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Conserved domains on  [gi|490872740|ref|WP_004734744|]
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MULTISPECIES: antibiotic biosynthesis monooxygenase [Vibrio]

Protein Classification

antibiotic biosynthesis monooxygenase family protein( domain architecture ID 10006366)

antibiotic biosynthesis monooxygenase family protein may be involved in the biosynthesis of several antibiotics; similar to Streptomyces tetracenomycin-F1 monooxygenase and deoxynogalonate monooxygenase

CATH:  3.30.70.100
EC:  1.-.-.-
Gene Ontology:  GO:0004497|GO:0017000|GO:0016491
PubMed:  31399587
SCOP:  4001439

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 24-92 2.37e-13

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


:

Pssm-ID: 441901  Cd Length: 98  Bit Score: 60.78  E-value: 2.37e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490872740  24 PVVLINTFSVEPAHEAATLTYWEDARDVLVKQPGYISTKLHRSLSSDATYrfINVAEWESKKHFHDAIQ 92
Cdd:COG2329    1 MIVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEY--LVVSYWESEEAFRAWFR 67
 
Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 24-92 2.37e-13

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 60.78  E-value: 2.37e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490872740  24 PVVLINTFSVEPAHEAATLTYWEDARDVLVKQPGYISTKLHRSLSSDATYrfINVAEWESKKHFHDAIQ 92
Cdd:COG2329    1 MIVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEY--LVVSYWESEEAFRAWFR 67
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 25-95 7.33e-08

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 46.11  E-value: 7.33e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490872740   25 VVLINTFSVEPAHEAATLTYWEDARDVLVKQPGYISTKLHRSLSSDATYRFInvAEWESKKHF-----HDAIQAMR 95
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVL--EVWEDEAAFeahlqSPHFKAAH 74
 
Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 24-92 2.37e-13

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 60.78  E-value: 2.37e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490872740  24 PVVLINTFSVEPAHEAATLTYWEDARDVLVKQPGYISTKLHRSLSSDATYrfINVAEWESKKHFHDAIQ 92
Cdd:COG2329    1 MIVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEY--LVVSYWESEEAFRAWFR 67
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 25-95 7.33e-08

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 46.11  E-value: 7.33e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490872740   25 VVLINTFSVEPAHEAATLTYWEDARDVLVKQPGYISTKLHRSLSSDATYRFInvAEWESKKHF-----HDAIQAMR 95
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVL--EVWEDEAAFeahlqSPHFKAAH 74
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
25-101 2.76e-04

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 37.24  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490872740  25 VVLINTFSVEPAHEAATLTYWEDARDVLVKQPGYISTKLHRSLSSDATYRFInvAEWESKKHF-----HDAIQAMRKELP 99
Cdd:COG1359    1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLY--ERWEDEAALeahlaSPHFKAFLAALA 78


                 ..
gi 490872740 100 PL 101
Cdd:COG1359   79 PL 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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