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Conserved domains on  [gi|490826380|ref|WP_004688470|]
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DUF192 domain-containing protein [Brucella neotomae]

Protein Classification

DUF192 domain-containing protein( domain architecture ID 10003666)

DUF192 domain-containing protein similar to Methanocaldococcus jannaschii UPF0127 protein MJ1496

CATH:  2.60.120.1140
SCOP:  4007008

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG1430 COG1430
Uncharacterized conserved membrane protein, UPF0127 family [Function unknown];
11-153 4.82e-45

Uncharacterized conserved membrane protein, UPF0127 family [Function unknown];


:

Pssm-ID: 441039  Cd Length: 138  Bit Score: 144.28  E-value: 4.82e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490826380  11 MFVAFVAradeAQPMRLPVDKEQLIFITSTgnkINFALEVADTDEARVRGLMWRTDFPKDRAMIFILGEMRRIVMWMQNT 90
Cdd:COG1430    1 MLLALLL----LALAAAALPTGELTINTAG---LAIDVEVADTFEERARGLMFRKSLPEDEGMLFVFDEPRCRSFWMKNT 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490826380  91 PLPLDMVFLDDKGRVVAIHENAVPFSENLISSEVPAAYAVELLAGTVKRTGIKVGDRAIHRVI 153
Cdd:COG1430   74 RFPLDIIFLDADGRIVSIAENLPPCSWTSYPSGGPARYVLELPAGWAARLGIKVGDRLEIEPL 136
 
Name Accession Description Interval E-value
COG1430 COG1430
Uncharacterized conserved membrane protein, UPF0127 family [Function unknown];
11-153 4.82e-45

Uncharacterized conserved membrane protein, UPF0127 family [Function unknown];


Pssm-ID: 441039  Cd Length: 138  Bit Score: 144.28  E-value: 4.82e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490826380  11 MFVAFVAradeAQPMRLPVDKEQLIFITSTgnkINFALEVADTDEARVRGLMWRTDFPKDRAMIFILGEMRRIVMWMQNT 90
Cdd:COG1430    1 MLLALLL----LALAAAALPTGELTINTAG---LAIDVEVADTFEERARGLMFRKSLPEDEGMLFVFDEPRCRSFWMKNT 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490826380  91 PLPLDMVFLDDKGRVVAIHENAVPFSENLISSEVPAAYAVELLAGTVKRTGIKVGDRAIHRVI 153
Cdd:COG1430   74 RFPLDIIFLDADGRIVSIAENLPPCSWTSYPSGGPARYVLELPAGWAARLGIKVGDRLEIEPL 136
DUF192 pfam02643
Uncharacterized ACR, COG1430; Two structures have been solved for members of this large (>500 ...
 48-147 1.51e-44

Uncharacterized ACR, COG1430; Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologs are also present in several Plasmodium species). TOPSAN analysis for pdb:3pjy shows that there is much similarity with the other solved structure, pdb:3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homolog of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homolog in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. PDB:3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).


Pssm-ID: 460636  Cd Length: 104  Bit Score: 141.87  E-value: 1.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490826380   48 LEVADTDEARVRGLMWRTDFPKDRAMIFILGEMRRIVMWMQNTPLPLDMVFLDDKGRVVAIHENAVPFSENLISSEVPAA 127
Cdd:pfam02643   2 VEVADTPEERARGLMFRTSLPEDEGMLFVFDRPQPHSFWMKNTLFPLDIIFIDADGRIVAIEENVPPCSEEPCPSPGPVR 81

                          90       100
                  ....*....|....*....|
gi 490826380  128 YAVELLAGTVKRTGIKVGDR 147
Cdd:pfam02643  82 YVLELPAGWAAKLGIKVGDR 101
PRK03760 PRK03760
hypothetical protein; Provisional
 35-147 3.63e-06

hypothetical protein; Provisional


Pssm-ID: 235157  Cd Length: 117  Bit Score: 43.53  E-value: 3.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490826380  35 IFITSTGNKINFALEVADTDEARVRGLMWRTDFpkDRAMIFILGEMRRI--VMWMQNTPLPLDMVFLDDKGRVVAIhENA 112
Cdd:PRK03760   2 IINKTKGKSWHGAVRFADTFIKRFRGLMLVRNV--NYALVFILPAETRFnaSIHMFFMLSSIDVIFLDSNRRVVDF-KTL 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 490826380 113 VPFseNLISSEVPAAYAVELLAGTVKRTGIKVGDR 147
Cdd:PRK03760  79 KPW--RIYVPKKPARYIIEGPVGKIRVLKVEVGDE 111
 
Name Accession Description Interval E-value
COG1430 COG1430
Uncharacterized conserved membrane protein, UPF0127 family [Function unknown];
11-153 4.82e-45

Uncharacterized conserved membrane protein, UPF0127 family [Function unknown];


Pssm-ID: 441039  Cd Length: 138  Bit Score: 144.28  E-value: 4.82e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490826380  11 MFVAFVAradeAQPMRLPVDKEQLIFITSTgnkINFALEVADTDEARVRGLMWRTDFPKDRAMIFILGEMRRIVMWMQNT 90
Cdd:COG1430    1 MLLALLL----LALAAAALPTGELTINTAG---LAIDVEVADTFEERARGLMFRKSLPEDEGMLFVFDEPRCRSFWMKNT 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490826380  91 PLPLDMVFLDDKGRVVAIHENAVPFSENLISSEVPAAYAVELLAGTVKRTGIKVGDRAIHRVI 153
Cdd:COG1430   74 RFPLDIIFLDADGRIVSIAENLPPCSWTSYPSGGPARYVLELPAGWAARLGIKVGDRLEIEPL 136
DUF192 pfam02643
Uncharacterized ACR, COG1430; Two structures have been solved for members of this large (>500 ...
 48-147 1.51e-44

Uncharacterized ACR, COG1430; Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologs are also present in several Plasmodium species). TOPSAN analysis for pdb:3pjy shows that there is much similarity with the other solved structure, pdb:3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homolog of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homolog in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. PDB:3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).


Pssm-ID: 460636  Cd Length: 104  Bit Score: 141.87  E-value: 1.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490826380   48 LEVADTDEARVRGLMWRTDFPKDRAMIFILGEMRRIVMWMQNTPLPLDMVFLDDKGRVVAIHENAVPFSENLISSEVPAA 127
Cdd:pfam02643   2 VEVADTPEERARGLMFRTSLPEDEGMLFVFDRPQPHSFWMKNTLFPLDIIFIDADGRIVAIEENVPPCSEEPCPSPGPVR 81

                          90       100
                  ....*....|....*....|
gi 490826380  128 YAVELLAGTVKRTGIKVGDR 147
Cdd:pfam02643  82 YVLELPAGWAAKLGIKVGDR 101
PRK03760 PRK03760
hypothetical protein; Provisional
 35-147 3.63e-06

hypothetical protein; Provisional


Pssm-ID: 235157  Cd Length: 117  Bit Score: 43.53  E-value: 3.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490826380  35 IFITSTGNKINFALEVADTDEARVRGLMWRTDFpkDRAMIFILGEMRRI--VMWMQNTPLPLDMVFLDDKGRVVAIhENA 112
Cdd:PRK03760   2 IINKTKGKSWHGAVRFADTFIKRFRGLMLVRNV--NYALVFILPAETRFnaSIHMFFMLSSIDVIFLDSNRRVVDF-KTL 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 490826380 113 VPFseNLISSEVPAAYAVELLAGTVKRTGIKVGDR 147
Cdd:PRK03760  79 KPW--RIYVPKKPARYIIEGPVGKIRVLKVEVGDE 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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