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Conserved domains on  [gi|490994290|ref|WP_004856021|]
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MULTISPECIES: DeoR/GlpR family DNA-binding transcription regulator [Klebsiella]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 3-246 3.52e-85

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 253.90  E-value: 3.52e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   3 IYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGAYLTHGASVEPGFQLQSIQMANDKHLIGQKAAEQ 82
Cdd:COG1349   10 ILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKRAIARAAASL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290  83 VEDGDTIIIDCGTTPLALANFI-FDKKIMVITNSIPVVNLLKGRKNIKLIVAPGEYEDASQGMVSFSTADFFRHIHADKV 161
Cdd:COG1349   90 IEDGDTIFLDAGTTTLALARALpDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEALRRFRADKA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290 162 FISTQGVNDLGELTVPEMTDAHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVISQTGLSPDILSLMQTQNVP 241
Cdd:COG1349  170 FLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLEALEEAGVE 249


                 ....*
gi 490994290 242 LLLAD 246
Cdd:COG1349  250 VIVAE 254
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 3-246 3.52e-85

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 253.90  E-value: 3.52e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   3 IYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGAYLTHGASVEPGFQLQSIQMANDKHLIGQKAAEQ 82
Cdd:COG1349   10 ILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKRAIARAAASL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290  83 VEDGDTIIIDCGTTPLALANFI-FDKKIMVITNSIPVVNLLKGRKNIKLIVAPGEYEDASQGMVSFSTADFFRHIHADKV 161
Cdd:COG1349   90 IEDGDTIFLDAGTTTLALARALpDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEALRRFRADKA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290 162 FISTQGVNDLGELTVPEMTDAHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVISQTGLSPDILSLMQTQNVP 241
Cdd:COG1349  170 FLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLEALEEAGVE 249


                 ....*
gi 490994290 242 LLLAD 246
Cdd:COG1349  250 VIVAE 254
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 72-223 1.04e-50

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 163.07  E-value: 1.04e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   72 KHLIGQKAAEQVEDGDTIIIDCGTTPLALANFIFDKK-IMVITNSIPVVNLLKGRKNIKLIVAPGEYEDASQGMVSFSTA 150
Cdd:pfam00455   6 KRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRnLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFVGPLAE 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490994290  151 DFFRHIHADKVFISTQGVNDLGELTVPEMTDAHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVIS 223
Cdd:pfam00455  86 EFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALIT 158
srlR PRK10434
DNA-binding transcriptional repressor;
3-248 2.61e-37

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 131.73  E-value: 2.61e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   3 IYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGAYLTHGASVEPGFQLQSIQMaNDKHLIGQKAAEQ 82
Cdd:PRK10434  10 ILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINT-HKKELIAEAAVSL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290  83 VEDGDTIIIDCGTTPLA----LANFifdKKIMVITNSIPVVNLLKGRKNIKLIVAP-GEYEDASQGMVSFSTADFFRHIH 157
Cdd:PRK10434  89 IHDGDSIILDAGSTVLQmvplLSRF---NNITVMTNSLHIVNALSELDNEQTILMPgGTFRKKSASFHGQLAENAFEHFT 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290 158 ADKVFISTQGVN-DLGELTVPEMTdaHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVISQTGLSPDILSLMQ 236
Cdd:PRK10434 166 FDKLFIGTDGIDlNAGVTTFNEVY--TVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAFRQALE 243

                        250
                 ....*....|..
gi 490994290 237 TQNVPLLLADSH 248
Cdd:PRK10434 244 EKGIEVIITGES 255
AgaR NF040755
transcriptional repressor AgaR;
1-245 1.06e-35

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 127.39  E-value: 1.06e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   1 MSIYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGAYLTHGAS--VEPGFQLQSIQMANDKHLIGQK 78
Cdd:NF040755   9 EQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALINDGFIpgAEPSVEDKSRLNTAVKRLIAAA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290  79 AAEQVEDGDTIIIDCGTTPLALANFIFDKK-IMVITNSIPVVNLLKGRKNIKLIVAPGEYEDASQgmvSF--STAD-FFR 154
Cdd:NF040755  89 AAELIKPGDRVILDSGTTTYEIARHLKQHQdVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSL---SFygDQAEqSLQ 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290 155 HIHADKVFISTQGVNDLGELTVPEMTDAHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVISQTGLSPDILSL 234
Cdd:NF040755 166 NYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPEEYLQG 245

                        250
                 ....*....|.
gi 490994290 235 MQTQNVPLLLA 245
Cdd:NF040755 246 LRKLGVEVILV 256
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-49 1.51e-11

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 58.00  E-value: 1.51e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 490994290     6 ILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGA 49
Cdd:smart00420   8 LLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGA 51
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 3-246 3.52e-85

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 253.90  E-value: 3.52e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   3 IYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGAYLTHGASVEPGFQLQSIQMANDKHLIGQKAAEQ 82
Cdd:COG1349   10 ILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKRAIARAAASL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290  83 VEDGDTIIIDCGTTPLALANFI-FDKKIMVITNSIPVVNLLKGRKNIKLIVAPGEYEDASQGMVSFSTADFFRHIHADKV 161
Cdd:COG1349   90 IEDGDTIFLDAGTTTLALARALpDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEALRRFRADKA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290 162 FISTQGVNDLGELTVPEMTDAHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVISQTGLSPDILSLMQTQNVP 241
Cdd:COG1349  170 FLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLEALEEAGVE 249


                 ....*
gi 490994290 242 LLLAD 246
Cdd:COG1349  250 VIVAE 254
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 72-223 1.04e-50

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 163.07  E-value: 1.04e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   72 KHLIGQKAAEQVEDGDTIIIDCGTTPLALANFIFDKK-IMVITNSIPVVNLLKGRKNIKLIVAPGEYEDASQGMVSFSTA 150
Cdd:pfam00455   6 KRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRnLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFVGPLAE 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490994290  151 DFFRHIHADKVFISTQGVNDLGELTVPEMTDAHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVIS 223
Cdd:pfam00455  86 EFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALIT 158
srlR PRK10434
DNA-binding transcriptional repressor;
3-248 2.61e-37

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 131.73  E-value: 2.61e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   3 IYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGAYLTHGASVEPGFQLQSIQMaNDKHLIGQKAAEQ 82
Cdd:PRK10434  10 ILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINT-HKKELIAEAAVSL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290  83 VEDGDTIIIDCGTTPLA----LANFifdKKIMVITNSIPVVNLLKGRKNIKLIVAP-GEYEDASQGMVSFSTADFFRHIH 157
Cdd:PRK10434  89 IHDGDSIILDAGSTVLQmvplLSRF---NNITVMTNSLHIVNALSELDNEQTILMPgGTFRKKSASFHGQLAENAFEHFT 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290 158 ADKVFISTQGVN-DLGELTVPEMTdaHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVISQTGLSPDILSLMQ 236
Cdd:PRK10434 166 FDKLFIGTDGIDlNAGVTTFNEVY--TVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAFRQALE 243

                        250
                 ....*....|..
gi 490994290 237 TQNVPLLLADSH 248
Cdd:PRK10434 244 EKGIEVIITGES 255
AgaR NF040755
transcriptional repressor AgaR;
1-245 1.06e-35

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 127.39  E-value: 1.06e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   1 MSIYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGAYLTHGAS--VEPGFQLQSIQMANDKHLIGQK 78
Cdd:NF040755   9 EQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALINDGFIpgAEPSVEDKSRLNTAVKRLIAAA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290  79 AAEQVEDGDTIIIDCGTTPLALANFIFDKK-IMVITNSIPVVNLLKGRKNIKLIVAPGEYEDASQgmvSF--STAD-FFR 154
Cdd:NF040755  89 AAELIKPGDRVILDSGTTTYEIARHLKQHQdVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSL---SFygDQAEqSLQ 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290 155 HIHADKVFISTQGVNDLGELTVPEMTDAHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVISQTGLSPDILSL 234
Cdd:NF040755 166 NYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPEEYLQG 245

                        250
                 ....*....|.
gi 490994290 235 MQTQNVPLLLA 245
Cdd:NF040755 246 LRKLGVEVILV 256
PRK09802 PRK09802
DeoR family transcriptional regulator;
3-245 1.23e-29

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 111.87  E-value: 1.23e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   3 IYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGAYLTHG--ASVEPGFQLQSIQMANDKHLIGQKAA 80
Cdd:PRK09802  22 IIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALICDSttPSVEPSVEDKSALNTAMKRSVAKAAV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290  81 EQVEDGDTIIIDCGTTPLALANFIFD-KKIMVITNSIPVVNLLKGRKNIKLIVAPGEYEDASQGMVSFSTADFFRHIHAD 159
Cdd:PRK09802 102 ELIQPGHRVILDSGTTTFEIARLMRKhTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQSLQNYHFD 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290 160 KVFISTQGVNDLGELTVPEMTDAHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVISQTGLSPDILSLMQTQN 239
Cdd:PRK09802 182 MLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADSLEGLRKAG 261


                 ....*.
gi 490994290 240 VPLLLA 245
Cdd:PRK09802 262 VEVILV 267
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
2-244 3.31e-29

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 110.33  E-value: 3.31e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   2 SIYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGAYLThGASVEPGFQLQSIQMANDKHLIGQKAAE 81
Cdd:PRK10906   9 AIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAALP-SSSVNTPWHDRKATQTEEKERIARKVAS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290  82 QVEDGDTIIIDCGTTPLALANFIFD-KKIMVITNSIPVVNLLKGRKNIKLIVAPGEYEDASQGMVSFSTADFFRHIHADK 160
Cdd:PRK10906  88 QIPNGATLFIDIGTTPEAVAHALLNhSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLDFISQFRLDF 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290 161 VFISTQGVNDLGELTVPEMTDAHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVISQTGLSPDILSLMQTQNV 240
Cdd:PRK10906 168 GILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQLPPASVMQVIEDHHV 247


                 ....
gi 490994290 241 PLLL 244
Cdd:PRK10906 248 QLEL 251
PRK10411 PRK10411
L-fucose operon activator;
3-221 1.10e-24

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 97.95  E-value: 1.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   3 IYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGAYLTHGASVEPG--FQLQSIQMANDKHLIGQKAA 80
Cdd:PRK10411   9 IVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSGdpFHIRLKSHYAHKADIAREAL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290  81 EQVEDGDTIIIDCGTTPLALANFIFDKKIMVITNSIPVVNLLKGRKNIKLIVAPGEYEDASQGMVSFSTADFFRHIHADK 160
Cdd:PRK10411  89 AWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLISQLKSLEIDL 168

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490994290 161 VFISTQGVNDLGELTVPEMTDAHVKQALMRAGRQKILLADSSKFGQTflaGHARLADLDLV 221
Cdd:PRK10411 169 FIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRS---GEARIGHLDEV 226
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
2-245 8.06e-24

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 95.84  E-value: 8.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   2 SIYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGA-YLTHGASVEPGFQLQSIQMANDKHLIGQKAA 80
Cdd:PRK13509   9 ILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGAeAITQQRPRWTPMNIHQAQNHDEKVRIAKAAS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290  81 EQVEDGDTIIIDCGTTPLALANFIFDKKIMVITNSIPVVNLLKGRKNIKLIVAPGEYEDASQgmVSFSTADFFRHIHA-D 159
Cdd:PRK13509  89 QLCNPGESVVINCGSTAFLLGRELCGKPVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQS--ITLSPQGSENSLYAgH 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290 160 KVFISTQGVNDLGeLTVPEMTDAHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVISQTGLSPDILSLMQTQN 239
Cdd:PRK13509 167 WMFTSGKGLTADG-LYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNADPEVLQQLEAQG 245


                 ....*.
gi 490994290 240 VPLLLA 245
Cdd:PRK13509 246 VSILLV 251
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 7-243 1.90e-20

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 87.06  E-value: 1.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290   7 LQQDKKVVVNDLAEKFGVTKMTIRRDLSFfEKQGIVktTYGGAYLTHGASVEPGF-QLQSIQMANDKHLIGQKAAEQVED 85
Cdd:PRK10681  16 LKRSDKLHLKDAAALLGVSEMTIRRDLNA-HSAPVV--LLGGYIVLEPRSASHYLlSDQKSRLVEEKRRAAQLAATLVEP 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290  86 GDTIIIDCGTT-PlalanFIFDKkimvITNSIPVVNL---------LKGRKNIKLIVAPGEYEDASQGMVSFSTADFFRH 155
Cdd:PRK10681  93 NQTLFFDCGTTtP-----WIIEA----IDNELPFTAVcyslntflaLQEKPHCRAILCGGEFHASNAIFKPLDFQQTLDN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490994290 156 IHADKVFISTQGVNDLGELTVPEMTDAHVKQALMRAGRQKILLADSSKFGQTFLAGHARLADLDLVISQTGLSPDILSLM 235
Cdd:PRK10681 164 ICPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMAMAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSDRCPDDEFVKYA 243


                 ....*...
gi 490994290 236 QTQNVPLL 243
Cdd:PRK10681 244 QAQRIKLM 251
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-49 1.51e-11

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 58.00  E-value: 1.51e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 490994290     6 ILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGA 49
Cdd:smart00420   8 LLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGA 51
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
7-49 7.33e-11

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 56.11  E-value: 7.33e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 490994290    7 LQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGA 49
Cdd:pfam08220   9 LKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGA 51
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 1-59 2.11e-04

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 41.60  E-value: 2.11e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490994290   1 MSIYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGI-VKTT---YGGAYLTHGASVEP 59
Cdd:COG2378    8 LALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELGVpIEAErgrGGGYRLRDGYRLPP 70
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 3-41 6.63e-04

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 36.64  E-value: 6.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 490994290    3 IYAILQQDKKVV-VNDLAEKFGVTKMTIRRDLSFFEKQGI 41
Cdd:pfam08279   3 ILQLLLEARGPIsGQELAEKLGVSRRTIRRDIKILEELGV 42
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
3-52 8.67e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 38.26  E-value: 8.67e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490994290   3 IYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQG-IVKTTYGGAYLT 52
Cdd:COG1321   15 IYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGlVEYEPYGGITLT 65
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
15-50 1.62e-03

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 36.01  E-value: 1.62e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 490994290    15 VNDLAEKFGVTKMTIRRDLSFFEKQGIVKTTYGGAY 50
Cdd:smart00345  23 ERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGT 58
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
3-42 3.74e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 34.33  E-value: 3.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 490994290    3 IYAILQQDKKVVVNDLAEKFGVTKMTIRRDLSFFEKQGIV 42
Cdd:pfam13412   6 ILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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