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Conserved domains on  [gi|490870219|ref|WP_004732234|]
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MULTISPECIES: MIP/aquaporin family protein [Vibrio]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 10001739)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|8849412|11473620
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 8-257 1.93e-83

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


:

Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 250.04  E-value: 1.93e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   8 SLFGQCLAEFIGTGLLIFFGVGCVAALVLTGATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAK 87
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  88 VVPYIISQLLGAFCSAALVYSLYSNLFTDYEiahnfvrssqDALSTAGIFSTYPHASLSFFGAFAVEFVITAVLMFAILA 167
Cdd:COG0580   81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE----------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219 168 LGDENNgaSRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAYFagwdfaLSGARDIPYFIVPILAPIAGACF 247
Cdd:COG0580  151 ITDKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL------GKGGSDWGYLWVPIVAPILGAAL 222

                        250
                 ....*....|
gi 490870219 248 GGWLYPRVIG 257
Cdd:COG0580  223 AALLYRALFG 232
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 8-257 1.93e-83

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 250.04  E-value: 1.93e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   8 SLFGQCLAEFIGTGLLIFFGVGCVAALVLTGATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAK 87
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  88 VVPYIISQLLGAFCSAALVYSLYSNLFTDYEiahnfvrssqDALSTAGIFSTYPHASLSFFGAFAVEFVITAVLMFAILA 167
Cdd:COG0580   81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE----------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219 168 LGDENNgaSRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAYFagwdfaLSGARDIPYFIVPILAPIAGACF 247
Cdd:COG0580  151 ITDKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL------GKGGSDWGYLWVPIVAPILGAAL 222

                        250
                 ....*....|
gi 490870219 248 GGWLYPRVIG 257
Cdd:COG0580  223 AALLYRALFG 232
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-252 3.59e-72

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 221.36  E-value: 3.59e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  12 QCLAEFIGTGLLIFFGVGCVAALVLTGAT-FGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAKVVP 90
Cdd:cd00333    2 KYLAEFLGTFLLVFFGCGSVLAVKLAGGAsGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  91 YIISQLLGAFCSAALVYSLYSNLFTDYEIAHNFVrssqdalstAGIFSTYPHASLSFFGAFAVEFVITAVLMFAILALGD 170
Cdd:cd00333   82 YIIAQLLGAILGAALLYGLYYGLYLEFLGANNIV---------AGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219 171 ENNGASRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAYFagwdfalsgARDIPYFIVPILAPIAGACFGGW 250
Cdd:cd00333  153 DPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGL---------ARHWHYFWVYWVGPLIGAIAGAL 223


                 ..
gi 490870219 251 LY 252
Cdd:cd00333  224 VY 225
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 5-257 5.04e-58

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 187.26  E-value: 5.04e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   5 KHPSLFGQCLAEFIGTGLLIFFGVGCVAALVLTGATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFD 84
Cdd:PTZ00016  45 EYRPNVREYVAEFLGTFVLLFFGEGVVATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFP 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  85 KAKVVPYIISQLLGAFCSAALVYSLYSNLFTDYEIAHNFVRSSqdALSTAGIFSTYPHASLsfFGAFAVEFVITAVLMFA 164
Cdd:PTZ00016 125 WKKLPGYFVAQLLGAFVGAACVYGLYYGFFKDHGIPELPWETM--ANGFAGVFATYPREGN--FYAIFSELILTAILLLV 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219 165 ILALGDENNGASRGAMnPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAYFAGWDFALSgaRDIPYFIVPILAPIAG 244
Cdd:PTZ00016 201 ILAITDPNNCPAFNYL-PVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAILWGSEVFT--KDNYYFWVPLVAPFVG 277

                        250
                 ....*....|...
gi 490870219 245 ACFGGWLYPRVIG 257
Cdd:PTZ00016 278 AVLGMFLYDKFIP 290
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 5-252 1.50e-56

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 181.36  E-value: 1.50e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219    5 KHPSLFGQCLAEFIGTGLLIFFGVGC---VAALVLTGATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFH 81
Cdd:pfam00230   3 RSVSFLRAVIAEFLATLLFVFFGVGSalgVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   82 GFDKAKVVPYIISQLLGAFCSAALVYSLYSNlftdyeiahnfvrssqdaLSTAGIFSTYPHASLSFFGAFAVEFVITAVL 161
Cdd:pfam00230  83 RFSLLRAIFYIVAQLLGAIAGAALLYGVTVG------------------LQRAGLFANTLAPGVNAGQAFVVEIILTFQL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  162 MFAILALGDENNGASRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAYfagwdfalsgarDIPYFIVPILAP 241
Cdd:pfam00230 145 VYCVFATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLW------------KWDDHWVYWVGP 212

                         250
                  ....*....|.
gi 490870219  242 IAGACFGGWLY 252
Cdd:pfam00230 213 FIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 15-252 9.79e-55

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 176.34  E-value: 9.79e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   15 AEFIGTGLLIFFGVGCVAALVLTG-----ATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAKVV 89
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGaygavGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   90 PYIISQLLGAFCSAALVYSLYSNLFtdyeiAHNFVrssqdalstagiFSTYPHASLSFFGAFAVEFVITAVLMFAILALG 169
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLF-----PGNLA------------VNGSASAGVSSGQAFFVEFIGTAILVLVIFATT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  170 DENNGASRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAYFAGWdfalsgardiPYFIVPILAPIAGACFGG 249
Cdd:TIGR00861 144 DDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGW----------GNHWVYWVGPIIGAILGA 213


                  ...
gi 490870219  250 WLY 252
Cdd:TIGR00861 214 LVY 216
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 8-257 1.93e-83

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 250.04  E-value: 1.93e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   8 SLFGQCLAEFIGTGLLIFFGVGCVAALVLTGATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAK 87
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  88 VVPYIISQLLGAFCSAALVYSLYSNLFTDYEiahnfvrssqDALSTAGIFSTYPHASLSFFGAFAVEFVITAVLMFAILA 167
Cdd:COG0580   81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE----------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219 168 LGDENNgaSRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAYFagwdfaLSGARDIPYFIVPILAPIAGACF 247
Cdd:COG0580  151 ITDKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL------GKGGSDWGYLWVPIVAPILGAAL 222

                        250
                 ....*....|
gi 490870219 248 GGWLYPRVIG 257
Cdd:COG0580  223 AALLYRALFG 232
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-252 3.59e-72

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 221.36  E-value: 3.59e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  12 QCLAEFIGTGLLIFFGVGCVAALVLTGAT-FGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAKVVP 90
Cdd:cd00333    2 KYLAEFLGTFLLVFFGCGSVLAVKLAGGAsGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  91 YIISQLLGAFCSAALVYSLYSNLFTDYEIAHNFVrssqdalstAGIFSTYPHASLSFFGAFAVEFVITAVLMFAILALGD 170
Cdd:cd00333   82 YIIAQLLGAILGAALLYGLYYGLYLEFLGANNIV---------AGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219 171 ENNGASRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAYFagwdfalsgARDIPYFIVPILAPIAGACFGGW 250
Cdd:cd00333  153 DPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGL---------ARHWHYFWVYWVGPLIGAIAGAL 223


                 ..
gi 490870219 251 LY 252
Cdd:cd00333  224 VY 225
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 5-257 5.04e-58

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 187.26  E-value: 5.04e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   5 KHPSLFGQCLAEFIGTGLLIFFGVGCVAALVLTGATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFD 84
Cdd:PTZ00016  45 EYRPNVREYVAEFLGTFVLLFFGEGVVATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFP 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  85 KAKVVPYIISQLLGAFCSAALVYSLYSNLFTDYEIAHNFVRSSqdALSTAGIFSTYPHASLsfFGAFAVEFVITAVLMFA 164
Cdd:PTZ00016 125 WKKLPGYFVAQLLGAFVGAACVYGLYYGFFKDHGIPELPWETM--ANGFAGVFATYPREGN--FYAIFSELILTAILLLV 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219 165 ILALGDENNGASRGAMnPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAYFAGWDFALSgaRDIPYFIVPILAPIAG 244
Cdd:PTZ00016 201 ILAITDPNNCPAFNYL-PVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAILWGSEVFT--KDNYYFWVPLVAPFVG 277

                        250
                 ....*....|...
gi 490870219 245 ACFGGWLYPRVIG 257
Cdd:PTZ00016 278 AVLGMFLYDKFIP 290
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 5-252 1.50e-56

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 181.36  E-value: 1.50e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219    5 KHPSLFGQCLAEFIGTGLLIFFGVGC---VAALVLTGATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFH 81
Cdd:pfam00230   3 RSVSFLRAVIAEFLATLLFVFFGVGSalgVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   82 GFDKAKVVPYIISQLLGAFCSAALVYSLYSNlftdyeiahnfvrssqdaLSTAGIFSTYPHASLSFFGAFAVEFVITAVL 161
Cdd:pfam00230  83 RFSLLRAIFYIVAQLLGAIAGAALLYGVTVG------------------LQRAGLFANTLAPGVNAGQAFVVEIILTFQL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  162 MFAILALGDENNGASRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAYfagwdfalsgarDIPYFIVPILAP 241
Cdd:pfam00230 145 VYCVFATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLW------------KWDDHWVYWVGP 212

                         250
                  ....*....|.
gi 490870219  242 IAGACFGGWLY 252
Cdd:pfam00230 213 FIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 15-252 9.79e-55

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 176.34  E-value: 9.79e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   15 AEFIGTGLLIFFGVGCVAALVLTG-----ATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAKVV 89
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGaygavGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   90 PYIISQLLGAFCSAALVYSLYSNLFtdyeiAHNFVrssqdalstagiFSTYPHASLSFFGAFAVEFVITAVLMFAILALG 169
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLF-----PGNLA------------VNGSASAGVSSGQAFFVEFIGTAILVLVIFATT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  170 DENNGASRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAYFAGWdfalsgardiPYFIVPILAPIAGACFGG 249
Cdd:TIGR00861 144 DDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGW----------GNHWVYWVGPIIGAILGA 213


                  ...
gi 490870219  250 WLY 252
Cdd:TIGR00861 214 LVY 216
PLN00184 PLN00184
aquaporin NIP1; Provisional
 14-255 5.74e-25

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 100.87  E-value: 5.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  14 LAEFIGTGLLIFFGVGCVAALVLTGATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAKVVPYII 93
Cdd:PLN00184  58 IAEVLGTYFLVFTGCASVVVNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLKQVPAYVI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  94 SQLLGAFCSAALVYSLYSnlftdyeIAHNFVRSSQDALstagiFSTYPhaSLSFFGAFAVEFVITAVLMFAILALGDENN 173
Cdd:PLN00184 138 SQVIGSTLAAATLRLLFG-------LDHDVCSGKHDVF-----IGSSP--VGSDLQAFVMEFIVTFYLMFIISGVATDNR 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219 174 G----ASRGAMNPLLIGILIAviggslGPLTGFAMNPARDFGPKLF--AYFAGWDFalsgardipyfivpILAPIAGACF 247
Cdd:PLN00184 204 AigelAGLAIGSTVLLNVLIA------APVSSASMNPGRSLGPAMVygCYKGIWIY--------------IVAPTLGAIA 263


                 ....*...
gi 490870219 248 GGWLYPRV 255
Cdd:PLN00184 264 GAWVYNTV 271
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 14-252 8.62e-25

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 99.93  E-value: 8.62e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  14 LAEFIGTGLLIFFGVGCVAALVLTGATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAKVVPYII 93
Cdd:PLN00183  49 LAEMVGTFILMFCVCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLYIT 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  94 SQLLGAFCSAALVYSLYSnlftdyeiahnfvrssqdalSTAGIFSTYPhaSLSFFGAFAVEFVITAVLMFaiLALGDENN 173
Cdd:PLN00183 129 AQTVGSVLATYVGVSVYG--------------------VKADLMTTKP--AQGCSSAFWVEFIATFIVMF--LAASLTSQ 184

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490870219 174 GASRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAyfagWDFalsgaRDIPYFIVpilAPIAGACFGGWLY 252
Cdd:PLN00183 185 PQSLGHLSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVS----WDF-----KDIWIYIT---APTIGAVAGALMF 251
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 14-252 3.43e-21

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 90.35  E-value: 3.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  14 LAEFIGTGLLIFFGVGCVAALVLTGATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAKVVPYII 93
Cdd:PLN00182  46 IAEMIGTYFIIFSGCGVVVVNVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  94 SQLLGafcsaALVYSLYSNLFTDyeiahnfvrssqdaLSTAGIFSTYPHASLSffGAFAVEFVITAVLMFAILALGDENN 173
Cdd:PLN00182 126 AQLTG-----SLLASLTLRLMFN--------------VTPEAFFGTTPTDSSG--QALVAEIIISFLLMFVISGVATDSR 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219 174 GAsrGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLF--AYFAGWdfalsgardipyfiVPILAPIAGACFGGWL 251
Cdd:PLN00182 185 AV--GELAGIAVGMTIILNVFVAGPISGASMNPARSLGPAIVmgRYKGIW--------------VYIVGPFVGIIAGGFV 248


                 .
gi 490870219 252 Y 252
Cdd:PLN00182 249 Y 249
PRK05420 PRK05420
aquaporin Z; Provisional
 9-253 3.45e-18

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 81.17  E-value: 3.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   9 LFGQCLAEFIGTGLLIFFGVG-CVAALVLTGATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAK 87
Cdd:PRK05420   1 MFKKLAAEFFGTFWLVFGGCGsAVLAAAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  88 VVPYIISQLLGAFCSAALVYSLYSNLFTDYEIAHNFVRSSQDALSTAGifstyphasLSFFGAFAVEFVITAvlMFAILA 167
Cdd:PRK05420  81 LVPYIIAQVVGGIAAAAVLYLIASGKAGFDLAGSGFASNGYGEHSPGG---------YSLLAALVCEVVLTA--FFLLVI 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219 168 LGDENNGASRGaMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAyfAGWdfALSgarDIPYFIVpilAPIAGACF 247
Cdd:PRK05420 150 LGATDKRAPAG-FAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFV--GGW--ALE---QLWLFWV---APIVGAII 218


                 ....*.
gi 490870219 248 GGWLYP 253
Cdd:PRK05420 219 GGLIYR 224
PLN00026 PLN00026
aquaporin NIP; Provisional
 8-245 5.53e-18

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 81.83  E-value: 5.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   8 SLFGQCLAEFIGTGLLIFFGVGCVAALVLTGATFGQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAK 87
Cdd:PLN00026  69 SLTRKLGAEFVGTFILIFAATAGPIVNQKYDGAETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKH 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  88 VVPYIISQLLGAFCSAalvyslysnlFTDYEIAHNFVrssqdalsTAGIfsTYPhaSLSFFGAFAVEFVITAVLMFAILA 167
Cdd:PLN00026 149 VPAYIAAQVSASICAS----------FALKGVFHPFM--------SGGV--TVP--SVSTGQAFALEFIITFNLLFVVTA 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219 168 LGD------ENNGASRGAMnpLLIGILIAviggslGPLTGFAMNPARDFGPKLFA--YFAGWdfalsgardiPYFIVPIL 239
Cdd:PLN00026 207 VATdtravgELAGIAVGAT--VMLNILVA------GPSTGGSMNPVRTLGPAVAAgnYRAIW----------IYLVAPTL 268


                 ....*.
gi 490870219 240 APIAGA 245
Cdd:PLN00026 269 GALAGA 274
PLN00166 PLN00166
aquaporin TIP2; Provisional
 14-263 6.84e-13

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 66.88  E-value: 6.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  14 LAEFIGTGLLIFFGVGCVAAL--VLTGATF---GQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAKV 88
Cdd:PLN00166  22 LSEFIATLLFVFAGVGSAIAFakLTSDAALdpaGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITIITG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  89 VPYIISQLLGAFCSAALVyslysnlftdyeiahNFVrSSQDALSTAGIfstypHASLSFFGAFAVEFVITAVLMFAILAL 168
Cdd:PLN00166 102 FFYWIAQCLGSIVACLLL---------------VFV-TNGESVPTHGV-----AAGLGAIEGVVMEIVVTFALVYTVYAT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219 169 GDENNGASRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLfayfagwdfaLSGarDIPYFIVPILAPIAGACFG 248
Cdd:PLN00166 161 AADPKKGSLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAV----------VSG--DFSQIWIYWVGPLVGGALA 228

                        250
                 ....*....|....*.
gi 490870219 249 GWLYPRV-IGAYLPVE 263
Cdd:PLN00166 229 GLIYGDVfIGSYAAAP 244
PLN00167 PLN00167
aquaporin TIP5; Provisional
 14-216 2.91e-12

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 65.31  E-value: 2.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  14 LAEFIGTGLLIFFGVGCVAAL--VLTGATFGQWEISIIW---GFGVAIAIYCTAGVSGAHINPAVTIALAMFHGFDKAKV 88
Cdd:PLN00167  26 LAEFISTFFFVFAAVGSAMSSrkLMPDAASDPSSLLIVAianAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISVPTA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  89 VPYIISQLLGafcsaalvySLYSNLFTDYEIAHNFVRSSQDALSTAGifstyphaslsfFGAFAVEFVITAVLMFAILAL 168
Cdd:PLN00167 106 MFYWISQMLA---------SVMACLFLKVTTVGQHVPTYKIAEEMTG------------FGASVLEGVLTFGLVYTVYAA 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 490870219 169 GDENNGaSRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFA 216
Cdd:PLN00167 165 GDPRRG-LLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVA 211
PLN00027 PLN00027
aquaporin TIP; Provisional
 6-217 8.79e-09

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 54.79  E-value: 8.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219   6 HPSLFGQCLAEFIGTGLLIFFGVGCVAA---LVLTGATF--GQWEISIIWGFGVAIAIYCTAGVSGAHINPAVTIALAMF 80
Cdd:PLN00027  16 HPDALKAALAEFISTLIFVFAGEGSGMAfnkLTDNGSTTpaGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490870219  81 HGFDKAKVVPYIISQLLGAFCSAALVyslysnlftdyEIAHNFVRSSQDALStagifstyphASLSFFGAFAVEFVITAV 160
Cdd:PLN00027  96 GNITLLRGILYWIAQLLGSVVACLLL-----------KFSTGGLETSAFSLS----------SGVGVWNAFVFEIVMTFG 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 490870219 161 LMFAILALGDENNGASRGAMNPLLIGILIAVIGGSLGPLTGFAMNPARDFGPKLFAY 217
Cdd:PLN00027 155 LVYTVYATAVDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSW 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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