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Conserved domains on  [gi|490821332|ref|WP_004683429|]
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MULTISPECIES: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA [Brucella]

Protein Classification

4-hydroxythreonine-4-phosphate dehydrogenase PdxA( domain architecture ID 10012313)

4-hydroxythreonine-4-phosphate dehydrogenase PdxA catalyzes the oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid, which decarboxylates to form 3-amino-2-oxopropyl phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pdxA PRK05312
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
7-339 0e+00

4-hydroxythreonine-4-phosphate dehydrogenase PdxA;


:

Pssm-ID: 235402  Cd Length: 336  Bit Score: 568.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   7 PPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVDFAILSDPREAEAAFGERLPLLALKHS 86
Cdd:PRK05312   4 RPLALSLGDPAGIGPEIALKAWLRRRELGLPPFFLIGDPAVLAARARLLGLDVPVAEVTDPEEAAAVFADALPVLPLPFP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  87 HTESPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHLGKPVTPVMMLAGP 166
Cdd:PRK05312  84 APVVPGQPDPANAAGVIAAIERAVGLVLSGEAAAVVTAPIAKKVLYDAGFAFPGHTEFLAELAGVATGKPVQPVMMLAGP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 167 QLRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAIEQLIRE 246
Cdd:PRK05312 164 QLRVVPVTIHIPLRDVPAALTPELIVATARITAADLRRRFGIASPRLAVAGLNPHAGEGGALGREDIDIIAPAIEQLRAE 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 247 GIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDSLVA 326
Cdd:PRK05312 244 GIDARGPLPADTMFHAAARATYDAAICMYHDQALIPIKTLDFDGGVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDSLIA 323

                        330
                 ....*....|...
gi 490821332 327 AMRLAQQLAENAA 339
Cdd:PRK05312 324 ALRLAAQMAANRA 336
 
Name Accession Description Interval E-value
pdxA PRK05312
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
7-339 0e+00

4-hydroxythreonine-4-phosphate dehydrogenase PdxA;


Pssm-ID: 235402  Cd Length: 336  Bit Score: 568.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   7 PPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVDFAILSDPREAEAAFGERLPLLALKHS 86
Cdd:PRK05312   4 RPLALSLGDPAGIGPEIALKAWLRRRELGLPPFFLIGDPAVLAARARLLGLDVPVAEVTDPEEAAAVFADALPVLPLPFP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  87 HTESPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHLGKPVTPVMMLAGP 166
Cdd:PRK05312  84 APVVPGQPDPANAAGVIAAIERAVGLVLSGEAAAVVTAPIAKKVLYDAGFAFPGHTEFLAELAGVATGKPVQPVMMLAGP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 167 QLRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAIEQLIRE 246
Cdd:PRK05312 164 QLRVVPVTIHIPLRDVPAALTPELIVATARITAADLRRRFGIASPRLAVAGLNPHAGEGGALGREDIDIIAPAIEQLRAE 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 247 GIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDSLVA 326
Cdd:PRK05312 244 GIDARGPLPADTMFHAAARATYDAAICMYHDQALIPIKTLDFDGGVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDSLIA 323

                        330
                 ....*....|...
gi 490821332 327 AMRLAQQLAENAA 339
Cdd:PRK05312 324 ALRLAAQMAANRA 336
PdxA COG1995
4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; ...
 5-339 2.48e-165

4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; 4-hydroxy-L-threonine phosphate dehydrogenase PdxA is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis


Pssm-ID: 441598  Cd Length: 330  Bit Score: 464.15  E-value: 2.48e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   5 PLPPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVDFAILSDPREAEAAFGeRLPLLALK 84
Cdd:COG1995    1 TKPRIAITMGDPAGIGPEIILKALADPRILELCRPVVIGDPKVLERAAKQLGLDLPLREIDSPAEAAANPG-TLNVLDVG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  85 HSHTE-SPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHlgkpvTPVMML 163
Cdd:COG1995   80 NDAAPvEPGKPSAAAGRAALESLERAVELALAGEIDALVTAPINKEAINAAGFPFPGHTEFLAELTGTK-----DVVMML 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 164 AGPQLRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAIEQL 243
Cdd:COG1995  155 AGEGLRVALVTTHIPLRDVPDAITPERILETIRLLHRALRRDFGIAKPRIAVAGLNPHAGEGGLFGREEIDIIAPAIEAA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 244 IREGIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDS 323
Cdd:COG1995  235 RAEGIDVSGPLPADTLFHRAARGEYDAVLAMYHDQGLIPLKLLGFDRGVNVTLGLPFIRTSVDHGTAFDIAGKGIADPGS 314

                        330
                 ....*....|....*.
gi 490821332 324 LVAAMRLAQQLAENAA 339
Cdd:COG1995  315 LIAAIRLAARLARNRR 330
pdxA TIGR00557
4-hydroxythreonine-4-phosphate dehydrogenase; This model represents PdxA, an NAD+-dependent ...
 8-335 1.05e-164

4-hydroxythreonine-4-phosphate dehydrogenase; This model represents PdxA, an NAD+-dependent 4-hydroxythreonine 4-phosphate dehydrogenase (EC 1.1.1.262) active in pyridoxal phosphate biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine]


Pssm-ID: 273137  Cd Length: 320  Bit Score: 461.95  E-value: 1.05e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332    8 PLAVSIGDPSGIGADVALAAWLKRceLSLPPFFLIADPKQLAARARHLGLaVDFAILSDPREAEAAFGERLPLLALKHSH 87
Cdd:TIGR00557   1 RIAITLGDPAGIGPEIILKALAQL--AELCPPVVIGDPALLEARAKLLGL-LPLVAIDAPEDAAAAFPGALPVLPVPLAA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   88 TESPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHhlgkpVTPVMMLAGPQ 167
Cdd:TIGR00557  78 PVTPGKPDPANGAAVFETLERAVELCLAGEADALVTAPIHKGAINAAGFPFPGHTEFLAELTGV-----PDVVMMLAGPG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  168 LRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAIEQLIREG 247
Cdd:TIGR00557 153 LRVALATTHIPLKDVPAALTPELLLEKLRILHADLRRDFGIARPRIAVAGLNPHAGEGGHLGREEIDIIIPALEALRAEG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  248 IDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDSLVAA 327
Cdd:TIGR00557 233 IDLIGPLPADTLFHPAALAKYDAVLAMYHDQGLIPLKYLGFDEGVNVTLGLPFIRTSPDHGTAFDIAGKGKADPGSLIAA 312


                  ....*...
gi 490821332  328 MRLAQQLA 335
Cdd:TIGR00557 313 IKLAIELA 320
PdxA pfam04166
Pyridoxal phosphate biosynthetic protein PdxA; In Escherichia coli the coenzyme pyridoxal 5 ...
 91-331 3.75e-128

Pyridoxal phosphate biosynthetic protein PdxA; In Escherichia coli the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that is thought to involve the condensation of 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose, catalyzed by the enzymes PdxA and PdxJ, to form either pyridoxine (vitamin B6) or pyridoxine 5'-phosphate.


Pssm-ID: 461203  Cd Length: 251  Bit Score: 366.71  E-value: 3.75e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   91 PGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHlgkpvTPVMMLAGPQLRA 170
Cdd:pfam04166  16 PGKPSAESGAAALAYLERAVELALAGEFDALVTAPINKEAINAAGFPFPGHTEYLAELTGTK-----DVVMMLAGEGLRV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  171 VPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAIEQLIREGIDA 250
Cdd:pfam04166  91 ALVTTHIPLKDVPAAITPERILEKIRLLHKALKRDFGIANPRIAVAGLNPHAGEGGLFGREEIEIIIPAIEKARAEGIDV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  251 RGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDSLVAAMRL 330
Cdd:pfam04166 171 FGPLPADTLFGKAARGKFDAVLAMYHDQGLIPLKTLGFDRGVNVTLGLPIIRTSVDHGTAFDIAGKGIADPGSLREAIRL 250


                  .
gi 490821332  331 A 331
Cdd:pfam04166 251 A 251
 
Name Accession Description Interval E-value
pdxA PRK05312
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
7-339 0e+00

4-hydroxythreonine-4-phosphate dehydrogenase PdxA;


Pssm-ID: 235402  Cd Length: 336  Bit Score: 568.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   7 PPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVDFAILSDPREAEAAFGERLPLLALKHS 86
Cdd:PRK05312   4 RPLALSLGDPAGIGPEIALKAWLRRRELGLPPFFLIGDPAVLAARARLLGLDVPVAEVTDPEEAAAVFADALPVLPLPFP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  87 HTESPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHLGKPVTPVMMLAGP 166
Cdd:PRK05312  84 APVVPGQPDPANAAGVIAAIERAVGLVLSGEAAAVVTAPIAKKVLYDAGFAFPGHTEFLAELAGVATGKPVQPVMMLAGP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 167 QLRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAIEQLIRE 246
Cdd:PRK05312 164 QLRVVPVTIHIPLRDVPAALTPELIVATARITAADLRRRFGIASPRLAVAGLNPHAGEGGALGREDIDIIAPAIEQLRAE 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 247 GIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDSLVA 326
Cdd:PRK05312 244 GIDARGPLPADTMFHAAARATYDAAICMYHDQALIPIKTLDFDGGVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDSLIA 323

                        330
                 ....*....|...
gi 490821332 327 AMRLAQQLAENAA 339
Cdd:PRK05312 324 ALRLAAQMAANRA 336
PdxA COG1995
4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; ...
 5-339 2.48e-165

4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; 4-hydroxy-L-threonine phosphate dehydrogenase PdxA is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis


Pssm-ID: 441598  Cd Length: 330  Bit Score: 464.15  E-value: 2.48e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   5 PLPPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVDFAILSDPREAEAAFGeRLPLLALK 84
Cdd:COG1995    1 TKPRIAITMGDPAGIGPEIILKALADPRILELCRPVVIGDPKVLERAAKQLGLDLPLREIDSPAEAAANPG-TLNVLDVG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  85 HSHTE-SPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHlgkpvTPVMML 163
Cdd:COG1995   80 NDAAPvEPGKPSAAAGRAALESLERAVELALAGEIDALVTAPINKEAINAAGFPFPGHTEFLAELTGTK-----DVVMML 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 164 AGPQLRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAIEQL 243
Cdd:COG1995  155 AGEGLRVALVTTHIPLRDVPDAITPERILETIRLLHRALRRDFGIAKPRIAVAGLNPHAGEGGLFGREEIDIIAPAIEAA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 244 IREGIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDS 323
Cdd:COG1995  235 RAEGIDVSGPLPADTLFHRAARGEYDAVLAMYHDQGLIPLKLLGFDRGVNVTLGLPFIRTSVDHGTAFDIAGKGIADPGS 314

                        330
                 ....*....|....*.
gi 490821332 324 LVAAMRLAQQLAENAA 339
Cdd:COG1995  315 LIAAIRLAARLARNRR 330
pdxA TIGR00557
4-hydroxythreonine-4-phosphate dehydrogenase; This model represents PdxA, an NAD+-dependent ...
 8-335 1.05e-164

4-hydroxythreonine-4-phosphate dehydrogenase; This model represents PdxA, an NAD+-dependent 4-hydroxythreonine 4-phosphate dehydrogenase (EC 1.1.1.262) active in pyridoxal phosphate biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine]


Pssm-ID: 273137  Cd Length: 320  Bit Score: 461.95  E-value: 1.05e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332    8 PLAVSIGDPSGIGADVALAAWLKRceLSLPPFFLIADPKQLAARARHLGLaVDFAILSDPREAEAAFGERLPLLALKHSH 87
Cdd:TIGR00557   1 RIAITLGDPAGIGPEIILKALAQL--AELCPPVVIGDPALLEARAKLLGL-LPLVAIDAPEDAAAAFPGALPVLPVPLAA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   88 TESPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHhlgkpVTPVMMLAGPQ 167
Cdd:TIGR00557  78 PVTPGKPDPANGAAVFETLERAVELCLAGEADALVTAPIHKGAINAAGFPFPGHTEFLAELTGV-----PDVVMMLAGPG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  168 LRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAIEQLIREG 247
Cdd:TIGR00557 153 LRVALATTHIPLKDVPAALTPELLLEKLRILHADLRRDFGIARPRIAVAGLNPHAGEGGHLGREEIDIIIPALEALRAEG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  248 IDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDSLVAA 327
Cdd:TIGR00557 233 IDLIGPLPADTLFHPAALAKYDAVLAMYHDQGLIPLKYLGFDEGVNVTLGLPFIRTSPDHGTAFDIAGKGKADPGSLIAA 312


                  ....*...
gi 490821332  328 MRLAQQLA 335
Cdd:TIGR00557 313 IKLAIELA 320
PdxA pfam04166
Pyridoxal phosphate biosynthetic protein PdxA; In Escherichia coli the coenzyme pyridoxal 5 ...
 91-331 3.75e-128

Pyridoxal phosphate biosynthetic protein PdxA; In Escherichia coli the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that is thought to involve the condensation of 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose, catalyzed by the enzymes PdxA and PdxJ, to form either pyridoxine (vitamin B6) or pyridoxine 5'-phosphate.


Pssm-ID: 461203  Cd Length: 251  Bit Score: 366.71  E-value: 3.75e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   91 PGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHlgkpvTPVMMLAGPQLRA 170
Cdd:pfam04166  16 PGKPSAESGAAALAYLERAVELALAGEFDALVTAPINKEAINAAGFPFPGHTEYLAELTGTK-----DVVMMLAGEGLRV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  171 VPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAIEQLIREGIDA 250
Cdd:pfam04166  91 ALVTTHIPLKDVPAAITPERILEKIRLLHKALKRDFGIANPRIAVAGLNPHAGEGGLFGREEIEIIIPAIEKARAEGIDV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  251 RGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDSLVAAMRL 330
Cdd:pfam04166 171 FGPLPADTLFGKAARGKFDAVLAMYHDQGLIPLKTLGFDRGVNVTLGLPIIRTSVDHGTAFDIAGKGIADPGSLREAIRL 250


                  .
gi 490821332  331 A 331
Cdd:pfam04166 251 A 251
pdxA PRK00232
4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed
 6-339 1.40e-107

4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed


Pssm-ID: 234696  Cd Length: 332  Bit Score: 317.49  E-value: 1.40e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   6 LPPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVDFAILSDPREAEAAFGERLPLLALKH 85
Cdd:PRK00232   4 KPRIAITPGDPAGIGPELVAKLLAQPDVRWPAELVVIADRALLERRAAILGLPLDLRPYSPDAPAQPQEAGTLTVLPVPL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  86 SHTESPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHLgkpvtPVMMLAG 165
Cdd:PRK00232  84 APAVVAGQLDAANGRYVLETLARALDGCLAGEFDAICTAPVNKGAINDAGIPFSGHTEFFAELSGTTG-----VVMMLAT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 166 PQLRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERfGIASPRLAISGLNPHAGEGGALGKEDDAIILPAIEQLIR 245
Cdd:PRK00232 159 EGLRVALVTTHLPLRDVADAITPERLEEVIRILHADLRRK-GIAEPRIAVCGLNPHAGEGGHFGREEIDIIIPALEELRA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 246 EGIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDSLV 325
Cdd:PRK00232 238 EGINLVGPLPADTLFQPAYLGDADAVLAMYHDQGLPVLKYLGFGRGVNITLGLPFIRTSVDHGTALDLAGKGIADVGSFI 317

                        330
                 ....*....|....
gi 490821332 326 AAMRLAQQLAENAA 339
Cdd:PRK00232 318 TALNLAIRMAANRR 331
pdxA PRK02746
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
1-337 6.15e-96

4-hydroxythreonine-4-phosphate dehydrogenase PdxA;


Pssm-ID: 235066  Cd Length: 345  Bit Score: 288.34  E-value: 6.15e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   1 MRAKPLPPLAVSIGDPSGIGADVALAAWlkrCELSLPP---FFLIADPKQLAARARHLgLAVDFAILSDPreaeaafgER 77
Cdd:PRK02746   4 EDSDPRPRLAITLGDPAGIGPEVILKAL---ASPELPEncqPTLVGCRSLLEQTYQRL-KSQGIEPLADP--------AN 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  78 LPLLALKHSHTESPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGhhlgkpV 157
Cdd:PRK02746  72 LDILDIPLDSTIIPGKGNAASGAASFAYLTTAIEITLAGEFDAIVTAPIAKSAWHAAGHHYPGQTEVLAELAG------V 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 158 TPVMML-------AGPQLRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGK 230
Cdd:PRK02746 146 ERFGMLftarsphTGWRLRTLLATTHIPLCQVPKTLTPELITSKLDLLIDFLQRDFGIEKPRIAIAGLNPHAGEQGQLGT 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 231 EDDAIILPAIEQLIREGIDAR--GPLPADTMFHAPARA--------TYDAAICMYHDQALIPAKALAFDETVNVTLGLPF 300
Cdd:PRK02746 226 EEKDWLIPWLESWRQKNPDIQllGPIPPDTCWVSPAQAwygkgvaeAPDGYLALYHDQGLIPVKLMAFDRAVNTTIGLPF 305

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 490821332 301 IRTSPDHGTAFDIAGKGIARPDSLVAAMRLAQQLAEN 337
Cdd:PRK02746 306 IRTSPDHGTAFDIAGKGIARPQSMKAAIKLAWELSKQ 342
pdxA PRK03743
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
7-337 3.25e-73

4-hydroxythreonine-4-phosphate dehydrogenase PdxA;


Pssm-ID: 179641  Cd Length: 332  Bit Score: 229.88  E-value: 3.25e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   7 PPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVDFAILSDPREAEAAFGErLPLLALKHS 86
Cdd:PRK03743   4 PIIAIPIGDPAGIGPEIVVKTLADKEVYDECKPFLIGDAPVIERAMKICGVDLNINKIKKPAEGKFEWGT-IDLIDLGNY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  87 HTESP--GKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHlgkpvTPVMMLA 164
Cdd:PRK03743  83 DCDSIkwGKVQALAGKAAFEYIKKSVELAMEGKVDAVATTPINKEALKAAGVKYIGHTEILADLTGTE-----DPLTMFE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 165 GPQLRAVPVTIHIPLSEVPARLTTTEIVA-VSRITAnELrERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAIEQL 243
Cdd:PRK03743 158 VRNLRVFFLTRHVSLKKACDYVTKERVLDyIQRCTK-AL-EKLGIKNPKIAVAGLNPHSGEHGLFGDEEVDEIIPAVEAA 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 244 IREGIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDS 323
Cdd:PRK03743 236 QEMGINVEGPVPADSVFHLALQGRYDAVLSLYHDQGHIATKTLDFERTIAITNGLPFLRTSVDHGTAFDIAGTGKASSVS 315

                        330
                 ....*....|....
gi 490821332 324 LVAAMRLAQQLAEN 337
Cdd:PRK03743 316 MEEAILLAAKYAPM 329
pdxA PRK01909
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
5-341 4.22e-72

4-hydroxythreonine-4-phosphate dehydrogenase PdxA;


Pssm-ID: 234991  Cd Length: 329  Bit Score: 226.93  E-value: 4.22e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   5 PLPPLAVSIGDPSGIGADVAL-AAWLKRCELSLPPFFLIADPKQLAARARHLGlaVDFAILSdpREAEAAFGERlPLLAL 83
Cdd:PRK01909   4 QPLQIAITTGEPAGVGPELTVrALADAAARWPDARFTVLGDAALLAARAAAVG--ADWARLA--AGGHVTVAHR-PLAAP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  84 KHshtesPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGhhlgkpvTP--VM 161
Cdd:PRK01909  79 AE-----AGKLDAANGRYVLDLLDAAIDGALAGRYDAIVTAPLQKSTINDAGVPFTGHTEYLAERTH-------TPrvVM 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 162 MLAG--PQ-LRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILP 238
Cdd:PRK01909 147 MLAGtgPRpLRVALATTHLPLKDVSAALTIDGLVETLAIIDRDLRRDFGLAAPRILVTGLNPHAGENGYLGREEIDVIEP 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 239 AIEQLIREGIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGI 318
Cdd:PRK01909 227 ALARARAAGIDARGPYPADTLFQPRYLEDADCVLAMFHDQGLPVLKYATFGEGINVTLGLPIIRTSVDHGTALDLAGTGR 306

                        330       340
                 ....*....|....*....|...
gi 490821332 319 ARPDSLVAAMRLAQQLAENAASR 341
Cdd:PRK01909 307 ADPGSMIAAIDTAVTMARHRRAS 329
pdxA PRK03371
D-threonate 4-phosphate dehydrogenase;
9-335 4.94e-67

D-threonate 4-phosphate dehydrogenase;


Pssm-ID: 179572  Cd Length: 326  Bit Score: 213.92  E-value: 4.94e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   9 LAVSIGDPSGIGADVALAAwLKRCELSLPPFFLIADPKQLAaRARHLGLA--VDFAILSDPREAEAAFGeRLPLLALKHS 86
Cdd:PRK03371   5 IAVTMGDPAGIGPEIIIKS-LSEGGLNGAPLVVVGCLATLR-RILAKGITpqVELRAIERVAEARFAPG-IINVIDEPLA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  87 HTES--PGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAelaghHLGKPVTPVMMLA 164
Cdd:PRK03371  82 QPEAlePGVVQAQAGDLAYRCVKRATELALRGEVQAIATAPLNKEALHLAGHNYPGHTELLA-----TLTHSRDYAMVLY 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 165 GPQLRAVPVTIHIPLSEVPARLTTTEIVAVSRItANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAIEQLI 244
Cdd:PRK03371 157 TDKLKVIHVSTHIALRKFLDTLNTARVETVIGI-ADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEEIRIVTPAIEAMR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 245 REGIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIARPDSL 324
Cdd:PRK03371 236 AKGMDVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAFDIAWTGKAKSESM 315

                        330
                 ....*....|.
gi 490821332 325 VAAMRLAQQLA 335
Cdd:PRK03371 316 AVSIKLAMQLA 326
pdxA PRK03946
4-hydroxythreonine-4-phosphate dehydrogenase; Provisional
 6-338 7.19e-63

4-hydroxythreonine-4-phosphate dehydrogenase; Provisional


Pssm-ID: 179681  Cd Length: 307  Bit Score: 202.53  E-value: 7.19e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332   6 LPPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVDFAIlsdpreaeaaFGERLPLLALKh 85
Cdd:PRK03946   1 KKKIAISIGDINGIGLEIALKSHDEVSKICEPLYCINEELLEQAAKLLNLKTPNDFEI----------DFPVGLLFEIK- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332  86 shtesPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHlgkpvtPVMMLAG 165
Cdd:PRK03946  70 -----PGKVSAKSGAYSFESFKKAVELADSKEVDAIVTLPINKKAWQKAGIPYKGHTDALRDRFKKE------AIMMLGC 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 166 PQLRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERfgiaspRLAISGLNPHAGEGGALGKEDDaIILPAIE---- 241
Cdd:PRK03946 139 EELFVALFTDHIPLKKVSQLIKVKKLVKFLLDFYKSTKFK------KIGVLGLNPHAGDNGVIGGEEE-EIKKAIKkanq 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490821332 242 QLIREGIdaRGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGI-AR 320
Cdd:PRK03946 212 FLGFEIF--FGPLVPDSAFTPNKRKKFNYYVAMYHDQGLAPLKALYFDESINVSLNLPILRTSVDHGTAFDIAYKNAkAN 289

                        330
                 ....*....|....*...
gi 490821332 321 PDSLVAAMRLAQQLAENA 338
Cdd:PRK03946 290 TKSYLNAIKYAINLLSKK 307
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
305-341 7.12e-03

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 38.04  E-value: 7.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 490821332  305 PDHGTAFDIAGKGIARPDSLV--AAMRLAQQLAENAASR 341
Cdd:pfam00180 273 PVHGSAPDIAGKGIANPIATIlsAAMMLRYSLGLEDAAD 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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