NCBI Conserved Domain Search

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

1097-2338

0e+00

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 785.20 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1097 NSTILPLLPLQKGMLFLSQVENQSNYNAFTRLSLNGDIDPVRLQQALITVLKRHPQLGGHFDSELAEEPVFIYSLHPTQA 1176
Cdd:COG1020    15 AAPLPLSAAQQRLWLLLLLLLGSAAYNLALALLLLGLLLVAALLLLAALLARRRRALRTRLRTRAGRPVQVIQPVVAAPL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1177 WPVQFCSVTPDL----LEQTIQEALQQPIHLDQPyGLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYQQ- 1251
Cdd:COG1020    95 PVVVLLVDLEALaeaaAEAAAAAEALAPFDLLRG-PLLRLLLLLLLLLLLLLLLALHHIISDGLSDGLLLAELLRLYLAa 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1252 -TNQQLPVLE------HSYETVIKALSGRDHETSKVIWQRDLADLQPLILFNQAQQAVQETSYR-------LSAELGAKL 1317
Cdd:COG1020   174 yAGAPLPLPPlpiqyaDYALWQREWLQGEELARQLAYWRQQLAGLPPLLELPTDRPRPAVQSYRgarvsfrLPAELTAAL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1318 QHKLRQQGITLNVFMQMIWAMTLNIYAHREDIVFGTPVSGRSAPinGLEQQIGLFLNTIPVRVKLNMQQTLWEQLPQLQQ 1397
Cdd:COG1020   254 RALARRHGVTLFMVLLAAFALLLARYSGQDDVVVGTPVAGRPRP--ELEGLVGFFVNTLPLRVDLSGDPSFAELLARVRE 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1398 LHVEHLEHDGLGLSAIQQLI------AQGNLFDSLLVVENYPDNQylqQKLGDAAISKLT-NRGYSHYPLALLVIP-DHQ 1469
Cdd:COG1020   332 TLLAAYAHQDLPFERLVEELqperdlSRNPLFQVMFVLQNAPADE---LELPGLTLEPLElDSGTAKFDLTLTVVEtGDG 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1470 IELLLE-QRGVIDQP--EHFLERMIQLIEIALNEPETSLSHYRLQLAEEHD-LIQKTNQTQ-YYVRQSTLQQLLREQARI 1544
Cdd:COG1020   409 LRLTLEyNTDLFDAAtiERMAGHLVTLLEALAADPDQPLGDLPLLTAAERQqLLAEWNATAaPYPADATLHELFEAQAAR 488

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1545 TPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFM 1624
Cdd:COG1020   489 TPDAVAVVFGDQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGAAYVPLDPAYPAERLAYM 568

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1625 LQDAKSKLVIGEQKDLAAIVHPSIATFAFNELfdetkvDLSSYKTT----VITPQHPAYLIYTSGTTGQPKGVMVSHQAI 1700
Cdd:COG1020   569 LEDAGARLVLTQSALAARLPELGVPVLALDAL------ALAAEPATnppvPVTPDDLAYVIYTSGSTGRPKGVMVEHRAL 642

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1701 VNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSMLAVF 1780
Cdd:COG1020   643 VNLLAWMQRRYGLGPGDRVLQFASLSFDASVWEIFGALLSGATLVLAPPEARRDPAALAELLARHRVTVLNLTPSLLRAL 722

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1781 ENAATEILSSAQrqslpicRVFCSGEALPTALAKSFTEHFS-CELHNLYGPTEAAVDVSYMDATLGLHPEEScVAIGYPV 1859
Cdd:COG1020   723 LDAAPEALPSLR-------LVLVGGEALPPELVRRWRARLPgARLVNLYGPTETTVDSTYYEVTPPDADGGS-VPIGRPI 794

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1860 WNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFT-AGQRMYRTGDIARWHADGSIQYIGRADD 1938
Cdd:COG1020   795 ANTRVYVLDAHLQPVPVGVPGELYIGGAGLARGYLNRPELTAERFVADPFGfPGARLYRTGDLARWLPDGNLEFLGRADD 874

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1939 QLKIRGQRIELGEIEQQLRLISGL-DVVVHAIssEQNKANVQLVAYL--QTTAPVDIDQLKKQLAKHLPAYMVPTHYMLV 2015
Cdd:COG1020   875 QVKIRGFRIELGEIEAALLQHPGVrEAVVVAR--EDAPGDKRLVAYVvpEAGAAAAAALLRLALALLLPPYMVPAAVVLL 952

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2016 EQFPLSHNGKLDRKALPQPHLTPSNTEKQYATSAFEHELTRIFQQILNTDqnIGVNEDFFAIGGHSILVMKLAIEIRKVF 2095
Cdd:COG1020   953 LPLPLTGNGKLDRLALPAPAAAAAAAAAAPPAEEEEEEAALALLLLLVVV--VGDDDFFFFGGGLGLLLLLALARAARLL 1030

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2096 KRTIPIGQLMSHVTIQRLAALLLTQERLAEVEQTGMQPILPIRsgsghPLFCFYPGSGSAWQYTVLNRYLHSDLPIIGLQ 2175
Cdd:COG1020  1031 LLLLLLLLLFLAAAAAAAAAAAAAAAAAAAAPLAAAAAPLPLP-----PLLLSLLALLLALLLLLALLALLALLLLLLLL 1105

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2176 SPRPDGLLANSTDMDELVEKQLEIMRKQQPTGPYTLLGYSLGGTVAYAVAAKLTEQGEKVDylgLLDTYPAEIHQWLDLS 2255
Cdd:COG1020  1106 LLLLALLLLLALLLALLAALRARRAVRQEGPRLRLLVALAAALALAALLALLLAAAAAAAE---LLAAAALLLLLALLLL 1182

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2256 VEEMNAEAEQEQLQFFNDILADADSALSEETRRLQEDIFANYRDAVRLLKPYKMPHFDGELHLVVAEKDLLPYIQPEQQW 2335
Cdd:COG1020  1183 ALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLAAAAAALLALALLLALLALAALLALAALAALAAALLAL 1262


                  ...
gi 490930577 2336 SPL 2338
Cdd:COG1020  1263 ALA 1265

EntF

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

133-1340

0e+00

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 621.49 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  133 LFRQVLFTTHDKVYW-YQRYHHIMLDGFSMINLTKRIVELYQQLQEGKDLSVSP-FIGVNEVISERQAYENSHQFKIDQA 210
Cdd:COG1020   130 LLRLLLLLLLLLLLLlLLALHHIISDGLSDGLLLAELLRLYLAAYAGAPLPLPPlPIQYADYALWQREWLQGEELARQLA 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  211 FWKAYCEDLPSPISLSTHHL-AAKTTATFVKHQLRFSTGILEQIQALAAQTKLALNDMMMSLSLHYIYKMTDKAELVNGI 289
Cdd:COG1020   210 YWRQQLAGLPPLLELPTDRPrPAVQSYRGARVSFRLPAELTAALRALARRHGVTLFMVLLAAFALLLARYSGQDDVVVGT 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  290 PFMRRLGSkAIRSTL-PTVNVLPVKFKVAEKDSWVSLAQHVQEQLREIRPHQKYDAEQILRDLNSIDIHERM--YGPILN 366
Cdd:COG1020   290 PVAGRPRP-ELEGLVgFFVNTLPLRVDLSGDPSFAELLARVRETLLAAYAHQDLPFERLVEELQPERDLSRNplFQVMFV 368

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  367 YKAFDQD-LVIDGEKVKTHHISTG-PIDDFEFSFIVQDHELIIELRADSQRYTQDELFNHGQRLTLLLEQALIRPEQPCS 444
Cdd:COG1020   369 LQNAPADeLELPGLTLEPLELDSGtAKFDLTLTVVETGDGLRLTLEYNTDLFDAATIERMAGHLVTLLEALAADPDQPLG 448

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  445 NFNITTPQELTALTQSGIGPRVSHPEQyNNVLDIFYEQVKKYPERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGA 524
Cdd:COG1020   449 DLPLLTAAERQQLLAEWNATAAPYPAD-ATLHELFEAQAARTPDAVAVVFGD----QSLTYAELNARANRLAHHLRALGV 523

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  525 RKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRMQMMCEDANPLFVLTTQALAQQLPQ-NIQQLHLDQEgvq 603
Cdd:COG1020   524 GPGDLVGVCLERSLEMVVALLAVLKAGAAYVPLDPAYPAERLAYMLEDAGARLVLTQSALAARLPElGVPVLALDAL--- 600

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  604 tQIRKQDASDIPAENRKfdfQDVAYVIFTSGSTGRPKGVMNTHGSLLNLILSHkptiywpvleavNERFPDRP-LRAAHT 682
Cdd:COG1020   601 -ALAAEPATNPPVPVTP---DDLAYVIYTSGSTGRPKGVMVEHRALVNLLAWM------------QRRYGLGPgDRVLQF 664

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  683 HSFSFDSSWLQVFWMLW-GQELHIFDENMRRDAFGLVQEIQQRQIDTLDLPPSFCAQMMTNGLfvENQHHPSLILIGGEA 761
Cdd:COG1020   665 ASLSFDASVWEIFGALLsGATLVLAPPEARRDPAALAELLARHRVTVLNLTPSLLRALLDAAP--EALPSLRLVLVGGEA 742

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  762 APLALWQQLNAQ-PALFAHNLYGPTEYTVDT----FRAELKQTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGF 836
Cdd:COG1020   743 LPPELVRRWRARlPGARLVNLYGPTETTVDStyyeVTPPDADGGSVPIGRPIANTRVYVLDAHLQPVPVGVPGELYIGGA 822

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  837 GIANGYLGRADLSAARFVANPF-EHGQRMYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAV 915
Cdd:COG1020   823 GLARGYLNRPELTAERFVADPFgFPGARLYRTGDLARWLPDGNLEFLGRADDQVKIRGFRIELGEIEAALLQHPGVREAV 902

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  916 VIAEPINNSHRLLGYCVVkdielDEKTSEQLSQQYLSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALPKPQIRAHS 995
Cdd:COG1020   903 VVAREDAPGDKRLVAYVV-----PEAGAAAAAALLRLALALLLPPYMVPAAVVLLLPLPLTGNGKLDRLALPAPAAAAAA 977

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  996 RMAETPEQQLLCQITASVLKL---DAIGIDDDFFMTGGDSISAIMLCTQLRQRGYSLRPSDVFQFKTVAAMAPQLTRLDE 1072
Cdd:COG1020   978 AAAAPPAEEEEEEAALALLLLlvvVVGDDDFFFFGGGLGLLLLLALARAARLLLLLLLLLLLFLAAAAAAAAAAAAAAAA 1057

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1073 QQAAVSKPLFSADLEQKVQEKYGKNSTILPLLPLQKGMLFLSQVENQSNYNAFTRLSLNGDIDPVRLQQALITVLKRHPQ 1152
Cdd:COG1020  1058 AAAAPLAAAAAPLPLPPLLLSLLALLLALLLLLALLALLALLLLLLLLLLLLALLLLLALLLALLAALRARRAVRQEGPR 1137

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1153 LGGHFDSELAEEPVFIYSLHPTQAWPVQfcsvtpdLLEQTIQEALQQPIHLDQPYGLIRATLIQHAPEQSELLIMVHHLL 1232
Cdd:COG1020  1138 LRLLVALAAALALAALLALLLAAAAAAA-------ELLAAAALLLLLALLLLALLLLLLLLLLLLLLLLLLLLLLLLLLL 1210

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1233 TDGWSTPLFLQDFIKAYQQTNQQLPVLEHSYETVI----------KALSGRDHETSKVIWQRDLADLQPLILFNQAQQAV 1302
Cdd:COG1020  1211 LLLLLLLLLLLLLLAAAAAALLALALLLALLALAAllalaalaalAAALLALALALLALALLLLALALLLPALARARAAR 1290

                        1210      1220      1230
                  ....*....|....*....|....*....|....*...
gi 490930577 1303 QETSYRLSAELGAKLQHKLRQQGITLNVFMQMIWAMTL 1340
Cdd:COG1020  1291 TARALALLLLLALLLLLALALALLLLLLLLLALLLLAL 1328

A_NRPS_AB3403-like

cd17646

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...

1537-2031

0e+00

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 620.45 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1537 LLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQH 1616
Cdd:cd17646     3 LVAEQAARTPDAPAVVDEGRTLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDPGY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1617 PTERIKFMLQDAKSKLVIGEQKDLAAIVHPSIATFAFNELFDETKVDLssyKTTVITPQHPAYLIYTSGTTGQPKGVMVS 1696
Cdd:cd17646    83 PADRLAYMLADAGPAVVLTTADLAARLPAGGDVALLGDEALAAPPATP---PLVPPRPDNLAYVIYTSGSTGRPKGVMVT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1697 HQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSM 1776
Cdd:cd17646   160 HAGIVNRLLWMQDEYPLGPGDRVLQKTPLSFDVSVWELFWPLVAGARLVVARPGGHRDPAYLAALIREHGVTTCHFVPSM 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1777 LAVFENAATeilsSAQRQSLPicRVFCSGEALPTALAKSFTEHFSCELHNLYGPTEAAVDVSYMDATlGLHPEEScVAIG 1856
Cdd:cd17646   240 LRVFLAEPA----AGSCASLR--RVFCSGEALPPELAARFLALPGAELHNLYGPTEAAIDVTHWPVR-GPAETPS-VPIG 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1857 YPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADGSIQYIGRA 1936
Cdd:cd17646   312 RPVPNTRLYVLDDALRPVPVGVPGELYLGGVQLARGYLGRPALTAERFVPDPFGPGSRMYRTGDLARWRPDGALEFLGRS 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1937 DDQLKIRGQRIELGEIEQQLR---LISGLDVVVHaissEQNKANVQLVAYLQ---TTAPVDIDQLKKQLAKHLPAYMVPT 2010
Cdd:cd17646   392 DDQVKIRGFRVEPGEIEAALAahpAVTHAVVVAR----AAPAGAARLVGYVVpaaGAAGPDTAALRAHLAERLPEYMVPA 467

                         490       500
                  ....*....|....*....|.
gi 490930577 2011 HYMLVEQFPLSHNGKLDRKAL 2031
Cdd:cd17646   468 AFVVLDALPLTANGKLDRAAL 488

A_NRPS

cd05930

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...

487-986

2.13e-158

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 497.05 E-value: 2.13e-158

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  487 PERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRM 566
Cdd:cd05930     1 PDAVAVVDGD----QSLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSYPAERL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  567 QMMCEDANPLFVLTTQalaqqlpqniqqlhldqegvqtqirkqdasdipaenrkfdfQDVAYVIFTSGSTGRPKGVMNTH 646
Cdd:cd05930    77 AYILEDSGAKLVLTDP-----------------------------------------DDLAYVIYTSGSTGKPKGVMVEH 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  647 GSLLNLILSHkptiywpvleavNERFPDRP-LRAAHTHSFSFDSSWLQVFWML-WGQELHIFDENMRRDAFGLVQEIQQR 724
Cdd:cd05930   116 RGLVNLLLWM------------QEAYPLTPgDRVLQFTSFSFDVSVWEIFGALlAGATLVVLPEEVRKDPEALADLLAEE 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  725 QIDTLDLPPSFCAQMMTNGlfvENQHHPSL--ILIGGEAAPLALWQQLNAQ-PALFAHNLYGPTEYTVD-TF---RAELK 797
Cdd:cd05930   184 GITVLHLTPSLLRLLLQEL---ELAALPSLrlVLVGGEALPPDLVRRWRELlPGARLVNLYGPTEATVDaTYyrvPPDDE 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  798 QTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQRMYRTGDLVRWNSAG 877
Cdd:cd05930   261 EDGRVPIGRPIPNTRVYVLDENLRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPNPFGPGERMYRTGDLVRWLPDG 340

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  878 KLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSH-RLLGYCVVKDieldekTSEQLSQQYLSQLRQ 956
Cdd:cd05930   341 NLEFLGRIDDQVKIRGYRIELGEIEAALLAHPGVREAAVVAREDGDGEkRLVAYVVPDE------GGELDEEELRAHLAE 414

                         490       500       510
                  ....*....|....*....|....*....|
gi 490930577  957 NLPEYMVPSALTVMSEFPRNVSGKVDKKAL 986
Cdd:cd05930   415 RLPDYMVPSAFVVLDALPLTPNGKVDRKAL 444

NRPS_MxcG

NF038078

myxochelin non-ribosomal peptide synthetase MxcG;

15-1079

4.50e-155

myxochelin non-ribosomal peptide synthetase MxcG;

Pssm-ID: 468336 [Multi-domain] Cd Length: 1444 Bit Score: 521.59 E-value: 4.50e-155

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   15 QPARFELASTQLGIFLADHLSSIEDLYTIAHCLELPKTVDIPTFKKAIQIGLNEADTVIASYSSDPSQPFIELNNQVQFQ 94
Cdd:NF038078    1 QEARWPLSAAQHGIWLGQQLDLASPVYNAGECIEIRGPVDPAVFEAALRQAVGEAEALHMRFVPGEEGPRQLLDPSADWP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   95 IEEFDFCHLT-PKKAQQrlwDWMPSDrqCAKSLKAGETQLFRQVLFTTH-DKVYWYQRYHHIMLDGFSMINLTKRIVELY 172
Cdd:NF038078   81 LHRVDVSGTPdPWAAAQ---AWMRED--LARTVDLSRGPLFAEALFKAApDRFFWYQRAHHIALDGFGFSLLARRVAELY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  173 QQLQEGKDlSVSPFIGVNEVISERQAYENSHQFKIDQAFWKAYCEDLPSPISLSThhlAAKTTATFVKHQLRFSTGILEQ 252
Cdd:NF038078  156 TARVTGRP-ATGGFGSLRAVLDEDAAYRAGPQCELDRAFWMERFADRPTPVSLAE---PAPMSRSFVRQTRHLSPSEMER 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  253 IQALAAQTKLALNDMMMSLSLHYIYKMTDKAELVNGIPFMRRLGSKAIRSTLPTVNVLPVKFKVAEKDSWVSLAQHVQEQ 332
Cdd:NF038078  232 LQAVARQAGLSWPDLVLAATAAWLHRRTGAPEVVLGLPVMGRLGSAALRVPCMAMNIVPLRVPVRPGAGLLALARGVAAE 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  333 LREIRPHQKYDAEQILRDLNSIDIHERMYGPILNYKAFDQDLVIDGEKVKTHHISTGPIDDFEFSFIVQD--HELIIELR 410
Cdd:NF038078  312 LRAIRPHLRYRYEQLRRDLKLVGGQRRLFGPVVNIMPFDYALRFAGMPAIAHNISAGPVEDLSIGVYARSdgRGPRVDFD 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  411 ADSQRYTQDELFNHGQRLTLLLEQALIRPEQPCSNFNITTP-------QELTALTQSGIGPRVSHPeqynnVLDIFYEQV 483
Cdd:NF038078  392 ANPACYSADELDAHQREFLQLLEALLAAPEQAVARALIPGAaapapaaSRPGSLLDGGPLPAPARP-----VLELIAERA 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  484 KKYPERTAIVSGERpnlqHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPI 563
Cdd:NF038078  467 REQPDAIAVEHGPR----RMTYRELLLAARALAARLVAAGARPDTLVAVMLPRSIDAIVASLGVLFSGAGYLPLDPFGPS 542

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  564 DRMQMMCEDANPLFVLTTQALA---QQLPQNIQQLHLDQEGVQTQIRKQDASDIPAENRkfdfqdVAYVIFTSGSTGRPK 640
Cdd:NF038078  543 SRTAAILADAAPALIVTSSEHAptaKAGPQAPGALVVRRLEEAVPSPAPEAPPRPADER------LAYVIYTSGSTGQPN 616

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  641 GVMNTHGSLLNLILShkPTIYWPVleavneRFPDRPLRAAHTHsfsFDSSWLQVFWMLW-GQELHIFDENMRRDAFGLVQ 719
Cdd:NF038078  617 GVQISRGALAHFVAG--ATQRYGV------RRDDRVLQFAPLH---FDASVEEIFLTLCaGARLVLRTDEMLQSVPRLLD 685

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  720 EIQQRQIDTLDLPPSF---CAQMMTNGLFVenqhHPS---LILIGGEAA-P--LALWQQlNAQPALFAHNLYGPTEYTVD 790
Cdd:NF038078  686 ACAEHGITVLDLPTAFwheLAYSVSTGAAR----LPSslrTVIIGGEAAlPerVARWRA-AVGPRVRLLNTYGPTEATVV 760

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  791 TFRAELKQTARPV-------IGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVA-NPFEHGQ 862
Cdd:NF038078  761 ATVATLSGGGAAGdegdevpIGRPLPGVRAALLDAQGRLVAPGAEGELYLLGGGLARGYLGRPELDAARFTTlEALPGRP 840

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  863 RMYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNV-ESAVVIAEPINNSHRLLGYCVVKDIeldEK 941
Cdd:NF038078  841 RAYRTGDLVRLREDGQLVFVGRVDDEFKISGHRIDPAEVETVLLGHPGVrEAAVVGQVLPGGTRRLCAHVVADAP---AP 917

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  942 TSEQLSQqylsQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALPKPQI---RAHSRMAETPEQQLLCQITASVLKLDA 1018
Cdd:NF038078  918 SAAELRR----HLLSALPAPMVPGAFVFAERLPRTSTGKIDRAALRRAGPaeeSATSAAAATALERVVLRVWEQVLGVSG 993

                        1050      1060      1070      1080      1090      1100
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490930577 1019 IGIDDDFFMTGGDSISAIMLCTQLR-QRGYSLRPSDVFQFKTVAAMAPQLtrldEQQAAVSK 1079
Cdd:NF038078  994 LSAQDDFFELGGQSLQSIQVANRLGvALGREVPVATVFRHPTAAGLAQAL----EHGASVAA 1051

AA-adenyl-dom

amino acid adenylation domain; This model represents a domain responsible for the specific ...

1569-1966

1.63e-138

amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.

Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 439.39 E-value: 1.63e-138

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1569 ALAQQLQ-RAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFMLQDAKSKLVIGEQK--DLAAIVH 1645
Cdd:TIGR01733   11 RLARHLRaAGGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDSAlaSRLAGLV 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1646 PSIATFAFNELFDETKVDLSSYKTTVITPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRILWMQSEYPLSATDTILQKTPC 1725
Cdd:TIGR01733   91 LPVILLDPLELAALDDAPAPPPPDAPSGPDDLAYVIYTSGSTGRPKGVVVTHRSLVNLLAWLARRYGLDPDDRVLQFASL 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1726 TFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLS-LIQKYQVTTLHFVPSMLAVfenaateiLSSAQRQSLPICR-VFC 1803
Cdd:TIGR01733  171 SFDASVEEIFGALLAGATLVVPPEDEERDDAALLAaLIAEHPVTVLNLTPSLLAL--------LAAALPPALASLRlVIL 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1804 SGEALPTALAKSFTEHF-SCELHNLYGPTEAAVDVSYMDATLGLHPEESCVAIGYPVWNTQLYILDQYLRPVPVGVDGEL 1882
Cdd:TIGR01733  243 GGEALTPALVDRWRARGpGARLINLYGPTETTVWSTATLVDPDDAPRESPVPIGRPLANTRLYVLDDDLRPVPVGVVGEL 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1883 YLAGHQLAMGYLHRADLTASRFVANPF--TAGQRMYRTGDIARWHADGSIQYIGRADDQLKIRGQRIELGEIEQQLRLIS 1960
Cdd:TIGR01733  323 YIGGPGVARGYLNRPELTAERFVPDPFagGDGARLYRTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLRHP 402


                   ....*.
gi 490930577  1961 GLDVVV 1966
Cdd:TIGR01733  403 GVREAV 408

AA-adenyl-dom

amino acid adenylation domain; This model represents a domain responsible for the specific ...

504-916

8.48e-115

Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 371.21 E-value: 8.48e-115

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   504 SFAELAVKVNQLTRFLQEN-GARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRMQMMCEDANPLFVLTTQ 582
Cdd:TIGR01733    1 TYRELDERANRLARHLRAAgGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   583 ALAQQLPQnIQQLHLDQEGVQTQIRkQDASDIPAENRKFDFQDVAYVIFTSGSTGRPKGVMNTHGSLLNLILSHkptiyw 662
Cdd:TIGR01733   81 ALASRLAG-LVLPVILLDPLELAAL-DDAPAPPPPDAPSGPDDLAYVIYTSGSTGRPKGVVVTHRSLVNLLAWL------ 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   663 pvleavNERFPDRPL-RAAHTHSFSFDSSWLQVFWMLW-GQELHIFDENMRRDAFGLVQE-IQQRQIDTLDLPPSFcAQM 739
Cdd:TIGR01733  153 ------ARRYGLDPDdRVLQFASLSFDASVEEIFGALLaGATLVVPPEDEERDDAALLAAlIAEHPVTVLNLTPSL-LAL 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   740 MTNGLfVENQHHPSLILIGGEAAPLALWQQLNAQ-PALFAHNLYGPTEYTVDTF-----RAELKQTARPVIGNPIGNTQA 813
Cdd:TIGR01733  226 LAAAL-PPALASLRLVILGGEALTPALVDRWRARgPGARLINLYGPTETTVWSTatlvdPDDAPRESPVPIGRPLANTRL 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   814 YVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPF--EHGQRMYRTGDLVRWNSAGKLEFMGRCDDQIKI 891
Cdd:TIGR01733  305 YVLDDDLRPVPVGVVGELYIGGPGVARGYLNRPELTAERFVPDPFagGDGARLYRTGDLVRYLPDGNLEFLGRIDDQVKI 384

                          410       420
                   ....*....|....*....|....*
gi 490930577   892 RGYRVEIGEVENALSILTNVESAVV 916
Cdd:TIGR01733  385 RGYRIELGEIEAALLRHPGVREAVV 409

AMP-binding

AMP-binding enzyme;

1538-1943

1.47e-111

AMP-binding enzyme;

Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 362.40 E-value: 1.47e-111

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1538 LREQARITPEQTALS-DENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQH 1616
Cdd:pfam00501    1 LERQAARTPDKTALEvGEGRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1617 PTERIKFMLQDAKSKLVIGEQKDLAAIVHP--------------SIATFAFNELFDETKVDLSSYKTTVITPQ--HPAYL 1680
Cdd:pfam00501   81 PAEELAYILEDSGAKVLITDDALKLEELLEalgklevvklvlvlDRDPVLKEEPLPEEAKPADVPPPPPPPPDpdDLAYI 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1681 IYTSGTTGQPKGVMVSHQAIVNRILWMQSEYP----LSATDTILQKTPCTFDVSV-WEFFWSYLVGARLVIAPIDAHRDP 1755
Cdd:pfam00501  161 IYTSGTTGKPKGVMLTHRNLVANVLSIKRVRPrgfgLGPDDRVLSTLPLFHDFGLsLGLLGPLLAGATVVLPPGFPALDP 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1756 LALLSLIQKYQVTTLHFVPSMLAVFENAATeiLSSAQRQSLPIcrVFCSGEALPTALAKSFTEHFSCELHNLYGPTEAAV 1835
Cdd:pfam00501  241 AALLELIERYKVTVLYGVPTLLNMLLEAGA--PKRALLSSLRL--VLSGGAPLPPELARRFRELFGGALVNGYGLTETTG 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1836 DVSYMDatLGLHPEESCVAIGYPVWNTQLYILDQY-LRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVAnpftagQR 1914
Cdd:pfam00501  317 VVTTPL--PLDEDLRSLGSVGRPLPGTEVKIVDDEtGEPVPPGEPGELCVRGPGVMKGYLNDPELTAEAFDE------DG 388

                          410       420
                   ....*....|....*....|....*....
gi 490930577  1915 MYRTGDIARWHADGSIQYIGRADDQLKIR 1943
Cdd:pfam00501  389 WYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417

AMP-binding

AMP-binding enzyme;

479-892

5.65e-86

AMP-binding enzyme;

Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 288.44 E-value: 5.65e-86

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   479 FYEQVKKYPERTAIVSGERpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLD 558
Cdd:pfam00501    1 LERQAARTPDKTALEVGEG---RRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLN 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   559 LDYPIDRMQMMCEDANPLFVLTTQAL--------AQQLPQNIQQLHLDQEGVQT----QIRKQDASDIPAENRKFDFQDV 626
Cdd:pfam00501   78 PRLPAEELAYILEDSGAKVLITDDALkleelleaLGKLEVVKLVLVLDRDPVLKeeplPEEAKPADVPPPPPPPPDPDDL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   627 AYVIFTSGSTGRPKGVMNTHGSLLNLILSHKptIYWPVLEAVNERfpdrpLRAAHTHSFSFDSSWLQVFW--MLWGQELH 704
Cdd:pfam00501  158 AYIIYTSGTTGKPKGVMLTHRNLVANVLSIK--RVRPRGFGLGPD-----DRVLSTLPLFHDFGLSLGLLgpLLAGATVV 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   705 IFDENMRRDAFGLVQEIQQRQIDTLDLPPSFcAQMMTNGLFVENQHHPSL--ILIGGEAAPLALWQQLNAQPALFAHNLY 782
Cdd:pfam00501  231 LPPGFPALDPAALLELIERYKVTVLYGVPTL-LNMLLEAGAPKRALLSSLrlVLSGGAPLPPELARRFRELFGGALVNGY 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   783 GPTEYTVDT---FRAELKQTARPVIGNPIGNTQAYVLD-RHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVAnpf 858
Cdd:pfam00501  310 GLTETTGVVttpLPLDEDLRSLGSVGRPLPGTEVKIVDdETGEPVPPGEPGELCVRGPGVMKGYLNDPELTAEAFDE--- 386

                          410       420       430
                   ....*....|....*....|....*....|....
gi 490930577   859 ehgQRMYRTGDLVRWNSAGKLEFMGRCDDQIKIR 892
Cdd:pfam00501  387 ---DGWYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417

PKS_TE

smart00824

Thioesterase; Peptide synthetases are involved in the non-ribosomal synthesis of peptide ...

2148-2265

4.86e-10

Thioesterase; Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates. There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.

Pssm-ID: 214835 [Multi-domain] Cd Length: 212 Bit Score: 61.47 E-value: 4.86e-10

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   2148 FYPGSGsAWQYTVLNRYLHSDLPIIGLQSP--RPDGLLAnsTDMDELVEKQLEIMRKQQPTGPYTLLGYSLGGTVAYAVA 2225
Cdd:smart00824    6 TAAPSG-PHEYARLAAALRGRRDVSALPLPgfGPGEPLP--ASADALVEAQAEAVLRAAGGRPFVLVGHSSGGLLAHAVA 82

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 490930577   2226 AKLTEQGEKVDYLGLLDTYPAE---IHQWLDLSVEEMNAEAEQ 2265
Cdd:smart00824   83 ARLEARGIPPAAVVLLDTYPPGdpaPEGWLPELLRGVFEREDS 125

Name

Accession

Description

Interval

E-value

entF

PRK10252

enterobactin non-ribosomal peptide synthetase EntF;

1098-2372

0e+00

enterobactin non-ribosomal peptide synthetase EntF;

Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 1046.17 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1098 STILPLLPLQKGMLFLSQVENQSN-YNAFTRLSLNGDIDPVRLQQALITVLKRHPQLGGHFDSELAEEPVFIYSLHPTQA 1176
Cdd:PRK10252    5 SQHLPLVAAQPGIWMAEKLSPLPSaWSVAHYVELTGELDAPLLARAVVAGLAEADTLRMRFTEDNGEVWQWVDPALTFPL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1177 WPVQFCSVTPDLLEQT---IQEALQQPIHLDQPYGLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDF--IKAYQQ 1251
Cdd:PRK10252   85 PEIIDLRTQPDPHAAAqalMQADLQQDLRVDSGKPLVFHQLIQLGDNRWYWYQRYHHLLVDGFSFPAITRRIaaIYCAWL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1252 TNQQLPVLEHSYETVIKALSGRDHETSKviWQRD-------LADLQPLILFNQAQQAVQETSYR-----LSAELGAKLQH 1319
Cdd:PRK10252  165 RGEPTPASPFTPFADVVEEYQRYRASEA--WQRDaafwaeqRRQLPPPASLSPAPLPGRSASADilrlkLEFTDGAFRQL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1320 KLRQQGITLNVFMQMIWAMTLNIYAHREDIVFGTPVSGR--SAPIngleQQIGLFLNTIPVRVKLNMQQTLWE------- 1390
Cdd:PRK10252  243 AAQASGVQRPDLALALVALWLGRLCGRMDYAAGFIFMRRlgSAAL----TATGPVLNVLPLRVHIAAQETLPElatrlaa 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1391 QLPQL---QQLHVEHLEHDgLGLSAIQQliaqgNLFDSLLVVE------NYPDNQYLQQKLGDAAISKLTnrgyshypLA 1461
Cdd:PRK10252  319 QLKKMrrhQRYDAEQIVRD-SGRAAGDE-----PLFGPVLNIKvfdyqlDFPGVQAQTHTLATGPVNDLE--------LA 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1462 LLVIPDHQIELLLE---QRGVIDQPEHFLERMIQLIEIALNEPETSLSHYRLQLAEEHDLIQKTNQTQYYVRQSTLQQLL 1538
Cdd:PRK10252  385 LFPDEHGGLSIEILanpQRYDEATLIAHAERLKALIAQFAADPALLCGDVDILLPGEYAQLAQVNATAVEIPETTLSALV 464

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1539 REQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPT 1618
Cdd:PRK10252  465 AQQAAKTPDAPALADARYQFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTGYPD 544

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1619 ERIKFMLQDAKSKLVIGEQKDLAAIVH-PSIATFAFNELF---DETKVDLSSykttvitPQHPAYLIYTSGTTGQPKGVM 1694
Cdd:PRK10252  545 DRLKMMLEDARPSLLITTADQLPRFADvPDLTSLCYNAPLapqGAAPLQLSQ-------PHHTAYIIFTSGSTGRPKGVM 617

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1695 VSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVP 1774
Cdd:PRK10252  618 VGQTAIVNRLLWMQNHYPLTADDVVLQKTPCSFDVSVWEFFWPFIAGAKLVMAEPEAHRDPLAMQQFFAEYGVTTTHFVP 697

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1775 SMLAVFENAATEilSSAQRQSLPICRVFCSGEALPTALAKSFTEHFSCELHNLYGPTEAAVDVSYMDATlglhPEE---- 1850
Cdd:PRK10252  698 SMLAAFVASLTP--EGARQSCASLRQVFCSGEALPADLCREWQQLTGAPLHNLYGPTEAAVDVSWYPAF----GEElaav 771

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1851 --SCVAIGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADG 1928
Cdd:PRK10252  772 rgSSVPIGYPVWNTGLRILDARMRPVPPGVAGDLYLTGIQLAQGYLGRPDLTASRFIADPFAPGERMYRTGDVARWLDDG 851

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1929 SIQYIGRADDQLKIRGQRIELGEIEQQLRLISGLD-VVVHAISSEQNKANV----QLVAYL--QTTAPVDIDQLKKQLAK 2001
Cdd:PRK10252  852 AVEYLGRSDDQLKIRGQRIELGEIDRAMQALPDVEqAVTHACVINQAAATGgdarQLVGYLvsQSGLPLDTSALQAQLRE 931

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2002 HLPAYMVPTHYMLVEQFPLSHNGKLDRKALPQPHLTpSNTEKQYATSAFEHELTRIFQQILNTDQNiGVNEDFFAIGGHS 2081
Cdd:PRK10252  932 RLPPHMVPVVLLQLDQLPLSANGKLDRKALPLPELK-AQVPGRAPKTGTETIIAAAFSSLLGCDVV-DADADFFALGGHS 1009

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2082 ILVMKLAIEIRKVFKRTIPIGQLMSHVTIQRLAALLLTQErlAEVEQTGMQPILPIRSGSGHPLFCFYPGSGSAWQYTVL 2161
Cdd:PRK10252 1010 LLAMKLAAQLSRQFARQVTPGQVMVASTVAKLATLLDAEE--DESRRLGFGTILPLREGDGPTLFCFHPASGFAWQFSVL 1087

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2162 NRYLHSDLPIIGLQSPRPDGLLANSTDMDELVEKQLEIMRKQQPTGPYTLLGYSLGGTVAYAVAAKLTEQGEKVDYLGLL 2241
Cdd:PRK10252 1088 SRYLDPQWSIYGIQSPRPDGPMQTATSLDEVCEAHLATLLEQQPHGPYHLLGYSLGGTLAQGIAARLRARGEEVAFLGLL 1167

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2242 DTYPAEIHQWLDLSVEEMN----AEAEQEQLQFfndiLADADSALSEEtrrLQEDIFANYRDAVRLLKPYKMPHFDGELH 2317
Cdd:PRK10252 1168 DTWPPETQNWREKEANGLDpevlAEIDREREAF----LAAQQGSLSTE---LFTTIEGNYADAVRLLTTAHSVPFDGKAT 1240

                        1290      1300      1310      1320      1330
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 490930577 2318 LVVAEKDLLPYIQPEQQWSPLVKKLNIVRLSEAdHTDILSPQQLETLGPILNRMI 2372
Cdd:PRK10252 1241 LFVAERTLQEGMSPEQAWSPWIAELDVYRQDCA-HVDIISPEAFEKIGPILRATL 1294

PRK12467

peptide synthase; Provisional

152-2138

0e+00

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 1010.46 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  152 HHIMLDGFSMINLTKRIVELYQQLQEGKDLSVS--PFIGVNEVISER---QAYENSHQFkidqAFWKAYCEDLPSPISLS 226
Cdd:PRK12467  182 HHIISDGWSMRVLVEELVQLYSAYSQGREPSLPalPIQYADYAIWQRswlEAGERERQL----AYWQEQLGGEHTVLELP 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  227 THH-LAAKTTATFVKHQLRFSTGILEQIQALAAQTKLALNdMMMSLSLH-YIYKMTDKAELVNGIPFMRRLGSKAIRSTL 304
Cdd:PRK12467  258 TDRpRPAVPSYRGARLRVDLPQALSAGLKALAQREGVTLF-MVLLASFQtLLHRYSGQSDIRIGVPNANRNRVETERLIG 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  305 PTVNVLPVKFKVAEKDSWVSLAQHVQEQLREIRPHQKYDAEQILRDLNSidihER--MYGPILNYKAFDQDLVIDGEKVK 382
Cdd:PRK12467  337 FFVNTQVLKAEVDPQASFLELLQQVKRTALGAQAHQDLPFEQLVEALQP----ERslSHSPLFQVMFNHQNTATGGRDRE 412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  383 THHISTGPIDDFE-------FSFIVQDHELIIELRAdSQRYTQDeLFNHG--QRLTL----LLEQALIRPeqpcsnfnit 449
Cdd:PRK12467  413 GAQLPGLTVEELSwarhtaqFDLALDTYESAQGLWA-AFTYATD-LFEATtiERLAThwrnLLEAIVAEP---------- 480

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  450 tPQELTALTQSGIGPRVSHPEQYN---------NVLDIFYEQVKKYPERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQ 520
Cdd:PRK12467  481 -RRRLGELPLLDAEERARELVRWNapateyapdCVHQLIEAQARQHPERPALVFGE----QVLSYAELNRQANRLAHVLI 555

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  521 ENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRMQMMCEDANPLFVLTTQALAQQL--PQNIQQLHLD 598
Cdd:PRK12467  556 AAGVGPDVLVGIAVERSIEMVVGLLAVLKAGGAYVPLDPEYPQDRLAYMLDDSGVRLLLTQSHLLAQLpvPAGLRSLCLD 635

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  599 QEGVQTQIRKQDASDIPaenrkFDFQDVAYVIFTSGSTGRPKGVMNTHGSLLNLILShkpTIYWPVLEAVNerfpdrplR 678
Cdd:PRK12467  636 EPADLLCGYSGHNPEVA-----LDPDNLAYVIYTSGSTGQPKGVAISHGALANYVCV---IAERLQLAADD--------S 699

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  679 AAHTHSFSFDSSWLQVFWMLW-GQELHIFDENMRRDAFGLVQEIQQRQIDTLDLPPSFCAQMMTNGLFVENQHHPSLIlI 757
Cdd:PRK12467  700 MLMVSTFAFDLGVTELFGALAsGATLHLLPPDCARDAEAFAALMADQGVTVLKIVPSHLQALLQASRVALPRPQRALV-C 778

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  758 GGEAAPLAL---WQQLNAQPALFahNLYGPTEYTVDTFRAELKQTARPV----IGNPIGNTQAYVLDRHLQRCPTGVIGE 830
Cdd:PRK12467  779 GGEALQVDLlarVRALGPGARLI--NHYGPTETTVGVSTYELSDEERDFgnvpIGQPLANLGLYILDHYLNPVPVGVVGE 856

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  831 LYISGFGIANGYLGRADLSAARFVANPF-EHGQRMYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILT 909
Cdd:PRK12467  857 LYIGGAGLARGYHRRPALTAERFVPDPFgADGGRLYRTGDLARYRADGVIEYLGRMDHQVKIRGFRIELGEIEARLLAQP 936

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  910 NVESAVVIAEPINNSHRLLGYCvVKDIELDEKTSEQLSQQYLSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALPKP 989
Cdd:PRK12467  937 GVREAVVLAQPGDAGLQLVAYL-VPAAVADGAEHQATRDELKAQLRQVLPDYMVPAHLLLLDSLPLTPNGKLDRKALPKP 1015

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  990 ---QIRAHSRMAETPEQQLLCQITASVLKLDAIGIDDDFFMTGGDSISAIMLCTQLRQR-GYSLRPSDVFQFKTVAAMAp 1065
Cdd:PRK12467 1016 dasAVQATFVAPQTELEKRLAAIWADVLKVERVGLTDNFFELGGHSLLATQVISRVRQRlGIQVPLRTLFEHQTLAGFA- 1094

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1066 qlTRLDEQQAAVSKPLFSADLEQKvqekygknstiLPLLPLQKGMLFLSQVENQSN-YNAFTRLSLNGDIDPVRLQQALI 1144
Cdd:PRK12467 1095 --QAVAAQQQGAQPALPDVDRDQP-----------LPLSYAQERQWFLWQLEPGSAaYHIPQALRLKGPLDIEALERSFD 1161

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1145 TVLKRHPQLGGHFDSElAEEPVFIysLHPtqAWPVQFCSVTPDL-------LEQTIQEALQQPIHLDQ-PygLIRATLIQ 1216
Cdd:PRK12467 1162 ALVARHESLRTTFVQE-DGRTRQV--IHP--VGSLTLEEPLLLAadkdeaqLKVYVEAEARQPFDLEQgP--LLRVGLLR 1234

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1217 HAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAY----QQTNQQLPVLEHSYETVI----KALSGRDHETSKVIWQRDLAD 1288
Cdd:PRK12467 1235 LAADEHVLVLTLHHIVSDGWSMQVLVDELVALYaaysQGQSLQLPALPIQYADYAvwqrQWMDAGERARQLAYWKAQLGG 1314

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1289 LQPLIL--FNQAQQAVQetSYR-------LSAELGAKLQHKLRQQGITLnvFMQMI--WAMTLNIYAHREDIVFGTPVSG 1357
Cdd:PRK12467 1315 EQPVLElpTDRPRPAVQ--SHRgarlafeLPPALAEGLRALARREGVTL--FMLLLasFQTLLHRYSGQDDIRVGVPIAN 1390

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1358 RS-APINGLeqqIGLFLNTIPVRVKLNMQQTLWEQLPQLQQLHVEHLEHDGLglsAIQQLI---------AQGNLFDSLL 1427
Cdd:PRK12467 1391 RNrAETEGL---IGFFVNTQVLRAEVDGQASFQQLLQQVKQAALEAQAHQDL---PFEQLVealqperslSHSPLFQVMF 1464

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1428 vvenypdNQYLQQKLGDAAISKLTNRGYS------HYPLALLVIPDHQiELLLEQRGVIDQPEH-FLERM----IQLIEI 1496
Cdd:PRK12467 1465 -------NHQRDDHQAQAQLPGLSVESLSwesqtaQFDLTLDTYESSE-GLQASLTYATDLFEAsTIERLaghwLNLLQG 1536

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1497 ALNEPETSLSHYRL-QLAEEHDLIQKTNQT-QYYVRQSTLQQLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQL 1574
Cdd:PRK12467 1537 LVADPERRLGELDLlDEAERRQILEGWNAThTGYPLARLVHQLIEDQAAATPEAVALVFGEQELTYGELNRRANRLAHRL 1616

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1575 QRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFMLQDAKSKLVIGEQKDLAAIvhPSIATFAFN 1654
Cdd:PRK12467 1617 IALGVGPEVLVGIAVERSLEMVVGLLAILKAGGAYVPLDPEYPRERLAYMIEDSGIELLLTQSHLQARL--PLPDGLRSL 1694

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1655 ELfDETKVDLSSYKTT----VITPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVS 1730
Cdd:PRK12467 1695 VL-DQEDDWLEGYSDSnpavNLAPQNLAYVIYTSGSTGRPKGAGNRHGALVNRLCATQEAYQLSAADVVLQFTSFAFDVS 1773

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1731 VWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSMLAVFENAATEIlssaqRQSLPICRVFCSGEALPT 1810
Cdd:PRK12467 1774 VWELFWPLINGARLVIAPPGAHRDPEQLIQLIERQQVTTLHFVPSMLQQLLQMDEQV-----EHPLSLRRVVCGGEALEV 1848

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1811 ALAKSFTEHF-SCELHNLYGPTEAAVDVSYMDATLGLHPEESCVAIGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQL 1889
Cdd:PRK12467 1849 EALRPWLERLpDTGLFNLYGPTETAVDVTHWTCRRKDLEGRDSVPIGQPIANLSTYILDASLNPVPIGVAGELYLGGVGL 1928

                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1890 AMGYLHRADLTASRFVANPF-TAGQRMYRTGDIARWHADGSIQYIGRADDQLKIRGQRIELGEIEQQLRLISGL-DVVVH 1967
Cdd:PRK12467 1929 ARGYLNRPALTAERFVADPFgTVGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIEARLREQGGVrEAVVI 2008

                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1968 AISSEQNKanvQLVAYLQTTAP--VDID--------QLKKQLAKHLPAYMVPTHYMLVEQFPLSHNGKLDRKALPQPHlt 2037
Cdd:PRK12467 2009 AQDGANGK---QLVAYVVPTDPglVDDDeaqvalraILKNHLKASLPEYMVPAHLVFLARMPLTPNGKLDRKALPAPD-- 2083

                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2038 PSNTEKQYA--TSAFEHELTRIFQQILNTDQnIGVNEDFFAIGGHSILVMKLAIEIRKVFKRTIPiGQLMSHVTIQRLAA 2115
Cdd:PRK12467 2084 ASELQQAYVapQSELEQRLAAIWQDVLGLEQ-VGLHDNFFELGGDSIISIQVVSRARQAGIRFTP-KDLFQHQTVQSLAA 2161

                        2090      2100
                  ....*....|....*....|....*.
gi 490930577 2116 LLLTQERLAEVEQ---TGMQPILPIR 2138
Cdd:PRK12467 2162 VAQEGDGTVSIDQgpvTGDLPLLPIQ 2187

PRK12316

peptide synthase; Provisional

53-2138

0e+00

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 912.03 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   53 VDIPTFKKAIQIGLNEADTVIASY--SSDPSQPFIELNNQVQFQIEEFDFchLTPKKAQQRLWDWMPSDRQCAKSLKAGE 130
Cdd:PRK12316 1590 LDPDRFRAAWQATVDRHEILRSGFlwQDGLEQPLQVIHKQVELPFAELDW--RGREDLGQALDALAQAERQKGFDLTRAP 1667

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  131 tqLFRQVLFTT----HDKVYwyqRYHHIMLDGFSMINLTKRIVELYQ-QLQEGKDLSVSPFIGvnevISERQAYENShqf 205
Cdd:PRK12316 1668 --LLRLVLVRTgegrHHLIY---TNHHILMDGWSNAQLLGEVLQRYAgQPVAAPGGRYRDYIA----WLQRQDAAAS--- 1735

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  206 kidQAFWKAYCEDLPSPISLSTHHLAAKTTATFVKHQLRFSTGILEQIQALAAQTKLALNDMMMSLSLHYIYKMTDKAEL 285
Cdd:PRK12316 1736 ---EAFWKEQLAALEEPTRLAQAARTEDGQVGYGDHQQLLDPAQTRALAEFARAQKVTLNTLVQAAWLLLLQRYTGQETV 1812

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  286 VNGipfmrrlGSKAIRST-LPTV--------NVLPVkfkVAEKDSWVSLA---QHVQEQLREIRPHQKYDAEQILRdlns 353
Cdd:PRK12316 1813 AFG-------ATVAGRPAeLPGIeqqiglfiNTLPV---IAAPRPDQSVAdwlQEVQALNLALREHEHTPLYDIQR---- 1878

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  354 idihermYGPILNYKAFDQDLVIDGEKVkTHHISTGPIDDFEFSFIVqDHE---------------LIIELRADSQRYTQ 418
Cdd:PRK12316 1879 -------WAGQGGEALFDSLLVFENYPV-AEALKQGAPAGLVFGRVS-NHEqtnypltlavtlgetLSLQYSYDRGHFDA 1949

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  419 DELFNHGQRLTLLLEQALIRPEQPCSNFNITTPQELTALTQSGIGPRVSHPEQYNnVLDIFYEQVKKYPERTAIVSGErp 498
Cdd:PRK12316 1950 AAIERLDRHLLHLLEQMAEDAQAALGELALLDAGERQRILADWDRTPEAYPRGPG-VHQRIAEQAARAPEAIAVVFGD-- 2026

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  499 nlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRMQMMCEDANPLFV 578
Cdd:PRK12316 2027 --QHLSYAELDSRANRLAHRLRARGVGPEVRVAIAAERSFELVVALLAVLKAGGAYVPLDPNYPAERLAYMLEDSGAALL 2104

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  579 LTTQALAQQLP--QNIQQLHLDQEGvqtqirkqDASDIPAENRKFDF--QDVAYVIFTSGSTGRPKGVMNTHGSLLNLIl 654
Cdd:PRK12316 2105 LTQRHLLERLPlpAGVARLPLDRDA--------EWADYPDTAPAVQLagENLAYVIYTSGSTGLPKGVAVSHGALVAHC- 2175

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  655 shkptiywpvlEAVNERFPDRPL-RAAHTHSFSFDSSWLQVFW-MLWGQELHIFDENMRrDAFGLVQEIQQRQIDTLDLP 732
Cdd:PRK12316 2176 -----------QAAGERYELSPAdCELQFMSFSFDGAHEQWFHpLLNGARVLIRDDELW-DPEQLYDEMERHGVTILDFP 2243

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  733 PSFCAQmmtnglFVENQHH----PSL--ILIGGEAAPLALW-QQLNAQPALFAHNLYGPTEYTVDTF-----RAELKQTA 800
Cdd:PRK12316 2244 PVYLQQ------LAEHAERdgrpPAVrvYCFGGEAVPAASLrLAWEALRPVYLFNGYGPTEAVVTPLlwkcrPQDPCGAA 2317

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  801 RPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEH-GQRMYRTGDLVRWNSAGKL 879
Cdd:PRK12316 2318 YVPIGRALGNRRAYILDADLNLLAPGMAGELYLGGEGLARGYLNRPGLTAERFVPDPFSAsGERLYRTGDLARYRADGVV 2397

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  880 EFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSHRLLGYCVVKDIeldektSEQLSQQYLSQLRQNLP 959
Cdd:PRK12316 2398 EYLGRIDHQVKIRGFRIELGEIEARLQAHPAVREAVVVAQDGASGKQLVAYVVPDDA------AEDLLAELRAWLAARLP 2471

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  960 EYMVPSALTVMSEFPRNVSGKVDKKALPKPQIRAHSRMAETPE---QQLLCQITASVLKLDAIGIDDDFFMTGGDSISAI 1036
Cdd:PRK12316 2472 AYMVPAHWVVLERLPLNPNGKLDRKALPKPDVSQLRQAYVAPQeglEQRLAAIWQAVLKVEQVGLDDHFFELGGHSLLAT 2551

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1037 MLCTQLRQ-RGYSLRPSDVFQFKTVAAMApqlTRLDEQQAAVSKPLFSADLEQKvqekygknstiLPLLPLQKGMLFLSQ 1115
Cdd:PRK12316 2552 QVVSRVRQdLGLEVPLRILFERPTLAAFA---ASLESGQTSRAPVLQKVTRVQP-----------LPLSHAQQRQWFLWQ 2617

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1116 VENQS-NYNAFTRLSLNGDIDPVRLQQALITVLKRHPQLGGHFDSELAEEPVFIYSLHPTQAWPVQFCSVTPDLLEQTIQ 1194
Cdd:PRK12316 2618 LEPESaAYHLPSALHLRGVLDQAALEQAFDALVLRHETLRTRFVEVGEQTRQVILPNMSLRIVLEDCAGVADAAIRQRVA 2697

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1195 EALQQPIHLdQPYGLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYQQTNQ--QLPVLEHSYETVIKALSG 1272
Cdd:PRK12316 2698 EEIQRPFDL-ARGPLLRVRLLALDGQEHVLVITQHHIVSDGWSMQVMVDELVQAYAGARRgeQPTLPPLPLQYADYAAWQ 2776

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1273 RDHETSK------VIWQRDLADLQPLILF-------NQAQQAVQETSYRLSAELGAKLQHKLRQQGITLNVFMQMIWAMT 1339
Cdd:PRK12316 2777 RAWMDSGegarqlDYWRERLGGEQPVLELpldrprpALQSHRGARLDVALDVALSRELLALARREGVTLFMLLLASFQVL 2856

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1340 LNIYAHREDIVFGTPVSGRSAPinGLEQQIGLFLNTIPVRVKLNMQQTLWEQLPQLQQLHVEHLEHDGLGL----SAIQQ 1415
Cdd:PRK12316 2857 LHRYSGQSDIRVGVPIANRNRA--ETERLIGFFVNTQVLRAQVDAQLAFRDLLGQVKEQALGAQAHQDLPFeqlvEALQP 2934

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1416 LIAQGN--LFDSLLVVENYPDNQYLQQKLGDAAISKLTNRGYSHYPLALLVIPDHQIELLLEQRGVIDQP--EHFLERMI 1491
Cdd:PRK12316 2935 ERSLSHspLFQVMYNHQSGERAAAQLPGLHIESFAWDGAATQFDLALDTWESAEGLGASLTYATDLFDARtvERLARHWQ 3014

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1492 QLIEIALNEPETSLSHYRLQLAEEHDLI-QKTNQTQ-YYVRQSTLQQLLREQARITPEQTALSDENHQLSFSEVRLQVCA 1569
Cdd:PRK12316 3015 NLLRGMVENPQRSVDELAMLDAEERGQLlEAWNATAaEYPLERGVHRLFEEQVERTPDAVALAFGEQRLSYAELNRRANR 3094

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1570 LAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFMLQDAKSKLVIGEQkdlaaivHPSIA 1649
Cdd:PRK12316 3095 LAHRLIERGVGPDVLVGVAVERSLEMVVGLLAILKAGGAYVPLDPEYPEERLAYMLEDSGAQLLLSQS-------HLRLP 3167

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1650 TFAFNE--LFDETKVDLSSYKTTV-ITPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRILWMQSEYPLSATDTILQKTPCT 1726
Cdd:PRK12316 3168 LAQGVQvlDLDRGDENYAEANPAIrTMPENLAYVIYTSGSTGKPKGVGIRHSALSNHLCWMQQAYGLGVGDRVLQFTTFS 3247

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1727 FDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSMLAVFenaateILSSAQRQSLPICRVFCSGE 1806
Cdd:PRK12316 3248 FDVFVEELFWPLMSGARVVLAGPEDWRDPALLVELINSEGVDVLHAYPSMLQAF------LEEEDAHRCTSLKRIVCGGE 3321

                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1807 ALPTALAKSFTEHFSceLHNLYGPTEAAVDVSYMDATlglHPEESCVAIGYPVWNTQLYILDQYLRPVPVGVDGELYLAG 1886
Cdd:PRK12316 3322 ALPADLQQQVFAGLP--LYNLYGPTEATITVTHWQCV---EEGKDAVPIGRPIANRACYILDGSLEPVPVGALGELYLGG 3396

                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1887 HQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADGSIQYIGRADDQLKIRGQRIELGEIEQQLRLISGL-DVV 1965
Cdd:PRK12316 3397 EGLARGYHNRPGLTAERFVPDPFVPGERLYRTGDLARYRADGVIEYIGRVDHQVKIRGFRIELGEIEARLLEHPWVrEAV 3476

                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1966 VHAISSEqnkanvQLVAYLQTTAPVDI--DQLKKQLAKHLPAYMVPTHYMLVEQFPLSHNGKLDRKALPQPHLTPSNTEK 2043
Cdd:PRK12316 3477 VLAVDGR------QLVAYVVPEDEAGDlrEALKAHLKASLPEYMVPAHLLFLERMPLTPNGKLDRKALPRPDAALLQQDY 3550

                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2044 QYATSAFEHELTRIFQQILNTDQnIGVNEDFFAIGGHSILVMKLAIEIRKVFKRTIPiGQLMSHVTIQRLAALLLTQERL 2123
Cdd:PRK12316 3551 VAPVNELERRLAAIWADVLKLEQ-VGLTDNFFELGGDSIISLQVVSRARQAGIRFTP-KDLFQHQTIQGLARVARVGGGV 3628

                        2170
                  ....*....|....*...
gi 490930577 2124 AeVEQ---TGMQPILPIR 2138
Cdd:PRK12316 3629 A-VDQgpvSGETLLLPIQ 3645

EntF

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

1097-2338

0e+00

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 785.20 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1097 NSTILPLLPLQKGMLFLSQVENQSNYNAFTRLSLNGDIDPVRLQQALITVLKRHPQLGGHFDSELAEEPVFIYSLHPTQA 1176
Cdd:COG1020    15 AAPLPLSAAQQRLWLLLLLLLGSAAYNLALALLLLGLLLVAALLLLAALLARRRRALRTRLRTRAGRPVQVIQPVVAAPL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1177 WPVQFCSVTPDL----LEQTIQEALQQPIHLDQPyGLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYQQ- 1251
Cdd:COG1020    95 PVVVLLVDLEALaeaaAEAAAAAEALAPFDLLRG-PLLRLLLLLLLLLLLLLLLALHHIISDGLSDGLLLAELLRLYLAa 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1252 -TNQQLPVLE------HSYETVIKALSGRDHETSKVIWQRDLADLQPLILFNQAQQAVQETSYR-------LSAELGAKL 1317
Cdd:COG1020   174 yAGAPLPLPPlpiqyaDYALWQREWLQGEELARQLAYWRQQLAGLPPLLELPTDRPRPAVQSYRgarvsfrLPAELTAAL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1318 QHKLRQQGITLNVFMQMIWAMTLNIYAHREDIVFGTPVSGRSAPinGLEQQIGLFLNTIPVRVKLNMQQTLWEQLPQLQQ 1397
Cdd:COG1020   254 RALARRHGVTLFMVLLAAFALLLARYSGQDDVVVGTPVAGRPRP--ELEGLVGFFVNTLPLRVDLSGDPSFAELLARVRE 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1398 LHVEHLEHDGLGLSAIQQLI------AQGNLFDSLLVVENYPDNQylqQKLGDAAISKLT-NRGYSHYPLALLVIP-DHQ 1469
Cdd:COG1020   332 TLLAAYAHQDLPFERLVEELqperdlSRNPLFQVMFVLQNAPADE---LELPGLTLEPLElDSGTAKFDLTLTVVEtGDG 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1470 IELLLE-QRGVIDQP--EHFLERMIQLIEIALNEPETSLSHYRLQLAEEHD-LIQKTNQTQ-YYVRQSTLQQLLREQARI 1544
Cdd:COG1020   409 LRLTLEyNTDLFDAAtiERMAGHLVTLLEALAADPDQPLGDLPLLTAAERQqLLAEWNATAaPYPADATLHELFEAQAAR 488

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1545 TPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFM 1624
Cdd:COG1020   489 TPDAVAVVFGDQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGAAYVPLDPAYPAERLAYM 568

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1625 LQDAKSKLVIGEQKDLAAIVHPSIATFAFNELfdetkvDLSSYKTT----VITPQHPAYLIYTSGTTGQPKGVMVSHQAI 1700
Cdd:COG1020   569 LEDAGARLVLTQSALAARLPELGVPVLALDAL------ALAAEPATnppvPVTPDDLAYVIYTSGSTGRPKGVMVEHRAL 642

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1701 VNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSMLAVF 1780
Cdd:COG1020   643 VNLLAWMQRRYGLGPGDRVLQFASLSFDASVWEIFGALLSGATLVLAPPEARRDPAALAELLARHRVTVLNLTPSLLRAL 722

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1781 ENAATEILSSAQrqslpicRVFCSGEALPTALAKSFTEHFS-CELHNLYGPTEAAVDVSYMDATLGLHPEEScVAIGYPV 1859
Cdd:COG1020   723 LDAAPEALPSLR-------LVLVGGEALPPELVRRWRARLPgARLVNLYGPTETTVDSTYYEVTPPDADGGS-VPIGRPI 794

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1860 WNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFT-AGQRMYRTGDIARWHADGSIQYIGRADD 1938
Cdd:COG1020   795 ANTRVYVLDAHLQPVPVGVPGELYIGGAGLARGYLNRPELTAERFVADPFGfPGARLYRTGDLARWLPDGNLEFLGRADD 874

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1939 QLKIRGQRIELGEIEQQLRLISGL-DVVVHAIssEQNKANVQLVAYL--QTTAPVDIDQLKKQLAKHLPAYMVPTHYMLV 2015
Cdd:COG1020   875 QVKIRGFRIELGEIEAALLQHPGVrEAVVVAR--EDAPGDKRLVAYVvpEAGAAAAAALLRLALALLLPPYMVPAAVVLL 952

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2016 EQFPLSHNGKLDRKALPQPHLTPSNTEKQYATSAFEHELTRIFQQILNTDqnIGVNEDFFAIGGHSILVMKLAIEIRKVF 2095
Cdd:COG1020   953 LPLPLTGNGKLDRLALPAPAAAAAAAAAAPPAEEEEEEAALALLLLLVVV--VGDDDFFFFGGGLGLLLLLALARAARLL 1030

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2096 KRTIPIGQLMSHVTIQRLAALLLTQERLAEVEQTGMQPILPIRsgsghPLFCFYPGSGSAWQYTVLNRYLHSDLPIIGLQ 2175
Cdd:COG1020  1031 LLLLLLLLLFLAAAAAAAAAAAAAAAAAAAAPLAAAAAPLPLP-----PLLLSLLALLLALLLLLALLALLALLLLLLLL 1105

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2176 SPRPDGLLANSTDMDELVEKQLEIMRKQQPTGPYTLLGYSLGGTVAYAVAAKLTEQGEKVDylgLLDTYPAEIHQWLDLS 2255
Cdd:COG1020  1106 LLLLALLLLLALLLALLAALRARRAVRQEGPRLRLLVALAAALALAALLALLLAAAAAAAE---LLAAAALLLLLALLLL 1182

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2256 VEEMNAEAEQEQLQFFNDILADADSALSEETRRLQEDIFANYRDAVRLLKPYKMPHFDGELHLVVAEKDLLPYIQPEQQW 2335
Cdd:COG1020  1183 ALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLAAAAAALLALALLLALLALAALLALAALAALAAALLAL 1262


                  ...
gi 490930577 2336 SPL 2338
Cdd:COG1020  1263 ALA 1265

PRK05691

peptide synthase; Validated

152-2138

0e+00

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 773.19 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  152 HHIMLDGFSMINLTKRIVELYQQLQEGKDLSVSPF-IGVNEVISERQAYENSHQFKIDQAFWKAYCEDLPSPISLSTHH- 229
Cdd:PRK05691  808 HHIVADGWSLNILLDEFSRLYAAACQGQTAELAPLpLGYADYGAWQRQWLAQGEAARQLAYWKAQLGDEQPVLELATDHp 887

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  230 LAAKTTATFVKHQLRFSTGILEQIQALAAQTKLALNDMMMSLSLHYIYKMTDKAELVNGIPfmrrlgsKAIRSTLPT--- 306
Cdd:PRK05691  888 RSARQAHSAARYSLRVDASLSEALRGLAQAHQATLFMVLLAAFQALLHRYSGQGDIRIGVP-------NANRPRLETqgl 960

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  307 ----VNVLPVKFKVAEKDSWVSLAQHVQEQLREIRPHQKYDAEQILRDLNSidihERMYGP---ILNYKAFDQDLV---- 375
Cdd:PRK05691  961 vgffINTQVLRAQLDGRLPFTALLAQVRQATLGAQAHQDLPFEQLVEALPQ----AREQGLfqvMFNHQQRDLSALrrlp 1036

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  376 -IDGEKVKTHhistgpidDFEFSFIVQ-----DHELIIELRADsqrYTqDELFNH------GQRLTLLLEQALIRPEQPC 443
Cdd:PRK05691 1037 gLLAEELPWH--------SREAKFDLQlhseeDRNGRLTLSFD---YA-AELFDAatierlAEHFLALLEQVCEDPQRAL 1104

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  444 SNFNITTPQELTALTQSGIGP----RVSHPEQYNnvldifyEQVKKYPERTAIVSGErpnlQHLSFAELAVKVNQLTRFL 519
Cdd:PRK05691 1105 GDVQLLDAAERAQLAQWGQAPcapaQAWLPELLN-------EQARQTPERIALVWDG----GSLDYAELHAQANRLAHYL 1173

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  520 QENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRMQMMCEDANPLFVLTTQALAQQLPQ-------NI 592
Cdd:PRK05691 1174 RDKGVGPDVCVAIAAERSPQLLVGLLAILKAGGAYVPLDPDYPAERLAYMLADSGVELLLTQSHLLERLPQaegvsaiAL 1253

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  593 QQLHLDQEGVQtqirkqdasdipAENRKFDFQDVAYVIFTSGSTGRPKGVMNTHGSLLNLILSHKPTIywpvleAVNERf 672
Cdd:PRK05691 1254 DSLHLDSWPSQ------------APGLHLHGDNLAYVIYTSGSTGQPKGVGNTHAALAERLQWMQATY------ALDDS- 1314

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  673 pDRPLRAAhthSFSFDSSWLQVFW-MLWGQELHIFDENMRRDAFGLVQEIQQRQIDTLDLPPSFCaQMMTNGLFVENQHH 751
Cdd:PRK05691 1315 -DVLMQKA---PISFDVSVWECFWpLITGCRLVLAGPGEHRDPQRIAELVQQYGVTTLHFVPPLL-QLFIDEPLAAACTS 1389

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  752 PSLILIGGEAAPLALWQQLNAQ-PALFAHNLYGPTEYTVDT--FRAELKQTARPVIGNPIGNTQAYVLDRHLQRCPTGVI 828
Cdd:PRK05691 1390 LRRLFSGGEALPAELRNRVLQRlPQVQLHNRYGPTETAINVthWQCQAEDGERSPIGRPLGNVLCRVLDAELNLLPPGVA 1469

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  829 GELYISGFGIANGYLGRADLSAARFVANPF-EHGQRMYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSI 907
Cdd:PRK05691 1470 GELCIGGAGLARGYLGRPALTAERFVPDPLgEDGARLYRTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQARLLA 1549

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  908 LTNVESAVVIAEPINNSHRLLGYCVVkdieldEKTSEQLSQQYLSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALP 987
Cdd:PRK05691 1550 QPGVAQAAVLVREGAAGAQLVGYYTG------EAGQEAEAERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRALP 1623

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  988 KPQIRAHSRMA-ETPEQQLLCQITASVLKLDAIGIDDDFFMTGGDSISAIMLCTQLRQR-GYSLRPSDVFQFKTVAAMAP 1065
Cdd:PRK05691 1624 EPVWQQREHVEpRTELQQQIAAIWREVLGLPRVGLRDDFFALGGHSLLATQIVSRTRQAcDVELPLRALFEASELGAFAE 1703

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1066 QLTRLDEQQAAVSK-PLFSADLEQKVqekygknstilPLLPLQKGMLFLSQVENQS-NYNAFTRLSLNGDIDPVRLQQAL 1143
Cdd:PRK05691 1704 QVARIQAAGERNSQgAIARVDRSQPV-----------PLSYSQQRMWFLWQMEPDSpAYNVGGMARLSGVLDVDRFEAAL 1772

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1144 ITVLKRHPQLGGHFDSElaeEPVFIYSLHPTQAWPVQ---FCSVTPDLLEQTIQEALQQPIHldQPYGL-----IRATLI 1215
Cdd:PRK05691 1773 QALILRHETLRTTFPSV---DGVPVQQVAEDSGLRMDwqdFSALPADARQQRLQQLADSEAH--QPFDLergplLRACLV 1847

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1216 QHAPEQSELLIMVHHLLTDGWSTPLFLQD-------FIKAYQQTNQQLPVLEHSYETVIKA-LSGRDHETSKVIWQRDLA 1287
Cdd:PRK05691 1848 KAAEREHYFVLTLHHIVTEGWAMDIFARElgalyeaFLDDRESPLEPLPVQYLDYSVWQRQwLESGERQRQLDYWKAQLG 1927

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1288 DLQPLILF--NQAQQAVQETS---YR--LSAELGAKLQHKLRQQGITLNVFMQMIWAMTLNIYAHREDIVFGTPVSGRSA 1360
Cdd:PRK05691 1928 NEHPLLELpaDRPRPPVQSHRgelYRfdLSPELAARVRAFNAQRGLTLFMTMTATLAALLYRYSGQRDLRIGAPVANRIR 2007

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1361 PINglEQQIGLFLNTIPVRVKLNMQQTLWEQLPQLQQLHVEHLEHDGLG----LSAIQ--QLIAQGNLFDSLLVVENYPD 1434
Cdd:PRK05691 2008 PES--EGLIGAFLNTQVLRCQLDGQMSVSELLEQVRQTVIEGQSHQDLPfdhlVEALQppRSAAYNPLFQVMCNVQRWEF 2085

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1435 NQylQQKLGDAAISKLTNRGYS-HYPLALLVIP-DHQIELLLE-QRGVIDQP------EHFLermiQLIEIALNEPETSL 1505
Cdd:PRK05691 2086 QQ--SRQLAGMTVEYLVNDARAtKFDLNLEVTDlDGRLGCCLTySRDLFDEPriarmaEHWQ----NLLEALLGDPQQRL 2159

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1506 SHY-RLQLAEEHDLIQKTNQTQY-YVRQSTLQQLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGD 1583
Cdd:PRK05691 2160 AELpLLAAAEQQQLLDSLAGEAGeARLDQTLHGLFAAQAARTPQAPALTFAGQTLSYAELDARANRLARALRERGVGPQV 2239

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1584 IVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFMLQDAKSKLVIGEQKDLAAI--VHPSIATFAfnelFDETK 1661
Cdd:PRK05691 2240 RVGLALERSLEMVVGLLAILKAGGAYVPLDPEYPLERLHYMIEDSGIGLLLSDRALFEALgeLPAGVARWC----LEDDA 2315

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1662 VDLSSYKTT----VITPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWS 1737
Cdd:PRK05691 2316 AALAAYSDAplpfLSLPQHQAYLIYTSGSTGKPKGVVVSHGEIAMHCQAVIERFGMRADDCELHFYSINFDAASERLLVP 2395

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1738 YLVGARLVIAPiDAHRDPLALLSLIQKYQVTTLHFVPSmlavFENAATEILSSaQRQSLPICRVFCSGEALPTALAKSFT 1817
Cdd:PRK05691 2396 LLCGARVVLRA-QGQWGAEEICQLIREQQVSILGFTPS----YGSQLAQWLAG-QGEQLPVRMCITGGEALTGEHLQRIR 2469

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1818 EHFSCEL-HNLYGPTEAAVDVSYMDATLGLHPEESCVAIGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHR 1896
Cdd:PRK05691 2470 QAFAPQLfFNAYGPTETVVMPLACLAPEQLEEGAASVPIGRVVGARVAYILDADLALVPQGATGELYVGGAGLAQGYHDR 2549

                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1897 ADLTASRFVANPFTA-GQRMYRTGDIARWHADGSIQYIGRADDQLKIRGQRIELGEIEQQLRLISGL-DVVVHAISSEQN 1974
Cdd:PRK05691 2550 PGLTAERFVADPFAAdGGRLYRTGDLVRLRADGLVEYVGRIDHQVKIRGFRIELGEIESRLLEHPAVrEAVVLALDTPSG 2629

                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1975 KanvQLVAYLQT-TAPVDIDQ-------LKKQLAKHLPAYMVPTHYMLVEQFPLSHNGKLDRKALPQPHLTPSNTEKQYA 2046
Cdd:PRK05691 2630 K---QLAGYLVSaVAGQDDEAqaalreaLKAHLKQQLPDYMVPAHLILLDSLPLTANGKLDRRALPAPDPELNRQAYQAP 2706

                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2047 TSAFEHELTRIFQQILNTDQnIGVNEDFFAIGGHSILVMKLAIEIRKVFKRTIPiGQLMSHVTIQRLAAlLLTQERLAEV 2126
Cdd:PRK05691 2707 RSELEQQLAQIWREVLNVER-VGLGDNFFELGGDSILSIQVVSRARQLGIHFSP-RDLFQHQTVQTLAA-VATHSEAAQA 2783

                        2090
                  ....*....|....*
gi 490930577 2127 EQ---TGMQPILPIR 2138
Cdd:PRK05691 2784 EQgplQGASGLTPIQ 2798

entF

PRK10252

enterobactin non-ribosomal peptide synthetase EntF;

17-1073

0e+00

enterobactin non-ribosomal peptide synthetase EntF;

Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 727.99 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   17 ARFELASTQLGIFLADHLSSIEDLYTIAHCLELPKTVDIPTFKKAIQIGLNEADTVIASYSSDPSQPFIELNNQVQFQIE 96
Cdd:PRK10252    6 QHLPLVAAQPGIWMAEKLSPLPSAWSVAHYVELTGELDAPLLARAVVAGLAEADTLRMRFTEDNGEVWQWVDPALTFPLP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   97 EF-DFCHLTPKKAQQRlwDWMPSDRQCAKSLKAGETqLFRQVLFTTHDK-VYWYQRYHHIMLDGFSMINLTKRIVELYQQ 174
Cdd:PRK10252   86 EIiDLRTQPDPHAAAQ--ALMQADLQQDLRVDSGKP-LVFHQLIQLGDNrWYWYQRYHHLLVDGFSFPAITRRIAAIYCA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  175 LQEGKDLSVSPFIGVNEVISERQAYENSHQFKIDQAFWKAYCEDLPSPISLSTHHLAAKTTAT-FVKHQLRFSTGILEQI 253
Cdd:PRK10252  163 WLRGEPTPASPFTPFADVVEEYQRYRASEAWQRDAAFWAEQRRQLPPPASLSPAPLPGRSASAdILRLKLEFTDGAFRQL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  254 QALAAQTKLAlnDMMMSLSLHYIYKMTDKAELVNGIPFMRRLGSKAIRSTLPTVNVLPVKFKVAEKDSWVSLAQHVQEQL 333
Cdd:PRK10252  243 AAQASGVQRP--DLALALVALWLGRLCGRMDYAAGFIFMRRLGSAALTATGPVLNVLPLRVHIAAQETLPELATRLAAQL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  334 REIRPHQKYDAEQILRDLNSIDIHERMYGPILNYKAFDQDLVIDGEKVKTHHISTGPIDDFEFS-FIVQDHELIIELRAD 412
Cdd:PRK10252  321 KKMRRHQRYDAEQIVRDSGRAAGDEPLFGPVLNIKVFDYQLDFPGVQAQTHTLATGPVNDLELAlFPDEHGGLSIEILAN 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  413 SQRYTQDELFNHGQRLTLLLEQALIRPEQPCSNFNITTPQELTALTQsgiGPRVSHPEQYNNVLDIFYEQVKKYPERTAI 492
Cdd:PRK10252  401 PQRYDEATLIAHAERLKALIAQFAADPALLCGDVDILLPGEYAQLAQ---VNATAVEIPETTLSALVAQQAAKTPDAPAL 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  493 VSGErpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRMQMMCED 572
Cdd:PRK10252  478 ADAR----YQFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTGYPDDRLKMMLED 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  573 ANPLFVLTTQALAQQLPqniqqlHLDQEGVQTQIRKQDASDIPAENRKFDfQDVAYVIFTSGSTGRPKGVMNTHGSLLNL 652
Cdd:PRK10252  554 ARPSLLITTADQLPRFA------DVPDLTSLCYNAPLAPQGAAPLQLSQP-HHTAYIIFTSGSTGRPKGVMVGQTAIVNR 626

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  653 ILshkptiyWpvleaVNERFPDRPL-RAAHTHSFSFDSSWLQVFW-MLWGQELHIFDENMRRDAFGLVQEIQQRQIDTLD 730
Cdd:PRK10252  627 LL-------W-----MQNHYPLTADdVVLQKTPCSFDVSVWEFFWpFIAGAKLVMAEPEAHRDPLAMQQFFAEYGVTTTH 694

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  731 LPPSFCAQMMtNGLFVENQHHPSLIL----IGGEAAPLAL---WQQLNAQPAlfaHNLYGPTEYTVD-----TFRAELKQ 798
Cdd:PRK10252  695 FVPSMLAAFV-ASLTPEGARQSCASLrqvfCSGEALPADLcreWQQLTGAPL---HNLYGPTEAAVDvswypAFGEELAA 770

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  799 -TARPV-IGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQRMYRTGDLVRWNSA 876
Cdd:PRK10252  771 vRGSSVpIGYPVWNTGLRILDARMRPVPPGVAGDLYLTGIQLAQGYLGRPDLTASRFIADPFAPGERMYRTGDVARWLDD 850

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  877 GKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINN-------SHRLLGYCVVKDIE-LDektSEQLsq 948
Cdd:PRK10252  851 GAVEYLGRSDDQLKIRGQRIELGEIDRAMQALPDVEQAVTHACVINQaaatggdARQLVGYLVSQSGLpLD---TSAL-- 925

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  949 qyLSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALPKPQI--RAHSRMAETPEQQLLCQITASVLKLDAIGIDDDFF 1026
Cdd:PRK10252  926 --QAQLRERLPPHMVPVVLLQLDQLPLSANGKLDRKALPLPELkaQVPGRAPKTGTETIIAAAFSSLLGCDVVDADADFF 1003

                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|....*...
gi 490930577 1027 MTGGDSISAIMLCTQLRQR-GYSLRPSDVFQFKTVAAMApqlTRLDEQ 1073
Cdd:PRK10252 1004 ALGGHSLLAMKLAAQLSRQfARQVTPGQVMVASTVAKLA---TLLDAE 1048

PRK12467

peptide synthase; Provisional

1039-2245

0e+00

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 722.33 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1039 CTQLRQRGYSlrPSDvfqFKTVAAMAPQLTRLdeqqaavskPLFSADLEQkvqekygknstILPLLPLQKGMLFLSQVEN 1118
Cdd:PRK12467 2610 CCSNDQRGVT--PSD---FPLAGLSQEQLDRL---------PVAVGDIED-----------IYPLSPMQQGMLFHTLYEG 2664

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1119 QS-NYNAFTRLSLNGdIDPVRLQQALITVLKRHPQLGGHF--DSELaEEPVFIysLHPTQAWPVQFC-----SVTPDLLE 1190
Cdd:PRK12467 2665 GAgDYINQMRVDVEG-LDVERFRTAWQAVIDRHEILRSGFlwDGEL-EEPLQV--VYKQARLPFSRLdwrdrADLEQALD 2740

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1191 QTIQEALQQPIHLDQPyGLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYqqTNQQLPVLEHSYETVIKAL 1270
Cdd:PRK12467 2741 ALAAADRQQGFDLLSA-PLLRLTLVRTGEDRHHLIYTNHHILMDGWSGSQLLGEVLQRY--FGQPPPAREGRYRDYIAWL 2817

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1271 SGRDHETSKVIWQRDLADLQPLILFNQAQQ-------AVQETSYR-LSAELGAKLQHKLRQQGITLNVFMQMIWAMTLNI 1342
Cdd:PRK12467 2818 QAQDAEASEAFWKEQLAALEEPTRLARALYpapaeavAGHGAHYLhLDATQTRQLIEFARRHRVTLNTLVQGAWLLLLQR 2897

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1343 YAHREDIVFGTPVSGRSAPINGLEQQIGLFLNTIPVRVKLNMQQTLWEQLPQLQQLHVEHLEHDGLGLSAIQQLIAQGN- 1421
Cdd:PRK12467 2898 FTGQDTVCFGATVAGRPAQLRGAEQQLGLFINTLPVIASPRAEQTVSDWLQQVQAQNLALREFEHTPLADIQRWAGQGGe 2977

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1422 -LFDSLLVVENYPDNQYLQQKL-GDAAISKLTNRGYSHYPLALLVIPDHQIEL-LLEQRGVIDQP--EHFLERMIQLIEI 1496
Cdd:PRK12467 2978 aLFDSILVFENYPISEALKQGApSGLRFGAVSSREQTNYPLTLAVGLGDTLELeFSYDRQHFDAAaiERLAESFDRLLQA 3057

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1497 ALNEPETSLSHYRLQLAEEHDLI--QKTNQTQYYVRQSTLQQLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQL 1574
Cdd:PRK12467 3058 MLNNPAARLGELPTLAAHERRQVlhAWNATAAAYPSERLVHQLIEAQVARTPEAPALVFGDQQLSYAELNRRANRLAHRL 3137

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1575 QRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFMLQDAKSKLVIGEQKDLAAIVHPsiatfAFN 1654
Cdd:PRK12467 3138 IAIGVGPDVLVGVAVERSVEMIVALLAVLKAGGAYVPLDPEYPRERLAYMIEDSGVKLLLTQAHLLEQLPAP-----AGD 3212

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1655 ELFDETKVDLSSYK----TTVITPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVS 1730
Cdd:PRK12467 3213 TALTLDRLDLNGYSennpSTRVMGENLAYVIYTSGSTGKPKGVGVRHGALANHLCWIAEAYELDANDRVLLFMSFSFDGA 3292

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1731 VWEFFWSYLVGARLVIAPIDaHRDPLALLSLIQKYQVTTLHFVPSMLAVFenaateiLSSAQRQSL-PICRVFCSGEALP 1809
Cdd:PRK12467 3293 QERFLWTLICGGCLVVRDND-LWDPEELWQAIHAHRISIACFPPAYLQQF-------AEDAGGADCaSLDIYVFGGEAVP 3364

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1810 -TALAKSFTEHFSCELHNLYGPTEAAVDVSYMDATLGLHPEESCVAIGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQ 1888
Cdd:PRK12467 3365 pAAFEQVKRKLKPRGLTNGYGPTEAVVTVTLWKCGGDAVCEAPYAPIGRPVAGRSIYVLDGQLNPVPVGVAGELYIGGVG 3444

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1889 LAMGYLHRADLTASRFVANPF-TAGQRMYRTGDIARWHADGSIQYIGRADDQLKIRGQRIELGEIEQQLRLISGL-DVVV 1966
Cdd:PRK12467 3445 LARGYHQRPSLTAERFVADPFsGSGGRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIEARLLQHPSVrEAVV 3524

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1967 HAISSEQNKanvQLVAYLQTTAPVD--IDQLKKQLAKHLPAYMVPTHYMLVEQFPLSHNGKLDRKALPQPHLTPSNtEKQ 2044
Cdd:PRK12467 3525 LARDGAGGK---QLVAYVVPADPQGdwRETLRDHLAASLPDYMVPAQLLVLAAMPLGPNGKVDRKALPDPDAKGSR-EYV 3600

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2045 YATSAFEHELTRIFQQILNTDQnIGVNEDFFAIGGHSILVMKLAIEIRKVFKRTIPIGQLMSHVTIQRLAALLltqerla 2124
Cdd:PRK12467 3601 APRSEVEQQLAAIWADVLGVEQ-VGVTDNFFELGGDSLLALQVLSRIRQSLGLKLSLRDLMSAPTIAELAGYS------- 3672

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2125 EVEQTGMQPILPI--RSGSGHPLFCFYPGSGSAWQYTVLNRYLHSDLPIIGLQSPR--PDGllANSTDMDELVEKQLEIM 2200
Cdd:PRK12467 3673 PLGDVPVNLLLDLnrLETGFPALFCRHEGLGTVFDYEPLAVILEGDRHVLGLTCRHllDDG--WQDTSLQAMAVQYADYI 3750

                        1210      1220      1230      1240
                  ....*....|....*....|....*....|....*....|....*
gi 490930577 2201 RKQQPTGPYTLLGYSLGGTVAYAVAAKLTEQGEKVDYLGLLDTYP 2245
Cdd:PRK12467 3751 LWQQAKGPYGLLGWSLGGTLARLVAELLEREGESEAFLGLFDNTL 3795

EntF

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...

133-1340

0e+00

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 621.49 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  133 LFRQVLFTTHDKVYW-YQRYHHIMLDGFSMINLTKRIVELYQQLQEGKDLSVSP-FIGVNEVISERQAYENSHQFKIDQA 210
Cdd:COG1020   130 LLRLLLLLLLLLLLLlLLALHHIISDGLSDGLLLAELLRLYLAAYAGAPLPLPPlPIQYADYALWQREWLQGEELARQLA 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  211 FWKAYCEDLPSPISLSTHHL-AAKTTATFVKHQLRFSTGILEQIQALAAQTKLALNDMMMSLSLHYIYKMTDKAELVNGI 289
Cdd:COG1020   210 YWRQQLAGLPPLLELPTDRPrPAVQSYRGARVSFRLPAELTAALRALARRHGVTLFMVLLAAFALLLARYSGQDDVVVGT 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  290 PFMRRLGSkAIRSTL-PTVNVLPVKFKVAEKDSWVSLAQHVQEQLREIRPHQKYDAEQILRDLNSIDIHERM--YGPILN 366
Cdd:COG1020   290 PVAGRPRP-ELEGLVgFFVNTLPLRVDLSGDPSFAELLARVRETLLAAYAHQDLPFERLVEELQPERDLSRNplFQVMFV 368

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  367 YKAFDQD-LVIDGEKVKTHHISTG-PIDDFEFSFIVQDHELIIELRADSQRYTQDELFNHGQRLTLLLEQALIRPEQPCS 444
Cdd:COG1020   369 LQNAPADeLELPGLTLEPLELDSGtAKFDLTLTVVETGDGLRLTLEYNTDLFDAATIERMAGHLVTLLEALAADPDQPLG 448

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  445 NFNITTPQELTALTQSGIGPRVSHPEQyNNVLDIFYEQVKKYPERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGA 524
Cdd:COG1020   449 DLPLLTAAERQQLLAEWNATAAPYPAD-ATLHELFEAQAARTPDAVAVVFGD----QSLTYAELNARANRLAHHLRALGV 523

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  525 RKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRMQMMCEDANPLFVLTTQALAQQLPQ-NIQQLHLDQEgvq 603
Cdd:COG1020   524 GPGDLVGVCLERSLEMVVALLAVLKAGAAYVPLDPAYPAERLAYMLEDAGARLVLTQSALAARLPElGVPVLALDAL--- 600

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  604 tQIRKQDASDIPAENRKfdfQDVAYVIFTSGSTGRPKGVMNTHGSLLNLILSHkptiywpvleavNERFPDRP-LRAAHT 682
Cdd:COG1020   601 -ALAAEPATNPPVPVTP---DDLAYVIYTSGSTGRPKGVMVEHRALVNLLAWM------------QRRYGLGPgDRVLQF 664

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  683 HSFSFDSSWLQVFWMLW-GQELHIFDENMRRDAFGLVQEIQQRQIDTLDLPPSFCAQMMTNGLfvENQHHPSLILIGGEA 761
Cdd:COG1020   665 ASLSFDASVWEIFGALLsGATLVLAPPEARRDPAALAELLARHRVTVLNLTPSLLRALLDAAP--EALPSLRLVLVGGEA 742

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  762 APLALWQQLNAQ-PALFAHNLYGPTEYTVDT----FRAELKQTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGF 836
Cdd:COG1020   743 LPPELVRRWRARlPGARLVNLYGPTETTVDStyyeVTPPDADGGSVPIGRPIANTRVYVLDAHLQPVPVGVPGELYIGGA 822

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  837 GIANGYLGRADLSAARFVANPF-EHGQRMYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAV 915
Cdd:COG1020   823 GLARGYLNRPELTAERFVADPFgFPGARLYRTGDLARWLPDGNLEFLGRADDQVKIRGFRIELGEIEAALLQHPGVREAV 902

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  916 VIAEPINNSHRLLGYCVVkdielDEKTSEQLSQQYLSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALPKPQIRAHS 995
Cdd:COG1020   903 VVAREDAPGDKRLVAYVV-----PEAGAAAAAALLRLALALLLPPYMVPAAVVLLLPLPLTGNGKLDRLALPAPAAAAAA 977

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  996 RMAETPEQQLLCQITASVLKL---DAIGIDDDFFMTGGDSISAIMLCTQLRQRGYSLRPSDVFQFKTVAAMAPQLTRLDE 1072
Cdd:COG1020   978 AAAAPPAEEEEEEAALALLLLlvvVVGDDDFFFFGGGLGLLLLLALARAARLLLLLLLLLLLFLAAAAAAAAAAAAAAAA 1057

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1073 QQAAVSKPLFSADLEQKVQEKYGKNSTILPLLPLQKGMLFLSQVENQSNYNAFTRLSLNGDIDPVRLQQALITVLKRHPQ 1152
Cdd:COG1020  1058 AAAAPLAAAAAPLPLPPLLLSLLALLLALLLLLALLALLALLLLLLLLLLLLALLLLLALLLALLAALRARRAVRQEGPR 1137

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1153 LGGHFDSELAEEPVFIYSLHPTQAWPVQfcsvtpdLLEQTIQEALQQPIHLDQPYGLIRATLIQHAPEQSELLIMVHHLL 1232
Cdd:COG1020  1138 LRLLVALAAALALAALLALLLAAAAAAA-------ELLAAAALLLLLALLLLALLLLLLLLLLLLLLLLLLLLLLLLLLL 1210

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1233 TDGWSTPLFLQDFIKAYQQTNQQLPVLEHSYETVI----------KALSGRDHETSKVIWQRDLADLQPLILFNQAQQAV 1302
Cdd:COG1020  1211 LLLLLLLLLLLLLLAAAAAALLALALLLALLALAAllalaalaalAAALLALALALLALALLLLALALLLPALARARAAR 1290

                        1210      1220      1230
                  ....*....|....*....|....*....|....*...
gi 490930577 1303 QETSYRLSAELGAKLQHKLRQQGITLNVFMQMIWAMTL 1340
Cdd:COG1020  1291 TARALALLLLLALLLLLALALALLLLLLLLLALLLLAL 1328

A_NRPS_AB3403-like

cd17646

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...

1537-2031

0e+00

Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 620.45 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1537 LLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQH 1616
Cdd:cd17646     3 LVAEQAARTPDAPAVVDEGRTLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDPGY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1617 PTERIKFMLQDAKSKLVIGEQKDLAAIVHPSIATFAFNELFDETKVDLssyKTTVITPQHPAYLIYTSGTTGQPKGVMVS 1696
Cdd:cd17646    83 PADRLAYMLADAGPAVVLTTADLAARLPAGGDVALLGDEALAAPPATP---PLVPPRPDNLAYVIYTSGSTGRPKGVMVT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1697 HQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSM 1776
Cdd:cd17646   160 HAGIVNRLLWMQDEYPLGPGDRVLQKTPLSFDVSVWELFWPLVAGARLVVARPGGHRDPAYLAALIREHGVTTCHFVPSM 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1777 LAVFENAATeilsSAQRQSLPicRVFCSGEALPTALAKSFTEHFSCELHNLYGPTEAAVDVSYMDATlGLHPEEScVAIG 1856
Cdd:cd17646   240 LRVFLAEPA----AGSCASLR--RVFCSGEALPPELAARFLALPGAELHNLYGPTEAAIDVTHWPVR-GPAETPS-VPIG 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1857 YPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADGSIQYIGRA 1936
Cdd:cd17646   312 RPVPNTRLYVLDDALRPVPVGVPGELYLGGVQLARGYLGRPALTAERFVPDPFGPGSRMYRTGDLARWRPDGALEFLGRS 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1937 DDQLKIRGQRIELGEIEQQLR---LISGLDVVVHaissEQNKANVQLVAYLQ---TTAPVDIDQLKKQLAKHLPAYMVPT 2010
Cdd:cd17646   392 DDQVKIRGFRVEPGEIEAALAahpAVTHAVVVAR----AAPAGAARLVGYVVpaaGAAGPDTAALRAHLAERLPEYMVPA 467

                         490       500
                  ....*....|....*....|.
gi 490930577 2011 HYMLVEQFPLSHNGKLDRKAL 2031
Cdd:cd17646   468 AFVVLDALPLTANGKLDRAAL 488

A_NRPS

cd05930

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...

1546-2031

0e+00

Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 594.89 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1546 PEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFML 1625
Cdd:cd05930     1 PDAVAVVDGDQSLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSYPAERLAYIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1626 QDAKSKLVIGEqkdlaaivhpsiatfafnelfdetkvdlssykttvitPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRIL 1705
Cdd:cd05930    81 EDSGAKLVLTD-------------------------------------PDDLAYVIYTSGSTGKPKGVMVEHRGLVNLLL 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1706 WMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSMLAVFENAAT 1785
Cdd:cd05930   124 WMQEAYPLTPGDRVLQFTSFSFDVSVWEIFGALLAGATLVVLPEEVRKDPEALADLLAEEGITVLHLTPSLLRLLLQELE 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1786 EILSSAQRqslpicRVFCSGEALPTALAKSFTEHFS-CELHNLYGPTEAAVDVSYMDATLGlHPEESCVAIGYPVWNTQL 1864
Cdd:cd05930   204 LAALPSLR------LVLVGGEALPPDLVRRWRELLPgARLVNLYGPTEATVDATYYRVPPD-DEEDGRVPIGRPIPNTRV 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1865 YILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADGSIQYIGRADDQLKIRG 1944
Cdd:cd05930   277 YVLDENLRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPNPFGPGERMYRTGDLVRWLPDGNLEFLGRIDDQVKIRG 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1945 QRIELGEIEQQLRLISGL-DVVVHAIssEQNKANVQLVAY--LQTTAPVDIDQLKKQLAKHLPAYMVPTHYMLVEQFPLS 2021
Cdd:cd05930   357 YRIELGEIEAALLAHPGVrEAAVVAR--EDGDGEKRLVAYvvPDEGGELDEEELRAHLAERLPDYMVPSAFVVLDALPLT 434

                         490
                  ....*....|
gi 490930577 2022 HNGKLDRKAL 2031
Cdd:cd05930   435 PNGKVDRKAL 444

PRK12316

peptide synthase; Provisional

1039-2120

8.75e-178

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 611.19 E-value: 8.75e-178

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1039 CTQLRQRGysLRPSDVfqfktvaamapQLTRLDEQQAAvSKPLFSADLEQkvqekygknstILPLLPLQKGMLFLSQVEN 1118
Cdd:PRK12316 4066 CCDAERHG--VTPSDF-----------PLAGLDQARLD-ALPLPLGEIED-----------IYPLSPMQQGMLFHSLYEQ 4120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1119 QS-NYNAFTRLSLNGdIDPVRLQQALITVLKRHPQLGGHFDSELA-EEPVFIYSLHPTQAWPVQFCSVTPDL---LEQTI 1193
Cdd:PRK12316 4121 EAgDYINQMRVDVQG-LDVERFRAAWQAALDRHDVLRSGFVWQGElGRPLQVVHKQVSLPFAELDWRGRADLqaaLDALA 4199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1194 QEALQQPIHLDQPyGLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYqqTNQQLPVLEHSYETVIKALSGR 1273
Cdd:PRK12316 4200 AAERERGFDLQRA-PLLRLVLVRTAEGRHHLIYTNHHILMDGWSNSQLLGEVLERY--SGRPPAQPGGRYRDYIAWLQRQ 4276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1274 DHETSKVIWQRDLADLQ-PLILFNQAQQA-------VQETSYRLSAELGAKLQHKLRQQGITLNVFMQMIWAMTLNIYAH 1345
Cdd:PRK12316 4277 DAAASEAFWREQLAALDePTRLAQAIARAdlrsangYGEHVRELDATATARLREFARTQRVTLNTLVQAAWLLLLQRYTG 4356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1346 REDIVFGTPVSGRSAPINGLEQQIGLFLNTIPVRVKLNMQQTLWEQLPQLQQLHVEHLEHDGLGLSAIQQLIAQGN--LF 1423
Cdd:PRK12316 4357 QDTVAFGATVAGRPAELPGIEGQIGLFINTLPVIATPRAQQSVVEWLQQVQRQNLALREHEHTPLYEIQRWAGQGGeaLF 4436

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1424 DSLLVVENYPDNQYLQQKL-GDAAISKLTNRGYSHYPLALLVIPDHQIELLLE-QRGVIDQP--EHFLERMIQLIEIALN 1499
Cdd:PRK12316 4437 DSLLVFENYPVSEALQQGApGGLRFGEVTNHEQTNYPLTLAVGLGETLSLQFSyDRGHFDAAtiERLARHLTNLLEAMAE 4516

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1500 EPETSLSHYR-LQLAEEHDLIQKTNQTQY-YVRQSTLQQLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRA 1577
Cdd:PRK12316 4517 DPQRRLGELQlLEKAEQQRIVALWNRTDAgYPATRCVHQLVAERARMTPDAVAVVFDEEKLTYAELNRRANRLAHALIAR 4596

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1578 GVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFMLQDAKSKLVIGEQKDLAAIVHPS-IATFAFNEl 1656
Cdd:PRK12316 4597 GVGPEVLVGIAMERSAEMMVGLLAVLKAGGAYVPLDPEYPRERLAYMMEDSGAALLLTQSHLLQRLPIPDgLASLALDR- 4675

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1657 fDETKVDLSSYKTTV-ITPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFF 1735
Cdd:PRK12316 4676 -DEDWEGFPAHDPAVrLHPDNLAYVIYTSGSTGRPKGVAVSHGSLVNHLHATGERYELTPDDRVLQFMSFSFDGSHEGLY 4754

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1736 WSYLVGARLVIAPIDAHrDPLALLSLIQKYQVTTLHFVPSMLAVFENAAteilsSAQRQSLPICRVFCSGEAL-PTALAK 1814
Cdd:PRK12316 4755 HPLINGASVVIRDDSLW-DPERLYAEIHEHRVTVLVFPPVYLQQLAEHA-----ERDGEPPSLRVYCFGGEAVaQASYDL 4828

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1815 SFTEHFSCELHNLYGPTEAAVDVSYMDATLGLHPEESCVAIGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYL 1894
Cdd:PRK12316 4829 AWRALKPVYLFNGYGPTETTVTVLLWKARDGDACGAAYMPIGTPLGNRSGYVLDGQLNPLPVGVAGELYLGGEGVARGYL 4908

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1895 HRADLTASRFVANPFTA-GQRMYRTGDIARWHADGSIQYIGRADDQLKIRGQRIELGEIEQQLRlisGLDVVVHAISSEQ 1973
Cdd:PRK12316 4909 ERPALTAERFVPDPFGApGGRLYRTGDLARYRADGVIDYLGRVDHQVKIRGFRIELGEIEARLR---EHPAVREAVVIAQ 4985

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1974 NKA-NVQLVAYL--QTTAPVDI--------DQLKKQLAKHLPAYMVPTHYMLVEQFPLSHNGKLDRKALPQPhlTPSNTE 2042
Cdd:PRK12316 4986 EGAvGKQLVGYVvpQDPALADAdeaqaelrDELKAALRERLPEYMVPAHLVFLARMPLTPNGKLDRKALPQP--DASLLQ 5063

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2043 KQYAT--SAFEHELTRIFQQILNTDQnIGVNEDFFAIGGHSILVMKLAIEIRKVFKRTIPIGQLMSHVTIQRLAALLLTQ 2120
Cdd:PRK12316 5064 QAYVAprSELEQQVAAIWAEVLQLER-VGLDDNFFELGGHSLLAIQVTSRIQLELGLELPLRELFQTPTLAAFVELAAAA 5142

PRK12316

peptide synthase; Provisional

1039-2135

1.37e-176

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 607.34 E-value: 1.37e-176

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1039 CTQLRQRGYSlrPSDVfqfktvaamapQLTRLDEQQAAvSKPLFSADLEQkvqekygknstILPLLPLQKGMLFLSQVEN 1118
Cdd:PRK12316 1520 CCDERNRGVT--PSDF-----------PLAGLSQAQLD-ALPLPAGEIAD-----------IYPLSPMQQGMLFHSLYEQ 1574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1119 QS-NYNAFTRLSLNGdIDPVRLQQALITVLKRHPQL--GGHFDSELaEEPVFIysLHPTQAWPvqfCSVTPDLLEQTIQE 1195
Cdd:PRK12316 1575 EAgDYINQLRVDVQG-LDPDRFRAAWQATVDRHEILrsGFLWQDGL-EQPLQV--IHKQVELP---FAELDWRGREDLGQ 1647

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1196 ALQQPIHLDQPYG-------LIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYqqTNQQLPVLEHSYETVIK 1268
Cdd:PRK12316 1648 ALDALAQAERQKGfdltrapLLRLVLVRTGEGRHHLIYTNHHILMDGWSNAQLLGEVLQRY--AGQPVAAPGGRYRDYIA 1725

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1269 ALSGRDHETSKVIWQRDLADLQ-PLILFNQAQQAVQETSY-----RLSAELGAKLQHKLRQQGITLNVFMQMIWAMTLNI 1342
Cdd:PRK12316 1726 WLQRQDAAASEAFWKEQLAALEePTRLAQAARTEDGQVGYgdhqqLLDPAQTRALAEFARAQKVTLNTLVQAAWLLLLQR 1805

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1343 YAHREDIVFGTPVSGRSAPINGLEQQIGLFLNTIPVRVKLNMQQTLWEQLPQLQQLHVEHLEHDGLGLSAIQQLIAQGN- 1421
Cdd:PRK12316 1806 YTGQETVAFGATVAGRPAELPGIEQQIGLFINTLPVIAAPRPDQSVADWLQEVQALNLALREHEHTPLYDIQRWAGQGGe 1885

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1422 -LFDSLLVVENYPDNQYLQQKL-GDAAISKLTNRGYSHYPLALLVIPDHQIELLLE-QRGVID--QPEHFLERMIQLIEI 1496
Cdd:PRK12316 1886 aLFDSLLVFENYPVAEALKQGApAGLVFGRVSNHEQTNYPLTLAVTLGETLSLQYSyDRGHFDaaAIERLDRHLLHLLEQ 1965

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1497 ALNEPETSLSHYRLQLAEEHDLIQK--TNQTQYYVRQSTLQQLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQL 1574
Cdd:PRK12316 1966 MAEDAQAALGELALLDAGERQRILAdwDRTPEAYPRGPGVHQRIAEQAARAPEAIAVVFGDQHLSYAELDSRANRLAHRL 2045

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1575 QRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFMLQDAKSKLVIGEQKDLAAIVHP-SIATFAF 1653
Cdd:PRK12316 2046 RARGVGPEVRVAIAAERSFELVVALLAVLKAGGAYVPLDPNYPAERLAYMLEDSGAALLLTQRHLLERLPLPaGVARLPL 2125

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1654 nelfdETKVDLSSYKTTV----ITPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDV 1729
Cdd:PRK12316 2126 -----DRDAEWADYPDTApavqLAGENLAYVIYTSGSTGLPKGVAVSHGALVAHCQAAGERYELSPADCELQFMSFSFDG 2200

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1730 SVWEFFWSYLVGARLVIAPiDAHRDPLALLSLIQKYQVTTLHFVPSMLAVF-ENAATEilssaqRQSLPICRVFCSGEAL 1808
Cdd:PRK12316 2201 AHEQWFHPLLNGARVLIRD-DELWDPEQLYDEMERHGVTILDFPPVYLQQLaEHAERD------GRPPAVRVYCFGGEAV 2273

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1809 PTALAKSFTEHFSCE-LHNLYGPTEAAVDVSYMDAtlglHPEESC----VAIGYPVWNTQLYILDQYLRPVPVGVDGELY 1883
Cdd:PRK12316 2274 PAASLRLAWEALRPVyLFNGYGPTEAVVTPLLWKC----RPQDPCgaayVPIGRALGNRRAYILDADLNLLAPGMAGELY 2349

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1884 LAGHQLAMGYLHRADLTASRFVANPFTA-GQRMYRTGDIARWHADGSIQYIGRADDQLKIRGQRIELGEIEQQLRLISGL 1962
Cdd:PRK12316 2350 LGGEGLARGYLNRPGLTAERFVPDPFSAsGERLYRTGDLARYRADGVVEYLGRIDHQVKIRGFRIELGEIEARLQAHPAV 2429

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1963 -DVVVHAISSEQNKanvQLVAYL--QTTAPVDIDQLKKQLAKHLPAYMVPTHYMLVEQFPLSHNGKLDRKALPQPHLTPS 2039
Cdd:PRK12316 2430 rEAVVVAQDGASGK---QLVAYVvpDDAAEDLLAELRAWLAARLPAYMVPAHWVVLERLPLNPNGKLDRKALPKPDVSQL 2506

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2040 NTEKQYATSAFEHELTRIFQQILNTDQnIGVNEDFFAIGGHSILVMKLAIEIRKVFKRTIPIGQLMSHVTIQRLAALLLT 2119
Cdd:PRK12316 2507 RQAYVAPQEGLEQRLAAIWQAVLKVEQ-VGLDDHFFELGGHSLLATQVVSRVRQDLGLEVPLRILFERPTLAAFAASLES 2585

                        1130
                  ....*....|....*....
gi 490930577 2120 QER---LAEVEQTGMQPIL 2135
Cdd:PRK12316 2586 GQTsraPVLQKVTRVQPLP 2604

PRK05691

peptide synthase; Validated

487-2145

2.42e-175

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 603.31 E-value: 2.42e-175

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  487 PERTAI--VSGERPNLQHLSFAELAVKVNQLTRFLQENGARKQTVIAgAIPRSIDSVVVMLSVLNSGASFLPLdldYP-- 562
Cdd:PRK05691   23 PDRLALrfLADDPGEGVVLSYRDLDLRARTIAAALQARASFGDRAVL-LFPSGPDYVAAFFGCLYAGVIAVPA---YPpe 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  563 ------IDRMQMMCEDANPLFVLTTQALAQQLpQNIQQLHLDQEGVQTQIRKQDASdiPAEN-RKFDFQ--DVAYVIFTS 633
Cdd:PRK05691   99 sarrhhQERLLSIIADAEPRLLLTVADLRDSL-LQMEELAAANAPELLCVDTLDPA--LAEAwQEPALQpdDIAFLQYTS 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  634 GSTGRPKGVMNTHGSLL-----------------NLILSHKP---------TIYWPVLEAV------NERFPDRPLRaah 681
Cdd:PRK05691  176 GSTALPKGVQVSHGNLVaneqlirhgfgidlnpdDVIVSWLPlyhdmgligGLLQPIFSGVpcvlmsPAYFLERPLR--- 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  682 thsfsfdssWLQVFWMLWG-------------------QELHIFDENMRRDAFGLVQEIQQrqiDTLDLppsFCAQMMTN 742
Cdd:PRK05691  253 ---------WLEAISEYGGtisggpdfayrlcservseSALERLDLSRWRVAYSGSEPIRQ---DSLER---FAEKFAAC 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  743 GlFVENQHHPS-------LILIGGE--AAPLALwqQLNAQPalFAHNLYGPTEYTVdtfraeLKQTARPVIGNPIgntqA 813
Cdd:PRK05691  318 G-FDPDSFFASyglaeatLFVSGGRrgQGIPAL--ELDAEA--LARNRAEPGTGSV------LMSCGRSQPGHAV----L 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  814 YVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVanpfEH-GQRMYRTGDLvRWNSAGKLEFMGRCDDQIKIR 892
Cdd:PRK05691  383 IVDPQSLEVLGDNRVGEIWASGPSIAHGYWRNPEASAKTFV----EHdGRTWLRTGDL-GFLRDGELFVTGRLKDMLIVR 457

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  893 GYRVEIGEVENAlsiltnVESAVviaePINNSHRLLGYCVVKD--------IELDEKTSEQLSQQYL-SQLRQNLPE--Y 961
Cdd:PRK05691  458 GHNLYPQDIEKT------VEREV----EVVRKGRVAAFAVNHQgeegigiaAEISRSVQKILPPQALiKSIRQAVAEacQ 527

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  962 MVPSALTVMS--EFPRNVSGKVDKKA---------------LPKPQiRAHSRMAETPEQQLLCQITA---SVLKLDAIGI 1021
Cdd:PRK05691  528 EAPSVVLLLNpgALPKTSSGKLQRSAcrlrladgsldsyalFPALQ-AVEAAQTAASGDELQARIAAiwcEQLKVEQVAA 606

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1022 DDDFFMTGGDSISAIMLCTQLRQR-GYSLRPSDVFQFKTVAAMAPQLTRLDEQQAAVSKPLFSADLEQKvqekygknsti 1100
Cdd:PRK05691  607 DDHFFLLGGNSIAATQVVARLRDElGIDLNLRQLFEAPTLAAFSAAVARQLAGGGAAQAAIARLPRGQA----------- 675

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1101 LPLLPLQKGMLFLSQVENQSN-YNAFTRLSLNGDIDPVRLQQALITVLKRHPQLGGHFDSElaeEPVFIYSLHPTQAWPV 1179
Cdd:PRK05691  676 LPQSLAQNRLWLLWQLDPQSAaYNIPGGLHLRGELDEAALRASFQRLVERHESLRTRFYER---DGVALQRIDAQGEFAL 752

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1180 QFCSVTpDLLE-------QTIQEA-LQQPIHLDQ-PygLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYQ 1250
Cdd:PRK05691  753 QRIDLS-DLPEaerearaAQIREEeARQPFDLEKgP--LLRVTLVRLDDEEHQLLVTLHHIVADGWSLNILLDEFSRLYA 829

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1251 QTNQ----QLPVLEHSY----ETVIKALSGRDHETSKVIWQRDLADLQPLILFN-------QAQQAVQETSYRLSAELGA 1315
Cdd:PRK05691  830 AACQgqtaELAPLPLGYadygAWQRQWLAQGEAARQLAYWKAQLGDEQPVLELAtdhprsaRQAHSAARYSLRVDASLSE 909

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1316 KLQHKLRQQGITLNVFMQMIWAMTLNIYAHREDIVFGTPVSGRsaPINGLEQQIGLFLNTIPVRVKLNMQQTLWEQLPQL 1395
Cdd:PRK05691  910 ALRGLAQAHQATLFMVLLAAFQALLHRYSGQGDIRIGVPNANR--PRLETQGLVGFFINTQVLRAQLDGRLPFTALLAQV 987

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1396 QQLHVEHLEHDGLGLSAIQQLIAQGNLFDSLLVVENYP--DNQYLQQKLGDAAISKLTNRGYSHYPLALLVIPDHQIEL- 1472
Cdd:PRK05691  988 RQATLGAQAHQDLPFEQLVEALPQAREQGLFQVMFNHQqrDLSALRRLPGLLAEELPWHSREAKFDLQLHSEEDRNGRLt 1067

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1473 --------LLEQRGVIDQPEHFLermiQLIEIALNEPETSLSHYRLQLAEEHDLIQKTNQTQYYVRQSTLQQLLREQARI 1544
Cdd:PRK05691 1068 lsfdyaaeLFDAATIERLAEHFL----ALLEQVCEDPQRALGDVQLLDAAERAQLAQWGQAPCAPAQAWLPELLNEQARQ 1143

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1545 TPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFM 1624
Cdd:PRK05691 1144 TPERIALVWDGGSLDYAELHAQANRLAHYLRDKGVGPDVCVAIAAERSPQLLVGLLAILKAGGAYVPLDPDYPAERLAYM 1223

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1625 LQDAKSKLVIGEQKDLAAIVHPS-IATFAFNELfdetkvDLSSYKTTV----ITPQHPAYLIYTSGTTGQPKGVMVSHQA 1699
Cdd:PRK05691 1224 LADSGVELLLTQSHLLERLPQAEgVSAIALDSL------HLDSWPSQApglhLHGDNLAYVIYTSGSTGQPKGVGNTHAA 1297

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1700 IVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSMLAV 1779
Cdd:PRK05691 1298 LAERLQWMQATYALDDSDVLMQKAPISFDVSVWECFWPLITGCRLVLAGPGEHRDPQRIAELVQQYGVTTLHFVPPLLQL 1377

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1780 F--ENAATEILSsaqrqslpICRVFCSGEALPTALAKSFTEHF-SCELHNLYGPTEAAVDVSYMDATLGlhpEESCVAIG 1856
Cdd:PRK05691 1378 FidEPLAAACTS--------LRRLFSGGEALPAELRNRVLQRLpQVQLHNRYGPTETAINVTHWQCQAE---DGERSPIG 1446

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1857 YPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPF-TAGQRMYRTGDIARWHADGSIQYIGR 1935
Cdd:PRK05691 1447 RPLGNVLCRVLDAELNLLPPGVAGELCIGGAGLARGYLGRPALTAERFVPDPLgEDGARLYRTGDRARWNADGALEYLGR 1526

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1936 ADDQLKIRGQRIELGEIEQQLRLISGLD---VVVHaisseQNKANVQLVAYLQTTAPVDI--DQLKKQLAKHLPAYMVPT 2010
Cdd:PRK05691 1527 LDQQVKLRGFRVEPEEIQARLLAQPGVAqaaVLVR-----EGAAGAQLVGYYTGEAGQEAeaERLKAALAAELPEYMVPA 1601

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2011 HYMLVEQFPLSHNGKLDRKALPQP------HLTPSntekqyatSAFEHELTRIFQQILNTDQnIGVNEDFFAIGGHSILV 2084
Cdd:PRK05691 1602 QLIRLDQMPLGPSGKLDRRALPEPvwqqreHVEPR--------TELQQQIAAIWREVLGLPR-VGLRDDFFALGGHSLLA 1672

                        1770      1780      1790      1800      1810      1820
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490930577 2085 MKLAIEIRKVFKRTIPIGQLMSHVTIQRLAALLLTQErlAEVEQTGMQPILPIRSGSGHPL 2145
Cdd:PRK05691 1673 TQIVSRTRQACDVELPLRALFEASELGAFAEQVARIQ--AAGERNSQGAIARVDRSQPVPL 1731

PRK12467

peptide synthase; Provisional

1101-2134

7.25e-171

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 589.44 E-value: 7.25e-171

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1101 LPLLPLQKGMLFLSQVENQS-NYNAFTRLSLNGDIDPVRLQQALITVLKRHPQLGGHFDSElaeEPVFIYSLHPTQAWPV 1179
Cdd:PRK12467   50 IPLSYAQERQWFLWQLDPDSaAYNIPTALRLRGELDVSALRRAFDALVARHESLRTRFVQD---EEGFRQVIDASLSLTI 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1180 QFCSVTPD-------LLEQTIQEALQQPIHLdQPYGLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYQQT 1252
Cdd:PRK12467  127 PLDDLANEqgraresQIEAYINEEVARPFDL-ANGPLLRVRLLRLADDEHVLVVTLHHIISDGWSMRVLVEELVQLYSAY 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1253 NQ----QLPVLEHSYETVikALSGR------DHETSKVIWQRDLADLQPLILF-----NQAQQAVQETSYRLS--AELGA 1315
Cdd:PRK12467  206 SQgrepSLPALPIQYADY--AIWQRswleagERERQLAYWQEQLGGEHTVLELptdrpRPAVPSYRGARLRVDlpQALSA 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1316 KLQHKLRQQGITLNVFMQMIWAMTLNIYAHREDIVFGTPVSGRSApiNGLEQQIGLFLNTIPVRVKLNMQQTLWEQLPQL 1395
Cdd:PRK12467  284 GLKALAQREGVTLFMVLLASFQTLLHRYSGQSDIRIGVPNANRNR--VETERLIGFFVNTQVLKAEVDPQASFLELLQQV 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1396 QQLHVEHLEHDGLGLSA-IQQLIAQGNLFDSLL--VVENY-PDNQYLQQKLGdAAISKLT------NRGYSHYPLALLVI 1465
Cdd:PRK12467  362 KRTALGAQAHQDLPFEQlVEALQPERSLSHSPLfqVMFNHqNTATGGRDREG-AQLPGLTveelswARHTAQFDLALDTY 440

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1466 PDHQ---IEL-----LLEQRGVIDQPEHFLErmiqLIEIALNEPETSLSHYRLQLAEEH-DLIQKTNQTQYYVRQSTLQQ 1536
Cdd:PRK12467  441 ESAQglwAAFtyatdLFEATTIERLATHWRN----LLEAIVAEPRRRLGELPLLDAEERaRELVRWNAPATEYAPDCVHQ 516

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1537 LLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQH 1616
Cdd:PRK12467  517 LIEAQARQHPERPALVFGEQVLSYAELNRQANRLAHVLIAAGVGPDVLVGIAVERSIEMVVGLLAVLKAGGAYVPLDPEY 596

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1617 PTERIKFMLQDAKSKLVIGEQKDLAAIVHP-SIATFAFNELFDETKVDLSSYKTTVITPQHPAYLIYTSGTTGQPKGVMV 1695
Cdd:PRK12467  597 PQDRLAYMLDDSGVRLLLTQSHLLAQLPVPaGLRSLCLDEPADLLCGYSGHNPEVALDPDNLAYVIYTSGSTGQPKGVAI 676

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1696 SHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPS 1775
Cdd:PRK12467  677 SHGALANYVCVIAERLQLAADDSMLMVSTFAFDLGVTELFGALASGATLHLLPPDCARDAEAFAALMADQGVTVLKIVPS 756

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1776 MLAVFenaateILSSAQRQSLPICRVFCSGEALPTAL-AKSFTEHFSCELHNLYGPTEAAVDVSYMDATlGLHPEESCVA 1854
Cdd:PRK12467  757 HLQAL------LQASRVALPRPQRALVCGGEALQVDLlARVRALGPGARLINHYGPTETTVGVSTYELS-DEERDFGNVP 829

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1855 IGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPF-TAGQRMYRTGDIARWHADGSIQYI 1933
Cdd:PRK12467  830 IGQPLANLGLYILDHYLNPVPVGVVGELYIGGAGLARGYHRRPALTAERFVPDPFgADGGRLYRTGDLARYRADGVIEYL 909

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1934 GRADDQLKIRGQRIELGEIEQQLRLISGL-DVVVHAISSEqnkANVQLVAYLQTTAPVD-------IDQLKKQLAKHLPA 2005
Cdd:PRK12467  910 GRMDHQVKIRGFRIELGEIEARLLAQPGVrEAVVLAQPGD---AGLQLVAYLVPAAVADgaehqatRDELKAQLRQVLPD 986

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2006 YMVPTHYMLVEQFPLSHNGKLDRKALPQPHLTPSNTEKQYATSAFEHELTRIFQQILNTDQnIGVNEDFFAIGGHSILVM 2085
Cdd:PRK12467  987 YMVPAHLLLLDSLPLTPNGKLDRKALPKPDASAVQATFVAPQTELEKRLAAIWADVLKVER-VGLTDNFFELGGHSLLAT 1065

                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|....*....
gi 490930577 2086 KLAIEIRKVFKRTIPIGQLMSHVTIQRLAALLLTQerlAEVEQTGMQPI 2134
Cdd:PRK12467 1066 QVISRVRQRLGIQVPLRTLFEHQTLAGFAQAVAAQ---QQGAQPALPDV 1111

PRK12316

peptide synthase; Provisional

1101-2139

7.48e-170

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 586.54 E-value: 7.48e-170

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1101 LPLLPLQKGMLFLSQVENQSN-YNAFTRLSLNGDIDPVRLQQALITVLKRHPQLGGHFDSELAEEPVFIYSLHPTQAWPV 1179
Cdd:PRK12316   50 DRLSYAQQRMWFLWQLEPQSGaYNLPSAVRLNGPLDRQALERAFASLVQRHETLRTVFPRGADDSLAQVPLDRPLEVEFE 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1180 QFCSVTPDLLEQTIQEALQ----QPIHLDQ-PygLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYQ--QT 1252
Cdd:PRK12316  130 DCSGLPEAEQEARLRDEAQreslQPFDLCEgP--LLRVRLLRLGEEEHVLLLTLHHIVSDGWSMNVLIEEFSRFYSayAT 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1253 NQ--QLPVLEHSYETVikALSGR------DHETSKVIWQRDLADLQPLILF-----NQAQQAVQETSYRLSAE--LGAKL 1317
Cdd:PRK12316  208 GAepGLPALPIQYADY--ALWQRswleagEQERQLEYWRAQLGEEHPVLELptdhpRPAVPSYRGSRYEFSIDpaLAEAL 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1318 QHKLRQQGITLnvFMQMI--WAMTLNIYAHREDIVFGTPVSGRS-APINGLeqqIGLFLNTIPVRVKLNMQQTLWEQLPQ 1394
Cdd:PRK12316  286 RGTARRQGLTL--FMLLLgaFNVLLHRYSGQTDIRVGVPIANRNrAEVEGL---IGFFVNTQVLRSVFDGRTRVATLLAG 360

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1395 LQQlHVehlehdgLGLSAIQQLIAQgNLFDSLLVVENYPDNQYLQQKLGD----AAISKLTnrGYSHYPLALLVIPDH-- 1468
Cdd:PRK12316  361 VKD-TV-------LGAQAHQDLPFE-RLVEALKVERSLSHSPLFQVMYNHqplvADIEALD--TVAGLEFGQLEWKSRtt 429

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1469 QIELLL---EQRGVIDQPEHF---------LERM----IQLIEIALNEPETSLSHYRLQLAEEH-DLIQKTNQT-QYYVR 1530
Cdd:PRK12316  430 QFDLTLdtyEKGGRLHAALTYatdlfeartVERMarhwQNLLRGMVENPQARVDELPMLDAEERgQLVEGWNATaAEYPL 509

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1531 QSTLQQLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYL 1610
Cdd:PRK12316  510 QRGVHRLFEEQVERTPEAPALAFGEETLDYAELNRRANRLAHALIERGVGPDVLVGVAMERSIEMVVALLAILKAGGAYV 589

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1611 PIDLQHPTERIKFMLQDAKSKLVIGEQKDLAAIvhpSIATFAFNELFDETKVDLSSYKT----TVITPQHPAYLIYTSGT 1686
Cdd:PRK12316  590 PLDPEYPAERLAYMLEDSGVQLLLSQSHLGRKL---PLAAGVQVLDLDRPAAWLEGYSEenpgTELNPENLAYVIYTSGS 666

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1687 TGQPKGVMVSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQ 1766
Cdd:PRK12316  667 TGKPKGAGNRHRALSNRLCWMQQAYGLGVGDTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVELINREG 746

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1767 VTTLHFVPSMLAVFENAAteilssAQRQSLPICRVFCSGEALPTALAKS-FTEHFSCELHNLYGPTEAAVDVSYMDATlg 1845
Cdd:PRK12316  747 VDTLHFVPSMLQAFLQDE------DVASCTSLRRIVCSGEALPADAQEQvFAKLPQAGLYNLYGPTEAAIDVTHWTCV-- 818

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1846 lhpEE--SCVAIGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIAR 1923
Cdd:PRK12316  819 ---EEggDSVPIGRPIANLACYILDANLEPVPVGVLGELYLAGRGLARGYHGRPGLTAERFVPSPFVAGERMYRTGDLAR 895

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1924 WHADGSIQYIGRADDQLKIRGQRIELGEIEQQLRLISGL-DVVVHAISSEqnkanvQLVAY--LQTTAPVDIDQLKKQLA 2000
Cdd:PRK12316  896 YRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVrEAAVLAVDGK------QLVGYvvLESEGGDWREALKAHLA 969

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 2001 KHLPAYMVPTHYMLVEQFPLSHNGKLDRKALPQPHLTPSNTEKQYATSAFEHELTRIFQQILNTdQNIGVNEDFFAIGGH 2080
Cdd:PRK12316  970 ASLPEYMVPAQWLALERLPLTPNGKLDRKALPAPEASVAQQGYVAPRNALERTLAAIWQDVLGV-ERVGLDDNFFELGGD 1048

                        1050      1060      1070      1080      1090      1100
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490930577 2081 SILVMKLAIEIRKVFKRTIPiGQLMSHVTIQRLaALLLTQERLAEVEQ---TGMQPILPIRS 2139
Cdd:PRK12316 1049 SIVSIQVVSRARQAGIQLSP-RDLFQHQTIRSL-ALVAKAGQATAADQgpaSGEVALAPVQR 1108

A_NRPS

cd05930

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...

487-986

2.13e-158

Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 497.05 E-value: 2.13e-158

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  487 PERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRM 566
Cdd:cd05930     1 PDAVAVVDGD----QSLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSYPAERL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  567 QMMCEDANPLFVLTTQalaqqlpqniqqlhldqegvqtqirkqdasdipaenrkfdfQDVAYVIFTSGSTGRPKGVMNTH 646
Cdd:cd05930    77 AYILEDSGAKLVLTDP-----------------------------------------DDLAYVIYTSGSTGKPKGVMVEH 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  647 GSLLNLILSHkptiywpvleavNERFPDRP-LRAAHTHSFSFDSSWLQVFWML-WGQELHIFDENMRRDAFGLVQEIQQR 724
Cdd:cd05930   116 RGLVNLLLWM------------QEAYPLTPgDRVLQFTSFSFDVSVWEIFGALlAGATLVVLPEEVRKDPEALADLLAEE 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  725 QIDTLDLPPSFCAQMMTNGlfvENQHHPSL--ILIGGEAAPLALWQQLNAQ-PALFAHNLYGPTEYTVD-TF---RAELK 797
Cdd:cd05930   184 GITVLHLTPSLLRLLLQEL---ELAALPSLrlVLVGGEALPPDLVRRWRELlPGARLVNLYGPTEATVDaTYyrvPPDDE 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  798 QTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQRMYRTGDLVRWNSAG 877
Cdd:cd05930   261 EDGRVPIGRPIPNTRVYVLDENLRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPNPFGPGERMYRTGDLVRWLPDG 340

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  878 KLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSH-RLLGYCVVKDieldekTSEQLSQQYLSQLRQ 956
Cdd:cd05930   341 NLEFLGRIDDQVKIRGYRIELGEIEAALLAHPGVREAAVVAREDGDGEkRLVAYVVPDE------GGELDEEELRAHLAE 414

                         490       500       510
                  ....*....|....*....|....*....|
gi 490930577  957 NLPEYMVPSALTVMSEFPRNVSGKVDKKAL 986
Cdd:cd05930   415 RLPDYMVPSAFVVLDALPLTPNGKVDRKAL 444

A_NRPS_Ta1_like

cd12116

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ...

1546-2031

6.99e-156

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.

Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 491.42 E-value: 6.99e-156

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1546 PEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFML 1625
Cdd:cd12116     1 PDATAVRDDDRSLSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRLRYIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1626 QDAKSKLVIGEQKDLAAIVHPSIATFAFNElfdETKVDLSSYKTTViTPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRIL 1705
Cdd:cd12116    81 EDAEPALVLTDDALPDRLPAGLPVLLLALA---AAAAAPAAPRTPV-SPDDLAYVIYTSGSTGRPKGVVVSHRNLVNFLH 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1706 WMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPsmlavfenAAT 1785
Cdd:cd12116   157 SMRERLGLGPGDRLLAVTTYAFDISLLELLLPLLAGARVVIAPRETQRDPEALARLIEAHSITVMQATP--------ATW 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1786 EILSSAQRQSLPICRVFCSGEALPTALAKSFTEHfSCELHNLYGPTEAAVDVSYMDATLGLHPeescVAIGYPVWNTQLY 1865
Cdd:cd12116   229 RMLLDAGWQGRAGLTALCGGEALPPDLAARLLSR-VGSLWNLYGPTETTIWSTAARVTAAAGP----IPIGRPLANTQVY 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1866 ILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPF-TAGQRMYRTGDIARWHADGSIQYIGRADDQLKIRG 1944
Cdd:cd12116   304 VLDAALRPVPPGVPGELYIGGDGVAQGYLGRPALTAERFVPDPFaGPGSRLYRTGDLVRRRADGRLEYLGRADGQVKIRG 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1945 QRIELGEIEQQLRLISGLD---VVVHaisseQNKANVQLVAY--LQTTAPVDIDQLKKQLAKHLPAYMVPTHYMLVEQFP 2019
Cdd:cd12116   384 HRIELGEIEAALAAHPGVAqaaVVVR-----EDGGDRRLVAYvvLKAGAAPDAAALRAHLRATLPAYMVPSAFVRLDALP 458

                         490
                  ....*....|..
gi 490930577 2020 LSHNGKLDRKAL 2031
Cdd:cd12116   459 LTANGKLDRKAL 470

NRPS_MxcG

NF038078

myxochelin non-ribosomal peptide synthetase MxcG;

15-1079

4.50e-155

myxochelin non-ribosomal peptide synthetase MxcG;

Pssm-ID: 468336 [Multi-domain] Cd Length: 1444 Bit Score: 521.59 E-value: 4.50e-155

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   15 QPARFELASTQLGIFLADHLSSIEDLYTIAHCLELPKTVDIPTFKKAIQIGLNEADTVIASYSSDPSQPFIELNNQVQFQ 94
Cdd:NF038078    1 QEARWPLSAAQHGIWLGQQLDLASPVYNAGECIEIRGPVDPAVFEAALRQAVGEAEALHMRFVPGEEGPRQLLDPSADWP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   95 IEEFDFCHLT-PKKAQQrlwDWMPSDrqCAKSLKAGETQLFRQVLFTTH-DKVYWYQRYHHIMLDGFSMINLTKRIVELY 172
Cdd:NF038078   81 LHRVDVSGTPdPWAAAQ---AWMRED--LARTVDLSRGPLFAEALFKAApDRFFWYQRAHHIALDGFGFSLLARRVAELY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  173 QQLQEGKDlSVSPFIGVNEVISERQAYENSHQFKIDQAFWKAYCEDLPSPISLSThhlAAKTTATFVKHQLRFSTGILEQ 252
Cdd:NF038078  156 TARVTGRP-ATGGFGSLRAVLDEDAAYRAGPQCELDRAFWMERFADRPTPVSLAE---PAPMSRSFVRQTRHLSPSEMER 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  253 IQALAAQTKLALNDMMMSLSLHYIYKMTDKAELVNGIPFMRRLGSKAIRSTLPTVNVLPVKFKVAEKDSWVSLAQHVQEQ 332
Cdd:NF038078  232 LQAVARQAGLSWPDLVLAATAAWLHRRTGAPEVVLGLPVMGRLGSAALRVPCMAMNIVPLRVPVRPGAGLLALARGVAAE 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  333 LREIRPHQKYDAEQILRDLNSIDIHERMYGPILNYKAFDQDLVIDGEKVKTHHISTGPIDDFEFSFIVQD--HELIIELR 410
Cdd:NF038078  312 LRAIRPHLRYRYEQLRRDLKLVGGQRRLFGPVVNIMPFDYALRFAGMPAIAHNISAGPVEDLSIGVYARSdgRGPRVDFD 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  411 ADSQRYTQDELFNHGQRLTLLLEQALIRPEQPCSNFNITTP-------QELTALTQSGIGPRVSHPeqynnVLDIFYEQV 483
Cdd:NF038078  392 ANPACYSADELDAHQREFLQLLEALLAAPEQAVARALIPGAaapapaaSRPGSLLDGGPLPAPARP-----VLELIAERA 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  484 KKYPERTAIVSGERpnlqHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPI 563
Cdd:NF038078  467 REQPDAIAVEHGPR----RMTYRELLLAARALAARLVAAGARPDTLVAVMLPRSIDAIVASLGVLFSGAGYLPLDPFGPS 542

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  564 DRMQMMCEDANPLFVLTTQALA---QQLPQNIQQLHLDQEGVQTQIRKQDASDIPAENRkfdfqdVAYVIFTSGSTGRPK 640
Cdd:NF038078  543 SRTAAILADAAPALIVTSSEHAptaKAGPQAPGALVVRRLEEAVPSPAPEAPPRPADER------LAYVIYTSGSTGQPN 616

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  641 GVMNTHGSLLNLILShkPTIYWPVleavneRFPDRPLRAAHTHsfsFDSSWLQVFWMLW-GQELHIFDENMRRDAFGLVQ 719
Cdd:NF038078  617 GVQISRGALAHFVAG--ATQRYGV------RRDDRVLQFAPLH---FDASVEEIFLTLCaGARLVLRTDEMLQSVPRLLD 685

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  720 EIQQRQIDTLDLPPSF---CAQMMTNGLFVenqhHPS---LILIGGEAA-P--LALWQQlNAQPALFAHNLYGPTEYTVD 790
Cdd:NF038078  686 ACAEHGITVLDLPTAFwheLAYSVSTGAAR----LPSslrTVIIGGEAAlPerVARWRA-AVGPRVRLLNTYGPTEATVV 760

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  791 TFRAELKQTARPV-------IGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVA-NPFEHGQ 862
Cdd:NF038078  761 ATVATLSGGGAAGdegdevpIGRPLPGVRAALLDAQGRLVAPGAEGELYLLGGGLARGYLGRPELDAARFTTlEALPGRP 840

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  863 RMYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNV-ESAVVIAEPINNSHRLLGYCVVKDIeldEK 941
Cdd:NF038078  841 RAYRTGDLVRLREDGQLVFVGRVDDEFKISGHRIDPAEVETVLLGHPGVrEAAVVGQVLPGGTRRLCAHVVADAP---AP 917

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  942 TSEQLSQqylsQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALPKPQI---RAHSRMAETPEQQLLCQITASVLKLDA 1018
Cdd:NF038078  918 SAAELRR----HLLSALPAPMVPGAFVFAERLPRTSTGKIDRAALRRAGPaeeSATSAAAATALERVVLRVWEQVLGVSG 993

                        1050      1060      1070      1080      1090      1100
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490930577 1019 IGIDDDFFMTGGDSISAIMLCTQLR-QRGYSLRPSDVFQFKTVAAMAPQLtrldEQQAAVSK 1079
Cdd:NF038078  994 LSAQDDFFELGGQSLQSIQVANRLGvALGREVPVATVFRHPTAAGLAQAL----EHGASVAA 1051

A_NRPS_VisG_like

cd17651

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ...

1538-2032

1.86e-146

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 465.28 E-value: 1.86e-146

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1538 LREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHP 1617
Cdd:cd17651     1 FERQAARTPDAPALVAEGRRLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1618 TERIKFMLQDAKSKLVIGEQKDLAAIVHPSIATFAFNELFDETKVDLSsyKTTVITPQHPAYLIYTSGTTGQPKGVMVSH 1697
Cdd:cd17651    81 AERLAFMLADAGPVLVLTHPALAGELAVELVAVTLLDQPGAAAGADAE--PDPALDADDLAYVIYTSGSTGRPKGVVMPH 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1698 QAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLhFVPsml 1777
Cdd:cd17651   159 RSLANLVAWQARASSLGPGARTLQFAGLGFDVSVQEIFSTLCAGATLVLPPEEVRTDPPALAAWLDEQRISRV-FLP--- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1778 AVFENAATEILSSAQRQSLPICRVFCSGEALPT--ALAKSFTEHFSCELHNLYGPTEAAVDVSY-MDATLGLHPEEscVA 1854
Cdd:cd17651   235 TVALRALAEHGRPLGVRLAALRYLLTGGEQLVLteDLREFCAGLPGLRLHNHYGPTETHVVTALsLPGDPAAWPAP--PP 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1855 IGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADGSIQYIG 1934
Cdd:cd17651   313 IGRPIDNTRVYVLDAALRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPDPFVPGARMYRTGDLARWLPDGELEFLG 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1935 RADDQLKIRGQRIELGEIEQQLRLISGL-DVVVHAISSEQNKAnvQLVAYL--QTTAPVDIDQLKKQLAKHLPAYMVPTH 2011
Cdd:cd17651   393 RADDQVKIRGFRIELGEIEAALARHPGVrEAVVLAREDRPGEK--RLVAYVvgDPEAPVDAAELRAALATHLPEYMVPSA 470

                         490       500
                  ....*....|....*....|.
gi 490930577 2012 YMLVEQFPLSHNGKLDRKALP 2032
Cdd:cd17651   471 FVLLDALPLTPNGKLDRRALP 491

A_NRPS_Bac

cd17655

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ...

1536-2034

2.17e-146

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 465.26 E-value: 2.17e-146

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1536 QLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQ 1615
Cdd:cd17655     1 ELFEEQAEKTPDHTAVVFEDQTLTYRELNERANQLARTLREKGVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPIDPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1616 HPTERIKFMLQDAKSKLVIGEQKdlaaiVHPSIATFAFNELFDETkvDLSSYKTT----VITPQHPAYLIYTSGTTGQPK 1691
Cdd:cd17655    81 YPEERIQYILEDSGADILLTQSH-----LQPPIAFIGLIDLLDED--TIYHEESEnlepVSKSDDLAYVIYTSGSTGKPK 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1692 GVMVSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLH 1771
Cdd:cd17655   154 GVMIEHRGVVNLVEWANKVIYQGEHLRVALFASISFDASVTEIFASLLSGNTLYIVRKETVLDGQALTQYIRQNRITIID 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1772 FVPSMLAVFENAAteilssaQRQSLPICRVFCSGEALPTALAKSFTEHF--SCELHNLYGPTEAAVDVSYMDATLGLHPE 1849
Cdd:cd17655   234 LTPAHLKLLDAAD-------DSEGLSLKHLIVGGEALSTELAKKIIELFgtNPTITNAYGPTETTVDASIYQYEPETDQQ 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1850 EScVAIGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADGS 1929
Cdd:cd17655   307 VS-VPIGKPLGNTRIYILDQYGRPQPVGVAGELYIGGEGVARGYLNRPELTAEKFVDDPFVPGERMYRTGDLARWLPDGN 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1930 IQYIGRADDQLKIRGQRIELGEIEQQLRLISGLD-VVVHAISSEQNkaNVQLVAYLQTTAPVDIDQLKKQLAKHLPAYMV 2008
Cdd:cd17655   386 IEFLGRIDHQVKIRGYRIELGEIEARLLQHPDIKeAVVIARKDEQG--QNYLCAYIVSEKELPVAQLREFLARELPDYMI 463

                         490       500
                  ....*....|....*....|....*.
gi 490930577 2009 PTHYMLVEQFPLSHNGKLDRKALPQP 2034
Cdd:cd17655   464 PSYFIKLDEIPLTPNGKVDRKALPEP 489

A_NRPS_Srf_like

cd12117

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ...

1536-2031

4.97e-143

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.

Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 455.51 E-value: 4.97e-143

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1536 QLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQ 1615
Cdd:cd12117     1 ELFEEQAARTPDAVAVVYGDRSLTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1616 HPTERIKFMLQDAKSKLVIGEQKDLAAIVHPSIATFAFNELFDETKVDLSsyktTVITPQHPAYLIYTSGTTGQPKGVMV 1695
Cdd:cd12117    81 LPAERLAFMLADAGAKVLLTDRSLAGRAGGLEVAVVIDEALDAGPAGNPA----VPVSPDDLAYVMYTSGSTGRPKGVAV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1696 SHQAIVNriLWMQSEY-PLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVP 1774
Cdd:cd12117   157 THRGVVR--LVKNTNYvTLGPDDRVLQTSPLAFDASTFEIWGALLNGARLVLAPKGTLLDPDALGALIAEEGVTVLWLTA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1775 SMLAVFENAATEILSSAqRQslpicrVFCSGEALPTALAKSFTEHfsC---ELHNLYGPTEAAVDVSY--MDAtlgLHPE 1849
Cdd:cd12117   235 ALFNQLADEDPECFAGL-RE------LLTGGEVVSPPHVRRVLAA--CpglRLVNGYGPTENTTFTTShvVTE---LDEV 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1850 ESCVAIGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADGS 1929
Cdd:cd12117   303 AGSIPIGRPIANTRVYVLDEDGRPVPPGVPGELYVGGDGLALGYLNRPALTAERFVADPFGPGERLYRTGDLARWLPDGR 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1930 IQYIGRADDQLKIRGQRIELGEIEQQLRLISGL-DVVVHAIssEQNKANVQLVAYLQTTAPVDIDQLKKQLAKHLPAYMV 2008
Cdd:cd12117   383 LEFLGRIDDQVKIRGFRIELGEIEAALRAHPGVrEAVVVVR--EDAGGDKRLVAYVVAEGALDAAELRAFLRERLPAYMV 460

                         490       500
                  ....*....|....*....|...
gi 490930577 2009 PTHYMLVEQFPLSHNGKLDRKAL 2031
Cdd:cd12117   461 PAAFVVLDELPLTANGKVDRRAL 483

AA-adenyl-dom

amino acid adenylation domain; This model represents a domain responsible for the specific ...

1569-1966

1.63e-138

Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 439.39 E-value: 1.63e-138

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1569 ALAQQLQ-RAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFMLQDAKSKLVIGEQK--DLAAIVH 1645
Cdd:TIGR01733   11 RLARHLRaAGGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDSAlaSRLAGLV 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1646 PSIATFAFNELFDETKVDLSSYKTTVITPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRILWMQSEYPLSATDTILQKTPC 1725
Cdd:TIGR01733   91 LPVILLDPLELAALDDAPAPPPPDAPSGPDDLAYVIYTSGSTGRPKGVVVTHRSLVNLLAWLARRYGLDPDDRVLQFASL 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1726 TFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLS-LIQKYQVTTLHFVPSMLAVfenaateiLSSAQRQSLPICR-VFC 1803
Cdd:TIGR01733  171 SFDASVEEIFGALLAGATLVVPPEDEERDDAALLAaLIAEHPVTVLNLTPSLLAL--------LAAALPPALASLRlVIL 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1804 SGEALPTALAKSFTEHF-SCELHNLYGPTEAAVDVSYMDATLGLHPEESCVAIGYPVWNTQLYILDQYLRPVPVGVDGEL 1882
Cdd:TIGR01733  243 GGEALTPALVDRWRARGpGARLINLYGPTETTVWSTATLVDPDDAPRESPVPIGRPLANTRLYVLDDDLRPVPVGVVGEL 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1883 YLAGHQLAMGYLHRADLTASRFVANPF--TAGQRMYRTGDIARWHADGSIQYIGRADDQLKIRGQRIELGEIEQQLRLIS 1960
Cdd:TIGR01733  323 YIGGPGVARGYLNRPELTAERFVPDPFagGDGARLYRTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLRHP 402


                   ....*.
gi 490930577  1961 GLDVVV 1966
Cdd:TIGR01733  403 GVREAV 408

A_NRPS_Cytc1-like

cd17643

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...

1546-2031

1.82e-136

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 435.20 E-value: 1.82e-136

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1546 PEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFML 1625
Cdd:cd17643     1 PEAVAVVDEDRRLTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAFIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1626 QDAKSKLVIGEqkdlaaivhpsiatfafnelfdetkvdlssykttvitPQHPAYLIYTSGTTGQPKGVMVSHqAIVNRIL 1705
Cdd:cd17643    81 ADSGPSLLLTD-------------------------------------PDDLAYVIYTSGSTGRPKGVVVSH-ANVLALF 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1706 W-MQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSMLAVFenaa 1784
Cdd:cd17643   123 AaTQRWFGFNEDDVWTLFHSYAFDFSVWEIWGALLHGGRLVVVPYEVARSPEDFARLLRDEGVTVLNQTPSAFYQL---- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1785 TEILSSAQRQSLPICRVFCSGEALPTALAKSFTEHF---SCELHNLYGPTEAAVDVSYMDATLGLHPEESCVAIGYPVWN 1861
Cdd:cd17643   199 VEAADRDGRDPLALRYVIFGGEALEAAMLRPWAGRFgldRPQLVNMYGITETTVHVTFRPLDAADLPAAAASPIGRPLPG 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1862 TQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFT-AGQRMYRTGDIARWHADGSIQYIGRADDQL 1940
Cdd:cd17643   279 LRVYVLDADGRPVPPGVVGELYVSGAGVARGYLGRPELTAERFVANPFGgPGSRMYRTGDLARRLPDGELEYLGRADEQV 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1941 KIRGQRIELGEIEQQLRLISGL-DVVVhaISSEQNKANVQLVAYL--QTTAPVDIDQLKKQLAKHLPAYMVPTHYMLVEQ 2017
Cdd:cd17643   359 KIRGFRIELGEIEAALATHPSVrDAAV--IVREDEPGDTRLVAYVvaDDGAAADIAELRALLKELLPDYMVPARYVPLDA 436

                         490
                  ....*....|....
gi 490930577 2018 FPLSHNGKLDRKAL 2031
Cdd:cd17643   437 LPLTVNGKLDRAAL 450

PRK12316

peptide synthase; Provisional

124-1317

1.87e-135

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 477.53 E-value: 1.87e-135

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  124 KSLKAGETqlfRQVLFTThdkvywyqrYHHIMLDGFSMINLTKRIVELYQQLQEGK--DLSVSPFIGVNEVISER---QA 198
Cdd:PRK12316  166 RLLRLGEE---EHVLLLT---------LHHIVSDGWSMNVLIEEFSRFYSAYATGAepGLPALPIQYADYALWQRswlEA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  199 YENSHQFkidqAFWKAYCEDLPSPISLSTHH-LAAKTTATFVKHQLRFSTGILEQIQALAAQTKLALNDMMMSLSLHYIY 277
Cdd:PRK12316  234 GEQERQL----EYWRAQLGEEHPVLELPTDHpRPAVPSYRGSRYEFSIDPALAEALRGTARRQGLTLFMLLLGAFNVLLH 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  278 KMTDKAELVNGIPFMRRLGSKAIRSTLPTVNVLPVKFKVAEKDSWVSLAQHVQEQLREIRPHQKYDAEQILRDLNSidih 357
Cdd:PRK12316  310 RYSGQTDIRVGVPIANRNRAEVEGLIGFFVNTQVLRSVFDGRTRVATLLAGVKDTVLGAQAHQDLPFERLVEALKV---- 385

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  358 ER--MYGPILNYKAFDQDLVIDGEKVKT-HHISTGPID----DFEFSFIVQDHELIIELRAdSQRYTQDeLFN------- 423
Cdd:PRK12316  386 ERslSHSPLFQVMYNHQPLVADIEALDTvAGLEFGQLEwksrTTQFDLTLDTYEKGGRLHA-ALTYATD-LFEartverm 463

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  424 --HGQRLtllLEQALIRPEQPCSNFNITTPQELTALTQSGIGPRVSHPEQyNNVLDIFYEQVKKYPERTAIVSGErpnlQ 501
Cdd:PRK12316  464 arHWQNL---LRGMVENPQARVDELPMLDAEERGQLVEGWNATAAEYPLQ-RGVHRLFEEQVERTPEAPALAFGE----E 535

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  502 HLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRMQMMCEDANPLFVLTT 581
Cdd:PRK12316  536 TLDYAELNRRANRLAHALIERGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVPLDPEYPAERLAYMLEDSGVQLLLSQ 615

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  582 QALAQQLP--QNIQQLHLDQEGVQTQIRKQDASDIPAenrkfDFQDVAYVIFTSGSTGRPKGVMNTHGSLLNLILSHKPT 659
Cdd:PRK12316  616 SHLGRKLPlaAGVQVLDLDRPAAWLEGYSEENPGTEL-----NPENLAYVIYTSGSTGKPKGAGNRHRALSNRLCWMQQA 690

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  660 IYWPVLEAVNERFPdrplraahthsFSFDSSWLQVFWMLW-GQELHIFDENMRRDAFGLVQEIQQRQIDTLDLPPSfcaq 738
Cdd:PRK12316  691 YGLGVGDTVLQKTP-----------FSFDVSVWEFFWPLMsGARLVVAAPGDHRDPAKLVELINREGVDTLHFVPS---- 755

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  739 mMTNGLF----VENQHHPSLILIGGEAAPLALWQQLNAQ-PALFAHNLYGPTEYTVD----TFRAELKQTarPVIGNPIG 809
Cdd:PRK12316  756 -MLQAFLqdedVASCTSLRRIVCSGEALPADAQEQVFAKlPQAGLYNLYGPTEAAIDvthwTCVEEGGDS--VPIGRPIA 832

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  810 NTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQRMYRTGDLVRWNSAGKLEFMGRCDDQI 889
Cdd:PRK12316  833 NLACYILDANLEPVPVGVLGELYLAGRGLARGYHGRPGLTAERFVPSPFVAGERMYRTGDLARYRADGVIEYAGRIDHQV 912

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  890 KIRGYRVEIGEVENALSILTNVESAVVIAEpinNSHRLLGYCVVKDIELDekTSEQLSQqylsQLRQNLPEYMVPSALTV 969
Cdd:PRK12316  913 KLRGLRIELGEIEARLLEHPWVREAAVLAV---DGKQLVGYVVLESEGGD--WREALKA----HLAASLPEYMVPAQWLA 983

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  970 MSEFPRNVSGKVDKKALPKPQIRAHSRMAETPE---QQLLCQITASVLKLDAIGIDDDFFMTGGDSISAIMLCTQLRQRG 1046
Cdd:PRK12316  984 LERLPLTPNGKLDRKALPAPEASVAQQGYVAPRnalERTLAAIWQDVLGVERVGLDDNFFELGGDSIVSIQVVSRARQAG 1063

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1047 YSLRPSDVFQFKTVAAMAPQLTRldEQQAAVSKplfsadleqkvqekyGKNSTILPLLPLQKgMLFLSQVENQSNYNAFT 1126
Cdd:PRK12316 1064 IQLSPRDLFQHQTIRSLALVAKA--GQATAADQ---------------GPASGEVALAPVQR-WFFEQAIPQRQHWNQSL 1125

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1127 RLSLNGDIDPVRLQQALITVLKRHPQLGGHFDSELAE------EPVFIYSLhptqaWPVQFCSVTPdlLEQTIQEAlQQP 1200
Cdd:PRK12316 1126 LLQARQPLDPDRLGRALERLVAHHDALRLRFREEDGGwqqayaAPQAGEVL-----WQRQAASEEE--LLALCEEA-QRS 1197

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1201 IHLDQ-PygLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYQQTNQQLPVLEHSYETVIKALSGrdHETSK 1279
Cdd:PRK12316 1198 LDLEQgP--LLRALLVDMADGSQRLLLVIHHLVVDGVSWRILLEDLQRAYADLDADLPARTSSYQAWARRLHE--HAGAR 1273

                        1210      1220      1230      1240
                  ....*....|....*....|....*....|....*....|....*..
gi 490930577 1280 V----IWQRDLADLQPLILFNQAQQAVQ-----ETSYRLSAELGAKL 1317
Cdd:PRK12316 1274 AeeldYWQAQLEDAPHELPCENPDGALEnrherKLELRLDAERTRQL 1320

PRK12467

peptide synthase; Provisional

152-1324

2.96e-134

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 473.49 E-value: 2.96e-134

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  152 HHIMLDGFSMINLTKRIVELYQQLQEGKDLSVS--PFIGVNEVISERQAYENSHQFKiDQAFWKAYC----------EDL 219
Cdd:PRK12467 1247 HHIVSDGWSMQVLVDELVALYAAYSQGQSLQLPalPIQYADYAVWQRQWMDAGERAR-QLAYWKAQLggeqpvlelpTDR 1325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  220 PSPISLSthHLAAKttatfvkHQLRFSTGILEQIQALAAQTKLALNDMMMSLSLHYIYKMTDKAELVNGIPFMRRLGSKA 299
Cdd:PRK12467 1326 PRPAVQS--HRGAR-------LAFELPPALAEGLRALARREGVTLFMLLLASFQTLLHRYSGQDDIRVGVPIANRNRAET 1396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  300 IRSTLPTVNVLPVKFKVAEKDSWVSLAQHVQEQLREIRPHQKYDAEQILRDLNSidihERMYG--PILNYkAFDQDLVID 377
Cdd:PRK12467 1397 EGLIGFFVNTQVLRAEVDGQASFQQLLQQVKQAALEAQAHQDLPFEQLVEALQP----ERSLShsPLFQV-MFNHQRDDH 1471

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  378 GEKVKTHHIStgpIDDFEFSFIVQDHELIIELRADSQ------RYTQDeLFNHG--QRLTL----LLEQALIRPEQPCSN 445
Cdd:PRK12467 1472 QAQAQLPGLS---VESLSWESQTAQFDLTLDTYESSEglqaslTYATD-LFEAStiERLAGhwlnLLQGLVADPERRLGE 1547

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  446 FNITTPQELTALTQSGIGPRVSHPEQyNNVLDIFYEQVKKYPERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGAR 525
Cdd:PRK12467 1548 LDLLDEAERRQILEGWNATHTGYPLA-RLVHQLIEDQAAATPEAVALVFGE----QELTYGELNRRANRLAHRLIALGVG 1622

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  526 KQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRMQMMCEDANPLFVLTTQALAQQLP--QNIQQLHLDQEgvQ 603
Cdd:PRK12467 1623 PEVLVGIAVERSLEMVVGLLAILKAGGAYVPLDPEYPRERLAYMIEDSGIELLLTQSHLQARLPlpDGLRSLVLDQE--D 1700

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  604 TQIRKQDASDiPAENrkFDFQDVAYVIFTSGSTGRPKGVMNTHGSLLNLilshkptiywpvLEAVNERFPdrpLRAA--- 680
Cdd:PRK12467 1701 DWLEGYSDSN-PAVN--LAPQNLAYVIYTSGSTGRPKGAGNRHGALVNR------------LCATQEAYQ---LSAAdvv 1762

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  681 -HTHSFSFDSSWLQVFW-MLWGQELHIFDENMRRDAFGLVQEIQQRQIDTLDLPPSFCAQMMTNGLFVENQHHPSLILIG 758
Cdd:PRK12467 1763 lQFTSFAFDVSVWELFWpLINGARLVIAPPGAHRDPEQLIQLIERQQVTTLHFVPSMLQQLLQMDEQVEHPLSLRRVVCG 1842

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  759 GEAAPLALWQQLNAQ-PALFAHNLYGPTEYTVDTF-----RAELKQTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELY 832
Cdd:PRK12467 1843 GEALEVEALRPWLERlPDTGLFNLYGPTETAVDVThwtcrRKDLEGRDSVPIGQPIANLSTYILDASLNPVPIGVAGELY 1922

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  833 ISGFGIANGYLGRADLSAARFVANPF-EHGQRMYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNV 911
Cdd:PRK12467 1923 LGGVGLARGYLNRPALTAERFVADPFgTVGSRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIEARLREQGGV 2002

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  912 ESAVVIAEPINNSHRLLGYCVVKDIEL-DEKTSEQLSQQYLSQ-LRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALPKP 989
Cdd:PRK12467 2003 REAVVIAQDGANGKQLVAYVVPTDPGLvDDDEAQVALRAILKNhLKASLPEYMVPAHLVFLARMPLTPNGKLDRKALPAP 2082

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  990 QIRAHSRMAETPE---QQLLCQITASVLKLDAIGIDDDFFMTGGDSISAIMLCTQLRQRGYSLRPSDVFQFKTVAAMApq 1066
Cdd:PRK12467 2083 DASELQQAYVAPQselEQRLAAIWQDVLGLEQVGLHDNFFELGGDSIISIQVVSRARQAGIRFTPKDLFQHQTVQSLA-- 2160

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1067 lTRLDEQQAAVSkplfsadLEQkvqekyGKNSTILPLLPLQKgMLFLSQVENQSNYNAFTRLSLNGDIDPVRLQQALITV 1146
Cdd:PRK12467 2161 -AVAQEGDGTVS-------IDQ------GPVTGDLPLLPIQQ-MFFADDIPERHHWNQSVLLEPREALDAELLEAALQAL 2225

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1147 LKRHPQL------------GGHFDSELAEEPVFiyslhptqaWPVQFCSVtpDLLEQTIQEALQQpihLDQPYG-LIRAT 1213
Cdd:PRK12467 2226 LVHHDALrlgfvqedggwsAMHRAPEQERRPLL---------WQVVVADK--EELEALCEQAQRS---LDLEEGpLLRAV 2291

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1214 LIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYQQTNQQLPVLEHSYETVIKALSGR--DHETSKVI------WQRD 1285
Cdd:PRK12467 2292 LATLPDGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQLQGGQPVKLPAKTSAFKAWAERlqTYAASAALadelgyWQAQ 2371

                        1210      1220      1230      1240
                  ....*....|....*....|....*....|....*....|.
gi 490930577 1286 LADLQPLILFNQAQQAVQeTSYRLSA--ELGAKLQHKLRQQ 1324
Cdd:PRK12467 2372 LQGASTELPCDHPQGGLQ-RRHAASVttHLDSEWTRRLLQE 2411

A_NRPS_CmdD_like

cd17652

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ...

1546-2032

1.46e-133

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).

Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 426.28 E-value: 1.46e-133

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1546 PEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFML 1625
Cdd:cd17652     1 PDAPAVVFGDETLTYAELNARANRLARLLAARGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAYML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1626 QDAKSKLVigeqkdlaaivhpsiatfafnelfdetkvdlssykttVITPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRIL 1705
Cdd:cd17652    81 ADARPALL-------------------------------------LTTPDNLAYVIYTSGSTGRPKGVVVTHRGLANLAA 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1706 WMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSMLAVFENAAt 1785
Cdd:cd17652   124 AQIAAFDVGPGSRVLQFASPSFDASVWELLMALLAGATLVLAPAEELLPGEPLADLLREHRITHVTLPPAALAALPPDD- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1786 eilssaqrqsLPICRVFCS-GEALPTALAKSFTEHfsCELHNLYGPTEAAVDVSYMDATlglhPEESCVAIGYPVWNTQL 1864
Cdd:cd17652   203 ----------LPDLRTLVVaGEACPAELVDRWAPG--RRMINAYGPTETTVCATMAGPL----PGGGVPPIGRPVPGTRV 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1865 YILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPF-TAGQRMYRTGDIARWHADGSIQYIGRADDQLKIR 1943
Cdd:cd17652   267 YVLDARLRPVPPGVPGELYIAGAGLARGYLNRPGLTAERFVADPFgAPGSRMYRTGDLARWRADGQLEFLGRADDQVKIR 346

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1944 GQRIELGEIEQQLRLISGLDVVVhAISSEQNKANVQLVAYL--QTTAPVDIDQLKKQLAKHLPAYMVPTHYMLVEQFPLS 2021
Cdd:cd17652   347 GFRIELGEVEAALTEHPGVAEAV-VVVRDDRPGDKRLVAYVvpAPGAAPTAAELRAHLAERLPGYMVPAAFVVLDALPLT 425

                         490
                  ....*....|.
gi 490930577 2022 HNGKLDRKALP 2032
Cdd:cd17652   426 PNGKLDRRALP 436

A_NRPS_Srf_like

cd12117

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ...

477-986

5.68e-132

Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 423.54 E-value: 5.68e-132

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  477 DIFYEQVKKYPERTAIVSGERpnlqHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLP 556
Cdd:cd12117     1 ELFEEQAARTPDAVAVVYGDR----SLTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  557 LDLDYPIDRMQMMCEDANPLFVLTTQALAQQLPQniqqlhldQEGVQTQIRKQDASDIPAENRKFDFQDVAYVIFTSGST 636
Cdd:cd12117    77 LDPELPAERLAFMLADAGAKVLLTDRSLAGRAGG--------LEVAVVIDEALDAGPAGNPAVPVSPDDLAYVMYTSGST 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  637 GRPKGVMNTHGSLLNLILSHkptiyWPVLEAVNERFpdrplraAHTHSFSFDSSWLQVFW-MLWGQELHIFDENMRRDAF 715
Cdd:cd12117   149 GRPKGVAVTHRGVVRLVKNT-----NYVTLGPDDRV-------LQTSPLAFDASTFEIWGaLLNGARLVLAPKGTLLDPD 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  716 GLVQEIQQRQIDTLdlppsfcaqMMTNGLFveNQ---HHPSL------ILIGGEAAPLALWQQ-LNAQPALFAHNLYGPT 785
Cdd:cd12117   217 ALGALIAEEGVTVL---------WLTAALF--NQladEDPECfaglreLLTGGEVVSPPHVRRvLAACPGLRLVNGYGPT 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  786 EYTVDT--FR-AELKQTARPV-IGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHG 861
Cdd:cd12117   286 ENTTFTtsHVvTELDEVAGSIpIGRPIANTRVYVLDEDGRPVPPGVPGELYVGGDGLALGYLNRPALTAERFVADPFGPG 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  862 QRMYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINN-SHRLLGYcVVKDIELDe 940
Cdd:cd12117   366 ERLYRTGDLARWLPDGRLEFLGRIDDQVKIRGFRIELGEIEAALRAHPGVREAVVVVREDAGgDKRLVAY-VVAEGALD- 443

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 490930577  941 ktSEQLSqqylSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKAL 986
Cdd:cd12117   444 --AAELR----AFLRERLPAYMVPAAFVVLDELPLTANGKVDRRAL 483

A_NRPS_AB3403-like

cd17646

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...

477-986

4.30e-131

Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 421.30 E-value: 4.30e-131

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  477 DIFYEQVKKYPERTAIVSGERpnlqHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLP 556
Cdd:cd17646     2 ALVAEQAARTPDAPAVVDEGR----TLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  557 LDLDYPIDRMQMMCEDANPLFVLTTQALAQQLPQniqqLHLDQEGVQTQIRKQDASDIPAENRKfdfQDVAYVIFTSGST 636
Cdd:cd17646    78 LDPGYPADRLAYMLADAGPAVVLTTADLAARLPA----GGDVALLGDEALAAPPATPPLVPPRP---DNLAYVIYTSGST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  637 GRPKGVMNTHGSLLNLILshkptiyWpvleaVNERFP----DRPLRAAhthSFSFDSSWLQVFW-MLWGQELHIFDENMR 711
Cdd:cd17646   151 GRPKGVMVTHAGIVNRLL-------W-----MQDEYPlgpgDRVLQKT---PLSFDVSVWELFWpLVAGARLVVARPGGH 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  712 RDAFGLVQEIQQRQIDTLDLPPSfcaqMMtnGLFVEN---QHHPSL--ILIGGEAAPLALWQQLNAQPALFAHNLYGPTE 786
Cdd:cd17646   216 RDPAYLAALIREHGVTTCHFVPS----ML--RVFLAEpaaGSCASLrrVFCSGEALPPELAARFLALPGAELHNLYGPTE 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  787 YTVDT--FRAELKQTARPV-IGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQR 863
Cdd:cd17646   290 AAIDVthWPVRGPAETPSVpIGRPVPNTRLYVLDDALRPVPVGVPGELYLGGVQLARGYLGRPALTAERFVPDPFGPGSR 369

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  864 MYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSH-RLLGYCVVKDIELDEKT 942
Cdd:cd17646   370 MYRTGDLARWRPDGALEFLGRSDDQVKIRGFRVEPGEIEAALAAHPAVTHAVVVARAAPAGAaRLVGYVVPAAGAAGPDT 449

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 490930577  943 SEqlsqqYLSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKAL 986
Cdd:cd17646   450 AA-----LRAHLAERLPEYMVPAAFVVLDALPLTANGKLDRAAL 488

PRK05691

peptide synthase; Validated

1100-2117

4.97e-130

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 460.02 E-value: 4.97e-130

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1100 ILPLLPLQKGMLFLSQVENQSN-YNAFTRLSLNGDIDPVRLQQALITVLKRHPQLGGHFDSELAEEPVFIysLHPTQAWP 1178
Cdd:PRK05691 3257 VYPLTPMQEGLLLHTLLEPGTGlYYMQDRYRINSALDPERFAQAWQAVVARHEALRASFSWNAGETMLQV--IHKPGRTP 3334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1179 VQFC---SVTPDLLEQTIQEALQQPIH-----LDQPYGLIRatLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYQ 1250
Cdd:PRK05691 3335 IDYLdwrGLPEDGQEQRLQALHKQEREagfdlLNQPPFHLR--LIRVDEARYWFMMSNHHILIDAWCRSLLMNDFFEIYT 3412

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1251 Q----TNQQLPVLEHsYETVIKALSGRDHETSKVIWQRDLADLQ---------PLI---LFNQAQQAVQETSYRLSAELG 1314
Cdd:PRK05691 3413 AlgegREAQLPVPPR-YRDYIGWLQRQDLAQARQWWQDNLRGFErptpipsdrPFLrehAGDSGGMVVGDCYTRLDAADG 3491

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1315 AKLQHKLRQQGITLNVFMQMIWAMTLNIYAHREDIVFGTPVSGRSAPINGLEQQIGLFLNTIPVRVKL---NMQQTLWEQ 1391
Cdd:PRK05691 3492 ARLRELAQAHQLTVNTFAQAAWALVLRRYSGDRDVLFGVTVAGRPVSMPQMQRTVGLFINSIALRVQLpaaGQRCSVRQW 3571

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1392 LPQLQQLHVEHLEHDGLGLSAIQQL--IAQGN-LFDSLLVVENYP-DNQYLQQKLGDAAISKlTNRGYSHYPLALLVIP- 1466
Cdd:PRK05691 3572 LQGLLDSNMELREYEYLPLVAIQECseLPKGQpLFDSLFVFENAPvEVSVLDRAQSLNASSD-SGRTHTNFPLTAVCYPg 3650

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1467 -DHQIELLLEQRgVIDQPEhfLERMI---QLIEIALNEP-ETSLSHYRLQLAEEHD-LIQKTNQTQ--YYVRQSTLQqLL 1538
Cdd:PRK05691 3651 dDLGLHLSYDQR-YFDAPT--VERLLgefKRLLLALVQGfHGDLSELPLLGEQERDfLLDGCNRSErdYPLEQSYVR-LF 3726

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1539 REQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPT 1618
Cdd:PRK05691 3727 EAQVAAHPQRIAASCLDQQWSYAELNRAANRLGHALRAAGVGVDQPVALLAERGLDLLGMIVGSFKAGAGYLPLDPGLPA 3806

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1619 ERIKFMLQDAKSKLVI--GEQKDLAAIVHPSIATFAFNEL--FDETKVDLSSYKTTVI--TPQHPAYLIYTSGTTGQPKG 1692
Cdd:PRK05691 3807 QRLQRIIELSRTPVLVcsAACREQARALLDELGCANRPRLlvWEEVQAGEVASHNPGIysGPDNLAYVIYTSGSTGLPKG 3886

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1693 VMVSHQAIVNRILwmqSEYP---LSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTT 1769
Cdd:PRK05691 3887 VMVEQRGMLNNQL---SKVPylaLSEADVIAQTASQSFDISVWQFLAAPLFGARVEIVPNAIAHDPQGLLAHVQAQGITV 3963

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1770 LHFVPSMLavfenaaTEILSSaQRQSLPICR-VFCSGEALPTALAKSFTEHF-SCELHNLYGPTEAAVDVSY----MDAT 1843
Cdd:PRK05691 3964 LESVPSLI-------QGMLAE-DRQALDGLRwMLPTGEAMPPELARQWLQRYpQIGLVNAYGPAECSDDVAFfrvdLAST 4035

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1844 LGlhpeeSCVAIGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTA-GQRMYRTGDIA 1922
Cdd:PRK05691 4036 RG-----SYLPIGSPTDNNRLYLLDEALELVPLGAVGELCVAGTGVGRGYVGDPLRTALAFVPHPFGApGERLYRTGDLA 4110

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1923 RWHADGSIQYIGRADDQLKIRGQRIELGEIEQQLRLISGL-DVVVHAISSEQNKanvQLVAYLQTTAPVD-----IDQLK 1996
Cdd:PRK05691 4111 RRRSDGVLEYVGRIDHQVKIRGYRIELGEIEARLHEQAEVrEAAVAVQEGVNGK---HLVGYLVPHQTVLaqgalLERIK 4187

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1997 KQLAKHLPAYMVPTHYMLVEQFPLSHNGKLDRKALPQPHLTPSNTEKQYA-TSAFEHELTRIFQQILNTDQnIGVNEDFF 2075
Cdd:PRK05691 4188 QRLRAELPDYMVPLHWLWLDRLPLNANGKLDRKALPALDIGQLQSQAYLApRNELEQTLATIWADVLKVER-VGVHDNFF 4266

                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|..
gi 490930577 2076 AIGGHSILVMKLAIEIRKVFKRTIPIGQLMSHVTIQRLAALL 2117
Cdd:PRK05691 4267 ELGGHSLLATQIASRVQKALQRNVPLRAMFECSTVEELAEYI 4308

A_NRPS_PvdJ-like

cd17649

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ...

1546-2032

3.51e-129

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes pyoverdine biosynthesis protein PvdJ involved in the synthesis of pyoverdine, which consists of a chromophore group attached to a variable peptide chain and comprises around 6-12 amino acids that are specific for each Pseudomonas species, and for which the peptide might be first synthesized before the chromophore assembly. Also included is ornibactin biosynthesis protein OrbI; ornibactin is a tetrapeptide siderophore with an l-ornithine-d-hydroxyaspartate-l-serine-l-ornithine backbone. The adenylation domain at the N-terminal of OrbI possibly initiates the ornibactin with the binding of N5-hydroxyornithine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 414.46 E-value: 3.51e-129

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1546 PEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFML 1625
Cdd:cd17649     1 PDAVALVFGDQSLSYAELDARANRLAHRLRALGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERLRYML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1626 QDAKSKLVIGEqkdlaaivhpsiatfafnelfdetkvdlssykttviTPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRIL 1705
Cdd:cd17649    81 EDSGAGLLLTH------------------------------------HPRQLAYVIYTSGSTGTPKGVAVSHGPLAAHCQ 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1706 WMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSMLAVFenaAT 1785
Cdd:cd17649   125 ATAERYGLTPGDRELQFASFNFDGAHEQLLPPLICGACVVLRPDELWASADELAEMVRELGVTVLDLPPAYLQQL---AE 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1786 EILSSAQRQSLPIcRVFCS-GEAL-PTALAKSFTEHfsCELHNLYGPTEAAVDVSYMDATLGLHPEESCVAIGYPVWNTQ 1863
Cdd:cd17649   202 EADRTGDGRPPSL-RLYIFgGEALsPELLRRWLKAP--VRLFNAYGPTEATVTPLVWKCEAGAARAGASMPIGRPLGGRS 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1864 LYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPF-TAGQRMYRTGDIARWHADGSIQYIGRADDQLKI 1942
Cdd:cd17649   279 AYILDADLNPVPVGVTGELYIGGEGLARGYLGRPELTAERFVPDPFgAPGSRLYRTGDLARWRDDGVIEYLGRVDHQVKI 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1943 RGQRIELGEIEQQLRLISG-LDVVVHAISSEQNKanvQLVAYL----QTTAPVDIDQLKKQLAKHLPAYMVPTHYMLVEQ 2017
Cdd:cd17649   359 RGFRIELGEIEAALLEHPGvREAAVVALDGAGGK---QLVAYVvlraAAAQPELRAQLRTALRASLPDYMVPAHLVFLAR 435

                         490
                  ....*....|....*
gi 490930577 2018 FPLSHNGKLDRKALP 2032
Cdd:cd17649   436 LPLTPNGKLDRKALP 450

A_NRPS_VisG_like

cd17651

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ...

479-987

1.97e-128

Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 413.66 E-value: 1.97e-128

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  479 FYEQVKKYPERTAIVSGERpnlqHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLD 558
Cdd:cd17651     1 FERQAARTPDAPALVAEGR----RLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  559 LDYPIDRMQMMCEDANPLFVLTTQALAQQLPQniqqlhlDQEGVQTQIRKQDASDIPAENR-KFDFQDVAYVIFTSGSTG 637
Cdd:cd17651    77 PAYPAERLAFMLADAGPVLVLTHPALAGELAV-------ELVAVTLLDQPGAAAGADAEPDpALDADDLAYVIYTSGSTG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  638 RPKGVMNTHGSLLNLILSHkptiywpvleavNERFP-DRPLRAAHTHSFSFDSSWLQVFWML-WGQELHIFDENMRRDAF 715
Cdd:cd17651   150 RPKGVVMPHRSLANLVAWQ------------ARASSlGPGARTLQFAGLGFDVSVQEIFSTLcAGATLVLPPEEVRTDPP 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  716 GLVQEIQQRQIDTLDLPPSFcAQMMTNGLFVENQHHPSL--ILIGGEAAPL--ALWQQLNAQPALFAHNLYGPTEYTVDT 791
Cdd:cd17651   218 ALAAWLDEQRISRVFLPTVA-LRALAEHGRPLGVRLAALryLLTGGEQLVLteDLREFCAGLPGLRLHNHYGPTETHVVT 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  792 FRaELKQ-----TARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQRMYR 866
Cdd:cd17651   297 AL-SLPGdpaawPAPPPIGRPIDNTRVYVLDAALRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPDPFVPGARMYR 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  867 TGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEP-INNSHRLLGYcVVKDIELDEKTSEq 945
Cdd:cd17651   376 TGDLARWLPDGELEFLGRADDQVKIRGFRIELGEIEAALARHPGVREAVVLAREdRPGEKRLVAY-VVGDPEAPVDAAE- 453

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 490930577  946 LSQqylsQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALP 987
Cdd:cd17651   454 LRA----ALATHLPEYMVPSAFVLLDALPLTPNGKLDRRALP 491

A_NRPS_Ta1_like

cd12116

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ...

487-986

5.00e-128

Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 411.68 E-value: 5.00e-128

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  487 PERTAIVSGERPnlqhLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRM 566
Cdd:cd12116     1 PDATAVRDDDRS----LSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  567 QMMCEDANPLFVLTTQALAQQLPQNIQQLHLDQEGVQTQIRKQDASDIPAenrkfdfqDVAYVIFTSGSTGRPKGVMNTH 646
Cdd:cd12116    77 RYILEDAEPALVLTDDALPDRLPAGLPVLLLALAAAAAAPAAPRTPVSPD--------DLAYVIYTSGSTGRPKGVVVSH 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  647 GSLLNLilshkptiywpvLEAVNERF---PDRPLRAAHThsFSFDSSWLQVFWMLW-GQELHIFDENMRRDAFGLVQEIQ 722
Cdd:cd12116   149 RNLVNF------------LHSMRERLglgPGDRLLAVTT--YAFDISLLELLLPLLaGARVVIAPRETQRDPEALARLIE 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  723 QRQIDTLDLPPSfCAQMMtngLFVENQHHPSL-ILIGGEAAPLALWQQLNAQPALfAHNLYGPTEYTVDTFRAELKQTAR 801
Cdd:cd12116   215 AHSITVMQATPA-TWRML---LDAGWQGRAGLtALCGGEALPPDLAARLLSRVGS-LWNLYGPTETTIWSTAARVTAAAG 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  802 PV-IGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEH-GQRMYRTGDLVRWNSAGKL 879
Cdd:cd12116   290 PIpIGRPLANTQVYVLDAALRPVPPGVPGELYIGGDGVAQGYLGRPALTAERFVPDPFAGpGSRLYRTGDLVRRRADGRL 369

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  880 EFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSHRLLGYCVVKDIE-LDEktsEQLSQqylsQLRQNL 958
Cdd:cd12116   370 EYLGRADGQVKIRGHRIELGEIEAALAAHPGVAQAAVVVREDGGDRRLVAYVVLKAGAaPDA---AALRA----HLRATL 442

                         490       500
                  ....*....|....*....|....*...
gi 490930577  959 PEYMVPSALTVMSEFPRNVSGKVDKKAL 986
Cdd:cd12116   443 PAYMVPSAFVRLDALPLTANGKLDRKAL 470

A_NRPS_Sfm_like

cd12115

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ...

1534-2031

4.88e-127

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the saframycin A gene cluster from Streptomyces lavendulae which implicates the NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. It also includes saframycin Mx1 produced by Myxococcus xanthus NRPS.

Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 407.86 E-value: 4.88e-127

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1534 LQQLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPID 1613
Cdd:cd12115     1 LHDLVEAQAARTPDAIALVCGDESLTYAELNRRANRLAARLRAAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1614 LQHPTERIKFMLQDAKSKLVIgeqkdlaaivhpsiatfafnelfdetkvdlssykttvITPQHPAYLIYTSGTTGQPKGV 1693
Cdd:cd12115    81 PAYPPERLRFILEDAQARLVL-------------------------------------TDPDDLAYVIYTSGSTGRPKGV 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1694 MVSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIApidahRDPLALLSLIQKYQVTTLHFV 1773
Cdd:cd12115   124 AIEHRNAAAFLQWAAAAFSAEELAGVLASTSICFDLSVFELFGPLATGGKVVLA-----DNVLALPDLPAAAEVTLINTV 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1774 PSmlavfenAATEILS-SAQRQSLpicRVFC-SGEALPTALAKSFTEHFSCE-LHNLYGPTEaavDVSYMDAT-LGLHPE 1849
Cdd:cd12115   199 PS-------AAAELLRhDALPASV---RVVNlAGEPLPRDLVQRLYARLQVErVVNLYGPSE---DTTYSTVApVPPGAS 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1850 EScVAIGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADGS 1929
Cdd:cd12115   266 GE-VSIGRPLANTQAYVLDRALQPVPLGVPGELYIGGAGVARGYLGRPGLTAERFLPDPFGPGARLYRTGDLVRWRPDGL 344

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1930 IQYIGRADDQLKIRGQRIELGEIEQQLRLISGLD---VVVHaissEQNKANVQLVAYLQTTAP--VDIDQLKKQLAKHLP 2004
Cdd:cd12115   345 LEFLGRADNQVKVRGFRIELGEIEAALRSIPGVReavVVAI----GDAAGERRLVAYIVAEPGaaGLVEDLRRHLGTRLP 420

                         490       500
                  ....*....|....*....|....*..
gi 490930577 2005 AYMVPTHYMLVEQFPLSHNGKLDRKAL 2031
Cdd:cd12115   421 AYMVPSRFVRLDALPLTPNGKIDRSAL 447

PRK12316

peptide synthase; Provisional

152-1324

1.85e-126

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 448.64 E-value: 1.85e-126

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  152 HHIMLDGFSMINLTKRIVELYQQLQEGKDLSVSPF-IGVNEVISERQAYENSHQFKIDQAFWKAYCEDLPSPISLSTHHL 230
Cdd:PRK12316 2731 HHIVSDGWSMQVMVDELVQAYAGARRGEQPTLPPLpLQYADYAAWQRAWMDSGEGARQLDYWRERLGGEQPVLELPLDRP 2810

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  231 -AAKTTATFVKHQLRFSTGILEQIQALAAQTKLALNDMMMSLSLHYIYKMTDKAELVNGIPFMRRLGSKAIRSTLPTVNV 309
Cdd:PRK12316 2811 rPALQSHRGARLDVALDVALSRELLALARREGVTLFMLLLASFQVLLHRYSGQSDIRVGVPIANRNRAETERLIGFFVNT 2890

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  310 LPVKFKVAEKDSWVSLAQHVQEQLREIRPHQKYDAEQIL------RDLNSIDIHERMYGPILNYKAFDQDLVIDGEKVKT 383
Cdd:PRK12316 2891 QVLRAQVDAQLAFRDLLGQVKEQALGAQAHQDLPFEQLVealqpeRSLSHSPLFQVMYNHQSGERAAAQLPGLHIESFAW 2970

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  384 HHISTGPidDFEFSFIVQDHELIIELRADSQRYTQDELFNHGQRLTLLLEQALIRPEQPCSNFNITTPQELTALTQSGIG 463
Cdd:PRK12316 2971 DGAATQF--DLALDTWESAEGLGASLTYATDLFDARTVERLARHWQNLLRGMVENPQRSVDELAMLDAEERGQLLEAWNA 3048

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  464 PRVSHPEQyNNVLDIFYEQVKKYPERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVV 543
Cdd:PRK12316 3049 TAAEYPLE-RGVHRLFEEQVERTPDAVALAFGE----QRLSYAELNRRANRLAHRLIERGVGPDVLVGVAVERSLEMVVG 3123

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  544 MLSVLNSGASFLPLDLDYPIDRMQMMCEDANPLFVLTTQALAQQLPQNIQQLHLDQEGVQTQIRKQDASDIPaenrkfdf 623
Cdd:PRK12316 3124 LLAILKAGGAYVPLDPEYPEERLAYMLEDSGAQLLLSQSHLRLPLAQGVQVLDLDRGDENYAEANPAIRTMP-------- 3195

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  624 QDVAYVIFTSGSTGRPKGVMNTHGSLLNLILShkptiywpVLEAVNERFPDRPLRAAhthSFSFDSSWLQVFWMLW-GQE 702
Cdd:PRK12316 3196 ENLAYVIYTSGSTGKPKGVGIRHSALSNHLCW--------MQQAYGLGVGDRVLQFT---TFSFDVFVEELFWPLMsGAR 3264

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  703 LHIFDENMRRDAFGLVQEIQQRQIDTLDLPPSFCAQMMTNglfVENQHHPSL--ILIGGEAAPLALWQQLNAQPALFahN 780
Cdd:PRK12316 3265 VVLAGPEDWRDPALLVELINSEGVDVLHAYPSMLQAFLEE---EDAHRCTSLkrIVCGGEALPADLQQQVFAGLPLY--N 3339

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  781 LYGPTEYTVDT--FRAELKQTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPF 858
Cdd:PRK12316 3340 LYGPTEATITVthWQCVEEGKDAVPIGRPIANRACYILDGSLEPVPVGALGELYLGGEGLARGYHNRPGLTAERFVPDPF 3419

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  859 EHGQRMYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEpinNSHRLLGYCVVKDIEL 938
Cdd:PRK12316 3420 VPGERLYRTGDLARYRADGVIEYIGRVDHQVKIRGFRIELGEIEARLLEHPWVREAVVLAV---DGRQLVAYVVPEDEAG 3496

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  939 DektseqLSQQYLSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALPKP---QIRAHSRMAETPEQQLLCQITASVLK 1015
Cdd:PRK12316 3497 D------LREALKAHLKASLPEYMVPAHLLFLERMPLTPNGKLDRKALPRPdaaLLQQDYVAPVNELERRLAAIWADVLK 3570

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1016 LDAIGIDDDFFMTGGDSISAIMLCTQLRQRGYSLRPSDVFQFKTVAAMAPqLTRLDEQQAAVSKPLfsadleqkvqekyg 1095
Cdd:PRK12316 3571 LEQVGLTDNFFELGGDSIISLQVVSRARQAGIRFTPKDLFQHQTIQGLAR-VARVGGGVAVDQGPV-------------- 3635

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1096 knSTILPLLPLQKGmLFLSQVENQSNYNAFTRLSLNGDIDPVRLQQALITVLKRHPQLGGHFDSELAEEPVFIYSLHPTQ 1175
Cdd:PRK12316 3636 --SGETLLLPIQQQ-FFEEPVPERHHWNQSLLLKPREALDAAALEAALQALVEHHDALRLRFVEDAGGWTAEHLPVELGG 3712

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1176 AWPVQFCSVTPDLLEQTIQEAlQQPIHL-DQPygLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYQQTNQ 1254
Cdd:PRK12316 3713 ALLWRAELDDAEELERLGEEA-QRSLDLaDGP--LLRALLATLADGSQRLLLVIHHLVVDGVSWRILLEDLQQAYQQLLQ 3789

                        1130      1140      1150      1160      1170      1180      1190
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490930577 1255 ----QLPVLEHSYETVIKALSGRDHETSK----VIWQRDLADLQPLILFNQAQQAVQETSYR-LSAELGAKLQHKLRQQ 1324
Cdd:PRK12316 3790 geapRLPAKTSSFKAWAERLQEHARGEALkaelAYWQEQLQGVSSELPCDHPQGALQNRHAAsVQTRLDRELTRRLLQQ 3868

A_NRPS_Bac

cd17655

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ...

479-989

2.37e-126

Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 407.87 E-value: 2.37e-126

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  479 FYEQVKKYPERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLD 558
Cdd:cd17655     3 FEEQAEKTPDHTAVVFED----QTLTYRELNERANQLARTLREKGVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPID 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  559 LDYPIDRMQMMCEDANPLFVLTTQALAQQLpQNIQQLHLDQEGvqtQIRKQDASDIPAENRkfdFQDVAYVIFTSGSTGR 638
Cdd:cd17655    79 PDYPEERIQYILEDSGADILLTQSHLQPPI-AFIGLIDLLDED---TIYHEESENLEPVSK---SDDLAYVIYTSGSTGK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  639 PKGVMNTHGSLLNLILSHKPTIYwpvleavnerfPDRPLRAAHTHSFSFDSSWLQVFW-MLWGQELHIFDENMRRDAFGL 717
Cdd:cd17655   152 PKGVMIEHRGVVNLVEWANKVIY-----------QGEHLRVALFASISFDASVTEIFAsLLSGNTLYIVRKETVLDGQAL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  718 VQEIQQRQIDTLDLPPSFCAQMMTNGLFVE-NQHHpslILIGGEAAPLALWQQL----NAQPALFahNLYGPTEYTVDT- 791
Cdd:cd17655   221 TQYIRQNRITIIDLTPAHLKLLDAADDSEGlSLKH---LIVGGEALSTELAKKIielfGTNPTIT--NAYGPTETTVDAs 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  792 ---FRAELKQTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQRMYRTG 868
Cdd:cd17655   296 iyqYEPETDQQVSVPIGKPLGNTRIYILDQYGRPQPVGVAGELYIGGEGVARGYLNRPELTAEKFVDDPFVPGERMYRTG 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  869 DLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEP-INNSHRLLGYcVVKDIELdekTSEQLS 947
Cdd:cd17655   376 DLARWLPDGNIEFLGRIDHQVKIRGYRIELGEIEARLLQHPDIKEAVVIARKdEQGQNYLCAY-IVSEKEL---PVAQLR 451

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 490930577  948 QqylsQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALPKP 989
Cdd:cd17655   452 E----FLARELPDYMIPSYFIKLDEIPLTPNGKVDRKALPEP 489

PRK12316

peptide synthase; Provisional

53-1072

1.26e-122

peptide synthase; Provisional

Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 436.31 E-value: 1.26e-122

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   53 VDIPTFKKAIQIGLNEADTVIASY--SSDPSQPFIELNNQVQFQIEEFDFCHLTPKKAQqrLWDWMPSDRQCAKSLKagE 130
Cdd:PRK12316 4136 LDVERFRAAWQAALDRHDVLRSGFvwQGELGRPLQVVHKQVSLPFAELDWRGRADLQAA--LDALAAAERERGFDLQ--R 4211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  131 TQLFRQVLFTT----HDKVYwyqRYHHIMLDGFSMINLTKRIVELYQQLQEGK-DLSVSPFIGvnevISERQAYENShqf 205
Cdd:PRK12316 4212 APLLRLVLVRTaegrHHLIY---TNHHILMDGWSNSQLLGEVLERYSGRPPAQpGGRYRDYIA----WLQRQDAAAS--- 4281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  206 kidQAFWKAYCEDLPSPISLSTHHLAAK--TTATFVKHQLRFSTGILEQIQALAAQTKLALNDMMMSLSLHYIYKMTDKA 283
Cdd:PRK12316 4282 ---EAFWREQLAALDEPTRLAQAIARADlrSANGYGEHVRELDATATARLREFARTQRVTLNTLVQAAWLLLLQRYTGQD 4358

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  284 ELVNGIPFMRRLGS-KAIRSTLPT-VNVLPVKFKVAEKDSWVSLAQHVQEQLREIRPHQKYDAEQILRD--------LNS 353
Cdd:PRK12316 4359 TVAFGATVAGRPAElPGIEGQIGLfINTLPVIATPRAQQSVVEWLQQVQRQNLALREHEHTPLYEIQRWagqggealFDS 4438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  354 IDIHERMygPILNY--KAFDQDLVIDgeKVKTHHISTGPIDdfeFSFIVQDhELIIELRADSQRYTQDELFNHGQRLTLL 431
Cdd:PRK12316 4439 LLVFENY--PVSEAlqQGAPGGLRFG--EVTNHEQTNYPLT---LAVGLGE-TLSLQFSYDRGHFDAATIERLARHLTNL 4510

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  432 LEQALIRPEQPCSNFNITTPQELTALTQSGIGPRVSHPEQyNNVLDIFYEQVKKYPERTAIVSGErpnlQHLSFAELAVK 511
Cdd:PRK12316 4511 LEAMAEDPQRRLGELQLLEKAEQQRIVALWNRTDAGYPAT-RCVHQLVAERARMTPDAVAVVFDE----EKLTYAELNRR 4585

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  512 VNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRMQMMCEDANPLFVLTTQALAQQLP-- 589
Cdd:PRK12316 4586 ANRLAHALIARGVGPEVLVGIAMERSAEMMVGLLAVLKAGGAYVPLDPEYPRERLAYMMEDSGAALLLTQSHLLQRLPip 4665

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  590 QNIQQLHLDQEGvqtqirkqDASDIPAEN--RKFDFQDVAYVIFTSGSTGRPKGVMNTHGSLLNLILShkptiywpVLEA 667
Cdd:PRK12316 4666 DGLASLALDRDE--------DWEGFPAHDpaVRLHPDNLAYVIYTSGSTGRPKGVAVSHGSLVNHLHA--------TGER 4729

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  668 VNERFPDRPLraaHTHSFSFDSSWLQVFWMLW-GQELHIFDENMRrDAFGLVQEIQQRQIDTLDLPPSFCaQMMTNGlFV 746
Cdd:PRK12316 4730 YELTPDDRVL---QFMSFSFDGSHEGLYHPLInGASVVIRDDSLW-DPERLYAEIHEHRVTVLVFPPVYL-QQLAEH-AE 4803

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  747 ENQHHPSL--ILIGGEAAPLALWQQ-LNAQPALFAHNLYGPTEYTVDTfraeLKQTARPV---------IGNPIGNTQAY 814
Cdd:PRK12316 4804 RDGEPPSLrvYCFGGEAVAQASYDLaWRALKPVYLFNGYGPTETTVTV----LLWKARDGdacgaaympIGTPLGNRSGY 4879

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  815 VLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPF-EHGQRMYRTGDLVRWNSAGKLEFMGRCDDQIKIRG 893
Cdd:PRK12316 4880 VLDGQLNPLPVGVAGELYLGGEGVARGYLERPALTAERFVPDPFgAPGGRLYRTGDLARYRADGVIDYLGRVDHQVKIRG 4959

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  894 YRVEIGEVENALSILTNVESAVVIAEPINNSHRLLGYCVVKDIELDEKTSEQ--LSQQYLSQLRQNLPEYMVPSALTVMS 971
Cdd:PRK12316 4960 FRIELGEIEARLREHPAVREAVVIAQEGAVGKQLVGYVVPQDPALADADEAQaeLRDELKAALRERLPEYMVPAHLVFLA 5039

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  972 EFPRNVSGKVDKKALPKPQIRAHSRMAETPEQQLLCQITA---SVLKLDAIGIDDDFFMTGGDSISAIMLCTQLR-QRGY 1047
Cdd:PRK12316 5040 RMPLTPNGKLDRKALPQPDASLLQQAYVAPRSELEQQVAAiwaEVLQLERVGLDDNFFELGGHSLLAIQVTSRIQlELGL 5119

                        1050      1060
                  ....*....|....*....|....*
gi 490930577 1048 SLRPSDVFQFKTVAAMAPQLTRLDE 1072
Cdd:PRK12316 5120 ELPLRELFQTPTLAAFVELAAAAGS 5144

A_NRPS_CmdD_like

cd17652

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ...

487-987

2.03e-120

Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 388.53 E-value: 2.03e-120

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  487 PERTAIVSGERpnlqHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRM 566
Cdd:cd17652     1 PDAPAVVFGDE----TLTYAELNARANRLARLLAARGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  567 QMMCEDANPLFVLTTQAlaqqlpqniqqlhldqegvqtqirkqdasdipaenrkfdfqDVAYVIFTSGSTGRPKGVMNTH 646
Cdd:cd17652    77 AYMLADARPALLLTTPD-----------------------------------------NLAYVIYTSGSTGRPKGVVVTH 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  647 GSLLNLIlshkptiywpvlEAVNERFPDRP-LRAAHTHSFSFDSSwlqvFWMLW-----GQELHIFDENMRRDAFGLVQE 720
Cdd:cd17652   116 RGLANLA------------AAQIAAFDVGPgSRVLQFASPSFDAS----VWELLmallaGATLVLAPAEELLPGEPLADL 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  721 IQQRQIDTLDLPPSFCAQMMTNGLfvenqhhPSL--ILIGGEAAPLALWQQLNAQPALFahNLYGPTEYTVDTFRAELKQ 798
Cdd:cd17652   180 LREHRITHVTLPPAALAALPPDDL-------PDLrtLVVAGEACPAELVDRWAPGRRMI--NAYGPTETTVCATMAGPLP 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  799 TARPV-IGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPF-EHGQRMYRTGDLVRWNSA 876
Cdd:cd17652   251 GGGVPpIGRPVPGTRVYVLDARLRPVPPGVPGELYIAGAGLARGYLNRPGLTAERFVADPFgAPGSRMYRTGDLARWRAD 330

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  877 GKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSH-RLLGYCVVKDIELDekTSEQLSQqylsQLR 955
Cdd:cd17652   331 GQLEFLGRADDQVKIRGFRIELGEVEAALTEHPGVAEAVVVVRDDRPGDkRLVAYVVPAPGAAP--TAAELRA----HLA 404

                         490       500       510
                  ....*....|....*....|....*....|..
gi 490930577  956 QNLPEYMVPSALTVMSEFPRNVSGKVDKKALP 987
Cdd:cd17652   405 ERLPGYMVPAAFVVLDALPLTPNGKLDRRALP 436

A_NRPS_SidN3_like

cd05918

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ...

1534-2031

6.96e-120

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 388.82 E-value: 6.96e-120

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1534 LQQLLREQARITPEQTALSDENHQLSFSEvrLQVCA--LAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLP 1611
Cdd:cd05918     1 VHDLIEERARSQPDAPAVCAWDGSLTYAE--LDRLSsrLAHHLRSLGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1612 IDLQHPTERIKFMLQDAKSKLVigeqkdlaaivhpsiatfafnelfdetkvdLSSykttviTPQHPAYLIYTSGTTGQPK 1691
Cdd:cd05918    79 LDPSHPLQRLQEILQDTGAKVV------------------------------LTS------SPSDAAYVIFTSGSTGKPK 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1692 GVMVSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLAllSLIQKYQVTTLH 1771
Cdd:cd05918   123 GVVIEHRALSTSALAHGRALGLTSESRVLQFASYTFDVSILEIFTTLAAGGCLCIPSEEDRLNDLA--GFINRLRVTWAF 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1772 FVPSMLAVFenaateilssaQRQSLPICRVFCS-GEALPTALAKSFTEHfsCELHNLYGPTEAAVDVSYMDATLGLHPEE 1850
Cdd:cd05918   201 LTPSVARLL-----------DPEDVPSLRTLVLgGEALTQSDVDTWADR--VRLINAYGPAECTIAATVSPVVPSTDPRN 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1851 scvaIGYPVwNTQLYILDQ--YLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANP-------FTAGQRMYRTGDI 1921
Cdd:cd05918   268 ----IGRPL-GATCWVVDPdnHDRLVPIGAVGELLIEGPILARGYLNDPEKTAAAFIEDPawlkqegSGRGRRLYRTGDL 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1922 ARWHADGSIQYIGRADDQLKIRGQRIELGEIEQQLRLI--SGLDVVVHAISSEQNKANVQLVAYLQT------------- 1986
Cdd:cd05918   343 VRYNPDGSLEYVGRKDTQVKIRGQRVELGEIEHHLRQSlpGAKEVVVEVVKPKDGSSSPQLVAFVVLdgsssgsgdgdsl 422

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 490930577 1987 ------TAPVDIDQLKKQLAKHLPAYMVPTHYMLVEQFPLSHNGKLDRKAL 2031
Cdd:cd05918   423 flepsdEFRALVAELRSKLRQRLPSYMVPSVFLPLSHLPLTASGKIDRRAL 473

A_NRPS_PpsD_like

cd17650

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ...

1546-2031

2.65e-119

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 385.67 E-value: 2.65e-119

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1546 PEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFML 1625
Cdd:cd17650     1 PDAIAVSDATRQLTYRELNERANQLARTLRGLGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1626 QDAKSKLVigeqkdlaaivhpsiatfafnelfdetkvdlssykttVITPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRIL 1705
Cdd:cd17650    81 EDSGAKLL-------------------------------------LTQPEDLAYVIYTSGTTGKPKGVMVEHRNVAHAAH 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1706 WMQSEYPLSA-TDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSML-AVFENA 1783
Cdd:cd17650   124 AWRREYELDSfPVRLLQMASFSFDVFAGDFARSLLNGGTLVICPDEVKLDPAALYDLILKSRITLMESTPALIrPVMAYV 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1784 ATEILSSAQRQSLPICRVFCSGEALPTALAKsFTEHFscELHNLYGPTEAAVDVSYMDATLGLHPEESCVAIGYPVWNTQ 1863
Cdd:cd17650   204 YRNGLDLSAMRLLIVGSDGCKAQDFKTLAAR-FGQGM--RIINSYGVTEATIDSTYYEEGRDPLGDSANVPIGRPLPNTA 280

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1864 LYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADGSIQYIGRADDQLKIR 1943
Cdd:cd17650   281 MYVLDERLQPQPVGVAGELYIGGAGVARGYLNRPELTAERFVENPFAPGERMYRTGDLARWRADGNVELLGRVDHQVKIR 360

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1944 GQRIELGEIEQQLRLISGLDVVVHAIsSEQNKANVQLVAYLQTTAPVDIDQLKKQLAKHLPAYMVPTHYMLVEQFPLSHN 2023
Cdd:cd17650   361 GFRIELGEIESQLARHPAIDEAVVAV-REDKGGEARLCAYVVAAATLNTAELRAFLAKELPSYMIPSYYVQLDALPLTPN 439


                  ....*...
gi 490930577 2024 GKLDRKAL 2031
Cdd:cd17650   440 GKVDRRAL 447

PRK12467

peptide synthase; Provisional

54-1064

1.29e-116

peptide synthase; Provisional

Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 416.48 E-value: 1.29e-116

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   54 DIPTFKKAIQIGLNEADTVIASYSSDP--SQPFIELNNQVQFQIEEFDFchLTPKKAQQRLWDWMPSDRQcaKSLKAGET 131
Cdd:PRK12467 2681 DVERFRTAWQAVIDRHEILRSGFLWDGelEEPLQVVYKQARLPFSRLDW--RDRADLEQALDALAAADRQ--QGFDLLSA 2756

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  132 QLFRQVLFTT-HDKVYWYQRYHHIMLDGFSMINLTKRIVELYQqlqeGKDLSvSPFIGVNEVISERQAYENSHQfkidQA 210
Cdd:PRK12467 2757 PLLRLTLVRTgEDRHHLIYTNHHILMDGWSGSQLLGEVLQRYF----GQPPP-AREGRYRDYIAWLQAQDAEAS----EA 2827

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  211 FWKAYCEDLPSPISL--STHHLAAKTTATFVKHQLRFSTGILEQIQALAAQTKLALNDMMMSLSLHYIYKMTDKAELVNG 288
Cdd:PRK12467 2828 FWKEQLAALEEPTRLarALYPAPAEAVAGHGAHYLHLDATQTRQLIEFARRHRVTLNTLVQGAWLLLLQRFTGQDTVCFG 2907

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  289 ipfmrrlgskAIRSTLPT------------VNVLPVkfkVAEKDSWVSLA---QHVQEQLREIRPHQKYDAEQILR---- 349
Cdd:PRK12467 2908 ----------ATVAGRPAqlrgaeqqlglfINTLPV---IASPRAEQTVSdwlQQVQAQNLALREFEHTPLADIQRwagq 2974

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  350 ----DLNSIDIHErmygpilNY-------KAFDQDLVIdgEKVKTHHISTGPIDdfefSFIVQDHELIIELRADSQRYTQ 418
Cdd:PRK12467 2975 ggeaLFDSILVFE-------NYpisealkQGAPSGLRF--GAVSSREQTNYPLT----LAVGLGDTLELEFSYDRQHFDA 3041

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  419 DELFNHGQRLTLLLEQALIRPEQPCSNFNITTPQELTALTQSGIGPRVSHPEQyNNVLDIFYEQVKKYPERTAIVSGErp 498
Cdd:PRK12467 3042 AAIERLAESFDRLLQAMLNNPAARLGELPTLAAHERRQVLHAWNATAAAYPSE-RLVHQLIEAQVARTPEAPALVFGD-- 3118

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  499 nlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRMQMMCEDANPLFV 578
Cdd:PRK12467 3119 --QQLSYAELNRRANRLAHRLIAIGVGPDVLVGVAVERSVEMIVALLAVLKAGGAYVPLDPEYPRERLAYMIEDSGVKLL 3196

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  579 LTTQALAQQLPQ--NIQQLHLDQEGVQTQIRKQDASDIPAENrkfdfqdVAYVIFTSGSTGRPKGVMNTHGSLLNLIlsh 656
Cdd:PRK12467 3197 LTQAHLLEQLPApaGDTALTLDRLDLNGYSENNPSTRVMGEN-------LAYVIYTSGSTGKPKGVGVRHGALANHL--- 3266

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  657 kptiYWpVLEAVNERFPDRPLRAAhthSFSFDSSWLQVFWMLW-GQELHIFDeNMRRDAFGLVQEIQQRQIDTLDLPPSF 735
Cdd:PRK12467 3267 ----CW-IAEAYELDANDRVLLFM---SFSFDGAQERFLWTLIcGGCLVVRD-NDLWDPEELWQAIHAHRISIACFPPAY 3337

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  736 CAQMMTNGlfvENQHHPSL--ILIGGEAAPLALWQQLNAQ-PALFAHNLYGPTEYTVDTFRAELKQTARPV-----IGNP 807
Cdd:PRK12467 3338 LQQFAEDA---GGADCASLdiYVFGGEAVPPAAFEQVKRKlKPRGLTNGYGPTEAVVTVTLWKCGGDAVCEapyapIGRP 3414

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  808 IGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFE-HGQRMYRTGDLVRWNSAGKLEFMGRCD 886
Cdd:PRK12467 3415 VAGRSIYVLDGQLNPVPVGVAGELYIGGVGLARGYHQRPSLTAERFVADPFSgSGGRLYRTGDLARYRADGVIEYLGRID 3494

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  887 DQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSHRLLGYcVVKDIEldektSEQLSQQYLSQLRQNLPEYMVPSA 966
Cdd:PRK12467 3495 HQVKIRGFRIELGEIEARLLQHPSVREAVVLARDGAGGKQLVAY-VVPADP-----QGDWRETLRDHLAASLPDYMVPAQ 3568

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  967 LTVMSEFPRNVSGKVDKKALPKPQI---RAHSRMAETPEQQlLCQITASVLKLDAIGIDDDFFMTGGDSISAIMLCTQLR 1043
Cdd:PRK12467 3569 LLVLAAMPLGPNGKVDRKALPDPDAkgsREYVAPRSEVEQQ-LAAIWADVLGVEQVGVTDNFFELGGDSLLALQVLSRIR 3647

                        1050      1060
                  ....*....|....*....|..
gi 490930577 1044 Q-RGYSLRPSDVFQFKTVAAMA 1064
Cdd:PRK12467 3648 QsLGLKLSLRDLMSAPTIAELA 3669

AA-adenyl-dom

amino acid adenylation domain; This model represents a domain responsible for the specific ...

504-916

8.48e-115

Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 371.21 E-value: 8.48e-115

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   504 SFAELAVKVNQLTRFLQEN-GARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRMQMMCEDANPLFVLTTQ 582
Cdd:TIGR01733    1 TYRELDERANRLARHLRAAgGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   583 ALAQQLPQnIQQLHLDQEGVQTQIRkQDASDIPAENRKFDFQDVAYVIFTSGSTGRPKGVMNTHGSLLNLILSHkptiyw 662
Cdd:TIGR01733   81 ALASRLAG-LVLPVILLDPLELAAL-DDAPAPPPPDAPSGPDDLAYVIYTSGSTGRPKGVVVTHRSLVNLLAWL------ 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   663 pvleavNERFPDRPL-RAAHTHSFSFDSSWLQVFWMLW-GQELHIFDENMRRDAFGLVQE-IQQRQIDTLDLPPSFcAQM 739
Cdd:TIGR01733  153 ------ARRYGLDPDdRVLQFASLSFDASVEEIFGALLaGATLVVPPEDEERDDAALLAAlIAEHPVTVLNLTPSL-LAL 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   740 MTNGLfVENQHHPSLILIGGEAAPLALWQQLNAQ-PALFAHNLYGPTEYTVDTF-----RAELKQTARPVIGNPIGNTQA 813
Cdd:TIGR01733  226 LAAAL-PPALASLRLVILGGEALTPALVDRWRARgPGARLINLYGPTETTVWSTatlvdPDDAPRESPVPIGRPLANTRL 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   814 YVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPF--EHGQRMYRTGDLVRWNSAGKLEFMGRCDDQIKI 891
Cdd:TIGR01733  305 YVLDDDLRPVPVGVVGELYIGGPGVARGYLNRPELTAERFVPDPFagGDGARLYRTGDLVRYLPDGNLEFLGRIDDQVKI 384

                          410       420
                   ....*....|....*....|....*
gi 490930577   892 RGYRVEIGEVENALSILTNVESAVV 916
Cdd:TIGR01733  385 RGYRIELGEIEAALLRHPGVREAVV 409

A_NRPS_GliP_like

cd17653

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ...

1536-2031

4.07e-114

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 370.10 E-value: 4.07e-114

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1536 QLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQ 1615
Cdd:cd17653     1 DAFERIAAAHPDAVAVESLGGSLTYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLDAK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1616 HPTERIKFMLQDAKSKLVIgeqkdlaaivhpsiatfafnelfdetkvdlssyktTVITPQHPAYLIYTSGTTGQPKGVMV 1695
Cdd:cd17653    81 LPSARIQAILRTSGATLLL-----------------------------------TTDSPDDLAYIIFTSGSTGIPKGVMV 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1696 SHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIApidAHRDPLAllSLIQKyqVTTLHFVPS 1775
Cdd:cd17653   126 PHRGVLNYVSQPPARLDVGPGSRVAQVLSIAFDACIGEIFSTLCNGGTLVLA---DPSDPFA--HVART--VDALMSTPS 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1776 MLAVFEnaateilssaqRQSLP-ICRVFCSGEALPTALAKSFTEhfSCELHNLYGPTEAAVDVSYmdatLGLHPEEScVA 1854
Cdd:cd17653   199 ILSTLS-----------PQDFPnLKTIFLGGEAVPPSLLDRWSP--GRRLYNAYGPTECTISSTM----TELLPGQP-VT 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1855 IGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADGSIQYIG 1934
Cdd:cd17653   261 IGKPIPNSTCYILDADLQPVPEGVVGEICISGVQVARGYLGNPALTASKFVPDPFWPGSRMYRTGDYGRWTEDGGLEFLG 340

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1935 RADDQLKIRGQRIELGEIEQQLRLISGLDVVVHAISSEQNkanvqLVAYLqTTAPVDIDQLKKQLAKHLPAYMVPTHYML 2014
Cdd:cd17653   341 REDNQVKVRGFRINLEEIEEVVLQSQPEVTQAAAIVVNGR-----LVAFV-TPETVDVDGLRSELAKHLPSYAVPDRIIA 414

                         490
                  ....*....|....*..
gi 490930577 2015 VEQFPLSHNGKLDRKAL 2031
Cdd:cd17653   415 LDSFPLTANGKVDRKAL 431

PRK05691

peptide synthase; Validated

41-1288

4.39e-114

peptide synthase; Validated

Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 408.40 E-value: 4.39e-114

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577   41 YTIAHCLELPKTVDIPTFKKAIQIGLNEADTVIASYSSDPSQPFIELNNQVQFQIEEFDFCHLTPKKAQQRLWDWmpSDR 120
Cdd:PRK05691 1751 YNVGGMARLSGVLDVDRFEAALQALILRHETLRTTFPSVDGVPVQQVAEDSGLRMDWQDFSALPADARQQRLQQL--ADS 1828

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  121 QCAKSLKAGETQLFRQVLFTTHD-KVYWYQRYHHIMLDGFSMINLTKRIVELYQQLQEGKD--LSVSPFIGVNEVISERQ 197
Cdd:PRK05691 1829 EAHQPFDLERGPLLRACLVKAAErEHYFVLTLHHIVTEGWAMDIFARELGALYEAFLDDREspLEPLPVQYLDYSVWQRQ 1908

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  198 AYENSH-QFKIDqaFWKAycedlpspiSLSTHH----LAAKTTATFVK-HQ---LRF--STGILEQIQALAAQTKLALNd 266
Cdd:PRK05691 1909 WLESGErQRQLD--YWKA---------QLGNEHplleLPADRPRPPVQsHRgelYRFdlSPELAARVRAFNAQRGLTLF- 1976

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  267 MMMSLSLH-YIYKMTDKAELVNGIPFMRRL--GSKAIRSTLPTVNVLPVKFkvaekDSWVSLAQhVQEQLR----EIRPH 339
Cdd:PRK05691 1977 MTMTATLAaLLYRYSGQRDLRIGAPVANRIrpESEGLIGAFLNTQVLRCQL-----DGQMSVSE-LLEQVRqtviEGQSH 2050

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  340 QKYDAEQILRDLNSIdiHERMYGPILNYK------AFDQDLVIDGEKVKthhistgpiddfefsFIVQD-----HELIIE 408
Cdd:PRK05691 2051 QDLPFDHLVEALQPP--RSAAYNPLFQVMcnvqrwEFQQSRQLAGMTVE---------------YLVNDaratkFDLNLE 2113

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  409 LRADSQR------YTQDeLFN---------HGQRLtllLEQALIRPEQPCSNFNITTPQELTALTQSgIGPRVSHPEQYN 473
Cdd:PRK05691 2114 VTDLDGRlgccltYSRD-LFDepriarmaeHWQNL---LEALLGDPQQRLAELPLLAAAEQQQLLDS-LAGEAGEARLDQ 2188

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  474 NVLDIFYEQVKKYPERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGAS 553
Cdd:PRK05691 2189 TLHGLFAAQAARTPQAPALTFAG----QTLSYAELDARANRLARALRERGVGPQVRVGLALERSLEMVVGLLAILKAGGA 2264

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  554 FLPLDLDYPIDRMQMMCEDANPLFVLTTQALAQ---QLPQNIQQLHLDQEGVQtqIRKQDASDIPAENRKfdfQDVAYVI 630
Cdd:PRK05691 2265 YVPLDPEYPLERLHYMIEDSGIGLLLSDRALFEalgELPAGVARWCLEDDAAA--LAAYSDAPLPFLSLP---QHQAYLI 2339

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  631 FTSGSTGRPKGVMNTHGSllnlILSHkptiywpvLEAVNERFPDRPLRAA-HTHSFSFDSSWLQVFWMLWGQELHIFDEN 709
Cdd:PRK05691 2340 YTSGSTGKPKGVVVSHGE----IAMH--------CQAVIERFGMRADDCElHFYSINFDAASERLLVPLLCGARVVLRAQ 2407

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  710 MRRDAFGLVQEIQQRQIDTLDLPPSFCAQMmTNGLFVENQHHP-SLILIGGEAAPLALWQQLNA--QPALFaHNLYGPTE 786
Cdd:PRK05691 2408 GQWGAEEICQLIREQQVSILGFTPSYGSQL-AQWLAGQGEQLPvRMCITGGEALTGEHLQRIRQafAPQLF-FNAYGPTE 2485

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  787 YTVDTFRA----ELKQTARPV-IGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEH- 860
Cdd:PRK05691 2486 TVVMPLAClapeQLEEGAASVpIGRVVGARVAYILDADLALVPQGATGELYVGGAGLAQGYHDRPGLTAERFVADPFAAd 2565

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  861 GQRMYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSHRLLGYCVVKDIELDE 940
Cdd:PRK05691 2566 GGRLYRTGDLVRLRADGLVEYVGRIDHQVKIRGFRIELGEIESRLLEHPAVREAVVLALDTPSGKQLAGYLVSAVAGQDD 2645

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  941 KTSEQLSQQYLSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALPKPQIRAHSRMAETPEQQL---LCQITASVLKLD 1017
Cdd:PRK05691 2646 EAQAALREALKAHLKQQLPDYMVPAHLILLDSLPLTANGKLDRRALPAPDPELNRQAYQAPRSELeqqLAQIWREVLNVE 2725

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1018 AIGIDDDFFMTGGDSISAIMLCTQLRQRGYSLRPSDVFQFKTVAAMAPQLTRldeqqaavskplfsadlEQKVQEKYGKN 1097
Cdd:PRK05691 2726 RVGLGDNFFELGGDSILSIQVVSRARQLGIHFSPRDLFQHQTVQTLAAVATH-----------------SEAAQAEQGPL 2788

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1098 STILPLLPLQKgMLFLSQVENQSNYNAFTRLSLNGDIDPVRLQQALITVLKRHPQLGGHFDSELAEepvfiyslhptqaW 1177
Cdd:PRK05691 2789 QGASGLTPIQH-WFFDSPVPQPQHWNQALLLEPRQALDPALLEQALQALVEHHDALRLRFSQADGR-------------W 2854

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1178 PVQFCSVTPDLLEQTIQEA-----------LQQPIHLDQ-PygLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDF 1245
Cdd:PRK05691 2855 QAEYRAVTAQELLWQVTVAdfaecaalfadAQRSLDLQQgP--LLRALLVDGPQGQQRLLLAIHHLVVDGVSWRVLLEDL 2932

                        1290      1300      1310      1320      1330
                  ....*....|....*....|....*....|....*....|....*....|.
gi 490930577 1246 IKAYQQ----TNQQLPVLEHS---YETVIKALSGRDH-ETSKVIWQRDLAD 1288
Cdd:PRK05691 2933 QALYRQlsagAEPALPAKTSAfrdWAARLQAYAGSESlREELGWWQAQLGG 2983

A_NRPS_TlmIV_like

cd12114

The adenylation domain of nonribosomal peptide synthetases (NRPS), including ...

1546-2031

2.05e-113

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.

Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 370.06 E-value: 2.05e-113

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1546 PEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFML 1625
Cdd:cd12114     1 PDATAVICGDGTLTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREAIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1626 QDAKSKLVIGEQKDLAAIVHPSIATFAFNElFDETKVDLSSyktTVITPQHPAYLIYTSGTTGQPKGVMVSHQAIVNRIL 1705
Cdd:cd12114    81 ADAGARLVLTDGPDAQLDVAVFDVLILDLD-ALAAPAPPPP---VDVAPDDLAYVIFTSGSTGTPKGVMISHRAALNTIL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1706 WMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPsmlAVFENAAT 1785
Cdd:cd12114   157 DINRRFAVGPDDRVLALSSLSFDLSVYDIFGALSAGATLVLPDEARRRDPAHWAELIERHGVTLWNSVP---ALLEMLLD 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1786 EiLSSAQRQSLPICRVFCSGE----ALPTALAKSFTEhfsCELHNLYGPTEAAVDVSYMDATlGLHPEESCVAIGYPVWN 1861
Cdd:cd12114   234 V-LEAAQALLPSLRLVLLSGDwiplDLPARLRALAPD---ARLISLGGATEASIWSIYHPID-EVPPDWRSIPYGRPLAN 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1862 TQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPftAGQRMYRTGDIARWHADGSIQYIGRADDQLK 1941
Cdd:cd12114   309 QRYRVLDPRGRDCPDWVPGELWIGGRGVALGYLGDPELTAARFVTHP--DGERLYRTGDLGRYRPDGTLEFLGRRDGQVK 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1942 IRGQRIELGEIEQQLRLISGLD-VVVHAIsseQNKANVQLVAYLQTTA---PVDIDQLKKQLAKHLPAYMVPTHYMLVEQ 2017
Cdd:cd12114   387 VRGYRIELGEIEAALQAHPGVArAVVVVL---GDPGGKRLAAFVVPDNdgtPIAPDALRAFLAQTLPAYMIPSRVIALEA 463

                         490
                  ....*....|....
gi 490930577 2018 FPLSHNGKLDRKAL 2031
Cdd:cd12114   464 LPLTANGKVDRAAL 477

A_NRPS_ApnA-like

cd17644

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ...

1533-2032

5.97e-113

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Planktothrix agardhii anabaenopeptin synthetase (ApnA A1), which is capable of activating two chemically distinct amino acids (Arg and Tyr). Structural studies show that the architecture of the active site forces Arg to adopt a Tyr-like conformation, thus explaining the bispecificity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 368.30 E-value: 5.97e-113

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1533 TLQQLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPI 1612
Cdd:cd17644     1 CIHQLFEEQVERTPDAVAVVFEDQQLTYEELNTKANQLAHYLQSLGVKSESLVGICVERSLEMIIGLLAILKAGGAYVPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1613 DLQHPTERIKFMLQDAKSKLVIGEQKDLAaivhpsiatfafnelfdetkvdlssykttvitpqhpaYLIYTSGTTGQPKG 1692
Cdd:cd17644    81 DPNYPQERLTYILEDAQISVLLTQPENLA-------------------------------------YVIYTSGSTGKPKG 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1693 VMVSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHF 1772
Cdd:cd17644   124 VMIEHQSLVNLSHGLIKEYGITSSDRVLQFASIAFDVAAEEIYVTLLSGATLVLRPEEMRSSLEDFVQYIQQWQLTVLSL 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1773 VPSMLAVFENAAT-EILSSAQRQSLpicrVFCSGEALPTALAKSFTEHFS--CELHNLYGPTEAAVDVSYMDATLGLHPE 1849
Cdd:cd17644   204 PPAYWHLLVLELLlSTIDLPSSLRL----VIVGGEAVQPELVRQWQKNVGnfIQLINVYGPTEATIAATVCRLTQLTERN 279

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1850 ESCVAIGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPF--TAGQRMYRTGDIARWHAD 1927
Cdd:cd17644   280 ITSVPIGRPIANTQVYILDENLQPVPVGVPGELHIGGVGLARGYLNRPELTAEKFISHPFnsSESERLYKTGDLARYLPD 359

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1928 GSIQYIGRADDQLKIRGQRIELGEIEQQLRLISGLDVVVhAISSEQNKANVQLVAYL--QTTAPVDIDQLKKQLAKHLPA 2005
Cdd:cd17644   360 GNIEYLGRIDNQVKIRGFRIELGEIEAVLSQHNDVKTAV-VIVREDQPGNKRLVAYIvpHYEESPSTVELRQFLKAKLPD 438

                         490       500
                  ....*....|....*....|....*..
gi 490930577 2006 YMVPTHYMLVEQFPLSHNGKLDRKALP 2032
Cdd:cd17644   439 YMIPSAFVVLEELPLTPNGKIDRRALP 465

A_NRPS_Cytc1-like

cd17643

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...

487-986

4.87e-112

Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 365.09 E-value: 4.87e-112

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  487 PERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRM 566
Cdd:cd17643     1 PEAVAVVDED----RRLTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  567 QMMCEDANPLFVLTtqalaqqlpqniqqlhldqegvqtqirkqdasdipaenrkfDFQDVAYVIFTSGSTGRPKGVMNTH 646
Cdd:cd17643    77 AFILADSGPSLLLT-----------------------------------------DPDDLAYVIYTSGSTGRPKGVVVSH 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  647 GSLLNLilshkptiywpvLEAVnerfpDRPLRAAHT------HSFSFDSSwlqvFWMLWGQELH-----IFDENMRRDAF 715
Cdd:cd17643   116 ANVLAL------------FAAT-----QRWFGFNEDdvwtlfHSYAFDFS----VWEIWGALLHggrlvVVPYEVARSPE 174

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  716 GLVQEIQQRQIDTLDLPPSFCAQMMTnGLFVENQHHPSL--ILIGGEAAPLAL---WQQ--LNAQPALFahNLYGPTEYT 788
Cdd:cd17643   175 DFARLLRDEGVTVLNQTPSAFYQLVE-AADRDGRDPLALryVIFGGEALEAAMlrpWAGrfGLDRPQLV--NMYGITETT 251

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  789 VD-TFR----AELKQTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPF-EHGQ 862
Cdd:cd17643   252 VHvTFRpldaADLPAAAASPIGRPLPGLRVYVLDADGRPVPPGVVGELYVSGAGVARGYLGRPELTAERFVANPFgGPGS 331

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  863 RMYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIA-EPINNSHRLLGYCVVKDieldek 941
Cdd:cd17643   332 RMYRTGDLARRLPDGELEYLGRADEQVKIRGFRIELGEIEAALATHPSVRDAAVIVrEDEPGDTRLVAYVVADD------ 405

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 490930577  942 TSEQLSQQYLSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKAL 986
Cdd:cd17643   406 GAAADIAELRALLKELLPDYMVPARYVPLDALPLTVNGKLDRAAL 450

AMP-binding

AMP-binding enzyme;

1538-1943

1.47e-111

AMP-binding enzyme;

Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 362.40 E-value: 1.47e-111

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1538 LREQARITPEQTALS-DENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQH 1616
Cdd:pfam00501    1 LERQAARTPDKTALEvGEGRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1617 PTERIKFMLQDAKSKLVIGEQKDLAAIVHP--------------SIATFAFNELFDETKVDLSSYKTTVITPQ--HPAYL 1680
Cdd:pfam00501   81 PAEELAYILEDSGAKVLITDDALKLEELLEalgklevvklvlvlDRDPVLKEEPLPEEAKPADVPPPPPPPPDpdDLAYI 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1681 IYTSGTTGQPKGVMVSHQAIVNRILWMQSEYP----LSATDTILQKTPCTFDVSV-WEFFWSYLVGARLVIAPIDAHRDP 1755
Cdd:pfam00501  161 IYTSGTTGKPKGVMLTHRNLVANVLSIKRVRPrgfgLGPDDRVLSTLPLFHDFGLsLGLLGPLLAGATVVLPPGFPALDP 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1756 LALLSLIQKYQVTTLHFVPSMLAVFENAATeiLSSAQRQSLPIcrVFCSGEALPTALAKSFTEHFSCELHNLYGPTEAAV 1835
Cdd:pfam00501  241 AALLELIERYKVTVLYGVPTLLNMLLEAGA--PKRALLSSLRL--VLSGGAPLPPELARRFRELFGGALVNGYGLTETTG 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  1836 DVSYMDatLGLHPEESCVAIGYPVWNTQLYILDQY-LRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVAnpftagQR 1914
Cdd:pfam00501  317 VVTTPL--PLDEDLRSLGSVGRPLPGTEVKIVDDEtGEPVPPGEPGELCVRGPGVMKGYLNDPELTAEAFDE------DG 388

                          410       420
                   ....*....|....*....|....*....
gi 490930577  1915 MYRTGDIARWHADGSIQYIGRADDQLKIR 1943
Cdd:pfam00501  389 WYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417

DltA

cd05945

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ...

1542-2031

1.70e-110

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 360.41 E-value: 1.70e-110

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1542 ARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERI 1621
Cdd:cd05945     1 AAANPDRPAVVEGGRTLTYRELKERADALAAALASLGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSPAERI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1622 KFMLQDAKSKLVIGEQKDLAaivhpsiatfafnelfdetkvdlssykttvitpqhpaYLIYTSGTTGQPKGVMVSHQAIV 1701
Cdd:cd05945    81 REILDAAKPALLIADGDDNA-------------------------------------YIIFTSGSTGRPKGVQISHDNLV 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1702 NRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPS---MLA 1778
Cdd:cd05945   124 SFTNWMLSDFPLGPGDVFLNQAPFSFDLSVMDLYPALASGATLVPVPRDATADPKQLFRFLAEHGITVWVSTPSfaaMCL 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1779 VFENAATEILSSAqRQSLpicrvFCsGEALPTALAKSFTEHF-SCELHNLYGPTEAAVDVSYMDATLGLHPEESCVAIGY 1857
Cdd:cd05945   204 LSPTFTPESLPSL-RHFL-----FC-GEVLPHKTARALQQRFpDARIYNTYGPTEATVAVTYIEVTPEVLDGYDRLPIGY 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1858 PVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPftaGQRMYRTGDIARWHADGSIQYIGRAD 1937
Cdd:cd05945   277 AKPGAKLVILDEDGRPVPPGEKGELVISGPSVSKGYLNNPEKTAAAFFPDE---GQRAYRTGDLVRLEADGLLFYRGRLD 353

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1938 DQLKIRGQRIELGEIEQQLRLISGLDVVVhAISSEQNKANVQLVAYLQTTAPVDI---DQLKKQLAKHLPAYMVPTHYML 2014
Cdd:cd05945   354 FQVKLNGYRIELEEIEAALRQVPGVKEAV-VVPKYKGEKVTELIAFVVPKPGAEAgltKAIKAELAERLPPYMIPRRFVY 432

                         490
                  ....*....|....*..
gi 490930577 2015 VEQFPLSHNGKLDRKAL 2031
Cdd:cd05945   433 LDELPLNANGKIDRKAL 449

A_NRPS_LgrA-like

cd17645

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ...

1535-2032

4.55e-109

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes linear gramicidin synthetase (LgrA) in Brevibacillus brevis. LgrA has a formylation domain fused to the N-terminal end that formylates its substrate for linear gramicidin synthesis to proceed. This formyl group is essential for the clinically important antibacterial activity of gramicidin by enabling head-to-head gramicidin dimers to make a beta-helical pore in gram-positive bacterial membranes, allowing free passage of monovalent cations, destroying the ion gradient and killing bacteria. This family also includes bacitracin synthetase 1 (known as ATP-dependent cysteine adenylase or BA1); it activates cysteine, incorporates two D-amino acids, releases and cyclizes the mature bacitracin, an antibiotic that is a mixture of related cyclic peptides that disrupt gram positive bacteria by interfering with cell wall and peptidoglycan synthesis. Also included is surfactin synthetase which activates and polymerizes the amino acids Leu, Glu, Asp, and Val to form the antibiotic surfactin.

Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 356.09 E-value: 4.55e-109

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1535 QQLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDL 1614
Cdd:cd17645     1 HQLFEEQVERTPDHVAVVDRGQSLTYKQLNEKANQLARHLRGKGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1615 QHPTERIKFMLQDAKSKLVIGEQKDLAaivhpsiatfafnelfdetkvdlssykttvitpqhpaYLIYTSGTTGQPKGVM 1694
Cdd:cd17645    81 DYPGERIAYMLADSSAKILLTNPDDLA-------------------------------------YVIYTSGSTGLPKGVM 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1695 VSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTtLHFVP 1774
Cdd:cd17645   124 IEHHNLVNLCEWHRPYFGVTPADKSLVYASFSFDASAWEIFPHLTAGAALHVVPSERRLDLDALNDYFNQEGIT-ISFLP 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1775 SMLAvfenaatEILSSAQRQSLPIcrVFCSGEALPTALAKSFTehfsceLHNLYGPTEAAVdvsyMDATLGLHPEESCVA 1854
Cdd:cd17645   203 TGAA-------EQFMQLDNQSLRV--LLTGGDKLKKIERKGYK------LVNNYGPTENTV----VATSFEIDKPYANIP 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1855 IGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADGSIQYIG 1934
Cdd:cd17645   264 IGKPIDNTRVYILDEALQLQPIGVAGELCIAGEGLARGYLNRPELTAEKFIVHPFVPGERMYRTGDLAKFLPDGNIEFLG 343

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1935 RADDQLKIRGQRIELGEIEQQLRLISGLDVVVhAISSEQNKANVQLVAYLQTTAPVDIDQLKKQLAKHLPAYMVPTHYML 2014
Cdd:cd17645   344 RLDQQVKIRGYRIEPGEIEPFLMNHPLIELAA-VLAKEDADGRKYLVAYVTAPEEIPHEELREWLKNDLPDYMIPTYFVH 422

                         490
                  ....*....|....*...
gi 490930577 2015 VEQFPLSHNGKLDRKALP 2032
Cdd:cd17645   423 LKALPLTANGKVDRKALP 440

A_NRPS_ApnA-like

cd17644

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ...

478-987

4.42e-108

Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 354.05 E-value: 4.42e-108

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  478 IFYEQVKKYPERTAIVSgERpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPL 557
Cdd:cd17644     5 LFEEQVERTPDAVAVVF-ED---QQLTYEELNTKANQLAHYLQSLGVKSESLVGICVERSLEMIIGLLAILKAGGAYVPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  558 DLDYPIDRMQMMCEDANpLFVLTTQalaqqlPQNIqqlhldqegvqtqirkqdasdipaenrkfdfqdvAYVIFTSGSTG 637
Cdd:cd17644    81 DPNYPQERLTYILEDAQ-ISVLLTQ------PENL----------------------------------AYVIYTSGSTG 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  638 RPKGVMNTHGSLLNLIlshkptiyWPVLEAVNERFPDRPLRAAhthSFSFDSSWLQVFwMLW--GQELHIFDENMRRDAF 715
Cdd:cd17644   120 KPKGVMIEHQSLVNLS--------HGLIKEYGITSSDRVLQFA---SIAFDVAAEEIY-VTLlsGATLVLRPEEMRSSLE 187

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  716 GLVQEIQQRQIDTLDLPPSFCAQMMTNGL--FVENQHHPSLILIGGEAAPLALWQQL--NAQPALFAHNLYGPTEYTVDT 791
Cdd:cd17644   188 DFVQYIQQWQLTVLSLPPAYWHLLVLELLlsTIDLPSSLRLVIVGGEAVQPELVRQWqkNVGNFIQLINVYGPTEATIAA 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  792 FRAELK-----QTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEH--GQRM 864
Cdd:cd17644   268 TVCRLTqlterNITSVPIGRPIANTQVYILDENLQPVPVGVPGELHIGGVGLARGYLNRPELTAEKFISHPFNSseSERL 347

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  865 YRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIA-EPINNSHRLLGYcVVKDIELDEKTS 943
Cdd:cd17644   348 YKTGDLARYLPDGNIEYLGRIDNQVKIRGFRIELGEIEAVLSQHNDVKTAVVIVrEDQPGNKRLVAY-IVPHYEESPSTV 426

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 490930577  944 EQlsQQYLSqlrQNLPEYMVPSALTVMSEFPRNVSGKVDKKALP 987
Cdd:cd17644   427 EL--RQFLK---AKLPDYMIPSAFVVLEELPLTPNGKIDRRALP 465

MenE/FadK

COG0318

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...

1534-2037

6.07e-108

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis

Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 353.35 E-value: 6.07e-108

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1534 LQQLLREQARITPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPID 1613
Cdd:COG0318     1 LADLLRRAAARHPDRPALVFGGRRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1614 LQHPTERIKFMLQDAKSKLVIGeqkdlaaivhpsiatfafnelfdetkvdlssykttvitpqhpAYLIYTSGTTGQPKGV 1693
Cdd:COG0318    81 PRLTAEELAYILEDSGARALVT------------------------------------------ALILYTSGTTGRPKGV 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1694 MVSHQAIVNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYL-VGARLVIAPidaHRDPLALLSLIQKYQVTTLHF 1772
Cdd:COG0318   119 MLTHRNLLANAAAIAAALGLTPGDVVLVALPLFHVFGLTVGLLAPLlAGATLVLLP---RFDPERVLELIERERVTVLFG 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1773 VPSM---LAVFENAATEILSSAQrqslpicRVFCSGEALPTALAKSFTEHFSCELHNLYGPTEAAVDVSYMDATLGLHPE 1849
Cdd:COG0318   196 VPTMlarLLRHPEFARYDLSSLR-------LVVSGGAPLPPELLERFEERFGVRIVEGYGLTETSPVVTVNPEDPGERRP 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1850 ESCvaiGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVanpftagQRMYRTGDIARWHADGS 1929
Cdd:COG0318   269 GSV---GRPLPGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPEATAEAFR-------DGWLRTGDLGRLDEDGY 338

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1930 IQYIGRADDQLKIRGQRIELGEIEQQLRLISG-LDVVV----HAISSEQNKANVQLVAylqtTAPVDIDQLKKQLAKHLP 2004
Cdd:COG0318   339 LYIVGRKKDMIISGGENVYPAEVEEVLAAHPGvAEAAVvgvpDEKWGERVVAFVVLRP----GAELDAEELRAFLRERLA 414

                         490       500       510
                  ....*....|....*....|....*....|...
gi 490930577 2005 AYMVPTHYMLVEQFPLSHNGKLDRKALPQPHLT 2037
Cdd:COG0318   415 RYKVPRRVEFVDELPRTASGKIDRRALRERYAA 447

A_NRPS_Sfm_like

cd12115

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ...

477-986

1.98e-107

Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 351.62 E-value: 1.98e-107

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  477 DIFYEQVKKYPERTAIVSGERpnlqHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLP 556
Cdd:cd12115     3 DLVEAQAARTPDAIALVCGDE----SLTYAELNRRANRLAARLRAAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  557 LDLDYPIDRMQMMCEDANPLFVLTtqalaqqlpqniqqlhldqegvqtqirkqdasdipaenrkfDFQDVAYVIFTSGST 636
Cdd:cd12115    79 LDPAYPPERLRFILEDAQARLVLT-----------------------------------------DPDDLAYVIYTSGST 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  637 GRPKGVMNTHGSLLNLIlshkptiYWpvleaVNERFPDRPLRA--AHThSFSFDSSWLQVFWML-WGQELHIFDenmrrD 713
Cdd:cd12115   118 GRPKGVAIEHRNAAAFL-------QW-----AAAAFSAEELAGvlAST-SICFDLSVFELFGPLaTGGKVVLAD-----N 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  714 AFGLVQEIQQRQIDTLDLPPSFCAQMMTNGLFVENQhhpSLILIGGEAAPLALWQQLNAQ-PALFAHNLYGPTEYTV-DT 791
Cdd:cd12115   180 VLALPDLPAAAEVTLINTVPSAAAELLRHDALPASV---RVVNLAGEPLPRDLVQRLYARlQVERVVNLYGPSEDTTyST 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  792 FRAELKQTARPV-IGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQRMYRTGDL 870
Cdd:cd12115   257 VAPVPPGASGEVsIGRPLANTQAYVLDRALQPVPLGVPGELYIGGAGVARGYLGRPGLTAERFLPDPFGPGARLYRTGDL 336

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  871 VRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIA-EPINNSHRLLGYCVVKDieldekTSEQLSQQ 949
Cdd:cd12115   337 VRWRPDGLLEFLGRADNQVKVRGFRIELGEIEAALRSIPGVREAVVVAiGDAAGERRLVAYIVAEP------GAAGLVED 410

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 490930577  950 YLSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKAL 986
Cdd:cd12115   411 LRRHLGTRLPAYMVPSRFVRLDALPLTPNGKIDRSAL 447

A_NRPS_PvdJ-like

cd17649

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ...

487-987

2.55e-107

Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 351.29 E-value: 2.55e-107

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  487 PERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRM 566
Cdd:cd17649     1 PDAVALVFGD----QSLSYAELDARANRLAHRLRALGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  567 QMMCEDANPLFVLTtqalaqQLPQNIqqlhldqegvqtqirkqdasdipaenrkfdfqdvAYVIFTSGSTGRPKGVMNTH 646
Cdd:cd17649    77 RYMLEDSGAGLLLT------HHPRQL----------------------------------AYVIYTSGSTGTPKGVAVSH 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  647 GSLLNLIlshkptiywpvlEAVNERFP----DRPLRAAhthSFSFDSSWLQVFW-MLWGQELHIFDENMRRDAFGLVQEI 721
Cdd:cd17649   117 GPLAAHC------------QATAERYGltpgDRELQFA---SFNFDGAHEQLLPpLICGACVVLRPDELWASADELAEMV 181

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  722 QQRQIDTLDLPPSFCAQMMTNGLFVENQHHPSL--ILIGGEAAPLALWQQLNAQPALFAhNLYGPTEYTV-----DTFRA 794
Cdd:cd17649   182 RELGVTVLDLPPAYLQQLAEEADRTGDGRPPSLrlYIFGGEALSPELLRRWLKAPVRLF-NAYGPTEATVtplvwKCEAG 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  795 ELKQTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPF-EHGQRMYRTGDLVRW 873
Cdd:cd17649   261 AARAGASMPIGRPLGGRSAYILDADLNPVPVGVTGELYIGGEGLARGYLGRPELTAERFVPDPFgAPGSRLYRTGDLARW 340

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  874 NSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSHRLLGYCVVKDIELDEKTSEQLSQqylsQ 953
Cdd:cd17649   341 RDDGVIEYLGRVDHQVKIRGFRIELGEIEAALLEHPGVREAAVVALDGAGGKQLVAYVVLRAAAAQPELRAQLRT----A 416

                         490       500       510
                  ....*....|....*....|....*....|....
gi 490930577  954 LRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALP 987
Cdd:cd17649   417 LRASLPDYMVPAHLVFLARLPLTPNGKLDRKALP 450

A_NRPS_ProA

cd17656

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ...

1545-2032

6.73e-105

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains gramicidin S synthase 2 (also known as ATP-dependent proline adenylase or proline activase or ProA). ProA is a multifunctional enzyme involved in synthesis of the cyclic peptide antibiotic gramicidin S and able to activate and polymerize the amino acids proline, valine, ornithine and leucine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.

Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 345.61 E-value: 6.73e-105

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1545 TPEQTALSDENHQLSFSEVRLQVCALAQQLQRAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFM 1624
Cdd:cd17656     1 TPDAVAVVFENQKLTYRELNERSNQLARFLREKGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1625 LQDAKSKLVIGEQKdlaaivHPSIATFAFN----ELFDETKVDLSSYkTTVITPQHPAYLIYTSGTTGQPKGVMVSHQAI 1700
Cdd:cd17656    81 MLDSGVRVVLTQRH------LKSKLSFNKStillEDPSISQEDTSNI-DYINNSDDLLYIIYTSGTTGKPKGVQLEHKNM 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1701 VNRILWMQSEYPLSATDTILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLhFVPSMLAVF 1780
Cdd:cd17656   154 VNLLHFEREKTNINFSDKVLQFATCSFDVCYQEIFSTLLSGGTLYIIREETKRDVEQLFDLVKRHNIEVV-FLPVAFLKF 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1781 enaateILSSAQ-RQSLPIC--RVFCSGEALptALAKSFTEHF---SCELHNLYGPTEAAVDVSYMdatlgLHPEESCV- 1853
Cdd:cd17656   233 ------IFSEREfINRFPTCvkHIITAGEQL--VITNEFKEMLhehNVHLHNHYGPSETHVVTTYT-----INPEAEIPe 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1854 --AIGYPVWNTQLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQRMYRTGDIARWHADGSIQ 1931
Cdd:cd17656   300 lpPIGKPISNTWIYILDQEQQLQPQGIVGELYISGASVARGYLNRQELTAEKFFPDPFDPNERMYRTGDLARYLPDGNIE 379

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1932 YIGRADDQLKIRGQRIELGEIEQQLRLISGLDVVVHAISSEQNKANvQLVAYLQTTAPVDIDQLKKQLAKHLPAYMVPTH 2011
Cdd:cd17656   380 FLGRADHQVKIRGYRIELGEIEAQLLNHPGVSEAVVLDKADDKGEK-YLCAYFVMEQELNISQLREYLAKQLPEYMIPSF 458

                         490       500
                  ....*....|....*....|.
gi 490930577 2012 YMLVEQFPLSHNGKLDRKALP 2032
Cdd:cd17656   459 FVPLDQLPLTPNGKVDRKALP 479

A_NRPS_ACVS-like

cd17648

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ...

1546-2032

7.06e-102

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV synthetase (ACVS, EC 6.3.2.26; also known as N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase or delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase) is involved in medically important antibiotic biosynthesis. ACV synthetase is active in an early step in the penicillin G biosynthesis pathway which involves the formation of the tripeptide 6-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV); each of the constituent amino acids of the tripeptide ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. ACV is then cyclized by the action of isopenicillin N synthase.

Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 335.91 E-value: 7.06e-102

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1546 PEQTALSDENHQLSFSEVRLQVCALAQQLQ-RAGVQAGDIVAVALPRSVKLSIAILAVIEAGAAYLPIDLQHPTERIKFM 1624
Cdd:cd17648     1 PDRVAVVYGDKRLTYRELNERANRLAHYLLsVAEIRPDDLVGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDERIQFI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1625 LQDAKSKLVIGEQKDLAaivhpsiatfafnelfdetkvdlssykttvitpqhpaYLIYTSGTTGQPKGVMVSHQAIVNRI 1704
Cdd:cd17648    81 LEDTGARVVITNSTDLA-------------------------------------YAIYTSGTTGKPKGVLVEHGSVVNLR 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1705 LWMQSEYPLSATDT--ILQKTPCTFDVSVWEFFWSYLVGARLVIAPIDAHRDPLALLSLIQKYQVTTLHFVPSMLAVFEn 1782
Cdd:cd17648   124 TSLSERYFGRDNGDeaVLFFSNYVFDFFVEQMTLALLNGQKLVVPPDEMRFDPDRFYAYINREKVTYLSGTPSVLQQYD- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1783 aateiLSSaqRQSLPicRVFCSGEALPTALAKSFTEHFSCELHNLYGPTEAAVdvsYMDATLGLHPEESCVAIGYPVWNT 1862
Cdd:cd17648   203 -----LAR--LPHLK--RVDAAGEEFTAPVFEKLRSRFAGLIINAYGPTETTV---TNHKRFFPGDQRFDKSLGRPVRNT 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1863 QLYILDQYLRPVPVGVDGELYLAGHQLAMGYLHRADLTASRFVANPFTAGQ--------RMYRTGDIARWHADGSIQYIG 1934
Cdd:cd17648   271 KCYVLNDAMKRVPVGAVGELYLGGDGVARGYLNRPELTAERFLPNPFQTEQerargrnaRLYKTGDLVRWLPSGELEYLG 350

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1935 RADDQLKIRGQRIELGEIEQQLRLISGLD--VVVHAISSEQNKANVQ--LVA-YLQTTAPVDIDQLKKQLAKHLPAYMVP 2009
Cdd:cd17648   351 RNDFQVKIRGQRIEPGEVEAALASYPGVRecAVVAKEDASQAQSRIQkyLVGyYLPEPGHVPESDLLSFLRAKLPRYMVP 430

                         490       500
                  ....*....|....*....|...
gi 490930577 2010 THYMLVEQFPLSHNGKLDRKALP 2032
Cdd:cd17648   431 ARLVRLEGIPVTINGKLDVRALP 453

A_NRPS_TlmIV_like

cd12114

The adenylation domain of nonribosomal peptide synthetases (NRPS), including ...

487-986

7.61e-102

Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 336.55 E-value: 7.61e-102

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  487 PERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRM 566
Cdd:cd12114     1 PDATAVICGD----GTLTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  567 QMMCEDANPLFVLTTQALAQQLPQNIQQLHLDQEgvqtqirKQDASDIPAEnRKFDFQDVAYVIFTSGSTGRPKGVMNTH 646
Cdd:cd12114    77 EAILADAGARLVLTDGPDAQLDVAVFDVLILDLD-------ALAAPAPPPP-VDVAPDDLAYVIFTSGSTGTPKGVMISH 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  647 GSLLNLIlshkptiywpvlEAVNERF----PDRPLRAAhthSFSFDSSWLQVFWML-WGQELHIFDENMRRDAFGLVQEI 721
Cdd:cd12114   149 RAALNTI------------LDINRRFavgpDDRVLALS---SLSFDLSVYDIFGALsAGATLVLPDEARRRDPAHWAELI 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  722 QQRQIDTLDLPPSFcAQMMTNGLFVENQHHPSL--ILIGGEAAPLAL---WQQLNAQPALFAhnLYGPTE-------YTV 789
Cdd:cd12114   214 ERHGVTLWNSVPAL-LEMLLDVLEAAQALLPSLrlVLLSGDWIPLDLparLRALAPDARLIS--LGGATEasiwsiyHPI 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  790 DTFRAELKqtarpVI--GNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPfeHGQRMYRT 867
Cdd:cd12114   291 DEVPPDWR-----SIpyGRPLANQRYRVLDPRGRDCPDWVPGELWIGGRGVALGYLGDPELTAARFVTHP--DGERLYRT 363

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  868 GDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSHRLLGYcVVKDIELDEKTSEQLS 947
Cdd:cd12114   364 GDLGRYRPDGTLEFLGRRDGQVKVRGYRIELGEIEAALQAHPGVARAVVVVLGDPGGKRLAAF-VVPDNDGTPIAPDALR 442

                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 490930577  948 QqylsQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKAL 986
Cdd:cd12114   443 A----FLAQTLPAYMIPSRVIALEALPLTANGKVDRAAL 477

A_NRPS_ProA

cd17656

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ...

487-987

1.95e-94

Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 315.18 E-value: 1.95e-94

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  487 PERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRM 566
Cdd:cd17656     2 PDAVAVVFEN----QKLTYRELNERSNQLARFLREKGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  567 QMMCEDANPLFVLTTQALAQQLPQNIQQLHLDQEgvqtQIRKQDASDIPAENRKfdfQDVAYVIFTSGSTGRPKGVMNTH 646
Cdd:cd17656    78 IYIMLDSGVRVVLTQRHLKSKLSFNKSTILLEDP----SISQEDTSNIDYINNS---DDLLYIIYTSGTTGKPKGVQLEH 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  647 GSLLNLILSHKptiywpvlEAVNERFPDRPLRAAhthSFSFDSSWLQVF-WMLWGQELHIFDENMRRDAFGLVQEIQQRQ 725
Cdd:cd17656   151 KNMVNLLHFER--------EKTNINFSDKVLQFA---TCSFDVCYQEIFsTLLSGGTLYIIREETKRDVEQLFDLVKRHN 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  726 IDTLDLPPSFCAQmmtngLFVENQHHPSL------ILIGGEAAPLA-LWQQLNAQPALFAHNLYGPTE---YTVDTFRAE 795
Cdd:cd17656   220 IEVVFLPVAFLKF-----IFSEREFINRFptcvkhIITAGEQLVITnEFKEMLHEHNVHLHNHYGPSEthvVTTYTINPE 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  796 LKQTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQRMYRTGDLVRWNS 875
Cdd:cd17656   295 AEIPELPPIGKPISNTWIYILDQEQQLQPQGIVGELYISGASVARGYLNRQELTAEKFFPDPFDPNERMYRTGDLARYLP 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  876 AGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIA-EPINNSHRLLGYCVVkdieLDEKTSEQLSqqylSQL 954
Cdd:cd17656   375 DGNIEFLGRADHQVKIRGYRIELGEIEAQLLNHPGVSEAVVLDkADDKGEKYLCAYFVM----EQELNISQLR----EYL 446

                         490       500       510
                  ....*....|....*....|....*....|...
gi 490930577  955 RQNLPEYMVPSALTVMSEFPRNVSGKVDKKALP 987
Cdd:cd17656   447 AKQLPEYMIPSFFVPLDQLPLTPNGKVDRKALP 479

A_NRPS_LgrA-like

cd17645

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ...

478-987

3.02e-94

Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 313.34 E-value: 3.02e-94

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  478 IFYEQVKKYPERTAIVSgerpNLQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPL 557
Cdd:cd17645     3 LFEEQVERTPDHVAVVD----RGQSLTYKQLNEKANQLARHLRGKGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  558 DLDYPIDRMQMMCEDANPLFVLTtqalaqqlpqniqqlhldqegvqtqirkqdasdipaenrkfDFQDVAYVIFTSGSTG 637
Cdd:cd17645    79 DPDYPGERIAYMLADSSAKILLT-----------------------------------------NPDDLAYVIYTSGSTG 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  638 RPKGVMNTHGSLLNLILSHKPtiYWPVLEAvnerfpDRPLRAAhthSFSFDSSWLQVF-WMLWGQELHIFDENMRRDAFG 716
Cdd:cd17645   118 LPKGVMIEHHNLVNLCEWHRP--YFGVTPA------DKSLVYA---SFSFDASAWEIFpHLTAGAALHVVPSERRLDLDA 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  717 LVQEIQQRQIDTLDLPPSFCAQMMTnglfVENqHHPSLILIGGEAAplalwQQLNAQPALFAHNlYGPTEYTVDTFRAEL 796
Cdd:cd17645   187 LNDYFNQEGITISFLPTGAAEQFMQ----LDN-QSLRVLLTGGDKL-----KKIERKGYKLVNN-YGPTENTVVATSFEI 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  797 -KQTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQRMYRTGDLVRWNS 875
Cdd:cd17645   256 dKPYANIPIGKPIDNTRVYILDEALQLQPIGVAGELCIAGEGLARGYLNRPELTAEKFIVHPFVPGERMYRTGDLAKFLP 335

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  876 AGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIA-EPINNSHRLLGYCVVKdielDEKTSEQLSqqylSQL 954
Cdd:cd17645   336 DGNIEFLGRLDQQVKIRGYRIEPGEIEPFLMNHPLIELAAVLAkEDADGRKYLVAYVTAP----EEIPHEELR----EWL 407

                         490       500       510
                  ....*....|....*....|....*....|...
gi 490930577  955 RQNLPEYMVPSALTVMSEFPRNVSGKVDKKALP 987
Cdd:cd17645   408 KNDLPDYMIPTYFVHLKALPLTANGKVDRKALP 440

A_NRPS_SidN3_like

cd05918

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ...

475-986

8.45e-94

Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 313.71 E-value: 8.45e-94

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  475 VLDIFYEQVKKYPERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASF 554
Cdd:cd05918     1 VHDLIEERARSQPDAPAVCAWD----GSLTYAELDRLSSRLAHHLRSLGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  555 LPLDLDYPIDRMQMMCEDANPLFVLTTQAlaqqlpqniqqlhldqegvqtqirkqdasdipaenrkfdfQDVAYVIFTSG 634
Cdd:cd05918    77 VPLDPSHPLQRLQEILQDTGAKVVLTSSP----------------------------------------SDAAYVIFTSG 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  635 STGRPKGVMNTHGSLLNLILSHKPtiywpvLEAVNERfpDRPLRAAhthSFSFDSSWLQVFWMLwgqelhIF-------- 706
Cdd:cd05918   117 STGKPKGVVIEHRALSTSALAHGR------ALGLTSE--SRVLQFA---SYTFDVSILEIFTTL------AAggclcips 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  707 DENMRRDafgLVQEIQQRQIDTLDLPPSFcAQMMTNGLFvenqhhPSL--ILIGGEAAPLALWQQLNAQPALFahNLYGP 784
Cdd:cd05918   180 EEDRLND---LAGFINRLRVTWAFLTPSV-ARLLDPEDV------PSLrtLVLGGEALTQSDVDTWADRVRLI--NAYGP 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  785 TEYTVDTFRAELKQTARP-VIGNPIGNTqAYVLD--RHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANP---- 857
Cdd:cd05918   248 AECTIAATVSPVVPSTDPrNIGRPLGAT-CWVVDpdNHDRLVPIGAVGELLIEGPILARGYLNDPEKTAAAFIEDPawlk 326

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  858 ---FEHGQRMYRTGDLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALS----ILTNVESAVVIAEPINNSHRLLGY 930
Cdd:cd05918   327 qegSGRGRRLYRTGDLVRYNPDGSLEYVGRKDTQVKIRGQRVELGEIEHHLRqslpGAKEVVVEVVKPKDGSSSPQLVAF 406

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490930577  931 CVVKDIELDEKTSEQLSQQYLSQ-----------LRQNLPEYMVPSALTVMSEFPRNVSGKVDKKAL 986
Cdd:cd05918   407 VVLDGSSSGSGDGDSLFLEPSDEfralvaelrskLRQRLPSYMVPSVFLPLSHLPLTASGKIDRRAL 473

A_NRPS_PpsD_like

cd17650

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ...

487-986

2.69e-92

Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 307.86 E-value: 2.69e-92

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  487 PERTAIVSGERpnlqHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDRM 566
Cdd:cd17650     1 PDAIAVSDATR----QLTYRELNERANQLARTLRGLGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  567 QMMCEDANPLFVLTtqalaqqlpqniqqlhldqegvqtqirkqdasdipaenrkfDFQDVAYVIFTSGSTGRPKGVMNTH 646
Cdd:cd17650    77 QYMLEDSGAKLLLT-----------------------------------------QPEDLAYVIYTSGTTGKPKGVMVEH 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  647 GSLLNLILShkptiyWPVLEAVnERFPDRPLRAAhthSFSFDsswlqVFW------MLWGQELHIFDENMRRDAFGLVQE 720
Cdd:cd17650   116 RNVAHAAHA------WRREYEL-DSFPVRLLQMA---SFSFD-----VFAgdfarsLLNGGTLVICPDEVKLDPAALYDL 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  721 IQQRQIDTLDLPPSFCAQMMTngLFVENQHHPS---LILIGGEAAPLALWQQLNAQpaLFAH----NLYGPTEYTVDTF- 792
Cdd:cd17650   181 ILKSRITLMESTPALIRPVMA--YVYRNGLDLSamrLLIVGSDGCKAQDFKTLAAR--FGQGmriiNSYGVTEATIDSTy 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  793 ----RAELKQTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQRMYRTG 868
Cdd:cd17650   257 yeegRDPLGDSANVPIGRPLPNTAMYVLDERLQPQPVGVAGELYIGGAGVARGYLNRPELTAERFVENPFAPGERMYRTG 336

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  869 DLVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSH-RLLGYCVVkdielDEKTSEQLS 947
Cdd:cd17650   337 DLARWRADGNVELLGRVDHQVKIRGFRIELGEIESQLARHPAIDEAVVAVREDKGGEaRLCAYVVA-----AATLNTAEL 411

                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 490930577  948 QQYLSqlrQNLPEYMVPSALTVMSEFPRNVSGKVDKKAL 986
Cdd:cd17650   412 RAFLA---KELPSYMIPSYYVQLDALPLTPNGKVDRRAL 447

A_NRPS_ACVS-like

cd17648

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ...

487-987

5.96e-89

Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 298.54 E-value: 5.96e-89

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  487 PERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGA-RKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYPIDR 565
Cdd:cd17648     1 PDRVAVVYGD----KRLTYRELNERANRLAHYLLSVAEiRPDDLVGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDER 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  566 MQMMCEDANPLFVLTtqalaqqlpqniqqlhldqegvqtqirkqdasdipaenrkfDFQDVAYVIFTSGSTGRPKGVMNT 645
Cdd:cd17648    77 IQFILEDTGARVVIT-----------------------------------------NSTDLAYAIYTSGTTGKPKGVLVE 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  646 HGSLLNLILShkptiywpvleaVNERFPDRPLRAAHTHSFS---FDSSWLQ-VFWMLWGQELHIFDENMRRDAFGLVQEI 721
Cdd:cd17648   116 HGSVVNLRTS------------LSERYFGRDNGDEAVLFFSnyvFDFFVEQmTLALLNGQKLVVPPDEMRFDPDRFYAYI 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  722 QQRQIDTLDLPPSFCAQmmtnglfVENQHHPSL--ILIGGEAAPLALWQQLNAQPALFAHNLYGPTEYTVDTFRAELKQT 799
Cdd:cd17648   184 NREKVTYLSGTPSVLQQ-------YDLARLPHLkrVDAAGEEFTAPVFEKLRSRFAGLIINAYGPTETTVTNHKRFFPGD 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  800 AR--PVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQ--------RMYRTGD 869
Cdd:cd17648   257 QRfdKSLGRPVRNTKCYVLNDAMKRVPVGAVGELYLGGDGVARGYLNRPELTAERFLPNPFQTEQerargrnaRLYKTGD 336

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  870 LVRWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSH------RLLGYCVVKDIELDEkts 943
Cdd:cd17648   337 LVRWLPSGELEYLGRNDFQVKIRGQRIEPGEVEAALASYPGVRECAVVAKEDASQAqsriqkYLVGYYLPEPGHVPE--- 413

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 490930577  944 eqlsQQYLSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKALP 987
Cdd:cd17648   414 ----SDLLSFLRAKLPRYMVPARLVRLEGIPVTINGKLDVRALP 453

DCL_NRPS

cd19543

DCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs), which catalyzes the ...

1100-1501

4.86e-88

DCL-type Condensation domain of nonribosomal peptide synthetases (NRPSs), which catalyzes the condensation between a D-aminoacyl/peptidyl-PCP donor and a L-aminoacyl-PCP acceptor; The DCL-type Condensation (C) domain catalyzes the condensation between a D-aminoacyl/peptidyl-PCP donor and a L-aminoacyl-PCP acceptor. This domain is D-specific for the peptidyl donor and L-specific for the aminoacyl acceptor ((D)C(L)); this is in contrast with the standard LCL domains which catalyze peptide bond formation between two L-amino acids, and the restriction of ribosomes to use only L-amino acids. C domains of nonribosomal peptide synthetases (NRPSs) catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains in addition to the LCL- and DCL-types such as starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.

Pssm-ID: 380465 [Multi-domain] Cd Length: 423 Bit Score: 294.88 E-value: 4.86e-88

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1100 ILPLLPLQKGMLFLSQVENQSN-YNAFTRLSLNGDIDPVRLQQALITVLKRHPQLGGHFDSELAEEPVFIysLHPTQAWP 1178
Cdd:cd19543     1 IYPLSPMQEGMLFHSLLDPGSGaYVEQMVITLEGPLDPDRFRAAWQAVVDRHPILRTSFVWEGLGEPLQV--VLKDRKLP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1179 VQF---CSVTPDLLEQTIQEAL----QQPIHLDQPyGLIRATLIQHAPEQSELLIMVHHLLTDGWSTPLFLQDFIKAYQ- 1250
Cdd:cd19543    79 WREldlSHLSEAEQEAELEALAeedrERGFDLARA-PLMRLTLIRLGDDRYRLVWSFHHILLDGWSLPILLKELFAIYAa 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1251 QTNQQLPVLE--HSYETVIKALSGRDHETSKVIWQRDLADL--QPLILFNQA-----QQAVQETSYRLSAELGAKLQHKL 1321
Cdd:cd19543   158 LGEGQPPSLPpvRPYRDYIAWLQRQDKEAAEAYWREYLAGFeePTPLPKELPadadgSYEPGEVSFELSAELTARLQELA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1322 RQQGITLNVFMQMIWAMTLNIYAHREDIVFGTPVSGRSAPINGLEQQIGLFLNTIPVRVKLNMQQTLWEQLPQLQQLHVE 1401
Cdd:cd19543   238 RQHGVTLNTVVQGAWALLLSRYSGRDDVVFGTTVSGRPAELPGIETMVGLFINTLPVRVRLDPDQTVLELLKDLQAQQLE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577 1402 HLEHDGLGLSAIQQLIAQG-NLFDSLLVVENYPDNQYLQQKLGDAA--ISKLTNRGYSHYPLALLVIPDHQIELLLE-QR 1477
Cdd:cd19543   318 LREHEYVPLYEIQAWSEGKqALFDHLLVFENYPVDESLEEEQDEDGlrITDVSAEEQTNYPLTVVAIPGEELTIKLSyDA 397

                         410       420
                  ....*....|....*....|....*.
gi 490930577 1478 GVIDQP--EHFLERMIQLIEIALNEP 1501
Cdd:cd19543   398 EVFDEAtiERLLGHLRRVLEQVAANP 423

DltA

cd05945

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ...

483-986

1.50e-87

Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 294.15 E-value: 1.50e-87

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  483 VKKYPERTAIVSGERPnlqhLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLPLDLDYP 562
Cdd:cd05945     1 AAANPDRPAVVEGGRT----LTYRELKERADALAAALASLGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  563 IDRMQMMCEDANPLFVLTTQAlaqqlpqniqqlhldqegvqtqirkqdasdipaenrkfdfqDVAYVIFTSGSTGRPKGV 642
Cdd:cd05945    77 AERIREILDAAKPALLIADGD-----------------------------------------DNAYIIFTSGSTGRPKGV 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  643 MNTHGSLLNLIlshkptiywpvlEAVNERFPDRP-LRAAHTHSFSFDSSWLQVF--WMLwGQELHIFDENMRRDAFGLVQ 719
Cdd:cd05945   116 QISHDNLVSFT------------NWMLSDFPLGPgDVFLNQAPFSFDLSVMDLYpaLAS-GATLVPVPRDATADPKQLFR 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  720 EIQQRQIDTLDLPPSFCAQMMTNGLFVEnQHHPSL--ILIGGEAAPLALWQQL-NAQPALFAHNLYGPTEYTVDT----F 792
Cdd:cd05945   183 FLAEHGITVWVSTPSFAAMCLLSPTFTP-ESLPSLrhFLFCGEVLPHKTARALqQRFPDARIYNTYGPTEATVAVtyieV 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  793 RAELKQTARPV-IGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPfehGQRMYRTGDLV 871
Cdd:cd05945   262 TPEVLDGYDRLpIGYAKPGAKLVILDEDGRPVPPGEKGELVISGPSVSKGYLNNPEKTAAAFFPDE---GQRAYRTGDLV 338

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  872 RWNSAGKLEFMGRCDDQIKIRGYRVEIGEVENALSILTNVESAVVIAEPINNSH-RLLGYcvvkdIELDEKTSEQLSQQY 950
Cdd:cd05945   339 RLEADGLLFYRGRLDFQVKLNGYRIELEEIEAALRQVPGVKEAVVVPKYKGEKVtELIAF-----VVPKPGAEAGLTKAI 413

                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 490930577  951 LSQLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKAL 986
Cdd:cd05945   414 KAELAERLPPYMIPRRFVYLDELPLNANGKIDRKAL 449

A_NRPS_GliP_like

cd17653

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ...

477-986

1.51e-87

Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 293.83 E-value: 1.51e-87

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  477 DIFYEQVKKYPERTAIVSGErpnlQHLSFAELAVKVNQLTRFLQENGARKQTVIAGAIPRSIDSVVVMLSVLNSGASFLP 556
Cdd:cd17653     1 DAFERIAAAHPDAVAVESLG----GSLTYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  557 LDLDYPIDRMQMMCEDANPLFVLTTqalaqqlpqniqqlhldqegvqtqirkqDASDipaenrkfdfqDVAYVIFTSGST 636
Cdd:cd17653    77 LDAKLPSARIQAILRTSGATLLLTT----------------------------DSPD-----------DLAYIIFTSGST 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  637 GRPKGVMNTHGSLLNLilshkptiywpvLEAVNERFPDRP-LRAAHTHSFSFDSSWLQVFWML-WGQELHIFDENmrrDA 714
Cdd:cd17653   118 GIPKGVMVPHRGVLNY------------VSQPPARLDVGPgSRVAQVLSIAFDACIGEIFSTLcNGGTLVLADPS---DP 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  715 FGLVQeiqqRQIDTLDLPPSFCAQmmtnglfVENQHHPSL--ILIGGEAAPLALWQQLNAQPALFahNLYGPTEYTVDTF 792
Cdd:cd17653   183 FAHVA----RTVDALMSTPSILST-------LSPQDFPNLktIFLGGEAVPPSLLDRWSPGRRLY--NAYGPTECTISST 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  793 RAELKQTARPVIGNPIGNTQAYVLDRHLQRCPTGVIGELYISGFGIANGYLGRADLSAARFVANPFEHGQRMYRTGDLVR 872
Cdd:cd17653   250 MTELLPGQPVTIGKPIPNSTCYILDADLQPVPEGVVGEICISGVQVARGYLGNPALTASKFVPDPFWPGSRMYRTGDYGR 329

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490930577  873 WNSAGKLEFMGRCDDQIKIRGYRVEIGEVEN-ALSILTNVESAVVIAepINNshRLLGYCVVKDIELDEKTSEqlsqqyl 951
Cdd:cd17653   330 WTEDGGLEFLGREDNQVKVRGFRINLEEIEEvVLQSQPEVTQAAAIV--VNG--RLVAFVTPETVDVDGLRSE------- 398

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 490930577  952 sqLRQNLPEYMVPSALTVMSEFPRNVSGKVDKKAL 986
Cdd:cd17653   399 --LAKHLPSYAVPDRIIALDSFPLTANGKVDRKAL 431

AMP-binding