|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01318 |
PRK01318 |
membrane protein insertase; Provisional |
1-540 |
0e+00 |
|
membrane protein insertase; Provisional
Pssm-ID: 234942 [Multi-domain] Cd Length: 521 Bit Score: 681.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 1 MDSQRNILLIALALVSFLLFQQWNVAQNPAPQaieqaqsgstlpapsyaddldpapgQQVASAKTITVTTDVLTLSIDTV 80
Cdd:PRK01318 1 MDNKRLLLAIALSFVIFLGWQYWQQDKAQAAA-------------------------QAPAPQARITVETDVLRLSIDTK 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 81 GGDVVQANLNDYSAEFDSEDTFVLLKNEPGHQFIAQSGLVGPQGIDLSST-NRPSYTVSADSFTLADGQDELRIPMTYQA 159
Cdd:PRK01318 56 GGRIDDLLLKKYKETLDSSPPVVLLSPSTEHPYFAQSGLTGADGPDNVPNpDRTLYTADGDSLVLADGQNELPVTLTWTN 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 160 -NGLDYTKTFVLKRGSYAMDVEYDVVNNSGTNATFGMYAHLRQnvmDDGGSLTMPTYRGGAYSTEDTRYKKYSFDDMQDR 238
Cdd:PRK01318 136 gNGLTFTKTYTLDRGDYMFTVEYSVNNNSGAPVNLSPYGQLKR---TGSSNFASYTFHGGAIGTPDEKYEKYTYKDIDDN 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 239 NlslNLANGQGWAAMIQHYFASAWIPRDEAGSNLYTRVIGNLGDIGVRMPNKTIATGDEASFKATLWVGPKLQDQMA-AV 317
Cdd:PRK01318 213 L---NISSKGGWVAILDKYFATALIPQNGQNNFYSKNLGNGLYQVGFKSPPVTVAPGQSASTTARLYAGPKEVKLLAkEI 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 318 APNLDLVVDYGWLWFIAKPLHTLLSFIQGIVVNWGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDD 397
Cdd:PRK01318 290 APGLDLAVDYGWLWFITKPLFWLLDFLHSFVGNWGWAIILLTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDD 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 398 RQRMSQEMMELYKKEKVNPLGGCLPIILQMPIFISLYWALMESVELRHSPFFGWITDLSAQDPYYIL-----PLLMGASM 472
Cdd:PRK01318 370 PQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVLLVSIELRHAPFIGWIHDLSAPDPYFILhigllPILMGITM 449
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490873802 473 FLIQKMSPTTvTDPMQQKIMTFMPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRALEKKGLHSK 540
Cdd:PRK01318 450 FLQQKLNPTP-TDPMQAKIMKFMPLIFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLEKKKLLAA 516
|
|
| yidC_nterm |
TIGR03593 |
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have ... |
3-348 |
3.05e-124 |
|
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274666 Cd Length: 366 Bit Score: 368.58 E-value: 3.05e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 3 SQRNILLIALALVSFLLFQQWNV-----AQNPAPQAIEQAQSGSTLPAPSYADDL------DPAPGQQVA-SAKTITVTT 70
Cdd:TIGR03593 1 NRRLILAIALSFVIFLLWQAWQSdpgppPPKPPAAAQEASAASATAAATSAAAPAaadapsAAAAADAAAaTAKRITVET 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 71 DVLTLSIDTVGGDVVQANLNDYSAEFDS-EDTFVLLKNEPGHQFIAQSGLVGPQGIDLSSTN-RPSYTVSADSFTLADGQ 148
Cdd:TIGR03593 81 DVLRASISTKGGDIDSLELKKYKETLDKdSPPVLLLSDGAERLYVAQSGLIGANGADLALPGhRTVWQAEGGEYTLTPGQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 149 deLRIPMTYQA-NGLDYTKTFVLKRGSYAMDVEYDVVNNSGTNATFGMYAHLRQNVMDD--GGSLTMPTYRGGAYSTEDT 225
Cdd:TIGR03593 161 --LPVTLTWDNsNGVTVTKTYTFDRDSYLIDVEYKVTNNGDAPVSLSLYGQLKRDLSPTekSTYFLHETFTGAAYYTDGE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 226 RYKKYSFDDMQDRNLSLNLANGQGWAAMIQHYFASAWIPRDEAGSN----LYTRVIGNLGDIGVRMPNKTIATGDEASFK 301
Cdd:TIGR03593 239 KYQKVSFKDIEKKKLNVETKGGAGWVGMLQHYFASAWIPPAGSDGTtafyYGRKLGNNVYIAGFVSPVVTVAPGQSATIK 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 490873802 302 ATLWVGPKLQDQMAAVAPNLDLVVDYGWLWFIAKPLHTLLSFIQGIV 348
Cdd:TIGR03593 319 SRLYAGPKEQDVLKAIAPGLDLAVDYGWLWFIAKPLFWLLDFFHSLV 365
|
|
| YidC |
COG0706 |
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis]; |
325-536 |
5.02e-113 |
|
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440470 [Multi-domain] Cd Length: 212 Bit Score: 334.01 E-value: 5.02e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 325 VDYGWLWFIAKPLHTLLSFIQGIVVNWGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDDRQRMSQE 404
Cdd:COG0706 1 IDYGWFGFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 405 MMELYKKEKVNPLGGCLPIILQMPIFISLYWALMESVELRHSPFFgWITDLSAQDPYYI-LPLLMGASMFLIQKMSPTTV 483
Cdd:COG0706 81 MMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPFL-GIPDLSAPDPYYIfLPILMGVTMFLQQKLNPAPA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 490873802 484 TDPMQQKIMTFMPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRALEKKG 536
Cdd:COG0706 160 QDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKKK 212
|
|
| YidC_periplas |
pfam14849 |
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein ... |
66-327 |
5.34e-102 |
|
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein which is required for the insertion and assembly of inner membrane proteins.
Pssm-ID: 464346 Cd Length: 266 Bit Score: 308.05 E-value: 5.34e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 66 ITVTTDVLTLSIDTVGGDVVQANLNDYSAEFDSEDT-FVLLKNEPGHQFIAQSGLVGPQGIDLSsTNRPSYTVSADSFTL 144
Cdd:pfam14849 1 ITVETDVLRGSISLKGGRIDDLELKKYRETLDDDSPpVVLLSPSGGRTYVAQSGLIGAGGPDLP-PHDTVFTAEGGSYTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 145 ADGQDELRIPMTYQA-NGLDYTKTFVLKRGSYAMDVEYDVVNNSGTNATFGMYAHLRQNVMDDGGSLTMPTYRGGAYSTE 223
Cdd:pfam14849 80 ADGTDELPVTLTWDNgNGVTFTKTYTFDRGSYLIDVTYEVENTSGAPVTLQPYGQLVRDPGEPEGSSFYITYTGAAGSTD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 224 DTRYKKYSFDDMQD-RNLSLNLANGQGWAAMIQHYFASAWIPRDEAGSN-LYTRVI-GNLGDIGVRMPNKTIATGDEASF 300
Cdd:pfam14849 160 EGKYQKVSFDDIEKgGKLKVDTTTGGGWVAMTQHYFLSAWIPDQDGTTNeFYTRFLgGNLYQAGYISPAVTVAPGASATV 239
|
250 260
....*....|....*....|....*..
gi 490873802 301 KATLWVGPKLQDQMAAVAPNLDLVVDY 327
Cdd:pfam14849 240 TARLFAGPKEQKVLEAIAPGLDLAVDY 266
|
|
| 5TM_YidC_Alb3 |
cd20070 |
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ... |
352-530 |
1.73e-92 |
|
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410994 [Multi-domain] Cd Length: 181 Bit Score: 280.42 E-value: 1.73e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 352 GLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDDRQRMSQEMMELYKKEKVNPLGGCLPIILQMPIFI 431
Cdd:cd20070 1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 432 SLYWALMESVELRHSPFFGWITDLSAQDPYYILPLLMGASMFLIQKMSPTTVT--DPMQQKIMTFMPVMFTFFFLFFPSG 509
Cdd:cd20070 81 ALYQVLRNSIELRGAPFLWWILDLSAPDPYYILPILMGVTMFLQQKLTPTPTDdqAPQQKMMMYFMPVMFTFIFLSFPSG 160
|
170 180
....*....|....*....|.
gi 490873802 510 LVLYWLVSNIVTLIQQTLIYR 530
Cdd:cd20070 161 LVLYWLVSNLFSIIQQLIINK 181
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01318 |
PRK01318 |
membrane protein insertase; Provisional |
1-540 |
0e+00 |
|
membrane protein insertase; Provisional
Pssm-ID: 234942 [Multi-domain] Cd Length: 521 Bit Score: 681.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 1 MDSQRNILLIALALVSFLLFQQWNVAQNPAPQaieqaqsgstlpapsyaddldpapgQQVASAKTITVTTDVLTLSIDTV 80
Cdd:PRK01318 1 MDNKRLLLAIALSFVIFLGWQYWQQDKAQAAA-------------------------QAPAPQARITVETDVLRLSIDTK 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 81 GGDVVQANLNDYSAEFDSEDTFVLLKNEPGHQFIAQSGLVGPQGIDLSST-NRPSYTVSADSFTLADGQDELRIPMTYQA 159
Cdd:PRK01318 56 GGRIDDLLLKKYKETLDSSPPVVLLSPSTEHPYFAQSGLTGADGPDNVPNpDRTLYTADGDSLVLADGQNELPVTLTWTN 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 160 -NGLDYTKTFVLKRGSYAMDVEYDVVNNSGTNATFGMYAHLRQnvmDDGGSLTMPTYRGGAYSTEDTRYKKYSFDDMQDR 238
Cdd:PRK01318 136 gNGLTFTKTYTLDRGDYMFTVEYSVNNNSGAPVNLSPYGQLKR---TGSSNFASYTFHGGAIGTPDEKYEKYTYKDIDDN 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 239 NlslNLANGQGWAAMIQHYFASAWIPRDEAGSNLYTRVIGNLGDIGVRMPNKTIATGDEASFKATLWVGPKLQDQMA-AV 317
Cdd:PRK01318 213 L---NISSKGGWVAILDKYFATALIPQNGQNNFYSKNLGNGLYQVGFKSPPVTVAPGQSASTTARLYAGPKEVKLLAkEI 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 318 APNLDLVVDYGWLWFIAKPLHTLLSFIQGIVVNWGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDD 397
Cdd:PRK01318 290 APGLDLAVDYGWLWFITKPLFWLLDFLHSFVGNWGWAIILLTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDD 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 398 RQRMSQEMMELYKKEKVNPLGGCLPIILQMPIFISLYWALMESVELRHSPFFGWITDLSAQDPYYIL-----PLLMGASM 472
Cdd:PRK01318 370 PQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVLLVSIELRHAPFIGWIHDLSAPDPYFILhigllPILMGITM 449
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490873802 473 FLIQKMSPTTvTDPMQQKIMTFMPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRALEKKGLHSK 540
Cdd:PRK01318 450 FLQQKLNPTP-TDPMQAKIMKFMPLIFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLEKKKLLAA 516
|
|
| yidC_nterm |
TIGR03593 |
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have ... |
3-348 |
3.05e-124 |
|
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274666 Cd Length: 366 Bit Score: 368.58 E-value: 3.05e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 3 SQRNILLIALALVSFLLFQQWNV-----AQNPAPQAIEQAQSGSTLPAPSYADDL------DPAPGQQVA-SAKTITVTT 70
Cdd:TIGR03593 1 NRRLILAIALSFVIFLLWQAWQSdpgppPPKPPAAAQEASAASATAAATSAAAPAaadapsAAAAADAAAaTAKRITVET 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 71 DVLTLSIDTVGGDVVQANLNDYSAEFDS-EDTFVLLKNEPGHQFIAQSGLVGPQGIDLSSTN-RPSYTVSADSFTLADGQ 148
Cdd:TIGR03593 81 DVLRASISTKGGDIDSLELKKYKETLDKdSPPVLLLSDGAERLYVAQSGLIGANGADLALPGhRTVWQAEGGEYTLTPGQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 149 deLRIPMTYQA-NGLDYTKTFVLKRGSYAMDVEYDVVNNSGTNATFGMYAHLRQNVMDD--GGSLTMPTYRGGAYSTEDT 225
Cdd:TIGR03593 161 --LPVTLTWDNsNGVTVTKTYTFDRDSYLIDVEYKVTNNGDAPVSLSLYGQLKRDLSPTekSTYFLHETFTGAAYYTDGE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 226 RYKKYSFDDMQDRNLSLNLANGQGWAAMIQHYFASAWIPRDEAGSN----LYTRVIGNLGDIGVRMPNKTIATGDEASFK 301
Cdd:TIGR03593 239 KYQKVSFKDIEKKKLNVETKGGAGWVGMLQHYFASAWIPPAGSDGTtafyYGRKLGNNVYIAGFVSPVVTVAPGQSATIK 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 490873802 302 ATLWVGPKLQDQMAAVAPNLDLVVDYGWLWFIAKPLHTLLSFIQGIV 348
Cdd:TIGR03593 319 SRLYAGPKEQDVLKAIAPGLDLAVDYGWLWFIAKPLFWLLDFFHSLV 365
|
|
| YidC |
COG0706 |
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis]; |
325-536 |
5.02e-113 |
|
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440470 [Multi-domain] Cd Length: 212 Bit Score: 334.01 E-value: 5.02e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 325 VDYGWLWFIAKPLHTLLSFIQGIVVNWGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDDRQRMSQE 404
Cdd:COG0706 1 IDYGWFGFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 405 MMELYKKEKVNPLGGCLPIILQMPIFISLYWALMESVELRHSPFFgWITDLSAQDPYYI-LPLLMGASMFLIQKMSPTTV 483
Cdd:COG0706 81 MMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPFL-GIPDLSAPDPYYIfLPILMGVTMFLQQKLNPAPA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 490873802 484 TDPMQQKIMTFMPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRALEKKG 536
Cdd:COG0706 160 QDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKKK 212
|
|
| YidC_periplas |
pfam14849 |
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein ... |
66-327 |
5.34e-102 |
|
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein which is required for the insertion and assembly of inner membrane proteins.
Pssm-ID: 464346 Cd Length: 266 Bit Score: 308.05 E-value: 5.34e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 66 ITVTTDVLTLSIDTVGGDVVQANLNDYSAEFDSEDT-FVLLKNEPGHQFIAQSGLVGPQGIDLSsTNRPSYTVSADSFTL 144
Cdd:pfam14849 1 ITVETDVLRGSISLKGGRIDDLELKKYRETLDDDSPpVVLLSPSGGRTYVAQSGLIGAGGPDLP-PHDTVFTAEGGSYTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 145 ADGQDELRIPMTYQA-NGLDYTKTFVLKRGSYAMDVEYDVVNNSGTNATFGMYAHLRQNVMDDGGSLTMPTYRGGAYSTE 223
Cdd:pfam14849 80 ADGTDELPVTLTWDNgNGVTFTKTYTFDRGSYLIDVTYEVENTSGAPVTLQPYGQLVRDPGEPEGSSFYITYTGAAGSTD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 224 DTRYKKYSFDDMQD-RNLSLNLANGQGWAAMIQHYFASAWIPRDEAGSN-LYTRVI-GNLGDIGVRMPNKTIATGDEASF 300
Cdd:pfam14849 160 EGKYQKVSFDDIEKgGKLKVDTTTGGGWVAMTQHYFLSAWIPDQDGTTNeFYTRFLgGNLYQAGYISPAVTVAPGASATV 239
|
250 260
....*....|....*....|....*..
gi 490873802 301 KATLWVGPKLQDQMAAVAPNLDLVVDY 327
Cdd:pfam14849 240 TARLFAGPKEQKVLEAIAPGLDLAVDY 266
|
|
| yidC_oxa1_cterm |
TIGR03592 |
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ... |
350-528 |
4.17e-96 |
|
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274665 [Multi-domain] Cd Length: 179 Bit Score: 289.38 E-value: 4.17e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 350 NWGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDDRQRMSQEMMELYKKEKVNPLGGCLPIILQMPI 429
Cdd:TIGR03592 1 NWGLAIILLTIIVRLILLPLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 430 FISLYWALMESVELRHSPFFgWITDLSAQDPYYILPLLMGASMFLIQKMSPTTVTDPMQQKIMT-FMPVMFTFFFLFFPS 508
Cdd:TIGR03592 81 FIALYQVLLRSIELRHAPFL-WIIDLSSPDPYYILPILMGVTMFLQQKLSPKGPPDPAQQKMMMyFMPLMFLFFFLSFPA 159
|
170 180
....*....|....*....|
gi 490873802 509 GLVLYWLVSNIVTLIQQTLI 528
Cdd:TIGR03592 160 GLVLYWVVSNLFTIIQQLII 179
|
|
| 60KD_IMP |
pfam02096 |
60Kd inner membrane protein; |
351-530 |
1.90e-94 |
|
60Kd inner membrane protein;
Pssm-ID: 460443 [Multi-domain] Cd Length: 187 Bit Score: 285.52 E-value: 1.90e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 351 WGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDDRQRMSQEMMELYKKEKVNPLGGCLPIILQMPIF 430
Cdd:pfam02096 1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 431 ISLYWALMESVELRHSPFFGWITDLSAQDP-----YYILPLLMGASMFLIQKMSPTTVTDPMQQKIMT--FMPVMFTFFF 503
Cdd:pfam02096 81 IALYRVLRNSIELRHAPFFLWIADLSAPDPisilhYYILPILMGVTMFLQQKLTPAPQDQPPQMKMMMlyFMPLMFLFFF 160
|
170 180
....*....|....*....|....*..
gi 490873802 504 LFFPSGLVLYWLVSNIVTLIQQTLIYR 530
Cdd:pfam02096 161 LNFPAGLVLYWVVSNLLSIGQQLIINR 187
|
|
| 5TM_YidC_Alb3 |
cd20070 |
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ... |
352-530 |
1.73e-92 |
|
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410994 [Multi-domain] Cd Length: 181 Bit Score: 280.42 E-value: 1.73e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 352 GLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDDRQRMSQEMMELYKKEKVNPLGGCLPIILQMPIFI 431
Cdd:cd20070 1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 432 SLYWALMESVELRHSPFFGWITDLSAQDPYYILPLLMGASMFLIQKMSPTTVT--DPMQQKIMTFMPVMFTFFFLFFPSG 509
Cdd:cd20070 81 ALYQVLRNSIELRGAPFLWWILDLSAPDPYYILPILMGVTMFLQQKLTPTPTDdqAPQQKMMMYFMPVMFTFIFLSFPSG 160
|
170 180
....*....|....*....|.
gi 490873802 510 LVLYWLVSNIVTLIQQTLIYR 530
Cdd:cd20070 161 LVLYWLVSNLFSIIQQLIINK 181
|
|
| 5TM_YidC_Oxa1_Alb3 |
cd19751 |
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ... |
352-530 |
3.65e-71 |
|
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410992 [Multi-domain] Cd Length: 189 Bit Score: 225.51 E-value: 3.65e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 352 GLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDD------RQRMSQEMMELYKKEKVNPLGGCLPIIL 425
Cdd:cd19751 1 GLSIIIVTILIRLALLPLTLKQQKSMRKMQVIRPEMEAIREKYKEKaskdkvQQEMQKEMLGLYKKHGVNPMAGCLPLFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 426 QMPIFISLYWALMESVELRHSPFFgWITDLSAQDPYYILPLLMGASMFLIQKMSPTTVT-----DPMQQKIMTFMPVMFT 500
Cdd:cd19751 81 QLPIFMAFYFAIMRTEEIRYHTFL-WFFDLGQPDYLYILPFVAGITTYFQFKMTMSHQQqmqmmQMQMKVMLYVMPVMII 159
|
170 180 190
....*....|....*....|....*....|
gi 490873802 501 FFFLFFPSGLVLYWLVSNIVTLIQQTLIYR 530
Cdd:cd19751 160 IAGLSFPSALSLYWIISNLFMIIQTYFIVR 189
|
|
| EcYidC-like_peri |
cd19961 |
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from ... |
64-327 |
2.10e-68 |
|
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Escherichia coli and similar domains; This subfamily is composed of Escherichia coli YidC and similar proteins. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contain a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich.
Pssm-ID: 411000 Cd Length: 255 Bit Score: 221.03 E-value: 2.10e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 64 KTITVTTDVLTLSIDTVGGDVVQANLNDYSAEFDSEDTFVLLKNEPGhqFIAQSGLVGPQGIDlSSTNRPSYTVSADSFt 143
Cdd:cd19961 1 KRITVETDLLKASISTKGGRIKSVELKKYKETLPDSKPVELLSPDGP--YVAQLGLIGADGPL-IPTADLLFTADSGSY- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 144 laDGQDELRIPMTYQ-ANGLDYTKTFVLKRGSYAMDVEYDVVNNSGTNATFGMYAHLRQNVMDDGGSLTMPTYRGGAYST 222
Cdd:cd19961 77 --EGGDSLTVTLTWTnGDGLTIEKTYTFDPDSYLIDVEVRVENNSSAPLSLSLYLQLQRKGGEPEGSGSTITYEGPAGTE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 223 EDtRYKKYSFDDMQDRNLSLnlANGqGWAAMIQHYFASAWIPRDEAGSNLYTRVIGNLGDIGVRMPNKTIATGDEASFKA 302
Cdd:cd19961 155 DG-KLEKLSFKDLEEEKLSS--GKV-GWVAFKQKYFLSALIPDQGFFYSAKLSGKDDGDGVKLLSAALTLPPGGSGTFSF 230
|
250 260
....*....|....*....|....*
gi 490873802 303 TLWVGPKLQDQMAAVAPNLDLVVDY 327
Cdd:cd19961 231 RLYAGPKDYDILKAYGPGLELAVDF 255
|
|
| PRK01315 |
PRK01315 |
putative inner membrane protein translocase component YidC; Provisional |
331-530 |
1.95e-45 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234941 Cd Length: 329 Bit Score: 162.60 E-value: 1.95e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 331 WFIAKPL---HTLLSFI----QGIVvnWGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDDRQRMSQ 403
Cdd:PRK01315 17 WVISGILvlfHTLLGFLfgpdSGLT--WVLSIVGLVIVIRALLIPLFVKQIKSQRNMQEIQPKMKKIQEKYKGDRERMSQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 404 EMMELYKKEKVNPLGGCLPIILQMPIFISLYWALMESVE---------------LRHSPFFG---WITDLSAQDPYY--- 462
Cdd:PRK01315 95 EMMKLYKETGTNPLSSCLPLLLQMPIFFALYRVLDSAASrgdgigpinppllesFRHAHIFGaplAATFLQALNAGNtav 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 463 -----ILPLLMGASMFLIQK------MSPTTVTDPM--QQKIMTFM-PVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLI 528
Cdd:PRK01315 175 qvvaaVLIILMSASQFITQLqlmtknMPPEAKTGPMaqQQKMLLYLfPLMFLVSGIAFPVGVLFYWLTSNVWTMGQQFYV 254
|
..
gi 490873802 529 YR 530
Cdd:PRK01315 255 IR 256
|
|
| 5TM_Oxa1-like |
cd20069 |
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ... |
351-527 |
7.27e-43 |
|
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410993 [Multi-domain] Cd Length: 201 Bit Score: 151.52 E-value: 7.27e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 351 WGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERI------GDD--RQRMSQEMMELYKKEKVNPLGGCLP 422
Cdd:cd20069 4 WWATIAATTVALRLLLLPLVIKSQRNAARMANLQPELQKLQEKLkearasGDQleAAEARKELKELMKKHNVNPLKSLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 423 IILQMPIFISLYWALMESVELRHSPF----FGWITDLSAQDPYYILPLLMGASMFLIQKMSPTTVTDPMQQ-----KIMT 493
Cdd:cd20069 84 PLVQAPVFISFFFALRKMANLPVPSFktggLLWFTDLTVPDPYYILPILTSLTFLATIELGAETGTSGSPQsktmkNVFR 163
|
170 180 190
....*....|....*....|....*....|....
gi 490873802 494 FMPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTL 527
Cdd:cd20069 164 GLPVLMIPFTANFPSAVFLYWITSNLFSLAQNLL 197
|
|
| PRK00145 |
PRK00145 |
putative inner membrane protein translocase component YidC; Provisional |
343-536 |
2.17e-42 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234665 [Multi-domain] Cd Length: 223 Bit Score: 151.05 E-value: 2.17e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 343 FIQGIVVN----WGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDDRQRMSQEMMELYKKEKVNPLG 418
Cdd:PRK00145 19 FVSSVISNpnfsYGIAIILVTLIIRLLILPLNIKQTKSSLRMNEIQPEIKKLQAKYKNDPQKLQQEMMKLYKEKGVNPLG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 419 GCLPIILQMPIFISLYWALMESVELRHSPFFgWITDLSAQDPYYILPLLMGASMFLIQK-MSPTTVTDPMQQKIMT-FMP 496
Cdd:PRK00145 99 GCLPLLIQWPILIALYYVFNNLTGINGVSFL-WIKDLAKPDITWILPILSGATTYLSGYlMTKADSSQAGQMKTMNiGMS 177
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 490873802 497 VMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRALEKKG 536
Cdd:PRK00145 178 IFMGVMSWKFKSALVLYWVIGNLIQIIQTYFIKKLELKKK 217
|
|
| PRK01001 |
PRK01001 |
putative inner membrane protein translocase component YidC; Provisional |
321-540 |
2.67e-41 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234887 [Multi-domain] Cd Length: 795 Bit Score: 158.81 E-value: 2.67e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 321 LDLVVDYGWLWFIAKP----LHTLLSFIQGIVVNWGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGD 396
Cdd:PRK01001 542 LDSITFRGFFSFITEPfaalLFIIMKFFKFLTGSWGISIILLTVFLKLLLYPLNAWSIRSMRRMQKLSPYIQEIQQKYKK 621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 397 DRQRMSQEMMELYKKEKVNPLGGCLPIILQMPIFISLYWALMESVELRHSPFF-GWITDLSAQD--------------PY 461
Cdd:PRK01001 622 EPKRAQMEIMALYKTNKVNPITGCLPLLIQLPFLIAMFDLLKSSFLLRGASFIpGWIDNLTAPDvlfswetpiwfignEF 701
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 462 YILPLLMGASMFLIQKMSPTTVTDPM-----QQKIM-TFMPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRALEKK 535
Cdd:PRK01001 702 HLLPILLGVVMFAQQKISSLKRKGPVtdqqrQQEAMgTMMALLFTFMFYNFPSGLNIYWLSSMLLGVIQQWVTNKILDSK 781
|
....*
gi 490873802 536 GLHSK 540
Cdd:PRK01001 782 HLKNE 786
|
|
| PRK02944 |
PRK02944 |
YidC family membrane integrase SpoIIIJ; |
329-528 |
9.89e-40 |
|
YidC family membrane integrase SpoIIIJ;
Pssm-ID: 179508 Cd Length: 255 Bit Score: 144.91 E-value: 9.89e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 329 WLWFIAKPLHTLLSFIQGIVV-NWGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDD----RQRMSQ 403
Cdd:PRK02944 36 WNEYFVYPLSQLITYFANLFGsNYGLAIIVVTLLIRLLILPLMIKQTKSTKAMQALQPEMQKLKEKYSSKdqatQQKLQQ 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 404 EMMELYKKEKVNPLGGCLPIILQMPIFISLYWALMESVELRHSPFFgWItDLSAQDPYYILPLLMGASMFLIQK-MSPTT 482
Cdd:PRK02944 116 EMMQLFQKNGVNPLAGCLPIFIQMPILIAFYHAIMRTSEISKHSFL-WF-DLGQADPYYILPIVAGITTFIQQKlMMAGT 193
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 490873802 483 VTDPMQQKIMTF-MPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLI 528
Cdd:PRK02944 194 AGQNPQMAMMLWlMPIMILIFAINFPAALSLYWVVGNIFMIAQTYLI 240
|
|
| PRK01622 |
PRK01622 |
membrane protein insertase YidC; |
315-534 |
5.86e-38 |
|
membrane protein insertase YidC;
Pssm-ID: 179310 Cd Length: 256 Bit Score: 140.27 E-value: 5.86e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 315 AAVAPNLDLVVDYGWLWFIAKPLHTLLSFIQGIV-VNWGLAIICLTFIVRGAMYPLTKAQYTSM----AKMRMLQPKLTA 389
Cdd:PRK01622 23 CSNAAPIDAHSDGFFDHYFVYPFSFLIQFVAHHIgGSYGIAIIIVTLIIRSLMIPLAVSQYKSQrgmqEKMAVMKPELDK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 390 MRERIG-----DDRQRMSQEMMELYKKEKVNPLG-GCLPIILQMPIFISLYWALMESVELRHSPFFgWItDLSAQDpyYI 463
Cdd:PRK01622 103 IQAKLKvtkdlEKQKEYQKEMMELYKSGNINPLAmGCLPLLIQMPILSAFYYAIRRTEEIASHSFL-WF-NLGHAD--HI 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490873802 464 LPLLMGASMFLIQKMSPTTVTDPMQQ---KIMTFM-PVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRALEK 534
Cdd:PRK01622 179 LPIIAGLTYFIQMKVSQSNGTSPEQVqmlKIQGIMmPAMILFMSFAAPSALVLYWITGGLFLMGQTIVLRKVMER 253
|
|
| PRK03449 |
PRK03449 |
putative inner membrane protein translocase component YidC; Provisional |
329-534 |
1.24e-32 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 179580 Cd Length: 304 Bit Score: 126.72 E-value: 1.24e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 329 WLWfiakplHTLLSFIQGIV--VNWGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDDRQRMSQEMM 406
Cdd:PRK03449 14 WFW------HKLFSFVLGPDngFAWALSVMFLVFTLRALLYKPFVRQIRTTRKMQELQPQIKALQKKYGNDRQKMALEMQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 407 ELYKKEKVNPLGGCLPIILQMPIFISLYWAL--------------MESVELRHSP--FFG-------------------W 451
Cdd:PRK03449 88 KLQKEHGFNPILGCLPMLAQIPVFLGLFHVLrsfnrtgtgfgqlgMSVEENRNTPnyVFSaedvqsfldarlfgaplsaY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 452 ITDLSAQDPYY-----------ILPLLMGASMFL-------IQKMSPTTVTDP---MQQKIMT-FMPVMFTFFFLFFPSG 509
Cdd:PRK03449 168 ITMPRSGLDAFvdftrtniilvGVPLMIIAGVAThfnsrasVARQSAEAAANPqtaMMNKLALwVFPLGVLVGGPFLPLA 247
|
250 260
....*....|....*....|....*
gi 490873802 510 LVLYWLVSNIVTLIQQTLIYRALEK 534
Cdd:PRK03449 248 ILLYWVSNNIWTFGQQHYVFGKIDK 272
|
|
| PRK02654 |
PRK02654 |
putative inner membrane protein translocase component YidC; Provisional |
340-448 |
1.98e-26 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 235058 Cd Length: 375 Bit Score: 110.84 E-value: 1.98e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 340 LLSFIQGIVVNWGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQP----KLTAMRERIGDDRQRMSQEMMELYkKEKVN 415
Cdd:PRK02654 16 ILDFFYGIVPSYGLAIVALTLVIRFALYPLSAGSIRNMRRMKIAQPvmqkRQAEIQERYKNDPQKQQEEMGKLM-KEFGN 94
|
90 100 110
....*....|....*....|....*....|...
gi 490873802 416 PLGGCLPIILQMPIFISLYwalmesVELRHSPF 448
Cdd:PRK02654 95 PLAGCLPLLVQMPILFALF------ATLRGSPF 121
|
|
| PRK02463 |
PRK02463 |
OxaA-like protein precursor; Provisional |
327-528 |
9.70e-26 |
|
OxaA-like protein precursor; Provisional
Pssm-ID: 235040 Cd Length: 307 Bit Score: 107.51 E-value: 9.70e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 327 YGWLW-FIAKPLHTLLS-FIQGIVVNWGLAIICLTFIVRGAMYPLT-----KAQYTSmAKMRMLQPKLTAMRERIGD--- 396
Cdd:PRK02463 34 TGFIWnFLGAPMSYFIDyFANNLGLGFGLAIIIVTIIVRLIILPLGlyqswKATYQS-EKMAYLKPVFEPINERLKNatt 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 397 DRQRMS--QEMMELYKKEKVNPLG--GCLPIILQMPIFISLYWALMESVELRHSPFFGwiTDLSAQDpyYILPLLMGASM 472
Cdd:PRK02463 113 QEEKMAaqTELMAAQRENGISMLGgiGCLPLLIQMPFFSALYFAAQYTKGVSTSTFLG--IDLGSPS--LVLTAIIGVLY 188
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 490873802 473 FLIQKMSPTTVTDPMQQKIMTF---MPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLI 528
Cdd:PRK02463 189 FFQSWLSMMGVPEEQREQMKAMmymMPIMMVVFSFSSPAGVGLYWLVGGFFSIIQQLIT 247
|
|
| YidC_peri |
cd19960 |
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from ... |
66-326 |
2.85e-19 |
|
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Gram-negative bacteria and similar domains; Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contains a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich. Other members of the YidC/Oxa1/Alb3 family include YidC1/YidC2 from gram-positive bacteria as well as eukaryotic members such as mitochondrial Oxa1/Oxa2 (or Cox18) and chloroplastic Alb3/Alb4; they are not part of this hierarchy as they do not possess the periplasmic domain.
Pssm-ID: 410999 Cd Length: 233 Bit Score: 86.92 E-value: 2.85e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 66 ITVTTDVLTLSIDTVGgDVVQANLNDYsaEFDSEDTFVLlknepghQFIAQSGL------VGPQGIDLSSTNRPsYTvsA 139
Cdd:cd19960 3 ATVKSKDFELTIDTLG-RISQFYLKDK--KYKNEDGKQL-------ELISPQAPkpleirFSDPALNEEAFKTP-YT--A 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 140 DSFTLADGQDELRIPMTYQANGLDYTKTFVLKR-GSYAMDVEYDvvnnsgTNATFGMYAHLRQNVMDDggsltMPTYRGG 218
Cdd:cd19960 70 SVSEIDLESGPQSVVLTQTLSGLTVTKTITFYPdGHYDVKVKLS------KPVDYFITPGQRPNAAVD-----SYTVHGA 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 219 AYSTEDTRYKKYSFDDMQDRNLSlnlaNGQGWAAMIQHYFASAWIPRDEAGSNLYTRVIGNlgdigvrmpNKTIATGDEA 298
Cdd:cd19960 139 LVKTADGTITIIEDGDAEGTESF----SNVNIAASFDRYYATLFYNFDKGLNVVVTKDASD---------NPLVFVKGNG 205
|
250 260
....*....|....*....|....*...
gi 490873802 299 SFKATLWVGPKLQDQMAAVAPNLDLVVD 326
Cdd:cd19960 206 NFSLHGYIGPKEYKLLKSIDPELTDVIE 233
|
|
| PRK00247 |
PRK00247 |
putative inner membrane protein translocase component YidC; Validated |
330-535 |
6.06e-18 |
|
putative inner membrane protein translocase component YidC; Validated
Pssm-ID: 178945 [Multi-domain] Cd Length: 429 Bit Score: 86.06 E-value: 6.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 330 LWfiakplHTLLSFIQGI--VVNWGLAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGD-----DRQRMS 402
Cdd:PRK00247 15 LW------HLLLHNVLGLddSLAWFASLFGLVITVRAIIAPFTWQQYKSGRTAAHIRPKRKALREEYKGktdeaSIRELQ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 403 QEMMELYKKEKVNPLGGCLPIILQMPIFISLYWALM---ESVELRHSPFFGWITDLSAQD--------------PYY--- 462
Cdd:PRK00247 89 QKQKDLNKEYGYNPLAGCVPALIQIPVFLGLYQVLLrmaRPEGGLENPVHQPIGFLTSEEvesflqgrvfnvplPAYvsm 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 463 ------------------ILPLLMGASMFLIQKMSPTTVTDPMQ-----------QKIMTFMPVMFTFFFLFF------P 507
Cdd:PRK00247 169 paeqlaylgttqatvlafVLPLFIAAAVFTAINMAMSTYRSFQTndhdsgfavgmLKFLIVMAILAPIFPLSLgltgpfP 248
|
250 260
....*....|....*....|....*...
gi 490873802 508 SGLVLYWLVSNIVTLIQQTLIYRALEKK 535
Cdd:PRK00247 249 TAIALYWVANNLWTLIQNIIMYLILERK 276
|
|
| PRK02201 |
PRK02201 |
putative inner membrane protein translocase component YidC; Provisional |
327-529 |
3.01e-14 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 235012 Cd Length: 357 Bit Score: 74.28 E-value: 3.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 327 YGWL-WFIAK-PLHTLLSFIQGIVVNWG--LAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERIGDD----- 397
Cdd:PRK02201 105 YGLFvYPIAQiILSIMASQSLSELYGWStiLAIIVVVLIIRLISFLITFKSTFNQEKQEELQGKKAKIDAKYKDYkkdkq 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 398 -RQRMSQEMMELYKKEKVNPLGGCLPIILQMPIFISLYWALMESVELRHSPFFG-------WITDLSAQDPYYILPLLMG 469
Cdd:PRK02201 185 mKQRKQQEIQELYKKHNISPFSPFVQMFVTLPIFIAVYRVVQSLPSIKVTTWLGidlsatsWQEIFAGNWIYLPILIIVV 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873802 470 ASMFLIQKM----------SPTTVTDPMQ--------QKIMT----FMPVMftffflfFPSGLVLYWLVSNIVTLIQQTL 527
Cdd:PRK02201 265 PVQALSQLLpqilnkkknkERTLNVKEKEalkkqnktQNIISivfiFFGVI-------FAAGVQIYWIIGGIWTILQTLG 337
|
..
gi 490873802 528 IY 529
Cdd:PRK02201 338 IH 339
|
|
| |
