|
Name |
Accession |
Description |
Interval |
E-value |
| PRK13960 |
PRK13960 |
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional |
1-366 |
0e+00 |
|
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
Pssm-ID: 184420 Cd Length: 367 Bit Score: 686.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 1 MTSYKVLDVNDDLPIRTKGAVHSGKVRSVYWLTDEDSARLIKEKNYKVPQGTELAIMVISDRISAFDCIWQGENGLNGVP 80
Cdd:PRK13960 2 SLADKVLAVNDDLPIRTDKPVHSGKVRSVYWLTEEDSRRLIKEKGYNVPADAPLAIMVISDRISAFDCIWHGEGGLNGVP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 81 GKGIALNSVASHWFKLFDKAGLAGNHIVDIPHPYVWIVRKASTVKVEAIARQYITGSMWRDYSKGVRNFCGIDLPEGLRA 160
Cdd:PRK13960 82 GKGAALNAISNHWFKLFKENGLADSHILDIPHPFVWIVQKARPVMIEAICRQYITGSMWRAYSKGEREFCGITLPEGLEK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 161 NQKLENVLITPSTKGIIEGVADIPPVDDVNITRANITDNLDVFNFKSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTK 240
Cdd:PRK13960 162 DQKLPELLITPSTKGILTGIPGVPEADDVNISRSDIEANYQAFNFSSADDIDLYEKLLKEGFKVISDALAKLDQIFVDTK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 241 FEFGYVEDLDGNQQLIYIDEVGTPDSSRIWDGAAYRDGKIIENSKEGFRQLLISTVPESDVLLNKDRMDEREQLAKDFIL 320
Cdd:PRK13960 242 FEFGYVTDAAGNEKLIYMDEVGTPDSSRIWDGAAYRDGKIVENSKEGFRQFLLNHFPDPDILLNKDRMPEREALARDNAL 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 490726577 321 PESVMLEVSNTYVGIASKIIGKEIVIPEDPRQEVINILDTDYDLIV 366
Cdd:PRK13960 322 PLEAMMDVSRTYTGIAEKITGAKIVLSANPKAEIIDILREEYGLID 367
|
|
| purC_vibrio |
TIGR02735 |
phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio type; Members of this protein ... |
5-365 |
0e+00 |
|
phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio type; Members of this protein family appear to represent a novel form of phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase), significantly different in sequence and gap pattern from a form (see TIGR00081) shared by a broad range of bacteria and eukaryotes. Members of this family are found within the gammaproteobacteria in the genera Vibrio, Shewanella, and Colwellia, and also (reported as a fragment) in the primitive eukarote Guillardia theta. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 131782 Cd Length: 365 Bit Score: 577.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 5 KVLDVNDDLPIRTKGAVHSGKVRSVYWLTDEDSARLIKEKNYKVPQGTELAIMVISDRISAFDCIWQGENGLNGVPGKGI 84
Cdd:TIGR02735 5 QVLAVNDDLPIRTDEPVHSGKVRSVYWLTEEDSRRLIEEKGYPVAHDAPLAIMVISDRISAFDCIWHAEGGLNGVPGKGA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 85 ALNSVASHWFKLFDKAGLAGNHIVDIPHPYVWIVRKASTVKVEAIARQYITGSMWRDYSKGVRNFCGIDLPEGLRANQKL 164
Cdd:TIGR02735 85 ALNAISNHWFKLFAEAGLAESHILDIPHPFVWIVQKAKPVKIEAICRQYITGSMWRAYAKGERVFCGIDLPEGLAKDQRL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 165 ENVLITPSTKGIIEGVADIPPVDDVNITRANITDNLDVFNFKSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFG 244
Cdd:TIGR02735 165 PELLITPSTKGILEGIPGVPAIDDVNITRADIERNWSAFNFEQPEDIDHYERLLREGFAVISDRLSKLGQLFVDTKFEFG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 245 YVEDLDGNQQLIYIDEVGTPDSSRIWDGAAYRDGKIIENSKEGFRQLLISTVPESDVLLNKDRMDEREQLAKDFILPESV 324
Cdd:TIGR02735 245 YVTDVEGTRKLIYMDEVGTPDSSRIWDAGAYAQGKIVENSKEGFRQALLNWFPDPDILLNKDRMVERAALARDNALPQEM 324
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 490726577 325 MLEVSNTYVGIASKIIGKEIVIPEDPRQEVINILDTDYDLI 365
Cdd:TIGR02735 325 LMDVSETYLGIAEKITGSSITLSENPKAEIKAILSVEYGLV 365
|
|
| SAICAR_synt_Sc |
cd01414 |
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ... |
21-341 |
7.99e-86 |
|
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.
Pssm-ID: 133469 [Multi-domain] Cd Length: 279 Bit Score: 260.94 E-value: 7.99e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 21 VHSGKVRSVYWLTDEDsarlikeknykvpqgtelAIMVISDRISAFDCIWQgenglNGVPGKGIALNSVASHWFKLFdkA 100
Cdd:cd01414 2 IYSGKVRDVYDLGDGR------------------LLFVATDRISAFDVILP-----PDIPGKGEVLTQISAFWFELT--E 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 101 GLAGNHIVDI-------------PHPYVWIVRKASTVKVEAIARQYITGSMWRDYSKGVRNfCGIDLPEGLRANQKLENV 167
Cdd:cd01414 57 DIIPNHLISTdvedlpeikepedPDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYQKGGTV-CGIKLPEGLREAQKLPEP 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 168 LITPSTKGIIEgvadippvDDVNITRANITDNLdvfnfkSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFGYve 247
Cdd:cd01414 136 IFTPSTKAEEG--------HDENISFEEAVEII------GAELADELRELALALYERAAEYAAKRGLILADTKFEFGL-- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 248 dlDGNQQLIYIDEVGTPDSSRIWDGAAYRDGKIIEN-SKEGFRQLLISTVPesdvllnkdrmDEREQLAKDfiLPESVML 326
Cdd:cd01414 200 --DENGEIILIDEVLTPDSSRFWPADSYEPGKEQPSfDKQFVRDWLEASGW-----------DKQDPPPPP--LPAEVIE 264
|
330
....*....|....*
gi 490726577 327 EVSNTYVGIASKIIG 341
Cdd:cd01414 265 KTSARYIEAYERITG 279
|
|
| PurC |
COG0152 |
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ... |
13-296 |
7.90e-67 |
|
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439922 Cd Length: 245 Bit Score: 211.09 E-value: 7.90e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 13 LPIRTKgaVHSGKVRSVYWlTDEDsarlikeknykvpqgteLAIMVISDRISAFDCIWQGEnglngVPGKGIALNSVASH 92
Cdd:COG0152 1 MPKLEL--LYEGKVKDVYA-TDDD-----------------TLLMVFKDRISAFDGVKPDP-----IPGKGEVLNQISAF 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 93 WFKLFDKAGLAgNHIVDIPHPYVWIVRKASTVKVEAIARQYITGSMWRDYSKgvrnfcGIDLPEGLRANQKLENVLITPS 172
Cdd:COG0152 56 WFELLEDIGIP-THFIETLSGREMLVKKLEMIPVEVVVRNYAAGSLWKRYQA------GIALPLGLEEGTKLPEPIFEPS 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 173 TKgiiegvADIppVDDVNITRANITDnldvFNFKSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFGyvedLDGN 252
Cdd:COG0152 129 TK------ADE--GHDPNISEEHIVA----LGLATEEEAEELRELALKINERLSELAAERGIILVDTKLEFG----RDAD 192
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 490726577 253 QQLIYIDEVgTPDSSRIWDGAAYRdgkiiENSKEGFRQLLISTV 296
Cdd:COG0152 193 GEIVLADEI-TPDSSRLWDADTYE-----SLDKDRFRDWLGGNT 230
|
|
| SAICAR_synt |
pfam01259 |
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase. |
21-276 |
1.25e-42 |
|
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
Pssm-ID: 460140 Cd Length: 228 Bit Score: 147.89 E-value: 1.25e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 21 VHSGKVRSVYWLTDEDsarlikeknykvpqgteLAIMVISDRISAFDCIWQgenglNGVPGKGIALNSVASHWFKLFDKA 100
Cdd:pfam01259 2 LYEGKVKDVYETDDPD-----------------TLLVVAKDRISAFDGVKK-----GTIPGKGAVNNQISAFWFELLEIA 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 101 GLAgNHIVDIPHPYVWIVRKASTVKVEAIARQYITGSMwrdyskGVRnfcgidLPeGLRANQKLENVLITPSTKgiiegv 180
Cdd:pfam01259 60 GIP-THFIKSLSGREMLVKKVKIIPLEVVVRNYAAGSL------GKR------LP-GLKEGTKLPEPIFEPSTK------ 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 181 ADIppVDDVNITRANITdnldVFNFKSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFGyvedLDGNQQLIYIDE 260
Cdd:pfam01259 120 ADA--LGDPNINEEHIV----ALGLATEEEAEEIRELALKINEILKEYAAERGIILVDTKLEFG----LDSDGEIVLADE 189
|
250
....*....|....*.
gi 490726577 261 VgTPDSSRIWDGAAYR 276
Cdd:pfam01259 190 I-TPDSSRFWDADTYE 204
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK13960 |
PRK13960 |
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional |
1-366 |
0e+00 |
|
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
Pssm-ID: 184420 Cd Length: 367 Bit Score: 686.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 1 MTSYKVLDVNDDLPIRTKGAVHSGKVRSVYWLTDEDSARLIKEKNYKVPQGTELAIMVISDRISAFDCIWQGENGLNGVP 80
Cdd:PRK13960 2 SLADKVLAVNDDLPIRTDKPVHSGKVRSVYWLTEEDSRRLIKEKGYNVPADAPLAIMVISDRISAFDCIWHGEGGLNGVP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 81 GKGIALNSVASHWFKLFDKAGLAGNHIVDIPHPYVWIVRKASTVKVEAIARQYITGSMWRDYSKGVRNFCGIDLPEGLRA 160
Cdd:PRK13960 82 GKGAALNAISNHWFKLFKENGLADSHILDIPHPFVWIVQKARPVMIEAICRQYITGSMWRAYSKGEREFCGITLPEGLEK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 161 NQKLENVLITPSTKGIIEGVADIPPVDDVNITRANITDNLDVFNFKSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTK 240
Cdd:PRK13960 162 DQKLPELLITPSTKGILTGIPGVPEADDVNISRSDIEANYQAFNFSSADDIDLYEKLLKEGFKVISDALAKLDQIFVDTK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 241 FEFGYVEDLDGNQQLIYIDEVGTPDSSRIWDGAAYRDGKIIENSKEGFRQLLISTVPESDVLLNKDRMDEREQLAKDFIL 320
Cdd:PRK13960 242 FEFGYVTDAAGNEKLIYMDEVGTPDSSRIWDGAAYRDGKIVENSKEGFRQFLLNHFPDPDILLNKDRMPEREALARDNAL 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 490726577 321 PESVMLEVSNTYVGIASKIIGKEIVIPEDPRQEVINILDTDYDLIV 366
Cdd:PRK13960 322 PLEAMMDVSRTYTGIAEKITGAKIVLSANPKAEIIDILREEYGLID 367
|
|
| purC_vibrio |
TIGR02735 |
phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio type; Members of this protein ... |
5-365 |
0e+00 |
|
phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio type; Members of this protein family appear to represent a novel form of phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase), significantly different in sequence and gap pattern from a form (see TIGR00081) shared by a broad range of bacteria and eukaryotes. Members of this family are found within the gammaproteobacteria in the genera Vibrio, Shewanella, and Colwellia, and also (reported as a fragment) in the primitive eukarote Guillardia theta. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 131782 Cd Length: 365 Bit Score: 577.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 5 KVLDVNDDLPIRTKGAVHSGKVRSVYWLTDEDSARLIKEKNYKVPQGTELAIMVISDRISAFDCIWQGENGLNGVPGKGI 84
Cdd:TIGR02735 5 QVLAVNDDLPIRTDEPVHSGKVRSVYWLTEEDSRRLIEEKGYPVAHDAPLAIMVISDRISAFDCIWHAEGGLNGVPGKGA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 85 ALNSVASHWFKLFDKAGLAGNHIVDIPHPYVWIVRKASTVKVEAIARQYITGSMWRDYSKGVRNFCGIDLPEGLRANQKL 164
Cdd:TIGR02735 85 ALNAISNHWFKLFAEAGLAESHILDIPHPFVWIVQKAKPVKIEAICRQYITGSMWRAYAKGERVFCGIDLPEGLAKDQRL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 165 ENVLITPSTKGIIEGVADIPPVDDVNITRANITDNLDVFNFKSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFG 244
Cdd:TIGR02735 165 PELLITPSTKGILEGIPGVPAIDDVNITRADIERNWSAFNFEQPEDIDHYERLLREGFAVISDRLSKLGQLFVDTKFEFG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 245 YVEDLDGNQQLIYIDEVGTPDSSRIWDGAAYRDGKIIENSKEGFRQLLISTVPESDVLLNKDRMDEREQLAKDFILPESV 324
Cdd:TIGR02735 245 YVTDVEGTRKLIYMDEVGTPDSSRIWDAGAYAQGKIVENSKEGFRQALLNWFPDPDILLNKDRMVERAALARDNALPQEM 324
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 490726577 325 MLEVSNTYVGIASKIIGKEIVIPEDPRQEVINILDTDYDLI 365
Cdd:TIGR02735 325 LMDVSETYLGIAEKITGSSITLSENPKAEIKAILSVEYGLV 365
|
|
| SAICAR_synt_Sc |
cd01414 |
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ... |
21-341 |
7.99e-86 |
|
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.
Pssm-ID: 133469 [Multi-domain] Cd Length: 279 Bit Score: 260.94 E-value: 7.99e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 21 VHSGKVRSVYWLTDEDsarlikeknykvpqgtelAIMVISDRISAFDCIWQgenglNGVPGKGIALNSVASHWFKLFdkA 100
Cdd:cd01414 2 IYSGKVRDVYDLGDGR------------------LLFVATDRISAFDVILP-----PDIPGKGEVLTQISAFWFELT--E 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 101 GLAGNHIVDI-------------PHPYVWIVRKASTVKVEAIARQYITGSMWRDYSKGVRNfCGIDLPEGLRANQKLENV 167
Cdd:cd01414 57 DIIPNHLISTdvedlpeikepedPDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYQKGGTV-CGIKLPEGLREAQKLPEP 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 168 LITPSTKGIIEgvadippvDDVNITRANITDNLdvfnfkSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFGYve 247
Cdd:cd01414 136 IFTPSTKAEEG--------HDENISFEEAVEII------GAELADELRELALALYERAAEYAAKRGLILADTKFEFGL-- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 248 dlDGNQQLIYIDEVGTPDSSRIWDGAAYRDGKIIEN-SKEGFRQLLISTVPesdvllnkdrmDEREQLAKDfiLPESVML 326
Cdd:cd01414 200 --DENGEIILIDEVLTPDSSRFWPADSYEPGKEQPSfDKQFVRDWLEASGW-----------DKQDPPPPP--LPAEVIE 264
|
330
....*....|....*
gi 490726577 327 EVSNTYVGIASKIIG 341
Cdd:cd01414 265 KTSARYIEAYERITG 279
|
|
| PurC |
COG0152 |
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ... |
13-296 |
7.90e-67 |
|
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439922 Cd Length: 245 Bit Score: 211.09 E-value: 7.90e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 13 LPIRTKgaVHSGKVRSVYWlTDEDsarlikeknykvpqgteLAIMVISDRISAFDCIWQGEnglngVPGKGIALNSVASH 92
Cdd:COG0152 1 MPKLEL--LYEGKVKDVYA-TDDD-----------------TLLMVFKDRISAFDGVKPDP-----IPGKGEVLNQISAF 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 93 WFKLFDKAGLAgNHIVDIPHPYVWIVRKASTVKVEAIARQYITGSMWRDYSKgvrnfcGIDLPEGLRANQKLENVLITPS 172
Cdd:COG0152 56 WFELLEDIGIP-THFIETLSGREMLVKKLEMIPVEVVVRNYAAGSLWKRYQA------GIALPLGLEEGTKLPEPIFEPS 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 173 TKgiiegvADIppVDDVNITRANITDnldvFNFKSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFGyvedLDGN 252
Cdd:COG0152 129 TK------ADE--GHDPNISEEHIVA----LGLATEEEAEELRELALKINERLSELAAERGIILVDTKLEFG----RDAD 192
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 490726577 253 QQLIYIDEVgTPDSSRIWDGAAYRdgkiiENSKEGFRQLLISTV 296
Cdd:COG0152 193 GEIVLADEI-TPDSSRLWDADTYE-----SLDKDRFRDWLGGNT 230
|
|
| PRK12607 |
PRK12607 |
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional |
19-350 |
3.60e-57 |
|
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
Pssm-ID: 183621 [Multi-domain] Cd Length: 313 Bit Score: 188.56 E-value: 3.60e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 19 GAVHSGKVRSVYWLTDEdsarlikeknykvpqgteLAIMVISDRISAFDCIwqgengLNGVPGKGIALNSVASHWFKLfd 98
Cdd:PRK12607 16 PNVYRGKVRDNYDLPDG------------------RRVMVATDRISAFDRV------LPAIPYKGQVLNQTAAFWFEA-- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 99 KAGLAGNHIVDIPHPYVWIVRKASTVKVEAIARQYITGSMWRDYSKGVRNFCGIDLPEGLRANQKLENVLITPSTKGIIE 178
Cdd:PRK12607 70 TKDICPNHVLAVPDPNVVVGKRCEPFPVEMVVRGYLAGSTWRLYKAGKREMYGVTLPDGLRENQKLPEPIITPTTKAEEG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 179 GvadippvDDVNITRANITDNldvfNFKSAED---VTKYEKLLvegFKLISEELAKLDQIFVDTKFEFGyvEDLDGNqqL 255
Cdd:PRK12607 150 G-------HDEPISPEEILAQ----GLLTPEDwdeLSKYALAL---FARGQEMAAERGLILVDTKYEFG--KDADGR--I 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 256 IYIDEVGTPDSSRIW--DG--AAYRDGKIIEN-SKEGFRQLLIS-------TVPEsdvllnkdrmdereqlakdfiLPES 323
Cdd:PRK12607 212 VLIDEIHTPDSSRYWyaDGyeERFAAGEPQEQlDKEFVRQWLIErcgpygqEIPE---------------------IPDE 270
|
330 340
....*....|....*....|....*..
gi 490726577 324 VMLEVSNTYVGIASKIIGKEIVIPEDP 350
Cdd:PRK12607 271 VIVSVSERYIELYEKITGETFVPDSGS 297
|
|
| PLN02544 |
PLN02544 |
phosphoribosylaminoimidazole-succinocarboxamide synthase |
24-356 |
1.34e-49 |
|
phosphoribosylaminoimidazole-succinocarboxamide synthase
Pssm-ID: 178159 [Multi-domain] Cd Length: 370 Bit Score: 170.39 E-value: 1.34e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 24 GKVRSVYwltdedsarlikeknykvpQGTELAIMVISDRISAFDCIwqgengLNGVPGKGIALNSVASHWFKlfDKAGLA 103
Cdd:PLN02544 81 GKVRDIY-------------------DLGDYLVLVTTDRQSAFDRV------LASIPFKGQVLNQTSAWWFN--NTKHIT 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 104 GNHIVDIPHPYVWIVRKASTVKVEAIARQYITGS----MWRDYSKGVRNFCGIDLPEGLRANQKLENVLITPSTKGiieg 179
Cdd:PLN02544 134 PNALVSSPDPNVTIAKKCSVFPVEFVVRGYMTGStstsLWTVYNKGVRNYCGNDLPDGMVKNQKLPANILTPTTKA---- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 180 vADippvDDVNITRANITDNldvfNFKSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFGyvEDLDGNQQLiyID 259
Cdd:PLN02544 210 -AD----HDVPISPEEIVEE----GLMTQEDFDEVSSKALALFAFGQEVAAEHGLILVDTKYEFG--KDADGTILL--ID 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 260 EVGTPDSSRIWDGAAY----RDGKIIEN-SKEGFRqllistvpesdvLLNKDRMDEReqlaKDFILPES---VMLEVSNT 331
Cdd:PLN02544 277 EVHTPDSSRYWLADSYeerhAAGLEPENiDKEFLR------------LWFKENCDPY----KDEVLPEApaeLVCELSWR 340
|
330 340
....*....|....*....|....*
gi 490726577 332 YVGIASKIIGKEIVIPedPRQEVIN 356
Cdd:PLN02544 341 YIKLYETITGEKFEVP--DTQEPIH 363
|
|
| PRK13961 |
PRK13961 |
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional |
21-279 |
6.49e-44 |
|
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
Pssm-ID: 237571 Cd Length: 296 Bit Score: 153.43 E-value: 6.49e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 21 VHSGKVRSVYWLTDEdsaRLIkeknykvpqgtelaiMVISDRISAFDCIWQgenglNGVPGKGIALNSVASHWFKLFdkA 100
Cdd:PRK13961 15 LGRGKVRDIYAVDDD---RLL---------------MVATDRISAFDVILP-----EPIPDKGRVLTQMSNFWFDKL--A 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 101 GLAGNHIVD------IPHPYVW-------IVRKASTVKVEAIARQYITGSMWRDYsKGVRNFCGIDLPEGLRANQKLENV 167
Cdd:PRK13961 70 HIVPNHLTGidvddvVPADEADqvlgravVVKKLKPLPVECVVRGYLTGSGWKDY-QATGTVCGIKLPAGLVEASKLPEP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 168 LITPSTKgiiegvADIPPvDDVNITRANITDNLDVFNFKSAEDVTK--YEKllvegfkliSEELAkLDQ--IFVDTKFEF 243
Cdd:PRK13961 149 IFTPATK------AELGD-HDENISFEEVVELVGAELAAQLRDATLaiYKE---------AADYA-ATRgiIIADTKFEF 211
|
250 260 270
....*....|....*....|....*....|....*.
gi 490726577 244 GyvedLDGNQQLIYIDEVGTPDSSRIWDGAAYRDGK 279
Cdd:PRK13961 212 G----LDEDGTLTLMDEVLTPDSSRFWPADSYQPGT 243
|
|
| SAICAR_synt |
pfam01259 |
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase. |
21-276 |
1.25e-42 |
|
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
Pssm-ID: 460140 Cd Length: 228 Bit Score: 147.89 E-value: 1.25e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 21 VHSGKVRSVYWLTDEDsarlikeknykvpqgteLAIMVISDRISAFDCIWQgenglNGVPGKGIALNSVASHWFKLFDKA 100
Cdd:pfam01259 2 LYEGKVKDVYETDDPD-----------------TLLVVAKDRISAFDGVKK-----GTIPGKGAVNNQISAFWFELLEIA 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 101 GLAgNHIVDIPHPYVWIVRKASTVKVEAIARQYITGSMwrdyskGVRnfcgidLPeGLRANQKLENVLITPSTKgiiegv 180
Cdd:pfam01259 60 GIP-THFIKSLSGREMLVKKVKIIPLEVVVRNYAAGSL------GKR------LP-GLKEGTKLPEPIFEPSTK------ 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 181 ADIppVDDVNITRANITdnldVFNFKSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFGyvedLDGNQQLIYIDE 260
Cdd:pfam01259 120 ADA--LGDPNINEEHIV----ALGLATEEEAEEIRELALKINEILKEYAAERGIILVDTKLEFG----LDSDGEIVLADE 189
|
250
....*....|....*.
gi 490726577 261 VgTPDSSRIWDGAAYR 276
Cdd:pfam01259 190 I-TPDSSRFWDADTYE 204
|
|
| purC |
TIGR00081 |
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ... |
15-278 |
7.36e-28 |
|
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 272897 Cd Length: 237 Bit Score: 109.41 E-value: 7.36e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 15 IRTKGAVHSGKVRSVYWLTDEDsarlikeknykvpqgteLAIMVISDRISAFDCIWQGEnglngVPGKGIALNSVASHWF 94
Cdd:TIGR00081 3 IKKRQKLYSGKAKDIYETDDPD-----------------LLRFVFRDDISAFDGEKKDQ-----IPGKGRLNTKISAFIF 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 95 KLFDKAGLAgNHIVDIPHPYVWIVRKASTVKVEAIARQYITGSMWRDYSkgvrnfcgidLPEGLRanqkLENVLITPSTK 174
Cdd:TIGR00081 61 EKLEEAGIP-THYIDLIEDREMLVKKLDIIPLEVIVRNIAAGSLLKRLG----------IPEGLE----LEQPLVEFIFK 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 175 GiiEGVADippvDDVNITRAnitdnlDVFNFKSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFGyvedLDGNQQ 254
Cdd:TIGR00081 126 P--DEVGD----PMLNESYA------EALGLATEEELERIKELALKVNEVLKKYFDEKGIILVDFKLEFG----LDEEGN 189
|
250 260
....*....|....*....|....
gi 490726577 255 LIYIDEVgTPDSSRIWDGAAYRDG 278
Cdd:TIGR00081 190 LILADEV-SPDTCRLWDKETYEVG 212
|
|
| SAICAR_synt |
cd00476 |
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ... |
54-292 |
4.78e-18 |
|
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.
Pssm-ID: 133468 Cd Length: 230 Bit Score: 82.13 E-value: 4.78e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 54 LAIMVISDRISAFDCIWQgenglNGVPGKGIALNSVASHWFKLFDKAGLAgNHIVDIPHPYVWIVRKASTVKVEAIARQY 133
Cdd:cd00476 17 VLLLEFKDDISAGDGARR-----NFLDEKGDITAKLTLFIFKYLSEAGIP-THFVERLGPRTLLVDKLK*IPLEVVVRNR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 134 ITGSMWRDYskgvrnfcgidlpEGLRANQKLENVLITPSTKgiiegvADipPVDDVNITraniTDNLDVFNFKSAEDVTK 213
Cdd:cd00476 91 ATGSFVKRY-------------GGFKEGREFPPPLVEFFYK------DD--AEHDPIVS----EDQLERLGFIGKVDVER 145
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490726577 214 YEKLLVEGFKLISEELAKLDQIFVDTKFEFGyvedLDGNQQLIYIDEVgTPDSSRIWDGAAYRDGKIIENSKEGFRQLL 292
Cdd:cd00476 146 *KELAVKINTVLKKLFSPAGLELWDFKLEFG----LDEEGEIVLGDEI-SPDSSRLWRKGGEPYDKDLFRRRASLGQII 219
|
|
| SAICAR_synt_PurC |
cd01415 |
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ... |
21-271 |
3.74e-09 |
|
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.
Pssm-ID: 133470 Cd Length: 230 Bit Score: 56.31 E-value: 3.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 21 VHSGKVRSVYwLTDEDsarlikeknykvpqgtELAIMVISDRISAFDCIWQGEnglngVPGKGIALNSVASHWFKLFDKA 100
Cdd:cd01415 2 LYEGKAKIVY-ATDDP----------------DVLIVEFKDDATAFNGKKKDT-----IEGKGVLNNEISALIFKYLEEN 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 101 GLAgNHIVDIPHPYVWIVRKASTVKVEAIARQYITGSMwrdyskgVRNFcgiDLPEGlranQKLENVLITPSTKgiiegv 180
Cdd:cd01415 60 GIK-THFIEKLSDREQLVKKVEIIPLEVVVRNIAAGSL-------VKRL---GIEEG----TVLDPPIVEFYYK------ 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 181 adippvDDVN----ITRANITdnldVFNFKSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFGyvedLDGNQQLI 256
Cdd:cd01415 119 ------NDELgdplINEDHIL----ALGLATEEELKEIKELALKINEVLSEFFAEIGIILVDFKLEFG----RDKDGEIV 184
|
250
....*....|....*
gi 490726577 257 YIDEVgTPDSSRIWD 271
Cdd:cd01415 185 LADEI-SPDTCRLWD 198
|
|
| SAICAR_synt_Ade5 |
cd01416 |
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ... |
46-286 |
1.35e-07 |
|
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.
Pssm-ID: 133471 Cd Length: 252 Bit Score: 51.91 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 46 YKVPQGTELAIMVISDRISAFDCIWQGEnglngVPGKGIALNSVASHWFKLFDKAGLAgNHIVDIPHPYVWIVRKASTVK 125
Cdd:cd01416 16 YELPDQPGLVLIQSKDRITAGDGARKDE-----IEGKAAISNKTTSNVFELLQEAGIK-THFVKQCSPTAFIARKCEMIP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 126 VEAIARQYITGSMWRdyskgvRNFcgiDLPEGLRANQ-KLENVLitpstkgiiegvadippVDDVN----ITRANITDN- 199
Cdd:cd01416 90 IEWVCRRIATGSFLK------RNP---GVKEGYRFSPpKLEFFY-----------------KDDANhdpqWSEEQLLEAk 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 200 LDVFNFK-SAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFGYVEDldgNQQLIYIDeVGTPDSSRIW---DGAAY 275
Cdd:cd01416 144 LNCGGLKiGKKEVDIMTKSTIAIFEILEKAWATQDCTLVDMKIEFGVDVT---TGEILLAD-VIDNDSWRLWpsgDKRLM 219
|
250
....*....|.
gi 490726577 276 RDGKIIENSKE 286
Cdd:cd01416 220 KDKQVYRNLKE 230
|
|
| PRK09362 |
PRK09362 |
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed |
21-271 |
3.73e-07 |
|
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
Pssm-ID: 181800 Cd Length: 238 Bit Score: 50.49 E-value: 3.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 21 VHSGKVRSVYwLTDEDsarlikeknykvpqgtELAIMVISDRISAFDCIWQGEnglngVPGKGIALNSVASHWFKLFDKA 100
Cdd:PRK09362 7 LYEGKAKIVY-STDDP----------------DLLIVEFKDDATAFNGEKKEQ-----IDGKGVLNNQISSFIFKKLEEA 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 101 GLAgNHIVDIPHPYVWIVRKASTVKVEAIARQYITGSMwrdyskgVRNFcGIdlPEGLranqklenVLITPstkgIIE-G 179
Cdd:PRK09362 65 GIP-THFIEKLSDREQLVKKVEIIPLEVVVRNVAAGSL-------VKRL-GI--EEGT--------VLPPP----IVEfY 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726577 180 VADippvDDVN---ITRANITdnldVFNFKSAEDVTKYEKLLVEGFKLISEELAKLDQIFVDTKFEFGyvedLDGNQQLI 256
Cdd:PRK09362 122 YKN----DALGdpmINEDHIL----ALGWATPEELAEIKELALKINDVLKGLFAGAGIRLVDFKLEFG----RDKDGEIV 189
|
250
....*....|....*
gi 490726577 257 YIDEVgTPDSSRIWD 271
Cdd:PRK09362 190 LADEI-SPDTCRLWD 203
|
|
| |
