|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01259 |
PRK01259 |
ribose-phosphate diphosphokinase; |
4-314 |
0e+00 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 234929 [Multi-domain] Cd Length: 309 Bit Score: 606.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 4 MKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAG 83
Cdd:PRK01259 1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 84 RITAVIPYFGYARQDRRVRSaRVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQKNLEN 163
Cdd:PRK01259 81 RITAVIPYFGYARQDRKARS-RVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNLEN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 164 PIVVSPDIGGVVRARAIAKLLNdTDMAIIDKRRPRANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERGAKR 243
Cdd:PRK01259 160 LVVVSPDVGGVVRARALAKRLD-ADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491048952 244 VFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPLSPEIKALSNVRTLTLSGMLAEAIRRISNEESISAMFE 314
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
|
|
| PrsA |
COG0462 |
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ... |
1-314 |
0e+00 |
|
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis
Pssm-ID: 440230 [Multi-domain] Cd Length: 311 Bit Score: 542.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 1 MPDMKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRA 80
Cdd:COG0462 1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 81 SAGRITAVIPYFGYARQDRRVRsARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQKN 160
Cdd:COG0462 81 SARRITAVIPYYGYARQDRKFR-PREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSKD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 161 LENPIVVSPDIGGVVRARAIAKLLnDTDMAIIDKRRPRANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERG 240
Cdd:COG0462 160 LEDLVVVSPDVGGVKRARAFAKRL-GAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491048952 241 AKRVFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPLSPEiKALSNVRTLTLSGMLAEAIRRISNEESISAMFE 314
Cdd:COG0462 239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
|
|
| ribP_PPkin |
TIGR01251 |
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ... |
4-314 |
2.67e-157 |
|
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273523 [Multi-domain] Cd Length: 308 Bit Score: 441.72 E-value: 2.67e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 4 MKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFII-QSTCAPTNDNLMELVVMVDALRRASA 82
Cdd:TIGR01251 1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 83 GRITAVIPYFGYARQDRRVRSaRVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQKNLE 162
Cdd:TIGR01251 81 KSITAVIPYYGYARQDKKFKS-REPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 163 NPIVVSPDIGGVVRARAIAKLLNdTDMAIIDKRRP-RANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERGA 241
Cdd:TIGR01251 160 NPVVVSPDAGGVERAKKVADALG-CPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491048952 242 KRVFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPLSpeiKALSNVRTLTLSGMLAEAIRRISNEESISAMFE 314
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
|
|
| Pribosyltran_N |
pfam13793 |
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ... |
4-121 |
8.58e-71 |
|
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.
Pssm-ID: 433483 [Multi-domain] Cd Length: 117 Bit Score: 214.98 E-value: 8.58e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 4 MKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAG 83
Cdd:pfam13793 1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80
|
90 100 110
....*....|....*....|....*....|....*...
gi 491048952 84 RITAVIPYFGYARQDRRVRSaRVPITAKVVADFLSSVG 121
Cdd:pfam13793 81 RITAVIPYFGYARQDRKDKP-REPITAKLVADLLEAAG 117
|
|
| PRTases_typeI |
cd06223 |
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ... |
149-274 |
1.00e-27 |
|
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.
Pssm-ID: 206754 [Multi-domain] Cd Length: 130 Bit Score: 104.40 E-value: 1.00e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 149 SPILLEDMLQKNLENPIVVSPDIGGVVRARAIAKLLNdTDMAIIDKRRPRANVSQVM------HIIGDVSGRDCILVDDM 222
Cdd:cd06223 2 GRLLAEEIREDLLEPDVVVGILRGGLPLAAALARALG-LPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVDDV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 491048952 223 IDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAvdNIKNSVIDEVIVCDT 274
Cdd:cd06223 81 IATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01259 |
PRK01259 |
ribose-phosphate diphosphokinase; |
4-314 |
0e+00 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 234929 [Multi-domain] Cd Length: 309 Bit Score: 606.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 4 MKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAG 83
Cdd:PRK01259 1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 84 RITAVIPYFGYARQDRRVRSaRVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQKNLEN 163
Cdd:PRK01259 81 RITAVIPYFGYARQDRKARS-RVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNLEN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 164 PIVVSPDIGGVVRARAIAKLLNdTDMAIIDKRRPRANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERGAKR 243
Cdd:PRK01259 160 LVVVSPDVGGVVRARALAKRLD-ADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491048952 244 VFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPLSPEIKALSNVRTLTLSGMLAEAIRRISNEESISAMFE 314
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
|
|
| PrsA |
COG0462 |
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ... |
1-314 |
0e+00 |
|
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis
Pssm-ID: 440230 [Multi-domain] Cd Length: 311 Bit Score: 542.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 1 MPDMKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRA 80
Cdd:COG0462 1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 81 SAGRITAVIPYFGYARQDRRVRsARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQKN 160
Cdd:COG0462 81 SARRITAVIPYYGYARQDRKFR-PREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSKD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 161 LENPIVVSPDIGGVVRARAIAKLLnDTDMAIIDKRRPRANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERG 240
Cdd:COG0462 160 LEDLVVVSPDVGGVKRARAFAKRL-GAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491048952 241 AKRVFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPLSPEiKALSNVRTLTLSGMLAEAIRRISNEESISAMFE 314
Cdd:COG0462 239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
|
|
| PRK04923 |
PRK04923 |
ribose-phosphate diphosphokinase; |
2-313 |
1.80e-159 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 179893 [Multi-domain] Cd Length: 319 Bit Score: 447.84 E-value: 1.80e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 2 PDMKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRAS 81
Cdd:PRK04923 5 RNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRAS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 82 AGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDML-QKN 160
Cdd:PRK04923 85 AASVTAVIPYFGYSRQDRRMRSSRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADIWrAYG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 161 LENPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERG 240
Cdd:PRK04923 165 TDNLIVVSPDVGGVVRARAVAKRLDDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAAALKQRG 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491048952 241 AKRVFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPLSPEIKALSNVRTLTLSGMLAEAIRRISNEESISAMF 313
Cdd:PRK04923 245 ALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
|
|
| ribP_PPkin |
TIGR01251 |
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ... |
4-314 |
2.67e-157 |
|
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273523 [Multi-domain] Cd Length: 308 Bit Score: 441.72 E-value: 2.67e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 4 MKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFII-QSTCAPTNDNLMELVVMVDALRRASA 82
Cdd:TIGR01251 1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 83 GRITAVIPYFGYARQDRRVRSaRVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQKNLE 162
Cdd:TIGR01251 81 KSITAVIPYYGYARQDKKFKS-REPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 163 NPIVVSPDIGGVVRARAIAKLLNdTDMAIIDKRRP-RANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERGA 241
Cdd:TIGR01251 160 NPVVVSPDAGGVERAKKVADALG-CPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491048952 242 KRVFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPLSpeiKALSNVRTLTLSGMLAEAIRRISNEESISAMFE 314
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
|
|
| PLN02369 |
PLN02369 |
ribose-phosphate pyrophosphokinase |
13-313 |
2.34e-136 |
|
ribose-phosphate pyrophosphokinase
Pssm-ID: 215209 [Multi-domain] Cd Length: 302 Bit Score: 388.28 E-value: 2.34e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 13 PELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAGRITAVIPYF 92
Cdd:PLN02369 1 PALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 93 GYARQDRRvRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQKNL--ENPIVVSPD 170
Cdd:PLN02369 81 GYARADRK-TQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTIssPDLVVVSPD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 171 IGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERGAKRVFAYATH 250
Cdd:PLN02369 160 VGGVARARAFAKKLSDAPLAIVDKRRQGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATH 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491048952 251 PIFSGNAVDNIKNSVIDEVIVCDTIPLSPEiKALSNVRTLTLSGMLAEAIRRISNEESISAMF 313
Cdd:PLN02369 240 AVFSPPAIERLSSGLFQEVIVTNTIPVSEK-NYFPQLTVLSVANLLGETIWRVHDDCSVSSIF 301
|
|
| PRK02812 |
PRK02812 |
ribose-phosphate pyrophosphokinase; Provisional |
4-313 |
5.00e-135 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 235072 [Multi-domain] Cd Length: 330 Bit Score: 386.02 E-value: 5.00e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 4 MKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAG 83
Cdd:PRK02812 22 LRLFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRASAR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 84 RITAVIPYFGYARQDRRVrSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQKNLEN 163
Cdd:PRK02812 102 QITAVIPYYGYARADRKT-AGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLASKNLED 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 164 PIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERGAKR 243
Cdd:PRK02812 181 IVVVSPDVGGVARARAFAKKLNDAPLAIIDKRRQAHNVAEVLNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGAKQ 260
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 244 VFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPLsPEIKALSNVRTLTLSGMLAEAIRRISNEESISAMF 313
Cdd:PRK02812 261 VYACATHAVFSPPAIERLSSGLFEEVIVTNTIPV-PEERRFPQLKVLSVANMLGEAIWRIHEESSVSSMF 329
|
|
| PRK02269 |
PRK02269 |
ribose-phosphate diphosphokinase; |
3-314 |
1.28e-131 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 167353 [Multi-domain] Cd Length: 320 Bit Score: 377.21 E-value: 1.28e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 3 DMKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASA 82
Cdd:PRK02269 5 DLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 83 GRITAVIPYFGYARQDRRVRSaRVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQKNL- 161
Cdd:PRK02269 85 ESINVVMPYYGYARQDRKARS-REPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRRGLv 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 162 -ENPIVVSPDIGGVVRARAIAKLLNdTDMAIIDKRRP--RANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKE 238
Cdd:PRK02269 164 gDDVVVVSPDHGGVTRARKLAQFLK-TPIAIIDKRRSvdKMNTSEVMNIIGNVKGKKCILIDDMIDTAGTICHAADALAE 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491048952 239 RGAKRVFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPLsPEIKALSNVRTLTLSGMLAEAIRRISNEESISAMFE 314
Cdd:PRK02269 243 AGATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIYL-PEERLIDKIEQISIADLLGEAIIRIHEKRPLSPLFE 317
|
|
| PTZ00145 |
PTZ00145 |
phosphoribosylpyrophosphate synthetase; Provisional |
1-313 |
7.26e-125 |
|
phosphoribosylpyrophosphate synthetase; Provisional
Pssm-ID: 240290 [Multi-domain] Cd Length: 439 Bit Score: 364.19 E-value: 7.26e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 1 MPDMKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRA 80
Cdd:PTZ00145 117 MENAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRA 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 81 SAGRITAVIPYFGYARQDRRVrSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFD--VPVDNVFGSPILLEDMLQ 158
Cdd:PTZ00145 197 SAKKITAVIPYYGYARQDRKL-SSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNLEAQLIGLDYFTK 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 159 KNLENPIVVSPDIGGVVRARA-----IAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAA 233
Cdd:PTZ00145 276 KDLYKPVIVSPDAGGVYRARKfqdglNHRGISDCGIAMLIKQRTKPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEAA 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 234 EALKERGAKRVFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPLSPEIKALSNVRTLTLSGMLAEAIRRISNEESISAMF 313
Cdd:PTZ00145 356 KQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDLF 435
|
|
| PRK03092 |
PRK03092 |
ribose-phosphate diphosphokinase; |
15-314 |
3.76e-114 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 179535 [Multi-domain] Cd Length: 304 Bit Score: 331.91 E-value: 3.76e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 15 LAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAGRITAVIPYFGY 94
Cdd:PRK03092 1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 95 ARQDRRVRsARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQK-NLENPIVVSPDIGG 173
Cdd:PRK03092 81 ARQDKKHR-GREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKyDLDNVTVVSPDAGR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 174 VVRARAIAKLLNDTDMAIIDKRRP--RANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERGAKRVFAYATHP 251
Cdd:PRK03092 160 VRVAEQWADRLGGAPLAFIHKTRDptVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHG 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491048952 252 IFSGNAVDNIKNSVIDEVIVCDTIPLSPEiKALSNVRTLTLSGMLAEAIRRISNEESISAMFE 314
Cdd:PRK03092 240 VLSGPAAERLKNCGAREVVVTDTLPIPEE-KRFDKLTVLSIAPLLARAIREVFEDGSVTSLFD 301
|
|
| PRK02458 |
PRK02458 |
ribose-phosphate pyrophosphokinase; Provisional |
2-315 |
2.13e-102 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 235039 [Multi-domain] Cd Length: 323 Bit Score: 302.81 E-value: 2.13e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 2 PDMKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRAS 81
Cdd:PRK02458 8 KQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 82 AGRITAVIPYFGYARQDrRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQKNL 161
Cdd:PRK02458 88 ANTVNVVLPYFGYARQD-RIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCKKGL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 162 --ENPIVVSPDIGGVVRARAIAKLLnDTDMAIIDKRRPRANVSQvMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKER 239
Cdd:PRK02458 167 sgSDVVVVSPKNSGIKRARSLAEYL-DAPIAIIDYAQDDSEREE-GYIIGDVAGKKAILIDDILNTGKTFAEAAKIVERE 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491048952 240 GAKRVFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIplSPEIKALSNVRTLTLSGMLAEAIRRISNEESISAMFEH 315
Cdd:PRK02458 245 GATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSV--ATKERVPKNVTYLSASELIADAIIRIHERKPLSPLFAY 318
|
|
| PRK00553 |
PRK00553 |
ribose-phosphate pyrophosphokinase; Provisional |
6-314 |
8.27e-98 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 179062 [Multi-domain] Cd Length: 332 Bit Score: 291.82 E-value: 8.27e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 6 LFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAGRI 85
Cdd:PRK00553 12 IFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKRGSAKSI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 86 TAVIPYFGYARQDRRVRsARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQKN-LENP 164
Cdd:PRK00553 92 TAILPYYGYARQDRKTA-GREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFLSRVLELLgKKDL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 165 IVVSPDIGGVVRARAIAKLLNdTDMAIIDKRRPRANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERGAKRV 244
Cdd:PRK00553 171 VVVSPDYGGVKRARLIAESLE-LPLAIIDKRRPKHNVAESINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKV 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491048952 245 FAYATHPIFSGNAVDNI----KNSVIDEVIVCDTIPLSpEIKALSNVRTLTLSGMLAEAIRRISNEESISAMFE 314
Cdd:PRK00553 250 CVMATHGLFNKNAIQLFdeafKKKLIDKLFVSNSIPQT-KFEKKPQFKVVDLAHLYEEVLLCYANGGSISAIYT 322
|
|
| PRK00934 |
PRK00934 |
ribose-phosphate pyrophosphokinase; Provisional |
5-302 |
1.81e-73 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 234868 [Multi-domain] Cd Length: 285 Bit Score: 227.87 E-value: 1.81e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 5 KLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTcAPTNDNLMELVVMVDALRRASAGR 84
Cdd:PRK00934 1 MIIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTT-YPQDENLVELLLLIDALRDEGAKS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 85 ITAVIPYFGYARQDRRVRSARvPITAKVVADFLSSVGvDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQKnLENP 164
Cdd:PRK00934 80 ITLVIPYLGYARQDKRFKPGE-PISARAIAKIISAYY-DRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGDK-LDDP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 165 IVVSPDIGGVVRARAIAKLLNdTDMAIIDKRR--PRANVSQVMHIigDVSGRDCILVDDMIDTGGTLCKAAEALKERGAK 242
Cdd:PRK00934 157 LVLAPDKGALELAKEAAEILG-CEYDYLEKTRisPTEVEIAPKNL--DVKGKDVLIVDDIISTGGTMATAIKILKEQGAK 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 243 RVFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPlspeikalSNVRTLTLSGMLAEAIRR 302
Cdd:PRK00934 234 KVYVACVHPVLVGDAILKLYNAGVDEIIVTDTLE--------SEVSKISVAPLIADLLKK 285
|
|
| Pribosyltran_N |
pfam13793 |
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ... |
4-121 |
8.58e-71 |
|
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.
Pssm-ID: 433483 [Multi-domain] Cd Length: 117 Bit Score: 214.98 E-value: 8.58e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 4 MKLFAGNATPELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAG 83
Cdd:pfam13793 1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80
|
90 100 110
....*....|....*....|....*....|....*...
gi 491048952 84 RITAVIPYFGYARQDRRVRSaRVPITAKVVADFLSSVG 121
Cdd:pfam13793 81 RITAVIPYFGYARQDRKDKP-REPITAKLVADLLEAAG 117
|
|
| PRK06827 |
PRK06827 |
phosphoribosylpyrophosphate synthetase; Provisional |
34-310 |
2.40e-47 |
|
phosphoribosylpyrophosphate synthetase; Provisional
Pssm-ID: 180714 [Multi-domain] Cd Length: 382 Bit Score: 163.20 E-value: 2.40e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 34 RFSDGEVSVQINENVRGGDIFIIQSTC---------------APtNDNLMELVVMVDALRrASAGRITAVIPYFGYARQD 98
Cdd:PRK06827 61 RFSNGEAKGEILESVRGKDIYILQDVGnysvtynmfgeknhmSP-DDHFQDLKRTIDAIR-GKARRITVIMPFLYESRQH 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 99 RRvrSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQ------GFfdvpvDNVFGS----PILLEDM--LQKNLENPIV 166
Cdd:PRK06827 139 KR--KGRESLDCALALQELEELGVDNIITFDAHDPRIEnaiplmGF-----ENLYPSyqiiKALLKNEkdLEIDKDHLMV 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 167 VSPDIGGVVRARAIAKLLNdTDMAIIDKRRPRANVSQ-----VMH-IIG-DVSGRDCILVDDMIDTGGTLCKAAEALKER 239
Cdd:PRK06827 212 ISPDTGAMDRAKYYASVLG-VDLGLFYKRRDYSRVVNgrnpiVAHeFLGrDVEGKDVLIVDDMIASGGSMIDAAKELKSR 290
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491048952 240 GAKRVFAYATHPIFSgNAVDNI----KNSVIDEVIVCDTIPLSPEIKALSNVRTLTLSGMLAEAIRRISNEESIS 310
Cdd:PRK06827 291 GAKKIIVAATFGFFT-NGLEKFdkayEEGYFDRIIGTNLVYHPEELLSKPWYIEVDMSKLIARIIDALNHDVSLS 364
|
|
| PRK07199 |
PRK07199 |
ribose-phosphate diphosphokinase; |
7-302 |
1.52e-45 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 235960 [Multi-domain] Cd Length: 301 Bit Score: 156.25 E-value: 1.52e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 7 FAGNAtpELAQRVANRLYTNLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPtNDNLMELVVMVDALRRASAGRIT 86
Cdd:PRK07199 8 LPGNE--AAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCSLDRP-DEKLLPLLFAAEAARELGARRVG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 87 AVIPYFGYARQDRRVRSARVpITAKVVADFLSSVgVDRVLTVDLHAEQI---QGFFDVPVDNVFGSPiLLEDMLQKNLEN 163
Cdd:PRK07199 85 LVAPYLAYMRQDIAFHPGEA-ISQRHFARLLSGS-FDRLVTVDPHLHRYpslSEVYPIPAVVLSAAP-AIAAWIRAHVPR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 164 PIVVSPDIGGVVRARAIAKLLnDTDMAIIDK-RRPRANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERGAK 242
Cdd:PRK07199 162 PLLIGPDEESEQWVAAVAERA-GAPHAVLRKtRHGDRDVEISLPDAAPWAGRTPVLVDDIVSTGRTLIEAARQLRAAGAA 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 243 RVFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPLSpeikalSNvrTLTLSGMLAEAIRR 302
Cdd:PRK07199 241 SPDCVVVHALFAGDAYSALAAAGIARVVSTDTVPHP------SN--AISLAPLLAEALRR 292
|
|
| Pribosyl_synth |
pfam14572 |
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ... |
205-313 |
5.58e-30 |
|
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.
Pssm-ID: 434046 Cd Length: 184 Bit Score: 112.22 E-value: 5.58e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 205 MHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAVDNIKNSVIDEVIVCDTIPLSPEIKAL 284
Cdd:pfam14572 75 MTVVGDVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQC 154
|
90 100
....*....|....*....|....*....
gi 491048952 285 SNVRTLTLSGMLAEAIRRISNEESISAMF 313
Cdd:pfam14572 155 HKIKTIDISQLIAEAIRRIHNGESMSYLF 183
|
|
| PRTases_typeI |
cd06223 |
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ... |
149-274 |
1.00e-27 |
|
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.
Pssm-ID: 206754 [Multi-domain] Cd Length: 130 Bit Score: 104.40 E-value: 1.00e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 149 SPILLEDMLQKNLENPIVVSPDIGGVVRARAIAKLLNdTDMAIIDKRRPRANVSQVM------HIIGDVSGRDCILVDDM 222
Cdd:cd06223 2 GRLLAEEIREDLLEPDVVVGILRGGLPLAAALARALG-LPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVDDV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 491048952 223 IDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAvdNIKNSVIDEVIVCDT 274
Cdd:cd06223 81 IATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
|
|
| PLN02297 |
PLN02297 |
ribose-phosphate pyrophosphokinase |
6-300 |
7.65e-20 |
|
ribose-phosphate pyrophosphokinase
Pssm-ID: 177934 [Multi-domain] Cd Length: 326 Bit Score: 88.21 E-value: 7.65e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 6 LFAGNATPELAQRVANR-LYTNLGDAAVGRFSDGEVSVQIN--ENVRGGDIFIIQSTCAPtnDNLMELVVMVDALRRASA 82
Cdd:PLN02297 19 LFYCEETEELARKIAAEsDAIELGSINWRKFPDGFPNLFINnaHGIRGQHVAFLASFSSP--AVIFEQLSVIYALPKLFV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 83 GRITAVIPYFGYARQDRRVRSARVPiTAKVVADFLSSV-----GVDRVLTVDLHAEQIQGFFDvpvDNVF-----GSPIL 152
Cdd:PLN02297 97 ASFTLVLPFFPTGTSERVEREGDVA-TAFTLARILSNIpisrgGPTSLVIFDIHALQERFYFG---DNVLpcfesGIPLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 153 LEDMLQ-KNLENPIVVSPDIGGVVRaraIAKLLNDTDMAIIDKRRpRANVSQVMHIIGDVSGRDCILVDDMIDTGGTLCK 231
Cdd:PLN02297 173 KKRLQQlPDSDNIVIAFPDDGAWKR---FHKQFEHFPMVVCTKVR-EGDKRIVRIKEGNPAGRHVVIVDDLVQSGGTLIE 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491048952 232 AAEALKERGAKRVFAYATHPIFSG------NAVDNIKNSVIDEVIVCDTIPLSpeIKALSNVR---TLTLSGMLAEAI 300
Cdd:PLN02297 249 CQKVLAAHGAAKVSAYVTHGVFPNeswerfTHDNGGPEAGFAYFWITDSCPQT--VKAVRGKApfeVLSLAGSIADAL 324
|
|
| Pribosyltran |
pfam00156 |
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ... |
158-244 |
1.24e-15 |
|
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.
Pssm-ID: 425489 [Multi-domain] Cd Length: 150 Bit Score: 72.78 E-value: 1.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 158 QKNLENPIVVSPDIGGVVRARAIAKLLnDTDMAIIDKRRPRANVSQVM---HIIGDVSGRDCILVDDMIDTGGTLCKAAE 234
Cdd:pfam00156 25 DYGGKPDVVVGILRGGLPFAGILARRL-DVPLAFVRKVSYNPDTSEVMktsSALPDLKGKTVLIVDDILDTGGTLLKVLE 103
|
90
....*....|
gi 491048952 235 ALKERGAKRV 244
Cdd:pfam00156 104 LLKNVGPKEV 113
|
|
| HptA |
COG0634 |
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ... |
210-244 |
6.11e-08 |
|
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage
Pssm-ID: 440399 Cd Length: 176 Bit Score: 51.57 E-value: 6.11e-08
10 20 30
....*....|....*....|....*....|....*
gi 491048952 210 DVSGRDCILVDDMIDTGGTLCKAAEALKERGAKRV 244
Cdd:COG0634 88 DIEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASV 122
|
|
| PRK02277 |
PRK02277 |
orotate phosphoribosyltransferase-like protein; Provisional |
155-244 |
8.11e-08 |
|
orotate phosphoribosyltransferase-like protein; Provisional
Pssm-ID: 235023 [Multi-domain] Cd Length: 200 Bit Score: 51.79 E-value: 8.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 155 DMLQKNLENP-IVVSPDIGGVVRARAIAKLLnDTDMAII--------DKRRPRANVSQVMhiiGDVSGRDCILVDDMIDT 225
Cdd:PRK02277 77 DMLEKEDEEVdVVVGIAKSGVPLATLVADEL-GKDLAIYhpkkwdhgEGEKKTGSFSRNF---ASVEGKRCVIVDDVITS 152
|
90
....*....|....*....
gi 491048952 226 GGTLCKAAEALKERGAKRV 244
Cdd:PRK02277 153 GTTMKETIEYLKEHGGKPV 171
|
|
| upp |
PRK00129 |
uracil phosphoribosyltransferase; Reviewed |
210-246 |
1.52e-07 |
|
uracil phosphoribosyltransferase; Reviewed
Pssm-ID: 234653 Cd Length: 209 Bit Score: 50.86 E-value: 1.52e-07
10 20 30
....*....|....*....|....*....|....*..
gi 491048952 210 DVSGRDCILVDDMIDTGGTLCKAAEALKERGAKRVFA 246
Cdd:PRK00129 121 DIDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKV 157
|
|
| Hpt1 |
COG2236 |
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ... |
169-244 |
1.05e-06 |
|
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage
Pssm-ID: 441837 [Multi-domain] Cd Length: 153 Bit Score: 47.53 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 169 PDI------GGVVRARAIAKLLNDTDMAII--------DKRRPRANVSQvmHIIGDVSGRDCILVDDMIDTGGTLCKAAE 234
Cdd:COG2236 32 PDVivaiarGGLVPARILADALGVPDLASIrvssytgtAKRLEEPVVKG--PLDEDLAGKRVLIVDDVADTGRTLEAVRD 109
|
90
....*....|
gi 491048952 235 ALKERGAKRV 244
Cdd:COG2236 110 LLKEAGPAEV 119
|
|
| PLN02238 |
PLN02238 |
hypoxanthine phosphoribosyltransferase |
210-244 |
1.77e-04 |
|
hypoxanthine phosphoribosyltransferase
Pssm-ID: 215132 Cd Length: 189 Bit Score: 41.56 E-value: 1.77e-04
10 20 30
....*....|....*....|....*....|....*
gi 491048952 210 DVSGRDCILVDDMIDTGGTLCKAAEALKERGAKRV 244
Cdd:PLN02238 94 DVKGKHVLLVEDIVDTGNTLSALVAHLEAKGAASV 128
|
|
| PyrE |
COG0461 |
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ... |
152-242 |
1.45e-03 |
|
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis
Pssm-ID: 440229 Cd Length: 201 Bit Score: 38.98 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048952 152 LLEDMLQKNLENP-IVVSPDIGGVVRARAIAKLLNdTDMAIIdkRRPRANVSQVMHIIGDV-SGRDCILVDDMIDTGGTL 229
Cdd:COG0461 52 ALAELIKELGPEFdAVAGPATGGIPLAAAVARALG-LPAIFV--RKEAKDHGTGGQIEGGLlPGERVLVVEDVITTGGSV 128
|
90
....*....|...
gi 491048952 230 CKAAEALKERGAK 242
Cdd:COG0461 129 LEAVEALREAGAE 141
|
|
| PRK09162 |
PRK09162 |
hypoxanthine-guanine phosphoribosyltransferase; Provisional |
194-246 |
2.70e-03 |
|
hypoxanthine-guanine phosphoribosyltransferase; Provisional
Pssm-ID: 181675 Cd Length: 181 Bit Score: 37.92 E-value: 2.70e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 491048952 194 KRRPRANVSqvmhiigdvsGRDCILVDDMIDTGGTLCKAAEALKERGAKRVFA 246
Cdd:PRK09162 88 KVKPRESLK----------GRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYS 130
|
|
| PTZ00149 |
PTZ00149 |
hypoxanthine phosphoribosyltransferase; Provisional |
205-244 |
5.58e-03 |
|
hypoxanthine phosphoribosyltransferase; Provisional
Pssm-ID: 240293 Cd Length: 241 Bit Score: 37.82 E-value: 5.58e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 491048952 205 MHIIGD----VSGRDCILVDDMIDTGGTLCKAAEALKERGAKRV 244
Cdd:PTZ00149 138 LEIVSDdlscLKDKHVLIVEDIIDTGNTLVKFCEYLKKFEPKTI 181
|
|
| PLN02293 |
PLN02293 |
adenine phosphoribosyltransferase |
204-244 |
7.24e-03 |
|
adenine phosphoribosyltransferase
Pssm-ID: 177930 Cd Length: 187 Bit Score: 36.96 E-value: 7.24e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 491048952 204 VMHIIGDVSGRDCILVDDMIDTGGTLCKAAEALKERGAKRV 244
Cdd:PLN02293 116 EMHVGAVEPGERALVIDDLIATGGTLCAAINLLERAGAEVV 156
|
|
| UPRTase |
pfam14681 |
Uracil phosphoribosyltransferase; This family includes the enzyme uracil ... |
209-242 |
7.91e-03 |
|
Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.
Pssm-ID: 434124 Cd Length: 204 Bit Score: 37.09 E-value: 7.91e-03
10 20 30
....*....|....*....|....*....|....
gi 491048952 209 GDVSGRDCILVDDMIDTGGTLCKAAEALKERGAK 242
Cdd:pfam14681 114 KDISDRTVILLDPMLATGGSAIAAIQVLREHGVP 147
|
|
| |
