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Conserved domains on  [gi|490816211|ref|WP_004678316|]
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MULTISPECIES: HPr family phosphocarrier protein [Acinetobacter]

Protein Classification

HPr family phosphocarrier protein( domain architecture ID 10788234)

HPr family phosphocarrier protein is part of a phosphoenolpyruvate-dependent phosphotransferase (PTS)-like system that catalyzes the phosphorylation of incoming substrates with their concomitant translocation across the cell membrane

CATH:  3.30.1340.10
Gene Ontology:  GO:0008982
PubMed:  12405346
SCOP:  4001693
TCDB:  8.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-88 1.03e-33

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


:

Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 110.96  E-value: 1.03e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816211  1 MIDTTIDVINKLGLHARASGKLIEVTTRFRSSIQIGKGDKLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEIQTL 80
Cdd:COG1925   1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


                ....*...
gi 490816211 81 FAAKFYEA 88
Cdd:COG1925  81 IESGFGEE 88
 
Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-88 1.03e-33

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 110.96  E-value: 1.03e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816211  1 MIDTTIDVINKLGLHARASGKLIEVTTRFRSSIQIGKGDKLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEIQTL 80
Cdd:COG1925   1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


                ....*...
gi 490816211 81 FAAKFYEA 88
Cdd:COG1925  81 IESGFGEE 88
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
5-82 1.69e-29

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 100.15  E-value: 1.69e-29
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490816211   5 TIDVINKLGLHARASGKLIEVTTRFRSSIQIGKGDKLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEIQTLFA 82
Cdd:pfam00381  2 TVTITNPLGLHARPAALLVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALAALLE 79
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 1-82 1.30e-23

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 85.39  E-value: 1.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816211   1 MIDTTIDVINKLGLHARASGKLIEVTTRFRSSIQIGKGDKLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEIQTL 80
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKLASGFDSEITLTKNGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEALAKL 80


                 ..
gi 490816211  81 FA 82
Cdd:TIGR01003 81 FE 82
PRK13782 PRK13782
HPr family phosphocarrier protein;
1-77 3.97e-15

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 64.03  E-value: 3.97e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490816211  1 MIDTTIDVINKLGLHARASGKLIEVTTRFRSSIQIGKGDKLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEI 77
Cdd:PRK13782  1 MVQKRVEVSLKTGLQARPAALFVQEANRFHADIFIEKDGKKVNAKSIMGLMSLAIGTGSMITIITEGSDEEEALEAL 77
 
Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-88 1.03e-33

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 110.96  E-value: 1.03e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816211  1 MIDTTIDVINKLGLHARASGKLIEVTTRFRSSIQIGKGDKLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEIQTL 80
Cdd:COG1925   1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


                ....*...
gi 490816211 81 FAAKFYEA 88
Cdd:COG1925  81 IESGFGEE 88
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
5-82 1.69e-29

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 100.15  E-value: 1.69e-29
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490816211   5 TIDVINKLGLHARASGKLIEVTTRFRSSIQIGKGDKLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEIQTLFA 82
Cdd:pfam00381  2 TVTITNPLGLHARPAALLVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALAALLE 79
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 1-82 1.30e-23

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 85.39  E-value: 1.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816211   1 MIDTTIDVINKLGLHARASGKLIEVTTRFRSSIQIGKGDKLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEIQTL 80
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKLASGFDSEITLTKNGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEALAKL 80


                 ..
gi 490816211  81 FA 82
Cdd:TIGR01003 81 FE 82
PRK13782 PRK13782
HPr family phosphocarrier protein;
1-77 3.97e-15

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 64.03  E-value: 3.97e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490816211  1 MIDTTIDVINKLGLHARASGKLIEVTTRFRSSIQIGKGDKLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEI 77
Cdd:PRK13782  1 MVQKRVEVSLKTGLQARPAALFVQEANRFHADIFIEKDGKKVNAKSIMGLMSLAIGTGSMITIITEGSDEEEALEAL 77
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
 1-77 3.47e-11

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 53.93  E-value: 3.47e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490816211  1 MIDTTIDVINKLGLHARASGKLIEVTTRFRSSIQIGKGDKLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEI 77
Cdd:PRK13780  1 MASKDFHITAETGIHARPATLLVQTASKFDSDITLEYNGKSVNLKSIMGVMSLGVGQGADITISAEGADAADAIAAI 77
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 5-83 3.42e-10

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 54.50  E-value: 3.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816211   5 TIDVINKLGLHARASGKLIEVTTRFRSSI---QIGKGDKLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEIQTLF 81
Cdd:PRK13779 294 TFTIRNEHGLHARPSANLVNEVKKFTAKItveNLTRGSAPVSAKSLMKIVALGVTQGHRLRFVAEGEDAQQAIEALAKAI 373


                 ..
gi 490816211  82 AA 83
Cdd:PRK13779 374 AE 375
PRK10897 PRK10897
PTS phosphocarrier protein NPr;
5-87 3.72e-10

PTS phosphocarrier protein NPr;


Pssm-ID: 182819 [Multi-domain]  Cd Length: 90  Bit Score: 51.37  E-value: 3.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816211  5 TIDVINKLGLHARASGKLIEVTTRFRSSIQIGKGDKL-VDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEIQTLFAA 83
Cdd:PRK10897  6 TVEIKNKLGMHARPAMKLFELVQGFDAEVLLRNDEGTeAEANSVIALLMLDSAKGRQIEVEATGPQEEEALAAVIALFNS 85


                ....
gi 490816211 84 KFYE 87
Cdd:PRK10897 86 GFDE 89
PRK10850 PRK10850
phosphocarrier protein Hpr;
3-82 2.71e-09

phosphocarrier protein Hpr;


Pssm-ID: 182777 [Multi-domain]  Cd Length: 85  Bit Score: 48.97  E-value: 2.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816211  3 DTTIDVINklGLHARASGKLIEVTTRFRSSIQIGKGDKLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEIQTLFA 82
Cdd:PRK10850  5 EVTITAPN--GLHTRPAAQFVKEAKGFTSEITVTSNGKSASAKSLFKLQTLGLTQGTVVTISAEGEDEQKAVEHLVKLMA 82
PRK11109 PRK11109
fused PTS fructose transporter subunit IIA/HPr protein;
8-83 7.40e-09

fused PTS fructose transporter subunit IIA/HPr protein;


Pssm-ID: 236849 [Multi-domain]  Cd Length: 375  Bit Score: 50.72  E-value: 7.40e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490816211   8 VINKLGLHARASGKLIEVTTRFRSSIQIGKGD---KLVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEIQTLFAA 83
Cdd:PRK11109 292 IRNEHGLHARPGAMLVNTIKQFNSEITVTNLDgtgKPANGRSLMKVVALGVKKGHRLRFTAQGEDAEQALKAIGEAIAA 370
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 2-83 1.19e-08

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 50.26  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816211   2 IDTTIDVINKLGLHARASGKLIEVTTRFRSSIQIGKGDK---LVDAKNIMSLLMLGAGKGTTLRLVIDGADEDKALEEIQ 78
Cdd:PRK13779 415 VEGVFVIKNEHGLHARPSAVLVNEVKKYNASVAVQNLDRntqLVSAKSLMKIVALGVVKGHRLRFVATGEEAQQAIDGIG 494


                 ....*
gi 490816211  79 TLFAA 83
Cdd:PRK13779 495 AAIAA 499
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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