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Conserved domains on  [gi|490996147|ref|WP_004857874|]
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MULTISPECIES: UDP-N-acetylmuramate--L-alanine ligase [Raoultella]

Protein Classification

UDP-N-acetylmuramate--L-alanine ligase( domain architecture ID 11490158)

UDP-N-acetylmuramate--L-alanine ligase catalyzes the addition of the first amino acid to the cytoplasmic precursor of the bacterial cell wall peptidoglycan

CATH:  3.90.190.20|3.40.1190.10
EC:  6.3.2.8
Gene Ontology:  GO:0008763|GO:0009252|GO:0071555|GO:0051301|GO:0007049|GO:0005524|GO:0008360
PubMed:  28201974|16934839
SCOP:  4000154

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 21-476 0e+00

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


:

Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 610.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147   21 HIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLSQLGATIYFNHRPENVRDASVVVVSSAISAENPEIVAAHE 100
Cdd:TIGR01082   1 KIHFVGIGGIGMSGIAEILLNRGYQVSGSDIAENATTKRLEALGIPIYIGHSAENLDDADVVVVSAAIKDDNPEIVEAKE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  101 ARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDA 180
Cdd:TIGR01082  81 RGIPVIRRAEMLAELMRFRHSIAVAGTHGKTTTTAMIAVILKEAGLDPTVVVGGLVKEAGTNARLGSGEYLVAEADESDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  181 SFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQITTYGFS-EDADVR 259
Cdd:TIGR01082 161 SFLHLQPNVAIVTNIEPDHLDTYGSSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKATEQVITYGGSgEDADYR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  260 VEDYRQVGAQGHFRLVRQDKEVLQVTLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQGTGRRFDFLGEYPLaev 339
Cdd:TIGR01082 241 AENIQQSGAEGKFSVRGKGKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEILGEFGG--- 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  340 ngksgsAMLIDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDALLMLDVYSAGEAPIPG 419
Cdd:TIGR01082 318 ------VLLIDDYAHHPTEIKATLKAARQGYPDKRIVVVFQPHRYSRTRDLFDDFAKVLSDADELILLDIYAAGEEPING 391

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 490996147  420 ADSRSLCRTIRGRGKVDPILLSDPAQAAQMLASVLTGNDLILVQGAGNIGKIARHLA 476
Cdd:TIGR01082 392 IDGKSLARKITQLGKIEPYFVPDLAELVEFLAAVLQSGDLILTMGAGDIIKLARELL 448
 
Name Accession Description Interval E-value
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 21-476 0e+00

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 610.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147   21 HIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLSQLGATIYFNHRPENVRDASVVVVSSAISAENPEIVAAHE 100
Cdd:TIGR01082   1 KIHFVGIGGIGMSGIAEILLNRGYQVSGSDIAENATTKRLEALGIPIYIGHSAENLDDADVVVVSAAIKDDNPEIVEAKE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  101 ARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDA 180
Cdd:TIGR01082  81 RGIPVIRRAEMLAELMRFRHSIAVAGTHGKTTTTAMIAVILKEAGLDPTVVVGGLVKEAGTNARLGSGEYLVAEADESDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  181 SFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQITTYGFS-EDADVR 259
Cdd:TIGR01082 161 SFLHLQPNVAIVTNIEPDHLDTYGSSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKATEQVITYGGSgEDADYR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  260 VEDYRQVGAQGHFRLVRQDKEVLQVTLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQGTGRRFDFLGEYPLaev 339
Cdd:TIGR01082 241 AENIQQSGAEGKFSVRGKGKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEILGEFGG--- 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  340 ngksgsAMLIDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDALLMLDVYSAGEAPIPG 419
Cdd:TIGR01082 318 ------VLLIDDYAHHPTEIKATLKAARQGYPDKRIVVVFQPHRYSRTRDLFDDFAKVLSDADELILLDIYAAGEEPING 391

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 490996147  420 ADSRSLCRTIRGRGKVDPILLSDPAQAAQMLASVLTGNDLILVQGAGNIGKIARHLA 476
Cdd:TIGR01082 392 IDGKSLARKITQLGKIEPYFVPDLAELVEFLAAVLQSGDLILTMGAGDIIKLARELL 448
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 16-477 0e+00

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 587.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  16 MRRVRHIHFVgiggagmggiaEVLANEGYQISGSDLAPNPVTQQLSQLGATIYFNHRPENV-------------RDasvv 82
Cdd:COG0773    1 LDKIMHIHFIgiggigmsglaEILLALGYKVSGSDLAESPMTERLEALGIPVFIGHDAENIddadlvvvssaipRD---- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  83 vvssaisaeNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVH 162
Cdd:COG0773   77 ---------NPELVAARERGIPVLSRAEMLAELMRGKRSIAVAGTHGKTTTTSMLAHILEEAGLDPTFLIGGILNNFGTN 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 163 ARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYhGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPR 242
Cdd:COG0773  148 ARLGDGDYFVAEADESDGSFLHYSPDIAVVTNIEADHLDIY-GDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPR 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 243 VGRQITTYGFSEDADVRVEDYRQVGAQGHFRLVRQDKEVLQVTLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQ 322
Cdd:COG0773  227 CGRPVITYGFSEDADYRAENIRIDGGGSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFK 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 323 GTGRRFDFLGEyplaevngkSGSAMLIDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVD 402
Cdd:COG0773  307 GVKRRFELKGE---------VGGVTVIDDYAHHPTEIAATLAAAREKYPDRRLVAVFQPHRYSRTRDFLDEFAEALSLAD 377

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490996147 403 ALLMLDVYSAGEAPIPGADSRSLCRTIRGRGKvDPILLSDPAQAAQMLASVLTGNDLILVQGAGNIGKIARHLAE 477
Cdd:COG0773  378 EVILLDIYAAREKPIPGVSSEDLAEAIRKRGK-DVVYVPDLDELVEALAEIARPGDVVLTMGAGDIGGLGEKLLE 451
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
16-430 3.60e-79

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 262.83  E-value: 3.60e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  16 MRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLSQLGATIYFNHRPENVRDASVVVVSSAISAENPEI 95
Cdd:PRK14573   1 MMKSLFYHFIGIGGIGMSALAHILLDRGYSVSGSDLSEGKTVEKLKAKGARFFLGHQEEHVPEDAVVVYSSSISKDNVEY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  96 VAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLvKAAGVHARLGHSRYLIAEA 175
Cdd:PRK14573  81 LSAKSRGNRLVHRAELLAELMQEQISILVSGSHGKTTVSSLITAIFQEAKKDPSYAIGGL-NQEGLNGYSGSSEYFVAEA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 176 DESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLH-----NLPFYGRavmcvDDPVIRELLprvgrQITTY 250
Cdd:PRK14573 160 DESDGSLKHYTPEFSVITNIDNEHLSNFEGDRELLLASIQDFARkvqqiNKCFYNG-----DCPRLKGCL-----QGHSY 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 251 GFSEDADVRVEDYRQVGAQGHFRLVRQDKEVLQVTLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQGTGRRFdf 330
Cdd:PRK14573 230 GFSSSCDLHILSYYQEGWRSYFSAKFLGVVYQDIELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRL-- 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 331 lgeyplaEVNGKSGSAMLIDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDALLMLDVY 410
Cdd:PRK14573 308 -------ERKNSSETFLFLEDYAHHPSEISCTLRAVRDAVGLRRIIAICQPHRFSRLRECLDSFPSAFQDADEVILTDVY 380

                        410       420
                 ....*....|....*....|
gi 490996147 411 SAGEAPIPGADSRSLCRTIR 430
Cdd:PRK14573 381 SAGEEPEDSISYQKLAEAIS 400
Mur_ligase_M pfam08245
Mur ligase middle domain;
124-295 1.57e-21

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 92.37  E-value: 1.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  124 IAGTHGKTTTTAMVSSIYAEAGLdPTFVNGGLVKAA--------GVHARL-----GHSRYLIAEA-----DESDASFLhL 185
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGG-VIGTIGTYIGKSgnttnnaiGLPLTLaemveAGAEYAVLEVsshglGEGRLSGL-L 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  186 QPMVAIVTNIEADHMDtYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPV---IRELLPRVGRQITTYGFSEDADVRVED 262
Cdd:pfam08245  79 KPDIAVFTNISPDHLD-FHGTMENYAKAKAELFEGLPEDGIAVINADDPYgafLIAKLKKAGVRVITYGIEGEADLRAAN 157

                         170       180       190
                  ....*....|....*....|....*....|...
gi 490996147  263 YRQVGAQGHFRLVRQDKEVLQVTLNAPGRHNAL 295
Cdd:pfam08245 158 IELSSDGTSFDLFTVPGGELEIEIPLLGRHNVY 190
 
Name Accession Description Interval E-value
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 21-476 0e+00

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 610.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147   21 HIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLSQLGATIYFNHRPENVRDASVVVVSSAISAENPEIVAAHE 100
Cdd:TIGR01082   1 KIHFVGIGGIGMSGIAEILLNRGYQVSGSDIAENATTKRLEALGIPIYIGHSAENLDDADVVVVSAAIKDDNPEIVEAKE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  101 ARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDA 180
Cdd:TIGR01082  81 RGIPVIRRAEMLAELMRFRHSIAVAGTHGKTTTTAMIAVILKEAGLDPTVVVGGLVKEAGTNARLGSGEYLVAEADESDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  181 SFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQITTYGFS-EDADVR 259
Cdd:TIGR01082 161 SFLHLQPNVAIVTNIEPDHLDTYGSSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKATEQVITYGGSgEDADYR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  260 VEDYRQVGAQGHFRLVRQDKEVLQVTLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQGTGRRFDFLGEYPLaev 339
Cdd:TIGR01082 241 AENIQQSGAEGKFSVRGKGKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEILGEFGG--- 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  340 ngksgsAMLIDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDALLMLDVYSAGEAPIPG 419
Cdd:TIGR01082 318 ------VLLIDDYAHHPTEIKATLKAARQGYPDKRIVVVFQPHRYSRTRDLFDDFAKVLSDADELILLDIYAAGEEPING 391

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 490996147  420 ADSRSLCRTIRGRGKVDPILLSDPAQAAQMLASVLTGNDLILVQGAGNIGKIARHLA 476
Cdd:TIGR01082 392 IDGKSLARKITQLGKIEPYFVPDLAELVEFLAAVLQSGDLILTMGAGDIIKLARELL 448
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 16-477 0e+00

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 587.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  16 MRRVRHIHFVgiggagmggiaEVLANEGYQISGSDLAPNPVTQQLSQLGATIYFNHRPENV-------------RDasvv 82
Cdd:COG0773    1 LDKIMHIHFIgiggigmsglaEILLALGYKVSGSDLAESPMTERLEALGIPVFIGHDAENIddadlvvvssaipRD---- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  83 vvssaisaeNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVH 162
Cdd:COG0773   77 ---------NPELVAARERGIPVLSRAEMLAELMRGKRSIAVAGTHGKTTTTSMLAHILEEAGLDPTFLIGGILNNFGTN 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 163 ARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYhGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPR 242
Cdd:COG0773  148 ARLGDGDYFVAEADESDGSFLHYSPDIAVVTNIEADHLDIY-GDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPR 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 243 VGRQITTYGFSEDADVRVEDYRQVGAQGHFRLVRQDKEVLQVTLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQ 322
Cdd:COG0773  227 CGRPVITYGFSEDADYRAENIRIDGGGSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFK 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 323 GTGRRFDFLGEyplaevngkSGSAMLIDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVD 402
Cdd:COG0773  307 GVKRRFELKGE---------VGGVTVIDDYAHHPTEIAATLAAAREKYPDRRLVAVFQPHRYSRTRDFLDEFAEALSLAD 377

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490996147 403 ALLMLDVYSAGEAPIPGADSRSLCRTIRGRGKvDPILLSDPAQAAQMLASVLTGNDLILVQGAGNIGKIARHLAE 477
Cdd:COG0773  378 EVILLDIYAAREKPIPGVSSEDLAEAIRKRGK-DVVYVPDLDELVEALAEIARPGDVVLTMGAGDIGGLGEKLLE 451
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
16-430 3.60e-79

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 262.83  E-value: 3.60e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  16 MRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLSQLGATIYFNHRPENVRDASVVVVSSAISAENPEI 95
Cdd:PRK14573   1 MMKSLFYHFIGIGGIGMSALAHILLDRGYSVSGSDLSEGKTVEKLKAKGARFFLGHQEEHVPEDAVVVYSSSISKDNVEY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  96 VAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLvKAAGVHARLGHSRYLIAEA 175
Cdd:PRK14573  81 LSAKSRGNRLVHRAELLAELMQEQISILVSGSHGKTTVSSLITAIFQEAKKDPSYAIGGL-NQEGLNGYSGSSEYFVAEA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 176 DESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLH-----NLPFYGRavmcvDDPVIRELLprvgrQITTY 250
Cdd:PRK14573 160 DESDGSLKHYTPEFSVITNIDNEHLSNFEGDRELLLASIQDFARkvqqiNKCFYNG-----DCPRLKGCL-----QGHSY 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 251 GFSEDADVRVEDYRQVGAQGHFRLVRQDKEVLQVTLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQGTGRRFdf 330
Cdd:PRK14573 230 GFSSSCDLHILSYYQEGWRSYFSAKFLGVVYQDIELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRL-- 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 331 lgeyplaEVNGKSGSAMLIDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDALLMLDVY 410
Cdd:PRK14573 308 -------ERKNSSETFLFLEDYAHHPSEISCTLRAVRDAVGLRRIIAICQPHRFSRLRECLDSFPSAFQDADEVILTDVY 380

                        410       420
                 ....*....|....*....|
gi 490996147 411 SAGEAPIPGADSRSLCRTIR 430
Cdd:PRK14573 381 SAGEEPEDSISYQKLAEAIS 400
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 91-368 7.04e-25

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 106.66  E-value: 7.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147   91 ENPEIVAAHEARIPVIRRAEMLAELMRfRHGIAIAGTHGKTTTTAMVSSIYAEAGLdPTFVNGGLVKAAGVHARLGHSRY 170
Cdd:TIGR01087  75 DHPLVQAAAKRGIPVVGDIELFLRLVP-LPVVAITGTNGKTTTTSLLYHLLKAAGL-KAFLGGNIGTPALEVLDQEGAEL 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  171 LIAEAdesdASF-LH----LQPMVAIVTNIEADHMDtYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGR 245
Cdd:TIGR01087 153 YVLEL----SSFqLEttesLRPEIALILNISEDHLD-WHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKA 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  246 QITTYGFSEDADVRVEdyrqvgaqghfrlVRQDKEVLQV---TLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQ 322
Cdd:TIGR01087 228 QVIWFSVEKDAERGLC-------------IRDGGLYLKPndlEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFK 294

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 490996147  323 GTGRRFDFLGeyplaEVNGKsgsaMLIDDygHHPTEVDATIKAARA 368
Cdd:TIGR01087 295 GLPHRLEYVG-----QKNGV----HFYND--SKATNVHATLAALSA 329
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 91-365 2.44e-23

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 102.08  E-value: 2.44e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  91 ENPEIVAAHEARIPVIrrAEMlaEL-MRFRHG--IAIAGTHGKTTTTAMVSSIYAEAGLDpTFVnGG-----LVKAAgvh 162
Cdd:COG0771   78 DHPLLKAARAAGIPVI--GEI--ELaYRLSPApiIAITGTNGKTTTTTLIGHILKAAGLR-VAV-GGnigtpLLDLL--- 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 163 ARLGHSRYLIAEAdeSdaSF-LH----LQPMVAIVTNIEADHMDtYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIR 237
Cdd:COG0771  149 LEPEPPDVYVLEL--S--SFqLEttpsLRPDVAVILNITPDHLD-RHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTR 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 238 ELLPRVGRQITTYGFSE--DADVRVEDyrqvgaqGHFRLVRQDKEVLQVT-LNAPGRHNAL---------NAAaavavat 305
Cdd:COG0771  224 ALAEEAKARVVPFSLKEplEGGAGLED-------GKLVDRASGEELLPVDdLRLPGRHNLEnalaalaaaRAL------- 289

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490996147 306 eeGIDDSAILRALESFQGTGRRFDFlgeypLAEVNG-------KSgsamliddyghhpTEVDATIKA 365
Cdd:COG0771  290 --GVPPEAIREALRSFKGLPHRLEF-----VAEINGvrfindsKA-------------TNPDATLAA 336
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 122-379 6.49e-23

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 101.31  E-value: 6.49e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 122 IAIAGTHGKTTTTAMVSSIYAEAGLDP-------TFVNGGLVK-------AAGVHArlghsryLIAEADESDASF----- 182
Cdd:COG0769   83 IGVTGTNGKTTTTYLLAQILRALGKKTgligtvgNGIGGELIPsslttpeALDLQR-------LLAEMVDAGVTHvvmev 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 183 ------------LHLQpmVAIVTNIEADHMDtYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQITTY 250
Cdd:COG0769  156 sshaldqgrvdgVRFD--VAVFTNLTRDHLD-YHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRRLAAAAPARVITY 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 251 GFSEDADVRVEDYRQVGAQGHFRLVRQDKEVlQVTLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQGTGRRFDF 330
Cdd:COG0769  233 GLKADADLRATDIELSADGTRFTLVTPGGEV-EVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMER 311

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 490996147 331 LGEyplaevngkSGSAMLIDDYGHHPTEVDATIKAARAgWPDKNLVMLF 379
Cdd:COG0769  312 VDG---------GQGPTVIVDYAHTPDALENVLEALRP-HTKGRLIVVF 350
Mur_ligase_M pfam08245
Mur ligase middle domain;
124-295 1.57e-21

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 92.37  E-value: 1.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  124 IAGTHGKTTTTAMVSSIYAEAGLdPTFVNGGLVKAA--------GVHARL-----GHSRYLIAEA-----DESDASFLhL 185
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGG-VIGTIGTYIGKSgnttnnaiGLPLTLaemveAGAEYAVLEVsshglGEGRLSGL-L 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  186 QPMVAIVTNIEADHMDtYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPV---IRELLPRVGRQITTYGFSEDADVRVED 262
Cdd:pfam08245  79 KPDIAVFTNISPDHLD-FHGTMENYAKAKAELFEGLPEDGIAVINADDPYgafLIAKLKKAGVRVITYGIEGEADLRAAN 157

                         170       180       190
                  ....*....|....*....|....*....|...
gi 490996147  263 YRQVGAQGHFRLVRQDKEVLQVTLNAPGRHNAL 295
Cdd:pfam08245 158 IELSSDGTSFDLFTVPGGELEIEIPLLGRHNVY 190
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 38-365 2.96e-19

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 90.03  E-value: 2.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  38 VLANEGYQISGSDL-APNPVTQQLSQLGA---TIYFNHRPENVRDASVVVVSS-AISAENPEIVAAHEARIPVIRRAEML 112
Cdd:PRK14106  23 FLKKLGAKVILTDEkEEDQLKEALEELGElgiELVLGEYPEEFLEGVDLVVVSpGVPLDSPPVVQAHKKGIEVIGEVELA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 113 AELMRfRHGIAIAGTHGKTTTTAMVSSIYAEAGlDPTFVNGGLvkaaGVHarlghsryLIAEADESDA---------SF- 182
Cdd:PRK14106 103 YRFSK-APIVAITGTNGKTTTTTLLGEIFKNAG-RKTLVAGNI----GYP--------LIDAVEEYGEddiivaevsSFq 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 183 ----LHLQPMVAIVTNIEADHMDTyHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQITTygFSEdadv 258
Cdd:PRK14106 169 letiKEFKPKVGCILNITPDHLDR-HKTMENYIKAKARIFENQRPSDYTVLNYDDPRTRSLAKKAKARVIF--FSR---- 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 259 RVEDYRQVGAQGHFRLVRQD---KEVLQV-TLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQGTGRRFDFLGEY 334
Cdd:PRK14106 242 KSLLEEGVFVKNGKIVISLGgkeEEVIDIdEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEI 321

                        330       340       350
                 ....*....|....*....|....*....|.
gi 490996147 335 plaevngkSGSAMLIDDYGHHPtevDATIKA 365
Cdd:PRK14106 322 --------NGVKFINDSKGTNP---DAAIKA 341
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 122-351 3.16e-17

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 84.00  E-value: 3.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 122 IAIAGTHGKTTTTAMVSSIYAEAGldPTfvngglVKAA-------GVH---ARLGHS-RYLIAEADesdASflHL----- 185
Cdd:COG0770  103 IAITGSNGKTTTKEMLAAVLSTKG--KV------LATPgnfnneiGVPltlLRLPEDhEFAVLEMG---MN--HPgeiay 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 186 -----QPMVAIVTNIEADHMDTYhGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQITTYGFSEDADVRV 260
Cdd:COG0770  170 lariaRPDIAVITNIGPAHLEGF-GSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKARVLTFGLSEDADVRA 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 261 EDYRQVGAQGHFRLVRQDKEVlQVTLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQGTGRRFdflgeyplaEVN 340
Cdd:COG0770  249 EDIELDEDGTRFTLHTPGGEL-EVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRL---------EVI 318

                        250
                 ....*....|.
gi 490996147 341 GKSGSAMLIDD 351
Cdd:COG0770  319 EGAGGVTLIDD 329
Mur_ligase pfam01225
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ...
 21-120 4.37e-15

Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460121 [Multi-domain]  Cd Length: 84  Bit Score: 70.34  E-value: 4.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147   21 HIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNpvtqqLSQLGATIYFNHRPENvrdasvvvvssAISAENPEIVAAHE 100
Cdd:pfam01225   1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIES-----LIALGAAAVVGHDAAN-----------NISPDNPELEAAKV 64

                          90       100
                  ....*....|....*....|
gi 490996147  101 ARIPVIRRAEMLAELMRFRH 120
Cdd:pfam01225  65 PGIPVIDRREALAELAAAFY 84
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 93-365 4.03e-12

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 68.96  E-value: 4.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  93 PEIVAAHEARIPVIRRAEMLAELMRFRHG--------IAIAGTHGKTTTTAMVSSIYAEAG------------LDPTFVN 152
Cdd:PRK11929  78 DQVAAADALVLPVADLRKALGELAARWYGrpseqlslVAVTGTNGKTSCAQLLAQLLTRLGkpcgsigtlgarLDGRLIP 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 153 GGLV--KAAGVHARLGHSRYLIAEADESDAS--------FLHLQPMVAIVTNIEADHMDtYHGDFENLKQTFINFLHNLP 222
Cdd:PRK11929 158 GSLTtpDAIILHRILARMRAAGADAVAMEASshgleqgrLDGLRIAVAGFTNLTRDHLD-YHGTMQDYEEAKAALFSKLP 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 223 FYGRAVMCVDDPVIRELLP--RVGRQITTYGFSEDADVRVEDYRQVGAQGHFRLVRQDKEVlQVTLNAPGRHNALNAAAA 300
Cdd:PRK11929 237 GLGAAVINADDPAAARLLAalPRGLKVGYSPQNAGADVQARDLRATAHGQVFTLATPDGSY-QLVTRLLGRFNVSNLLLV 315

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490996147 301 VAVATEEGIDDSAILRALESFQGTGRRFDFLGEYPlaevnGKSGSAMLIdDYGHHPtevDATIKA 365
Cdd:PRK11929 316 AAALKKLGLPLAQIARALAAVSPVPGRMERVGPTA-----GAQGPLVVV-DYAHTP---DALAKA 371
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 122-368 1.51e-11

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 66.19  E-value: 1.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  122 IAIAGTHGKTTTTAMVSSIYAEAGLDPTFV-------NGGLVKAAGVH---------------ARLGHSRYLIAEAdESD 179
Cdd:TIGR01085  88 IGVTGTNGKTTTTSLIAQLLRLLGKKTGLIgtigyrlGGNDLIKNPAAlttpealtlqstlaeMVEAGAQYAVMEV-SSH 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  180 ASFLH-LQPM---VAIVTNIEADHMDtYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQITTYGFSED 255
Cdd:TIGR01085 167 ALAQGrVRGVrfdAAVFTNLSRDHLD-FHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQFVKRLPKDITVSAITQP 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  256 ADVRVEDYRQVGAQGHFRLVRQD----KEVLQVTLNAPGRHNAL-NAAAAVAVATEEGIDDSAILRALESFQGTGRRFDf 330
Cdd:TIGR01085 246 ADGRAQDIKITDSGYSFEGQQFTfetpAGEGHLHTPLIGRFNVYnLLAALATLLHLGGIDLEDIVAALEKFRGVPGRME- 324

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 490996147  331 lgeyplaEVNGKSGSAMLIdDYGHHPTEVDATIKAARA 368
Cdd:TIGR01085 325 -------LVDGGQKFLVIV-DYAHTPDALEKALRTLRK 354
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 337-420 5.75e-10

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 55.81  E-value: 5.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147  337 AEVNGKSGSAMLIDDYGHHPTEVDATIKAARaGWPDKNLVMLFQPHRfTRTRDLYDDFANVLTQV-DALLMLDVYSAGEA 415
Cdd:pfam02875   5 LEVVGENNGVLVIDDYAHNPDAMEAALRALR-NLFPGRLILVFGGMG-DRDAEFHALLGRLAAALaDVVILTGDYPRAED 82


                  ....*
gi 490996147  416 PIPGA 420
Cdd:pfam02875  83 PGAII 87
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 122-367 8.65e-10

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 60.92  E-value: 8.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 122 IAIAGTHGKTTTTAMVSSIYAEAG--------LDpTFVNGGLVKAA-------GVHArlghsryLIAEADESDASFL--- 183
Cdd:PRK00139  98 IGVTGTNGKTTTAYLLAQILRLLGektaligtLG-NGIGGELIPSGlttpdalDLQR-------LLAELVDAGVTYAame 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 184 ---H---------LQPMVAIVTNIEADHMDtYHGDFENL---KQTFINFLhnlpfYGRAVMCVDDPVIRELLPRVgrqiT 248
Cdd:PRK00139 170 vssHaldqgrvdgLKFDVAVFTNLSRDHLD-YHGTMEDYlaaKARLFSEL-----GLAAVINADDEVGRRLLALP----D 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 249 TYGFS-EDADVRVEDYRQVGAQGHFRLVRQdkevlqVTLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQG-TGR 326
Cdd:PRK00139 240 AYAVSmAGADLRATDVEYTDSGQTFTLVTE------VESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGvPGR 313

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 490996147 327 --RFDfLGEYPLAEVngksgsamlidDYGHHPTEVDATIKAAR 367
Cdd:PRK00139 314 meRVD-AGQGPLVIV-----------DYAHTPDALEKVLEALR 344
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 122-365 5.54e-09

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 58.56  E-value: 5.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 122 IAIAGTHGKTTTTAMVSSIYAEAGLDptfvNGGLVKAAGVHARLGHSRYLIAEADESDASFLHL---------------Q 186
Cdd:PRK11929 606 VAITGSNGKTTTKEMIAAILAAWQGE----DRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELgmnhpgeiaylaaiaA 681

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 187 PMVAIVTNIEADHMDTYHgDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVG-RQITTYGFSEDADVRVEDYR- 264
Cdd:PRK11929 682 PTVALVTNAQREHQEFMH-SVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGaRRVLRFGLQPGADVYAEKIAk 760

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 265 --QVGAQGHFRL-VRQDKEVLQVTLNAPGRHNALNAAAAVAVATEEGIDDSAILRALESFQGTGRRFDflgeyplaeVNG 341
Cdd:PRK11929 761 diSVGEAGGTRCqVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQ---------RRR 831

                        250       260
                 ....*....|....*....|....*
gi 490996147 342 KSGSAMLIDD-YGHHPTEVDATIKA 365
Cdd:PRK11929 832 LSCGTRIIDDtYNANPDSMRAAIDV 856
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 101-200 2.17e-04

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 43.99  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490996147 101 ARIPVIrraemlaelmrfrhgiAIAGTHGKTTTTAMVSSIYAEAGL-------DPTFVNGGLVK---------------- 157
Cdd:PRK14016 478 GRIPIV----------------AVTGTNGKTTTTRLIAHILKLSGKrvgmtttDGVYIDGRLIDkgdctgpksarrvlmn 541

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 490996147 158 ----------AAGVHAR--LGHSRyliaeADesdasflhlqpmVAIVTNIEADHM 200
Cdd:PRK14016 542 pdveaavletARGGILRegLAYDR-----CD------------VGVVTNIGEDHL 579
FolC COG0285
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; ...
 122-146 6.63e-03

Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 440054 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 6.63e-03
                         10        20
                 ....*....|....*....|....*
gi 490996147 122 IAIAGTHGKTTTTAMVSSIYAEAGL 146
Cdd:COG0285   43 IHVAGTNGKGSTAAMLESILRAAGY 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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