|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
5-487 |
0e+00 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 984.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 5 LRHILPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYMLAKWENNTIDVDIPENLNMQSPT 84
Cdd:PRK10815 3 LRHFFPLSLRVRFLLATAAVVLALSLAYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKLSIELPENLDLNSPT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 85 VTLIYDARGQLLWAQRDVPWLVKRIQPDWLKNNGFHEIEADVDSSSMLQHNNHEIQQQLDAIRQEDDGSEMTHSVAINIY 164
Cdd:PRK10815 83 LVLIYDENGKLLWRQRDVPWLEKMIQPEWLKKNGFHEIETDVNDSSLLLSGDHSAQQQLKEVREDDDDAEMTHSVAVNVY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 165 PATSTMPQLSIVVVDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREMLNPNTT 244
Cdd:PRK10815 163 PATSRLPKLTIVVVDTIPQELQRSYMVWSWFSYVLLANLLLVIPLLWLAAWWSLRPIEALAKQVRELEEGEREQLDPNPP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 245 RELTRLVSNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRGEK-MSVNEAEPVMLEQISRISQQIGYYLH 323
Cdd:PRK10815 243 RELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVLQSTLRSLRSGKqMSVEQAEPIMLEQISRISQQIGYYLH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 324 RASMRSGGSLLSRELHPIAPLLDSLTSALNKVYQRKGVNITLDISPEISFVGEKNDFMEVMGNVLDNACKYCLEFVEVSV 403
Cdd:PRK10815 323 RASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISA 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 404 RQTnDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLRPGQGVGLSVARDIVAQYDGRILAEESLLGGACMEVIFGRQAL 483
Cdd:PRK10815 403 RQT-DEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGRQHS 481
|
....
gi 490988238 484 EDKE 487
Cdd:PRK10815 482 TPKD 485
|
|
| PhoQ_Sensor |
pfam08918 |
PhoQ Sensor; The PhoQ Sensor is required for the virulence of various Gram-negative bacteria ... |
10-189 |
5.90e-113 |
|
PhoQ Sensor; The PhoQ Sensor is required for the virulence of various Gram-negative bacteria by allowing interaction of PhoPQ with the intracellular membrane, resulting in remodelling of the bacterial cell surface and subsequent bacterial resistance to host antimicrobial peptides. The domain contains a major flat acidic surface, which binds to at least 3 calcium ions, neutralising the domain's negative charge and allowing interaction with the negatively charged membrane. This domain recognizes divalent metal cations, and antimicrobial cationic peptides (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 430316 Cd Length: 179 Bit Score: 330.85 E-value: 5.90e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 10 PLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYMLAKWENNTIDVDIPENLNMQSPTVTLIY 89
Cdd:pfam08918 1 PFSLRTRFLLATAAVVLALSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYSLAQWDDNKLTIAVPPNLDLNSPTLVLIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 90 DARGQLLWAQRDVPWLVKRIQPDWLKNNGFHEIEADVDSSSMLQHNNHEIQQQLDAIRQEDDgSEMTHSVAINIYPATST 169
Cdd:pfam08918 81 DENGKLLWRQRHVPELEKHIKPEWLKKNGFYELDTDTDTSSALLGNNPLAQDQLKAINDDDD-NELTHSVAVNRYPATSR 159
|
170 180
....*....|....*....|
gi 490988238 170 MPQLSIVVVDTIPVELKRSY 189
Cdd:pfam08918 160 LPALTIVVVDTIPQELQRSD 179
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-478 |
3.17e-76 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 235.22 E-value: 3.17e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 343 PLLDSLTSALNKVYQRKGVNITLDISPEISFVGEKNDFMEVMGNVLDNACKYCLEFVEVSVRQTnDNHLHILVEDDGPGI 422
Cdd:cd16954 1 PLLDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQT-DGGLHLIVDDDGPGV 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 490988238 423 PAAMRSAVFDRGQRADTLRPGQGVGLSVARDIVAQYDGRILAEESLLGGACMEVIF 478
Cdd:cd16954 80 PESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
159-478 |
5.52e-38 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 141.58 E-value: 5.52e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 159 VAINIYPATSTMPQLSIVVVDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREM 238
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 239 LNPNTTRELTRLVSNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRGEKMS-VNEAEPVMLEQISRISQQ 317
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEeQREYLETILRSADRLLRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 318 IGYYLHRASMRSGGSLLSRELHPIAPLLDSLTSALNKVYQRKGVNITLDISPEISFV-GEKNDFMEVMGNVLDNACKYCL 396
Cdd:COG0642 161 INDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVrGDPDRLRQVLLNLLSNAIKYTP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 397 E--FVEVSVRQTNDnHLHILVEDDGPGIPAAMRSAVFDRGQRADTLRPGQGV--GLSVARDIVAQYDGRILAEESLLGGA 472
Cdd:COG0642 241 EggTVTVSVRREGD-RVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTglGLAIVKRIVELHGGTIEVESEPGKGT 319
|
....*.
gi 490988238 473 CMEVIF 478
Cdd:COG0642 320 TFTVTL 325
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
249-478 |
2.87e-37 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 136.96 E-value: 2.87e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 249 RLVSNLNRLLKSERERydkyRTTLTDLTHSLKTPLAVMQSTLRSMRGEKMSVNEAEPVMLEQIS----RISQQIGYYLHR 324
Cdd:COG2205 1 ELEEALEELEELERLK----SEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIResaeRLLRLIEDLLDL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 325 ASMRSGGSLLSRELHPIAPLLDSLTSALNKVYQRKGVNITLDISPE-ISFVGEKNDFMEVMGNVLDNACKYCLEFVEVSV 403
Cdd:COG2205 77 SRLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITI 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490988238 404 R-QTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLR--PGQGVGLSVARDIVAQYDGRILAEESLLGGACMEVIF 478
Cdd:COG2205 157 SaRREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
139-478 |
8.05e-34 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 131.60 E-value: 8.05e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 139 IQQQLDAIRQEDDGSEMTHSVAINIYPATSTMPQLSIVVVDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSL 218
Cdd:COG5002 32 LLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 219 RPIESLAKEVRELEEHHREMLNPNTTRELTRLVSNLNRLLK---SERERYDKYRTTLT-DLTHSLKTPLAVMQSTLRSMR 294
Cdd:COG5002 112 ILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVErdiTELERLEQMRREFVaNVSHELRTPLTSIRGYLELLL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 295 GEKMSVNEAEP----VMLEQISRISQQIGYYLHRASMRSGGSLLSRELHPIAPLLDSLTSALNKVYQRKGVNITLDISPE 370
Cdd:COG5002 192 DGAADDPEERReyleIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPED 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 371 ISFV-GEKNDFMEVMGNVLDNACKYCLEFVEVSVR-QTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLR----PGQ 444
Cdd:COG5002 272 PLLVlGDPDRLEQVLTNLLDNAIKYTPEGGTITVSlREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRsretGGT 351
|
330 340 350
....*....|....*....|....*....|....
gi 490988238 445 GVGLSVARDIVAQYDGRILAEESLLGGACMEVIF 478
Cdd:COG5002 352 GLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
375-478 |
3.76e-23 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 93.87 E-value: 3.76e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 375 GEKNDFMEVMGNVLDNACKYCLEFVEVSVR-QTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRAD---TLRPGQGVGLSV 450
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTlERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsRKIGGTGLGLSI 80
|
90 100
....*....|....*....|....*...
gi 490988238 451 ARDIVAQYDGRILAEESLLGGACMEVIF 478
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITL 108
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
193-478 |
9.38e-23 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 100.86 E-value: 9.38e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 193 SWFIYVLAAnlLLVIPLLWVAAWWSLRPIESLakevreLEEHHREMLNPNTTR-------ELTRLVSNLNRLL----KSE 261
Cdd:PRK10549 166 SWLIVALST--LLAALATFLLARGLLAPVKRL------VEGTHKLAAGDFTTRvtptsrdELGRLAQDFNQLAstleKNE 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 262 RERydkyRTTLTDLTHSLKTPLAVMQSTLRSMR-GEKMSVNEAEPVMLEQISRISQQIGYyLHRASMRSGGSLLSRELH- 339
Cdd:PRK10549 238 QMR----RDFMADISHELRTPLAVLRGELEAIQdGVRKFTPESVASLQAEVGTLTKLVDD-LHQLSLSDEGALAYRKTPv 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 340 PIAPLLDSLTSALNKVYQRKGVNITLDISPEISFVGEKNDFMEVMGNVLDNACKYCLE--FVEVSVRQTnDNHLHILVED 417
Cdd:PRK10549 313 DLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSggSLHISAEQR-DKTLRLTFAD 391
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490988238 418 DGPGIPAAMRSAVFDRGQRADTLRP----GQGVGLSVARDIVAQYDGRILAEESLLGGACMEVIF 478
Cdd:PRK10549 392 SAPGVSDEQLQKLFERFYRTEGSRNrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 456
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
236-476 |
2.09e-22 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 100.88 E-value: 2.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 236 REMLNPNTTREL---TRLVSN-LNRL----------LKSERERYdkyRTTL-TDLTHSLKTPLAVMqstlrsmrgekmsV 300
Cdd:PRK10490 620 RQLMIPEQQRLLetfTLLIANaLERLtltaseeqarLASEREQL---RNALlAALSHDLRTPLTVL-------------F 683
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 301 NEAEPVML----------EQISRISQQI-------GYYLHRASMRSGGSLLSRELHPIAPLLDSLTSALNkvYQRKGVNI 363
Cdd:PRK10490 684 GQAEILTLdlasegsphaRQASEIRQQVlnttrlvNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLE--PGLSGHPI 761
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 364 TLDISPEISFVGEKNDFME-VMGNVLDNACKYCLEFVEVSVR-QTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRAD--T 439
Cdd:PRK10490 762 NLSLPEPLTLIHVDGPLFErVLINLLENAVKYAGAQAEIGIDaHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNkeS 841
|
250 260 270
....*....|....*....|....*....|....*..
gi 490988238 440 LRPGQGVGLSVARDIVAQYDGRILAEESLLGGACMEV 476
Cdd:PRK10490 842 AIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRV 878
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
380-478 |
3.17e-22 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 91.13 E-value: 3.17e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 380 FMEVMGNVLDNACKYCLEF--VEVSVRQTNDnHLHILVEDDGPGIPAAMRSAVFDRGQRADTLR--PGQGVGLSVARDIV 455
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGgtIEISLRQEGD-GVVLEVEDNGPGIPEEDLERIFERFYRGDKSRegGGTGLGLAIVRRIV 79
|
90 100
....*....|....*....|...
gi 490988238 456 AQYDGRILAEESLLGGACMEVIF 478
Cdd:cd00075 80 EAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
375-478 |
7.63e-21 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 87.42 E-value: 7.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 375 GEKNDFMEVMGNVLDNACKYCLEFVEVSVRQTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLR-PGQGVGLSVARD 453
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGgGGTGLGLSIVRK 80
|
90 100
....*....|....*....|....*
gi 490988238 454 IVAQYDGRILAEESLLGGACMEVIF 478
Cdd:pfam02518 81 LVELLGGTITVESEPGGGTTVTLTL 105
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
199-476 |
1.56e-18 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 88.07 E-value: 1.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 199 LAANLLLVIPLLWVAAWWSLRPIESL---AKEV--------RELEEHHREMLNpnTTRELTRLVSNLNRLLkSERERYdk 267
Cdd:PRK09470 172 LLVTMLVSTPLLLWLAWSLAKPARKLknaADEVaqgnlrqhPELETGPQEFRQ--AGASFNQMVTALERMM-TSQQRL-- 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 268 yrttLTDLTHSLKTPLAVMQ---STLRSMRGEKmsvNEAEPVMLEqISRISQQIGYYLHRASMRSGgSLLSRELHPIAPL 344
Cdd:PRK09470 247 ----LSDISHELRTPLTRLQlatALLRRRQGES---KELERIETE-AQRLDSMINDLLVLSRNQQK-NHLERETFKANSL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 345 L-DSLTSALNKVYQRkgvNITLDIS--PEISFV-GEKNDFMEVMGNVLDNACKYCLEFVEVSVrQTNDNHLHILVEDDGP 420
Cdd:PRK09470 318 WsEVLEDAKFEAEQM---GKSLTVSapPGPWPInGNPNALASALENIVRNALRYSHTKIEVAF-SVDKDGLTITVDDDGP 393
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 421 GIPAAMRSAVFDRGQRADTLRP----GQGVGLSVARDIVAQYDGRILAEESLLGGACMEV 476
Cdd:PRK09470 394 GVPEEEREQIFRPFYRVDEARDresgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTI 453
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
275-478 |
3.16e-18 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 86.55 E-value: 3.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 275 LTHSLKTPLAVMQSTLRSMRGEKMSVNEAEP--------VMLEQISRISQQIGYYLHRASMRSggslLSRELHPIAPLLD 346
Cdd:COG5000 208 IAHEIKNPLTPIQLSAERLRRKLADKLEEDRedleraldTIIRQVDRLKRIVDEFLDFARLPE----PQLEPVDLNELLR 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 347 SLTSALNKVYQRKGVNITLDISPEISFV-GEKNDFMEVMGNVLDNACKYCLEFVEVSVR-QTNDNHLHILVEDDGPGIPA 424
Cdd:COG5000 284 EVLALYEPALKEKDIRLELDLDPDLPEVlADRDQLEQVLINLLKNAIEAIEEGGEIEVStRREDGRVRIEVSDNGPGIPE 363
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490988238 425 AMRSAVFDrgqradtlrP-------GQGVGLSVARDIVAQYDGRILAEESLLGGACMEVIF 478
Cdd:COG5000 364 EVLERIFE---------PffttkpkGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
203-478 |
5.83e-18 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 86.05 E-value: 5.83e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 203 LLLVIPLLWVAA--WWSLRPIESLAKEVRELEEHHREMLNPNTTRELTRL---VSNLNRLL--KSERERYdkYRTtltdL 275
Cdd:PRK11100 190 LLLGIALLIGAGvvWWLNRSIRRLTRYADAVTEGKPVPLPKLGSSELRELaqaLESMRVKLegKAYVEQY--VQT----L 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 276 THSLKTPLAvmqstlrSMRG------EKMSVNEAEPVM---LEQISRISQQIGYYLHRASMRSGGSLLSRELHPIAPLLD 346
Cdd:PRK11100 264 THELKSPLA-------AIRGaaellqEDPPPEDRARFTgniLTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLE 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 347 SLTSALNKVYQRKGVNITLDIsPEISFVGEKNDFMEVMGNVLDNAckycLEF------VEVSVRQTNDnHLHILVEDDGP 420
Cdd:PRK11100 337 ELVEAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNA----IDFspeggtITLSAEVDGE-QVALSVEDQGP 410
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490988238 421 GIPAAMRSAVFDRG---QRADTLRPGQGVGLSVARDIVAQYDGRILAEESLLGGACMEVIF 478
Cdd:PRK11100 411 GIPDYALPRIFERFyslPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
332-478 |
2.50e-17 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 83.74 E-value: 2.50e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 332 SLLSRELHPIA-PLLDSLTSALNKVYQRKGVNITLDISPEISFVGEK-NDFMEVMGNVLDNACKYCLE------FVEVSV 403
Cdd:COG3290 232 ELIDSLLSRIGnPVLAALLLGKAARARERGIDLTIDIDSDLPDLPLSdTDLVTILGNLLDNAIEAVEKlpeeerRVELSI 311
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490988238 404 RQTNDnHLHILVEDDGPGIPAAMRSAVFDRGQRadT-LRPGQGVGLSVARDIVAQYDGRILAEESLLGGACMEVIF 478
Cdd:COG3290 312 RDDGD-ELVIEVEDSGPGIPEELLEKIFERGFS--TkLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
384-477 |
2.66e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 77.37 E-value: 2.66e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 384 MGNVLDNACKYCLEFVEVSVRQTNDnHLHILVEDDGPGIPAAMRSAVFDRGQRADTLR----PGQGVGLSVARDIVAQYD 459
Cdd:cd16949 5 LENVLRNALRYSPSKILLDISQDGD-QWTITITDDGPGVPEDQLEQIFLPFYRVDSARdresGGTGLGLAIAERAIEQHG 83
|
90
....*....|....*...
gi 490988238 460 GRILAEESLLGGACMEVI 477
Cdd:cd16949 84 GKIKASNRKPGGLRVRIW 101
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-473 |
6.50e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 76.31 E-value: 6.50e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 383 VMGNVLDNACKYCLEFVEVSVRqTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLR----PGQGVGLSVARDIVAQY 458
Cdd:cd16939 4 ALDNLLRNALRYAHRTVRIALL-VSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRdratGGFGLGLAIVHRVALWH 82
|
90
....*....|....*
gi 490988238 459 DGRILAEESLLGGAC 473
Cdd:cd16939 83 GGHVECDDSELGGAC 97
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
191-478 |
1.08e-16 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 81.38 E-value: 1.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 191 VWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREmlnpnttRELTRlvsnlNRLLKSERerydkyRT 270
Cdd:COG4191 79 LLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEE-------LRELQ-----EQLVQSEK------LA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 271 TLTDLT----HSLKTPLAVMQSTLRSMRgEKMSVNEAEPVMLEQISRISQQIgyylHRA-----SMR--SGGSLLSRELH 339
Cdd:COG4191 141 ALGELAagiaHEINNPLAAILGNAELLR-RRLEDEPDPEELREALERILEGA----ERAaeivrSLRafSRRDEEEREPV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 340 PIAPLLDSLTSALNKVYQRKGVNITLDISPEISFV-GEKNDFMEVMGNVLDNACkYCLE-----FVEVSVRQTnDNHLHI 413
Cdd:COG4191 216 DLNELIDEALELLRPRLKARGIEVELDLPPDLPPVlGDPGQLEQVLLNLLINAI-DAMEegeggRITISTRRE-GDYVVI 293
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490988238 414 LVEDDGPGIPAAMRSAVFD-------RGQradtlrpGQGVGLSVARDIVAQYDGRILAEESLLGGACMEVIF 478
Cdd:COG4191 294 SVRDNGPGIPPEVLERIFEpffttkpVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
190-473 |
3.29e-15 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 77.34 E-value: 3.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 190 MVWSWFIYVLAANLLLVIP-LLWVAAWW-SLRPIESLAKEVRE--LEEhhREMLNPNTT-----RELTRLVSNLNRLLKS 260
Cdd:PRK10604 134 MRLLDIALLALIGLSLAFPvFLWMRPHWqDMLKLEAAAQRLGDghLAE--RIHFDEGSSlerlgVAFNQMADNINALIAS 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 261 ererydkyRTTLTD-LTHSLKTPLAVMQSTLrsmrgeKMSVN--EAEPVMLEQ-ISRISQQIGYYLHRASmrsggslLSR 336
Cdd:PRK10604 212 --------KKQLIDgIAHELRTPLVRLRYRL------EMSDNlsAAESQALNRdIGQLEALIEELLTYAR-------LDR 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 337 ---ELHPIAPLLDS-LTSALNKVYQ-RKGVNITLDISPEISFVGEKNDFME-VMGNVLDNACKYCLEFVEVSVrQTNDNH 410
Cdd:PRK10604 271 pqnELHLSEPDLPAwLSTHLADIQAvTPEKTVRLDTPHQGDYGALDMRLMErVLDNLLNNALRYAHSRVRVSL-LLDGNQ 349
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490988238 411 LHILVEDDGPGIPAAMRSAVFDRGQRADTLRP----GQGVGLSVARDIVAQYDGRILAEESLLGGAC 473
Cdd:PRK10604 350 ACLIVEDDGPGIPPEERERVFEPFVRLDPSRDratgGCGLGLAIVHSIALAMGGSVNCDESELGGAR 416
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
4-478 |
4.65e-15 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 77.52 E-value: 4.65e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 4 VLRHILPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYMLAKWENNTIDVDIPENLNMQSP 83
Cdd:COG4251 25 LLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 84 TVTLIYDARGQLLWAQRDVPWLVKRIQPDWLKNNGFHEIEADVDSSSMLQHNNHEIQQQLDAIRQEDDGSEMTHSVAINI 163
Cdd:COG4251 105 ALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 164 YPATSTMPQLSIVVVDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREMLNPNT 243
Cdd:COG4251 185 LLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEEL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 244 TRELTRLVSNLNRllkSERErydkyrttLTDLTHS----LKTPLAVMQS---TLRSMRGEKMSvneaePVMLEQISRISQ 316
Cdd:COG4251 265 EEELEERTAELER---SNEE--------LEQFAYVashdLREPLRKISGfsqLLEEDYGDKLD-----EEGREYLERIRD 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 317 QIgyylHRASM---------RSGGSLLSRELHPIAPLLDSLTSALNKVYQRKGVNITLDISPEIsfVGEKNDFMEVMGNV 387
Cdd:COG4251 329 AA----ERMQAliddllaysRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTV--RGDPTLLRQVFQNL 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 388 LDNACKYCLE----FVEVSVRQTNDNHlHILVEDDGPGIPAAMRSAVFDRGQR--ADTLRPGQGVGLSVARDIVAQYDGR 461
Cdd:COG4251 403 ISNAIKYSRPgeppRIEIGAEREGGEW-VFSVRDNGIGIDPEYAEKIFEIFQRlhSRDEYEGTGIGLAIVKKIVERHGGR 481
|
490
....*....|....*..
gi 490988238 462 ILAEESLLGGACMEVIF 478
Cdd:COG4251 482 IWVESEPGEGATFYFTL 498
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-471 |
3.36e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 65.89 E-value: 3.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 382 EVMGNVLDNACKYCLEFVEVSVRQTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRAD-TLRPGQGVGLSVARDIVAQYDG 460
Cdd:cd16940 16 LLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSDgQNYGGSGLGLSIVKRIVELHGG 95
|
90
....*....|.
gi 490988238 461 RILAEESLLGG 471
Cdd:cd16940 96 QIFLGNAQGGG 106
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
380-471 |
5.87e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 65.18 E-value: 5.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 380 FMEVMGNVLDNACKYCLE--FVEVSVRQTnDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLRP----GQGVGLSVARD 453
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTggKLRIRAAQT-PQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasgGSGLGLAICHN 83
|
90
....*....|....*...
gi 490988238 454 IVAQYDGRILAEESLLGG 471
Cdd:cd16946 84 IALAHGGTISAEHSPLGG 101
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
228-473 |
9.67e-13 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 69.59 E-value: 9.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 228 VRELEEHHREMLNPNT--TRELTRLVSNLNRLlKSERErydkyrtTLTD-----------LTHSLKTPL-----AVmqST 289
Cdd:PRK09303 106 YSGLGENLQPSEIDSGrySQELLQLSDELFVL-RQENE-------TLLEqlkfkdrvlamLAHDLRTPLtaaslAL--ET 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 290 LRSmrGEKMSVNEAEPVMLEQ-----------ISRISQQIgyyLHRASMRSGgsllSRELHP----IAPLLDSLTSALNK 354
Cdd:PRK09303 176 LEL--GQIDEDTELKPALIEQlqdqarrqleeIERLITDL---LEVGRTRWE----ALRFNPqkldLGSLCQEVILELEK 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 355 VYQRKGVNITLDISPEISFVGEKNDFM-EVMGNVLDNACKYCLEFVEVSVrqtndNHLH-------ILVEDDGPGIPAAM 426
Cdd:PRK09303 247 RWLAKSLEIQTDIPSDLPSVYADQERIrQVLLNLLDNAIKYTPEGGTITL-----SMLHrttqkvqVSICDTGPGIPEEE 321
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 490988238 427 RSAVFD---RGQRADTlRPGQGVGLSVARDIVAQYDGRILAEESLLGGAC 473
Cdd:PRK09303 322 QERIFEdrvRLPRDEG-TEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSC 370
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-476 |
1.79e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 63.46 E-value: 1.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 383 VMGNVLDNACKYCLEF------VEVSVRQTNDNhLHILVEDDGPGIPAAMRSAVFDRG--QRADTLRpgqGVGLSVARDI 454
Cdd:cd16915 4 IVGNLIDNALDALAATgapnkqVEVFLRDEGDD-LVIEVRDTGPGIAPELRDKVFERGvsTKGQGER---GIGLALVRQS 79
|
90 100
....*....|....*....|..
gi 490988238 455 VAQYDGRILAEESLLGGACMEV 476
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSI 101
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
199-465 |
5.14e-12 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 67.30 E-value: 5.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 199 LAANLLLVIPLLWVAAW---WSLRPIESLAKEvreLEEHHREMLNP----NTTRELTRLVSNLNRLLKSERERYDKYRTT 271
Cdd:PRK10755 64 LVPSLVMVSLTLLICFQavrWITRPLAELQKE---LEARTADNLTPiaihSSTLEIEAVTSALNQLVSRLTSTLDQERLF 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 272 LTDLTHSLKTPLAVMQSTLRSMrgEKMSVNEAEPVmleqISRISQQIG-----YYLHRA--SMRSGG----SLLSrelHP 340
Cdd:PRK10755 141 TADVAHELRTPLAGIRLHLELL--EKQHHIDVAPL----IARLDQMMHtveqlLQLARAgqSFSSGHyqtvKLLE---DV 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 341 IAPLLDSLTSALnkvyQRKGVNITLDISP-EISFVGEKNDFMEVMGNVLDNACKYCLEFVEVSVRQTNDNH-LHILVEDD 418
Cdd:PRK10755 212 ILPSQDELSEML----EQRQQTLLLPESAaDITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGgAVLAVEDE 287
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 490988238 419 GPGIPAAMRSAVFDRGQRADTLRPGQGVGLSVARDIVAQYDGRILAE 465
Cdd:PRK10755 288 GPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLQ 334
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
40-478 |
9.05e-12 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 66.97 E-value: 9.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 40 YSVSFDKTTFRLLRGESNLFYMLAKWENNTIDVDIPENLNMQSPTVTLIYDARGQLLWAQRDVPWLVKRIQPDWLKNNGF 119
Cdd:COG2972 4 SLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLIL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 120 HEIEADVDSSSMLQHNNHEIQQQLDAIRQEDDGSEMTHSVAINIYPATSTMPQLSIVVVDTIPVELKRSYMVWSWFIYVL 199
Cdd:COG2972 84 LLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLII 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 200 AANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREMLNPNTTRELTRLVSNLNRLLkserERYDKYRTTLTDLTHSL 279
Cdd:COG2972 164 LLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSGNDEIGILARSFNEMV----ERIKELIEEVYELELEK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 280 K-TPLAVMQS---------TLRSMRgekMSVNEAEPvmlEQISRISQQIGYYLhRASMRSGGSL--LSRELHPIAPLLds 347
Cdd:COG2972 240 KeAELKALQAqinphflfnTLNSIR---WLAELEDP---EEAEEMLEALSKLL-RYSLSKGDELvtLEEELELIKSYL-- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 348 ltsALNKVYQRKGVNITLDISPEIsfvgekndfMEVM------GNVLDNACKYCLE------FVEVSVRQTNDnHLHILV 415
Cdd:COG2972 311 ---EIQKLRFGDRLEVEIEIDEEL---------LDLLipklilQPLVENAIEHGIEpkegggTIRISIRKEGD-RLVITV 377
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490988238 416 EDDGPGIPAAMRSAVFdrgQRADTLRPGQGVGLSVARDIVAQYDG---RILAEESLLGGACMEVIF 478
Cdd:COG2972 378 EDNGVGMPEEKLEKLL---EELSSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRI 440
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-476 |
1.27e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 60.93 E-value: 1.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 383 VMGNVLDNACKYCLEFVEVSvRQTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLR--PGQGVGLSVARDIVAQYDG 460
Cdd:cd16950 4 VLSNLVDNALRYGGGWVEVS-SDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARgtSGTGLGLAIVQRISDAHGG 82
|
90
....*....|....*.
gi 490988238 461 RILAEESLLGGACMEV 476
Cdd:cd16950 83 SLTLANRAGGGLCARI 98
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
219-473 |
1.50e-11 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 66.85 E-value: 1.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 219 RPIESLAKEVRELEeHHREMLNPNT---TRELTRLVSNlNRLLKSERERYDKYRTT-LTDLTHSLKTPLAVMQSTLRSMR 294
Cdd:PRK11466 393 RLMDAFRSNVHALN-RHREQLAAQVkarTAELQELVIE-HRQARAEAEKASQAKSAfLAAMSHEIRTPLYGILGTAQLLA 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 295 GEKMSVNEAEPVML-----EQISRISQQIgyyLHRASMRSGGSLLSRELHPIAP--LLDSLTSALNKVYQRKGVNITLDI 367
Cdd:PRK11466 471 DNPALNAQRDDLRAitdsgESLLTILNDI---LDYSAIEAGGKNVSVSDEPFEPrpLLESTLQLMSGRVKGRPIRLATDI 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 368 SPEI--SFVGEKNDFMEVMGNVLDNACKYCLEFVEVSVRQTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLRPGQG 445
Cdd:PRK11466 548 ADDLptALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGTG 627
|
250 260
....*....|....*....|....*...
gi 490988238 446 VGLSVARDIVAQYDGRILAEESLLGGAC 473
Cdd:PRK11466 628 LGLTISSRLAQAMGGELSATSTPEVGSC 655
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
150-462 |
4.32e-11 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 64.79 E-value: 4.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 150 DDGSEMTHS----VAINIYPATSTMPQLSIVVVDTIPV------ELKRSYMVWSWFIYvlaanlLLVIPLLWVAAWWSLR 219
Cdd:PRK09835 138 HGHGHMEHSnwrmIALPVGPLVDGKPIYTLLIALSIDFhlhyinDLKNKLIMTASVIS------LLIVFIVLLAVHKGHA 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 220 PIESLAKEVRELEEHHREM-LNPNTTR-ELTRLVSNLNRLLKSERERYDKYRTTLTDLTHSLKTPLA--VMQS--TLRSM 293
Cdd:PRK09835 212 PIRSVSRQIQNITSKDLDVrLDPQTVPiELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITnlITQTeiALSQS 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 294 RGEKmsvnEAEPVM---LEQISRISQQIGYYLHRASMRSggsllsRELHPIAPLLDsLTSALNKVY-------QRKGVNI 363
Cdd:PRK09835 292 RSQK----ELEDVLysnLEELTRMAKMVSDMLFLAQADN------NQLIPEKKMLD-LADEVGKVFdffeawaEERGVEL 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 364 TLDISPeISFVGEKNDFMEVMGNVLDNACKYCLEFVEVSVR-QTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLR- 441
Cdd:PRK09835 361 RFVGDP-CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRcQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRq 439
|
330 340
....*....|....*....|....
gi 490988238 442 ---PGQGVGLSVARDIVAQYDGRI 462
Cdd:PRK09835 440 rkgEGSGIGLAIVKSIVVAHKGTV 463
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-473 |
1.54e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 58.11 E-value: 1.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 381 MEVMGNVLDNACKYCLEF----VEVSVRQTNDNHLhILVEDDGPGIPAAMRSAVFDRGQRADTLR--PGQGVGLSVARDI 454
Cdd:cd16921 2 GQVLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWT-FYVRDNGIGIDPEYAEKVFGIFQRLHSREeyEGTGVGLAIVRKI 80
|
90
....*....|....*....
gi 490988238 455 VAQYDGRILAEESLLGGAC 473
Cdd:cd16921 81 IERHGGRIWLESEPGEGTT 99
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
384-462 |
2.78e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 57.47 E-value: 2.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 384 MGNVLDNACKYCLEFVEVSVR-QTNDNHLHILVEDDGPGIPAAMRSAVFDRG---QRADTLRPGQGVGLSVARDIVAQYD 459
Cdd:cd16945 9 INNLLDNAIDFSPEGGLIALQlEADTEGIELLVFDEGSGIPDYALNRVFERFyslPRPHSGQKSTGLGLAFVQEVAQLHG 88
|
...
gi 490988238 460 GRI 462
Cdd:cd16945 89 GRI 91
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
355-478 |
9.29e-10 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 60.75 E-value: 9.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 355 VYQRKGVNITLDISPEISFVGEKNDFME-VMGNVLDNACKYCLEFVEVSVR--QTNDNHLHILVEDDGPGIPAAMRSAVF 431
Cdd:PRK11360 475 AGVQARVDFETELDNELPPIWADPELLKqVLLNILINAVQAISARGKIRIRtwQYSDGQVAVSIEDNGCGIDPELLKKIF 554
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 490988238 432 DrgqRADTLRP-GQGVGLSVARDIVAQYDGRILAEESLLGGACMEVIF 478
Cdd:PRK11360 555 D---PFFTTKAkGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYL 599
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
383-476 |
2.60e-09 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 54.81 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 383 VMGNVLDNACKYCLE--FVEVSVRQTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTL----RPGQGVGLSVARDIVA 456
Cdd:cd16925 8 VVLNLLSNAFKFTPDggRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSstraHGGTGLGLSIVKEFVE 87
|
90 100
....*....|....*....|
gi 490988238 457 QYDGRILAEESLLGGACMEV 476
Cdd:cd16925 88 LHGGTVTVSDAPGGGALFQV 107
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
199-456 |
1.18e-08 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 56.97 E-value: 1.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 199 LAANLLLVIPLLWVAaWWSLRPIESLAKEVRELEEHHREMLNpnTTR---ELTRLVSNLNRLLKS-----ERERydkyRT 270
Cdd:PRK10337 168 LVALPIMLIILMVLL-GRELAPLKKLALALRMRDPDSETPLN--ATGvpsEVRPLVEALNQLFARthammVRER----RF 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 271 TlTDLTHSLKTPLAVM--QSTLRSMRGEKMSVNEAEPVMLEQ-ISRISQQIGYYLHRASMRSGGSLLSRELHPIAPLLDS 347
Cdd:PRK10337 241 T-SDAAHELRSPLAALkvQTEVAQLSDDDPQARKKALLQLHAgIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQS 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 348 LTSALNKVYQRKGVNITLDI-SPEISFVGEKNDFMEVMGNVLDNACKYCLEFVEVSVRQTNDnhlHILVEDDGPGIPAAM 426
Cdd:PRK10337 320 AVMDIYHTAQQAGIDVRLTLnAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR---NFTVRDNGPGVTPEA 396
|
250 260 270
....*....|....*....|....*....|....*
gi 490988238 427 RSAVFDR-----GQRAdtlrPGQGVGLSVARDIVA 456
Cdd:PRK10337 397 LARIGERfyrppGQEA----TGSGLGLSIVRRIAK 427
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
329-478 |
1.88e-08 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 56.01 E-value: 1.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 329 SGGSLLSRELHPIAPLLDSLTSALNKVYqRKGVNITLDISPEISFV-GEKNDFMEVMGNVLDNACKYCLEFVEVSVR--- 404
Cdd:COG3852 194 SRPRPPEREPVNLHEVLERVLELLRAEA-PKNIRIVRDYDPSLPEVlGDPDQLIQVLLNLVRNAAEAMPEGGTITIRtrv 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 405 --------QTNDNHLHILVEDDGPGIPAAMRSAVFD-----RGQradtlrpGQGVGLSVARDIVAQYDGRILAEESLLGG 471
Cdd:COG3852 273 erqvtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEpffttKEK-------GTGLGLAIVQKIVEQHGGTIEVESEPGKG 345
|
....*..
gi 490988238 472 ACMEVIF 478
Cdd:COG3852 346 TTFRIYL 352
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
383-462 |
2.26e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 52.11 E-value: 2.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 383 VMGNVLDNACKYCLE-FVEVSVR----QTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRAD--TLRP--GQGVGLSVARD 453
Cdd:cd16922 4 ILLNLLGNAIKFTEEgEVTLRVSleeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADssTTRKygGTGLGLAISKK 83
|
....*....
gi 490988238 454 IVAQYDGRI 462
Cdd:cd16922 84 LVELMGGDI 92
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-476 |
2.41e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 51.80 E-value: 2.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 382 EVMGNVLDNACKYCL-EFVEVSVRQTND-NHLHILVEDDGPGIPAAMRSAVFDR--GQRADTLRPGQ--GVGLSVARDIV 455
Cdd:cd16953 3 QVLRNLIGNAISFSPpDTGRITVSAMPTgKMVTISVEDEGPGIPQEKLESIFDRfyTERPANEAFGQhsGLGLSISRQII 82
|
90 100
....*....|....*....|....*
gi 490988238 456 AQYDGRILAE----ESLLGGACMEV 476
Cdd:cd16953 83 EAHGGISVAEnhnqPGQVIGARFTV 107
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
362-470 |
6.08e-08 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 54.92 E-value: 6.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 362 NITLDIS-----PEISFVGEKNDFMEVMGNVLDNAckycLEFV------EVSVR-QTNDNHLHILVEDDGPGIPAAMRSA 429
Cdd:PRK11086 411 GITLIISedsqlPDSGDEDQVHELITILGNLIENA----LEAVggeeggEISVSlHYRNGWLHCEVSDDGPGIAPDEIDA 486
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 490988238 430 VFDRGqrADTLRPGQGVGLSVARDIVAQYDGRIlAEESLLG 470
Cdd:PRK11086 487 IFDKG--YSTKGSNRGVGLYLVKQSVENLGGSI-AVESEPG 524
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
271-473 |
6.29e-08 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 55.08 E-value: 6.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 271 TLTDLTHSLKTPLAVMQSTLRS--MRGEKMSVNEAEpvmlEQISRISQQIGYYLH-RASMRSGGSLLSRELHPIaPLLDS 347
Cdd:COG4192 436 TMTSLAHELNQPLNAMSMYLFSakKALEQENYAQLP----TSLDKIEGLIERMDKiIKSLRQFSRKSDTPLQPV-DLRQV 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 348 LTSALNKVYQR-KGVNITLDISPEISFVGEKNDFMEVMGNVLDNACKYCLEFVEVSVRQT-NDNHLHILVEDDGPGIPAA 425
Cdd:COG4192 511 IEQAWELVESRaKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLsNAENLRVAISDNGNGWPLV 590
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 490988238 426 MRsavfdrgqradTLRP-------GQGVGLSVARDIVAQYDGRILAEESLLGGAC 473
Cdd:COG4192 591 DK-----------LFTPftttkevGLGLGLSICRSIMQQFGGDLYLASTLERGAM 634
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
401-476 |
7.03e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 50.47 E-value: 7.03e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490988238 401 VSVRQTNDNHLHILVEDDGPGIPAAMRSAVFDrgQRADTLRPGQGVGLSVARDIVAQYDGRILAEESLLGGACMEV 476
Cdd:cd16920 28 IRTSPADDRAVTISVKDTGPGIAEEVAGQLFD--PFYTTKSEGLGMGLSICRSIIEAHGGRLSVESPAGGGATFQF 101
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-465 |
9.04e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 50.08 E-value: 9.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 383 VMGNVLDNACKYCLE--FVEVSVRQTNDNhLHILVEDDGPGIPAAMRSAVFDRGQRADTLR--PGQGVGLSVARDIVAQY 458
Cdd:cd16923 4 VFSNLLSNAIKYSPEntRIYITSFLTDDV-VNIMFKNPSSHPLDFKLEKLFERFYRGDNSRntEGAGLGLSIAKAIIELH 82
|
....*..
gi 490988238 459 DGRILAE 465
Cdd:cd16923 83 GGSASAE 89
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
383-478 |
1.03e-07 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 54.15 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 383 VMGNVLDNACKYCLEFVEVSVRQTNdNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLR--PGQGVGLSVARDIVAQYDG 460
Cdd:PRK09467 335 ALANLVVNAARYGNGWIKVSSGTEG-KRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARgsSGTGLGLAIVKRIVDQHNG 413
|
90
....*....|....*...
gi 490988238 461 RILAEESLLGGACMEVIF 478
Cdd:PRK09467 414 KVELGNSEEGGLSARAWL 431
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
269-470 |
1.20e-07 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 53.86 E-value: 1.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 269 RTTLTDLTHSLKTPLAVMQSTLRSMRGEKMS---VNEAEPVMLEQISRISQQIGYYLHRASMRSGGSLLSRELHPIAPLL 345
Cdd:PRK11006 205 RNFFANVSHELRTPLTVLQGYLEMMQDQPLEgalREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMML 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 346 DSLTSALNKVYQRKGvNITLDISPEISFVGEKNDFMEVMGNVLDNACKYCLEFVEVSVR-QTNDNHLHILVEDDGPGIPA 424
Cdd:PRK11006 285 RVLEREAQTLSQGKH-TITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRwQRVPQGAEFSVEDNGPGIAP 363
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 490988238 425 AMRSAVFDRGQRADTLRP----GQGVGLSVARDIVAQYDGRiLAEESLLG 470
Cdd:PRK11006 364 EHIPRLTERFYRVDKARSrqtgGSGLGLAIVKHALSHHDSR-LEIESEVG 412
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-477 |
1.60e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 49.38 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 381 MEVMGNVLDNACKYCLEFVEVSVRQTNDNhLHILVEDDGPGIPAAMRSAVFDRGQRADTLRPGQGVGLSVARDIVAQYDG 460
Cdd:cd16976 6 MNLLQNALDAMGKVENPRIRIAARRLGGR-LVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVEEHGG 84
|
90
....*....|....*..
gi 490988238 461 RILAEESLLGGACMEVI 477
Cdd:cd16976 85 RLSVANEEGAGARFTFD 101
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
386-478 |
6.91e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 47.58 E-value: 6.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 386 NVLDNACKYCLEFVEVSVRQTNDNH-LHILVEDDGPGIPAAMRSAVFDRGQRADTLRP----GQGVGLSVARDIVAQYDG 460
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESgARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrntgGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*...
gi 490988238 461 RILAEESLLGGACMEVIF 478
Cdd:cd16952 87 RLLIASELGKGSRFTCLF 104
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-477 |
7.52e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 47.42 E-value: 7.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 382 EVMGNVLDNACKYCLEFVEVSVRQ-TNDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLRPGQGVGLSVARDIVAQYDG 460
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRGRITIRTwAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQKHGG 85
|
90
....*....|....*..
gi 490988238 461 RILAEESLLGGACMEVI 477
Cdd:cd16943 86 TIRVASVPGGGTRFTII 102
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
386-476 |
9.49e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 47.46 E-value: 9.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 386 NVLDNACKYCLEFVEVSVRQTND-NHLHILVEDDGPGIPAAMRSAVFDRGQRADTLRPGQ---GVGLSVARDIVAQYDGR 461
Cdd:cd16975 11 NIISNACQYAPEGGTVSISIYDEeEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGghyGMGLYIAKNLVEKHGGS 90
|
90
....*....|....*
gi 490988238 462 ILAEESLLGGACMEV 476
Cdd:cd16975 91 LIIENSQKGGAEVTV 105
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
277-478 |
2.11e-06 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 49.97 E-value: 2.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 277 HSLKTPLAVMQSTLRSMRGEKMSVNE--AEpVMLEQISRISQQIGYYLhrasmrsggsLLSR------ELHPIAPLLDSL 348
Cdd:COG5809 279 HEIRNPLTSLKGFIQLLKDTIDEEQKtyLD-IMLSELDRIESIISEFL----------VLAKpqaikyEPKDLNTLIEEV 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 349 TSALNKVYQRKGVNITLDISPEISFV-GEKNDFMEVMGNVLDNAckycLEF------VEVSVRQTNDNHLHILVEDDGPG 421
Cdd:COG5809 348 IPLLQPQALLKNVQIELELEDDIPDIlGDENQLKQVFINLLKNA----IEAmpeggnITIETKAEDDDKVVISVTDEGCG 423
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490988238 422 IPAAMRSAVFDrgqradtlrP-------GQGVGLSVARDIVAQYDGRILAEESLLGGACMEVIF 478
Cdd:COG5809 424 IPEERLKKLGE---------PfyttkekGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
277-462 |
2.32e-06 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 50.12 E-value: 2.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 277 HSLKTPLAVMQSTLRSMRGEKMSVNEAEPVMLEQISRISQQIGYYLhrasMRSGGSLLSRELHPIAPLLDSLTSALNKVY 356
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLSELDRIESIISEFL----ALAKPQAVNKEKENINELIQDVVTLLETEA 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 357 QRKGVNITLDISPEISFV-GEKNDFMEVMGNVLDNAckycLEFVE----VSVRQT-NDNHLHILVEDDGPGIPaamrSAV 430
Cdd:COG5805 372 ILHNIQIRLELLDEDPFIyCDENQIKQVFINLIKNA----IEAMPnggtITIHTEeEDNSVIIRVIDEGIGIP----EER 443
|
170 180 190
....*....|....*....|....*....|....
gi 490988238 431 FDR-GQRADTLR-PGQGVGLSVARDIVAQYDGRI 462
Cdd:COG5805 444 LKKlGEPFFTTKeKGTGLGLMVSYKIIENHNGTI 477
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
411-462 |
2.39e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 46.24 E-value: 2.39e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 490988238 411 LHILVEDDGPGIPAAMRSAVFDR--GQRADtlrpGQGVGLSVARDIVAQYDGRI 462
Cdd:cd16918 44 LRVSVIDNGPGIPPDLQDTIFYPmvSGREN----GTGLGLAIAQNIVSQHGGVI 93
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-478 |
4.28e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 45.61 E-value: 4.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 382 EVMGNVLDNACKYCLEF------VEVSVRQTNDNHLHILVEDDGPGIPAAMRSAVFDrgQRADTLRPGQGVGLSVARDIV 455
Cdd:cd16944 7 QVLTNILKNAAEAIEGRpsdvgeVRIRVEADQDGRIVLIVCDNGKGFPREMRHRATE--PYVTTRPKGTGLGLAIVKKIM 84
|
90 100
....*....|....*....|...
gi 490988238 456 AQYDGRILAEESLLGGACMEVIF 478
Cdd:cd16944 85 EEHGGRISLSNREAGGACIRIIL 107
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-462 |
5.19e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 45.58 E-value: 5.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 383 VMGNVLDNACKYCLE--FVEVSVRQtNDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLRP----GQGVGLSVARDIVA 456
Cdd:cd16947 24 ILKNLISNAIKYGSDgkFLGMTLRE-DEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsakqGNGLGLTITKRLAE 102
|
....*.
gi 490988238 457 QYDGRI 462
Cdd:cd16947 103 SMGGSI 108
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
344-467 |
1.32e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 47.52 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 344 LLDSLTSALN----------KVYQRKGVNITLDISP--EISFVGE---KNDFMEVMGNVLDNACKYCLE------FVEVS 402
Cdd:PRK15053 382 LIDSLREAFAdrqvagllfgKVQRARELGLKMVIVPgsQLSQLPPgldSTEFAAIVGNLLDNAFEASLRsdegnkIVELF 461
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490988238 403 VRQTNDNHLhILVEDDGPGIPAAMRSAVFDRGQRADTLRPGQ-GVGLSVARDIVAQYDGRILAEES 467
Cdd:PRK15053 462 LSDEGDDVV-IEVADQGCGVPESLRDKIFEQGVSTRADEPGEhGIGLYLIASYVTRCGGVITLEDN 526
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
275-462 |
1.93e-05 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 46.61 E-value: 1.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 275 LTHSLKTPLAvmqstlrSMRG-----EKM----SVNEAEPVMLEQISRIsqqigyylhRAsmrsggsLLSRELHPIAP-- 343
Cdd:PRK11073 137 LAHEIKNPLG-------GLRGaaqllSKAlpdpALTEYTKVIIEQADRL---------RN-------LVDRLLGPQRPgt 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 344 -LLDSLTSALNKVYQ----RKGVNITL--DISPEISFVGEKNDFME-VMGNVLDNACKYCLE---FVEVSVRQTNDNHLH 412
Cdd:PRK11073 194 hVTESIHKVAERVVQlvslELPDNVRLirDYDPSLPELAHDPDQIEqVLLNIVRNALQALGPeggTITLRTRTAFQLTLH 273
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490988238 413 ---------ILVEDDGPGIPAAMRsavfdrgqraDTL--------RPGQGVGLSVARDIVAQYDGRI 462
Cdd:PRK11073 274 geryrlaarIDIEDNGPGIPPHLQ----------DTLfypmvsgrEGGTGLGLSIARNLIDQHSGKI 330
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
246-474 |
4.06e-05 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 46.17 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 246 ELTRLVSNLNRLLKSERERYD------KYRTT-------------------LTDLTHSLKTPLavmQSTLRSMRGEKMSV 300
Cdd:PRK15347 351 ELGSIAKAYNQLLDTLNEQYDtlenkvAERTQalaeakqraeqankrksehLTTISHEIRTPL---NGVLGALELLQNTP 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 301 NEAEPVMLEQISRISQQ-----IGYYLHRASMRSGGSLLSRELHPIAPLLDSLTSALNKVYQRKGVNITLDISPEISFVG 375
Cdd:PRK15347 428 LTAEQMDLADTARQCTLsllaiINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVPLYL 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 376 EKnDFMEV---MGNVLDNACKYClEFVEVSVR-QTNDNHLHILVEDDGPGIPAAMRSAVFDRGQRADTLRPGQGVGLSVA 451
Cdd:PRK15347 508 HL-DSLRLrqiLVNLLGNAVKFT-ETGGIRLRvKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIA 585
|
250 260
....*....|....*....|...
gi 490988238 452 RDIVAQYDGRILAEESLLGGACM 474
Cdd:PRK15347 586 SSLAKMMGGELTLFSTPGVGSCF 608
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
272-465 |
5.46e-05 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 45.88 E-value: 5.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 272 LTDLTHSLKTPLAVMQSTLRSMRGEKMSVNE-AEPVMLEQISRIS--QQIGYYLHRASMRSGGSLLSRELHPIAPLLDSL 348
Cdd:PRK09959 716 LATMSHEIRTPISSIMGFLELLSGSGLSKEQrVEAISLAYATGQSllGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNT 795
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 349 TSALNKVYQRKGVNITLDIS-PEISFVG-EKNDFMEVMGNVLDNACKYCLE---FVEVSVRQTNDNH--LHILVEDDGPG 421
Cdd:PRK09959 796 CHSFGAIAASKSIALSCSSTfPDHYLVKiDPQAFKQVLSNLLSNALKFTTEgavKITTSLGHIDDNHavIKMTIMDSGSG 875
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 490988238 422 IPAAMRSAVFDRGQRADTLR--PGQGVGLSVARDIVAQYDGRILAE 465
Cdd:PRK09959 876 LSQEEQQQLFKRYSQTSAGRqqTGSGLGLMICKELIKNMQGDLSLE 921
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
272-330 |
4.15e-04 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 38.70 E-value: 4.15e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490988238 272 LTDLTHSLKTPLAVMQSTLRSMRGEKMSVNEAE--PVMLEQISRISQQIGYYLHRASMRSG 330
Cdd:smart00388 6 LANLSHELRTPLTAIRGYLELLLDTELSEEQREylETILREAERLLRLINDLLDLSRIEAG 66
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
190-478 |
4.25e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 41.91 E-value: 4.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 190 MVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREMLnpntTRELTRLvsnlnrllksERERYDkyr 269
Cdd:COG4585 1 LLALALLGALALLVGALLGLLLALVLLRARRAERAAELERELAARAEEAR----EEERRRI----------ARELHD--- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 270 ttltDLTHSLktplAVMQSTLRSMRGEKMSVNEAEPVMLEQISRISQQIGyylhrASMRSggslLSRELHPIAP----LL 345
Cdd:COG4585 64 ----GVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREAL-----AELRR----LVRGLRPPALddlgLA 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 346 DSLTSALNKVYQRKGVNITLDISPEISFVGekndfMEVMGNV-------LDNACKYCL-EFVEVSVRQTnDNHLHILVED 417
Cdd:COG4585 127 AALEELAERLLRAAGIRVELDVDGDPDRLP-----PEVELALyrivqeaLTNALKHAGaTRVTVTLEVD-DGELTLTVRD 200
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490988238 418 DGPGIPAAmrsavfdrgqradtLRPGQGVGLSVARDIVAQYDGRILAEESLLGGACMEVIF 478
Cdd:COG4585 201 DGVGFDPE--------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
382-476 |
5.26e-04 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 42.62 E-value: 5.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 382 EVMGNVLDNACKYCLE-FVEVSVRQTNDNHLHILVEDDGPGIPA-------AMRSAVFDR--GQRAdtlrPGQGVGLSVA 451
Cdd:PRK11091 401 QILWNLISNAVKFTQQgGVTVRVRYEEGDMLTFEVEDSGIGIPEdeldkifAMYYQVKDShgGKPA----TGTGIGLAVS 476
|
90 100
....*....|....*....|....*
gi 490988238 452 RDIVAQYDGRILAEESLLGGACMEV 476
Cdd:PRK11091 477 KRLAQAMGGDITVTSEEGKGSCFTL 501
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-462 |
5.52e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 39.87 E-value: 5.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 345 LDSLTSALNKVYQRKGVNITLDISPEISFVGEKNDFMEVMGNVLDNACKYCLE------FVEVSVRQTNdNHLHILVEDD 418
Cdd:cd16935 2 LDSLLSEKLELAREKGIEFTIEIDIPILLPISPLDLCIIFGNLLDNAIEACAKidkenrFIHLKIRQKK-GFLIISIENS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 490988238 419 GPGIPaamrsaVFDRGQRADTLR-PGQGVGLSVARDIVAQYDGRI 462
Cdd:cd16935 81 YEGEL------KKKNGLFLSTKKdKNHGIGLKSIREIVKKYNGNL 119
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
272-330 |
8.59e-04 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 37.58 E-value: 8.59e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490988238 272 LTDLTHSLKTPLAVMQSTLRSMRGEKMSVNEAE--PVMLEQISRISQQIGYYLHRASMRSG 330
Cdd:pfam00512 6 LANLSHELRTPLTAIRGYLELLRDEKLDEEQREylETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
334-462 |
2.45e-03 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 40.43 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 334 LSRELHPIAPLLdsltsalnKVYQRKGVNITLDISPEISFV-GEKNDFMEVMGNVLDNACKYCLE--FVEVSVRQ----- 405
Cdd:PRK13837 522 LSELVTEIAPLL--------RVSLPPGVELDFDQDQEPAVVeGNPAELQQVLMNLCSNAAQAMDGagRVDISLSRaklra 593
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490988238 406 ---------TNDNHLHILVEDDGPGIPAAMRSAVFDRgqrADTLRP-GQGVGLSVARDIVAQYDGRI 462
Cdd:PRK13837 594 pkvlshgvlPPGRYVLLRVSDTGAGIDEAVLPHIFEP---FFTTRAgGTGLGLATVHGIVSAHAGYI 657
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
340-478 |
3.99e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 39.50 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490988238 340 PIAPLLDSLTSALNKVYQRKGVNITLDIsPEISF-----------VGEkndfmevmgnVLDNACKYCLE-----FVEVSV 403
Cdd:COG3920 360 DLRDYLRELLEPLRDSYGGRGIRIELDG-PDVELpadaavplgliLNE----------LVTNALKHAFLsgeggRIRVSW 428
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490988238 404 RQtNDNHLHILVEDDGPGIPAAMrsavfdrgqradTLRPGQGVGLSVARDIVAQYDGRILAEESllGGACMEVIF 478
Cdd:COG3920 429 RR-EDGRLRLTVSDNGVGLPEDV------------DPPARKGLGLRLIRALVRQLGGTLELDRP--EGTRVRITF 488
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-434 |
4.06e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 36.88 E-value: 4.06e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 490988238 383 VMGNVLDNACKYCLEFVEVSVR-QTNDNHLHILVEDDGPGIPAAMRSAVFDRG 434
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYsETNEQGVVLSIKDFGIGIPEEDLPRVFDKG 61
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
397-448 |
6.61e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 36.28 E-value: 6.61e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 490988238 397 EFVEVSVRQTNDNHLHILVEDDGPGIPAAMRSAVfdrgqRADtLRPGQGVGL 448
Cdd:cd16955 25 GVVKISVKKQLKNRLHIAVEDNGIGISPKVIERV-----EQD-EMPGNKIGL 70
|
|
| |
