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Conserved domains on  [gi|490874260|ref|WP_004736261|]
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MULTISPECIES: NAD(P)/FAD-dependent oxidoreductase [Vibrio]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11441299)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to sulfide:quinone oxidoreductase which catalyzes the oxidation of hydrogen sulfide using quinone as the electron acceptor

EC:  1.6.-.-
Gene Ontology:  GO:0003954|GO:0006116
PubMed:  15590775|28181562

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
18-411 1.14e-136

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


:

Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 396.81  E-value: 1.14e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  18 TKLGRTLGrkKRAQITLVDRKASHLWKPLLHEVATGSLDEGVDALSYRAHAKNHYFDFQMGSLNDIDRERKVIALselkd 97
Cdd:COG1252   18 RRLRKKLG--GDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRAGVRFIQGEVTGIDPEARTVTL----- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  98 DHGellmpsRELEYDILVMALGSTSNDFNTPGVRDNCIFLDSPEQAHRFRTEMNNQFLKLHAKNGqgtVDIAIVGAGATG 177
Cdd:COG1252   91 ADG------RTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAERRRL---LTIVVVGGGPTG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 178 VELSAELHNAVKELRTYGfgDLDSSKLNVNLVEAGERILPALPPRISSAAHSELTKLGVTVRTTTMVTQADADGLTTKDG 257
Cdd:COG1252  162 VELAGELAELLRKLLRYP--GIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLEDG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 258 EKIPAQIMVWAAGIKAPDFMKDIGgLETNRINQLVVKNTLQTTLDDNIFAIGDLAQCTQADGSFVPPRAQAAHQMASCAF 337
Cdd:COG1252  240 EEIPADTVIWAAGVKAPPLLADLG-LPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVPDPDGKPVPKTAQAAVQQAKVLA 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490874260 338 SNIIAKLNGRDLKDYIYKDKGSLVSLSRFSTVGSLMGnltkgsMMVEGRIARIVYISLYRMHQMALHGLIKTSL 411
Cdd:COG1252  319 KNIAALLRGKPLKPFRYRDKGCLASLGRGAAVADVGG------LKLSGFLAWLLKRAIHLYFLPGFRGRLRVLL 386
 
Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
18-411 1.14e-136

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 396.81  E-value: 1.14e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  18 TKLGRTLGrkKRAQITLVDRKASHLWKPLLHEVATGSLDEGVDALSYRAHAKNHYFDFQMGSLNDIDRERKVIALselkd 97
Cdd:COG1252   18 RRLRKKLG--GDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRAGVRFIQGEVTGIDPEARTVTL----- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  98 DHGellmpsRELEYDILVMALGSTSNDFNTPGVRDNCIFLDSPEQAHRFRTEMNNQFLKLHAKNGqgtVDIAIVGAGATG 177
Cdd:COG1252   91 ADG------RTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAERRRL---LTIVVVGGGPTG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 178 VELSAELHNAVKELRTYGfgDLDSSKLNVNLVEAGERILPALPPRISSAAHSELTKLGVTVRTTTMVTQADADGLTTKDG 257
Cdd:COG1252  162 VELAGELAELLRKLLRYP--GIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLEDG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 258 EKIPAQIMVWAAGIKAPDFMKDIGgLETNRINQLVVKNTLQTTLDDNIFAIGDLAQCTQADGSFVPPRAQAAHQMASCAF 337
Cdd:COG1252  240 EEIPADTVIWAAGVKAPPLLADLG-LPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVPDPDGKPVPKTAQAAVQQAKVLA 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490874260 338 SNIIAKLNGRDLKDYIYKDKGSLVSLSRFSTVGSLMGnltkgsMMVEGRIARIVYISLYRMHQMALHGLIKTSL 411
Cdd:COG1252  319 KNIAALLRGKPLKPFRYRDKGCLASLGRGAAVADVGG------LKLSGFLAWLLKRAIHLYFLPGFRGRLRVLL 386
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 26-333 2.42e-41

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 148.62  E-value: 2.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260   26 RKKRAQITLV-DRKASHLWKPLLHEVATGSLDEGVDAL---SYRAHAKNHYFDFQMG---SLN----DIDRERKVIALSE 94
Cdd:pfam07992  20 AQLGGKVTLIeDEGTCPYGGCVLSKALLGAAEAPEIASlwaDLYKRKEEVVKKLNNGievLLGtevvSIDPGAKKVVLEE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260   95 LKDDHGEllmpsrELEYDILVMALGSTSNDFNTPGVRDNCIFLDspeqahrfRTEMNNQFLKLHAKNGqgtvDIAIVGAG 174
Cdd:pfam07992 100 LVDGDGE------TITYDRLVIATGARPRLPPIPGVELNVGFLV--------RTLDSAEALRLKLLPK----RVVVVGGG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  175 ATGVELSAELHNAVKElrtygfgdldssklnVNLVEAGERILPALPPRISSAAHSELTKLGVTVRTTTMVTQADADG--- 251
Cdd:pfam07992 162 YIGVELAAALAKLGKE---------------VTLIEALDRLLRAFDEEISAALEKALEKNGVEVRLGTSVKEIIGDGdgv 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  252 -LTTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNRINQLVVKNTLQTTlDDNIFAIGDLAQctqadgsFVPPRAQAAH 330
Cdd:pfam07992 227 eVILKDGTEIDADLVVVAIGRRPNTELLEAAGLELDERGGIVVDEYLRTS-VPGIYAAGDCRV-------GGPELAQNAV 298


                  ...
gi 490874260  331 QMA 333
Cdd:pfam07992 299 AQG 301
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 28-396 1.37e-31

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 124.88  E-value: 1.37e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  28 KRAQITLVDRKASHLWKPLLHEVATGSLD-----EGVDalSYRAHAKNHYFDfqmGSLNDIDRERKVIaLSELKDDHGEL 102
Cdd:PTZ00318  32 KKYNITVISPRNHMLFTPLLPQTTTGTLEfrsicEPVR--PALAKLPNRYLR---AVVYDVDFEEKRV-KCGVVSKSNNA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 103 LMPSRELEYDILVMALGSTSNDFNTPGVRDNCIFLDSPEQAHRFRTEMNNQFLKlhAKNGQGTVDIA-------IVGAGA 175
Cdd:PTZ00318 106 NVNTFSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIER--ASLPTTSVEERkrllhfvVVGGGP 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 176 TGVELSAELHNAVKElrtygfgdlDSSKLN--------VNLVEAGERILPALPPRISSAAHSELTKLGVTVRTTTMVTQA 247
Cdd:PTZ00318 184 TGVEFAAELADFFRD---------DVRNLNpelveeckVTVLEAGSEVLGSFDQALRKYGQRRLRRLGVDIRTKTAVKEV 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 248 DADGLTTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNRiNQLVVKNTLQTTLDDNIFAIGDlaqCTQADGSFVPPRAQ 327
Cdd:PTZ00318 255 LDKEVVLKDGEVIPTGLVVWSTGVGPGPLTKQLKVDKTSR-GRISVDDHLRVKPIPNVFALGD---CAANEERPLPTLAQ 330

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 328 AAHQMASCAFSNIIAKLNGRDL-KDYIYKDKGSLVSLSRFSTVGSLmgnltkGSMMVEGRIARIVYISLY 396
Cdd:PTZ00318 331 VASQQGVYLAKEFNNELKGKPMsKPFVYRSLGSLAYLGNYSAIVQL------GAFDLSGFKALLFWRSAY 394
nitri_red_nirB TIGR02374
nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen ...
 83-313 1.95e-07

nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 162827 [Multi-domain]  Cd Length: 785  Bit Score: 53.29  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260   83 IDRERKVIALSElkddhgellmpSRELEYDILVMALGSTSNDFNTPGVrdnciflDSPEqAHRFRTEMNNQFLKLHAKNG 162
Cdd:TIGR02374  80 IDTDQKQVITDA-----------GRTLSYDKLILATGSYPFILPIPGA-------DKKG-VYVFRTIEDLDAIMAMAQRF 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  163 QgtvDIAIVGAGATGVElsaelhnAVKELRTYGfgdldsskLNVNLVEAGERILPAlppRISSAA----HSELTKLGVT- 237
Cdd:TIGR02374 141 K---KAAVIGGGLLGLE-------AAVGLQNLG--------MDVSVIHHAPGLMAK---QLDQTAgrllQRELEQKGLTf 199

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490874260  238 --VRTTTMVTQAD-ADGLTTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNRinQLVVKNTLQTTlDDNIFAIGDLAQ 313
Cdd:TIGR02374 200 llEKDTVEIVGATkADRIRFKDGSSLEADLIVMAAGIRPNDELAVSAGIKVNR--GIIVNDSMQTS-DPDIYAVGECAE 275
 
Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
18-411 1.14e-136

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 396.81  E-value: 1.14e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  18 TKLGRTLGrkKRAQITLVDRKASHLWKPLLHEVATGSLDEGVDALSYRAHAKNHYFDFQMGSLNDIDRERKVIALselkd 97
Cdd:COG1252   18 RRLRKKLG--GDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRAGVRFIQGEVTGIDPEARTVTL----- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  98 DHGellmpsRELEYDILVMALGSTSNDFNTPGVRDNCIFLDSPEQAHRFRTEMNNQFLKLHAKNGqgtVDIAIVGAGATG 177
Cdd:COG1252   91 ADG------RTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAERRRL---LTIVVVGGGPTG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 178 VELSAELHNAVKELRTYGfgDLDSSKLNVNLVEAGERILPALPPRISSAAHSELTKLGVTVRTTTMVTQADADGLTTKDG 257
Cdd:COG1252  162 VELAGELAELLRKLLRYP--GIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLEDG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 258 EKIPAQIMVWAAGIKAPDFMKDIGgLETNRINQLVVKNTLQTTLDDNIFAIGDLAQCTQADGSFVPPRAQAAHQMASCAF 337
Cdd:COG1252  240 EEIPADTVIWAAGVKAPPLLADLG-LPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVPDPDGKPVPKTAQAAVQQAKVLA 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490874260 338 SNIIAKLNGRDLKDYIYKDKGSLVSLSRFSTVGSLMGnltkgsMMVEGRIARIVYISLYRMHQMALHGLIKTSL 411
Cdd:COG1252  319 KNIAALLRGKPLKPFRYRDKGCLASLGRGAAVADVGG------LKLSGFLAWLLKRAIHLYFLPGFRGRLRVLL 386
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 26-333 2.42e-41

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 148.62  E-value: 2.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260   26 RKKRAQITLV-DRKASHLWKPLLHEVATGSLDEGVDAL---SYRAHAKNHYFDFQMG---SLN----DIDRERKVIALSE 94
Cdd:pfam07992  20 AQLGGKVTLIeDEGTCPYGGCVLSKALLGAAEAPEIASlwaDLYKRKEEVVKKLNNGievLLGtevvSIDPGAKKVVLEE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260   95 LKDDHGEllmpsrELEYDILVMALGSTSNDFNTPGVRDNCIFLDspeqahrfRTEMNNQFLKLHAKNGqgtvDIAIVGAG 174
Cdd:pfam07992 100 LVDGDGE------TITYDRLVIATGARPRLPPIPGVELNVGFLV--------RTLDSAEALRLKLLPK----RVVVVGGG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  175 ATGVELSAELHNAVKElrtygfgdldssklnVNLVEAGERILPALPPRISSAAHSELTKLGVTVRTTTMVTQADADG--- 251
Cdd:pfam07992 162 YIGVELAAALAKLGKE---------------VTLIEALDRLLRAFDEEISAALEKALEKNGVEVRLGTSVKEIIGDGdgv 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  252 -LTTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNRINQLVVKNTLQTTlDDNIFAIGDLAQctqadgsFVPPRAQAAH 330
Cdd:pfam07992 227 eVILKDGTEIDADLVVVAIGRRPNTELLEAAGLELDERGGIVVDEYLRTS-VPGIYAAGDCRV-------GGPELAQNAV 298


                  ...
gi 490874260  331 QMA 333
Cdd:pfam07992 299 AQG 301
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 28-396 1.37e-31

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 124.88  E-value: 1.37e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  28 KRAQITLVDRKASHLWKPLLHEVATGSLD-----EGVDalSYRAHAKNHYFDfqmGSLNDIDRERKVIaLSELKDDHGEL 102
Cdd:PTZ00318  32 KKYNITVISPRNHMLFTPLLPQTTTGTLEfrsicEPVR--PALAKLPNRYLR---AVVYDVDFEEKRV-KCGVVSKSNNA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 103 LMPSRELEYDILVMALGSTSNDFNTPGVRDNCIFLDSPEQAHRFRTEMNNQFLKlhAKNGQGTVDIA-------IVGAGA 175
Cdd:PTZ00318 106 NVNTFSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIER--ASLPTTSVEERkrllhfvVVGGGP 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 176 TGVELSAELHNAVKElrtygfgdlDSSKLN--------VNLVEAGERILPALPPRISSAAHSELTKLGVTVRTTTMVTQA 247
Cdd:PTZ00318 184 TGVEFAAELADFFRD---------DVRNLNpelveeckVTVLEAGSEVLGSFDQALRKYGQRRLRRLGVDIRTKTAVKEV 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 248 DADGLTTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNRiNQLVVKNTLQTTLDDNIFAIGDlaqCTQADGSFVPPRAQ 327
Cdd:PTZ00318 255 LDKEVVLKDGEVIPTGLVVWSTGVGPGPLTKQLKVDKTSR-GRISVDDHLRVKPIPNVFALGD---CAANEERPLPTLAQ 330

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 328 AAHQMASCAFSNIIAKLNGRDL-KDYIYKDKGSLVSLSRFSTVGSLmgnltkGSMMVEGRIARIVYISLY 396
Cdd:PTZ00318 331 VASQQGVYLAKEFNNELKGKPMsKPFVYRSLGSLAYLGNYSAIVQL------GAFDLSGFKALLFWRSAY 394
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 26-343 3.20e-24

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 102.20  E-value: 3.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  26 RKKRAQITLVDRKASH------LWKPLLHEVATgsldegVDALSYRAHAKnhyF-----DFQMGSL-NDIDRERKVIals 93
Cdd:COG0446    2 LGPDAEITVIEKGPHHsyqpcgLPYYVGGGIKD------PEDLLVRTPES---FerkgiDVRTGTEvTAIDPEAKTV--- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  94 ELKDDhgellmpsRELEYDILVMALGSTSNDFNTPGVRDNCIF-LDSPEQAHRFRTemnnqflKLHAKNGQgtvDIAIVG 172
Cdd:COG0446   70 TLRDG--------ETLSYDKLVLATGARPRPPPIPGLDLPGVFtLRTLDDADALRE-------ALKEFKGK---RAVVIG 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 173 AGATGVELSAELHNAvkelrtygfgdldssKLNVNLVEAGERILPALPPRISSAAHSELTKLGVTVRTTTMVTQADADG- 251
Cdd:COG0446  132 GGPIGLELAEALRKR---------------GLKVTLVERAPRLLGVLDPEMAALLEEELREHGVELRLGETVVAIDGDDk 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 252 --LTTKDGEKIPAQIMVWAAGIkAPDF--MKDIgGLETNRINQLVVKNTLQTTlDDNIFAIGDLAQCTQADGS--FVPPR 325
Cdd:COG0446  197 vaVTLTDGEEIPADLVVVAPGV-RPNTelAKDA-GLALGERGWIKVDETLQTS-DPDVYAAGDCAEVPHPVTGktVYIPL 273

                        330
                 ....*....|....*...
gi 490874260 326 AQAAHQMASCAFSNIIAK 343
Cdd:COG0446  274 ASAANKQGRVAAENILGG 291
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
83-340 5.26e-20

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 91.36  E-value: 5.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  83 IDRERKVIalselKDDHGEllmpsrELEYDILVMALGSTSNDFNTPGV-RDNCIFLDSPEQAHRFRTemnnqflklHAKN 161
Cdd:COG1251   82 IDRAARTV-----TLADGE------TLPYDKLVLATGSRPRVPPIPGAdLPGVFTLRTLDDADALRA---------ALAP 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 162 GQgtvDIAIVGAGATGVELSAELHNAvkelrtygfgdldssKLNVNLVEAGERILP-ALPPRISSAAHSELTKLG----V 236
Cdd:COG1251  142 GK---RVVVIGGGLIGLEAAAALRKR---------------GLEVTVVERAPRLLPrQLDEEAGALLQRLLEALGvevrL 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 237 TVRTTTMVTQADADGLTTKDGEKIPAQIMVWAAGIKaP--DFMKDIgGLETNR-InqlVVKNTLQTTlDDNIFAIGDLAQ 313
Cdd:COG1251  204 GTGVTEIEGDDRVTGVRLADGEELPADLVVVAIGVR-PntELARAA-GLAVDRgI---VVDDYLRTS-DPDIYAAGDCAE 277

                        250       260
                 ....*....|....*....|....*...
gi 490874260 314 CT-QADGSFVPPRAQAAHQMASCAFSNI 340
Cdd:COG1251  278 HPgPVYGRRVLELVAPAYEQARVAAANL 305
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
168-313 5.11e-11

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 63.78  E-value: 5.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 168 IAIVGAGATGVELSAELHNAVKElrtygfgdldssklnVNLVEAGERILPAL-PPRISSAAHSELTKLGVTVRTTTMVTQ 246
Cdd:PRK04965 144 VLVVGGGLIGTELAMDLCRAGKA---------------VTLVDNAASLLASLmPPEVSSRLQHRLTEMGVHLLLKSQLQG 208

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490874260 247 AD--ADGL--TTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNRinQLVVKNTLQTTlDDNIFAIGDLAQ 313
Cdd:PRK04965 209 LEktDSGIraTLDSGRSIEVDAVIAAAGLRPNTALARRAGLAVNR--GIVVDSYLQTS-APDIYALGDCAE 276
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 168-312 1.65e-10

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 62.41  E-value: 1.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 168 IAIVGAGATGVELsAELHNAvkelrtygFGdldsSKlnVNLVEAGERILPALPPRISSAAHSELTKLGVTVRTTTMVTQA 247
Cdd:COG1249  171 LVVIGGGYIGLEF-AQIFAR--------LG----SE--VTLVERGDRLLPGEDPEISEALEKALEKEGIDILTGAKVTSV 235

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490874260 248 DADG----LTTKDGEK---IPAQIMVWAAGIKApdFMKDIG----GLETNRINQLVVKNTLQTTlDDNIFAIGDLA 312
Cdd:COG1249  236 EKTGdgvtVTLEDGGGeeaVEADKVLVATGRRP--NTDGLGleaaGVELDERGGIKVDEYLRTS-VPGIYAIGDVT 308
nitri_red_nirB TIGR02374
nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen ...
 83-313 1.95e-07

nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 162827 [Multi-domain]  Cd Length: 785  Bit Score: 53.29  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260   83 IDRERKVIALSElkddhgellmpSRELEYDILVMALGSTSNDFNTPGVrdnciflDSPEqAHRFRTEMNNQFLKLHAKNG 162
Cdd:TIGR02374  80 IDTDQKQVITDA-----------GRTLSYDKLILATGSYPFILPIPGA-------DKKG-VYVFRTIEDLDAIMAMAQRF 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  163 QgtvDIAIVGAGATGVElsaelhnAVKELRTYGfgdldsskLNVNLVEAGERILPAlppRISSAA----HSELTKLGVT- 237
Cdd:TIGR02374 141 K---KAAVIGGGLLGLE-------AAVGLQNLG--------MDVSVIHHAPGLMAK---QLDQTAgrllQRELEQKGLTf 199

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490874260  238 --VRTTTMVTQAD-ADGLTTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNRinQLVVKNTLQTTlDDNIFAIGDLAQ 313
Cdd:TIGR02374 200 llEKDTVEIVGATkADRIRFKDGSSLEADLIVMAAGIRPNDELAVSAGIKVNR--GIIVNDSMQTS-DPDIYAVGECAE 275
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
168-310 4.08e-07

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 52.08  E-value: 4.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 168 IAIVGAGATGVElsaelhnavkelrtYG--FGDLDsskLNVNLVEAGERILPALPPRISSAAHSELTKLGVTVRTTTMVT 245
Cdd:PRK05249 178 LIIYGAGVIGCE--------------YAsiFAALG---VKVTLINTRDRLLSFLDDEISDALSYHLRDSGVTIRHNEEVE 240

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490874260 246 Q--ADADG--LTTKDGEKIPAQIMVWAAGIKAPdfMKDIG----GLETNRINQLVVKNTLQTTLdDNIFAIGD 310
Cdd:PRK05249 241 KveGGDDGviVHLKSGKKIKADCLLYANGRTGN--TDGLNlenaGLEADSRGQLKVNENYQTAV-PHIYAVGD 310
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 168-235 1.07e-05

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 43.35  E-value: 1.07e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490874260  168 IAIVGAGATGVELSAELHNAVKElrtygfgdldssklnVNLVEAGERILPALPPRISSAAHSELTKLG 235
Cdd:pfam00070   2 VVVVGGGYIGLELAGALARLGSK---------------VTVVERRDRLLPGFDPEIAKILQEKLEKNG 54
PRK07251 PRK07251
FAD-containing oxidoreductase;
60-311 2.13e-05

FAD-containing oxidoreductase;


Pssm-ID: 180907 [Multi-domain]  Cd Length: 438  Bit Score: 46.67  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  60 DALSYRAHAKNhyfdFQMGSLNDIDR--------ERKVIALSELKDdhgellmpSRELEYDILVMALGSTSNDFNTPGVR 131
Cdd:PRK07251  72 NTVTSRLRGKN----YAMLAGSGVDLydaeahfvSNKVIEVQAGDE--------KIELTAETIVINTGAVSNVLPIPGLA 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 132 DNCIFLDSpeqahrfrTEMnnQFLKLHAKNgqgtvdIAIVGAGATGVELsAELHNAVkelrtygfgdldSSKlnVNLVEA 211
Cdd:PRK07251 140 DSKHVYDS--------TGI--QSLETLPER------LGIIGGGNIGLEF-AGLYNKL------------GSK--VTVLDA 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 212 GERILPALPPRISSAAHSELTKLGVTVRTTTMVTQADADG---LTTKDGEKIPAQIMVWAAGIKAPdfMKDIgGLETNRI 288
Cdd:PRK07251 189 ASTILPREEPSVAALAKQYMEEDGITFLLNAHTTEVKNDGdqvLVVTEDETYRFDALLYATGRKPN--TEPL-GLENTDI 265

                        250       260
                 ....*....|....*....|....*...
gi 490874260 289 -----NQLVVKNTLQTTLdDNIFAIGDL 311
Cdd:PRK07251 266 elterGAIKVDDYCQTSV-PGVFAVGDV 292
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 111-312 2.96e-05

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 46.19  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 111 YDILVMALGSTSNDFNTPGVR-DNCIFLDSPEQAHRFRTEMNNQFLKlhakngqgtvDIAIVGAGATGVELSAELHNAVK 189
Cdd:PRK09564 104 YDKLMIATGARPIIPPIKNINlENVYTLKSMEDGLALKELLKDEEIK----------NIVIIGAGFIGLEAVEAAKHLGK 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 190 elrtygfgdldssklNVNLVEAGERILP-ALPPRISSAAHSELTKLGVTVRTTTMVTQADAD----GLTTKDGEkIPAQI 264
Cdd:PRK09564 174 ---------------NVRIIQLEDRILPdSFDKEITDVMEEELRENGVELHLNEFVKSLIGEdkveGVVTDKGE-YEADV 237

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 490874260 265 MVWAAGIK-APDFMKDiGGLETNRINQLVVKNTLQTTlDDNIFAIGDLA 312
Cdd:PRK09564 238 VIVATGVKpNTEFLED-TGLKTLKNGAIIVDEYGETS-IENIYAAGDCA 284
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 168-310 3.15e-05

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 45.94  E-value: 3.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 168 IAIVGAGATGVEL-SAelhnavkeLRTYGfgdldsSKlnVNLVEAGERILPALPPRISSAAHSELTK----------LGV 236
Cdd:PRK06292 172 LAVIGGGVIGLELgQA--------LSRLG------VK--VTVFERGDRILPLEDPEVSKQAQKILSKefkiklgakvTSV 235

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490874260 237 TVRTTTMVTQADADGlttkDGEKIPAQIMVWAAGIKA--PDFMKDIGGLETNRINQLVVKNTLQTTlDDNIFAIGD 310
Cdd:PRK06292 236 EKSGDEKVEELEKGG----KTETIEADYVLVATGRRPntDGLGLENTGIELDERGRPVVDEHTQTS-VPGIYAAGD 306
PRK09754 PRK09754
phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
 81-312 1.96e-04

phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional


Pssm-ID: 170080 [Multi-domain]  Cd Length: 396  Bit Score: 43.38  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260  81 NDIDRERKVIALSELKDDHGELLMPSRELEYDILVMALGSTSNDFNT-PGVRDNCIFLDSPEQAHRFRtemnnQFLKLHA 159
Cdd:PRK09754  71 NNVHLHSGVTIKTLGRDTRELVLTNGESWHWDQLFIATGAAARPLPLlDALGERCFTLRHAGDAARLR-----EVLQPER 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 160 KngqgtvdIAIVGAGATGVELSAelhnAVKELRTygfgdldssklNVNLVEAGERIL----PALPPRISSAAHSELTKLG 235
Cdd:PRK09754 146 S-------VVIVGAGTIGLELAA----SATQRRC-----------KVTVIELAATVMgrnaPPPVQRYLLQRHQQAGVRI 203

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490874260 236 VTVRTTTMVTQADADGLTTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNriNQLVVKNTLQTTlDDNIFAIGDLA 312
Cdd:PRK09754 204 LLNNAIEHVVDGEKVELTLQSGETLQADVVIYGIGISANDQLAREANLDTA--NGIVIDEACRTC-DPAIFAGGDVA 277
PRK06116 PRK06116
glutathione reductase; Validated
 168-310 5.01e-04

glutathione reductase; Validated


Pssm-ID: 235701 [Multi-domain]  Cd Length: 450  Bit Score: 42.07  E-value: 5.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 168 IAIVGAGATGVELSAELHnavkelrtyGFGdldsskLNVNLVEAGERILPALPPRISSAAHSELTKLGVTVRTTTMVTQ- 246
Cdd:PRK06116 170 VAVVGAGYIAVEFAGVLN---------GLG------SETHLFVRGDAPLRGFDPDIRETLVEEMEKKGIRLHTNAVPKAv 234

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490874260 247 -ADADG---LTTKDGEKIPAQIMVWAAGiKAPDfMKDIG----GLETNRINQLVVkNTLQTTLDDNIFAIGD 310
Cdd:PRK06116 235 eKNADGsltLTLEDGETLTVDCLIWAIG-REPN-TDGLGlenaGVKLNEKGYIIV-DEYQNTNVPGIYAVGD 303
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 168-312 5.24e-04

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 42.06  E-value: 5.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490874260 168 IAIVGAGATGVELSAELHNavkelrtygFGdldsSKlnVNLVEAGERILPALPPRISSAAHSELTKLGVTVRTTTMVTQA 247
Cdd:PRK06416 175 LVVIGGGYIGVEFASAYAS---------LG----AE--VTIVEALPRILPGEDKEISKLAERALKKRGIKIKTGAKAKKV 239

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490874260 248 --DADG--LTTKDGEK---IPAQIMVWAAGIkAPDfMKDIG----GLETNRiNQLVVKNTLQTTLdDNIFAIGDLA 312
Cdd:PRK06416 240 eqTDDGvtVTLEDGGKeetLEADYVLVAVGR-RPN-TENLGleelGVKTDR-GFIEVDEQLRTNV-PNIYAIGDIV 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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