|
Name |
Accession |
Description |
Interval |
E-value |
| NhaP2 |
COG3263 |
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ... |
1-484 |
0e+00 |
|
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];
Pssm-ID: 442494 [Multi-domain] Cd Length: 502 Bit Score: 622.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 1 MFVIDNIILVSAILILLGVISSKLSARVGLPVLVLFLLVGMLAGEDGIAGISFDNAEAAHALGTLALAIILFDGGLQTPT 80
Cdd:COG3263 1 MDTLNLILLIGALLLLLSILASKLSSRLGVPLLLLFLGIGMLAGEDGLGGIQFDDAELAQLIGSLALAVILFDGGLRTRW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 81 SSIKQVWKPASALATVGVLLTAVITGLVATYILDLPVLQGVLLGAIVGSTDAAAVFALLRSAGIHLNKKLKSTLEIESAS 160
Cdd:COG3263 81 SSFRPVLAPALSLATLGVLLTAGLTGVFAHWLLGLSWLEGLLLGAIVSSTDAAAVFSILRSKGLNLKERLASTLELESGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 161 NDPMAIFLTVGLLEMLVNDMPIGLGLLQLFAQQMGVGAVCGFLIGKVSVWFINRIKLNASGLYLVMVTAFGLLSFGLSAT 240
Cdd:COG3263 161 NDPMAVFLTIALIELITGGGASGWSLLLLFVLQMGLGALVGLAGGWLGVWLLNRIRLPAEGLYPVLVLALALLAFGATAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 241 LGGSGFLAVFITGVILGNSKFVYKRGIFLFHDGLAWLGQITMFVVLGLLINPSSLVDVWLEGLLIALALIFVARPLAVAP 320
Cdd:COG3263 241 LGGSGFLAVYLAGLVLGNRRLPHKKSILRFHDGLAWLAQIGMFLMLGLLVFPSRLLPVALPALLIALFLIFVARPLAVFL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 321 ILKLFGFNNRETLFVSWVGLRGSVPIILAIFPLLFGLSGAELIFNVVFFVVLISATLQGSTMPWMAKKLSLIEPPPDLAA 400
Cdd:COG3263 321 SLLPFRFSWREKLFISWVGLRGAVPIVLATFPLLAGLPGAQLIFNVVFFVVLVSLLVQGTTLPPVARKLGLEVPPEPKPL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 401 ATLEITALNDIDIEIVEYTLSEVSRVSGRSLSHAALPESVVVAMITRGPSIIPPRGSTKLKPNDHLFVVLKPANRPFVDL 480
Cdd:COG3263 401 TRVELELLEELDAELVEYRVPPGSPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPPEDLEALER 480
|
....
gi 490724965 481 VFTA 484
Cdd:COG3263 481 LFAA 484
|
|
| PRK05326 |
PRK05326 |
potassium/proton antiporter; |
1-568 |
0e+00 |
|
potassium/proton antiporter;
Pssm-ID: 235410 [Multi-domain] Cd Length: 562 Bit Score: 595.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 1 MFVIDNIILVSAILILLGVISSKLSARVGLPVLVLFLLVGMLAGEDGIAGISFDNAEAAHALGTLALAIILFDGGLQTPT 80
Cdd:PRK05326 1 MDTINSLLLIGALLLLLSILASRLSSRLGIPSLLLFLAIGMLAGEDGLGGIQFDNYPLAYLVGNLALAVILFDGGLRTRW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 81 SSIKQVWKPASALATVGVLLTAVITGLVATYILDLPVLQGVLLGAIVGSTDAAAVFALLRSAGIHLNKKLKSTLEIESAS 160
Cdd:PRK05326 81 SSFRPALGPALSLATLGVLITAGLTGLFAHWLLGLDWLEGLLLGAIVGSTDAAAVFSLLRGKGLNLKERVASTLEIESGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 161 NDPMAIFLTVGLLEMLVN-DMPIGLGLLQLFAQQMGVGAVCGFLIGKVSVWFINRIKLNASGLYLVMVTAFGLLSFGLSA 239
Cdd:PRK05326 161 NDPMAVFLTITLIELITGgETGLSWGFLLLFLQQFGLGALIGLLGGWLLVQLLNRIALPAEGLYPILVLAGALLIFALTA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 240 TLGGSGFLAVFITGVILGNSKFVYKRGIFLFHDGLAWLGQITMFVVLGLLINPSSLVDVWLEGLLIALALIFVARPLAVA 319
Cdd:PRK05326 241 ALGGSGFLAVYLAGLVLGNRPIRHRHSILRFFDGLAWLAQIGMFLVLGLLVTPSRLLDIALPALLLALFLILVARPLAVF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 320 PILKLFGFNNRETLFVSWVGLRGSVPIILAIFPLLFGLSGAELIFNVVFFVVLISATLQGSTMPWMAKKLSLIEPPPDLA 399
Cdd:PRK05326 321 LSLLPFRFNLREKLFISWVGLRGAVPIVLATFPMMAGLPNAQLIFNVVFFVVLVSLLLQGTTLPWAARKLGVVVPPEARP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 400 AATLEITALNDIDIEIVEYTLSEVSRVSGRSLSHAALPESVVVAMITRGPSIIPPRGSTKLKPNDHLFVVLKPANRPFVD 479
Cdd:PRK05326 401 VSRVELDPLEESDAELLEYRVPAGSWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPALE 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 480 LVFTATDKTNHQDSHLarNELKVKGVTLVGDIFYSYHMKIDAPegiSLEEVINQKLSGEISKGSIVVIGNVQLRVITmvh 559
Cdd:PRK05326 481 RLFSQSPPGKLDQRFF--GDFILEGDAKLADLALIYGLELDQQ---TLGELIKQRLGGAPVVGDQVELGGIILTVAE--- 552
|
....*....
gi 490724965 560 TRIVTIGLK 568
Cdd:PRK05326 553 GRVTKVGLR 561
|
|
| Na_H_Exchanger |
pfam00999 |
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ... |
50-388 |
1.75e-35 |
|
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain] Cd Length: 377 Bit Score: 137.00 E-value: 1.75e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 50 GISFDNAEAAHALGTLALAIILFDGGLQTPTSSIKQVWKPASALATVGVLLTAVITG-LVATYILDLPVLQGVLLGAIVG 128
Cdd:pfam00999 39 GLISEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLLALLGVLIPFVLIGlLLYLLGLGIPLLEALLFGAILS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 129 STDAAAVFALLRSAGiHLNKKLKSTLEIESASNDPMAIFLTVGLLEMLVND-MPIGLGLLQLFAQQMGVGAVCGFLIGKV 207
Cdd:pfam00999 119 ATSPVVVLAILKELG-RVPERLGTLLLGESVLNDGVAVVLLAVLLALAQGVgGGSDLGWLLLIFLVVAVGGLLLGLLIGW 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 208 SVWFINRIKLNASGLYLVMVTAFGLLSFGLSATLGGSGFLAVFITGVILGNSKFvYKRGIFLFHDGLAWLGQITMFVVLG 287
Cdd:pfam00999 198 LLRLITRFTDDDRELEVLLVLLLALLAALLAEALGVSGILGAFLAGLVLSEYPF-ANKLSEKLEPFGYGLFNPLFFVLVG 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 288 LLINPSSLVDVWLEGLLIALALIFVARPLAVAPILKLFGFNNRETLFVSWVGL-RGSVPIILAIFPLLFGLSGAELiFNV 366
Cdd:pfam00999 277 LSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLLGLSLREALIIGFGGLqRGAVSLALAAIGPLLGIIAREL-YPL 355
|
330 340
....*....|....*....|..
gi 490724965 367 VFFVVLISATLQGSTMPWMAKK 388
Cdd:pfam00999 356 LIVVVLFTVLVQGITLKPLLFK 377
|
|
| a_cpa1 |
TIGR00831 |
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ... |
65-407 |
7.52e-18 |
|
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129911 [Multi-domain] Cd Length: 525 Bit Score: 86.86 E-value: 7.52e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 65 LALAIILFDGGLQTPTSSIKQVWKPASALATVGVLLTAVITGLVATYILDLPVLQGVLLGAIVGSTDAAAVFALLRSagI 144
Cdd:TIGR00831 54 LFLPPLLFEAAMNTDLRELRENFRPIALIAFLLVVVTTVVVGFSLNWILGIPLALALILGAVLSPTDAVAVLGTFKS--I 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 145 HLNKKLKSTLEIESASNDPMAIFLTVGLLEMLVNDMPIGLGLLQL-FAQQMGVGAVCGFLIGKVsVWFINRIKLNASGLY 223
Cdd:TIGR00831 132 RAPKKLSILLEGESLLNDGAALVVFAIAVAVALGKGVFDPLNAALdFAVVCVGGIAAGLAVGYL-AYRLLRAKIDDPLVE 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 224 LVMVTAFGLLSFGLSATLGGSGFLAVFITGVILGNSKFVYK-----RGIFL-FHDGLAWLGQITMFVVLGLLInPSSLVD 297
Cdd:TIGR00831 211 IALTILAPFAGFLLAERFHFSGVIAVVAAGLILTNYGRDFSmspttRLIALdFWSVIVFLVNGIIFILIGVQT-PGTIFS 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 298 VWLE---------------GLLIALALIFVARPLAVAPILKLF------GFNNRETLFVSWVGLRGSVPIILAI-FPLLF 355
Cdd:TIGR00831 290 AWKEilvapaavilalftnAFVIYPVMTYVRFLWTMKPFSNRFlkkkpmEFGTRWKHVVSWAGLRGAIPLALALsFPNQL 369
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 490724965 356 gLSGA-----ELIFNVVFFVVLISATLQGSTMPWMAKKlslIEPPPDLAAATLEITA 407
Cdd:TIGR00831 370 -LSGMafparYELVFLAAGVILFSLLVQGISLPIFVKR---KFVSEHSERELEEIIA 422
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NhaP2 |
COG3263 |
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ... |
1-484 |
0e+00 |
|
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];
Pssm-ID: 442494 [Multi-domain] Cd Length: 502 Bit Score: 622.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 1 MFVIDNIILVSAILILLGVISSKLSARVGLPVLVLFLLVGMLAGEDGIAGISFDNAEAAHALGTLALAIILFDGGLQTPT 80
Cdd:COG3263 1 MDTLNLILLIGALLLLLSILASKLSSRLGVPLLLLFLGIGMLAGEDGLGGIQFDDAELAQLIGSLALAVILFDGGLRTRW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 81 SSIKQVWKPASALATVGVLLTAVITGLVATYILDLPVLQGVLLGAIVGSTDAAAVFALLRSAGIHLNKKLKSTLEIESAS 160
Cdd:COG3263 81 SSFRPVLAPALSLATLGVLLTAGLTGVFAHWLLGLSWLEGLLLGAIVSSTDAAAVFSILRSKGLNLKERLASTLELESGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 161 NDPMAIFLTVGLLEMLVNDMPIGLGLLQLFAQQMGVGAVCGFLIGKVSVWFINRIKLNASGLYLVMVTAFGLLSFGLSAT 240
Cdd:COG3263 161 NDPMAVFLTIALIELITGGGASGWSLLLLFVLQMGLGALVGLAGGWLGVWLLNRIRLPAEGLYPVLVLALALLAFGATAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 241 LGGSGFLAVFITGVILGNSKFVYKRGIFLFHDGLAWLGQITMFVVLGLLINPSSLVDVWLEGLLIALALIFVARPLAVAP 320
Cdd:COG3263 241 LGGSGFLAVYLAGLVLGNRRLPHKKSILRFHDGLAWLAQIGMFLMLGLLVFPSRLLPVALPALLIALFLIFVARPLAVFL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 321 ILKLFGFNNRETLFVSWVGLRGSVPIILAIFPLLFGLSGAELIFNVVFFVVLISATLQGSTMPWMAKKLSLIEPPPDLAA 400
Cdd:COG3263 321 SLLPFRFSWREKLFISWVGLRGAVPIVLATFPLLAGLPGAQLIFNVVFFVVLVSLLVQGTTLPPVARKLGLEVPPEPKPL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 401 ATLEITALNDIDIEIVEYTLSEVSRVSGRSLSHAALPESVVVAMITRGPSIIPPRGSTKLKPNDHLFVVLKPANRPFVDL 480
Cdd:COG3263 401 TRVELELLEELDAELVEYRVPPGSPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPPEDLEALER 480
|
....
gi 490724965 481 VFTA 484
Cdd:COG3263 481 LFAA 484
|
|
| PRK05326 |
PRK05326 |
potassium/proton antiporter; |
1-568 |
0e+00 |
|
potassium/proton antiporter;
Pssm-ID: 235410 [Multi-domain] Cd Length: 562 Bit Score: 595.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 1 MFVIDNIILVSAILILLGVISSKLSARVGLPVLVLFLLVGMLAGEDGIAGISFDNAEAAHALGTLALAIILFDGGLQTPT 80
Cdd:PRK05326 1 MDTINSLLLIGALLLLLSILASRLSSRLGIPSLLLFLAIGMLAGEDGLGGIQFDNYPLAYLVGNLALAVILFDGGLRTRW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 81 SSIKQVWKPASALATVGVLLTAVITGLVATYILDLPVLQGVLLGAIVGSTDAAAVFALLRSAGIHLNKKLKSTLEIESAS 160
Cdd:PRK05326 81 SSFRPALGPALSLATLGVLITAGLTGLFAHWLLGLDWLEGLLLGAIVGSTDAAAVFSLLRGKGLNLKERVASTLEIESGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 161 NDPMAIFLTVGLLEMLVN-DMPIGLGLLQLFAQQMGVGAVCGFLIGKVSVWFINRIKLNASGLYLVMVTAFGLLSFGLSA 239
Cdd:PRK05326 161 NDPMAVFLTITLIELITGgETGLSWGFLLLFLQQFGLGALIGLLGGWLLVQLLNRIALPAEGLYPILVLAGALLIFALTA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 240 TLGGSGFLAVFITGVILGNSKFVYKRGIFLFHDGLAWLGQITMFVVLGLLINPSSLVDVWLEGLLIALALIFVARPLAVA 319
Cdd:PRK05326 241 ALGGSGFLAVYLAGLVLGNRPIRHRHSILRFFDGLAWLAQIGMFLVLGLLVTPSRLLDIALPALLLALFLILVARPLAVF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 320 PILKLFGFNNRETLFVSWVGLRGSVPIILAIFPLLFGLSGAELIFNVVFFVVLISATLQGSTMPWMAKKLSLIEPPPDLA 399
Cdd:PRK05326 321 LSLLPFRFNLREKLFISWVGLRGAVPIVLATFPMMAGLPNAQLIFNVVFFVVLVSLLLQGTTLPWAARKLGVVVPPEARP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 400 AATLEITALNDIDIEIVEYTLSEVSRVSGRSLSHAALPESVVVAMITRGPSIIPPRGSTKLKPNDHLFVVLKPANRPFVD 479
Cdd:PRK05326 401 VSRVELDPLEESDAELLEYRVPAGSWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPALE 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 480 LVFTATDKTNHQDSHLarNELKVKGVTLVGDIFYSYHMKIDAPegiSLEEVINQKLSGEISKGSIVVIGNVQLRVITmvh 559
Cdd:PRK05326 481 RLFSQSPPGKLDQRFF--GDFILEGDAKLADLALIYGLELDQQ---TLGELIKQRLGGAPVVGDQVELGGIILTVAE--- 552
|
....*....
gi 490724965 560 TRIVTIGLK 568
Cdd:PRK05326 553 GRVTKVGLR 561
|
|
| NhaP |
COG0025 |
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]; |
6-426 |
3.39e-64 |
|
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 439796 [Multi-domain] Cd Length: 506 Bit Score: 218.68 E-value: 3.39e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 6 NIILVSAILILLGVISSKLSARVGLPVLVLFLLVGMLAGedGIAGISFD-NAEAAHALGTLALAIILFDGGLQTPTSSIK 84
Cdd:COG0025 2 ELLLLILLLLLLGLLSQWLARRLKLPAPLLLLLAGILLG--PGLGLELDpELGDLEPLLELFLPPLLFEAALNLDLRELR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 85 QVWKPASALATVGVLLTAVITGLVATYILDLPVLQGVLLGAIVGSTDAAAVFALLRSAGihLNKKLKSTLEIESASNDPM 164
Cdd:COG0025 80 RNGRPILRLAVVGVLLTTLAVALAAHWLLGLPLAAALLLGAILAPTDPVAVSPILRRLG--VPKRLRTILEGESLLNDAT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 165 AIFLTVGLLEMLVNDMPIGLGLLQLFAQQMGVGAVCGFLIGKVSVWFINRIKLNASGLYLVMVTAFGllSFGLSATLGGS 244
Cdd:COG0025 158 ALVLFVLALAAALGGGFSLGEALLDFLLAILGGILVGLLLGWLLGRLLRRLPDPLLEILLTLALPFL--AYLLAEALHGS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 245 GFLAVFITGVILGNSKFV-----YKRGIFLFHDGLAWLGQITMFVVLGLLINPSSLVDVWLEGLLIALALIFVARPLAVA 319
Cdd:COG0025 236 GVLAVVVAGLVLGNAGRRslspeTRLQLLEFWETLEFLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWVF 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 320 PILKLFG--FNNRETLFVSWVGLRGSVPIILAIFPLL---FGLSGAELIFNVVFFVVLISATLQGSTMPWMAKKLSLIEP 394
Cdd:COG0025 316 LSLALRGsrLSWRERLFLSWGGPRGIVSLALALSLPLhggAGFPGRDLILALAFGVILLTLVLQGLTLPPLARRLGLRED 395
|
410 420 430
....*....|....*....|....*....|..
gi 490724965 395 PPdlAAATLEITALNDIDIEIVEYTLSEVSRV 426
Cdd:COG0025 396 EP--EGEELEAALARAALLELLAAELLADDEE 425
|
|
| Na_H_Exchanger |
pfam00999 |
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ... |
50-388 |
1.75e-35 |
|
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain] Cd Length: 377 Bit Score: 137.00 E-value: 1.75e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 50 GISFDNAEAAHALGTLALAIILFDGGLQTPTSSIKQVWKPASALATVGVLLTAVITG-LVATYILDLPVLQGVLLGAIVG 128
Cdd:pfam00999 39 GLISEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLLALLGVLIPFVLIGlLLYLLGLGIPLLEALLFGAILS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 129 STDAAAVFALLRSAGiHLNKKLKSTLEIESASNDPMAIFLTVGLLEMLVND-MPIGLGLLQLFAQQMGVGAVCGFLIGKV 207
Cdd:pfam00999 119 ATSPVVVLAILKELG-RVPERLGTLLLGESVLNDGVAVVLLAVLLALAQGVgGGSDLGWLLLIFLVVAVGGLLLGLLIGW 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 208 SVWFINRIKLNASGLYLVMVTAFGLLSFGLSATLGGSGFLAVFITGVILGNSKFvYKRGIFLFHDGLAWLGQITMFVVLG 287
Cdd:pfam00999 198 LLRLITRFTDDDRELEVLLVLLLALLAALLAEALGVSGILGAFLAGLVLSEYPF-ANKLSEKLEPFGYGLFNPLFFVLVG 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 288 LLINPSSLVDVWLEGLLIALALIFVARPLAVAPILKLFGFNNRETLFVSWVGL-RGSVPIILAIFPLLFGLSGAELiFNV 366
Cdd:pfam00999 277 LSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLLGLSLREALIIGFGGLqRGAVSLALAAIGPLLGIIAREL-YPL 355
|
330 340
....*....|....*....|..
gi 490724965 367 VFFVVLISATLQGSTMPWMAKK 388
Cdd:pfam00999 356 LIVVVLFTVLVQGITLKPLLFK 377
|
|
| a_cpa1 |
TIGR00831 |
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ... |
65-407 |
7.52e-18 |
|
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129911 [Multi-domain] Cd Length: 525 Bit Score: 86.86 E-value: 7.52e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 65 LALAIILFDGGLQTPTSSIKQVWKPASALATVGVLLTAVITGLVATYILDLPVLQGVLLGAIVGSTDAAAVFALLRSagI 144
Cdd:TIGR00831 54 LFLPPLLFEAAMNTDLRELRENFRPIALIAFLLVVVTTVVVGFSLNWILGIPLALALILGAVLSPTDAVAVLGTFKS--I 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 145 HLNKKLKSTLEIESASNDPMAIFLTVGLLEMLVNDMPIGLGLLQL-FAQQMGVGAVCGFLIGKVsVWFINRIKLNASGLY 223
Cdd:TIGR00831 132 RAPKKLSILLEGESLLNDGAALVVFAIAVAVALGKGVFDPLNAALdFAVVCVGGIAAGLAVGYL-AYRLLRAKIDDPLVE 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 224 LVMVTAFGLLSFGLSATLGGSGFLAVFITGVILGNSKFVYK-----RGIFL-FHDGLAWLGQITMFVVLGLLInPSSLVD 297
Cdd:TIGR00831 211 IALTILAPFAGFLLAERFHFSGVIAVVAAGLILTNYGRDFSmspttRLIALdFWSVIVFLVNGIIFILIGVQT-PGTIFS 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 298 VWLE---------------GLLIALALIFVARPLAVAPILKLF------GFNNRETLFVSWVGLRGSVPIILAI-FPLLF 355
Cdd:TIGR00831 290 AWKEilvapaavilalftnAFVIYPVMTYVRFLWTMKPFSNRFlkkkpmEFGTRWKHVVSWAGLRGAIPLALALsFPNQL 369
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 490724965 356 gLSGA-----ELIFNVVFFVVLISATLQGSTMPWMAKKlslIEPPPDLAAATLEITA 407
Cdd:TIGR00831 370 -LSGMafparYELVFLAAGVILFSLLVQGISLPIFVKR---KFVSEHSERELEEIIA 422
|
|
| KefB |
COG0475 |
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ... |
6-377 |
7.98e-15 |
|
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];
Pssm-ID: 440243 [Multi-domain] Cd Length: 384 Bit Score: 76.34 E-value: 7.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 6 NIILVSAILILLGVISSKLSARVGLPVLVLFLLVGMLAGEDGIAGISfdNAEAAHALGTLALAIILFDGGLQTPTSSIKQ 85
Cdd:COG0475 4 SLLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGLGLIE--DSEALELLAELGVVLLLFLIGLELDLKRLRK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 86 VWKPASALATVGVLLTAVITGLVAtYILDLPVLQGVLLGAIVGSTDAAAVFALLRSAGIhLNKKLKSTLEIESASNDPMA 165
Cdd:COG0475 82 MGRRALGIGLLQVLLPFLLGFLLA-LLLGLSLAAALFLGAALAATSTAIVLKVLKELGL-LKTPLGQLILGVALFDDIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 166 IFLtVGLLEMLVNDMPIGLGLLQLFAQQMGVGAVCGFLIGKVSVWFINRI-KLNASGLYLVMVTAFGLLSFGLSATLGGS 244
Cdd:COG0475 160 ILL-LALVPALAGGGSVAGSLLLALLKALLFLALLLLVGRYLLRRLFRLVaRTRSRELFLLFALLLVLLAAALAELLGLS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 245 GFLAVFITGVILGNSKfvYKRGIFLFHDGLAWLGQITMFVVLGLLINPSSLVDVWLEGLLIALALIfVARPLAVAPILKL 324
Cdd:COG0475 239 AALGAFLAGLVLAESE--YRHELEEKIEPFGDLFLPLFFVSVGLSLDLSALLSNPLLALLLVLAAI-VGKLLGAYLAARL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 490724965 325 FGFNNRETLFVsWVGL--RGSVPIILAIFPLLFGLSGAELiFNVVFFVVLISATL 377
Cdd:COG0475 316 FGLSRREALRI-GLLLapRGEFALVLASLGLSAGLISPEL-FAALVLVVLLTTLL 368
|
|
| trkA |
PRK09496 |
Trk system potassium transporter TrkA; |
405-474 |
2.18e-10 |
|
Trk system potassium transporter TrkA;
Pssm-ID: 236541 [Multi-domain] Cd Length: 453 Bit Score: 62.83 E-value: 2.18e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 405 ITALNDIDIEIVEYTLSEVSRVSGRSLSHAALPESVVVAMITRGPSIIPPRGSTKLKPNDHLFVVLKPAN 474
Cdd:PRK09496 370 VHSLRRGAAEAIEAVAHETSKVVGKPLKDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVFVLDKK 439
|
|
| b_cpa1 |
TIGR00840 |
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ... |
94-389 |
4.40e-10 |
|
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273294 [Multi-domain] Cd Length: 559 Bit Score: 62.49 E-value: 4.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 94 ATVGVLLTAVITGLVATYI--------LDLPVLQGVLLGAIVGSTDAAAVFALLrsAGIHLNKKLKSTLEIESASNDPMA 165
Cdd:TIGR00840 100 AVVGTLINAFVIGLSLYGIcliggfgsIDIGLLDNLLFGSLISAVDPVAVLAVF--EEYHVNEKLYIIIFGESLLNDAVT 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 166 IFL------TVGLLEMLVNDMPIGLGLLQLFAQQMGvGAVCGFLIGKVSVwFINRIKLNASGLYLVMVTAFGLLSFGLSA 239
Cdd:TIGR00840 178 VVLyntfikFHKTADEPVTIVDVFEGCASFFVVTCG-GLLVGVVFGFLVA-FITRFTHHIRQIEPLFVFLISYLSYLFAE 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 240 TLGGSGFLAVFITGVILgnSKFVYKR-------GIFLFHDGLAWLGQITMFVVLGL-LINPSSLVDvWLEgLLIALALIF 311
Cdd:TIGR00840 256 TLHLSGILALIFCGITM--KKYVEANmsrrsqtTIKYFMKMLSSLSETLIFIFLGVsLVTENHEWN-WAF-VVATLSFCV 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490724965 312 VARPLAVapiLKLFGFNNR---------ETLFVSWVGLRGSVPIILA------IFPLLFGLSGAELIfnVVFFVVLIsat 376
Cdd:TIGR00840 332 IYRVLGV---RTLSWITNEfrpveipykDQLVIFYAGLRGAVAFALAllldekIFPYKFLFVTTTLV--VVFFTVIF--- 403
|
330
....*....|...
gi 490724965 377 lQGSTMPWMAKKL 389
Cdd:TIGR00840 404 -QGGTIKPLVEVL 415
|
|
| TrkA_C |
pfam02080 |
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ... |
415-474 |
1.39e-07 |
|
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.
Pssm-ID: 460440 [Multi-domain] Cd Length: 70 Bit Score: 48.76 E-value: 1.39e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490724965 415 IVEYTLSEVSRVSGRSLSHAALPE--SVVVAMITRGPSIIPPRGSTKLKPNDHLFVVLKPAN 474
Cdd:pfam02080 1 LVEVTVPENSPLVGKTLKELNLPErfGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDD 62
|
|
| TrkA |
COG0569 |
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ... |
401-467 |
7.45e-07 |
|
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];
Pssm-ID: 440335 [Multi-domain] Cd Length: 296 Bit Score: 51.22 E-value: 7.45e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490724965 401 ATLEITALNDIDIEIVEYTLSEVSRVSGRSLSHAALPES--VVVAMITRGPSIIPPRGSTKLKPNDHLF 467
Cdd:COG0569 228 GVLDVLELADGDAEIVEVTVPEGSPLVGKTLKELDLRERygVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
|
|
| trkA |
PRK09496 |
Trk system potassium transporter TrkA; |
413-474 |
6.41e-05 |
|
Trk system potassium transporter TrkA;
Pssm-ID: 236541 [Multi-domain] Cd Length: 453 Bit Score: 45.50 E-value: 6.41e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490724965 413 IEIVEYTLSEVSRVSGRSLSHAA---LPESVVVAMITRGPSIIPPRGSTKLKPNDHLFVVLKPAN 474
Cdd:PRK09496 152 VQLVEVKVYEGSPLVGKPLSDLRehfPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREH 216
|
|
| |
