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Conserved domains on  [gi|490814919|ref|WP_004677026|]
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GFA family protein [Rhizobium esperanzae]

Protein Classification

GFA family protein( domain architecture ID 10007990)

GFA family protein similar to bacterial glutathione-dependent formaldehyde-activating enzyme, which catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione, and to eukaryotic centromere protein V, which plays a role in the distribution of pericentromeric heterochromatin in interphase nuclei

CATH:  2.170.150.70
Gene Ontology:  GO:0016846|GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3791 COG3791
Uncharacterized conserved protein [Function unknown];
9-128 6.35e-41

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443005  Cd Length: 132  Bit Score: 133.99  E-value: 6.35e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490814919   9 SGGCQCGAVRYQASAMLDNSHLCHCRMCQKASGSIFAALVAAPDDALTWTRG--KPSVWKSSELVERGFCANCGTPLFFH 86
Cdd:COG3791    5 TGSCLCGAVRFEVDGPPLRVGACHCSICRKATGSAFAAVALVPADAFRLTSGedALTTYRSSATAERHFCPTCGSPLFYR 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 490814919  87 HLENG-RTNLMIGSLDDPNAFPPLANTCTENMVTWFETVTGLE 128
Cdd:COG3791   85 RRGGPgLVAVNAGLLDDPDGLPPTAHIFTSSKPPWVEIPDGLP 127
 
Name Accession Description Interval E-value
COG3791 COG3791
Uncharacterized conserved protein [Function unknown];
9-128 6.35e-41

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443005  Cd Length: 132  Bit Score: 133.99  E-value: 6.35e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490814919   9 SGGCQCGAVRYQASAMLDNSHLCHCRMCQKASGSIFAALVAAPDDALTWTRG--KPSVWKSSELVERGFCANCGTPLFFH 86
Cdd:COG3791    5 TGSCLCGAVRFEVDGPPLRVGACHCSICRKATGSAFAAVALVPADAFRLTSGedALTTYRSSATAERHFCPTCGSPLFYR 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 490814919  87 HLENG-RTNLMIGSLDDPNAFPPLANTCTENMVTWFETVTGLE 128
Cdd:COG3791   85 RRGGPgLVAVNAGLLDDPDGLPPTAHIFTSSKPPWVEIPDGLP 127
GFA pfam04828
Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step ...
 29-108 5.22e-21

Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step in the detoxification of formaldehyde. This domain has a beta-tent fold.


Pssm-ID: 428146  Cd Length: 93  Bit Score: 82.02  E-value: 5.22e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490814919   29 HLCHCRMCQKASGSIFAALVAAPDDALTWTRGKPSVWK----SSELVERGFCANCGTPLfFHHLENGRTN--LMIGSLDD 102
Cdd:pfam04828   1 YLCHCRDCQRRSGSAFAANAVVPKEALRLTSGELKEYTdtgdSGNTVTRYFCPNCGTPL-YSESTAAPGViiVRVGTLDD 79


                  ....*.
gi 490814919  103 PNAFPP 108
Cdd:pfam04828  80 PDQLKP 85
PRK05417 PRK05417
glutathione-dependent formaldehyde-activating enzyme; Provisional
 6-84 2.71e-04

glutathione-dependent formaldehyde-activating enzyme; Provisional


Pssm-ID: 235451  Cd Length: 191  Bit Score: 39.62  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490814919   6 GDVSGG---CQCGA--VRYQASAMLDNSHLCHCRMCQKASGSIFAALVAAPDDALTWTRG--KPSVWKSSELVERGFCAN 78
Cdd:PRK05417  19 EGFAGGtlvCKCTSnpVEVRVKAQTAHNHACGCTKCWKPEGALFSVVAVVPRDNVTVTANgdKLKVVDESATIQRHACKE 98


                 ....*.
gi 490814919  79 CGTPLF 84
Cdd:PRK05417  99 CGVHMY 104
 
Name Accession Description Interval E-value
COG3791 COG3791
Uncharacterized conserved protein [Function unknown];
9-128 6.35e-41

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443005  Cd Length: 132  Bit Score: 133.99  E-value: 6.35e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490814919   9 SGGCQCGAVRYQASAMLDNSHLCHCRMCQKASGSIFAALVAAPDDALTWTRG--KPSVWKSSELVERGFCANCGTPLFFH 86
Cdd:COG3791    5 TGSCLCGAVRFEVDGPPLRVGACHCSICRKATGSAFAAVALVPADAFRLTSGedALTTYRSSATAERHFCPTCGSPLFYR 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 490814919  87 HLENG-RTNLMIGSLDDPNAFPPLANTCTENMVTWFETVTGLE 128
Cdd:COG3791   85 RRGGPgLVAVNAGLLDDPDGLPPTAHIFTSSKPPWVEIPDGLP 127
GFA pfam04828
Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step ...
 29-108 5.22e-21

Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step in the detoxification of formaldehyde. This domain has a beta-tent fold.


Pssm-ID: 428146  Cd Length: 93  Bit Score: 82.02  E-value: 5.22e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490814919   29 HLCHCRMCQKASGSIFAALVAAPDDALTWTRGKPSVWK----SSELVERGFCANCGTPLfFHHLENGRTN--LMIGSLDD 102
Cdd:pfam04828   1 YLCHCRDCQRRSGSAFAANAVVPKEALRLTSGELKEYTdtgdSGNTVTRYFCPNCGTPL-YSESTAAPGViiVRVGTLDD 79


                  ....*.
gi 490814919  103 PNAFPP 108
Cdd:pfam04828  80 PDQLKP 85
PRK05417 PRK05417
glutathione-dependent formaldehyde-activating enzyme; Provisional
 6-84 2.71e-04

glutathione-dependent formaldehyde-activating enzyme; Provisional


Pssm-ID: 235451  Cd Length: 191  Bit Score: 39.62  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490814919   6 GDVSGG---CQCGA--VRYQASAMLDNSHLCHCRMCQKASGSIFAALVAAPDDALTWTRG--KPSVWKSSELVERGFCAN 78
Cdd:PRK05417  19 EGFAGGtlvCKCTSnpVEVRVKAQTAHNHACGCTKCWKPEGALFSVVAVVPRDNVTVTANgdKLKVVDESATIQRHACKE 98


                 ....*.
gi 490814919  79 CGTPLF 84
Cdd:PRK05417  99 CGVHMY 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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