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Concise Results
Standard Results
Full Results
MULTISPECIES: insulinase family protein [Pseudoalteromonas]
Protein Classification
M16 family metallopeptidase ( domain architecture ID 1000463 )
M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)
List of domain hits
Name
Accession
Description
Interval
E-value
Ptr super family
cl34066 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
43-954
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
COG1025 :Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 963.93
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 43 SPND T R E Y KTL TL E N EIE V I LVSDP S A E KSAA S L S V G VG LLH DP MM QQG M AH Y LEHMLFLGT ER YP DTKG Y SD F MT K N GG 122
Cdd:COG1025 38 SPND P R Q Y RAI TL D N GLK V L LVSDP Q A D KSAA A L A V P VG SFD DP DD QQG L AH F LEHMLFLGT KK YP EPGE Y QE F IS K H GG 117
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 123 VN NA Y T WLDI TNY M F KIN NDA FD EALDRFADFF K AP KLY PEY A D K E K NAVNAE WSMR R EM D FFGQFKLARKMMG - D HP AN 201
Cdd:COG1025 118 SH NA S T ATER TNY Y F EVE NDA LE EALDRFADFF A AP LFD PEY V D R E R NAVNAE YTLK R SD D GRRIYQVHKETLN p A HP FS 197
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 202 RF LI GNLETL G DK E GS Q L HK E TVD FY NK YYS S N I MK VA L I SN LPIEQM E QK A KTY F AD I E N KHIEK P TV T AE L DFDKAG G 281
Cdd:COG1025 198 RF SV GNLETL S DK P GS K L RD E LLA FY QR YYS A N L MK LV L Y SN QSLDEL E KL A RQT F GA I P N RNLSV P PI T VP L YTPEQL G 277
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 282 KKVYYS P NEDVK QL Q LEF T I N NN ISDFAV KP NR Y V SYLL S NE MP GS PAQL L RDK G WVSQ L T A SPSP S q YG N Y G ALN IS LE 361
Cdd:COG1025 278 IIIHIV P LKPRR QL R LEF P I P NN QAYYRS KP LT Y I SYLL G NE GE GS LLDW L KKQ G LAES L S A GGGI S - GR N F G DFS IS VS 356
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 362 LTD E G MKN R ET I V A TIMQ YIELI KKE G VDAK YF N E IRTS L SNQ F K F L EK GDEFS YVS S L TGS M QD YP LNHAI DA P Y YYAK 441
Cdd:COG1025 357 LTD K G LAH R DE I I A AVFA YIELI RQQ G IQEW YF D E QAQL L ELA F R F Q EK TRPMD YVS W L SDN M LR YP VEDVL DA D Y LMDG 436
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 442 FD AE AI NEV L K QL NADTL R V W Y IS QQEE TD SQLHF YD GK Y RIED I SDAEI A S W - KT S SEFK L A LP SV N NLL P ES F AIKTA 520
Cdd:COG1025 437 FD PA AI RAR L A QL TPENA R I W L IS PDVP TD KTAYW YD TP Y SVDP I TQEQL A K W q QA S QNPA L S LP EL N PYI P DD F SLIKL 516
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 521 E f KE QKH PEL AY D KN G VKV W RQAS Q K F a A Q PK GLVEVYINTQPGLNDINAE VL YSVWAD L Y N IQQSQ LS TE A AI AG M S VN 600
Cdd:COG1025 517 D - KE SAK PEL LV D EP G LRL W YMPD Q Y F - A E PK ADIYLSLRNPQAVDSARNQ VL TRLLDY L L N DALNE LS YQ A SV AG L S YS 594
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 601 L APS - N GL V LS M SGFT D KQ DV LL KQA L SG L KA - DV T AQA F T QA IDRYK R G L L N QQ K QF PY A Q A F GAY S K L IRTGS F DT E A 678
Cdd:COG1025 595 L YAH q G GL T LS A SGFT Q KQ PK LL EAL L DQ L AS f EP T EER F A QA KSQLL R Q L D N AE K AK PY S Q L F SPL S R L LQPPY F ER E E 674
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 679 L IK A A ES LSVA DL NKLKTATFATND L RVFSY GN YNQQDIESI A TE L SAT L PS N H T s S E FA R SKAWLPQPGETRV L Q K DI D 758
Cdd:COG1025 675 L LA A L ES ITLQ DL RAFREQLLQQLH L EMLVV GN LSEEQAKQL A DS L KKQ L AP N G T - G E EP R RQVVDLDKSGSLN L E K AC D 753
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 759 VA D V A VVDMTVHPVPGYKQK A QAAV L QSHFRTIA F DKM RTEEQL A Y A VGA LAR P IEDYSAI G LFI Q T PV KG P KEIQA R F D 838
Cdd:COG1025 754 HT D S A LLIYYQSGYDSLASM A LSSL L GQIISPWF F NQL RTEEQL G Y V VGA GYM P LGRQPGL G FYV Q S PV AS P AYLLE R I D 833
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 839 Q F K K EYAVE L DNM S LDT FAQ L K NATLVS L K E QPK NLS D E MGP L IT D WYREN F N FD SKQ KLI DE V E K V T LE D IKQYYK Q TM 918
Cdd:COG1025 834 D F L K QFEER L LAL S EEE FAQ Y K QGLINQ L L E PDQ NLS E E AQR L WV D IGNGD F E FD TRE KLI AA V K K L T RA D LIDFFQ Q AV 913
890 900 910
....*....|....*....|....*....|....*.
gi 490726222 919 LN PQ AA RL NV Q LR GTK F ve S DFAD L PNQTK I QSLET 954
Cdd:COG1025 914 IA PQ GL RL LS Q SQ GTK H -- S KADE L KGWKT I TDISA 947
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
43-954
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 963.93
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 43 SPND T R E Y KTL TL E N EIE V I LVSDP S A E KSAA S L S V G VG LLH DP MM QQG M AH Y LEHMLFLGT ER YP DTKG Y SD F MT K N GG 122
Cdd:COG1025 38 SPND P R Q Y RAI TL D N GLK V L LVSDP Q A D KSAA A L A V P VG SFD DP DD QQG L AH F LEHMLFLGT KK YP EPGE Y QE F IS K H GG 117
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 123 VN NA Y T WLDI TNY M F KIN NDA FD EALDRFADFF K AP KLY PEY A D K E K NAVNAE WSMR R EM D FFGQFKLARKMMG - D HP AN 201
Cdd:COG1025 118 SH NA S T ATER TNY Y F EVE NDA LE EALDRFADFF A AP LFD PEY V D R E R NAVNAE YTLK R SD D GRRIYQVHKETLN p A HP FS 197
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 202 RF LI GNLETL G DK E GS Q L HK E TVD FY NK YYS S N I MK VA L I SN LPIEQM E QK A KTY F AD I E N KHIEK P TV T AE L DFDKAG G 281
Cdd:COG1025 198 RF SV GNLETL S DK P GS K L RD E LLA FY QR YYS A N L MK LV L Y SN QSLDEL E KL A RQT F GA I P N RNLSV P PI T VP L YTPEQL G 277
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 282 KKVYYS P NEDVK QL Q LEF T I N NN ISDFAV KP NR Y V SYLL S NE MP GS PAQL L RDK G WVSQ L T A SPSP S q YG N Y G ALN IS LE 361
Cdd:COG1025 278 IIIHIV P LKPRR QL R LEF P I P NN QAYYRS KP LT Y I SYLL G NE GE GS LLDW L KKQ G LAES L S A GGGI S - GR N F G DFS IS VS 356
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 362 LTD E G MKN R ET I V A TIMQ YIELI KKE G VDAK YF N E IRTS L SNQ F K F L EK GDEFS YVS S L TGS M QD YP LNHAI DA P Y YYAK 441
Cdd:COG1025 357 LTD K G LAH R DE I I A AVFA YIELI RQQ G IQEW YF D E QAQL L ELA F R F Q EK TRPMD YVS W L SDN M LR YP VEDVL DA D Y LMDG 436
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 442 FD AE AI NEV L K QL NADTL R V W Y IS QQEE TD SQLHF YD GK Y RIED I SDAEI A S W - KT S SEFK L A LP SV N NLL P ES F AIKTA 520
Cdd:COG1025 437 FD PA AI RAR L A QL TPENA R I W L IS PDVP TD KTAYW YD TP Y SVDP I TQEQL A K W q QA S QNPA L S LP EL N PYI P DD F SLIKL 516
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 521 E f KE QKH PEL AY D KN G VKV W RQAS Q K F a A Q PK GLVEVYINTQPGLNDINAE VL YSVWAD L Y N IQQSQ LS TE A AI AG M S VN 600
Cdd:COG1025 517 D - KE SAK PEL LV D EP G LRL W YMPD Q Y F - A E PK ADIYLSLRNPQAVDSARNQ VL TRLLDY L L N DALNE LS YQ A SV AG L S YS 594
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 601 L APS - N GL V LS M SGFT D KQ DV LL KQA L SG L KA - DV T AQA F T QA IDRYK R G L L N QQ K QF PY A Q A F GAY S K L IRTGS F DT E A 678
Cdd:COG1025 595 L YAH q G GL T LS A SGFT Q KQ PK LL EAL L DQ L AS f EP T EER F A QA KSQLL R Q L D N AE K AK PY S Q L F SPL S R L LQPPY F ER E E 674
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 679 L IK A A ES LSVA DL NKLKTATFATND L RVFSY GN YNQQDIESI A TE L SAT L PS N H T s S E FA R SKAWLPQPGETRV L Q K DI D 758
Cdd:COG1025 675 L LA A L ES ITLQ DL RAFREQLLQQLH L EMLVV GN LSEEQAKQL A DS L KKQ L AP N G T - G E EP R RQVVDLDKSGSLN L E K AC D 753
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 759 VA D V A VVDMTVHPVPGYKQK A QAAV L QSHFRTIA F DKM RTEEQL A Y A VGA LAR P IEDYSAI G LFI Q T PV KG P KEIQA R F D 838
Cdd:COG1025 754 HT D S A LLIYYQSGYDSLASM A LSSL L GQIISPWF F NQL RTEEQL G Y V VGA GYM P LGRQPGL G FYV Q S PV AS P AYLLE R I D 833
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 839 Q F K K EYAVE L DNM S LDT FAQ L K NATLVS L K E QPK NLS D E MGP L IT D WYREN F N FD SKQ KLI DE V E K V T LE D IKQYYK Q TM 918
Cdd:COG1025 834 D F L K QFEER L LAL S EEE FAQ Y K QGLINQ L L E PDQ NLS E E AQR L WV D IGNGD F E FD TRE KLI AA V K K L T RA D LIDFFQ Q AV 913
890 900 910
....*....|....*....|....*....|....*.
gi 490726222 919 LN PQ AA RL NV Q LR GTK F ve S DFAD L PNQTK I QSLET 954
Cdd:COG1025 914 IA PQ GL RL LS Q SQ GTK H -- S KADE L KGWKT I TDISA 947
PRK15101
PRK15101 protease3; Provisional
43-963
0e+00
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 636.63
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 43 S PN D T R E Y KTLT L E N EIE V I LVSDP S A E KS A A S L SVG VG L L H DP MM QQG M AHYLEHM LFL G TER YP DTKGYSD F MT K N GG 122
Cdd:PRK15101 37 S EK D P R Q Y QAIR L D N GMT V L LVSDP Q A V KS L A A L ALP VG S L E DP DA QQG L AHYLEHM VLM G SKK YP QPDSLAE F LK K H GG 116
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 123 VN NA Y T WLDI T NYMFKIN NDA FDE A L DR F AD FFKA P K L Y P EY AD K E K NAVNAE WS M R R EM D -- FFG Q FKLA r KMMGD HP A 200
Cdd:PRK15101 117 SH NA S T ASYR T AFYLEVE NDA LPP A V DR L AD AIAE P L L D P KN AD R E R NAVNAE LT M A R SR D gm RMA Q VSAE - TINPA HP G 195
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 201 N RF LI GNLETL G DK E GS Q L HKET VDFY NK YYS S N I MK VALI SN L P IEQMEQK A KTY F ADIE NK HIEK P TV T AELDF D KAG 280
Cdd:PRK15101 196 S RF SG GNLETL S DK P GS K L QDAL VDFY QR YYS A N L MK AVIY SN Q P LPELAKL A ADT F GRVP NK NASV P EI T VPVVT D AQK 275
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 281 G KKVY Y S P NEDV K Q L QL EF T I N NN ISD F AV K PNR Y V SYL LS N EM PG SPAQL L RDK G WVSQLT A SPS P SQYG N Y G ALN IS L 360
Cdd:PRK15101 276 G IIIH Y V P AQPR K V L RV EF R I D NN SAK F RS K TDE Y I SYL IG N RS PG TLSDW L QKQ G LAEGIS A GAD P MVDR N S G VFA IS V 355
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 361 E LTD E G MKN R ETI VA T I MQ Y IE L IKKE G V D AK YF N E IRTS L SNQ F KFLEKGDEFS Y VSS L TGS M QDY P LN H AI DAPY YYA 440
Cdd:PRK15101 356 S LTD K G LAQ R DQV VA A I FS Y LN L LREK G I D KS YF D E LAHV L DLD F RYPSITRDMD Y IEW L ADT M LRV P VE H TL DAPY IAD 435
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 441 KF D AE AI NEV L KQLNADTL R V WYIS Q QE ETDSQLH F Y D GK Y RIED IS DAEI A S W KT - SSEFK L A LP SV N NLL P ES F AIKT 519
Cdd:PRK15101 436 RY D PK AI KAR L AEMTPQNA R I WYIS P QE PHNKTAY F V D AP Y QVDK IS EQTF A D W QQ k AQNIA L S LP EL N PYI P DD F SLIK 515
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 520 A E f K EQ KHPEL AY D KN G VK V WRQA SQ K FA AQ PK GLVEVYINTQPGLNDINAE VL YSVWAD L YNIQQS QLS TE A AIA G M S V 599
Cdd:PRK15101 516 A D - K AY KHPEL IV D EP G LR V VYMP SQ Y FA DE PK ADISLVLRNPKAMDSARNQ VL FALNDY L AGLALD QLS NQ A SVG G I S F 594
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 600 NLAPS NGL VLSMS G F T DKQDV LL KQA L S G LKA - DV T AQAFT QA IDR Y KRG L LNQQ K QFP Y A QA FGAYSK L IRTGS F DTEA 678
Cdd:PRK15101 595 STNAN NGL MVNAN G Y T QRLPQ LL QAL L E G YFS f TP T EEQLA QA KSW Y REQ L DSAE K GKA Y E QA IMPAQM L SQVPY F ERDE 674
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 679 LI K AAE S LSVA D LNKLKT A TFATNDLRVFSY GN YNQQDIESI A TELSAT L ps NHTSS E FA R S K AWLPQPGETRVLQ K DID 758
Cdd:PRK15101 675 RR K LLP S ITLK D VLAYRD A LLSGATPEFLVV GN LTEEQVTTL A RDVQKQ L -- GADGT E WW R G K DVVVDKKQSVNFE K AGS 752
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 759 VA D V A VVDMT V h P V p GY KQ --- K A QAAV L QSHFRTIAFDKM RTEEQL A YAV G A LARPIEDYSAI G LFI Q TPV K G P KEIQA 835
Cdd:PRK15101 753 ST D S A LAAVY V - P T - GY DE yqs S A YSSL L GQIIQPWFYNQL RTEEQL G YAV F A FPMSVGRQWGM G FLL Q SND K Q P AYLWQ 830
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 836 R FDQ F KKEYAVE L DN M SLDT FAQ LKN A TLVS L KEQ P KN L SD E MGP L IT D WY R E N FN FDS KQ K L I DEVEKV T LEDIKQYYK 915
Cdd:PRK15101 831 R YQA F FPQAEAK L RA M KPEE FAQ YQQ A LINQ L LQA P QT L GE E ASR L SK D FD R G N MR FDS RD K I I AQIKLL T PQKLADFFH 910
890 900 910 920
....*....|....*....|....*....|....*....|....*...
gi 490726222 916 Q TMLN PQ AARLNV Q LR G TKFVES D F A DLPNQTKIQSLET yyngik LQ K 963
Cdd:PRK15101 911 Q AVIE PQ GLAILS Q IS G SQNGKA D Y A HPKGWKTWENVSA ------ LQ Q 952
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
405-682
4.18e-61
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 209.73
E-value: 4.18e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 405 F K F L EK GDEFS YVSSL TGS MQ D YP LNHAIDAP Y YYAKF D A E A I N E V L KQ L NADTL R VWYI S QQE E -- TD SQLHF Y DGK Y R 482
Cdd:pfam16187 1 F R F Q EK SPPSD YVSSL ASN MQ P YP PEDILSGD Y LLREY D P E L I Q E L L DY L TPENA R ITLV S KEF E ge TD QKEPW Y GTE Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 483 I E D I SDAEIAS WK TSS E F -- K L A LP SV N NLL P ES F AI K TA E F KE - Q K H P E L AY D KNGVKV W RQASQK F a AQ PK GLVEVYI 559
Cdd:pfam16187 81 V E P I PEELLKK WK NAP E P np E L H LP EP N PFI P TD F DL K KK E V KE p A K Y P V L IR D TPLSRL W YKKDDT F - WV PK ANIYLSL 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 560 NTQPGLNDINAE VL YSVWAD L YNIQQSQLSTE A AI AG M S VN L APSN - GL V LS M SG FT DK QD VLL KQA L SG L KA - DVTAQA 637
Cdd:pfam16187 160 RSPLAYSSPRNA VL TRLYVE L LKDSLNEYAYD A EL AG L S YS L SATE r GL T LS V SG YN DK LP VLL EKI L EK L RD f EIDPDR 239
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 490726222 638 F TQAIDRYK R GLL N QQKQF PY A QAF GAYSK L IRTG S FDT E ALIK A 682
Cdd:pfam16187 240 F EIIKEQLL R SYK N FALEQ PY Q QAF DYLLY L LEER S WTP E EKLE A 284
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
43-954
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 963.93
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 43 SPND T R E Y KTL TL E N EIE V I LVSDP S A E KSAA S L S V G VG LLH DP MM QQG M AH Y LEHMLFLGT ER YP DTKG Y SD F MT K N GG 122
Cdd:COG1025 38 SPND P R Q Y RAI TL D N GLK V L LVSDP Q A D KSAA A L A V P VG SFD DP DD QQG L AH F LEHMLFLGT KK YP EPGE Y QE F IS K H GG 117
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 123 VN NA Y T WLDI TNY M F KIN NDA FD EALDRFADFF K AP KLY PEY A D K E K NAVNAE WSMR R EM D FFGQFKLARKMMG - D HP AN 201
Cdd:COG1025 118 SH NA S T ATER TNY Y F EVE NDA LE EALDRFADFF A AP LFD PEY V D R E R NAVNAE YTLK R SD D GRRIYQVHKETLN p A HP FS 197
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 202 RF LI GNLETL G DK E GS Q L HK E TVD FY NK YYS S N I MK VA L I SN LPIEQM E QK A KTY F AD I E N KHIEK P TV T AE L DFDKAG G 281
Cdd:COG1025 198 RF SV GNLETL S DK P GS K L RD E LLA FY QR YYS A N L MK LV L Y SN QSLDEL E KL A RQT F GA I P N RNLSV P PI T VP L YTPEQL G 277
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 282 KKVYYS P NEDVK QL Q LEF T I N NN ISDFAV KP NR Y V SYLL S NE MP GS PAQL L RDK G WVSQ L T A SPSP S q YG N Y G ALN IS LE 361
Cdd:COG1025 278 IIIHIV P LKPRR QL R LEF P I P NN QAYYRS KP LT Y I SYLL G NE GE GS LLDW L KKQ G LAES L S A GGGI S - GR N F G DFS IS VS 356
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 362 LTD E G MKN R ET I V A TIMQ YIELI KKE G VDAK YF N E IRTS L SNQ F K F L EK GDEFS YVS S L TGS M QD YP LNHAI DA P Y YYAK 441
Cdd:COG1025 357 LTD K G LAH R DE I I A AVFA YIELI RQQ G IQEW YF D E QAQL L ELA F R F Q EK TRPMD YVS W L SDN M LR YP VEDVL DA D Y LMDG 436
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 442 FD AE AI NEV L K QL NADTL R V W Y IS QQEE TD SQLHF YD GK Y RIED I SDAEI A S W - KT S SEFK L A LP SV N NLL P ES F AIKTA 520
Cdd:COG1025 437 FD PA AI RAR L A QL TPENA R I W L IS PDVP TD KTAYW YD TP Y SVDP I TQEQL A K W q QA S QNPA L S LP EL N PYI P DD F SLIKL 516
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 521 E f KE QKH PEL AY D KN G VKV W RQAS Q K F a A Q PK GLVEVYINTQPGLNDINAE VL YSVWAD L Y N IQQSQ LS TE A AI AG M S VN 600
Cdd:COG1025 517 D - KE SAK PEL LV D EP G LRL W YMPD Q Y F - A E PK ADIYLSLRNPQAVDSARNQ VL TRLLDY L L N DALNE LS YQ A SV AG L S YS 594
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 601 L APS - N GL V LS M SGFT D KQ DV LL KQA L SG L KA - DV T AQA F T QA IDRYK R G L L N QQ K QF PY A Q A F GAY S K L IRTGS F DT E A 678
Cdd:COG1025 595 L YAH q G GL T LS A SGFT Q KQ PK LL EAL L DQ L AS f EP T EER F A QA KSQLL R Q L D N AE K AK PY S Q L F SPL S R L LQPPY F ER E E 674
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 679 L IK A A ES LSVA DL NKLKTATFATND L RVFSY GN YNQQDIESI A TE L SAT L PS N H T s S E FA R SKAWLPQPGETRV L Q K DI D 758
Cdd:COG1025 675 L LA A L ES ITLQ DL RAFREQLLQQLH L EMLVV GN LSEEQAKQL A DS L KKQ L AP N G T - G E EP R RQVVDLDKSGSLN L E K AC D 753
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 759 VA D V A VVDMTVHPVPGYKQK A QAAV L QSHFRTIA F DKM RTEEQL A Y A VGA LAR P IEDYSAI G LFI Q T PV KG P KEIQA R F D 838
Cdd:COG1025 754 HT D S A LLIYYQSGYDSLASM A LSSL L GQIISPWF F NQL RTEEQL G Y V VGA GYM P LGRQPGL G FYV Q S PV AS P AYLLE R I D 833
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 839 Q F K K EYAVE L DNM S LDT FAQ L K NATLVS L K E QPK NLS D E MGP L IT D WYREN F N FD SKQ KLI DE V E K V T LE D IKQYYK Q TM 918
Cdd:COG1025 834 D F L K QFEER L LAL S EEE FAQ Y K QGLINQ L L E PDQ NLS E E AQR L WV D IGNGD F E FD TRE KLI AA V K K L T RA D LIDFFQ Q AV 913
890 900 910
....*....|....*....|....*....|....*.
gi 490726222 919 LN PQ AA RL NV Q LR GTK F ve S DFAD L PNQTK I QSLET 954
Cdd:COG1025 914 IA PQ GL RL LS Q SQ GTK H -- S KADE L KGWKT I TDISA 947
PRK15101
PRK15101 protease3; Provisional
43-963
0e+00
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 636.63
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 43 S PN D T R E Y KTLT L E N EIE V I LVSDP S A E KS A A S L SVG VG L L H DP MM QQG M AHYLEHM LFL G TER YP DTKGYSD F MT K N GG 122
Cdd:PRK15101 37 S EK D P R Q Y QAIR L D N GMT V L LVSDP Q A V KS L A A L ALP VG S L E DP DA QQG L AHYLEHM VLM G SKK YP QPDSLAE F LK K H GG 116
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 123 VN NA Y T WLDI T NYMFKIN NDA FDE A L DR F AD FFKA P K L Y P EY AD K E K NAVNAE WS M R R EM D -- FFG Q FKLA r KMMGD HP A 200
Cdd:PRK15101 117 SH NA S T ASYR T AFYLEVE NDA LPP A V DR L AD AIAE P L L D P KN AD R E R NAVNAE LT M A R SR D gm RMA Q VSAE - TINPA HP G 195
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 201 N RF LI GNLETL G DK E GS Q L HKET VDFY NK YYS S N I MK VALI SN L P IEQMEQK A KTY F ADIE NK HIEK P TV T AELDF D KAG 280
Cdd:PRK15101 196 S RF SG GNLETL S DK P GS K L QDAL VDFY QR YYS A N L MK AVIY SN Q P LPELAKL A ADT F GRVP NK NASV P EI T VPVVT D AQK 275
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 281 G KKVY Y S P NEDV K Q L QL EF T I N NN ISD F AV K PNR Y V SYL LS N EM PG SPAQL L RDK G WVSQLT A SPS P SQYG N Y G ALN IS L 360
Cdd:PRK15101 276 G IIIH Y V P AQPR K V L RV EF R I D NN SAK F RS K TDE Y I SYL IG N RS PG TLSDW L QKQ G LAEGIS A GAD P MVDR N S G VFA IS V 355
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 361 E LTD E G MKN R ETI VA T I MQ Y IE L IKKE G V D AK YF N E IRTS L SNQ F KFLEKGDEFS Y VSS L TGS M QDY P LN H AI DAPY YYA 440
Cdd:PRK15101 356 S LTD K G LAQ R DQV VA A I FS Y LN L LREK G I D KS YF D E LAHV L DLD F RYPSITRDMD Y IEW L ADT M LRV P VE H TL DAPY IAD 435
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 441 KF D AE AI NEV L KQLNADTL R V WYIS Q QE ETDSQLH F Y D GK Y RIED IS DAEI A S W KT - SSEFK L A LP SV N NLL P ES F AIKT 519
Cdd:PRK15101 436 RY D PK AI KAR L AEMTPQNA R I WYIS P QE PHNKTAY F V D AP Y QVDK IS EQTF A D W QQ k AQNIA L S LP EL N PYI P DD F SLIK 515
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 520 A E f K EQ KHPEL AY D KN G VK V WRQA SQ K FA AQ PK GLVEVYINTQPGLNDINAE VL YSVWAD L YNIQQS QLS TE A AIA G M S V 599
Cdd:PRK15101 516 A D - K AY KHPEL IV D EP G LR V VYMP SQ Y FA DE PK ADISLVLRNPKAMDSARNQ VL FALNDY L AGLALD QLS NQ A SVG G I S F 594
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 600 NLAPS NGL VLSMS G F T DKQDV LL KQA L S G LKA - DV T AQAFT QA IDR Y KRG L LNQQ K QFP Y A QA FGAYSK L IRTGS F DTEA 678
Cdd:PRK15101 595 STNAN NGL MVNAN G Y T QRLPQ LL QAL L E G YFS f TP T EEQLA QA KSW Y REQ L DSAE K GKA Y E QA IMPAQM L SQVPY F ERDE 674
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 679 LI K AAE S LSVA D LNKLKT A TFATNDLRVFSY GN YNQQDIESI A TELSAT L ps NHTSS E FA R S K AWLPQPGETRVLQ K DID 758
Cdd:PRK15101 675 RR K LLP S ITLK D VLAYRD A LLSGATPEFLVV GN LTEEQVTTL A RDVQKQ L -- GADGT E WW R G K DVVVDKKQSVNFE K AGS 752
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 759 VA D V A VVDMT V h P V p GY KQ --- K A QAAV L QSHFRTIAFDKM RTEEQL A YAV G A LARPIEDYSAI G LFI Q TPV K G P KEIQA 835
Cdd:PRK15101 753 ST D S A LAAVY V - P T - GY DE yqs S A YSSL L GQIIQPWFYNQL RTEEQL G YAV F A FPMSVGRQWGM G FLL Q SND K Q P AYLWQ 830
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 836 R FDQ F KKEYAVE L DN M SLDT FAQ LKN A TLVS L KEQ P KN L SD E MGP L IT D WY R E N FN FDS KQ K L I DEVEKV T LEDIKQYYK 915
Cdd:PRK15101 831 R YQA F FPQAEAK L RA M KPEE FAQ YQQ A LINQ L LQA P QT L GE E ASR L SK D FD R G N MR FDS RD K I I AQIKLL T PQKLADFFH 910
890 900 910 920
....*....|....*....|....*....|....*....|....*...
gi 490726222 916 Q TMLN PQ AARLNV Q LR G TKFVES D F A DLPNQTKIQSLET yyngik LQ K 963
Cdd:PRK15101 911 Q AVIE PQ GLAILS Q IS G SQNGKA D Y A HPKGWKTWENVSA ------ LQ Q 952
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
405-682
4.18e-61
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 209.73
E-value: 4.18e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 405 F K F L EK GDEFS YVSSL TGS MQ D YP LNHAIDAP Y YYAKF D A E A I N E V L KQ L NADTL R VWYI S QQE E -- TD SQLHF Y DGK Y R 482
Cdd:pfam16187 1 F R F Q EK SPPSD YVSSL ASN MQ P YP PEDILSGD Y LLREY D P E L I Q E L L DY L TPENA R ITLV S KEF E ge TD QKEPW Y GTE Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 483 I E D I SDAEIAS WK TSS E F -- K L A LP SV N NLL P ES F AI K TA E F KE - Q K H P E L AY D KNGVKV W RQASQK F a AQ PK GLVEVYI 559
Cdd:pfam16187 81 V E P I PEELLKK WK NAP E P np E L H LP EP N PFI P TD F DL K KK E V KE p A K Y P V L IR D TPLSRL W YKKDDT F - WV PK ANIYLSL 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 560 NTQPGLNDINAE VL YSVWAD L YNIQQSQLSTE A AI AG M S VN L APSN - GL V LS M SG FT DK QD VLL KQA L SG L KA - DVTAQA 637
Cdd:pfam16187 160 RSPLAYSSPRNA VL TRLYVE L LKDSLNEYAYD A EL AG L S YS L SATE r GL T LS V SG YN DK LP VLL EKI L EK L RD f EIDPDR 239
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 490726222 638 F TQAIDRYK R GLL N QQKQF PY A QAF GAYSK L IRTG S FDT E ALIK A 682
Cdd:pfam16187 240 F EIIKEQLL R SYK N FALEQ PY Q QAF DYLLY L LEER S WTP E EKLE A 284
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
49-471
1.97e-51
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 187.05
E-value: 1.97e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 49 EYKTL TL E N EIE VILV S DP S A EKSAAS L S V G VG LLHD P MMQQ G M AH Y LEHMLF L GT ERYP d TKGYSDFMTKN GG VN NA Y T 128
Cdd:COG0612 14 DVEEF TL P N GLR VILV P DP E A PVVSVR L W V R VG SRDE P PGKT G L AH F LEHMLF K GT KKRS - AGEIAEELEAL GG SL NA F T 92
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 129 WL D I T N Y MFKINNDAFDE AL DRF AD FFKA P KLYP E YADK E KNA V NA E WSMRREM - D FFGQFK L ARKMM GDHP AN R FL IG N 207
Cdd:COG0612 93 SF D Y T V Y YLSVLSEDLEL AL ELL AD RLLN P TFDE E ELER E RGV V LE E IRRYEDD p D GLAFEA L LAALY GDHP YG R PI IG T 172
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 208 L E TL gdkeg SQLHK E TV - D FY NK YY SS N IMKVALISNLPI E QMEQKAKT YF A D IENKHIEKPTVT AE LDFDKAGGKK V YY 286
Cdd:COG0612 173 E E SI ----- EAITR E DL r A FY KR YY RP N NAVLVVVGDVDP E EVLALVEK YF G D LPAGPAPPRPDP AE PPQTGPRRVV V DD 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 287 spn E D VK Q -- LQ L EFTINN nisdf AVK P NR Y VSYL L SN --- EMPG S P - A Q L LR - D KG WVSQLTA S P SP SQY gn Y G ALN I S 359
Cdd:COG0612 248 --- P D AE Q ah IL L GYPGPA ----- RDD P DY Y ALDV L NE ilg GGFS S R l F Q E LR e K KG LAYSVGS S F SP YRD -- A G LFT I Y 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 360 LELTDE gmk NR E TIV A T I MQYI E LIK KEGV DAKYFNEIRTS L SNQFKF le KGDEF S YVS S LT G SMQD Y -- P L NHAIDAPY 437
Cdd:COG0612 318 AGTAPD --- KL E EAL A A I LEEL E RLA KEGV TEEELERAKNQ L LGSLAL -- SLESN S GLA S QL G RYEL Y gg D L DYLEEYLE 392
410 420 430
....*....|....*....|....*....|....
gi 490726222 438 YYAKFD AE AINE V LKQLNADTLR V WYISQQEETD 471
Cdd:COG0612 393 RIEAVT AE DVQA V ARKYLDPDNL V VVVVGPKKKA 426
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
61-197
1.22e-28
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 112.01
E-value: 1.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 61 V ILV SDP S A EK S AAS L SVGV G LLHD P MMQQ G M AH Y LEHM L F L GT ER YP DTK g YSDFMT K N GG VN NA Y T WLDI T N Y MFKIN 140
Cdd:pfam00675 2 V ASE SDP P A DT S TVG L WIDA G SRYE P DNNN G L AH F LEHM A F K GT KK YP SNE - LEEELE K L GG SL NA F T SREN T V Y YAEVL 80
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490726222 141 ND AFDE A L DR F ADFF KA P KLYPEYADK E K ------- N AV NA E WSMRREM ---- DFFGQFK L A R KMM G D 197
Cdd:pfam00675 81 ND DLPK A V DR L ADFF RN P LFTESEIER E R lvvlyev E AV DS E PQLVVLE nlha AAYRNTP L G R SLL G P 148
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
225-401
5.07e-21
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 91.30
E-value: 5.07e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 225 DFY N K Y YS SNI M KVALISNLPI E QMEQK A KT YF A D IENKHIE KP TVTAELDFDKA G GKK V YYSPN E DVKQ L Q L E F TINNN 304
Cdd:pfam05193 9 DFY K K H YS PDN M VLVIVGDVDH E ELLDL A EK YF G D LPASPKG KP RPPPLEPAKLK G REV V VPKKD E PQAH L A L A F PGPPL 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 305 IS D FAVKPNRYVSY LL SNE M PGSPA Q L LR D K - G WVSQLTA sp SPSQ Y GNY G ALN I SLELTD E gmk N RETIVAT I MQYI E L 383
Cdd:pfam05193 89 NN D EDSLALDVLNE LL GGG M SSRLF Q E LR E K e G LAYSVSS -- FNDS Y SDS G LFG I YATVDP E --- N VDEVIEL I LEEL E K 163
170
....*....|....*...
gi 490726222 384 IKK EGV DAKYFNEIRTS L 401
Cdd:pfam05193 164 LAQ EGV TEEELERAKNQ L 181
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
637-923
4.39e-11
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 66.10
E-value: 4.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 637 A F TQA - ID R YKRGL L N --- QQKQF P YAQ AF G A YSKLI ------- R TGSFDT E AL ikaa E SLSVA DL NKLKTATFAT N DLR 705
Cdd:COG0612 123 T F DEE e LE R ERGVV L E eir RYEDD P DGL AF E A LLAAL ygdhpyg R PIIGTE E SI ---- E AITRE DL RAFYKRYYRP N NAV 198
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 706 VFSY G NYNQQDIESIATELSAT LP SNHTSSEFARSKAWLPQ P GETR V LQK D IDV A DVAVV dmtv H P V P GYKQKAQA A --- 782
Cdd:COG0612 199 LVVV G DVDPEEVLALVEKYFGD LP AGPAPPRPDPAEPPQTG P RRVV V DDP D AEQ A HILLG ---- Y P G P ARDDPDYY A ldv 274
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 783 --- V L QSH F RTIA F DKM R TEEQ LAY A VG ALAR P IE D YSAIGLFIQ T PVKGPK E IQ A RFDQ fkkeyav EL DNMSLDTF --- 856
Cdd:COG0612 275 lne I L GGG F SSRL F QEL R EKKG LAY S VG SSFS P YR D AGLFTIYAG T APDKLE E AL A AILE ------- EL ERLAKEGV tee 347
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490726222 857 ------ A QL KNATLV SL k E QPKN L SDEM G plit DWYRENFNF D SKQKLIDEV E K VT L ED IKQYYKQ t M L N P QA 923
Cdd:COG0612 348 elerak N QL LGSLAL SL - E SNSG L ASQL G ---- RYELYGGDL D YLEEYLERI E A VT A ED VQAVARK - Y L D P DN 414
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
685-842
2.67e-04
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 42.77
E-value: 2.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 685 SL SVA DL NKLKTATFATNDLRVFSY G NYNQQDIESI A TELSAT LP SNHTSSEFARSKAWLPQP G ETR V L - Q KD IDV A DV A 763
Cdd:pfam05193 1 SL TRE DL RDFYKKHYSPDNMVLVIV G DVDHEELLDL A EKYFGD LP ASPKGKPRPPPLEPAKLK G REV V V p K KD EPQ A HL A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726222 764 VV d MTVH P VPGYKQKAQAA VL QSHF ---- RTIA F DKM R TE E Q LAY A V GALARPIE D YSAI G LFIQT - P VKGPKE I QARFD 838
Cdd:pfam05193 81 LA - FPGP P LNNDEDSLALD VL NELL gggm SSRL F QEL R EK E G LAY S V SSFNDSYS D SGLF G IYATV d P ENVDEV I ELILE 159
....
gi 490726222 839 QFK K 842
Cdd:pfam05193 160 ELE K 163
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
