLTLGAEY-------------RYDDLDSSSFLGGADASRDTYGLFAQDEW--------KL 374
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 564 NEptapdaddyiaaqkvdagyasfdvfydqWIRISGGIRYEEFKQSsigtsslifdeddlntfydpdkiqaGSVITDDWY 643
Cdd:COG4771  375 TD----------------------------KLTLTAGLRYDYYSTF-------------------------GASNYTAFS 401
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 644 PALSVTYVGGDDYQVRLGYGETVVRPDFREVVPvtYYDPLTDIRTFGRTGIKSSPIKNYDLRYEYYGQAGN-SFSVAAFY 722
Cdd:COG4771  402 PRLGLRYDLSDNLTLRASYGRGFRAPSLAELYG--SGTGTPGRYVLGNPDLKPETSDNYELGLEYRLGNGGlSLSLTGFY 479
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 723 KDITAPIETVLNIGDEDYSASFINGETAEVYGIEAEWLQDLTfvsEGLFTSGNITLSDSEASIDpalagtltNPKKRMTG 802
Cdd:COG4771  480 TDIKDLIVLVPVGPGPGDVLQYENVGKARTYGLELELKYRLG---KGLTLTASYTYLDSKIDDG--------DTGEPLPN 548
                        810       820       830       840       850       860
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 803 HSEYVVNLQLNYDSLDGMHSSSLVYNVFGERILAagVANRDDAYEQPFHSLDLVYTYYPD 862
Cdd:COG4771  549 VPPHKANLGLDYRLPKWWLLLLLTRYYGGRYVTP--PSGRLEGYTPGYTLLDLRASYKLT 606
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
425-904 3.33e-17

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 85.59  E-value: 3.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  425 DYFGIGADWQYTEAKATTDIPTSADFEFRDTYNSDGSYAGSTITGDDNRVIM-SYTNMEERVKSYGGNLTLPLSFESMEV 503
Cdd:pfam00593  13 TLLTLGYDYSRYTDGLDLGLTLDGYGNDGGYLGDRPLYYGRDYSDTDRKRLSlGYDYDLGDGLSWLSTLRLGLRYSSLDG 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  504 EFKVGYDFSDRARIFNTSSFAINNSGGSGISINDGSTDALNNSGFLTD----DFIDNNAVLVDFNEPTAPDADDYIAAQK 579
Cdd:pfam00593  93 DYTSNSSGLSGAGDYLSDDRLYGLYGLDGDLELSLDLSHDLLLGVELRtaglDYRRLDDDAYDPYDPANPSSSSYSDTTT 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  580 VDAG-YASFDVFYDQWIRISGGIRYEEFKQSSigtsslifdeddlntFYDPDKIQAGSVITDDWYPALSVTYVGGDDYQV 658
Cdd:pfam00593 173 DSYGlYLQDNIKLTDRLTLTLGLRYDHYSTDG---------------DDGNGGGDNFSRSYSAFSPRLGLVYKPTDNLSL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  659 RLGYGETVVRPDFREVVPvTYYDPLTDIRTFGRTGIKSSPIKNYDLRYEYYGQAGNsFSVAAFYKDITAPIETV-LNIGD 737
Cdd:pfam00593 238 YASYSRGFRAPSLGELYG-SGSGGGGGAVAGGNPDLKPETSDNYELGLKYDDGRLS-LSLALFYIDIKNLITSDpDGPGL 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  738 EDYSASFINGETAEVYGIEAEWLQDLtfvSEGLFTSGNITLSDSEASIDPALAGtltnpkKRMTGHSEYVVNLQLNYDSL 817
Cdd:pfam00593 316 GGTVYTYTNVGKARIRGVELELSGRL---WGLGLSGGGYTYTDADDDADADDTG------NPLPNVPRHTANLGLTYDFP 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  818 DGM--HSSSLVYNVFGERILaagvANRDDAYEQP-FHSLDLVYTYYPDFNSKIKFKVKNLLDEDQE---VTQSDIIVRSK 891
Cdd:pfam00593 387 LGGwgARLGARYVGSGERRY----GDAANTFKTPgYTLVDLSAGYRLNKNLTLRLGVNNLFDKYYKryySSGGGNLGGYP 462
                         490
                  ....*....|...
gi 490723786  892 EQGVTFDLSYSYE 904
Cdd:pfam00593 463 GPGRTFYLGLSYK 475
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
486-878 9.86e-13

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 71.88  E-value: 9.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 486 KSYGG--NLTLPLSFESMEVEFKVGYDF----SDRARIFNTSSFAINNSGGSgisiNDGSTDALNNSGFLTDDFIdnnav 559
Cdd:COG4772  320 RSYGIepRLTHRFELGGVPHTLEVGLRYhreeEDRKQYVNTYGQGRSGAGLR----RDRRFSADALAAYAQNRFE----- 390
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 560 lvdfneptapdaddyiaaqkvdagyasfdvFYDQWiRISGGIRYEEFKQSSIGTSSLIFDEDDlntfydpdkiqAGSVIT 639
Cdd:COG4772  391 ------------------------------LTGRL-TLTPGLRYEHIRRDRTDRYSTRTGGDD-----------SGSNSY 428
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 640 DDWYPALSVTYVGGDDYQVRLGYGETVVRPDFREVVpvtyydpltdIRTFGRTGIKSSPIKNYDLRYEYYGQAGNSFSVA 719
Cdd:COG4772  429 SEFLPGLGLLYQLTDNLQLYANVSRGFEPPTFGDLA----------YGNGGNPDLKPEKSWNYELGTRGRIGNGLSAEVA 498
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 720 AFYKDITAPIETVLNIGDEDysASFINGETAEVYGIEAEWLQDL-TFVSEGLFTSGNITLSDSE--ASIDPALAGtltnp 796
Cdd:COG4772  499 LFYIDYDNELGSCSAAGGDR--STFTNAGETRHQGLELALDYDLlKGGGLGLPLFAAYTYTDAEftSDFGPVFAG----- 571
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 797 kKRMTGHSEYVVNLQLNYD------SLDGMHSSSlVYNVFGERiLAAGVANRDDAYeqpfHSLDLV--YTYYPDFnsKIK 868
Cdd:COG4772  572 -NRLPYVPRHQLTAGLGYEhggwtaNLNGRYVSE-QFTDAANT-VADGSFGKIPSY----TVLDLSasYDFGKNL--SLF 642
                        410
                 ....*....|
gi 490723786 869 FKVKNLLDED 878
Cdd:COG4772  643 AGVNNLFDKR 652
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
62-163 4.38e-08

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 51.89  E-value: 4.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786   62 KNQAFVADILGSEQLSRTGDSDAASALRRVTGLTLVDG-----KFIYVRGLGERYSSARLNGayIPSPDLTRNVIPLDIF 136
Cdd:pfam07715   3 RDTPGSVSVVTAEDIEDQGATNLADALRGVPGVSVSSGgggggSSISIRGFGSNRVLVLVDG--VPLNSGGGGSVDLNSI 80
                          90       100
                  ....*....|....*....|....*..
gi 490723786  137 PASIIESMAVQKAYSpdmPAAFGGGNI 163
Cdd:pfam07715  81 DPEDIERVEVLKGPA---SALYGSGAI 104
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
43-215 5.68e-06

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 49.10  E-value: 5.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  43 VVAVGTRLQgsaaavvEERKNQAFVADILGSEQLSRTGDSDAASALRRVTGLTLVD------GKFIYVRGLGERYSSARL 116
Cdd:COG4206    1 VVVTATRLE-------QSKSDLTGSVTVIDAEELERSGATSLADALRRVPGVQVSSsggpgsAASISIRGLGSNQTLVLI 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786 117 NGayIPSPDLTRNVIPLDIFPASIIESMAVQKAYSpdmPAAFG----GGNIDIRTKTAPSEFTAGIEVGAGYDTASSDGF 192
Cdd:COG4206   74 DG--VPLNDPSLGGVDLSLIPPDDIERIEVLKGAA---SALYGsdaiGGVINITTKKGKKGFKGSVSASYGSFGTRRLSA 148
                        170       180
                 ....*....|....*....|...
gi 490723786 193 TYNRNENGIpsELSQAISTYRGD 215
Cdd:COG4206  149 SLSGGAGKF--SYSLSASYRRSD 169
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
445-905 4.36e-05

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 47.41  E-value: 4.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  445 PTSADFEFRDTYNSDGSYAGstitgddnrviMSYTNMEERVKSYGGNLTLPLSFESMEVEFKVGYDFSDRARIFNtssfa 524
Cdd:TIGR01783 259 DTDSNQVQASGYSSDGGLFG-----------RSLTVVNVKQDRVQIDAGLDGEFETGPIEHDLLLGVSYGQRTTN----- 322
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  525 iNNSGGSGISINDGSTDALNNSGFLTDDFidnnavlvdfnePTAPDADDYiaaQKVDAGYASFDVFYDQWIRISGGIRYE 604
Cdd:TIGR01783 323 -RFNNTGYPSDNIYSLTATSSARTDIGDS------------PKDRALSST---TKALNGVALQRILLADKWTLTLGGRYD 386
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  605 EFKQSSIGTSSLIFDEDDLNTFYdpdkiqagsvitddwyPALSVTYVGGDDYQVRLGYGEtvvrpDFRevvPVTYYDPLT 684
Cdd:TIGR01783 387 SVDVKSNNGVAGSTGKRDDSQFT----------------PSLGVAYKPTDDWSLYASYAE-----SFK---PGGYYPKGA 442
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  685 DirtFGRTGIKSSPIKNYDLRYEYYGQAGNSFSVAAFYKDITapietvlNIGDEDYSASFI--NGETAEVYGIEAEWLQD 762
Cdd:TIGR01783 443 G---NSGDILEPEKGKNYELGVRYDLGDSLLATAALFRITKD-------NQLVQDPVNGTFsvNAGKTRNRGVELEARGY 512
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  763 LTFvseGLFTSGNITLSDSEASIDPALagtlTNPKKRMTGHSEYVVNLQLNYDSLDGMHSSSLVYNVF--GERILAAGVA 840
Cdd:TIGR01783 513 LTP---GLSLSAGYTYTDAEFTEDTNG----DTQGNTVPFVPKHTASLWASYAPPVGDNGLTLGGGVQytGKAYVDGGNT 585
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  841 NRDDAYEqpFHSLDLVYTYYPDFNSKIKFKVKNLLDED-----QEVTQSDIIVrsKEQGVTFDLSYSYEF 905
Cdd:TIGR01783 586 GKVPSYT--VVDLSVRYDLTKKKNLTLALNVNNLFDRDyytsgYRWGPSAYIY--PGAPRTVGLSVSYDF 651
OMP_b-brl_3 pfam14905
Outer membrane protein beta-barrel family; This family includes proteins annotated as TonB ...
431-814 1.09e-04

Outer membrane protein beta-barrel family; This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.


Pssm-ID: 434300 [Multi-domain]  Cd Length: 407  Bit Score: 45.73  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  431 ADWQYTeakaTTDIPTSADFEFRDTYNSDGSYAGSTITgddnrvimSYTNMEERVKSYGGNL--TLPLSFESMeveFKVG 508
Cdd:pfam14905  12 FDADYS----NYNNDSDSDYTNSDYNNPGGLEPFNDSL--------QRNNSPSNINIYTAQLdyTKPLGKKGK---LEAG 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  509 YDFSDRarifntssfaiNNSggsgisiNDGSTDALNNSGFLTDDFIDNnavlvdfneptapdadDYIAAQKVDAGYASFD 588
Cdd:pfam14905  77 AKYSFR-----------NND-------NDYDYENLDNGEWVPDPSRSN----------------DFDYKENIYAAYASYS 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  589 VFYDQWiRISGGIRYEefkQSSIGTSSLIFDEDDLNTFydpdkiqagsvitDDWYPALSVTYVGGDD--YQVRLGYGETV 666
Cdd:pfam14905 123 KKFGKW-SYQAGLRAE---YTDIDGDSVTTNETFKRNY-------------FNLFPSASLSYKLNDNnsLQLSLYYRRII 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490723786  667 VRPDFREVVP-VTYYDPLTdIRTfGRTGIKSSPIKNYDLRYEYYgqagNSFSVAAFYKDITAPIETVLNIGDED---YSa 742
Cdd:pfam14905 186 NRPSYWDLNPfRNYSDPYN-YSQ-GNPNLKPEYTNSFELGYTYK----WKLSLSLSYRYTNDVIQQTFITDDNDnvtYT- 258
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490723786  743 SFINGETAEVYGIEAEWLQDLTfvsEGLFTSGNITLSDSEASIDPALAGTLTNPKkrmtghseYVVNLQLNY 814
Cdd:pfam14905 259 TYENLGKSNSYGLELSASFNPT---KWWSLNGNLNGYYNKYKIDGSLNSDFSNFG--------FNWNLNNTF 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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