|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
4-462 |
0e+00 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 673.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 4 MRLSKDSVAVGLSWLLTGLILLLVCLFSALIVRDYGRENEAARQTIQEKGSVLIRALESGTRVGMGMRMHHSQLQTLLEE 83
Cdd:PRK10364 1 MQRSKDSLAKWLSALLPVVIVGLVGLFSVTVIRDYGRETAAARQTLLEKGSVLIRALESGSRVGMGMRMHHAQQQALLEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 84 MAWQPGVLWFAVTDENGKIIAHSDPRRVGESLYPASTLRELNIGSEERWRRLEQP--EPALEIYRQFRPLNG-GGHHMRM 160
Cdd:PRK10364 81 MAGQPGVRWFAVTDEQGTIVAHSNPGMVGKQLYSPQEMQQLHPGDEEAWRRIDSAdgEPVLEIYRQFQPMFAaGMHGMRH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 161 MMRRESADlrnqAPQVIFIAFDTRELDADHARGLRNMVIMLCAAGVVMAATVLAQFWFRRYQRSRKQLQEATARKEKLVA 240
Cdd:PRK10364 161 MQQYAAAN----TPQAIFIAFDASNLVSAQAREQRNTLIILFALATVLLASLLAFFWYRRYLRSRQLLQDEMKRKEKLVA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 241 LGHLAAGVAHEIRNPLSSIKGLAKYFAERTPADGEAHQLALVMAREADRLNRVVSELLELVRPAHLKYQSVDLNEVITHS 320
Cdd:PRK10364 237 LGHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTHLALQAVDLNDLINHS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 321 LQLVSQDAASRAISLTFTAQPALCRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGDGrVKVSVADSGKGMTAE 400
Cdd:PRK10364 317 LQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAG-VKISVTDSGKGIAAD 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491008810 401 QLQAIFTPYFSTKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPVNGQQKDEQG 462
Cdd:PRK10364 396 QLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRRDPQG 457
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
225-454 |
1.32e-84 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 264.02 E-value: 1.32e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 225 RKQLQEATARKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERTPaDGEAHQLALVMAREADRLNRVVSELLELVRPA 304
Cdd:COG3852 119 RKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLERELP-DDELREYTQLIIEEADRLNNLVDRLLSFSRPR 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 305 HLKYQSVDLNEVITHSLQLVSQDAASRaISLTFTAQPALCRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGDG 384
Cdd:COG3852 198 PPEREPVNLHEVLERVLELLRAEAPKN-IRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQV 276
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491008810 385 R---------VKVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPVN 454
Cdd:COG3852 277 TlgglrprlyVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLE 355
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
121-453 |
9.29e-79 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 248.94 E-value: 9.29e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 121 LRELNIGSEERWRRLEQPEPALEIYRQFRPLNGGGHHMRMMMRRESADLRNQAPQVIFIAFDTRELDADHARGLRNMVIM 200
Cdd:COG4191 6 LLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 201 LCAAGVVMAATVLAQFWF----------------RRYQRSRKQLQEATARKEKLVALGHLAAGVAHEIRNPLSSIKG--- 261
Cdd:COG4191 86 LLLLLEALLLLLLAALDAeenaeleelerditelERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGnae 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 262 LAKYFAERTPADGEAHQLALVMAREADRLNRVVSELLELVRPAHLKYQSVDLNEVITHSLQLVSQDAASRAISLTFTAQP 341
Cdd:COG4191 166 LLRRRLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 342 ALCRIQADPDRLKQVLLNLYLNAVHAI--GREGVITVAVRECGDgRVKVSVADSGKGMTAEQLQAIFTPYFSTKA--DGT 417
Cdd:COG4191 246 DLPPVLGDPGQLEQVLLNLLINAIDAMeeGEGGRITISTRREGD-YVVISVRDNGPGIPPEVLERIFEPFFTTKPvgKGT 324
|
330 340 350
....*....|....*....|....*....|....*.
gi 491008810 418 GLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:COG4191 325 GLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
225-459 |
5.74e-78 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 254.12 E-value: 5.74e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 225 RKQLQEATARKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERTpaDGEAHQLAL-VMAREADRLNRVVSELLELVRP 303
Cdd:PRK11360 374 RKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQQT--SDPPSQEYLsVVLREVDRLNKVIDQLLEFSRP 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 304 AHLKYQSVDLNEVITHSLQLVSQDAASRAISLTFTAQPALCRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGD 383
Cdd:PRK11360 452 RESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSD 531
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491008810 384 GRVKVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPVNGQQKD 459
Cdd:PRK11360 532 GQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGNQ 607
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
161-458 |
2.99e-75 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 241.79 E-value: 2.99e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 161 MMRRESADLRNQAPQVIFIAFDTRELDADHARGLRNMVIMLCAAGVVMAATVLAQFWFRRYQRSRKQLQEAtARKEKLVA 240
Cdd:COG5000 122 LLGIPLEELIGKPLEELLPELDLAELLREALERGWQEEIELTRDGRRTLLVRASPLRDDGYVIVFDDITEL-LRAERLAA 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 241 LGHLAAGVAHEIRNPLSSIKGLA----KYFAERTPADGEAHQLAL-VMAREADRLNRVVSELLELVRPAHLKYQSVDLNE 315
Cdd:COG5000 201 WGELARRIAHEIKNPLTPIQLSAerlrRKLADKLEEDREDLERALdTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNE 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 316 VITHSLQLVSQDAASRAISLTFTAQPALCRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVReCGDGRVKVSVADSGK 395
Cdd:COG5000 281 LLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTR-REDGRVRIEVSDNGP 359
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491008810 396 GMTAEQLQAIFTPYFSTKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPVNGQQK 458
Cdd:COG5000 360 GIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
225-462 |
2.83e-66 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 220.62 E-value: 2.83e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 225 RKQLQEATARKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAertPADGEAHQLAL-VMAREADRLNRVVSELLELVRP 303
Cdd:COG5809 254 RKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLK---DTIDEEQKTYLdIMLSELDRIESIISEFLVLAKP 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 304 AHLKYQSVDLNEVITHSLQLVSQDAASRAISLTFTAQPALCRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGD 383
Cdd:COG5809 331 QAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDD 410
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491008810 384 GRVKVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPVNGQQKDEQG 462
Cdd:COG5809 411 DKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQVSMN 489
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
141-454 |
3.72e-65 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 212.85 E-value: 3.72e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 141 ALEIYRQFRPLNGGGHHMRMMMRRESADLRNQAPQVIFIAFDTRELDADHARGLRNMVIMLCAAGVVMAATVLAQFWFRR 220
Cdd:COG0642 16 LLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 221 YQRSRKQLQEATARKeklvalGHLAAGVAHEIRNPLSSIKGLAKYFAERTPAdgEAHQLALVMAREADRLNRVVSELLEL 300
Cdd:COG0642 96 LLALLLLLEEANEAK------SRFLANVSHELRTPLTAIRGYLELLLEELDE--EQREYLETILRSADRLLRLINDLLDL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 301 VR----PAHLKYQSVDLNEVITHSLQLVSQDAASRAISLTFTAQPALCRIQADPDRLKQVLLNLYLNAVHAIGREGVITV 376
Cdd:COG0642 168 SRleagKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 377 AVREcGDGRVKVSVADSGKGMTAEQLQAIFTPYFSTKAD----GTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:COG0642 248 SVRR-EGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSrrggGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
|
..
gi 491008810 453 VN 454
Cdd:COG0642 327 LA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
222-453 |
1.28e-61 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 200.52 E-value: 1.28e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 222 QRSRKQLQEATARKEKLVAlghlaaGVAHEIRNPLSSIKGLAKYFAER-TPADGEAHQLALVMAREADRLNRVVSELLEL 300
Cdd:COG2205 3 EEALEELEELERLKSEFLA------NVSHELRTPLTSILGAAELLLDEeDLSPEERRELLEIIRESAERLLRLIEDLLDL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 301 VR----PAHLKYQSVDLNEVITHSLQLVSQDAASRAISLTFTAQPALCRIQADPDRLKQVLLNLYLNAVHAIGREGVITV 376
Cdd:COG2205 77 SRlesgKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 377 AVREcGDGRVKVSVADSGKGMTAEQLQAIFTPYF----STKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:COG2205 157 SARR-EGDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
.
gi 491008810 453 V 453
Cdd:COG2205 236 L 236
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
203-454 |
1.44e-61 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 205.17 E-value: 1.44e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 203 AAGVVMAATVLAQFWFRRYQRSRKQLQEATARKEKLVAlghlaaGVAHEIRNPLSSIKGLAKYFAERTPADGEAHQLAL- 281
Cdd:COG5002 133 RLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVA------NVSHELRTPLTSIRGYLELLLDGAADDPEERREYLe 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 282 VMAREADRLNRVVSELLELVR----PAHLKYQSVDLNEVITHSLQLVSQDAASRAISLTFTAQPALCRIQADPDRLKQVL 357
Cdd:COG5002 207 IILEEAERLSRLVNDLLDLSRlesgELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVL 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 358 LNLYLNAVHAIGREGVITVAVRECGDgRVKVSVADSGKGMTAEQLQAIFTPYF------STKADGTGLGLAVVQNIVEQH 431
Cdd:COG5002 287 TNLLDNAIKYTPEGGTITVSLREEDD-QVRISVRDTGIGIPEEDLPRIFERFYrvdksrSRETGGTGLGLAIVKHIVEAH 365
|
250 260
....*....|....*....|...
gi 491008810 432 GGTIDAESAPGKGALFTFYLPVN 454
Cdd:COG5002 366 GGRIWVESEPGKGTTFTITLPLA 388
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
223-453 |
1.11e-59 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 200.86 E-value: 1.11e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 223 RSRKQLQEATARKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERTPADGEAHQLALVMAREADRLNRVVSELLELVR 302
Cdd:COG5806 183 IENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAK 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 303 PAHLKYQSVDLNEVITHSLQLVSQDAASRAISLTFTAQPALcRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECG 382
Cdd:COG5806 263 PQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEPGL-YIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDK 341
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491008810 383 DgRVKVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:COG5806 342 N-KVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
225-453 |
2.08e-59 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 198.86 E-value: 2.08e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 225 RKQLQEATARKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERTPADgEAHQLALVMAREADRLNRVVSELLELVRPA 304
Cdd:COG5807 131 RKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQESREDS-EREEYFNIIISEIDRINTIITELLVLSKPK 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 305 HLKYQSVDLNEVITHSLQLVSQDAASRAISLTFTAQPALCRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGDG 384
Cdd:COG5807 210 KFNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDF 289
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491008810 385 rVKVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:COG5807 290 -VVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPL 357
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
195-453 |
1.27e-53 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 186.11 E-value: 1.27e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 195 RNMVIMLCAAGVVMAATVLAQFWfrrYQRSRKQLQE-ATAR--KEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERTP 271
Cdd:COG5808 195 QALAIRKLIILVLISIIFLLLQY---NLLKRKTLLErVIQEinTQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYP 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 272 aDGEAHQLALVMAREADRLNRVVSELLELVRPAHLKYQSVDLNEVITHSLQLVSQDAASRAISLTFTAQPALCRIQADPD 351
Cdd:COG5808 272 -ELEDQKYFDIIQEEIQRINQIVSEFLVLGKPTAKKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKD 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 352 RLKQVLLNLYLNAVHAIGREGVITVAVrECGDGRVKVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLAVVQNIVEQH 431
Cdd:COG5808 351 RIKQVLLNLIKNAIEAMKEGGKLTISI-ENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMH 429
|
250 260
....*....|....*....|..
gi 491008810 432 GGTIDAESAPGKGALFTFYLPV 453
Cdd:COG5808 430 GGEIDIESEEGKGTTFTIRLPL 451
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
225-453 |
4.70e-53 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 185.71 E-value: 4.70e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 225 RKQLQEATARKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAertPADGEAHQLALVMAREADRLNRVVSELLELVRPA 304
Cdd:COG5805 271 KKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQLLQ---PGIEDKEEYFDIMLSELDRIESIISEFLALAKPQ 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 305 HLKYQSVDLNEVITHSLQLVSQDAASRAISLTFTAQPALCRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVREcGDG 384
Cdd:COG5805 348 AVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEE-EDN 426
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491008810 385 RVKVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:COG5805 427 SVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
29-454 |
3.81e-41 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 153.40 E-value: 3.81e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 29 LFSALIVRDYGRENEAARQTIQEKGSVLIRALESGTRVGMGMRMHHSQLQTLLEEMAWQPGVLWFAVTDENGKIIAHSDP 108
Cdd:COG4251 62 LLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELA 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 109 RRVGESLYPASTLRELNIGSEERWRRLEQPEPALEIYRQFRPLNGGGHHMRMMMRRESADLRNQAPQVIFIAFDTRELDA 188
Cdd:COG4251 142 LLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSL 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 189 DHARGLRNMVIMLCAAGVVMAATVLAQFWFRRYQRSRKQLQEATARKEKLVA--------LGHLAAGVAHEIRNPLSSIK 260
Cdd:COG4251 222 GGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAelersneeLEQFAYVASHDLREPLRKIS 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 261 GLAKYFAERTPA--DGEAHQLALVMAREADRLNRVVSELLELVR--PAHLKYQSVDLNEVITHSLQLVSQDAASRAISLT 336
Cdd:COG4251 302 GFSQLLEEDYGDklDEEGREYLERIRDAAERMQALIDDLLAYSRvgRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIE 381
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 337 FTAQPalcRIQADPDRLKQVLLNLYLNAV--HAIGREGVITVAVREcGDGRVKVSVADSGKGMTAEQLQAIFTPYF---- 410
Cdd:COG4251 382 VGPLP---TVRGDPTLLRQVFQNLISNAIkySRPGEPPRIEIGAER-EGGEWVFSVRDNGIGIDPEYAEKIFEIFQrlhs 457
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 491008810 411 STKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPVN 454
Cdd:COG4251 458 RDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
219-457 |
1.00e-38 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 149.44 E-value: 1.00e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 219 RRYQRSRKQLQEATARKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERTPADGEAHQLALVMAREADRLNRVVSELL 298
Cdd:PRK13837 428 RRLETERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQIL 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 299 ELVRPAHLKYQSVDLNEVITHSLQLVSQDAASRA-ISLTFTAQPAlcRIQADPDRLKQVLLNLYLNAVHAIGREGVITVA 377
Cdd:PRK13837 508 AFGRKGERNTKPFDLSELVTEIAPLLRVSLPPGVeLDFDQDQEPA--VVEGNPAELQQVLMNLCSNAAQAMDGAGRVDIS 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 378 VR-------------ECGDGR-VKVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLAVVQNIVEQHGGTIDAESAPGK 443
Cdd:PRK13837 586 LSraklrapkvlshgVLPPGRyVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGR 665
|
250
....*....|....
gi 491008810 444 GALFTFYLPVNGQQ 457
Cdd:PRK13837 666 GTRFDVYLPPSSKV 679
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
348-453 |
2.45e-35 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 126.99 E-value: 2.45e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 348 ADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGDgRVKVSVADSGKGMTAEQLQAIFTPYFSTKAD-----GTGLGLA 422
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGD-HVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 491008810 423 VVQNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-453 |
4.04e-34 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 123.69 E-value: 4.04e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 350 PDRLKQVLLNLYLNAVHAIGREGVITVAVRECGDgRVKVSVADSGKGMTAEQLQAIFTPYFSTK--ADGTGLGLAVVQNI 427
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVD-QVLIEVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYRI 79
|
90 100
....*....|....*....|....*.
gi 491008810 428 VEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:cd16943 80 IQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
348-453 |
5.25e-31 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 115.16 E-value: 5.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 348 ADPDRLKQVLLNLYLNAVHAIGREGVITVAVREcgDGRVKVSVADSGKGMTAEQLQAIFTPYFS---TKADGTGLGLAVV 424
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSE--GGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIV 78
|
90 100
....*....|....*....|....*....
gi 491008810 425 QNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
222-453 |
1.41e-30 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 120.96 E-value: 1.41e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 222 QR--SRKQLQEAtarkeKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERTPaDGEAHQLALVMAREADRLNRVVSELLE 299
Cdd:PRK11073 114 QRrlSQEQLQHA-----QQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALP-DPALTEYTKVIIEQADRLRNLVDRLLG 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 300 LVRPAHLKYQSvdLNEVITHSLQLVSQDAASRaISLTFTAQPALCRIQADPDRLKQVLLNLYLNAVHAIGRE-GVITVAV 378
Cdd:PRK11073 188 PQRPGTHVTES--IHKVAERVVQLVSLELPDN-VRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQALGPEgGTITLRT 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 379 RECGDGRV---------KVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGAlFTF 449
Cdd:PRK11073 265 RTAFQLTLhgeryrlaaRIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGHTE-FSV 343
|
....
gi 491008810 450 YLPV 453
Cdd:PRK11073 344 YLPI 347
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
353-451 |
1.52e-30 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 113.85 E-value: 1.52e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHAIGREGVITVAVRECGDGrVKVSVADSGKGMTAEQLQAIFTPYFSTKAD----GTGLGLAVVQNIV 428
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDG-VVLEVEDNGPGIPEEDLERIFERFYRGDKSreggGTGLGLAIVRRIV 79
|
90 100
....*....|....*....|...
gi 491008810 429 EQHGGTIDAESAPGKGALFTFYL 451
Cdd:cd00075 80 EAHGGRITVESEPGGGTTFTVTL 102
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
223-456 |
3.72e-27 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 112.25 E-value: 3.72e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 223 RSRKQLQEATARKEKLVALGHLAAGVAHEIRNPLSSIKGLAKyfaertpaDGEAHQLALVMAREADRLNRVVSELLELVr 302
Cdd:COG3290 171 RDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQ--------LGEYDEALEYIDEISEELQELIDSLLSRI- 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 303 pahlkyQSVDLNEVithsLQLVSQDAASRAISLTFTAQPALCRIQADPDRLKQVLLNLYLNAVHAI----GREGVITVAV 378
Cdd:COG3290 242 ------GNPVLAAL----LLGKAARARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVeklpEEERRVELSI 311
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491008810 379 RECGDgRVKVSVADSGKGMTAEQLQAIFTPYFSTKA-DGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPVNGQ 456
Cdd:COG3290 312 RDDGD-ELVIEVEDSGPGIPEELLEKIFERGFSTKLgEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
220-453 |
2.04e-26 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 110.04 E-value: 2.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 220 RYQRSRKQLQEATARKEKLVALghlaagVAHEIRNPLS-------SIK-GLAKYFAERTPADGEahQLALVMAREADRLN 291
Cdd:PRK09303 136 VLRQENETLLEQLKFKDRVLAM------LAHDLRTPLTaaslaleTLElGQIDEDTELKPALIE--QLQDQARRQLEEIE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 292 RVVSELLELVRP--AHLKYQSVDLNevithsLQLVSQDAAS------RAISLTFTAQ-PA-LCRIQADPDRLKQVLLNLY 361
Cdd:PRK09303 208 RLITDLLEVGRTrwEALRFNPQKLD------LGSLCQEVILelekrwLAKSLEIQTDiPSdLPSVYADQERIRQVLLNLL 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 362 LNAVHAIGREGVITVAVRECGDGRVKVSVADSGKGMTAEQLQAIFTPYF----STKADGTGLGLAVVQNIVEQHGGTIDA 437
Cdd:PRK09303 282 DNAIKYTPEGGTITLSMLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGLSVCRRIVRVHYGQIWV 361
|
250
....*....|....*.
gi 491008810 438 ESAPGKGALFTFYLPV 453
Cdd:PRK09303 362 DSEPGQGSCFHFTLPV 377
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
353-453 |
2.31e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 102.57 E-value: 2.31e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHaIGREGVITVAVR----ECGDGRVKVSVADSGKGMTAEQLQAIFTPY------FSTKADGTGLGLA 422
Cdd:cd16922 1 LRQILLNLLGNAIK-FTEEGEVTLRVSleeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|.
gi 491008810 423 VVQNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
225-457 |
3.45e-26 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 111.30 E-value: 3.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 225 RKQLQEATARKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYF---AERTPADGEAHQLALVMAREA-DRLNRVVSELLEL 300
Cdd:PRK13557 147 RRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIqaaLSHPDADRGRMARSVENIRAAaERAATLTQQLLAF 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 301 VRPAHLKYQSVDLNEVITHSLQLVSQdAASRAISLTFTAQPAL--CRIqaDPDRLKQVLLNLYLNAVHAIGREGVITVAV 378
Cdd:PRK13557 227 ARKQRLEGRVLNLNGLVSGMGELAER-TLGDAVTIETDLAPDLwnCRI--DPTQAEVALLNVLINARDAMPEGGRVTIRT 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 379 R--ECGD-----------GR-VKVSVADSGKGMTAEQLQAIFTPYFSTKADG--TGLGLAVVQNIVEQHGGTIDAESAPG 442
Cdd:PRK13557 304 RnvEIEDedlamyhglppGRyVSIAVTDTGSGMPPEILARVMDPFFTTKEEGkgTGLGLSMVYGFAKQSGGAVRIYSEVG 383
|
250
....*....|....*
gi 491008810 443 KGALFTFYLPVNGQQ 457
Cdd:PRK13557 384 EGTTVRLYFPASDQA 398
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-452 |
3.75e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 101.70 E-value: 3.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHAI------GREgvITVAVRECGDGRVKVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLAVVQN 426
Cdd:cd16920 1 IQQVLINLVRNGIEAMseggceRRE--LTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRS 78
|
90 100
....*....|....*....|....*.
gi 491008810 427 IVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:cd16920 79 IIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
219-446 |
5.94e-24 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 105.15 E-value: 5.94e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 219 RRYQRSRKQLQEATARKEKLVALGHLAAGVAHEIRNPLSSIKglAKYFAERTPADGEAHQLALV----MAREADRLNRVV 294
Cdd:COG4192 411 KRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMS--MYLFSAKKALEQENYAQLPTsldkIEGLIERMDKII 488
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 295 SELLELVRPAHLKYQSVDLNEVITHSLQLVSQDAASRAISLTftaQPALCRIQADPDRLKQVLLNLYLNAVHAIGREGVI 374
Cdd:COG4192 489 KSLRQFSRKSDTPLQPVDLRQVIEQAWELVESRAKPQQITLH---IPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQI 565
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491008810 375 TVAVREcGDGRVKVSVADSGKGMtaEQLQAIFTPYFSTKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGAL 446
Cdd:COG4192 566 SVDLLS-NAENLRVAISDNGNGW--PLVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAM 634
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
249-453 |
8.18e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 103.77 E-value: 8.18e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 249 AHEIRNPLSSIKGLAKYFAERTPADGEAHQLALVmAREADRLNRVVSELLELV----RPAHLKYQSVDLNEVITHSLQLV 324
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQEDPPPEDRARFTGNI-LTQSARLQQLIDRLLELArleqRQELEVLEPVALAALLEELVEAR 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 325 SQDAASRAISLTFTAQPAlcRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVrECGDGRVKVSVADSGKGMTAEQLQA 404
Cdd:PRK11100 343 EAQAAAKGITLRLRPDDA--RVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSA-EVDGEQVALSVEDQGPGIPDYALPR 419
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 491008810 405 IFTPYFS-----TKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:PRK11100 420 IFERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
223-454 |
9.11e-24 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 104.72 E-value: 9.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 223 RSRKQLQEATARKEKlvalgHLAAgVAHEIRNPLSSIKGlAKYFAERTPADGEAHQLALVMAREADRLNRVVSELLELVR 302
Cdd:PRK15347 386 EAKQRAEQANKRKSE-----HLTT-ISHEIRTPLNGVLG-ALELLQNTPLTAEQMDLADTARQCTLSLLAIINNLLDFSR 458
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 303 ----PAHLKYQSVDLNEVITHSLQLVSQDAASRAISL-TFTAQPALCRIQADPDRLKQVLLNLYLNAVHaIGREGVITVA 377
Cdd:PRK15347 459 iesgQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLrTFVGAHVPLYLHLDSLRLRQILVNLLGNAVK-FTETGGIRLR 537
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491008810 378 VRECGDgRVKVSVADSGKGMTAEQLQAIFTPYF--STKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPVN 454
Cdd:PRK15347 538 VKRHEQ-QLCFTVEDTGCGIDIQQQQQIFTPFYqaDTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLN 615
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
241-443 |
5.53e-23 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 100.93 E-value: 5.53e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 241 LGHLAAGVAHEIRNPLSSIKGLAKyFAERTPADGEAHQLALVM-AREADRLNRVVSELLELVRP----AHLKYQSVDLNE 315
Cdd:TIGR01386 241 LSQFSADLAHELRTPLTNLLGQTQ-VALSQPRTGEEYREVLESnLEELERLSRMVSDMLFLARAdngqLALERVRLDLAA 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 316 VITHSLQLVSQDAASRAISLTFTAQpalCRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGDgRVKVSVADSGK 395
Cdd:TIGR01386 320 ELAKVAEYFEPLAEERGVRIRVEGE---GLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSD-EVRVSVSNPGP 395
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 491008810 396 GMTAEQLQAIFTPYF------STKADGTGLGLAVVQNIVEQHGGTIDAESAPGK 443
Cdd:TIGR01386 396 GIPPEHLSRLFDRFYrvdparSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK 449
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-451 |
6.02e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 90.21 E-value: 6.02e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHAIGR--EGVITVAVRECGdGRVKVSVADSGKGMTAEQLQAIFTPYFSTK--ADGTGLGLAVVQNIV 428
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKveNPRIRIAARRLG-GRLVLVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISYGIV 79
|
90 100
....*....|....*....|...
gi 491008810 429 EQHGGTIDAESAPGKGALFTFYL 451
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
353-452 |
1.54e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 89.36 E-value: 1.54e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHAIGREGVITV-------------AVRECGDGR-VKVSVADSGKGMTAEQLQAIFTPYFSTK--ADG 416
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIetsnqrvdadyalNYRDLIPGNyVCLEVSDTGSGMPAEVLRRAFEPFFTTKevGKG 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 491008810 417 TGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
224-454 |
2.36e-21 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 97.32 E-value: 2.36e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 224 SRKQLQEA--TARKEKlvalGHLAAGVAHEIRNPLSSIKGLAKYFAErTPADGEAHQLALVMAREADRLNRVVSELLEL- 300
Cdd:PRK11091 268 ERKRYQDAleKASRDK----TTFISTISHELRTPLNGIVGLSRILLD-TELTAEQRKYLKTIHVSAITLGNIFNDIIDMd 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 301 ---VRPAHLKYQSVDLNEVITHSLQLVSQDAASRAISLTFTAQPALCR-IQADPDRLKQVLLNLYLNAVHaIGREGVITV 376
Cdd:PRK11091 343 kmeRRKLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLPLPHkVITDGTRLRQILWNLISNAVK-FTQQGGVTV 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 377 AV-RECGDgRVKVSVADSGKGMTAEQLQAIFTPYFSTK-------ADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFT 448
Cdd:PRK11091 422 RVrYEEGD-MLTFEVEDSGIGIPEDELDKIFAMYYQVKdshggkpATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFT 500
|
....*.
gi 491008810 449 FYLPVN 454
Cdd:PRK11091 501 LTIHAP 506
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-452 |
2.47e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 88.75 E-value: 2.47e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 349 DPDRLKQVLLNLYLNAVHAI-GRE---GVITVAVRECGDGRVKVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLAVV 424
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIeGRPsdvGEVRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIV 80
|
90 100
....*....|....*....|....*...
gi 491008810 425 QNIVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:cd16944 81 KKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-452 |
5.43e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 87.84 E-value: 5.43e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHAIGRE-GVITVAVRECGDGRV---------KVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLA 422
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSgGEIILRTRTQRQVTLghprhrlalRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80
|
90 100 110
....*....|....*....|....*....|
gi 491008810 423 VVQNIVEQHGGTIDAESAPGKgALFTFYLP 452
Cdd:cd16918 81 IAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
244-454 |
1.33e-20 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 95.10 E-value: 1.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 244 LAAGVAHEIRNPLSSIKGLAKYFAERTPADGEAHqlalvmAREADR-----LN--RVVSELLELVRPA----HLKYQSVD 312
Cdd:PRK10490 667 LLAALSHDLRTPLTVLFGQAEILTLDLASEGSPH------ARQASEirqqvLNttRLVNNLLDMARIQsggfNLRKEWLT 740
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 313 LNEVITHSLQLVSQDAASRAISLTFTAQPALcrIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGDgRVKVSVAD 392
Cdd:PRK10490 741 LEEVVGSALQMLEPGLSGHPINLSLPEPLTL--IHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGE-RLQLDVWD 817
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491008810 393 SGKGMTAEQLQAIFTPYfsTKAD------GTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPVN 454
Cdd:PRK10490 818 NGPGIPPGQEQLIFDKF--ARGNkesaipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLE 883
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
349-452 |
7.70e-20 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 84.47 E-value: 7.70e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 349 DPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGDGRVKVSVADSGKGMTAEQLQAIFTPY------FSTKADGTGLGLA 422
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFrqgdgsSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 491008810 423 VVQNIVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
246-452 |
1.65e-19 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 90.45 E-value: 1.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 246 AGVAHEIRNPLSSIKGLAKYFAERT---PADGEAHQlalVMAREADRLNRVVSELLELVR----PAHlkyqsvDLNEV-- 316
Cdd:PRK11006 209 ANVSHELRTPLTVLQGYLEMMQDQPlegALREKALH---TMREQTQRMEGLVKQLLTLSKieaaPTI------DLNEKvd 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 317 ITHSLQLVSQDAAS---RAISLTFTAQPALcRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGDGrVKVSVADS 393
Cdd:PRK11006 280 VPMMLRVLEREAQTlsqGKHTITFEVDNSL-KVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQG-AEFSVEDN 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491008810 394 GKGMTAEQLQAIfTPYF-------STKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:PRK11006 358 GPGIAPEHIPRL-TERFyrvdkarSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
239-453 |
2.54e-19 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 91.33 E-value: 2.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 239 VALGHLAAGVAHEIRNPLSSIKGlakyFAERTPADG-------EAHQLALVMAREadrLNRVVSELLELVRPA----HLK 307
Cdd:PRK09959 710 VAKSQFLATMSHEIRTPISSIMG----FLELLSGSGlskeqrvEAISLAYATGQS---LLGLIGEILDVDKIEsgnyQLQ 782
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 308 YQSVDLNEVITHSLQLVSQDAASRAISLTFTAQ-PALCRIQADPDRLKQVLLNLYLNAVHAIGREGV-ITVAVRECGDGR 385
Cdd:PRK09959 783 PQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTfPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVkITTSLGHIDDNH 862
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491008810 386 --VKVSVADSGKGMTAEQLQAIFTPYFSTKA----DGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:PRK09959 863 avIKMTIMDSGSGLSQEEQQQLFKRYSQTSAgrqqTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
246-454 |
4.61e-19 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 89.31 E-value: 4.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 246 AGVAHEIRNPLSSIKGLAKYFAE--RTPadgEAHQLALVMArEADRLNRVVSEL--LELVRPAHLKYQ--SVDLNEVITH 319
Cdd:PRK10549 245 ADISHELRTPLAVLRGELEAIQDgvRKF---TPESVASLQA-EVGTLTKLVDDLhqLSLSDEGALAYRktPVDLVPLLEV 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 320 SLQLVSQDAASRAISLTfTAQPALCRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECgDGRVKVSVADSGKGMTA 399
Cdd:PRK10549 321 AGGAFRERFASRGLTLQ-LSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQR-DKTLRLTFADSAPGVSD 398
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491008810 400 EQLQAIFTPYFSTKAD------GTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPVN 454
Cdd:PRK10549 399 EQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLE 459
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
248-452 |
2.67e-18 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 86.91 E-value: 2.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 248 VAHEIRNPLSSIKgLAKYFAERTpaDGEAHQLAlvmaR---EADRLNRVVSELLELVR---PAHLKYQSVDLNEVITHSL 321
Cdd:PRK09470 250 ISHELRTPLTRLQ-LATALLRRR--QGESKELE----RietEAQRLDSMINDLLVLSRnqqKNHLERETFKANSLWSEVL 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 322 QLVSQDAASRAISLTFTAQPALCRIQADPDRLKQVLLNLYLNAVHAIGREgvITVAVRECGDGrVKVSVADSGKGMTAEQ 401
Cdd:PRK09470 323 EDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTK--IEVAFSVDKDG-LTITVDDDGPGVPEEE 399
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 491008810 402 LQAIFTPYF--STKAD----GTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:PRK09470 400 REQIFRPFYrvDEARDresgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-452 |
7.63e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 79.04 E-value: 7.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 349 DPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGDGrVKVSVADSGKGMTAEQLQAIFTPYFSTK------ADGTGLGLA 422
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQE-VRLDVEDSAPGVSDDQLARLFERFYRVEssrnraSGGSGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 491008810 423 VVQNIVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:cd16946 80 ICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
246-453 |
3.22e-17 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 84.57 E-value: 3.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 246 AGVAHEIRNPLSSIKGLAKYFAERtPADGEAHQLALVMAREADRLNRVVSELLELvRPAHLKYQSVDLNE-------VIT 318
Cdd:PRK11466 449 AAMSHEIRTPLYGILGTAQLLADN-PALNAQRDDLRAITDSGESLLTILNDILDY-SAIEAGGKNVSVSDepfeprpLLE 526
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 319 HSLQLVSQDAASRAISLTFTAQPAL-CRIQADPDRLKQVLLNLYLNAVHAIGReGVITVAVReCGDGRVKVSVADSGKGM 397
Cdd:PRK11466 527 STLQLMSGRVKGRPIRLATDIADDLpTALMGDPRRIRQVITNLLSNALRFTDE-GSIVLRSR-TDGEQWLVEVEDSGCGI 604
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 491008810 398 TAEQLQAIFTPY--FSTKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:PRK11466 605 DPAKLAEIFQPFvqVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-452 |
4.27e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 76.56 E-value: 4.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 359 NLYLNAVHAIGREGV----ITVAVRECGDgRVKVSVADSGKGMTAEQLQAIFTPYFSTKADGT-GLGLAVVQNIVEQHGG 433
Cdd:cd16915 7 NLIDNALDALAATGApnkqVEVFLRDEGD-DLVIEVRDTGPGIAPELRDKVFERGVSTKGQGErGIGLALVRQSVERLGG 85
|
90
....*....|....*....
gi 491008810 434 TIDAESAPGKGALFTFYLP 452
Cdd:cd16915 86 SITVESEPGGGTTFSIRIP 104
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-452 |
1.73e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 75.06 E-value: 1.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHAI--GREGVITVAVRECGDGRVkVSVADSGKGMTAEQLQAIFTPYFSTKAD----GTGLGLAVVQN 426
Cdd:cd16921 1 LGQVLTNLLGNAIKFRrpRRPPRIEVGAEDVGEEWT-FYVRDNGIGIDPEYAEKVFGIFQRLHSReeyeGTGVGLAIVRK 79
|
90 100
....*....|....*....|....*.
gi 491008810 427 IVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:cd16921 80 IIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
356-459 |
2.69e-16 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 81.11 E-value: 2.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 356 VLLNLYLNAVHAIGR--EGVITVAVREcGDGRVKVSVADSGKGMTAEQLQAIFTPYFSTKADGTGLGLAVVQNIVEQHGG 433
Cdd:PRK11086 437 ILGNLIENALEAVGGeeGGEISVSLHY-RNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGG 515
|
90 100
....*....|....*....|....*.
gi 491008810 434 TIDAESAPGKGALFTFYLPVNGQQKD 459
Cdd:PRK11086 516 SIAVESEPGVGTQFFVQIPWDGERSN 541
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
244-453 |
3.74e-16 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 80.34 E-value: 3.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 244 LAAGVAHEIRNPLSSIKgLAkyfAERTPADGEahQLALVMAREADRLNRVVSELLELVRP-AHLKYQSVDLNEVITHSLQ 322
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIR-LA---TEMMSEEDG--YLAESINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNALLGEVIA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 323 LVSQDAasRAISLTFTAQPalCRIQADPDRLKQVLLNLYLNAVhaigREGVITVAVRECGDG-RVKVSVADSGKGMTAEQ 401
Cdd:PRK09467 306 AESGYE--REIETALQPGP--IEVPMNPIAIKRALANLVVNAA----RYGNGWIKVSSGTEGkRAWFQVEDDGPGIPPEQ 377
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 491008810 402 LQAIFTPYfsTKAD------GTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:PRK09467 378 LKHLFQPF--TRGDsargssGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
247-453 |
2.36e-15 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 77.72 E-value: 2.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 247 GVAHEIRNPLSSIKglakYFAERTPADGEAHQLALvmAREADRLNRVVSELL---ELVRP-AHLKYQSVDLNEVIT---H 319
Cdd:PRK10604 218 GIAHELRTPLVRLR----YRLEMSDNLSAAESQAL--NRDIGQLEALIEELLtyaRLDRPqNELHLSEPDLPAWLSthlA 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 320 SLQLVSQDaasRAISLTfTAQPALcRIQADPDRLKQVLLNLYLNAV-HAIGRegvitVAVRECGDG-RVKVSVADSGKGM 397
Cdd:PRK10604 292 DIQAVTPE---KTVRLD-TPHQGD-YGALDMRLMERVLDNLLNNALrYAHSR-----VRVSLLLDGnQACLIVEDDGPGI 361
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491008810 398 TAEQLQAIFTPYF------STKADGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:PRK10604 362 PPEERERVFEPFVrldpsrDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
245-452 |
6.22e-15 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 76.73 E-value: 6.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 245 AAGVAHEIRNPLSSIKGLAKYFAERTPADGEAHQLALVMAREADRLNRVVSELLELVRP----AHLKYQSVDLNEVITHS 320
Cdd:PRK09835 266 SADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQAdnnqLIPEKKMLDLADEVGKV 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 321 LQLVSQDAASRAISLTFTAQPalCRIQADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGDgRVKVSVADSGKGMTAE 400
Cdd:PRK09835 346 FDFFEAWAEERGVELRFVGDP--CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDH-QVQLVVENPGTPIAPE 422
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 491008810 401 QLQAIFTPYFST------KADGTGLGLAVVQNIVEQHGGTIDAESAPgKGALFTFYLP 452
Cdd:PRK09835 423 HLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-452 |
1.46e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 69.28 E-value: 1.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHaIGREGVITVAVREcgDGRVKVSVADSGKGMTAEQLQAIFTPYF------STKADGTGLGLAVVQN 426
Cdd:cd16949 1 LARALENVLRNALR-YSPSKILLDISQD--GDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAER 77
|
90 100
....*....|....*....|....*.
gi 491008810 427 IVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:cd16949 78 AIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-444 |
2.45e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 66.28 E-value: 2.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 346 IQADPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGDGRVKVSvaDSGKGMTAEQLQAIFTPYF---STKADGTGLGLA 422
Cdd:cd16940 7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVE--DNGPGIDEEELEALFERFYrsdGQNYGGSGLGLS 84
|
90 100
....*....|....*....|..
gi 491008810 423 VVQNIVEQHGGTIDAESAPGKG 444
Cdd:cd16940 85 IVKRIVELHGGQIFLGNAQGGG 106
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
351-452 |
5.33e-13 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 67.22 E-value: 5.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 351 DRLKQVLLNLYLNAV-HAI-----------GREGVITVAVRECGdGRVKVSVADSGKGM---------------TAEQLQ 403
Cdd:cd16916 37 EKLADPLTHLLRNAVdHGIeapeerlaagkPPEGTITLRAEHQG-NQVVIEVSDDGRGIdrekirekaiergliTADEAA 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491008810 404 A---------IFTPYFSTKAD-----GTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:cd16916 116 TlsddevlnlIFAPGFSTAEQvtdvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
245-433 |
7.37e-13 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 69.61 E-value: 7.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 245 AAGVAHEIRNPLSSIKGLAKYFAERTPADGeahqlALVMAReADRLNRVVSELLELVRP----AHLKYQSVDL-NEVITH 319
Cdd:PRK10755 141 TADVAHELRTPLAGIRLHLELLEKQHHIDV-----APLIAR-LDQMMHTVEQLLQLARAgqsfSSGHYQTVKLlEDVILP 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 320 SLQLVSQDAASRAISLTFTAQPALCRIQADPDRLKQVLLNLYLNAvHAIGREG-VITVAVRECGDGrVKVSVADSGKGMT 398
Cdd:PRK10755 215 SQDELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENA-HRYSPEGsTITIKLSQEDGG-AVLAVEDEGPGID 292
|
170 180 190
....*....|....*....|....*....|....*..
gi 491008810 399 AEQLQAIFTPY--FSTKADGTGLGLAVVQNIVEQHGG 433
Cdd:PRK10755 293 ESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHG 329
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
238-302 |
1.40e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 62.62 E-value: 1.40e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491008810 238 LVALGHLAAGVAHEIRNPLSSIKGLAKYFAERTPADGEAHQLALVMAREADRLNRVVSELLELVR 302
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
349-454 |
2.11e-12 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 69.49 E-value: 2.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 349 DPDRLKQVLLNLYLNAVHAIGREGV-ITVAVRECGDGRV--KVSVADSGKGMTAEQLQAIFTPYfsTKAD--------GT 417
Cdd:PRK11107 405 DPLRLQQIITNLVGNAIKFTESGNIdILVELRALSNTKVqlEVQIRDTGIGISERQQSQLFQAF--RQADasisrrhgGT 482
|
90 100 110
....*....|....*....|....*....|....*..
gi 491008810 418 GLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPVN 454
Cdd:PRK11107 483 GLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPLD 519
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
246-457 |
2.52e-12 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 69.23 E-value: 2.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 246 AGVAHEIRNPLSSIKG-LAKYFAERTPAdgEAHQLALVMAREADRLNRVVSELLEL--VRPAHLKYQSVDLN--EVITH- 319
Cdd:PRK10841 452 ATVSHELRTPLYGIIGnLDLLQTKELPK--GVDRLVTAMNNSSSLLLKIISDILDFskIESEQLKIEPREFSprEVINHi 529
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 320 ---SLQLVsqdaASRAISLTFTAQPAL-CRIQADPDRLKQVLLNLYLNAVHaIGREGVITVAVReCGDGRVKVSVADSGK 395
Cdd:PRK10841 530 tanYLPLV----VKKRLGLYCFIEPDVpVALNGDPMRLQQVISNLLSNAIK-FTDTGCIVLHVR-VDGDYLSFRVRDTGV 603
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491008810 396 GMTAEQLQAIFTPYFSTKA------DGTGLGLAVVQNIVEQHGGTIDAESAPGKGALFTFYLPVNGQQ 457
Cdd:PRK10841 604 GIPAKEVVRLFDPFFQVGTgvqrnfQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPLYGAQ 671
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
240-302 |
3.09e-12 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 61.43 E-value: 3.09e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491008810 240 ALGHLAAGVAHEIRNPLSSIKGLAKyFAERTPADGEAHQLALVMAREADRLNRVVSELLELVR 302
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLE-LLLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-452 |
4.09e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 62.47 E-value: 4.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVhaigREGVITVAVRECGDG-RVKVSVADSGKGMTAEQLQAIFTPYF----STKADGTGLGLAVVQNI 427
Cdd:cd16950 1 LKRVLSNLVDNAL----RYGGGWVEVSSDGEGnRTRIQVLDNGPGIAPEEVDELFQPFYrgdnARGTSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 491008810 428 VEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
240-302 |
5.09e-12 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 61.07 E-value: 5.09e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491008810 240 ALGHLAAGVAHEIRNPLSSIKGLAKyFAERTPADGEAHQLALVMAREADRLNRVVSELLELVR 302
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLE-LLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
1.68e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 60.52 E-value: 1.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHAIGREGVITVAVRecgDGRVKVSVADSGKGMTAEQLQAIFTPYF------STKADGTGLGLAVVQN 426
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVS---GGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHR 77
|
90 100
....*....|....*....|....*..
gi 491008810 427 IVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:cd16939 78 VALWHGGHVECDDSELGGACFRLTWPR 104
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
198-455 |
1.78e-11 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 64.25 E-value: 1.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 198 VIMLCAAGVVMAATVLAQFWFRRYQRSRKQLQEATARKEKLVA--LGHLAA----GVAHEirnpLSSIKGLAKYFAERTP 271
Cdd:COG4585 9 ALALLVGALLGLLLALVLLRARRAERAAELERELAARAEEAREeeRRRIARelhdGVGQS----LSAIKLQLEAARRLLD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 272 ADGEAHQLALVMARE-ADRLNRVVSELLELVRPAHLkyQSVDLNEVIThslQLVSQDAASRAISLTFTAQPALCRIQADp 350
Cdd:COG4585 85 ADPEAAREELEEIRElAREALAELRRLVRGLRPPAL--DDLGLAAALE---ELAERLLRAAGIRVELDVDGDPDRLPPE- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 351 drlkqVLLNLYL-------NAV-HAIGREGVITVavrECGDGRVKVSVADSGKGMTAEQlqaiftpyfstkADGTGLGLA 422
Cdd:COG4585 159 -----VELALYRivqealtNALkHAGATRVTVTL---EVDDGELTLTVRDDGVGFDPEA------------APGGGLGLR 218
|
250 260 270
....*....|....*....|....*....|...
gi 491008810 423 VVQNIVEQHGGTIDAESAPGKGALFTFYLPVNG 455
Cdd:COG4585 219 GMRERAEALGGTLTIGSAPGGGTRVRATLPLAA 251
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
345-456 |
4.24e-11 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 64.65 E-value: 4.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 345 RIQADPDRLKQVLLNLYL-----NAV-HAI---GREGVITVAVRECGDgRVKVSVADSGKGMTAEQLQAIFTPyFSTKAD 415
Cdd:COG2972 324 EIEIDEELLDLLIPKLILqplveNAIeHGIepkEGGGTIRISIRKEGD-RLVITVEDNGVGMPEEKLEKLLEE-LSSKGE 401
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 491008810 416 GTGLGLAVVQNIVEQH---GGTIDAESAPGKGALFTFYLPVNGQ 456
Cdd:COG2972 402 GRGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTIRIPLEEE 445
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
249-444 |
8.25e-11 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 63.90 E-value: 8.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 249 AHEIRNPLSSIKGLAKyFAERTPADGEAHQLALVMAREA-DRLNRVVSELLELVRPAHLK----YQSVDLNEVITHSL-- 321
Cdd:PRK10337 245 AHELRSPLAALKVQTE-VAQLSDDDPQARKKALLQLHAGiDRATRLVDQLLTLSRLDSLDnlqdVAEIPLEDLLQSAVmd 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 322 QLVSQDAASRAISLTFTAQPALCRIQadPDRLKQVLLNLYLNAVHAIGREGVITVAVRECGdgrvkVSVADSGKGMTAEQ 401
Cdd:PRK10337 324 IYHTAQQAGIDVRLTLNAHPVIRTGQ--PLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN-----FTVRDNGPGVTPEA 396
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 491008810 402 LQAIFTPYF---STKADGTGLGLAVVQNIVEQHGGTIDAESAPGKG 444
Cdd:PRK10337 397 LARIGERFYrppGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-452 |
9.33e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 58.84 E-value: 9.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHAIGREGVITVAVrECGDGRVKVSVADSGKGMTAEQLQAIFTPYFSTKAD-----GTGLGLAVVQNI 427
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYS-ETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGrnfqeSTGMGLYLVKKL 84
|
90 100
....*....|....*....|....*
gi 491008810 428 VEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:cd16948 85 CDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
370-453 |
1.05e-10 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 63.66 E-value: 1.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 370 REGVITVAVRECGdGRVKVSVADSGKGM---------------TAEQLQA---------IFTPYFSTKAD-----GTGLG 420
Cdd:COG0643 307 ETGTITLSAYHEG-GRVVIEVSDDGRGLdlekirakaiekgliTAEEAAAlsdeellelIFAPGFSTAEEvtdlsGRGVG 385
|
90 100 110
....*....|....*....|....*....|...
gi 491008810 421 LAVVQNIVEQHGGTIDAESAPGKGALFTFYLPV 453
Cdd:COG0643 386 MDVVKTNIEALGGTIEIESEPGKGTTFTLRLPL 418
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-452 |
1.07e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 58.74 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHAIGRE-GVITVAVRECGDgRVKVSVADSGKGMTAEQLQAIFTPYFSTKADG------TGLGLAVVQ 425
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDtGRITVSAMPTGK-MVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 491008810 426 NIVEQHGGTIDAE--SAPG--KGALFTFYLP 452
Cdd:cd16953 80 QIIEAHGGISVAEnhNQPGqvIGARFTVQLP 110
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
321-447 |
2.11e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 58.41 E-value: 2.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 321 LQLVSQDaasRAISLTFTAQPALcRIQADPDRLKQVLLNLYLNAV-HAIGRegvITVAVREcGDGRVKVSVADSGKGMTA 399
Cdd:cd16954 10 LNKVYQR---KGVSISLDISPEL-RFPGERNDLMELLGNLLDNACkWCLEF---VEVTARQ-TDGGLHLIVDDDGPGVPE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 491008810 400 EQLQAIFTPyfSTKAD----GTGLGLAVVQNIVEQHGGTIDAESAPGKGALF 447
Cdd:cd16954 82 SQRSKIFQR--GQRLDeqrpGQGLGLAIAKEIVEQYGGELSLSDSPLGGARF 131
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-452 |
9.00e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 56.06 E-value: 9.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHAIGREGVITVAVRECGDGrVKVSVADSGKGMTAEQLQAIFTPYF------STKADGTGLGLAVVQN 426
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESG-ARLSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKH 79
|
90 100
....*....|....*....|....*.
gi 491008810 427 IVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:cd16952 80 VMSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-451 |
2.87e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 54.83 E-value: 2.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 347 QADPDRLKQVLLNLYLNAVHAIGREGVITVAVREcGDGRVKVSVADSGKGMTAEQLQAIFTPYFSTKAD------GTGLG 420
Cdd:cd16947 15 NANTEALQRILKNLISNAIKYGSDGKFLGMTLRE-DEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSrnsakqGNGLG 93
|
90 100 110
....*....|....*....|....*....|.
gi 491008810 421 LAVVQNIVEQHGGTIDAESAPGKGALFTFYL 451
Cdd:cd16947 94 LTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-451 |
4.18e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 54.00 E-value: 4.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 349 DPDRLKQVLLNLYLNAVHAIGREGVITVAVrECGDGRVKVSVADSGKGMTAEQLQAIFTPYFS-----TKADGTGLGLAV 423
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQL-EADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAF 79
|
90 100
....*....|....*....|....*...
gi 491008810 424 VQNIVEQHGGTIDAESAPGkGALFTFYL 451
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPD-GVLAFLTL 106
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-452 |
7.03e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 53.16 E-value: 7.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 353 LKQVLLNLYLNAVHAIGREGVITVAVRECGDgRVKVSVADSGKGMTAEQLQAIFTPYF----STKADGTGLGLAVVQNIV 428
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDD-VVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|....
gi 491008810 429 EQHGGTIDAESApGKGALFTFYLP 452
Cdd:cd16923 80 ELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
4.42e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 50.92 E-value: 4.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 349 DPDRLKQVLLNLYLNAVHAIGREGVITVAVrECGDGRVKVSVADSGKGMTAEQLQAIFTPYFSTKADGT-----GLGLAV 423
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISI-YDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGLYI 79
|
90 100
....*....|....*....|....*.
gi 491008810 424 VQNIVEQHGGTIDAESAPGKGALFTF 449
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
309-453 |
1.49e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 50.29 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 309 QSVDLNEVITHSLQLVSQDAASRAISLTFTAQPalcrIQADPDRLKQV--LLN-LYLNAV-HAI--GREGVITVAVReCG 382
Cdd:COG3920 357 EGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD----VELPADAAVPLglILNeLVTNALkHAFlsGEGGRIRVSWR-RE 431
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491008810 383 DGRVKVSVADSGKGMTAEqlqaiftpyfSTKADGTGLGLAVVQNIVEQHGGTIDAESAPgkGALFTFYLPV 453
Cdd:COG3920 432 DGRLRLTVSDNGVGLPED----------VDPPARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPL 490
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-452 |
4.73e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 45.14 E-value: 4.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 354 KQVLLNLYLNAV-HAI---GREGVITVAVRECGDGRVKVSVADSGKGMTAEQLQAIFTPYFstkaDGTGLGLAVVQNIVE 429
Cdd:cd16955 3 KLMIQPLVENAIvHGIqekKGKGVVKISVKKQLKNRLHIAVEDNGIGISPKVIERVEQDEM----PGNKIGLLNVHQRLK 78
|
90 100
....*....|....*....|....
gi 491008810 430 Q-HGGTIDAESAPGKGALFTFYLP 452
Cdd:cd16955 79 LgYGEGLHIRSRPDPGTLIAFYIP 102
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-452 |
8.27e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 44.36 E-value: 8.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 363 NA-VHAIG---REGVITVAVRECgDGRVKVSVADSGKGMtaeqlQAIFTPYFSTKAD-GTGLGLAVV-QNIVEQHGG--T 434
Cdd:cd16924 12 NAiQHGLSpltDKGVVTISALKE-DNHVMIEVEDNGRGI-----DPKVLNILGKKPKeGNGIGLYNVhQRLILLFGEdyG 85
|
90
....*....|....*...
gi 491008810 435 IDAESAPGKGALFTFYLP 452
Cdd:cd16924 86 IHIASEPDKGTRITFTIP 103
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
349-452 |
1.71e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 47.13 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 349 DPDRLKQVLLNLYLNAVHAIGR----EGVITVAVRECGDgRVKVSVADSGKGMTAEQLQAIFTPYFSTKADGT---GLGL 421
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEASLRsdegNKIVELFLSDEGD-DVVIEVADQGCGVPESLRDKIFEQGVSTRADEPgehGIGL 507
|
90 100 110
....*....|....*....|....*....|.
gi 491008810 422 AVVQNIVEQHGGTIDAESAPGKGALFTFYLP 452
Cdd:PRK15053 508 YLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| sCache_3_2 |
pfam17203 |
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ... |
40-120 |
1.15e-04 |
|
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 435783 [Multi-domain] Cd Length: 140 Bit Score: 42.01 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 40 RENEAARQTIQEKGSVLIRAL--ESGTRVGMGMRMHHSQLQTLLEEMAWQPGVLWFAVTDENGKIIAHSDPRRVGESLYP 117
Cdd:pfam17203 1 QLRADLTRQLERRALALARSVaaSPVVRVALTDPEPYPGLQALVESVRRITGADYVVIADRRGRVLAHPDPERVGRRLSG 80
|
...
gi 491008810 118 AST 120
Cdd:pfam17203 81 PAT 83
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
382-445 |
1.27e-03 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 41.16 E-value: 1.27e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491008810 382 GDGRVKVSVADSGKGMTAEQLQAIFTPyfSTKAD----GTGLGLAVVQNIVEQHGGTIDAESAPGKGA 445
Cdd:PRK10815 405 TDEHLHIVVEDDGPGIPESKRELIFDR--GQRADtlrpGQGLGLSVAREITEQYEGKISAGDSPLGGA 470
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
369-454 |
1.45e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 41.20 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 369 GREGVITVAVRECGDGRVKVSVADSGKGMTAEqlqaiftpyFSTKADGTgLGLAVVQNIVEQHGGTIDAESApgKGALFT 448
Cdd:PRK13560 731 GAAGNIKVEIREQGDGMVNLCVADDGIGLPAG---------FDFRAAET-LGLQLVCALVKQLDGEIALDSR--GGARFN 798
|
....*.
gi 491008810 449 FYLPVN 454
Cdd:PRK13560 799 IRFPMS 804
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-452 |
4.57e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 36.38 E-value: 4.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 363 NAV-HAIGREGVITVAvreCGDGRVKVSVADSGKGMTAEqlqaiftpyfsTKADGTGLGLAVVQNIVEQHGGTIDAESAP 441
Cdd:cd16917 11 NALkHAGASRVRVTLS---YTADELTLTVVDDGVGFDGP-----------APPGGGGFGLLGMRERAELLGGTLTIGSRP 76
|
90
....*....|.
gi 491008810 442 GKGALFTFYLP 452
Cdd:cd16917 77 GGGTRVTARLP 87
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
328-429 |
5.85e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 36.88 E-value: 5.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491008810 328 AASRAISLTFTAqpALCRIQADPDRLKQVLLNLY---LNAV-HA--IGREGVITVAVrECGDGRVKVSVADSGKGMTAEQ 401
Cdd:pfam13581 6 EQLRAARRVLEA--VLRRAGLPEELLDEVELAVGeacTNAVeHAyrEGPEGPVEVRL-TSDGGGLVVTVADSGPPFDPLT 82
|
90 100
....*....|....*....|....*...
gi 491008810 402 LQAIFTPYFSTKADGTGLGLAVVQNIVE 429
Cdd:pfam13581 83 LPPPDLEEPDEDRKEGGRGLALIRGLMD 110
|
|
| |
