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Conserved domains on  [gi|490726581|ref|WP_004589074|]
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MULTISPECIES: group 1 truncated hemoglobin [Pseudoalteromonas]

Protein Classification

group I truncated hemoglobin( domain architecture ID 10087425)

group I truncated hemoglobin forms a very stable complex with oxygen; similar to Tetrahymena thermophila group 1 truncated hemoglobin

CATH:  1.10.490.10
Gene Ontology:  GO:0019825|GO:0020037|GO:0005344|GO:0046872
PubMed:  32863222|16061809|19281958|26788940|11696555
SCOP:  3000554

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrHb1_N cd00454
truncated hemoglobins (TrHbs, 2/2Hb, 2/2 globins); group 1 (N); The M- and S families exhibit ...
 27-137 2.94e-41

truncated hemoglobins (TrHbs, 2/2Hb, 2/2 globins); group 1 (N); The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. They are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). Typical of the TrHb1s (N) group is a protein matrix tunnel. It includes a Mycobacterium tuberculosis TrHb1, Mt-trHbN, which is encoded by the glbN gene. Mt-trHbN is expressed during the Mycobacterium stationary phase, and plays a specific defense role against nitrosative stress. The cyanobacterium Synechococcus sp. PCC 7002 TrHb1 GlbN, is constitutively expressed, and likely also protects cells from reactive nitrogen species.


:

Pssm-ID: 381253  Cd Length: 111  Bit Score: 133.05  E-value: 2.94e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726581  27 QQLDGRAGLTRIVDSFIYQIGNDEQVLHYFEHSDISHFREGFIMHMCMLVDGPCKYKGDSMVDIHTGMHITEKDFNHVVD 106
Cdd:cd00454    1 ERLGGEEGIEAVVDDFYDRVLADPRIKPFFAGVDMARLKKKQTEFLCEAFGGPCEYTGRDMKEAHAGLNITDEHFDAFVE 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 490726581 107 LLVNAMEEQNISHSIQNEILSRMAPLRSKII 137
Cdd:cd00454   81 HLKEALEELGVPEELIDEVLAILEPLRPDIV 111
 
Name Accession Description Interval E-value
TrHb1_N cd00454
truncated hemoglobins (TrHbs, 2/2Hb, 2/2 globins); group 1 (N); The M- and S families exhibit ...
 27-137 2.94e-41

truncated hemoglobins (TrHbs, 2/2Hb, 2/2 globins); group 1 (N); The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. They are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). Typical of the TrHb1s (N) group is a protein matrix tunnel. It includes a Mycobacterium tuberculosis TrHb1, Mt-trHbN, which is encoded by the glbN gene. Mt-trHbN is expressed during the Mycobacterium stationary phase, and plays a specific defense role against nitrosative stress. The cyanobacterium Synechococcus sp. PCC 7002 TrHb1 GlbN, is constitutively expressed, and likely also protects cells from reactive nitrogen species.


Pssm-ID: 381253  Cd Length: 111  Bit Score: 133.05  E-value: 2.94e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726581  27 QQLDGRAGLTRIVDSFIYQIGNDEQVLHYFEHSDISHFREGFIMHMCMLVDGPCKYKGDSMVDIHTGMHITEKDFNHVVD 106
Cdd:cd00454    1 ERLGGEEGIEAVVDDFYDRVLADPRIKPFFAGVDMARLKKKQTEFLCEAFGGPCEYTGRDMKEAHAGLNITDEHFDAFVE 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 490726581 107 LLVNAMEEQNISHSIQNEILSRMAPLRSKII 137
Cdd:cd00454   81 HLKEALEELGVPEELIDEVLAILEPLRPDIV 111
YjbI COG2346
Truncated hemoglobin YjbI [Inorganic ion transport and metabolism];
24-137 1.02e-29

Truncated hemoglobin YjbI [Inorganic ion transport and metabolism];


Pssm-ID: 441915  Cd Length: 120  Bit Score: 103.80  E-value: 1.02e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726581  24 SLYQQLDGRAGLTRIVDSFIYQIGNDEQVLHYFEHSDISHFREGFIMHMCMLVDGPCKYKGDSMVDIHTGMHITEKDFNH 103
Cdd:COG2346    5 TLYERIGGEEAIRALVDRFYDRVRADPLLGPIFPEADLEEHREKLADFLSQVLGGPGLYSGRRMRARHAPLPITEEHFDR 84

                         90       100       110
                 ....*....|....*....|....*....|....
gi 490726581 104 VVDLLVNAMEEQNISHSIQNEILSRMAPLRSKII 137
Cdd:COG2346   85 WLELMREALDELGVPPELAEELLARLERIADDMV 118
 
Name Accession Description Interval E-value
TrHb1_N cd00454
truncated hemoglobins (TrHbs, 2/2Hb, 2/2 globins); group 1 (N); The M- and S families exhibit ...
 27-137 2.94e-41

truncated hemoglobins (TrHbs, 2/2Hb, 2/2 globins); group 1 (N); The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. They are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). Typical of the TrHb1s (N) group is a protein matrix tunnel. It includes a Mycobacterium tuberculosis TrHb1, Mt-trHbN, which is encoded by the glbN gene. Mt-trHbN is expressed during the Mycobacterium stationary phase, and plays a specific defense role against nitrosative stress. The cyanobacterium Synechococcus sp. PCC 7002 TrHb1 GlbN, is constitutively expressed, and likely also protects cells from reactive nitrogen species.


Pssm-ID: 381253  Cd Length: 111  Bit Score: 133.05  E-value: 2.94e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726581  27 QQLDGRAGLTRIVDSFIYQIGNDEQVLHYFEHSDISHFREGFIMHMCMLVDGPCKYKGDSMVDIHTGMHITEKDFNHVVD 106
Cdd:cd00454    1 ERLGGEEGIEAVVDDFYDRVLADPRIKPFFAGVDMARLKKKQTEFLCEAFGGPCEYTGRDMKEAHAGLNITDEHFDAFVE 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 490726581 107 LLVNAMEEQNISHSIQNEILSRMAPLRSKII 137
Cdd:cd00454   81 HLKEALEELGVPEELIDEVLAILEPLRPDIV 111
YjbI COG2346
Truncated hemoglobin YjbI [Inorganic ion transport and metabolism];
24-137 1.02e-29

Truncated hemoglobin YjbI [Inorganic ion transport and metabolism];


Pssm-ID: 441915  Cd Length: 120  Bit Score: 103.80  E-value: 1.02e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726581  24 SLYQQLDGRAGLTRIVDSFIYQIGNDEQVLHYFEHSDISHFREGFIMHMCMLVDGPCKYKGDSMVDIHTGMHITEKDFNH 103
Cdd:COG2346    5 TLYERIGGEEAIRALVDRFYDRVRADPLLGPIFPEADLEEHREKLADFLSQVLGGPGLYSGRRMRARHAPLPITEEHFDR 84

                         90       100       110
                 ....*....|....*....|....*....|....
gi 490726581 104 VVDLLVNAMEEQNISHSIQNEILSRMAPLRSKII 137
Cdd:COG2346   85 WLELMREALDELGVPPELAEELLARLERIADDMV 118
TrHb cd14756
Truncated Mb-fold globins, T family; The M- and S families exhibit the canonical secondary ...
 31-134 4.61e-11

Truncated Mb-fold globins, T family; The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. They are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). Typical of the TrHb1s (N) group is a protein matrix tunnel. An example of a TrHb1 is Mycobacterium tuberculosis TrHb1/Mt-trHbN which is expressed during the Mycobacterium stationary phase, and plays a specific defense role against nitrosative stress. TrHb2s include the dimeric Arabidopsis thaliana TrHb2 AtGLB3. GLB3 is likely to have a function distinct from other plant globins: it exhibits a low O2 affinity, an unusual concentration-independent binding of O2 and CO, and does not respond to any of the treatments that induce plant 3-on-3 globins. TrHb3s include Campylobacter jejuni Ctb, encoded by Cj0465c, which may play a role in moderating O2 flux within C. jejuni.


Pssm-ID: 381270 [Multi-domain]  Cd Length: 111  Bit Score: 55.88  E-value: 4.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490726581  31 GRAGLTRIVDSFIYQIGNDEQVLHYFEHSDISHFREGFIMHMCMLVDGPCKYKGDSMVDIHTGMHITEKDFNHVVDLLVN 110
Cdd:cd14756    5 GEEAIEALVEIFYEKVLADPRLKPIFPNTDMKEHKAKQGDFLAGYLGGPNDHGGPMMRRRHLGLPITNEHFDAWLSLLAD 84

                         90       100
                 ....*....|....*....|....
gi 490726581 111 AMEEQNISHSIQNEILSRMAPLRS 134
Cdd:cd14756   85 ALDEVGVNPEMRNEILAVIEMTAR 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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