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Conserved domains on  [gi|490994072|ref|WP_004855803|]
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MULTISPECIES: FadR/GntR family transcriptional regulator [Klebsiella]

Protein Classification

FadR/GntR family transcriptional regulator( domain architecture ID 11450686)

helix-turn-helix transcriptional regulator belonging to the GntR family, which contains FadR, HutC, MocR, YtrA, AraR, PlmA, and many other subfamilies

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
9-227 9.32e-60

DNA-binding transcriptional regulator, FadR family [Transcription];


:

Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 187.83  E-value: 9.32e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072   9 AAQKNISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPRSSWNFLDk 88
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLD- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  89 eLLAWWLTEDNFSdvVSHFLVMRGSLEPQACFLASTSGTPEQKAQLNALMEEMVELKRNfqRERWIEVDMAWHEHIYEMS 168
Cdd:COG2186   82 -PLALLLALDDAS--LRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADD--GEAFAEADLAFHRAIAEAS 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490994072 169 GNPFLISFASLFHSVYHTYFTSITQNEVVK---LDLHQAIVDAILDSDGLRALSACQALLSA 227
Cdd:COG2186  157 GNPLLALLLESLRELLRRSVRLTLRSPEARersLAEHRAILDAIRAGDPEAARAAMRAHLEA 218
 
Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
9-227 9.32e-60

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 187.83  E-value: 9.32e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072   9 AAQKNISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPRSSWNFLDk 88
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLD- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  89 eLLAWWLTEDNFSdvVSHFLVMRGSLEPQACFLASTSGTPEQKAQLNALMEEMVELKRNfqRERWIEVDMAWHEHIYEMS 168
Cdd:COG2186   82 -PLALLLALDDAS--LRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADD--GEAFAEADLAFHRAIAEAS 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490994072 169 GNPFLISFASLFHSVYHTYFTSITQNEVVK---LDLHQAIVDAILDSDGLRALSACQALLSA 227
Cdd:COG2186  157 GNPLLALLLESLRELLRRSVRLTLRSPEARersLAEHRAILDAIRAGDPEAARAAMRAHLEA 218
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 1-226 1.60e-21

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 89.31  E-value: 1.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072   1 MSLSAQQLAAQKnISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLL----PRPRIgTR 76
Cdd:PRK03837   2 RNLRSRPIARKK-LSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQishgERARV-SR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  77 VMPRSSWNFLD---KELLAwwltedNFSDVVSHFLVMRGSLEPQACFLASTSGTPEQKAQLNALmeemveLKRNFQ---- 149
Cdd:PRK03837  80 PSADTIIGQLSgmaKDFLS------QSPDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKA------LERNSQslgd 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072 150 RERWIEVDMAWHEHIYEMSGNPFLISFA-SLFH--SVYHTYFTSITQNEVVKLDLHQAIVDAILDSDGLRALSACQALLS 226
Cdd:PRK03837 148 NAAFIRSDMEFHRVIAEIPGNPIFMAIHeALLDwlIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLN 227
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 18-77 2.08e-21

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 84.04  E-value: 2.08e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRV 77
Cdd:cd07377    6 IADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 110-225 1.18e-20

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 83.95  E-value: 1.18e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072   110 MRGSLEPQACFLASTSGTPEQKAQLNALMEEMVELKRNF-QRERWIEVDMAWHEHIYEMSGNPFLISFASLFHSVYHTYF 188
Cdd:smart00895   5 VRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGdDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRLR 84

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 490994072   189 TSITQNEVVKLDLHQAIVDAILDSDGLRALSACQALL 225
Cdd:smart00895  85 RLSLEAARRALDEHRAILDAIRARDAEAARAAMREHL 121
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 108-223 2.82e-20

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 82.80  E-value: 2.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  108 LVMRGSLEPQACFLASTSGTPEQKAQLNALMEEMVELKRNFQRERWIEVDMAWHEHIYEMSGNPFLISFASLFHSVYHTY 187
Cdd:pfam07729   3 YELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRRL 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 490994072  188 FTSITQNE---VVKLDLHQAIVDAILDSDGLRALSACQA 223
Cdd:pfam07729  83 RRLLLSSPgrlRASLEEHRAILDAIRARDPEAARAAMRR 121
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 18-80 4.17e-11

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 60.57  E-value: 4.17e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490994072   18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPR 80
Cdd:TIGR02325  13 IADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAAR 75
 
Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
9-227 9.32e-60

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 187.83  E-value: 9.32e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072   9 AAQKNISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPRSSWNFLDk 88
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLD- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  89 eLLAWWLTEDNFSdvVSHFLVMRGSLEPQACFLASTSGTPEQKAQLNALMEEMVELKRNfqRERWIEVDMAWHEHIYEMS 168
Cdd:COG2186   82 -PLALLLALDDAS--LRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADD--GEAFAEADLAFHRAIAEAS 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490994072 169 GNPFLISFASLFHSVYHTYFTSITQNEVVK---LDLHQAIVDAILDSDGLRALSACQALLSA 227
Cdd:COG2186  157 GNPLLALLLESLRELLRRSVRLTLRSPEARersLAEHRAILDAIRAGDPEAARAAMRAHLEA 218
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
19-227 1.00e-35

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 125.81  E-value: 1.00e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  19 AEKLAQKILTGEYQPESILPgEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPrsswnfldkellawwLTED 98
Cdd:COG1802   17 YEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP---------------LSPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  99 NFSDVvshfLVMRGSLEPQACFLASTSGTPEQKAQLNALMEEMVELKRNFQRERWIEVDMAWHEHIYEMSGNPFLISFAS 178
Cdd:COG1802   81 EIREL----YEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLR 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 490994072 179 LFHSVYHTY-FTSITQNEVVK--LDLHQAIVDAILDSDGLRALSACQALLSA 227
Cdd:COG1802  157 RLRARLRRYrRLSLRSPGRLEesLAEHRAILDALEAGDAEAAAAALRAHLER 208
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 1-226 1.60e-21

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 89.31  E-value: 1.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072   1 MSLSAQQLAAQKnISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLL----PRPRIgTR 76
Cdd:PRK03837   2 RNLRSRPIARKK-LSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQishgERARV-SR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  77 VMPRSSWNFLD---KELLAwwltedNFSDVVSHFLVMRGSLEPQACFLASTSGTPEQKAQLNALmeemveLKRNFQ---- 149
Cdd:PRK03837  80 PSADTIIGQLSgmaKDFLS------QSPDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKA------LERNSQslgd 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072 150 RERWIEVDMAWHEHIYEMSGNPFLISFA-SLFH--SVYHTYFTSITQNEVVKLDLHQAIVDAILDSDGLRALSACQALLS 226
Cdd:PRK03837 148 NAAFIRSDMEFHRVIAEIPGNPIFMAIHeALLDwlIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLN 227
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 18-77 2.08e-21

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 84.04  E-value: 2.08e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRV 77
Cdd:cd07377    6 IADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 110-225 1.18e-20

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 83.95  E-value: 1.18e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072   110 MRGSLEPQACFLASTSGTPEQKAQLNALMEEMVELKRNF-QRERWIEVDMAWHEHIYEMSGNPFLISFASLFHSVYHTYF 188
Cdd:smart00895   5 VRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGdDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRLR 84

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 490994072   189 TSITQNEVVKLDLHQAIVDAILDSDGLRALSACQALL 225
Cdd:smart00895  85 RLSLEAARRALDEHRAILDAIRARDAEAARAAMREHL 121
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 108-223 2.82e-20

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 82.80  E-value: 2.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  108 LVMRGSLEPQACFLASTSGTPEQKAQLNALMEEMVELKRNFQRERWIEVDMAWHEHIYEMSGNPFLISFASLFHSVYHTY 187
Cdd:pfam07729   3 YELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRRL 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 490994072  188 FTSITQNE---VVKLDLHQAIVDAILDSDGLRALSACQA 223
Cdd:pfam07729  83 RRLLLSSPgrlRASLEEHRAILDAIRARDPEAARAAMRR 121
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 18-77 4.02e-19

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 78.04  E-value: 4.02e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072   18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRV 77
Cdd:pfam00392   5 VYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
18-80 3.47e-18

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 80.29  E-value: 3.47e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490994072  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPR 80
Cdd:COG2188   10 IADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEP 72
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
18-77 8.29e-18

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 74.53  E-value: 8.29e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072    18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRV 77
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
11-226 4.45e-13

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 66.58  E-value: 4.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  11 QKNISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPRSSWNFLDK-- 88
Cdd:PRK09464   8 QPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSFSDPlv 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  89 ELLAwwltednfSDVVSHF--LVMRGSLEPQACFLASTSGTPEQKAQLNALMEEMVELKRNFQRERWIEVDMAWHEHIYE 166
Cdd:PRK09464  88 ELLS--------DHPESQFdlLETRHALEGIAAYYAALRGTDEDFERIRECHHAIELAQQSGDLDAEANAVMQYQIAVTE 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490994072 167 MSGNPFLI----SFASLFHSvyhtyftSITQN--------EVV-KLDLHQA-IVDAILDSDGLRALSACQALLS 226
Cdd:PRK09464 160 AAHNVVLLhllrCMEPMLEQ-------NVRQNfellyrrrEMLpKVSSHRArIFEAIVAGKPEKAREASHRHLA 226
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 18-80 4.17e-11

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 60.57  E-value: 4.17e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490994072   18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPR 80
Cdd:TIGR02325  13 IADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAAR 75
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 9-185 4.95e-11

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 60.55  E-value: 4.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072   9 AAQKNISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGML------------LPRPRIGTR 76
Cdd:PRK09990   3 DERRPIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIetaqgrgsfvarLNRVQDASP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  77 VM------PRSSWNFLDkellawwltednfsdvvshflvMRGSLEPQACFLASTSGTPEQKAQLNALMEEMVELKRNFQR 150
Cdd:PRK09990  83 LMhlfssqPRTLYDLLE----------------------VRALLEGESARLAALRGTQADFVLITRRYEEMLAAHENNKE 140

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 490994072 151 ERWIE---VDMAWHEHIYEMSGNPFLIS---------FASLFHSV---YH 185
Cdd:PRK09990 141 IDPIEharLDHAFHLAICEASHNPVLVHtlqsltdlmLSSVFASVnnlYH 190
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 18-220 9.40e-11

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 59.78  E-value: 9.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPR-SSWNfldKELLAWWLT 96
Cdd:PRK10421   7 VADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRhETWS---EQNIVQPLK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  97 EDNFSDVVSHFLVM--RGSLEPQACFLASTSGTPEQKAQLNALMEEMveLKRNfqRERWIEVDMAWHEHIYEMSGNPFLI 174
Cdd:PRK10421  84 TLMADDPDYSFDILeaRHAIEASTAWHAAMRATPGDKEKIQLCFEAT--LSED--PDLASQADVRFHLAIAEASHNVVLL 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 490994072 175 S-----FASLFHSVYHTYFTSITQNEVVKL--DLHQAIVDAILDSDGLRALSA 220
Cdd:PRK10421 160 QtmrgfFDVLQSSVKQSRQRMYLVPPVFSQltEQHQAVMDAILAGDAEGARKA 212
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 18-80 4.34e-10

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 58.69  E-value: 4.34e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490994072  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPR 80
Cdd:COG1167   17 LADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAAR 79
PRK11402 PRK11402
transcriptional regulator PhoB;
4-146 3.51e-07

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 49.45  E-value: 3.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072   4 SAQQLAAQkniswvLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPRSsw 83
Cdd:PRK11402   6 SHQLLYAT------VRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQK-- 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490994072  84 nfLDKELLAwwltEDNFSDvvshFLVMRGSlEPQACFLASTSGTPEQKAQ-LNALME-EMVELKR 146
Cdd:PRK11402  78 --VENALLT----VSGFTD----FGVSQGK-ATKEKVIEQERVSAAPFCEkLNIPGNsEVFHLCR 131
PRK09764 PRK09764
GntR family transcriptional regulator;
18-67 1.06e-06

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 47.90  E-value: 1.06e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 490994072  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGML 67
Cdd:PRK09764  10 IADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQIL 59
PRK10225 PRK10225
Uxu operon transcriptional regulator;
21-164 4.95e-06

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 46.17  E-value: 4.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  21 KLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPRSSWNFLDK------------ 88
Cdd:PRK10225  17 MIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTDSpdanvcndagpf 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  89 ELL-AWWLTEDNFSDVVS------HFLVMRGSLEPQACFLASTS-GTPEQ-KAQLNALMEE------MVELKRnfQRERW 153
Cdd:PRK10225  97 ELLqARQLLESNIAEFAAlqatreDIVKMRQALQLEERELASSApGSSESgDMQFHLAIAEathnsmLVELFR--QSWQW 174

                        170
                 ....*....|....
gi 490994072 154 IEVDMAW---HEHI 164
Cdd:PRK10225 175 RENNPMWiqlHSHL 188
PRK14999 PRK14999
histidine utilization repressor; Provisional
 20-77 1.31e-05

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 44.92  E-value: 1.31e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490994072  20 EKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRV 77
Cdd:PRK14999  19 QDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFV 76
PRK11523 PRK11523
transcriptional regulator ExuR;
18-161 3.47e-05

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 43.68  E-value: 3.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPRSSWNFLDKELLAWWLTE 97
Cdd:PRK11523  13 LAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQQAADNNMEFANY 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490994072  98 DNFsdvvsHFLVMRGSLEPQACFLASTSGTPEQKAQLNALMEEmvelKRNFQRERWIEVDMAWH 161
Cdd:PRK11523  93 GPF-----ELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQ----ARGEDCFRDSEWDLQFH 147
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
1-67 4.67e-05

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 43.32  E-value: 4.67e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490994072   1 MSLSAQQLAAqkniswvLAEK-LAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGML 67
Cdd:PRK04984   1 MVIKAQSPAG-------FAEEyIIESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWL 61
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 24-75 1.29e-04

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 42.34  E-value: 1.29e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 490994072  24 QKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGT 75
Cdd:PRK15481  16 QLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGT 67
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 6-80 8.68e-04

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 39.37  E-value: 8.68e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490994072   6 QQLAAQkniswvLAEKLAQKILTGEYqpesiLPGEMELGEQFGVSRTAVREAVKTLAAKGMLLPRPRIGTRVMPR 80
Cdd:PRK10079  15 QEIAAK------LEQELRQHYRCGDY-----LPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMR 78
PRK11414 PRK11414
GntR family transcriptional regulator;
43-173 4.73e-03

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 37.16  E-value: 4.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994072  43 LGEQFGVSRTAVREAVKTLAAKGMLlprprigtRVMPRSSwnFLDKELLAWWLTEDNfsdvvshflVMRGSLEPQACFLA 122
Cdd:PRK11414  40 LAEQLGMSITPVREALLRLVSVNAL--------SVAPAQA--FTVPEVSKRQLDEIN---------RIRYELELMAVALA 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490994072 123 STSGTPEQKAQLNALMEEMVELKRNFQRERWIEVDMAWHEHIYEMSGNPFL 173
Cdd:PRK11414 101 VENLTPQDLAELQELLEKLQQAQEKGDMEQIINANRLFRLAIYHRSNMPIL 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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