|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
19-423 |
3.55e-164 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 467.77 E-value: 3.55e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 19 RVLFASLVGTTIEFFDFYIYATAAVIIFPHLFFPASSGSAAVLQSLATFAIAFIARPIGAALFGHLGDRIGRKATLVAAL 98
Cdd:cd17369 2 RVALASLVGTAIEWYDFFIYGTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 99 LTMGISTVCIGLLPTYAQIGIVAPLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFILATGSF 178
Cdd:cd17369 82 LLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 179 LLLSAAIPEQAFMQWGWRIPFIASAILVIVGLYIRLKLHETPAFQKVLDKQKEVNIPFKEVVTKHTGKLILGTIAAICTF 258
Cdd:cd17369 162 LLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAEN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 259 VVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKATSVGVCIAAAIFGLFFSSMLESGNT- 337
Cdd:cd17369 242 VLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTw 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 338 LIVFLFLCTGLSIMGLTYGPIGTVLSEIFPTSVRYTGSALTFNLAGIFGASFAPLIATKL-AETYGLYAVGYYLTAASLL 416
Cdd:cd17369 322 LIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALvAATGSWWPVALYLAALAVI 401
|
....*..
gi 490849955 417 SLVAFLL 423
Cdd:cd17369 402 SLVAALF 408
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
27-418 |
1.41e-136 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 397.41 E-value: 1.41e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 27 GTTIEFFDFYIYATAAVIIFPHLFFPASSGSAAVLQSLATFAIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTV 106
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 107 CIGLLPTYAQIGIVAPLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFILATGSFLLLSAAIP 186
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 187 EQAFMQWGWRIPFIASAILVIVGLYIRLKLHETPAFQKVLDKQKEVNIPFKEVVTKHTGKLILGTIAAICTFVVFYLTTV 266
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFYLITT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 267 FALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKATSVGVCIAAAIFG-LFFSSMLESGNTLIVFLFLC 345
Cdd:TIGR00883 241 YLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAvPLLMALLDSGSFTLFFFLVL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490849955 346 TGLSIMGLTYGPIGTVLSEIFPTSVRYTGSALTFNLAGIFGASFAPLIATKLAETYG-LYAVGYYLTAASLLSL 418
Cdd:TIGR00883 321 GMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGdWYAIGYYLAALALIGL 394
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
1-427 |
6.74e-81 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 256.20 E-value: 6.74e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 1 MESTSATAAPVVATNSKT---RVLFASLVGTTIEFFDFYIYATAAVIIFPHLFFPASSGSAAVLQSLATFAIAFIARPIG 77
Cdd:PRK09952 1 MDSTLISTRPDEGTLSLSrarRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 78 AALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQIGIVAPLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRA 157
Cdd:PRK09952 81 GVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 158 WYGMFPQLGAPIGFILATGSFLLLSAAIPEQAFMQWGWRIPFIASAILVIVGLYIRLKLHETPAF-QKVLDKQKE-VNIP 235
Cdd:PRK09952 161 FYSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFeQQQHEQAAAkKRIP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 236 FKEVVTKHTGKLILGTIAAICTFVVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKAtsv 315
Cdd:PRK09952 241 VIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRR--- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 316 gVCIAAAIFGLF----FSSMLESGNTLIVFLFlctglSIM--GLTYGPIGTV----LSEIFPTSVRYTGSALTFNLAGIF 385
Cdd:PRK09952 318 -VYITGALIGTLsafpFFMALEAQSIFWIVFF-----SIMlaNIAHDMVVCVqqpmFTEMFGASYRYSGAGVGYQVASVV 391
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 490849955 386 GASFAPLIATKLAETYG--LYAVGYYLTAASLLSLVAFLLIRET 427
Cdd:PRK09952 392 GGGFTPFIAAALVTYFGgsWHSVAIYLLAGCLISAMTALLMKDN 435
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
15-429 |
2.88e-70 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 229.98 E-value: 2.88e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 15 NSKTR-VLFASLVGTTIEFFDFYIYATAAVIIfPHLFFPASSGSAAVLQSLATFAIAFIARPIGAALFGHLGDRIGRKAT 93
Cdd:PRK10642 11 DGKLRkAITAASLGNAMEWFDFGVYGFVAYAL-GKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 94 LVAALLTMGISTVCIGLLPTYAQIGIVAPLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFIL 173
Cdd:PRK10642 90 LAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 174 ATGSFLLLSAAIPEQAFMQWGWRIPFIASAILVIVGLYIRLKLHETPAFQKVLDKQKEVN---------IPFKEVVTKHT 244
Cdd:PRK10642 170 GAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQGDreglqdgpkVSFKEIATKHW 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 245 GKLILGTIAAICTFVVFYLTTVFALNWGTTKLGYARGEFLeLQLFATLCFAAFI-PLSAIFAEKFGRKATSVGVCIAAAI 323
Cdd:PRK10642 250 RSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGV-LIIIAIMIGMLFVqPVMGLLSDRFGRRPFVILGSVALFV 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 324 FGLFFSSMLESGNTLIVFLFLCTGLSIMGLTYGPIGTVLSEIFPTSVRYTGSALTFNLAgIFGASFAPLIATKLAETYG- 402
Cdd:PRK10642 329 LAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNIS-VLVAGLTPTLAAWLVESTQn 407
|
410 420
....*....|....*....|....*..
gi 490849955 403 LYAVGYYLTAASLLSLVAFLLIRETKN 429
Cdd:PRK10642 408 LMMPAYYLMVVAVIGLITGVTMKETAN 434
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
21-428 |
5.89e-62 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 205.99 E-value: 5.89e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 21 LFASLVGTTIEFFDFYIYATAAVIiFPHLFFPASSGSAAVLQSLATFAIAFIARPIGAALFGHLGDRIGRKATLVAALLT 100
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALY-FAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 101 MGISTVCIGLLPTYAQIGIVAPLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFILATGSFLL 180
Cdd:cd17367 80 MAAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 181 LSAAIPEQAFMQWGWRIPFIASAILVIVGLYIRLKLHETPAFQKVLDKQKEVNIPFKEVVtKHTGKLILGTIAAICTFVV 260
Cdd:cd17367 160 LQHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRELR-RHPRELLLVVGLTAGGTLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 261 FYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKATSVGVCIAAAIFGLFFSSMLESGNTLIV 340
Cdd:cd17367 239 FYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYT 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 341 FLFL-CTGLSIMGLTYGPIGTVLSEIFPTSVRYTGSALTFNLA-GIFGASfAPLIATKLAETYGLYAVGYYLTAASLLSL 418
Cdd:cd17367 319 AFALvLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAvAIFGGT-APYVALWLKSIGHEWVFFWYVAGLIAISL 397
|
410
....*....|
gi 490849955 419 VAFLLIRETK 428
Cdd:cd17367 398 VVYLRMPETR 407
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
23-427 |
1.90e-60 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 201.05 E-value: 1.90e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 23 ASLVGTTIEFFDFYIYATAAVIIfPHLFFPASSGSAAVLQSLATFAIAFIARPIGAALFGHLGDRIGRKATLVAALLTMG 102
Cdd:cd17366 3 AAALGNAMEWFDFGVYGYLAVTI-GKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 103 ISTVCIGLLPTYAQIGIVAPLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFILATGSFLLLS 182
Cdd:cd17366 82 ASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 183 AAIPEQAFMQWGWRIPFIASAILVIVGLYIRlklhetpafqkvldkqkevnipfkevvtkhtGKLILGTIAAICTFVVFY 262
Cdd:cd17366 162 LLLTEAQMLDWGWRIPFLIAAPLGLVGLYLR-------------------------------RPLLICIGLVLVFNVTNY 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 263 LTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKATSVGVCIAAAIFGLFFSSMLESGNTLIVFL 342
Cdd:cd17366 211 MLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAAIFI 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 343 FLCTGLSIMGLTYGPIGTVLSEIFPTSVRYTGSALTFNLAGIFGASFAPLIATKLAETYG-LYAVGYYLTAASLLSLVAF 421
Cdd:cd17366 291 GLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGnPLMPAYYLMVAAVVGLVAV 370
|
....*.
gi 490849955 422 LLIRET 427
Cdd:cd17366 371 LFLTET 376
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
21-427 |
3.81e-59 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 198.75 E-value: 3.81e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 21 LFASLVGTTIEFFDFYIYATAAVIIfPHLFFPASSGSAAVLQSLATFAIAFIARPIGAALFGHLGDRIGRKATLVAALLT 100
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYI-GRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 101 MGISTVCIGLLPTYAQIGIVAPLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFILATGSFLL 180
Cdd:cd17368 80 MALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 181 LSAAIPEQAFMQWGWRIPFIASAILVIVGLYIRLKLHETPAFQKVLdKQKEVNIPFkEVVTKHTGKLILGTIAAICTFVV 260
Cdd:cd17368 160 LSLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERK-ARPTRRELF-ALLANNRRIILLGMLLVAGSTVT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 261 FYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKAtsVGVCIAAAIFGLFFSSML------ES 334
Cdd:cd17368 238 FYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRP--VLLVITLAALVTLYPVFAwltaapSF 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 335 GNTLIVFLFLCTglsIMGLTYGPIGTVLSEIFPTSVRYTGSALTFNLA-GIFGAsFAPLIATKLAETYG-LYAVGYYLTA 412
Cdd:cd17368 316 GRLLLVLLVLSF---FFGMYGGAMVVALVELFPVRVRSTGFSLVYALAvAIFGG-FAQFIVTWLIELTGsPLAPAWYLMG 391
|
410
....*....|....*
gi 490849955 413 ASLLSLVAFLLIRET 427
Cdd:cd17368 392 AALLGLLATLMLRET 406
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
21-420 |
3.47e-49 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 170.86 E-value: 3.47e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 21 LFASLVGTTIEFFDFYIYATAAVIIFPHLFFPASSgsaavLQSLATFAIAFIARPIGAALFGHLGDRIGRKATLVAALLT 100
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSL-----LQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 101 MGISTVCIGLLPTyaqigivaPLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFILATGSFLL 180
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 181 LSAAIPEqafmQWGWRIPFIASAILVIVGLYIRLklhetpafqkvldkqkevnipfkevvtkhtgKLILGTIAAICTFVV 260
Cdd:cd17316 148 LIPLLSG----DWGWRILFLIGALPALLALLLRR-------------------------------RTLLLILLWFFISFG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 261 FYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKATSVGVCIAAAIFGLFFSSMLESGNTLIV 340
Cdd:cd17316 193 YYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 341 FLFLCTGLsIMGLTYGPIGTVLSEIFPTSVRYTGSALTFNLAGIFGASFAPLIATKLAETYGLYAVGYYLTAASLLSLVA 420
Cdd:cd17316 273 LLLFILSF-FVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
5-424 |
3.66e-45 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 162.42 E-value: 3.66e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 5 SATAAPVVATNSKTRVLFASLVGTTIEFFDFYIYATAAVIIfPHLFFPASSGSAAVLQSLATFAIAFIARPIGAALFGHL 84
Cdd:PRK15075 1 MSTMTPAASRESKARAILRVTSGNFLEMFDFFLFGFYATAI-AKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 85 GDRIGRKATLVAALLTMGISTVCIGLLPTYAQIGIVAPLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQ 164
Cdd:PRK15075 80 IDRVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 165 LGAPIGFILATGSFLLLSAAIPEQAFMQWGWRIPFIASAILVIVGLYIRLKLHETPAFqkvldKQKEVNIPFKEVVT--- 241
Cdd:PRK15075 160 ASQQVAVVFAALLGYLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEF-----LARKHRPSMREIFRsla 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 242 KHTGKLILGTIAAICTFVVFYLTTVFALNWGTTKLGYARGEflelQLFATLCFAA--FI--PLSAIFAEKFGRKATSVGV 317
Cdd:PRK15075 235 ANWRIVLAGMLMVAMTTVSFYLITVYTPTFGKTVLHLSAAD----SLLVTLCVGVsnFIwlPIGGALSDRIGRRPVLIAF 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 318 CIAAAIFGLFFSSMLES----GNTLIVFLFLCTglsIMGLTYGPIGTVLSEIFPTSVRYTGSALTFNLA-GIFGAsFAPL 392
Cdd:PRK15075 311 TVLAILTAYPALSWLVAapsfARMLAVELWLSF---LYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLAtAIFGG-FTPA 386
|
410 420 430
....*....|....*....|....*....|...
gi 490849955 393 IATKLAETYGLYAV-GYYLTAASLLSLVAFLLI 424
Cdd:PRK15075 387 ISTWLIHVTGDKAApGYWLSFAAVCGLIATLVL 419
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
2-430 |
3.12e-37 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 140.71 E-value: 3.12e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 2 ESTSATAAPVVATNSKTRV--LFASLVGTTIEFFDFYIYATAAvIIFPHLFFPASSGSAAVLQSLATFAIAFIARPIGAA 79
Cdd:PRK10406 3 ESTVTADSKLTSSDTRRRIwaIVGASSGNLVEWFDFYVYSFCS-LYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 80 LFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQIGIVAPLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWY 159
Cdd:PRK10406 82 LFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 160 GMFPQLGAPIGFILATGSFLLLSAAIPEQAFMQWGWRIPFIASAILVIVGLYIRLKLHETPafQKVLDKQKEVNIPFKEV 239
Cdd:PRK10406 162 ASFQYVTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETS--QQETRALKEAGSLKGLW 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 240 VTKHTGKLILGTIAAicTFVVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKATSVGVCI 319
Cdd:PRK10406 240 RNRRAFIMVLGFTAA--GSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGS 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 320 AAAIFGLFFSSMLES-GNTLIVFLFLCTGLSIMGLTYGPIGTVLSEIFPTSVRYTGSALTFNLA-GIFGASfAPLIATKL 397
Cdd:PRK10406 318 LAALFTVPILSALQNvSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVAnALFGGS-AEYVALSL 396
|
410 420 430
....*....|....*....|....*....|....
gi 490849955 398 AETYGLYAVGYYLTAASLLS-LVAFLLIRETKNE 430
Cdd:PRK10406 397 KSIGMETAFFWYVTLMAVVAfLVSLMLHRKGKGM 430
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
21-427 |
4.26e-24 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 103.15 E-value: 4.26e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 21 LFASLVGTTIEFFDFYIYATAAVIIFPHlfFPASSGSAAVLQSLATFAIAfiarpIGAALFGHLGDRIGRKATLVAALLT 100
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAE--FGLDEAEAGLLGTVTLAGGA-----IGGILGGILADRFGRVRVLVITILL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 101 MGISTVCIGLLPTYAQigivapllLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFILATGSFLL 180
Cdd:cd17371 74 FAVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAAL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 181 LSAAIPEqafmQWGWRIPFIASAILVIVGLYIRLKLHETPAFQKVLDKQKEVNIPFKEVVTKHTGKL---ILGTIAAICT 257
Cdd:cd17371 146 LFPLLPP----EIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLrttLLASLLATGA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 258 FVVFYLTTVFALNWGTTKLGYA-RGEFLELQLFATLCFAAFIpLSAIFAEKFGRKATSVGVCIAAAIFgLFFSSMLESGN 336
Cdd:cd17371 222 LGGYYGITTWLPSYLTGERGLSfEGSAGYLVVTILGGFLGYL-AGGFLADRIGRRNNFALFALGSAIS-ILLYFFLPLSP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 337 TLIVFLFLCTGLSIMGLtYGPIGTVLSEIFPTSVRYTGSALTFNLAGIFGASFaPLIATKLAETYGL-YAVGYYLTAASL 415
Cdd:cd17371 300 TLILILGFPLGFFASGP-FSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALF-PFLVGFLATSGSLgTAIAVFAAVYYI 377
|
410
....*....|..
gi 490849955 416 LSLVAFLLIRET 427
Cdd:cd17371 378 AGLVLALLLPET 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-425 |
7.19e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 101.87 E-value: 7.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 19 RVLFASLVGTTIEFFDFYIYATAAVIIFPHLFFPASSGSAAvlqslatFAIAFIARPIGAALFGHLGDRIGRKATLVAAL 98
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLL-------ASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 99 LTMGISTVCIGLLPTYAQigivapllLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFILATGSF 178
Cdd:COG2271 83 LLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 179 LLLSAAipeqafmqWGWRIPFIASAILVIVGLYIRlklhetpafqkvldkqkevnipfkevvtkhtgkLILGTIAAICTF 258
Cdd:COG2271 155 GWLLAA--------FGWRAAFLILGLPGLLLALLR---------------------------------FWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 259 VVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRK-ATSVGVCIAAAIFGLFFSSMLESGNT 337
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALALLLLALLPSPAL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 338 LIVFLFLCTGLsiMGLTYGPIGTVLSEIFPTSVRYTGSALTfNLAGIFGASFAPLIATKLAETYGLYAVGYYLTAASLLS 417
Cdd:COG2271 274 AIALLFLAGFG--LGGAFGLLWALAAELFPKKARGTASGLV-NTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLA 350
|
....*...
gi 490849955 418 LVAFLLIR 425
Cdd:COG2271 351 ALLALLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
15-428 |
8.13e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 99.57 E-value: 8.13e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 15 NSKTRVLFASLVGTTIEFFDFYIYATAAVIIFPHLFFPASsgsaavlQSLATFAIAFIARPIGAALFGHLGDRIGRKATL 94
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAA-------QLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 95 VAALLTMGISTVCIGLLPTYAQigivapllLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFILA 174
Cdd:COG2223 74 LIGLLLLGIGLLLLALAVSYWL--------LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 175 TGSFLLLSAAipeqafmqWGWRIPF-IASAILVIVGLYIRLKLHETPAFQKVldKQKEVNIPFKEVVTkhTGKLILGTIA 253
Cdd:COG2223 146 AFLAPLLIAA--------FGWRNAFlILGILLLVVAVLAWLFLRDPPAGAAA--AAKASLRDQLEALR--DPRFWLLSLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 254 AICTFVVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKATSVGVCIAAAIFGLFFSSMLE 333
Cdd:COG2223 214 YFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 334 SGNTLIVFLFLCTGLsiMGLTYGPIGTVLSEIFPTSVRYTGSALTFnLAGIFGASFAPLIATKLAETYGLYAVGYYLTAA 413
Cdd:COG2223 294 SLWLFLVLFLLLGLA--LGGGNGAVFALVPDIFPTKNAGAVYGLVG-AAGGLGGFLGPLLFGALLDATGSYTAAFLVFAV 370
|
410
....*....|....*.
gi 490849955 414 -SLLSLVAFLLIRETK 428
Cdd:COG2223 371 lALVALVLTLLLYRRP 386
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-305 |
2.07e-20 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 91.03 E-value: 2.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 7 TAAPVVATNSKTRVLFASLVGTTIEFFDFYIYATAAVIIFPHLffpassgSAAVLQSLATFAIAFIARPIGAALFGHLGD 86
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADL-------GASSAQLGWIVSAYLLGRAIGLLLFGRLGD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 87 RIGRKATLVAALLTMGISTVCIGLLPTyaqigivaPLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLG 166
Cdd:COG0477 75 RYGRKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 167 APIGFILATGSFLLLSAAipeqafmqWGWRIPFIASAILVIVGLYIRLKLHETPAFQKVLDKQKEVNIPFKEVVTKHTGK 246
Cdd:COG0477 147 IGLGLALGPLLGGLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLAL 218
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 490849955 247 LILGTIAAICTFVVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFA 305
Cdd:COG0477 219 LLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLA 277
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
26-429 |
4.06e-19 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 89.25 E-value: 4.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 26 VGTTIEFFDFYIYATAAVIIFPHLFFPA----SSGSAAVLQSLATFAIAFIARPIGAALFGHLGDRIGRKATLVAALLTM 101
Cdd:pfam00083 7 LGGFLFGYDTGVIGAFLTLIDFFKNFGLsksvSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 102 GISTVCIGLLPTYAqigivAPLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFILATGSFLLL 181
Cdd:pfam00083 87 VIGAVLQGAAKGKW-----SVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 182 SAAIPEqafmqWGWRIPFIASAILVIVGLYIRLKLHETPAFQ-------------KVLDKQKEVNIPFKEVVTKHTGKLI 248
Cdd:pfam00083 162 NKTSNS-----DGWRIPLGLQLVPALLLIIGLLFLPESPRWLvekgrleearevlAKLRGVPDVDRELDEIKDSLEAGQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 249 LGTIAAICTF----VVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCF--------------AAFIPLSAIFAEKFGR 310
Cdd:pfam00083 237 AEKASWKELFstktRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLsdsflvtiivgvvnFVFTFIAIFLVDRFGR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 311 KAT--------SVGVCIAAAIFGLFFSSMLESGNTLIVFLFLctGLSIMGLTYGPIGTVL-SEIFPTSVRYTGSALTFNL 381
Cdd:pfam00083 317 RPLlllgaagmAICFVILGIVALLGVSKSDWAGIVAIVFIAL--FIAFFAMGWGPVPWVIvSELFPLSVRSKAMALATAA 394
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 490849955 382 AGIFGAsFAPLIATKLAETYGLYAVGYYLTAASLLS-LVAFLLIRETKN 429
Cdd:pfam00083 395 NWLANF-LIGFLFPIITDAIGLGYTFFIFAGLLVLFiIFVFFFVPETKG 442
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-387 |
4.58e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 81.94 E-value: 4.58e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 13 ATNSKTRVLFASLVGTTIEFFDFYIYATAAVIIFPHLFFPASSGSAAVlqslatfAIAFIARPIGAALFGHLGDRIGRKA 92
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVV-------TAYLLGAALGAPLAGRLADRFGRRR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 93 TLVAALLTMGISTVCIGLLPTYAqigivaplLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFI 172
Cdd:COG2814 77 VLLLGLLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 173 LATGSFLLLSAAipeqafmqWGWRIPFIASAIL-VIVGLYIRLKLHETPAFQKVLDKQKEVNIpfkevvtKHTGKLILGT 251
Cdd:COG2814 149 LGPLLGGLLADL--------FGWRWVFLVNAVLaLLALLLLLRLLPESRPAARARLRGSLREL-------LRRPRLLLLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 252 IAAICTFVVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKATsVGVCIAAAIFGLFFSSM 331
Cdd:COG2814 214 LLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL-LLIGLLLLALGLLLLAL 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 490849955 332 LESGNTLIVFLFLCTGLsiMGLTYGPIGTVLSEIFPTSVRYTGSALTFNLAGIFGA 387
Cdd:COG2814 293 AGSLWLLLLALFLLGFG--FGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
14-421 |
4.83e-17 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 82.67 E-value: 4.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 14 TNSKTRVLFASLVGTTIEFFDFyiyataaVIIFPHLFFPASSGSAAVLQSLATFAIAFIARPIGAALFGHLGDRIGRKAT 93
Cdd:PRK12307 13 TRPQKNALFSAWLGYVFDGFDF-------MLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 94 LVAALLTMGISTVCIGLLPTYaqigivapLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFIL 173
Cdd:PRK12307 86 MMWSIVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNII 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 174 AtgsflllsAAIPEQAFMQWGWRIPFIASAILVIVGLYIRLKLHETPAFQKVLDKQKEVNIPFKEVVTKHTGKLILGTIA 253
Cdd:PRK12307 158 A--------AYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRAQ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 254 AICTFVVF-YLTTVFALNWGTTKL--GYARGEFLELQLFATLCFAAFIP--LSAIF----AEKFG-RKATSVGVCIA-AA 322
Cdd:PRK12307 230 FPLTLCVFiVLFSIFGANWPIFGLlpTYLAGEGFDTGVVSNLMTAAAFGtvLGNIVwglcADRIGlKKTFSIGLLMSfLF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 323 IFGLFFSSMLESGNT-LIVFLFLCTGLSIMGLtygpIGTVLSEIFPTSVRYTGSALTFNLAGIfGASFAPLIATKLAETY 401
Cdd:PRK12307 310 IFPLFRIPQDNYLLLgACLFGLMATNVGVGGL----VPKFLYDYFPLEVRGLGTGLIYNLAAT-SGTFNSMAATWLGITM 384
|
410 420
....*....|....*....|...
gi 490849955 402 GLYAVGYYLTA---ASLLSLVAF 421
Cdd:PRK12307 385 GLGAALTFIVAfwtATILLIIGL 407
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
44-425 |
3.43e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.46 E-value: 3.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 44 IIFPHLFFPASSGSAAVLQSLATFAIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQigivapl 123
Cdd:cd17325 14 IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ------- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 124 lLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRA----WYGMFPQLGAPIGFILatGSFLllsaaipeqaFMQWGWRIPF 199
Cdd:cd17325 87 -LLLARFLQGLASAAVWPAAMALIADIAPPEERGramgIFSSAIGLGFLIGPLL--GGLL----------ADALGYRAPF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 200 IASAILVIVGLYIRL-KLHETPAFQKVLDKQKEVNIPFKEVVTKHTGKLILGTIAAICTFVVFYLTTVFALnWGTTKLGY 278
Cdd:cd17325 154 LVCAALALLALVLALlLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPL-YAAELGGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 279 ARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKATSVGVCIAAAIFGLFFSSMleSGNTLIVFLFLCTGLSiMGLTYGPI 358
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA--TSFWLLLLLLALLGLG-LGLVFPAT 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490849955 359 GTVLSEIFPTSVRYTGSALtFNLAGIFGASFAPLIATKLAETYGLYAVGYYLTAASLLSLVAFLLIR 425
Cdd:cd17325 310 LALLADIVPPEGRGTAMGL-FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
67-398 |
1.29e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 59.68 E-value: 1.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 67 FAIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQigivapllLAVCRLGQGLGLGGEWSGAVLL 146
Cdd:TIGR00895 58 FSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNAL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 147 ATENAPEGKRAWYGMFPQLGAPIGFILATgsfLLLSAAIPeqafmQWGWRIPF-IASAILVIVGLYIRLKLHETPAFQKV 225
Cdd:TIGR00895 130 VSEYAPKRFRGTAVGLMFCGYPIGAAVGG---FLAGWLIP-----VFGWRSLFyVGGIAPLLLLLLLMRFLPESIDFLVS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 226 LDKQKEVNIPFKEVVTKH-------------------------TGKLILGTIAAICTFVVFYLTTVFALNWgTTKLGYAR 280
Cdd:TIGR00895 202 KRPETVRRIVNAIAPQMQaeaqsalpeqkstqgtkrsvfkalfQGKTARITVLLWLLYFMLLVGVYFLTNW-LPKLMVEL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 281 GEFLELQLFATLCFAAFIPLSAIF----AEKFGRKATSVGVCIAAAIFGLFFSSmlESGNTLIVFLFLCTGLSIMGlTYG 356
Cdd:TIGR00895 281 GFSLSLAATGGALFNFGGVIGSIIfgwlADRLGPRVTALLLLLGAVFAVLVGST--LFSPTLLLLLGAIAGFFVNG-GQS 357
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 490849955 357 PIGTVLSEIFPTSVRYTGSALTFNLaGIFGASFAPLIATKLA 398
Cdd:TIGR00895 358 GLYALMALFYPTAIRATGVGWAIGI-GRLGAIIGPILAGYLL 398
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
19-425 |
1.36e-09 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 59.71 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 19 RVLFASLVGTTIEFFDFYIYATAAVIIfphlffpASSGSAAVLQSLATFAIAFIARPIGAALFGHLGDRIGRKATLVAAL 98
Cdd:PRK03893 20 KAFSAAWLGYLLDGFDFVLITLVLTEV-------QGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 99 LTMGISTVCIGLLPTYAqigivaplLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFILATGSF 178
Cdd:PRK03893 93 VLFSVGTLACGFAPGYW--------TLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 179 LLLSAAipeqafmqWGWRIPFIASAILVIVGLYIRLKLHETPAFQKVLDKQKEV---------------NIP-------- 235
Cdd:PRK03893 165 SLVVPV--------WGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKAPVrtmvdilyrgehriiNILltlaaaaa 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 236 ----FKEVVTKHTGKLILGTIAAIC--------------TFVVFYLTTVFAL-----------NWGTTKLGYARGEFLEL 286
Cdd:PRK03893 237 lwfcFAGNLQNAAIVAVLGLLCAAIfisfmvqssgkrwpTGVMLMVVVLFAFlyswpiqallpTYLKTDLGYDPHTVANV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 287 QLFATLCFAAFIPLSAIFAEKFG-RKATSVGVCIAAA-IFGLFFssmLESGNTLIVFLFL----CTGLSIMGLtygpIGT 360
Cdd:PRK03893 317 LFFSGFGAAVGCCVGGFLGDWLGtRKAYVCSLLISQLlIIPVFA---IGGANVWVLGLLLffqqMLGQGISGL----LPK 389
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490849955 361 VLSEIFPTSVRYTGSALTFNLaGIFGASFAPLIATKLAETYGLyavGYYLTAASL-LSLVAFLLIR 425
Cdd:PRK03893 390 LIGGYFDTEQRAAGLGFTYNV-GALGGALAPILGALIAQRLDL---GTALASLSFsLTFVVILLIG 451
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
67-391 |
2.39e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.58 E-value: 2.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 67 FAIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYaqigivapLLLAVCRLGQGLGLGGEWSGAVLL 146
Cdd:pfam07690 38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL--------WLLLVLRVLQGLGAGALFPAALAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 147 ATENAPEGKR----AWYGMFPQLGAPIGFILATGsflllsaaipeqAFMQWGWRIPFIASAILVIVGLYIRLkLHETPAF 222
Cdd:pfam07690 110 IADWFPPEERgralGLVSAGFGLGAALGPLLGGL------------LASLFGWRAAFLILAILSLLAAVLLL-LPRPPPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 223 QKVLDKQKEVNIPFKEVVTKHTGKLILGTIAAICTFVVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSA 302
Cdd:pfam07690 177 SKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 303 IFAEKFGRKATSVGVCIAAAIFGLFFSSMLESGNTLIVFLFLCTGLSIMGLTYGPIGTVLSEIFPTSVRYTGSALtFNLA 382
Cdd:pfam07690 257 RLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL-YNTA 335
|
....*....
gi 490849955 383 GIFGASFAP 391
Cdd:pfam07690 336 GSLGGALGP 344
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
76-428 |
5.28e-09 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 58.10 E-value: 5.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 76 IGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAqigivaplLLAVCRLGQGLGLGGEWSGAVLLATENAPEGK 155
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYT--------VFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 156 RAWYGMFPQLGAPIGFILatgsFLLLSAAIPEqafmqwgWRIPFIASAILVIVGLYIRLKLHETPAF----------QKV 225
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLVL----LPLVAYFIPD-------WRWLQLAVSLPTFLFFLLSWFVPESPRWlisqgrieeaLKI 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 226 LDKQKEVN---IP---FKEVVTKH--TGKLILGTIAAICTFVVFYLTTVFALNWGTTKLGY----ARGEFLELQLFATLC 293
Cdd:TIGR00898 283 LQRIAKINgkkLPaevLSLSLEKDlsSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYyglvLDLGNLGGNIYLDLF 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 294 FAAFIPLSAIFA-----EKFGRKATSVGVCIAAAIFGL---FFSSMLESGNTLIVFL--FLCTGLSIMGLTYGPigtvls 363
Cdd:TIGR00898 363 ISGLVELPAKLItllliDRLGRRYTMAASLLLAGVALLlllFVPVDLYFLRTALAVLgkFGITSAFQMVYLYTA------ 436
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490849955 364 EIFPTSVRYTGSALTfNLAGIFGASFAPLIAtKLAETYGLYAVGYYLTAASLLSLVAFLLIRETK 428
Cdd:TIGR00898 437 ELYPTVVRNLGVGVC-STMARVGSIISPFLV-YLGEKWLFLPLVLFGGLALLAGILTLFLPETKG 499
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
71-423 |
4.90e-08 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 54.67 E-value: 4.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 71 FIARPIGAALFGHLGD-RIGRKATLVAALLTMGISTVCIGLLPTYaqigivapLLLAVCRLGQGLGLGGEWSGAVLLATE 149
Cdd:cd17378 43 FVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNY--------WVYAFLRFLTGFGRSGIGTCALVLATE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 150 NAPEGKRAWYGMFPQLGAPIGFILATGSFLLLSAAipeqafmqwgWRIPFIASAI-----LVIVGLYIRlklhetpafqk 224
Cdd:cd17378 115 PVGPKWRGQVGMSTFFFFVLGFMSLPGIAYLNGSS----------WRVLYFWTSIpaliyCILVYLFAR----------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 225 vldkqkevnipfkevvtkhtgKLILGTIAAICTFVVFYLTTVFALNWGTTKlgyargeFLELQLFATLCFAAFIPlSAIF 304
Cdd:cd17378 174 ---------------------RLLAVMVIGFGIGMVYYGIPLAVGNLKFNI-------YLSVALNALSELPAFVI-TAFL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 305 AEKFGRKATSVGVCIAAAIFGLFFSSMLESGNTLIVFLFLCTGLSIMGLTYGPIGTVLSEIFPTSVRYTGSALtFNLAGI 384
Cdd:cd17378 225 LDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGM-LRQALV 303
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 490849955 385 FGASFAPLIATKLAE----TYGLYAVgyyltAASLLSLVAFLL 423
Cdd:cd17378 304 VGGIFAPFIVSLGRKnaalSFGVFGV-----AILLLGLFALGL 341
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
32-422 |
9.11e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 53.97 E-value: 9.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 32 FFDFYIYATAAVIIFPHLFFPASSGSAAVLQSLATFAIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLL 111
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 112 PTYaqigivapLLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGMFPQLGAPIGFILATGSFLLLSAAIpeqafm 191
Cdd:cd06174 82 PSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL------ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 192 QWGWRIPFIASAILVIVGLYIRLKLHETPAFQKVLDKQKEVNIPFKEVVTK--HTGKLILGTIAAICTFVVFYLTTVFAL 269
Cdd:cd06174 148 GFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRvlKNPGLWLLLLAIFLVNLAYYSFSTLLP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 270 NWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKATSVGVCIAAAIFGLFFSSMLESGNTLIVFLFLCtgLS 349
Cdd:cd06174 228 LFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLL--GF 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490849955 350 IMGLTYGPIGTVLSEIFPTSVRYTGSALTFNLAGIFGASFAPLIATKLAETYGLYAVGYYLTAASLLSLVAFL 422
Cdd:cd06174 306 GLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
68-428 |
4.61e-07 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 51.51 E-value: 4.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 68 AIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQIGIVAplLLAVCRLGQGLGLGGEWSGAVLLA 147
Cdd:cd17364 46 AAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIM 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 148 TENApegKRAWYGMFPQL-GAPIGF-ILATGSFLLLSAAIPEQAF-------MQWGWRIPFIASAILVIVGLYIRLKLHE 218
Cdd:cd17364 124 SEYA---NKKRRGALIAAvFAMQGFgILAGAIVTLILSAIFEHPLpagtyhhADLVWRIVLGLGAIPALSVLYFRKHLLG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 219 TPAFQKVLDkqkevnIPFkevvtkHTGKLILGTIAAictfVVFYLTTVFAlnwgtTKLGYARGEFlelQLFATLCFAafI 298
Cdd:cd17364 201 TAGTWFLLD------IAF------YGQNLFQSTIIS----AIGFSKTMNA-----YQELFNIAVG---QLIIALAGT--V 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 299 P---LSAIFAEKFGRKATSVGVCIAAAIFGLFFSSMLESGNTLIVFLFLCTGLSIMGLTYGP---IGTVLSEIFPTSVRY 372
Cdd:cd17364 255 PgywFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYDHWKISTIGFFVLYGLTFFFSNFGPnttTFIVPAEVFPARVRS 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 490849955 373 TGSALTfNLAGIFGASFAPLIATKLAETYGLYAVGYYLTAASLLSLVAFLLIRETK 428
Cdd:cd17364 335 TCHGIS-AASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTLLFPEEK 389
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
80-424 |
7.30e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.03 E-value: 7.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 80 LFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQI-------GIVAPLLLAVcrlgqglglggewsgAVLLATENAP 152
Cdd:cd17474 53 VAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLlagralqGIGAAGLGPL---------------ALTLIGDLFE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 153 EGKRAWYGMFpqLGAPIGfiLATGSFLLLSAAIPEqafmqWGWRIPFIASAILVIVGLYIRLKLHETPAFQKVLDKQKEV 232
Cdd:cd17474 118 GGERAKAMGL--YEAALG--LGIAVGPLLGGLLAA-----ISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 233 NIPFKevvtKHTGKLILGTIAAICTFVVFYLTTVFALNWGTTKLGYARGEFLELQLFA-TLCFAAFIPLSAIFAEKFGRK 311
Cdd:cd17474 189 RDLKK----ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGwSVLLALGSLFVGRLLKKRFGA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 312 ATSvgVCIAAAIFGLFFSSMLESGNTLIVFLFLCTGLSIMGLTYGPIGTVLSEIFPTSVRYTGSALtFNLAGIFGASFAP 391
Cdd:cd17474 265 RRI--LVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL-YNFVRFLGQAVGP 341
|
330 340 350
....*....|....*....|....*....|...
gi 490849955 392 LIATKLAETYGLYAVGYYLTAASLLSLVAFLLI 424
Cdd:cd17474 342 LLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
66-394 |
1.94e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 49.50 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 66 TFAIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYaQIGIVAPLLLAVCRLGQglglggeWSGAVL 145
Cdd:cd17317 30 VQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSY-ELFLVLRFLVGVTSAGI-------FTVGFV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 146 LATENAPEGKRAWYGMFPQLGAPIGFILatgsFLLLSAAIPEqafmqwgWRIPFIASAILVIVGLYIRLKLHetpafqkv 225
Cdd:cd17317 102 LGMEIVGPKYRSFVGILFGLFWALGYML----LALLAYLIRD-------WRWLQLAISLPGLLFLLLLWWLP-------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 226 ldkqkevnipfkevvtkhtGKLILGTIAAICTFVVFYLTTVFALNWGTtklgyargeflelQLFATLCFAAFIPLSAIFA 305
Cdd:cd17317 163 -------------------RRTIIVGLIWFVTSLVYYGLSLNSSNLGG-------------NLYLNFFLSGLVEIPAYFL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 306 -----EKFGRKATSVGVCIAAAIFGLFFSSMLESGNTLIVfLFLCTGLSIMGLTYGPIGTVLSEIFPTSVRYTGSALTfN 380
Cdd:cd17317 211 allllDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLAL-TLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLC-S 288
|
330
....*....|....
gi 490849955 381 LAGIFGASFAPLIA 394
Cdd:cd17317 289 TVARVGAILAPFIV 302
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
61-393 |
8.85e-06 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 47.29 E-value: 8.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 61 LQSLATFaIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYaqigivapLLLAVCRLGQGLGLGGEW 140
Cdd:cd17374 36 LKSVAQS-IFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTF--------PVYCVLRFLAGFAVSGIS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 141 SGAVLLATENAPEGKRAWYGMFPQLGAPIGFILATGsfllLSAAIPEqafmqwgWRIPFIASAILVIVG-LYIRlklhet 219
Cdd:cd17374 107 INTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAG----LAYAIRD-------WRLLQLVVSVPFFLFfLYSW------ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 220 pafqkvldkqkevnipfkevvtkhtgklILGTIAAICTFVVFYLT-TVFALNWGTTKLGyargefLELQLFATLCFAAFI 298
Cdd:cd17374 170 ----------------------------WLPKRTLILSFVWFANSfSYYGLSLDLQHLG------LNVFLLQFLFGAVEV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 299 P--LSAIFA-EKFGRKATS------VGVCIAAAIFglffssmLESGNTLIVFLFLCTGLSIMGLTYGPIGTVLSEIFPTS 369
Cdd:cd17374 216 ParCLALFLlNHMGRRISQavllllAGLCILANIF-------VPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTV 288
|
330 340
....*....|....*....|....
gi 490849955 370 VRYTGSALTfNLAGIFGASFAPLI 393
Cdd:cd17374 289 LRQTGMGLN-SMFARIGGILAPLI 311
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-422 |
2.08e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.40 E-value: 2.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 34 DFYIYATAAVIIFPHLFFPASSGSAAVLqSLATFAIAFIARPigaaLFGHLGDRIGRKATLVAALLTMGISTVCIGLLPT 113
Cdd:cd17478 9 DFYQGFLPALLPLLIAKLGLSYAQAGLL-VSVFSITSSLLQP----LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 114 YAQIGIVApLLLAVCrlgqglGLGGEWSGAVLLAteNAPEGKRAWYGMFPQLGAPIGFILATgsfLLLSAAIPEQAFMQW 193
Cdd:cd17478 84 YWLLLLLV-ALAGIG------SAAFHPEGARLAS--QAAGGRRGLAMSIFSVGGNLGFALGP---LIAAALVALFGGLGL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 194 GWRIPFIASAILVIVGLYIRLKLHEtpafqkvlDKQKEVNIPFKEVVTKHTGKLILGTIAAIC---------TFVVFYLT 264
Cdd:cd17478 152 LILLIIPGLAVALLLLRLRPLKKPE--------AKKAAAKSSARSTLKGVWRALLLLLIIVFLrswvlssltTFLPFYLV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 265 TVFALNWGTtklgyarGEFLELQLFATlcfAAFIPLSAIFAEKFGRKATSVGVCIAAAIFGLFFssmLESGNTLIVFLFL 344
Cdd:cd17478 224 QRGYSLVFA-------GLLLSLFLFAG---AIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF---LLTPGIWSYILLV 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490849955 345 CTGLSIMGlTYGPIGTVLSEIFPTSVRyTGSALTFNLAGIFGASFAPLIAtKLAETYGLYAVGYYLTAASLLSLVAFL 422
Cdd:cd17478 291 LAGFLLFA-SFPVTVVLAQELLPGNVG-LASGLMMGLSFGLGGIGAPVLG-ALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-425 |
2.15e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.41 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 50 FFPASSGSAAVLQSLATFAIAfiarpIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQIgIVAPLLLAVCR 129
Cdd:cd17473 29 FVPNSELLVPLLLTLPALFIA-----LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL-LASRALLGIGV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 130 LGQGlglggewSGAVLLATENAPEGKR----AWYGMFPQLGApIGFILATGsflllsaaipeqAFMQWGWRIPFIASAIL 205
Cdd:cd17473 103 AGIM-------TLATALIGDYFEGEERakmlGLQSAAMSLGG-VVFLLLGG------------ALAEIGWRAPFLVYLLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 206 VIVGLYIRLKLHETPAfqkvlDKQKEVNIPFKEVVTKHTGKLILGTIAAICTFVVFYLTTVF-ALNWGTTKLGYARGEFL 284
Cdd:cd17473 163 LPVLILVLLFLPEPAR-----KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQlPFLLQERGGGSAALIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 285 ELQLFATLCFAAFIPLSAIFAEKFGRKATSVGVCIAAAIFGLFFSSmleSGNTLIVFLFLCTGLSiMGLTYGPIGTVLSE 364
Cdd:cd17473 238 ALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA---SGLWVVLLGAILAGLG-FGLLLPTLNSWAMS 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490849955 365 IFPTSVRYTGSALtFNLAGIFGASFAPLIATKLAETYGLYAVGYYLTAASLLSLVAFLLIR 425
Cdd:cd17473 314 LVPPELRGRAMGI-VTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
80-424 |
3.75e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 45.69 E-value: 3.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 80 LFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQIgIVAPLLLAVcrlgqglglgGEWSGAVLLAT---ENAPEGKR 156
Cdd:cd17328 53 IFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQL-LLFRALVGI----------GEASYSPIAPTiiaDLFPKEKR 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 157 ----AWYGMFPQLGAPIGFILATgsflLLSAAIPeqafmqwGWRIPFIASAIL-VIVGLYIRLKLHETP---AFQKVLDK 228
Cdd:cd17328 122 tralGVFYFAIPLGSGLGYVVGG----LVAQATG-------GWRWAFRVTGVLgVLLAILLLLFVREPPrgaAEGGVMAK 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 229 QKEVNIP--FKEVVTKHTgkLILGTIAAICTFVVFYLTTVFALN--WGTTKLGYARGEFLELQLFATLCFAAFI--PLSA 302
Cdd:cd17328 191 STATSFLadLKALAKNPS--FILSTLGFTAVSFVTGALAFWAPTffLRAFGVGDLSSADVGLIFGAITCIAGVLgvLLGG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 303 IFAEKFGRK-----ATSVGVCIAAAIFGLFFSSMLESGNTLIVFLFLCTGLSIMGLTYGPIGTVLSEIFPTSVRYTGSAL 377
Cdd:cd17328 269 ILADRLRRKtpradPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAI 348
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 490849955 378 TFNLAGIFGASFAP----LIATKLAETYGLYAVGYYLTAASLLSLVAFLLI 424
Cdd:cd17328 349 QILLSHLLGDAGSPyligLISDLLRQNKDSPLAEAASLQYALLLCSFVLVL 399
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
68-419 |
4.09e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 45.64 E-value: 4.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 68 AIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQigivapllLAVCRLGQGLGLGGEWSGAVLLA 147
Cdd:cd17315 41 SSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 148 TENAPEGKRAWYGMFPQLGAPIGFILATGSFLLLSAAIPeqafmqWGWRIPFIASAILVIVGLYIRLKLHETPAfqkvld 227
Cdd:cd17315 113 SEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPP------GWWRLMFALAAVPALLQLLLMFFLPESRA------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 228 kqkevnipfkevvtkhtgkLILGtiAAICTF--------VVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCfaafip 299
Cdd:cd17315 181 -------------------LLVG--VGLQLLqqltginaVMYYAPTIFKSAGGGTASILASIIVGVVNLLATLV------ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 300 lSAIFAEKFGRK----ATSVGVCIAAAIFGLFFS-SMLESGNTLIVFLFLCTGLSIMGLTYGPIGTVL-SEIFPTSVRYT 373
Cdd:cd17315 234 -AIRLVDKVGRRplllIGFAGMAASLLLLAIAFLlPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLlSEIFPLRIRGK 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 490849955 374 GSALTFNLAGIFGA--SFAPLIATklaETYGLYAVGYYLTAASLLSLV 419
Cdd:cd17315 313 GMAIATLVNWIFNFivGLTFLIMV---STIGLAGVFIFFAAVCLLALV 357
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
76-422 |
4.10e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.62 E-value: 4.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 76 IGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAqigivaplLLAVCRLGQGLGLGGEWSGAVLLATENAPEGK 155
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 156 RAWYGMFPQLGAPIGFILAtgsfLLLSAAIPEqafmQWGWRIPFIASAILVIVGLYIRLKLheTPAFQKVLDKQKEVNIP 235
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLG----RPLGGLLGQ----LLGWRAAFLAIAVLALLAALLLWRL--LPSLPPKKPGSLGLLSS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 236 FKEVVTKHTGKLILGTIA-------AICTFVVFYLTTVFalnwgttklgYARGEFLELQLFAT-LCFAAFIPLSAIFAEK 307
Cdd:cd17324 191 LLLLLRNPRLRLAYLITFllfggffALYTYLAPFLTDVP----------GFSSSAIIGLLLLFgVAGVVGSPLAGRLADR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 308 FGRKATSVGVCIAAAIFGLFFSsmlesgnTLIVFLFLCTGLSIMGLTYGPIGTVL-SEIFPTSVRYTGSALTFNLAGIF- 385
Cdd:cd17324 261 GGRRALLIALLLLAAALLLLTL-------LGPSPLLLLVGLVLWGLGFFAAHSALqTRVLRLAPEARGLASSLYLAAYNl 333
|
330 340 350
....*....|....*....|....*....|....*..
gi 490849955 386 GASFAPLIATKLAETYGLYAVGYYLTAASLLSLVAFL 422
Cdd:cd17324 334 GGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
67-425 |
5.95e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.88 E-value: 5.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 67 FAIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTyaqigivaPLLLAVCRLGQGLGLGGEWSGAVLL 146
Cdd:cd17365 40 GSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--------VLQLALLRFLTGLGLGAAMPNAITL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 147 ATENAPEGKRAWYGMFPQLGAPIGFILATgsfLLLSAAIPeqafmQWGWRIPFIASAILVIVGLyirlklhetpafqkvl 226
Cdd:cd17365 112 VSEYAPARRRSLAVTLMFCGYPLGAALGG---FLAAALIP-----AFGWRSVFLLGGVPPLILL---------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 227 dkqkevnipfkevvtkhtgKLILGTIAAICTFVVFYLTTVFALNWGTTKL---GYARGEFLELQLFATLCFAAFIPLSAI 303
Cdd:cd17365 168 -------------------PLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMveaGYSLSQALTITLLLNIGGVIGSLLLGW 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 304 FAEKFGRKATSVGVCIAAAIFGLFFSSMLESGNTLIVFLFlCTGLSIMGlTYGPIGTVLSEIFPTSVRYTGSAlTFNLAG 383
Cdd:cd17365 229 LADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVF-LAGACVNG-AQVGLYALAARFYPTEVRATGVG-WALGVG 305
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 490849955 384 IFGASFAPLIATKL-AETYGLYAVGYYLTAASLLSLVAFLLIR 425
Cdd:cd17365 306 RLGAILGPLLGGLLlAAGLGPESVFLALAIPAALGALAVLLLR 348
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-413 |
5.98e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 5.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 21 LFASLVGTTIEFFDFYIYATAAVIifphlffpaSSGSAAVLQSLATFAIAFIaRPIGAALFGHLGDRIG-RKATLVAALL 99
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVLGL---------SAALVGLILLVARLWDAIT-DPLIGALSDRTRTRWGrRRPWILIGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 100 TMGISTVCIGLLPTYAQIGIVAplLLAVCRLGQGLGLGGEWSGAVLLATENAPEGK-RAWYGMFPQLGAPIGFILATGSF 178
Cdd:COG2211 90 PLALSFVLLFTAPDLSPTGKLI--YALVTYLLLGLAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 179 LLLSAAIPEQAfmQWGWRIPFIASAILVIVGLYI-RLKLHETPAFQKVLDKQKEVnipFKEVVTKHTGKLILgtIAAICT 257
Cdd:COG2211 168 PPLVAAFGGDA--ALGYRLTALIFAVLGLLAFLLtFFGTKERPVPEEEKVSLKES---LKALLKNRPFLLLL--LAYLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 258 FVVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKATSVgVCIAAAIFGLFFSSMLESGNT 337
Cdd:COG2211 241 FLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFI-IGLLLAALGLLLLFFLGPGNL 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490849955 338 LIVFLFLCtglsIMGLTYGPIGTVLSEIFPTSVRYTGSALTFNLAGIFGASFAplIATKLAETYGLYAVGYYLTAA 413
Cdd:COG2211 320 WLLLVLAA----LAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFT--FAIKLGQALAGALAGLLLALF 389
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
82-424 |
6.50e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.87 E-value: 6.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 82 GHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQigivapllLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRAWYGM 161
Cdd:cd17319 59 GWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 162 FPQLGAPIGFILATgsflLLSAAIPEQafmqWGWRIPFIASAILVIVGLYIRLKLHetpafqkvldkqkevnipfkevvt 241
Cdd:cd17319 131 LFNSGAPLGAAIGP----PLSGWLLLL----FGWRWAFIIEGLLGLLLAVLWWFYL------------------------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 242 KHTGKLILGTIAAICTFVVFylttvfaLNWGTTKLGYARG-EFLELQLFAT---LCFAAFIPLSAIFAEKFGRKATSVGV 317
Cdd:cd17319 179 RQVWGLALGYFGINYALYGL-------LTWLPTYLKQARGfSLKQVGLLAAipfLAGAIGMILGGRLSDRLLRGARRLVI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 318 CIAAAIFGLFFSSMLESGNTLIVFLFLCTGLSIMGLTYGPIGTVLSEIFPTSVRYTGSALtFNLAGIFGASFAPLIATKL 397
Cdd:cd17319 252 IIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGL-INSGGNLGGFVAPLLIGYL 330
|
330 340
....*....|....*....|....*...
gi 490849955 398 AETYGLYAVG-YYLTAASLLSLVAFLLI 424
Cdd:cd17319 331 VDATGSYTAAfLFLAAVALLAALLVLLL 358
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
72-402 |
9.02e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 44.29 E-value: 9.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 72 IARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQigivapllLAVCRLGQGLGLGGEWSGAVLLATENA 151
Cdd:TIGR00881 41 IAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWV--------MAALWALNGIFQGMGWPPCGRTVTKWF 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 152 PEGKRAWYGMFPQLGAPIGFILATGSFLLLSAaipeqafMQWGWRIPFIASAIL-VIVGLYIRLKLHETPAFQKV----- 225
Cdd:TIGR00881 113 SRSERGTWVSFWNCSHNVGGGLLPPLVLFGIA-------ELYSWHWVFIVPGIIaIIVSLICFLLLRDSPQSCGLppaee 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 226 --LDKQKEVNIPFKEVVTKHTGKL--ILGTIAA--ICTFVVF-YLTTVFALNWGTTKLGYARGEFLELQLFATLCF--AA 296
Cdd:TIGR00881 186 mpNEEPDGDAEKKEEELTKKQIFLqyVLLNKVLwyISLGYVFvYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYelGG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 297 FIP--LSAIFAEK-FGRKATSVGV-CIAAAIFGLFFSSMLESGNTLIVFLFlctGLSIMGLTYGP---IGTVLSEIFPTS 369
Cdd:TIGR00881 266 LVGtlLAGWLSDKlFNGRRGPLAVfFMALIIVSLLVYWLNPAANPLMDLIC---LFALGFLVYGPqmlIGVIASELAPKK 342
|
330 340 350
....*....|....*....|....*....|...
gi 490849955 370 VRYTGSALtFNLAGIFGASFAPLIATKLAETYG 402
Cdd:TIGR00881 343 AAGTAAGF-VGFFAYLGGILAGLPLGYLADGFG 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
67-425 |
1.48e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.69 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 67 FAIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAqigivaplLLAVCRLGQGLGLGGEWSGAVLL 146
Cdd:COG0738 49 LFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP--------LLLLALFLLGLGLGLLDVAANPY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 147 ATENAPEGKRA---WYGMFPQLGAPIGFILATgsfLLLSAAIPEQafmqwgWRIPFIASAILVIVgLYIRLKLHETPAFQ 223
Cdd:COG0738 121 VAALGPETAASrlnLLHAFFSLGALLGPLLGG---LLILLGLSLS------WHLPYLILAVLLLL-LALLFLRSKLPEIE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 224 KVLDKQKEVNIPFKEVvtKHTGKLILGTIAAICTFVVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAI 303
Cdd:COG0738 191 EEEEEAAGSAASLKSL--LKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGF 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 304 FAEKFGRKATSVGVCIAAAIFGLFFssMLESGNTLIVFLFLCTGLSiMGLTYGPIGTVLSEIFPTSVRYTGSALTFnlAG 383
Cdd:COG0738 269 LLKRFGPVRLLRLSALLAAVGLLLA--LLAPGPWLALIGLALVGLG-LSLMFPTIFSLALDGLGKRTAAAVSAVLI--MG 343
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 490849955 384 IFGASFAPLIATKLAETYGLYAVGYYLTAASLLSLVAFLLIR 425
Cdd:COG0738 344 IVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
76-406 |
1.89e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 43.32 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 76 IGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTyAQIGIVAPLLLAVcrlgqglglggewsgAVLLAT------- 148
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPN-FTIFIIARIIGGL---------------AVGGASalvpmyi 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 149 -ENAPEGKRAWYGMFPQLGAPIGFILATGSFLLLSAAIPEQAFMQWGWRIPFIASAILVIVGLYIRLKLHETPAFqkvld 227
Cdd:cd17359 115 aEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW----- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 228 kqkevnipfkeVVTKHTGKLILGTIAAI------CTFVVFYLTTVFalnwgtTKLGYARGEFLELQLFATLCFAAFIPLS 301
Cdd:cd17359 190 -----------LVSKGKPILIIGIGLAIfqqfvgINVIFYYGPEIF------QNAGFSENAALLQTIGIGVVNVIFTIIA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 302 AIFAEKFGRKAT----SVGVCIAAAIFGLFFSSMLESGNT-LIVFLFLCTGLSIMGLTYGPIGTV-LSEIFPTSVRYTGS 375
Cdd:cd17359 253 ILLVDKVGRKPLlligSIGMAISLLLIGTAFYFAPGSQASgIVALVLILLFVAFFAMSWGPVTWVlLSEIFPNRIRGLAM 332
|
330 340 350
....*....|....*....|....*....|....*.
gi 490849955 376 ALT--FNLAG--IFGASFAPLIAT-KLAETYGLYAV 406
Cdd:cd17359 333 GIAvfFLWIAnfLVSLTFPILLAAfGLAFTFLIFAV 368
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
77-397 |
9.68e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.10 E-value: 9.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 77 GAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQIgIVAPLLLAVCRlgqglglggewsGAVL-----LATENA 151
Cdd:PRK11551 66 GALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSL-LVARLLTGVGL------------GGALpnliaLTSEAV 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 152 PEGKRAWYGMFPQLGAPIGFILATGSFLLLSAAIpeqafmqwGWRIPFIASAI--LVIVGLYIRLkLHETPAFQKVlDKQ 229
Cdd:PRK11551 133 GPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDA--------AWRHIFYVGGVgpLLLVPLLMRW-LPESRAFAQA-AGA 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 230 KEVNIPFKEVVTK--HTGKLILGTIAAICTFVVFYlttvFALNWGTTKL---GYARGEFLELQLFATLCFAAFIPLSAIF 304
Cdd:PRK11551 203 GKQRAPVLRALFGegRATATLLLWISYFFTLIVLY----FLLNWLPSLLvgqGLSRSQAGLVQIAFNIGGALGSLLIGAL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 305 AEKFGRKATSVGV--CIAAAIFGLFFSSmleSGNTLIVFLFLCtGLSIMG---LTYGpigtvLSEIF-PTSVRYT--GSA 376
Cdd:PRK11551 279 MDRLRPRRVVLLIyaGILASLAALAAAP---SFAGMLLAGFAA-GLFVVGgqsVLYA-----LAPLFyPTQVRGTgvGAA 349
|
330 340
....*....|....*....|.
gi 490849955 377 LTfnlAGIFGASFAPLIATKL 397
Cdd:PRK11551 350 VA---VGRLGSMAGPLLAGQL 367
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
76-428 |
1.13e-03 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 40.85 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 76 IGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAqigivaplLLAVCRLGQGLGLGGEWSGAVLLATENAPEGK 155
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYP--------VLMVGRFVAGIGVGFALMIAPVYTAEVAPASS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 156 RAWYGMFPQLGAPIGFILATGSFLLLSaAIPeqafMQWGWRIPFIASAILVIVGLYIRLKLHETPAFQKVLDKQKEVNIP 235
Cdd:cd17437 119 RGFLTSFPEIFINIGILLGYVSNYAFS-GLP----LHVGWRLMLGVGAVPSLFLAIGVLAMPESPRWTPAVRRMLIAALG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 236 FkevvtkHTGKLILGTIAaictfVVFYLTTVFALNWGTTKLGyargeflelQLFATLCF----AAFIPLSAIFAEKFGRK 311
Cdd:cd17437 194 I------HFFQQASGIDA-----VVLYSPRIFKKAGIKSKDK---------LLLATVAVgvtkTLFILVATFLLDKVGRR 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 312 A---TSVG---VCIAAAIFGLFFSSMLESGNTLIVFL---FLCTGLSIMGLTYGPIGTVL-SEIFPTSVRYTGSALTFNL 381
Cdd:cd17437 254 PlllTSTGgmtLSLTALATSLTFIDRNGGGLTWALVLaitAVCSFVAFFSIGAGPITWVYsSEIFPLRLRAQGASLGVVV 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 490849955 382 ----AGIFGASFAPLI-ATKLAETYGLYAVgyyltAASLLSLVAFLLIRETK 428
Cdd:cd17437 334 nrlmSGTVSMTFLSMSkAITTGGTFFLFAG-----VAAAAWVFFYFFLPETK 380
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
252-435 |
1.16e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 252 IAAICTFVVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFGRKATSVGVCIAAAIFGLFFssM 331
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL--L 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 332 LESGNTLIVFLFLCTGLSiMGLTYGPIGTVLSEIFPTSVRYTGSALtFNLAGIFGASFAPLIATKLAETYGLYAVGYYLT 411
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLG-AGALFPAALALIADWFPPEERGRALGL-VSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180
....*....|....*....|....
gi 490849955 412 AASLLSLVAFLLIRETKNEDVNNQ 435
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKP 182
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
80-395 |
1.39e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.62 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 80 LFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQIgIVAPLLLAVcrlgqglglggewSGAVLLATENA------PE 153
Cdd:cd17321 50 LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAARALQGI-------------GAAAIMPASLAliaatfPG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 154 GKR----AWYGMFPQLGAPIGFILatGSFLLLSaaipeqafmqWGWRIPFIASAILVIVGLYIrlklheTPAFqkvldkq 229
Cdd:cd17321 116 ERRgralGLWGAVVGIGAALGPLL--GGLLLEL----------FGWRWIFLINVPIGLVALLL------ARTF------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 230 kevnipfkevvtkhTGKLILGTIAAICTFVVFYLTTVFALNWgttkLGYARGEFLELQLFATLCFAAFIPLSAIFAEKFG 309
Cdd:cd17321 171 --------------SGAVLAAFLLGAALGGLLFLLPLYLQGV----LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 310 -RKATSVGVCIAAAIFGLFFSSMLESGNTLIVFLFLCTGLSiMGLTYGPIGTVLSEIFPTSVRYTGSAL---TFNLAGIF 385
Cdd:cd17321 233 pRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLG-LGLFATPLTNAALSSVPKEKAGAASGIlntARQLGGAL 311
|
330
....*....|
gi 490849955 386 GASFAPLIAT 395
Cdd:cd17321 312 GVALLGALLT 321
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
76-428 |
1.54e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 40.70 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 76 IGAALFGHLGDRIGRKATLVaalltMGISTVCIGLLPTYAQIGIVAPLLlaVCRLGQGLGLGGEWSGAVLLATENAPEGK 155
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQ-----IGCVIYIIGAIIQVAAIGKWYQLI--VGRIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 156 R----AWYGMFPQLGAPIGFILATGSFLLLSAAipeqafmqwGWRIPF---IASAILVIVGLYirlKLHETPAFQKvldk 228
Cdd:cd17356 133 RgtlvSLYQLAITIGILVAYCINYGTHKLDGSA---------QWRIPLglqIVWGLLLLIGMF---FLPESPRWLY---- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 229 qkevnipfkevvtkhtgKLILGTIAAI------CTFVVFYLTTVFAlnwgttKLGYARGEFLELQLFATLCFAAFIPLSA 302
Cdd:cd17356 197 -----------------RTILGIMLQLfqqltgINYFFYYGTTIFQ------STGLTGSSPLLTSIILYIVNFVSTIPGL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 303 IFAEKFGRK----ATSVGVCIAAAIFGLFFSSML-----------ESGNTLIVFLFLCTGlsIMGLTYGPIGTVL-SEIF 366
Cdd:cd17356 254 FFVDKFGRRtcllIGAAGMSICLFIYAAVGVRYLipnpqsgtsnkSAGNGMIVFICLFIF--SFATTWGPIAWVYvAEVF 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490849955 367 PTSVRYTGSAL--TFNLAGIFGASFA-PLIATKLAETYGLYAVGYYLtaasLLSLVAFLLIRETK 428
Cdd:cd17356 332 PLRVRSKGMALatAFNWLWNFLISFFtPFIIGSIGFKYYYIFAGCNL----LAFIVVFFFVPETK 392
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
68-425 |
2.55e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.95 E-value: 2.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 68 AIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQIgivaplllAVCRLGQGLGLGGEW-SGAVLL 146
Cdd:cd17312 45 SAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFF--------AVLWGLNGLFQSMGWpPCVKLL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 147 ATENAPEGKRAWYGM---FPQLGAPIGFILATGSFLLLsaaipeqafmqwGWRIPFIASAILVIVG-LYIRLKLHETPAF 222
Cdd:cd17312 117 GNWFSKKERGTVYGIwstSHNFGGILAPILAASLASYY------------GWRAAFLVPGIVGLVVaIILFFFLRDSPPY 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 223 qkvldkqkevnipfkevvtkhtgkLILGTIAAICTFVVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSA 302
Cdd:cd17312 185 ------------------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 303 IFAEKF--GRKATSVGVCIAAAIFGLFFSSMLESGNTLIVFLFLCTGLSIMGLtYGPIGTVLSEIFPTSvRYTGSALTF- 379
Cdd:cd17312 241 LLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGP-INLIGGAAAQDIGRK-EAAGTATGFv 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 490849955 380 NLAGIFGASFAPLIATKLAETYGLYAVGYYLTAASLLSLVAFLLIR 425
Cdd:cd17312 319 GLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
288-423 |
3.24e-03 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 39.40 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 288 LFATLCFAAFIPLSAIFAEKFGRKATsvgVCIAAAIFGLFFS--SMLESGNTLIVFLFLCTGLSIMGLTYGPIGTvlSEI 365
Cdd:cd17442 243 IISTLGEIALNPLNILGINFLGRRLS---LVITMGLTAIFFLllNICTSSAGLTIFLFMLRALVSANFNTVYIYT--AEV 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 490849955 366 FPTSVRYTGSALTFNLAGIfGASFAPLIATKLAETYGLYAVGYYLTAASLLSLVAFLL 423
Cdd:cd17442 318 YPTTMRALGMGTSGSLCRI-GAMVAPFISQVLMSASVLGALCLFSSVCIVCAISAFTL 374
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
288-423 |
3.29e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 39.44 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 288 LFATLCFAAFIPLSAIFAEKFGRKATSVGVCIAAAIFGLFFSSMlESGNTLIVFLFLCTGLSIMGLTYGPIGTvlSEIFP 367
Cdd:cd17372 236 FIATFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLIC-QSPFILTVLLFGGRACISAAFTVVYIYT--PEVYP 312
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 490849955 368 TSVRYTGSALTFNLAGIfGASFAPLIATKLAETYGLYAVGYYLTAASLLSLVAFLL 423
Cdd:cd17372 313 TAVRALGVGTGSSVGRI-GAILCPFIAQVLVHGSQTIALLLFSVVCLVSAICVCLL 367
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
65-424 |
3.65e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.52 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 65 ATFAIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQIGIVAPLLLAVCRLGQGLGLGGEWSGAV 144
Cdd:cd06173 38 LVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 145 -LLATENAPEGKRAWYGMFPQLGAPIGFILATgsfLLLSAAIPEQAFMqwgwrIPFIASAILVIVGLYIRLKLHETPAFQ 223
Cdd:cd06173 118 pELVPKEQLVRANALNSLATQLARIIGPALGG---LLVALLGPGGAFA-----INALSFLLSALLLLFIRRPPPAAPGES 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 224 KVLDKQKEVNIPFkevVTKHTGKLILGTIAAICTFVVFYLTTVFALNWGTTKLGYARGEFlelqLFATLCFAAFIPLSAI 303
Cdd:cd06173 190 SSLLLRDLREGLR---YLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGY----GLLLAAFGVGALLGAL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 304 FAEKFGRKATSVGVC-IAAAIFGLFFSSM-LESGNTLIVFLFLCTGLSiMGLTYGPIGTVLSEIFPTSVRytGSALTFNL 381
Cdd:cd06173 263 LLGRLSKRRRRGRLLlIGALLLGLALLVLgLSPSLWLLLAALFLLGLA-GGLFNVPLNTLLQLRVPDELR--GRVFSVYN 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 490849955 382 AGIFGA-SFAPLIATKLAETYGLYAVGYYLTAASLLSLVAFLLI 424
Cdd:cd06173 340 ALNSGAmPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
76-428 |
5.57e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 38.87 E-value: 5.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 76 IGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAqigivaplLLAVCRLGQGLGLGGEWSGAVLLATENAPEGK 155
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 156 RAWYGMFPQLGAPIGFILATGSFLLLSAAIpeqafmqWGWRIPF-IASAILVIVGLYIrLKLHETPAFQKvldkqkevni 234
Cdd:cd17362 126 RGLLVSLKELFIVLGILLGYVSGYAFADVV-------GGWRYMYgLAAPPALLLGIGM-WFLPPSPRWQG---------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 235 PFKEVVTKHTGKLILGTIAAICTfVVFYLTTVFalnwgtTKLGYARGEFLELQLFATLCFAAFIPLSAIF-AEKFGRKAT 313
Cdd:cd17362 188 NYRKPLIIGLGLVLFQQITGQPS-VLYYAATIF------KSAGFSAASDATLVSVGLGVFKLLMTIVAVLlVDKLGRRPL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 314 SVGVC--IAAAIFGL-FFSSMLESGNTLIVFLFLCTGLSIMG---LTYGPIG-TVLSEIFPTSVRYTGSALT--FNLAGI 384
Cdd:cd17362 261 LLGGVsgMVVSLFLLaAYNLFVQMGPAGLAWLSLVALLLYVGayqISFGPISwLMVSEIFPLRVRGRAIALAvlVNFGSN 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 490849955 385 FGASFAPLIATKLAETYGLYAVGYYLTAASLLSLvaFLLIRETK 428
Cdd:cd17362 341 ALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFI--YFTVPETK 382
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
54-424 |
6.38e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.78 E-value: 6.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 54 SSGSAAVLQSLATFAIAFIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAQIgIVAPLLLAVCRLGQg 133
Cdd:cd17391 29 TSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQL-LILRLLQGVFSGYV- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 134 lglggewSGAVLLATENAPEGKRAWygmfpQLGApigfiLATGSFL------LLSAAIPEQAFMQwgwRIPFIASAILVI 207
Cdd:cd17391 107 -------PNATALIASQTPKEKSGW-----ALGT-----LSTGVVAgtligpLLGGFLADLFGIR---NVFFITGGLLFL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 208 VGLYIRLKLHEtpAFQKVldkQKEVNIPFKEVVTKHTGKLILgtiaaICTFVVFYLTTVFALNWGTTKLGYAR---GEFL 284
Cdd:cd17391 167 AFLLTLFFVKE--DFKPV---EKKKMVSTKEVWNSVPNPSLL-----ISLFVTTFIIQLANQSIEPILTLYIRqlmGDAS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 285 ELQLFATLCFAAFIPLSAIFAEKFGRKATSVG------VCIAAAIFGLFFSSMLESGNTLIVFLFLcTGLSIMGLTYGpI 358
Cdd:cd17391 237 NLAFISGLVFSATGVSSLLSAPRLGKLGDRIGhhrillGALLASALLYIPQAFVQTPWQLGILRFL-LGLATGGLLPA-I 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490849955 359 GTVLSEIFPTSVryTGSALTFNL-AGIFGASFAPLIATKLAETYGLYAVgYYLTAASLLSLVAFLLI 424
Cdd:cd17391 315 NSLLAKITPKEV--AGRIFGYNQsFQYLGNVAGPLLGSAIAAHFGYRAV-FVVTALLVLLNAIWSFI 378
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
53-423 |
7.35e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.34 E-value: 7.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 53 ASSGSAAVLQSLATFAiAFIARPIGaalfGHLGDRIGRKATLVAALLtmgistvcIGLLPTYAQIGIVAPLLLAVCRLGQ 132
Cdd:cd17489 28 GSEAVAGLVVGLFTLA-ALLARPFA----GRLLDRFGRKRLLLIGLL--------IFALATLLYLLATSVALLLVLRLIH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 133 GLGLGGEWSGAVLLATENAPEGKRA----WYGMFPQLGAPIGfiLATGSFLllsaaipeqaFMQWGWRIPFIASAILVIV 208
Cdd:cd17489 95 GIGWGAFTTAAATLVADIIPPSRRGegigYYGLATTLAMALG--PALGLFL----------YQHLGFAVLFIVAAVLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 209 GLYIRLKLHETPAFQKVLDKQKEVNIP--FKEVVTKHTGKLILGTIA--AICTFVVFYLTTVFALNWGTTKLGYArgefl 284
Cdd:cd17489 163 ALLLVFLVKDPPPVAAEEAEAGTRAFRrlVEKKVLPPALILFLASIAygAISTFLPLYAAERGISNAGLFFTVYA----- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 285 elqlfatLCFAAFIPLSAIFAEKFGRKaTSVGVCIAAAIFGLFFSSMLESGNTLIVFLFLcTGLSiMGLTYGPIGTVLSE 364
Cdd:cd17489 238 -------IALLLSRPFSGKLSDRKGPK-TVIIPGLLLLALGLLLLSFAGSPWMLLLAAVL-YGLG-FGLLFPALQALAVD 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490849955 365 IFPTSVRYTGSAlTFNLAGIFGASFAPLIATKLAETYGlYAVGYYLTAASLLSLVAFLL 423
Cdd:cd17489 308 LVPPHRRGAANG-TFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
71-425 |
8.38e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.33 E-value: 8.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 71 FIARPIGAALFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAqigivaplLLAVCRLGQGLglggewSGAVL----- 145
Cdd:cd17504 41 LLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLP--------VLIAGRALQGI------GGAVFplafa 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 146 LATENAPEGKraWYGMFPQLGAPIGFILATGsfLLLSAAIPEqafmQWGWRIPFIASAILVIVGLYIrlklheTPAFQKV 225
Cdd:cd17504 107 LVREEFPPER--VPVAQGILSATFGIGAGIG--LPLGGWIVQ----HLGWRWIFWTAAPVAVLLAAL------VPLIDLR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 226 LDKQKEVNIPfkevvtkhtgkLILGTIAAICTFVVFYLTTVFALNWGTTKLGYARGEFLELQLFATLCFAAFIPLSAIFA 305
Cdd:cd17504 173 LLRRRNVLLA-----------NITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490849955 306 EKFGRKATsvgVCIAAAIFGLFFSSMLESGNTLIVFLFLCTGLSI-MGLTYGPIGTVLSEIFP-----------TSVRYT 373
Cdd:cd17504 242 ARVGPRRV---LLIGLVISAVGLLLLALLHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPpdrtgiatgmnTVLRTI 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 490849955 374 GSALTFNLAGIFGASFAPLIATKLAETYGLYAVGYYL-TAASLLSLVAFLLIR 425
Cdd:cd17504 319 GSAIGPAIAGAILTTYTVSITSGGVPTEGAYVLAFLIgAALALAALLLSLLIP 371
|
|
| |
