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Conserved domains on  [gi|490816258|ref|WP_004678363|]
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MULTISPECIES: proton-translocating transhydrogenase family protein [Acinetobacter]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pntA super family cl35827
Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha;
6-98 2.90e-40

Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha;


The actual alignment was detected with superfamily member PRK09424:

Pssm-ID: 236507 [Multi-domain]  Cd Length: 509  Bit Score: 138.81  E-value: 2.90e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816258   6 TIFVLAIFVGYYVVWGVTPALHTPLMAVTNALSSIIIVGAMIQtvgmpvIGvdanvafQSVNVVSILGAIAVFLASINIF 85
Cdd:PRK09424 428 TVFVLACVVGYYVVWNVSHALHTPLMSVTNAISGIIVVGALLQ------IG-------SGSGLVTFLAFIAVLIASINIF 494

                         90
                 ....*....|...
gi 490816258  86 GGFAVTARMLEMF 98
Cdd:PRK09424 495 GGFTVTQRMLKMF 507
 
Name Accession Description Interval E-value
pntA PRK09424
Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha;
6-98 2.90e-40

Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha;


Pssm-ID: 236507 [Multi-domain]  Cd Length: 509  Bit Score: 138.81  E-value: 2.90e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816258   6 TIFVLAIFVGYYVVWGVTPALHTPLMAVTNALSSIIIVGAMIQtvgmpvIGvdanvafQSVNVVSILGAIAVFLASINIF 85
Cdd:PRK09424 428 TVFVLACVVGYYVVWNVSHALHTPLMSVTNAISGIIVVGALLQ------IG-------SGSGLVTFLAFIAVLIASINIF 494

                         90
                 ....*....|...
gi 490816258  86 GGFAVTARMLEMF 98
Cdd:PRK09424 495 GGFTVTQRMLKMF 507
PNTB_4TM pfam12769
4TM region of pyridine nucleotide transhydrogenase, mitoch; PNTB_4TM is the region upstream of ...
 5-99 8.53e-38

4TM region of pyridine nucleotide transhydrogenase, mitoch; PNTB_4TM is the region upstream of family PNTB, pfam02233, that carries four of this transporters transmembrane regions. PNTB is the beta-subunit of pyridine nucleotide transhydrogenase. This family forms part of the Proton-translocating Transhydrogenase (PTH) Family.


Pssm-ID: 463694 [Multi-domain]  Cd Length: 84  Bit Score: 121.79  E-value: 8.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816258    5 ITIFVLAIFVGYYVVWGVTPALHTPLMAVTNALSSIIIVGAMIQtvgmpvigvdanVAFQSVNVVSILGAIAVFLASINI 84
Cdd:pfam12769   1 LTVFVLALFVGYEVIWKVPPALHTPLMSVTNAISGIIIVGALLA------------AGGGDTTLATVLGFIAVVLATINV 68

                          90
                  ....*....|....*
gi 490816258   85 FGGFAVTARMLEMFK 99
Cdd:pfam12769  69 VGGFLVTDRMLDMFK 83
pntA TIGR00561
NAD(P) transhydrogenase, alpha subunit; This integral membrane protein is the alpha subunit of ...
 6-99 7.94e-29

NAD(P) transhydrogenase, alpha subunit; This integral membrane protein is the alpha subunit of alpha 2 beta 2 tetramer that couples the proton transport across the membrane to the reversible transfer of hydride ion equivalents between NAD and NADP. An alternate name is pyridine nucleotide transhydrogenase alpha subunit. The N-terminal region is homologous to alanine dehydrogenase. In some species, such as Rhodospirillum rubrum, the alpha chain is replaced by two shorter chains, both with some homology to the full-length alpha chain modeled here. These score below the trusted cutoff. [Energy metabolism, Electron transport]


Pssm-ID: 273140 [Multi-domain]  Cd Length: 512  Bit Score: 107.83  E-value: 7.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816258    6 TIFVLAIFVGYYVVWGVTPALHTPLMAVTNALSSIIIVGAMIQtvgmpvIGVDANVAFqsvnvVSILGAIAVFLASINIF 85
Cdd:TIGR00561 428 TVFALACVVGYYVVWNVSHALHTPLMAVTNAISGIIIVGALLQ------IGQGGGNLF-----IDALAFIAILIASINIF 496

                          90
                  ....*....|....
gi 490816258   86 GGFAVTARMLEMFK 99
Cdd:TIGR00561 497 GGFRVTQRMLAMFR 510
PntA COG3288
NAD/NADP transhydrogenase alpha subunit [Energy production and conversion];
11-101 6.80e-08

NAD/NADP transhydrogenase alpha subunit [Energy production and conversion];


Pssm-ID: 442518 [Multi-domain]  Cd Length: 359  Bit Score: 48.46  E-value: 6.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816258  11 AIFVGYYVVWGVTPALHT--PLMAVTNA---LSSIIIVGAMIQtvGMPVIG-------------VDANVAFQsvnvVSIL 72
Cdd:COG3288  133 ANFAGYKAVLLAAPALHTffPLMSTAAGtirPAGVLVVGAGVA--GLQAIAtakrlgavveaydVRPAVKEQ----VESL 206

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490816258  73 GAIAVFLA-SINIFGGFA---------------------------------------VTARMLEMFKPK 101
Cdd:COG3288  207 GAKFVELAiDANGAGGYAkelseeekakqaellaehiakadivittalipgrpapflVTERMLAMMKPG 275
 
Name Accession Description Interval E-value
pntA PRK09424
Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha;
6-98 2.90e-40

Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha;


Pssm-ID: 236507 [Multi-domain]  Cd Length: 509  Bit Score: 138.81  E-value: 2.90e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816258   6 TIFVLAIFVGYYVVWGVTPALHTPLMAVTNALSSIIIVGAMIQtvgmpvIGvdanvafQSVNVVSILGAIAVFLASINIF 85
Cdd:PRK09424 428 TVFVLACVVGYYVVWNVSHALHTPLMSVTNAISGIIVVGALLQ------IG-------SGSGLVTFLAFIAVLIASINIF 494

                         90
                 ....*....|...
gi 490816258  86 GGFAVTARMLEMF 98
Cdd:PRK09424 495 GGFTVTQRMLKMF 507
PNTB_4TM pfam12769
4TM region of pyridine nucleotide transhydrogenase, mitoch; PNTB_4TM is the region upstream of ...
 5-99 8.53e-38

4TM region of pyridine nucleotide transhydrogenase, mitoch; PNTB_4TM is the region upstream of family PNTB, pfam02233, that carries four of this transporters transmembrane regions. PNTB is the beta-subunit of pyridine nucleotide transhydrogenase. This family forms part of the Proton-translocating Transhydrogenase (PTH) Family.


Pssm-ID: 463694 [Multi-domain]  Cd Length: 84  Bit Score: 121.79  E-value: 8.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816258    5 ITIFVLAIFVGYYVVWGVTPALHTPLMAVTNALSSIIIVGAMIQtvgmpvigvdanVAFQSVNVVSILGAIAVFLASINI 84
Cdd:pfam12769   1 LTVFVLALFVGYEVIWKVPPALHTPLMSVTNAISGIIIVGALLA------------AGGGDTTLATVLGFIAVVLATINV 68

                          90
                  ....*....|....*
gi 490816258   85 FGGFAVTARMLEMFK 99
Cdd:pfam12769  69 VGGFLVTDRMLDMFK 83
pntA TIGR00561
NAD(P) transhydrogenase, alpha subunit; This integral membrane protein is the alpha subunit of ...
 6-99 7.94e-29

NAD(P) transhydrogenase, alpha subunit; This integral membrane protein is the alpha subunit of alpha 2 beta 2 tetramer that couples the proton transport across the membrane to the reversible transfer of hydride ion equivalents between NAD and NADP. An alternate name is pyridine nucleotide transhydrogenase alpha subunit. The N-terminal region is homologous to alanine dehydrogenase. In some species, such as Rhodospirillum rubrum, the alpha chain is replaced by two shorter chains, both with some homology to the full-length alpha chain modeled here. These score below the trusted cutoff. [Energy metabolism, Electron transport]


Pssm-ID: 273140 [Multi-domain]  Cd Length: 512  Bit Score: 107.83  E-value: 7.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816258    6 TIFVLAIFVGYYVVWGVTPALHTPLMAVTNALSSIIIVGAMIQtvgmpvIGVDANVAFqsvnvVSILGAIAVFLASINIF 85
Cdd:TIGR00561 428 TVFALACVVGYYVVWNVSHALHTPLMAVTNAISGIIIVGALLQ------IGQGGGNLF-----IDALAFIAILIASINIF 496

                          90
                  ....*....|....
gi 490816258   86 GGFAVTARMLEMFK 99
Cdd:TIGR00561 497 GGFRVTQRMLAMFR 510
PntA COG3288
NAD/NADP transhydrogenase alpha subunit [Energy production and conversion];
11-101 6.80e-08

NAD/NADP transhydrogenase alpha subunit [Energy production and conversion];


Pssm-ID: 442518 [Multi-domain]  Cd Length: 359  Bit Score: 48.46  E-value: 6.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490816258  11 AIFVGYYVVWGVTPALHT--PLMAVTNA---LSSIIIVGAMIQtvGMPVIG-------------VDANVAFQsvnvVSIL 72
Cdd:COG3288  133 ANFAGYKAVLLAAPALHTffPLMSTAAGtirPAGVLVVGAGVA--GLQAIAtakrlgavveaydVRPAVKEQ----VESL 206

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490816258  73 GAIAVFLA-SINIFGGFA---------------------------------------VTARMLEMFKPK 101
Cdd:COG3288  207 GAKFVELAiDANGAGGYAkelseeekakqaellaehiakadivittalipgrpapflVTERMLAMMKPG 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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