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MULTISPECIES: pyruvate dehydrogenase (acetyl-transferring), homodimeric type [Providencia]
Protein Classification
pyruvate dehydrogenase (acetyl-transferring), homodimeric type ( domain architecture ID 11484099 )
E1 component of the acetyl-transferring homodimeric-type pyruvate dehydrogenase multienzyme complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2
List of domain hits
Name
Accession
Description
Interval
E-value
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
1-888
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1938.78
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 1 M S DMLK ND V DPIET RD WL Q A IE SVIREEG VD RA QFII EQ V L SE AR KG GV NIA A G A S gh SD YINTI A VE D EP A YPG NMD LE 80
Cdd:PRK09405 4 G S ESQL ND I DPIET QE WL E A LD SVIREEG PE RA HYLL EQ L L ER AR EK GV SLP A S A T -- TP YINTI P VE E EP E YPG DLE LE 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 81 RRIRS A IRWNA VMT VLRA S KKDL E LGGH MA SF Q SSATLYEV C FNHFFRA H N NND GGDLVFFQGH I SPGIYARAFLEGRLT 160
Cdd:PRK09405 82 RRIRS Y IRWNA AAM VLRA N KKDL G LGGH IS SF A SSATLYEV G FNHFFRA P N EPH GGDLVFFQGH A SPGIYARAFLEGRLT 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 161 EEQ MN NFRQE IG G N GLSSYPHP K LMPDFWQFPTVSMGLGPI N AIYQA K FLKYL D NRGLKDTS A Q R V Y AFLGDGEMDEPES 240
Cdd:PRK09405 162 EEQ LD NFRQE VD G K GLSSYPHP W LMPDFWQFPTVSMGLGPI M AIYQA R FLKYL E NRGLKDTS D Q K V W AFLGDGEMDEPES 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 241 K GAI TI A T R D KLDNL V FVINCNLQRLDGPV T GNGKI VN ELEGIF N GAGW Q VIKV M WG D RWD E LL R KDTSGKLVQLMNET L 320
Cdd:PRK09405 242 L GAI SL A A R E KLDNL I FVINCNLQRLDGPV R GNGKI IQ ELEGIF R GAGW N VIKV I WG S RWD P LL A KDTSGKLVQLMNET V 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 321 DGDYQT F K SR DGAYVREHFF NR YPET A ALV K DM T DD E IWALNRGGHDP K KVYAA F K K A Q E T KG K PTVILA Q TIKGYGMGE 400
Cdd:PRK09405 322 DGDYQT Y K AK DGAYVREHFF GK YPET K ALV A DM S DD D IWALNRGGHDP R KVYAA Y K A A V E H KG Q PTVILA K TIKGYGMGE 401
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 401 TA EGKNIAHQVKK MNM D GVR HFRD Q FN V P VA DEQ I EKLPY ITFEK DS E E Y KYLHERR Q ALGGYLPARR ST F d E K L DI PAL 480
Cdd:PRK09405 402 AG EGKNIAHQVKK LDL D DLK HFRD R FN I P IS DEQ L EKLPY YKPGE DS P E I KYLHERR K ALGGYLPARR PK F - E P L EV PAL 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 481 AD F SQ LL EEQSK - EISTT I AFVR A LN VM LK NQS I KE R L VPII A DEARTFGMEGLFRQIGIY S P K GQ Q YTP Q DR E Q VA YYK 559
Cdd:PRK09405 481 SA F EA LL KGSGE r EISTT M AFVR I LN IL LK DKE I GK R I VPII P DEARTFGMEGLFRQIGIY N P H GQ L YTP V DR D Q LM YYK 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 560 E DSK GQILQEGINE L GA GS SW L AAATSYST NNL PMIPFYIYYSMFGFQRIGDL M WAAGDQ Q ARGFL I GGT S GRTTLNGEG 639
Cdd:PRK09405 561 E SKD GQILQEGINE A GA MA SW I AAATSYST HGE PMIPFYIYYSMFGFQRIGDL A WAAGDQ R ARGFL L GGT A GRTTLNGEG 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 640 LQHEDGHSHI QSL TIPNC I SYDPAFAYEVAVI M Q N GL E RMYGE k QENV Y YYIT TL NENYH M PAMPEGAEEGI R KG I YKL A 719
Cdd:PRK09405 641 LQHEDGHSHI LAS TIPNC V SYDPAFAYEVAVI V Q D GL R RMYGE - QENV F YYIT VM NENYH Q PAMPEGAEEGI L KG M YKL E 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 720 SV EG S KGK -- VQLLGSG SMM R H V R EAA D IL SAE YG IGS DV Y SVTSF T ELARDGQD C ERWNMLHP S E A PRVPY IA QV MND A 797
Cdd:PRK09405 720 TA EG K KGK pk VQLLGSG TIL R E V L EAA E IL AED YG VAA DV W SVTSF N ELARDGQD V ERWNMLHP T E E PRVPY VT QV LKG A 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 798 -- P A VA S TDYMKLFAEQ V R TY VP A s DY R VLGTDGFGRSD S RE N LR HH FEVD TS YV I VAAL GE LA KR GEID VK VV E EAIKK 875
Cdd:PRK09405 800 eg P V VA A TDYMKLFAEQ I R AF VP G - DY V VLGTDGFGRSD T RE A LR RF FEVD AE YV V VAAL KA LA DE GEID AS VV A EAIKK 878
890
....*....|...
gi 491051468 876 Y N I N PDK V NPR L A 888
Cdd:PRK09405 879 Y G I D PDK A NPR T A 891
Name
Accession
Description
Interval
E-value
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
1-888
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1938.78
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 1 M S DMLK ND V DPIET RD WL Q A IE SVIREEG VD RA QFII EQ V L SE AR KG GV NIA A G A S gh SD YINTI A VE D EP A YPG NMD LE 80
Cdd:PRK09405 4 G S ESQL ND I DPIET QE WL E A LD SVIREEG PE RA HYLL EQ L L ER AR EK GV SLP A S A T -- TP YINTI P VE E EP E YPG DLE LE 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 81 RRIRS A IRWNA VMT VLRA S KKDL E LGGH MA SF Q SSATLYEV C FNHFFRA H N NND GGDLVFFQGH I SPGIYARAFLEGRLT 160
Cdd:PRK09405 82 RRIRS Y IRWNA AAM VLRA N KKDL G LGGH IS SF A SSATLYEV G FNHFFRA P N EPH GGDLVFFQGH A SPGIYARAFLEGRLT 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 161 EEQ MN NFRQE IG G N GLSSYPHP K LMPDFWQFPTVSMGLGPI N AIYQA K FLKYL D NRGLKDTS A Q R V Y AFLGDGEMDEPES 240
Cdd:PRK09405 162 EEQ LD NFRQE VD G K GLSSYPHP W LMPDFWQFPTVSMGLGPI M AIYQA R FLKYL E NRGLKDTS D Q K V W AFLGDGEMDEPES 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 241 K GAI TI A T R D KLDNL V FVINCNLQRLDGPV T GNGKI VN ELEGIF N GAGW Q VIKV M WG D RWD E LL R KDTSGKLVQLMNET L 320
Cdd:PRK09405 242 L GAI SL A A R E KLDNL I FVINCNLQRLDGPV R GNGKI IQ ELEGIF R GAGW N VIKV I WG S RWD P LL A KDTSGKLVQLMNET V 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 321 DGDYQT F K SR DGAYVREHFF NR YPET A ALV K DM T DD E IWALNRGGHDP K KVYAA F K K A Q E T KG K PTVILA Q TIKGYGMGE 400
Cdd:PRK09405 322 DGDYQT Y K AK DGAYVREHFF GK YPET K ALV A DM S DD D IWALNRGGHDP R KVYAA Y K A A V E H KG Q PTVILA K TIKGYGMGE 401
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 401 TA EGKNIAHQVKK MNM D GVR HFRD Q FN V P VA DEQ I EKLPY ITFEK DS E E Y KYLHERR Q ALGGYLPARR ST F d E K L DI PAL 480
Cdd:PRK09405 402 AG EGKNIAHQVKK LDL D DLK HFRD R FN I P IS DEQ L EKLPY YKPGE DS P E I KYLHERR K ALGGYLPARR PK F - E P L EV PAL 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 481 AD F SQ LL EEQSK - EISTT I AFVR A LN VM LK NQS I KE R L VPII A DEARTFGMEGLFRQIGIY S P K GQ Q YTP Q DR E Q VA YYK 559
Cdd:PRK09405 481 SA F EA LL KGSGE r EISTT M AFVR I LN IL LK DKE I GK R I VPII P DEARTFGMEGLFRQIGIY N P H GQ L YTP V DR D Q LM YYK 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 560 E DSK GQILQEGINE L GA GS SW L AAATSYST NNL PMIPFYIYYSMFGFQRIGDL M WAAGDQ Q ARGFL I GGT S GRTTLNGEG 639
Cdd:PRK09405 561 E SKD GQILQEGINE A GA MA SW I AAATSYST HGE PMIPFYIYYSMFGFQRIGDL A WAAGDQ R ARGFL L GGT A GRTTLNGEG 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 640 LQHEDGHSHI QSL TIPNC I SYDPAFAYEVAVI M Q N GL E RMYGE k QENV Y YYIT TL NENYH M PAMPEGAEEGI R KG I YKL A 719
Cdd:PRK09405 641 LQHEDGHSHI LAS TIPNC V SYDPAFAYEVAVI V Q D GL R RMYGE - QENV F YYIT VM NENYH Q PAMPEGAEEGI L KG M YKL E 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 720 SV EG S KGK -- VQLLGSG SMM R H V R EAA D IL SAE YG IGS DV Y SVTSF T ELARDGQD C ERWNMLHP S E A PRVPY IA QV MND A 797
Cdd:PRK09405 720 TA EG K KGK pk VQLLGSG TIL R E V L EAA E IL AED YG VAA DV W SVTSF N ELARDGQD V ERWNMLHP T E E PRVPY VT QV LKG A 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 798 -- P A VA S TDYMKLFAEQ V R TY VP A s DY R VLGTDGFGRSD S RE N LR HH FEVD TS YV I VAAL GE LA KR GEID VK VV E EAIKK 875
Cdd:PRK09405 800 eg P V VA A TDYMKLFAEQ I R AF VP G - DY V VLGTDGFGRSD T RE A LR RF FEVD AE YV V VAAL KA LA DE GEID AS VV A EAIKK 878
890
....*....|...
gi 491051468 876 Y N I N PDK V NPR L A 888
Cdd:PRK09405 879 Y G I D PDK A NPR T A 891
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
1-888
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1897.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 1 MS D ---- MLKN D V DP I ET RD WL QAIES VI R EEG VD RA QFII E QV L SE AR KG GV NIAAG A S gh SD YINTI A VE D EP A YPG N 76
Cdd:COG2609 1 MS M dglp SQLP D I DP Q ET QE WL ESLDA VI E EEG PE RA RYLL E RL L ER AR RS GV GLPFS A T -- TP YINTI P VE Q EP P YPG D 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 77 MD LERRIRS A IRWNA VMT V L RA SK K DLE LGGH MA SF Q S S ATLYEV C FNHFFR AHNNND GGDLV F FQGH I SPGIYARAFLE 156
Cdd:COG2609 79 EE LERRIRS I IRWNA MAM V V RA NR K GGG LGGH IS SF A S A ATLYEV G FNHFFR GPDHPG GGDLV Y FQGH A SPGIYARAFLE 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 157 GRLTEEQ MN NFRQE IG G N GLSSYPHP K LMPDFWQFPTVSMGLGPINAIYQA K F L KYL D NRGLKDTS AQR V Y AFLGDGEMD 236
Cdd:COG2609 159 GRLTEEQ LD NFRQE VD G K GLSSYPHP W LMPDFWQFPTVSMGLGPINAIYQA R F M KYL H NRGLKDTS DRK V W AFLGDGEMD 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 237 EPES K GAI TI A T R D KLDNL V FVINCNLQRLDGPV T GNGKI VN ELEG I F N GAGW Q VIKV M WG DR WD E LL R KDT S G K LV QL M 316
Cdd:COG2609 239 EPES L GAI SL A A R E KLDNL I FVINCNLQRLDGPV R GNGKI IQ ELEG V F R GAGW N VIKV I WG SE WD P LL A KDT D G A LV KR M 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 317 NET L DGDYQT F K SR DGAYVREHFF NR YPE TA ALV K DM T D DE IW A LNRGGHDP K KVYAA F K K A Q E T KG K PTVILA Q TIKGY 396
Cdd:COG2609 319 NET V DGDYQT Y K AK DGAYVREHFF GK YPE LK ALV A DM S D ED IW R LNRGGHDP R KVYAA Y K A A V E H KG Q PTVILA K TIKGY 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 397 GMGE TA EG K NI A HQ V KK MNM D GVRH FRD Q FN V P VA DEQ I E K LPY ITFEK DS E E Y KYLHERR Q ALGGYLP A RR STF d E K L D 476
Cdd:COG2609 399 GMGE AG EG R NI T HQ Q KK LDL D DLKA FRD R FN I P IS DEQ L E E LPY YKPAE DS P E M KYLHERR K ALGGYLP Q RR TKA - E P L E 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 477 I P A L AD F SQ LL E - EQSK EISTT I AFVR A LN VM LK NQS I KE R L VPI IA DEARTFGMEGLFRQIGIYSP K GQ Q YTP Q D RE Q V 555
Cdd:COG2609 478 V P E L SA F AA LL K g SGKR EISTT M AFVR I LN DL LK DKE I GK R I VPI VP DEARTFGMEGLFRQIGIYSP V GQ L YTP V D AD Q L 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 556 A YYKE DSK GQILQEGINE L GA G SSW L AA A TSYST NNL PMIPFYIYYSMFGFQR I GDL M WAAGDQ Q ARGFLIG G T S GRTTL 635
Cdd:COG2609 558 L YYKE SKD GQILQEGINE A GA M SSW I AA G TSYST HGV PMIPFYIYYSMFGFQR V GDL A WAAGDQ R ARGFLIG A T A GRTTL 637
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 636 NGEGLQH E DGHSH IQSL TIPNC I SYDPAFAYE V AVI M Q N GL E RMYGE k QENV Y YYIT TL NENY HM PAMPEG A EEGI R KG I 715
Cdd:COG2609 638 NGEGLQH Q DGHSH LLAS TIPNC V SYDPAFAYE L AVI V Q D GL R RMYGE - QENV F YYIT VM NENY AQ PAMPEG V EEGI L KG M 716
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 716 Y K L ASV EG - S K GK VQLLGSG SMM R H V RE AA DI L SAEY G IGS DV Y SVTSF T EL A RDG Q D C ERWN M LHP S E A PRVPY IA Q VM 794
Cdd:COG2609 717 Y L L KEG EG k G K PR VQLLGSG TIL R E V LA AA EL L AEDW G VAA DV W SVTSF N EL R RDG L D V ERWN L LHP E E E PRVPY VT Q CL 796
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 795 ND A -- P A VA S TDYM KLFAE Q V R TY VP A s D Y R VLGTDGFGRSD S RE N LR HH FEVD TSYVI VAAL GE LA KR G E ID VK VV E EA 872
Cdd:COG2609 797 AG A eg P V VA A TDYM RAVPD Q I R PW VP G - R Y T VLGTDGFGRSD T RE A LR RF FEVD RYSIV VAAL KA LA DE G K ID AS VV A EA 875
890
....*....|....*.
gi 491051468 873 IKKY N I N PDK V NP RL A 888
Cdd:COG2609 876 IKKY G I D PDK P NP LT A 891
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
5-888
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1647.57
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 5 LK NDVDPIET RD WL QAIE SV IR EEG VD RA QFII EQ V L SE AR KG GV N I A AG AS gh S DYINTI A VE DE PAYPG NMD LERRIR 84
Cdd:TIGR00759 2 QP NDVDPIET QE WL ESLD SV LA EEG PA RA RYLL EQ L L EY AR EH GV P I P AG TT -- T DYINTI P VE EQ PAYPG DLE LERRIR 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 85 S A IRWNA VMT VLRA S KKDL E LGGH MASFQ S S ATLYEV C FNHFFR A H NNND GGDLVFFQGH IS PGIYARAFLEGRLTEEQ M 164
Cdd:TIGR00759 80 S I IRWNA IAM VLRA N KKDL G LGGH ISTYA S A ATLYEV G FNHFFR G H SEGG GGDLVFFQGH AA PGIYARAFLEGRLTEEQ L 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 165 N NFRQE IG G N GLSSYPHP K LMPDFWQFPTVSMGLGPINAIYQA K F L KYL D NRGLKDT SA Q R V Y AFLGDGEMDEPESKGAI 244
Cdd:TIGR00759 160 D NFRQE VQ G D GLSSYPHP W LMPDFWQFPTVSMGLGPINAIYQA R F M KYL E NRGLKDT GD Q K V W AFLGDGEMDEPESKGAI 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 245 T I A T R D KLDNL V FVINCNLQRLDGPV T GNGKI VN ELE GI F N GAGW Q VIKV M WG DR WD E LL RK DTSG K LV Q LMNET L DGDY 324
Cdd:TIGR00759 240 T F A A R E KLDNL T FVINCNLQRLDGPV R GNGKI IQ ELE SL F R GAGW N VIKV L WG SE WD A LL AR DTSG V LV K LMNET V DGDY 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 325 QT F K SR DGAYVREHFFNR Y PE TA ALV K DM T D DE IWALNRGGHDP K KVYAA FKK AQE T KG K PTVILA Q TIKGYGMG ET AE G 404
Cdd:TIGR00759 320 QT Y K AK DGAYVREHFFNR T PE LK ALV A DM S D AD IWALNRGGHDP R KVYAA YAA AQE H KG Q PTVILA K TIKGYGMG DA AE S 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 405 K N I AHQVKK MNM D GVRH FRD Q F NV P VA D E Q I E K LPY ITFEKD S E E YK YL HE RRQALGGYLPARR s TF D E K L DI PAL AD F S 484
Cdd:TIGR00759 400 R N T AHQVKK LEV D ALKN FRD R F EL P LS D A Q V E E LPY YHPGEG S P E VR YL LA RRQALGGYLPARR - TF A E H L TV PAL EF F G 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 485 Q LL EEQS - K E I STT I AFVR A LN VM LK NQS I KE R L VPI IA DEARTFGMEGLFRQIGIYSP K GQ Q YTP Q D REQVAY YKE DSK 563
Cdd:TIGR00759 479 A LL KGSG e R E V STT M AFVR I LN KL LK DKE I GK R I VPI VP DEARTFGMEGLFRQIGIYSP H GQ T YTP V D ADSLLA YKE SKD 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 564 GQILQEGINE L GA GS SW L AAATSY S T NNL PMIPFYIYYSMFGFQRIGDL M WAA G DQ Q ARGFL I G G T S GRTTLNGEGLQHE 643
Cdd:TIGR00759 559 GQILQEGINE A GA MA SW I AAATSY A T HGE PMIPFYIYYSMFGFQRIGDL C WAA A DQ R ARGFL L G A T A GRTTLNGEGLQHE 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 644 DGHS HI Q SL TIPNCI S YDPAFAYEVAVIM QN GL E RMYGE k QE N V Y YY I T TL NENY HM P A MPEGAEEGI R KG I Y KLASVEG 723
Cdd:TIGR00759 639 DGHS LL Q AA TIPNCI A YDPAFAYEVAVIM ED GL R RMYGE - QE D V F YY V T VM NENY VQ P P MPEGAEEGI L KG L Y RFETSTE 717
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 724 S K G K -- VQLLGSG SM MR H V R EAA DI L S A EY G IG SDV Y SVTSFTELARDG Q D C ERWN M LHP S E A PRV P Y I AQV M N -- DAP A 799
Cdd:TIGR00759 718 E K A K gh VQLLGSG AI MR A V I EAA QL L A A DW G VA SDV W SVTSFTELARDG H D V ERWN L LHP T E T PRV S Y V AQV L N ea DAP V 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 800 V ASTDY MKL FAEQ V R T YVP A s D Y RV LGTDGFGRSD S RENLRH H FEVD TSY V IV AAL GE LA KR GEID VK VV EE AI K KY N I N 879
Cdd:TIGR00759 798 I ASTDY VRA FAEQ I R P YVP R - K Y VT LGTDGFGRSD T RENLRH F FEVD AKS V VL AAL YA LA DD GEID GD VV AD AI A KY G I D 876
....*....
gi 491051468 880 PDK V NP RLA 888
Cdd:TIGR00759 877 PDK A NP VYR 885
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
78-462
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 740.27
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 78 DL ERRIRS A IRWNA VMT V L RA S KKDL EL GGH M A S F Q S S ATLYEV C FNHFFRA HNNND GGDLV F FQGH I SPGIYARAFLEG 157
Cdd:cd02017 2 EI ERRIRS L IRWNA MAM V H RA N KKDL GI GGH I A T F A S A ATLYEV G FNHFFRA RGEGG GGDLV Y FQGH A SPGIYARAFLEG 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 158 RLTEEQ MN NFRQE I GG N GLSSYPHP K LMPDFW Q FPTVSMGLGPI N AIYQA K F LK YL DN RGLKDTS A Q R V Y AFLGDGEMDE 237
Cdd:cd02017 82 RLTEEQ LD NFRQE V GG G GLSSYPHP W LMPDFW E FPTVSMGLGPI Q AIYQA R F NR YL ED RGLKDTS D Q K V W AFLGDGEMDE 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 238 PES K GAI TI A T R D KLDNL V FV I NCNLQRLDGPV T GNGKI VN ELEGIF N GAGW Q VIKV M WG DR WDELL R KD TS G K L V Q L M N 317
Cdd:cd02017 162 PES L GAI GL A A R E KLDNL I FV V NCNLQRLDGPV R GNGKI IQ ELEGIF R GAGW N VIKV I WG SK WDELL A KD GG G A L R Q R M E 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 318 ET L DGDYQT F K SR DGAYVREHFF NR YPE TA ALV K D MT D DEI WALNRGGHDP K KVYAA F KKA Q E T KGKPTVILA Q TIKGYG 397
Cdd:cd02017 242 ET V DGDYQT L K AK DGAYVREHFF GK YPE LK ALV T D LS D EDL WALNRGGHDP R KVYAA Y KKA V E H KGKPTVILA K TIKGYG 321
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491051468 398 M G ETA EG K N I AHQVKKM NM D GVRHF RD Q F NV PV A DEQ I E KL PY ITFEKD SEE Y KYLHERR Q ALGG 462
Cdd:cd02017 322 L G AAG EG R N H AHQVKKM TE D ELKAL RD R F GI PV S DEQ L E EG PY YKPPEG SEE I KYLHERR H ALGG 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
475-701
1.64e-107
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 330.92
E-value: 1.64e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 475 L D IP A L A D --- F SQ LLEEQSK EISTT I AFVR A LN VML K NQS I KERL VPII A DEARTFGMEG L FRQ I GIY SPK GQ Q Y T P Q D 551
Cdd:pfam17831 1 L E IP D L D D kif A SQ TGGSKGR EISTT M AFVR I LN GLV K DKK I GKQV VPII P DEARTFGMEG M FRQ L GIY TSE GQ K Y E P V D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 552 RE Q VAY Y K ED SK GQIL Q EGI N E L GA G S S W L AAATSYS TN N LPMI PFY I YYSMFGFQRIGDL M WAAGD Q QARGFL I GGT S G 631
Cdd:pfam17831 81 KG Q IMF Y R ED KQ GQIL E EGI S E A GA M S A W I AAATSYS NH N TTLL PFY V YYSMFGFQRIGDL A WAAGD M QARGFL V GGT A G 160
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 632 RTTLNGEGLQH E DGHSHIQ SL TIPNC I SYDP AF A Y EVAVI M Q N GL E RM YGE K q EN VY YY I T TL NENY HM P 701
Cdd:pfam17831 161 RTTLNGEGLQH Q DGHSHIQ AS TIPNC R SYDP TY A H EVAVI V Q D GL K RM FAD K - EN CF YY L T VM NENY EH P 229
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
570-678
9.11e-03
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 37.47
E-value: 9.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 570 GI N E LGAGSSWLAA A TSY stnnlp MI P FYIYYSM F g F Q R - IGDLMW A A gdqqargf LI G GTSGRTTLN G E G LQH EDG HS H 648
Cdd:smart00861 21 GI A E QAMVGFAAGL A LHG ------ LR P VVEIFFT F - F D R a KDQIRS A G -------- AS G NVPVVFRHD G G G GVG EDG PT H 85
90 100 110
....*....|....*....|....*....|....*..
gi 491051468 649 i Q S ------- LT IP NCISYD P AFAY E VAVIMQNGLER 678
Cdd:smart00861 86 - H S iedeall RA IP GLKVVA P SDPA E AKGLLRAAIRD 121
Name
Accession
Description
Interval
E-value
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
1-888
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1938.78
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 1 M S DMLK ND V DPIET RD WL Q A IE SVIREEG VD RA QFII EQ V L SE AR KG GV NIA A G A S gh SD YINTI A VE D EP A YPG NMD LE 80
Cdd:PRK09405 4 G S ESQL ND I DPIET QE WL E A LD SVIREEG PE RA HYLL EQ L L ER AR EK GV SLP A S A T -- TP YINTI P VE E EP E YPG DLE LE 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 81 RRIRS A IRWNA VMT VLRA S KKDL E LGGH MA SF Q SSATLYEV C FNHFFRA H N NND GGDLVFFQGH I SPGIYARAFLEGRLT 160
Cdd:PRK09405 82 RRIRS Y IRWNA AAM VLRA N KKDL G LGGH IS SF A SSATLYEV G FNHFFRA P N EPH GGDLVFFQGH A SPGIYARAFLEGRLT 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 161 EEQ MN NFRQE IG G N GLSSYPHP K LMPDFWQFPTVSMGLGPI N AIYQA K FLKYL D NRGLKDTS A Q R V Y AFLGDGEMDEPES 240
Cdd:PRK09405 162 EEQ LD NFRQE VD G K GLSSYPHP W LMPDFWQFPTVSMGLGPI M AIYQA R FLKYL E NRGLKDTS D Q K V W AFLGDGEMDEPES 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 241 K GAI TI A T R D KLDNL V FVINCNLQRLDGPV T GNGKI VN ELEGIF N GAGW Q VIKV M WG D RWD E LL R KDTSGKLVQLMNET L 320
Cdd:PRK09405 242 L GAI SL A A R E KLDNL I FVINCNLQRLDGPV R GNGKI IQ ELEGIF R GAGW N VIKV I WG S RWD P LL A KDTSGKLVQLMNET V 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 321 DGDYQT F K SR DGAYVREHFF NR YPET A ALV K DM T DD E IWALNRGGHDP K KVYAA F K K A Q E T KG K PTVILA Q TIKGYGMGE 400
Cdd:PRK09405 322 DGDYQT Y K AK DGAYVREHFF GK YPET K ALV A DM S DD D IWALNRGGHDP R KVYAA Y K A A V E H KG Q PTVILA K TIKGYGMGE 401
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 401 TA EGKNIAHQVKK MNM D GVR HFRD Q FN V P VA DEQ I EKLPY ITFEK DS E E Y KYLHERR Q ALGGYLPARR ST F d E K L DI PAL 480
Cdd:PRK09405 402 AG EGKNIAHQVKK LDL D DLK HFRD R FN I P IS DEQ L EKLPY YKPGE DS P E I KYLHERR K ALGGYLPARR PK F - E P L EV PAL 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 481 AD F SQ LL EEQSK - EISTT I AFVR A LN VM LK NQS I KE R L VPII A DEARTFGMEGLFRQIGIY S P K GQ Q YTP Q DR E Q VA YYK 559
Cdd:PRK09405 481 SA F EA LL KGSGE r EISTT M AFVR I LN IL LK DKE I GK R I VPII P DEARTFGMEGLFRQIGIY N P H GQ L YTP V DR D Q LM YYK 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 560 E DSK GQILQEGINE L GA GS SW L AAATSYST NNL PMIPFYIYYSMFGFQRIGDL M WAAGDQ Q ARGFL I GGT S GRTTLNGEG 639
Cdd:PRK09405 561 E SKD GQILQEGINE A GA MA SW I AAATSYST HGE PMIPFYIYYSMFGFQRIGDL A WAAGDQ R ARGFL L GGT A GRTTLNGEG 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 640 LQHEDGHSHI QSL TIPNC I SYDPAFAYEVAVI M Q N GL E RMYGE k QENV Y YYIT TL NENYH M PAMPEGAEEGI R KG I YKL A 719
Cdd:PRK09405 641 LQHEDGHSHI LAS TIPNC V SYDPAFAYEVAVI V Q D GL R RMYGE - QENV F YYIT VM NENYH Q PAMPEGAEEGI L KG M YKL E 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 720 SV EG S KGK -- VQLLGSG SMM R H V R EAA D IL SAE YG IGS DV Y SVTSF T ELARDGQD C ERWNMLHP S E A PRVPY IA QV MND A 797
Cdd:PRK09405 720 TA EG K KGK pk VQLLGSG TIL R E V L EAA E IL AED YG VAA DV W SVTSF N ELARDGQD V ERWNMLHP T E E PRVPY VT QV LKG A 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 798 -- P A VA S TDYMKLFAEQ V R TY VP A s DY R VLGTDGFGRSD S RE N LR HH FEVD TS YV I VAAL GE LA KR GEID VK VV E EAIKK 875
Cdd:PRK09405 800 eg P V VA A TDYMKLFAEQ I R AF VP G - DY V VLGTDGFGRSD T RE A LR RF FEVD AE YV V VAAL KA LA DE GEID AS VV A EAIKK 878
890
....*....|...
gi 491051468 876 Y N I N PDK V NPR L A 888
Cdd:PRK09405 879 Y G I D PDK A NPR T A 891
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
1-888
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1897.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 1 MS D ---- MLKN D V DP I ET RD WL QAIES VI R EEG VD RA QFII E QV L SE AR KG GV NIAAG A S gh SD YINTI A VE D EP A YPG N 76
Cdd:COG2609 1 MS M dglp SQLP D I DP Q ET QE WL ESLDA VI E EEG PE RA RYLL E RL L ER AR RS GV GLPFS A T -- TP YINTI P VE Q EP P YPG D 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 77 MD LERRIRS A IRWNA VMT V L RA SK K DLE LGGH MA SF Q S S ATLYEV C FNHFFR AHNNND GGDLV F FQGH I SPGIYARAFLE 156
Cdd:COG2609 79 EE LERRIRS I IRWNA MAM V V RA NR K GGG LGGH IS SF A S A ATLYEV G FNHFFR GPDHPG GGDLV Y FQGH A SPGIYARAFLE 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 157 GRLTEEQ MN NFRQE IG G N GLSSYPHP K LMPDFWQFPTVSMGLGPINAIYQA K F L KYL D NRGLKDTS AQR V Y AFLGDGEMD 236
Cdd:COG2609 159 GRLTEEQ LD NFRQE VD G K GLSSYPHP W LMPDFWQFPTVSMGLGPINAIYQA R F M KYL H NRGLKDTS DRK V W AFLGDGEMD 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 237 EPES K GAI TI A T R D KLDNL V FVINCNLQRLDGPV T GNGKI VN ELEG I F N GAGW Q VIKV M WG DR WD E LL R KDT S G K LV QL M 316
Cdd:COG2609 239 EPES L GAI SL A A R E KLDNL I FVINCNLQRLDGPV R GNGKI IQ ELEG V F R GAGW N VIKV I WG SE WD P LL A KDT D G A LV KR M 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 317 NET L DGDYQT F K SR DGAYVREHFF NR YPE TA ALV K DM T D DE IW A LNRGGHDP K KVYAA F K K A Q E T KG K PTVILA Q TIKGY 396
Cdd:COG2609 319 NET V DGDYQT Y K AK DGAYVREHFF GK YPE LK ALV A DM S D ED IW R LNRGGHDP R KVYAA Y K A A V E H KG Q PTVILA K TIKGY 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 397 GMGE TA EG K NI A HQ V KK MNM D GVRH FRD Q FN V P VA DEQ I E K LPY ITFEK DS E E Y KYLHERR Q ALGGYLP A RR STF d E K L D 476
Cdd:COG2609 399 GMGE AG EG R NI T HQ Q KK LDL D DLKA FRD R FN I P IS DEQ L E E LPY YKPAE DS P E M KYLHERR K ALGGYLP Q RR TKA - E P L E 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 477 I P A L AD F SQ LL E - EQSK EISTT I AFVR A LN VM LK NQS I KE R L VPI IA DEARTFGMEGLFRQIGIYSP K GQ Q YTP Q D RE Q V 555
Cdd:COG2609 478 V P E L SA F AA LL K g SGKR EISTT M AFVR I LN DL LK DKE I GK R I VPI VP DEARTFGMEGLFRQIGIYSP V GQ L YTP V D AD Q L 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 556 A YYKE DSK GQILQEGINE L GA G SSW L AA A TSYST NNL PMIPFYIYYSMFGFQR I GDL M WAAGDQ Q ARGFLIG G T S GRTTL 635
Cdd:COG2609 558 L YYKE SKD GQILQEGINE A GA M SSW I AA G TSYST HGV PMIPFYIYYSMFGFQR V GDL A WAAGDQ R ARGFLIG A T A GRTTL 637
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 636 NGEGLQH E DGHSH IQSL TIPNC I SYDPAFAYE V AVI M Q N GL E RMYGE k QENV Y YYIT TL NENY HM PAMPEG A EEGI R KG I 715
Cdd:COG2609 638 NGEGLQH Q DGHSH LLAS TIPNC V SYDPAFAYE L AVI V Q D GL R RMYGE - QENV F YYIT VM NENY AQ PAMPEG V EEGI L KG M 716
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 716 Y K L ASV EG - S K GK VQLLGSG SMM R H V RE AA DI L SAEY G IGS DV Y SVTSF T EL A RDG Q D C ERWN M LHP S E A PRVPY IA Q VM 794
Cdd:COG2609 717 Y L L KEG EG k G K PR VQLLGSG TIL R E V LA AA EL L AEDW G VAA DV W SVTSF N EL R RDG L D V ERWN L LHP E E E PRVPY VT Q CL 796
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 795 ND A -- P A VA S TDYM KLFAE Q V R TY VP A s D Y R VLGTDGFGRSD S RE N LR HH FEVD TSYVI VAAL GE LA KR G E ID VK VV E EA 872
Cdd:COG2609 797 AG A eg P V VA A TDYM RAVPD Q I R PW VP G - R Y T VLGTDGFGRSD T RE A LR RF FEVD RYSIV VAAL KA LA DE G K ID AS VV A EA 875
890
....*....|....*.
gi 491051468 873 IKKY N I N PDK V NP RL A 888
Cdd:COG2609 876 IKKY G I D PDK P NP LT A 891
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
5-888
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1647.57
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 5 LK NDVDPIET RD WL QAIE SV IR EEG VD RA QFII EQ V L SE AR KG GV N I A AG AS gh S DYINTI A VE DE PAYPG NMD LERRIR 84
Cdd:TIGR00759 2 QP NDVDPIET QE WL ESLD SV LA EEG PA RA RYLL EQ L L EY AR EH GV P I P AG TT -- T DYINTI P VE EQ PAYPG DLE LERRIR 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 85 S A IRWNA VMT VLRA S KKDL E LGGH MASFQ S S ATLYEV C FNHFFR A H NNND GGDLVFFQGH IS PGIYARAFLEGRLTEEQ M 164
Cdd:TIGR00759 80 S I IRWNA IAM VLRA N KKDL G LGGH ISTYA S A ATLYEV G FNHFFR G H SEGG GGDLVFFQGH AA PGIYARAFLEGRLTEEQ L 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 165 N NFRQE IG G N GLSSYPHP K LMPDFWQFPTVSMGLGPINAIYQA K F L KYL D NRGLKDT SA Q R V Y AFLGDGEMDEPESKGAI 244
Cdd:TIGR00759 160 D NFRQE VQ G D GLSSYPHP W LMPDFWQFPTVSMGLGPINAIYQA R F M KYL E NRGLKDT GD Q K V W AFLGDGEMDEPESKGAI 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 245 T I A T R D KLDNL V FVINCNLQRLDGPV T GNGKI VN ELE GI F N GAGW Q VIKV M WG DR WD E LL RK DTSG K LV Q LMNET L DGDY 324
Cdd:TIGR00759 240 T F A A R E KLDNL T FVINCNLQRLDGPV R GNGKI IQ ELE SL F R GAGW N VIKV L WG SE WD A LL AR DTSG V LV K LMNET V DGDY 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 325 QT F K SR DGAYVREHFFNR Y PE TA ALV K DM T D DE IWALNRGGHDP K KVYAA FKK AQE T KG K PTVILA Q TIKGYGMG ET AE G 404
Cdd:TIGR00759 320 QT Y K AK DGAYVREHFFNR T PE LK ALV A DM S D AD IWALNRGGHDP R KVYAA YAA AQE H KG Q PTVILA K TIKGYGMG DA AE S 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 405 K N I AHQVKK MNM D GVRH FRD Q F NV P VA D E Q I E K LPY ITFEKD S E E YK YL HE RRQALGGYLPARR s TF D E K L DI PAL AD F S 484
Cdd:TIGR00759 400 R N T AHQVKK LEV D ALKN FRD R F EL P LS D A Q V E E LPY YHPGEG S P E VR YL LA RRQALGGYLPARR - TF A E H L TV PAL EF F G 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 485 Q LL EEQS - K E I STT I AFVR A LN VM LK NQS I KE R L VPI IA DEARTFGMEGLFRQIGIYSP K GQ Q YTP Q D REQVAY YKE DSK 563
Cdd:TIGR00759 479 A LL KGSG e R E V STT M AFVR I LN KL LK DKE I GK R I VPI VP DEARTFGMEGLFRQIGIYSP H GQ T YTP V D ADSLLA YKE SKD 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 564 GQILQEGINE L GA GS SW L AAATSY S T NNL PMIPFYIYYSMFGFQRIGDL M WAA G DQ Q ARGFL I G G T S GRTTLNGEGLQHE 643
Cdd:TIGR00759 559 GQILQEGINE A GA MA SW I AAATSY A T HGE PMIPFYIYYSMFGFQRIGDL C WAA A DQ R ARGFL L G A T A GRTTLNGEGLQHE 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 644 DGHS HI Q SL TIPNCI S YDPAFAYEVAVIM QN GL E RMYGE k QE N V Y YY I T TL NENY HM P A MPEGAEEGI R KG I Y KLASVEG 723
Cdd:TIGR00759 639 DGHS LL Q AA TIPNCI A YDPAFAYEVAVIM ED GL R RMYGE - QE D V F YY V T VM NENY VQ P P MPEGAEEGI L KG L Y RFETSTE 717
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 724 S K G K -- VQLLGSG SM MR H V R EAA DI L S A EY G IG SDV Y SVTSFTELARDG Q D C ERWN M LHP S E A PRV P Y I AQV M N -- DAP A 799
Cdd:TIGR00759 718 E K A K gh VQLLGSG AI MR A V I EAA QL L A A DW G VA SDV W SVTSFTELARDG H D V ERWN L LHP T E T PRV S Y V AQV L N ea DAP V 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 800 V ASTDY MKL FAEQ V R T YVP A s D Y RV LGTDGFGRSD S RENLRH H FEVD TSY V IV AAL GE LA KR GEID VK VV EE AI K KY N I N 879
Cdd:TIGR00759 798 I ASTDY VRA FAEQ I R P YVP R - K Y VT LGTDGFGRSD T RENLRH F FEVD AKS V VL AAL YA LA DD GEID GD VV AD AI A KY G I D 876
....*....
gi 491051468 880 PDK V NP RLA 888
Cdd:TIGR00759 877 PDK A NP VYR 885
PRK13012
PRK13012 2-oxoacid dehydrogenase subunit E1; Provisional
7-885
0e+00
2-oxoacid dehydrogenase subunit E1; Provisional
Pssm-ID: 237267 [Multi-domain]
Cd Length: 896
Bit Score: 1503.68
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 7 N D V DP I ET RD WL Q A IES V IREE G VD RA QFIIEQV L SE A RKG G VNIAAGAS gh SD Y I NTI A V EDE P A YPG NMD LE R R IRSA 86
Cdd:PRK13012 18 P D I DP Q ET AE WL E A LDA V VAHA G PE RA RYLLDRL L ER A AAR G IALPGLLT -- TP Y V NTI P V DQQ P P YPG DLA LE E R LAAI 95
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 87 IRWNA VMT V L RA SKKDL ELGGH M AS FQ S S A T L Y EV C FNHFFR AHNNND GGDLV F FQ G H IS PGIYARAFLEGRL T EEQ MNN 166
Cdd:PRK13012 96 IRWNA LAM V V RA NRAYG ELGGH I AS YA S A A D L F EV G FNHFFR GRDDAG GGDLV Y FQ P H SA PGIYARAFLEGRL S EEQ LDH 175
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 167 FRQEIGG N GLSSYPHP K LMPDFWQFPT V SMG L GPINAIYQA K F LK YL DN RGLKDTS AQR V YA F L GDGEMDEPES KG A ITI 246
Cdd:PRK13012 176 FRQEIGG P GLSSYPHP W LMPDFWQFPT G SMG I GPINAIYQA R F MR YL QH RGLKDTS GRK V WG F F GDGEMDEPES IA A LSL 255
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 247 A T R DK LDNLVFVINCNLQRLDGPV T GNG K I VN ELE GI F N GAGW Q VIKV M WG DR WD E L LRK DT S G K LV QLMN ET L DG DY QT 326
Cdd:PRK13012 256 A A R EG LDNLVFVINCNLQRLDGPV R GNG R I IQ ELE AL F R GAGW N VIKV L WG SD WD A L FAR DT T G A LV RRFA ET V DG QF QT 335
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 327 FK SR DGAY V REHFF NRY PE T AALV KDMT D DE I WA L N RGGHDP K KVYAA FKK A QET KG K PTVILA Q T I KGYGMGE TA EG KN 406
Cdd:PRK13012 336 FK AN DGAY N REHFF GQD PE L AALV AHLS D ED I DR L K RGGHDP R KVYAA YAA A VRH KG Q PTVILA K T K KGYGMGE AG EG RM 415
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 407 IA HQ V KK MNMDGVRH FRD Q F NV P VA DEQ I E K LP YITFEK DS E E YK YLH E RR Q ALGGYLP A RR ST f DEK L DI P A L AD F S Q - 485
Cdd:PRK13012 416 TT HQ Q KK LDVEALKA FRD R F RL P LS DEQ L E Q LP FYKPAE DS P E MR YLH A RR A ALGGYLP R RR TA - APP L PV P P L SA F A Q f 494
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 486 L L EEQS KE I STT I AFVR A L NVM LK NQSIKE R L VPI I ADEARTFGM EG LFRQ I GIYSP K GQ Q Y T P Q D REQVA YY K E DSK GQ 565
Cdd:PRK13012 495 A L GAGG KE M STT M AFVR M L GNL LK DKALGP R I VPI V ADEARTFGM AN LFRQ V GIYSP L GQ L Y E P E D AGSLL YY R E AKD GQ 574
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 566 IL Q EGI N E L GA G SSW L AAATSYS TNN LPM I PFYIYYSMFGFQR I GDL M WAA G DQ Q ARGFL I G G T S GRTTL N GEGLQH E DG 645
Cdd:PRK13012 575 IL E EGI T E A GA I SSW I AAATSYS VHG LPM L PFYIYYSMFGFQR V GDL I WAA A DQ R ARGFL L G A T A GRTTL G GEGLQH Q DG 654
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 646 HSH IQSL TIPNC IS YDPAFAYE V AVI MQN G LE RM YG E k QE N V Y YY I T TL NENY HM PA M PEGAEEGI R KG I Y K LA S v EGSK 725
Cdd:PRK13012 655 HSH LLAS TIPNC RA YDPAFAYE L AVI VDD G MR RM LE E - QE D V F YY L T VM NENY AQ PA L PEGAEEGI L KG M Y R LA A - AAEA 732
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 726 GK VQLLGSG SMM R H V RE AA DI L SAEY G IGS DV Y SVTSFTEL A RDG QDC ER W N M L H P S E AP RVPY IA Q VMNDA -- P A VA S T 803
Cdd:PRK13012 733 PR VQLLGSG AIL R E V LA AA RL L ADDW G VDA DV W SVTSFTEL R RDG LAA ER A N L L G P A E EA RVPY VT Q CLAGT rg P V VA A T 812
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 804 DY MKLFA EQ V R TY VPA s D Y RV LGTDGFGRSD S R EN LR HH FEVD TSYVIV AAL GE LA KR GE IDVK VV E EAI KK Y N I NP DK V 883
Cdd:PRK13012 813 DY VRAVP EQ I R AF VPA - R Y VT LGTDGFGRSD T R AA LR RF FEVD RHSIVL AAL KA LA DD GE VERT VV A EAI ER Y G I DD DK T 891
..
gi 491051468 884 N P 885
Cdd:PRK13012 892 P P 893
AKGDH_not_PDH
TIGR03186 alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric ...
6-876
0e+00
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric form of the pyruvate dehydrogenase E1 component (see model TIGR00759), often encoded next to L-methionine gamma-lyase gene (mdeA). The member from a strain of Pseudomonas putida was shown to act on alpha-ketobutyrate, which is produced by MdeA.This model serves as an exception model to TIGR00759, as other proteins hitting TIGR00759 should be identified as the pyruvate dehydrogenase E1 component.
Pssm-ID: 132230 [Multi-domain]
Cd Length: 889
Bit Score: 1137.68
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 6 KN D V DP I ET RD WL Q A IES V IREE G VD RAQ FIIE Q VLSE A RKG G vn I A AG A S G HSD Y I NTIAV ED EP A YPG NMD LE R R IRS 85
Cdd:TIGR03186 3 HD D T DP Q ET AE WL D A LDG V VAHA G AE RAQ YLLA Q LAAH A ARL G -- L A PP A A G ATP Y V NTIAV DQ EP P YPG DLQ LE E R LAA 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 86 AI RWNA VMT V L RA SKKDL ELGGH M AS FQ S S A T L Y EV C FNHFFRA HNNND GGDLV F FQ G H IS PG I YARAFLEG R L TEE Q MN 165
Cdd:TIGR03186 81 IL RWNA LAM V V RA NRAYG ELGGH I AS YA S A A D L F EV G FNHFFRA AGDAS GGDLV Y FQ P H SA PG V YARAFLEG F L SDA Q LA 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 166 NF RQEI G G N GL S SYPHP K LMPDFWQFPT V SMG L GPINAIYQA K F LK YL D NRGL KD T SAQR V YA F L GDGEMDEPES K GA IT 245
Cdd:TIGR03186 161 HY RQEI A G P GL C SYPHP W LMPDFWQFPT G SMG I GPINAIYQA R F MR YL Q NRGL AR T EGRK V WG F F GDGEMDEPES I GA LS 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 246 I A T R DK LDNLVFVINCNLQRLDGPV T GNG K I VN ELE GI F N GAGW Q VIKV M WG DR WD E L LRK D TS G K L VQLMNE T L DG DY Q 325
Cdd:TIGR03186 241 L A A R ER LDNLVFVINCNLQRLDGPV R GNG R I ID ELE SQ F A GAGW N VIKV L WG SD WD A L FAR D AT G A L ARAFAH T V DG QF Q 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 326 TF KSR DGAY V R EH FF NRY P ET AALV KDMT D DE I WA L N RGGHD PK K V YAA FKK A QETK G K PTVILA Q T I KG Y GMG ETAE G K 405
Cdd:TIGR03186 321 TF SAN DGAY N R AR FF GQD P AL AALV AHLS D ED I DR L R RGGHD AR K L YAA YDR A VRHE G R PTVILA K T M KG F GMG AIGQ G R 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 406 NIA HQ V KK MNMDGVRH FRD Q F NV P VA D EQI E K L PYITFEK DS E E YK YLH E RR Q ALGGYLP A RR STFDEK L DI PAL ADFSQ 485
Cdd:TIGR03186 401 MTT HQ Q KK LDVEALLA FRD R F RL P LS D ADV E Q L KFYKPDE DS A E MR YLH A RR A ALGGYLP R RR TAATHA L AV PAL PSWGR 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 486 L - L EEQS KE I STT I A F VR A L NVM LK NQSIKE R L VPI I ADEARTFGM EG LFRQ I GIYSP K GQ Q Y T P Q D REQVA YY K ED SK G 564
Cdd:TIGR03186 481 F a L DAEG KE M STT M A I VR M L GAL LK DAELGP R I VPI V ADEARTFGM AN LFRQ V GIYSP L GQ R Y E P E D LGSML YY R ED TD G 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 565 QIL Q EGI N E L GA G SSW L AAATSYS TNN LPM I PFYIYYSMFGFQRIGDL M WAA G DQ Q ARGFLIG G TSG R TTL N GEGLQH E D 644
Cdd:TIGR03186 561 QIL E EGI S E A GA I SSW I AAATSYS VHD LPM L PFYIYYSMFGFQRIGDL I WAA A DQ R ARGFLIG A TSG K TTL G GEGLQH Q D 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 645 G H SH IQSL T I PNC ISY DPAFAYEVAVI MQN G LER M Y g E K Q ENVY YY I T TL NENY HM P AM PE GAEEGI R K GI Y K ---- L AS 720
Cdd:TIGR03186 641 G T SH LAAS T V PNC RAW DPAFAYEVAVI VDE G MRE M L - E R Q RDEF YY L T VT NENY AQ P SL PE DRLDAV R R GI L K gmyp L DP 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 721 VEGSKGK VQLLGSG SMMRH V RE AA DI L SAEY GI GSD V Y SVTSFTELARDG QDC ER WNM L HPS E A P RV P YI AQ VM -- NDA P 798
Cdd:TIGR03186 720 AALAAAR VQLLGSG AILGE V QA AA RL L RDDW GI DAA V W SVTSFTELARDG RAA ER AQR L GDA E R P PS P HV AQ AL ga TQG P 799
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491051468 799 AV A S TDY MKLFA E QV R T YVP AS d Y RV LGTDGFGRSD S R EN LR HH FEVD TSYVIV AAL GE LA KR G EIDVK VV EE AI KK Y 876
Cdd:TIGR03186 800 VI A A TDY VRAVP E LI R A YVP RR - Y VT LGTDGFGRSD T R AA LR AF FEVD RASIVI AAL QA LA DD G LVARD VV RQ AI AR Y 876
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
78-462
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 740.27
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 78 DL ERRIRS A IRWNA VMT V L RA S KKDL EL GGH M A S F Q S S ATLYEV C FNHFFRA HNNND GGDLV F FQGH I SPGIYARAFLEG 157
Cdd:cd02017 2 EI ERRIRS L IRWNA MAM V H RA N KKDL GI GGH I A T F A S A ATLYEV G FNHFFRA RGEGG GGDLV Y FQGH A SPGIYARAFLEG 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 158 RLTEEQ MN NFRQE I GG N GLSSYPHP K LMPDFW Q FPTVSMGLGPI N AIYQA K F LK YL DN RGLKDTS A Q R V Y AFLGDGEMDE 237
Cdd:cd02017 82 RLTEEQ LD NFRQE V GG G GLSSYPHP W LMPDFW E FPTVSMGLGPI Q AIYQA R F NR YL ED RGLKDTS D Q K V W AFLGDGEMDE 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 238 PES K GAI TI A T R D KLDNL V FV I NCNLQRLDGPV T GNGKI VN ELEGIF N GAGW Q VIKV M WG DR WDELL R KD TS G K L V Q L M N 317
Cdd:cd02017 162 PES L GAI GL A A R E KLDNL I FV V NCNLQRLDGPV R GNGKI IQ ELEGIF R GAGW N VIKV I WG SK WDELL A KD GG G A L R Q R M E 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 318 ET L DGDYQT F K SR DGAYVREHFF NR YPE TA ALV K D MT D DEI WALNRGGHDP K KVYAA F KKA Q E T KGKPTVILA Q TIKGYG 397
Cdd:cd02017 242 ET V DGDYQT L K AK DGAYVREHFF GK YPE LK ALV T D LS D EDL WALNRGGHDP R KVYAA Y KKA V E H KGKPTVILA K TIKGYG 321
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491051468 398 M G ETA EG K N I AHQVKKM NM D GVRHF RD Q F NV PV A DEQ I E KL PY ITFEKD SEE Y KYLHERR Q ALGG 462
Cdd:cd02017 322 L G AAG EG R N H AHQVKKM TE D ELKAL RD R F GI PV S DEQ L E EG PY YKPPEG SEE I KYLHERR H ALGG 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
475-701
1.64e-107
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 330.92
E-value: 1.64e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 475 L D IP A L A D --- F SQ LLEEQSK EISTT I AFVR A LN VML K NQS I KERL VPII A DEARTFGMEG L FRQ I GIY SPK GQ Q Y T P Q D 551
Cdd:pfam17831 1 L E IP D L D D kif A SQ TGGSKGR EISTT M AFVR I LN GLV K DKK I GKQV VPII P DEARTFGMEG M FRQ L GIY TSE GQ K Y E P V D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 552 RE Q VAY Y K ED SK GQIL Q EGI N E L GA G S S W L AAATSYS TN N LPMI PFY I YYSMFGFQRIGDL M WAAGD Q QARGFL I GGT S G 631
Cdd:pfam17831 81 KG Q IMF Y R ED KQ GQIL E EGI S E A GA M S A W I AAATSYS NH N TTLL PFY V YYSMFGFQRIGDL A WAAGD M QARGFL V GGT A G 160
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 632 RTTLNGEGLQH E DGHSHIQ SL TIPNC I SYDP AF A Y EVAVI M Q N GL E RM YGE K q EN VY YY I T TL NENY HM P 701
Cdd:pfam17831 161 RTTLNGEGLQH Q DGHSHIQ AS TIPNC R SYDP TY A H EVAVI V Q D GL K RM FAD K - EN CF YY L T VM NENY EH P 229
TPP_TK
cd02012 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK ...
86-409
5.90e-24
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.
Pssm-ID: 238970 [Multi-domain]
Cd Length: 255
Bit Score: 101.81
E-value: 5.90e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 86 A IR WNAVMT V LR A S kkdlel G GH MASFQ S S A TLYE V CFNHFFR a HNNN D GGDL --- V F FQ -- GH I SP GI YA RAF L E G R L T 160
Cdd:cd02012 2 R IR RLSIDM V QK A G ------ S GH PGGSL S A A DILA V LYFKVLK - YDPA D PKWP nrd R F VL sk GH A SP AL YA VLA L A G Y L P 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 161 EE QMNN FRQ e I G gngl S SY P - HP - KLMPDFWQFP T V S M G L G PIN A I --- YQA K F L K yldnrglkdt SAQ RVY AF LGDGE M 235
Cdd:cd02012 75 EE DLKT FRQ - L G ---- S RL P g HP e YGLTPGVEVT T G S L G Q G LSV A V gma LAE K L L G ---------- FDY RVY VL LGDGE L 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 236 D E PESKG A ITI A TRD KLDNL VFVINC N LQRL DGP v T GNGKIVNE L EGI F NGA GW Q VI K V mwgdrwdellrkdtsgklvql 315
Cdd:cd02012 140 Q E GSVWE A ASF A GHY KLDNL IAIVDS N RIQI DGP - T DDILFTED L AKK F EAF GW N VI E V --------------------- 197
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 316 mnetldgdyqtfksrdgayvrehffnrypetaalvkdmtddeiwalnr G GHD PKKVY AA FKK A QET KGKPT V I L A Q TIKG 395
Cdd:cd02012 198 ------------------------------------------------ D GHD VEEIL AA LEE A KKS KGKPT L I I A K TIKG 229
330
....*....|....
gi 491051468 396 Y G M g ETA E GKNIA H 409
Cdd:cd02012 230 K G V - PFM E NTAKW H 242
PRK05899
PRK05899 transketolase; Reviewed
76-858
8.95e-22
transketolase; Reviewed
Pssm-ID: 235639 [Multi-domain]
Cd Length: 586
Bit Score: 100.59
E-value: 8.95e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 76 N M D L ERRIRS AIR WNAVMT V LR A S kkdlel G GH MASFQSS A TLYE V CFNH F F R a H N ------- N N D gg DL V FFQ GH I S PG 148
Cdd:PRK05899 4 D M E L LQLLAN AIR VLSIDA V QK A N ------ S GH PGMPMGA A DIAY V LWTR F L R - H D pknpkwp N R D -- RF V LSA GH G S ML 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 149 I Y ARAF L E G - R L TEEQMN NFRQ e I G gngl S SY P - HP klmp DFWQF P T V SMGL GP I ----- NA I --- YQA K F L KY L D NR GL 218
Cdd:PRK05899 75 L Y SLLH L A G y D L SIDDLK NFRQ - L G ---- S KT P g HP ---- EYGHT P G V ETTT GP L gqgla NA V gma LAE K Y L AA L F NR PG 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 219 K D TSAQRV Y AFL GDG EMD E PE S KG A ITI A TRD KL D NL VFVINC N - LQ r L DGP VT G ngk IVN E - LEGI F NGA GW Q VI K V mw 296
Cdd:PRK05899 146 L D IVDHYT Y VLC GDG DLM E GI S HE A CSL A GHL KL G NL IVIYDD N r IS - I DGP TE G --- WFT E d VKKR F EAY GW H VI E V -- 219
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 297 g D rwdellrkdtsgklvqlmnetldgdyqtfksrdgayvrehffnrypetaalvkdmtddeiwalnrg GHD PKKVY AA FK 376
Cdd:PRK05899 220 - D ------------------------------------------------------------------ GHD VEAID AA IE 232
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 377 K A QETK g KPT V I L A Q TI K G Y G MG e TA EG KNIA H qvkkmnmd G vrhfrdqfn V P VAD E Q I EKL pyitfekdseeykylher 456
Cdd:PRK05899 233 E A KAST - KPT L I I A K TI I G K G AP - NK EG THKV H -------- G --------- A P LGA E E I AAA ------------------ 275
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 457 RQA LG G ylp AR R STFDE kldip AL ADFSQL L E E qskeisttia F V r ALNVM L KN q S IK erlvpiiade ARTF G MEGLF rq 536
Cdd:PRK05899 276 KKE LG W --- DY R KASGK ----- AL NALAKA L P E ---------- L V - GGSAD L AG - S NN ---------- TKIK G SKDFA -- 323
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 537 igiyspkgqqytpqdreqvayy K ED SK G QILQE G IN E LGAG sswl A A A TSYSTNN l PM IPF --------- Y iyys MFGFQ 607
Cdd:PRK05899 324 ---------------------- P ED YS G RYIHY G VR E FAMA ---- A I A NGLALHG - GF IPF ggtflvfsd Y ---- ARNAI 372
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 608 R IGD LM waagdq QARGFLIG gtsgrt T LNGE G LQ h EDG HS H ----- IQ SL - T IPN CISYD PA F A Y E V A VIMQNG LER MY G 681
Cdd:PRK05899 373 R LAA LM ------ KLPVIYVF ------ T HDSI G VG - EDG PT H qpveq LA SL r A IPN LTVIR PA D A N E T A AAWKYA LER KD G 439
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 682 ekqe NVYYYI T TL N enyh M P AMP - EGA EEG IR KG I Y K L A sveg SKGK V Q L LGS GS MMRHVR EAAD I L S AE y GI GSD V Y S V 760
Cdd:PRK05899 440 ---- PSALVL T RQ N ---- L P VLE r TAQ EEG VA KG G Y V L R ---- DDPD V I L IAT GS EVHLAL EAAD E L E AE - GI KVR V V S M 506
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 761 T S FTELAR dg QD CE - RWNM L HPSEAP RV pyiaqvmndap AV -- AST D YMKLFA eqvrtyvp AS D YR VLG T D G FG R S DSRE 837
Cdd:PRK05899 507 P S TELFDE -- QD AA y KESV L PAAVTA RV ----------- AV ea GVA D GWYKYV -------- GL D GK VLG I D T FG A S APAD 565
810 820
....*....|....*....|.
gi 491051468 838 N L RHH F EVDTSYVIV AA LGE L 858
Cdd:PRK05899 566 E L FKE F GFTVENIVA AA KEL L 586
Transketolase_N
pfam00456 Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes ...
80-409
2.94e-11
Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.
Pssm-ID: 395366 [Multi-domain]
Cd Length: 334
Bit Score: 65.87
E-value: 2.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 80 ER R IRS AIR WN A VMT V LR A S kkdlel G GH MASFQSS A TLY EV C F NH F FR a HN N ND ---- GG D - L V FFQ GH I S PGI Y ARAF 154
Cdd:pfam00456 2 DK R AVN AIR AL A MDA V EK A N ------ S GH PGAPMGM A PIA EV L F KR F LK - HN P ND pkwi NR D r F V LSN GH G S MLL Y SLLH 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 155 L E G - R L TE E QMNN FRQ e I G gngl S SY P - HP klmp D F WQFPT V SMGL GP IN --------- AI YQ a KF L KYLD NR GLK D TSA 223
Cdd:pfam00456 75 L T G y D L SM E DLKS FRQ - L G ---- S KT P g HP ---- E F GHTAG V EVTT GP LG qgianavgm AI AE - RN L AATY NR PGF D IVD 144
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 224 QRV Y A FLGDG EMD E PE S KG A ITI A TRDK L D NL VFVINC N LQRL DG PV tg NGKIVNELEGI F NGA GW Q VI K V mwgdrwdel 303
Cdd:pfam00456 145 HYT Y V FLGDG CLM E GV S SE A SSL A GHLG L G NL IVFYDD N QISI DG ET -- KISFTEDTAAR F EAY GW H VI E V --------- 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 304 lrkdtsgklvqlmnetldgdyqtfksrdgayvrehffnrypetaalvkdmtddeiwaln RG GHD PKKVY AA FKK A QET K G 383
Cdd:pfam00456 214 ----------------------------------------------------------- ED GHD VEAIA AA IEE A KAE K D 234
330 340
....*....|....*....|....*.
gi 491051468 384 KPT V I LAQ T IK GYG m GETAE G KNIA H 409
Cdd:pfam00456 235 KPT L I KCR T VI GYG - SPNKQ G THDV H 259
PTZ00089
PTZ00089 transketolase; Provisional
76-750
9.57e-07
transketolase; Provisional
Pssm-ID: 173383 [Multi-domain]
Cd Length: 661
Bit Score: 52.75
E-value: 9.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 76 NMDLERRIRSA IR WNAVMT V LR A SK kdlelg GH MASFQSS A TLYEVCFNHFFR a H N NN D ---- GG D - L V FFQ GH I S PGI Y 150
Cdd:PTZ00089 2 DGAIDEKCANE IR CLSADL V QK A NS ------ GH PGAPMGM A PIAHILWSEVMK - Y N PK D prwi NR D r F V LSN GH A S ALL Y 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 151 ARAF L E G R - L TE E QMN NFRQ E iggng L S SY P - HP K lmpd FWQF P T V SMGL GP I ----- NA IYQ A KFL K Y L D --- NR GLKD 220
Cdd:PTZ00089 75 SMLH L T G Y d L SM E DLK NFRQ L ----- G S RT P g HP E ---- RHIT P G V EVTT GP L gqgia NA VGL A IAE K H L A akf NR PGHP 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 221 TSAQR VY AFL GDG EMD E PE S KG A ITI A TRDK L DN L VFVINC N LQRL DG P -- VTGNGKIVNEL E GI fnga GW Q VI K V MW G D 298
Cdd:PTZ00089 146 IFDNY VY VIC GDG CLQ E GV S QE A LSL A GHLG L EK L IVLYDD N KITI DG N td LSFTEDVEKKY E AY ---- GW H VI E V DN G N 221
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 299 R wdellrkdtsgklvqlmnetldgdyqtfksrdgayvrehffnrypetaalvkdmtddeiwalnrggh D PKKVYA A FKK A 378
Cdd:PTZ00089 222 T ------------------------------------------------------------------- D FDGLRK A IEE A 234
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 379 QET KGKP TV I LAQ T IK GYG MGE ta E G KNIA H QV k KMNMDGVRHFRDQ F NV - P VADEQIEKLPYIT FE KDS E EY K YLH E RR 457
Cdd:PTZ00089 235 KKS KGKP KL I IVK T TI GYG SSK -- A G TEKV H GA - PLGDEDIAQVKEL F GL d P EKKFHVSEEVRQF FE QHV E KK K ENY E AW 311
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 458 QAL ggylparrstfdekldipa L A DFSQLLEEQSKE I STTIAFVRALNVML K NQSIKERLVP I IADE A RTFGMEG LF RQI 537
Cdd:PTZ00089 312 KKR ------------------- F A KYTAAFPKEAQA I ERRFKGELPPGWEK K LPKYTTNDKA I ATRK A SENVLNP LF QIL 372
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 538 GIYSPKGQQY TP QD ---- R E QVAYY K EDSK G QILQE G IN E -- LG A GSSWL AA ATSYSTNNLPMIP FY I Y ys MF G FQ R IGD 611
Cdd:PTZ00089 373 PELIGGSADL TP SN ltrp K E ANDFT K ASPE G RYIRF G VR E ha MC A IMNGI AA HGGFIPFGATFLN FY G Y -- AL G AV R LAA 450
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 612 L mwaagd QQARGFLI ggtsgr T T LNGE GL Q h EDG HS H -- IQS L T ---- I PN CISYD PA FAY E VAVIMQNG L ERMYGEK qe 685
Cdd:PTZ00089 451 L ------ SHHPVIYV ------ A T HDSI GL G - EDG PT H qp VET L A llra T PN LLVIR PA DGT E TSGAYALA L ANAKTPT -- 515
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491051468 686 nvyyy I TT L NEN y HM P AM P EGAE EG IR KG I Y KLASVEG S K g KVQ L LG SGS MMRHVR EAA DI LS A E 750
Cdd:PTZ00089 516 ----- I LC L SRQ - NT P PL P GSSI EG VL KG A Y IVVDFTN S P - QLI L VA SGS EVSLCV EAA KA LS K E 573
TktA
COG0021 Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway ...
225-409
7.81e-06
Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway/BioSystem: Pentose phosphate pathway
Pssm-ID: 439792 [Multi-domain]
Cd Length: 661
Bit Score: 49.62
E-value: 7.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 225 RV Y AFL GDG EMD E PE S KG A ITI A TRD KL DN L VFVINC N LQRL DG PV tgng KIV - N E - LEGI F NGA GW Q VI K V MW G drwde 302
Cdd:COG0021 148 YT Y VIA GDG DLM E GI S HE A ASL A GHL KL GK L IVLYDD N GISI DG DT ---- DLA f S E d VAKR F EAY GW H VI R V ED G ----- 218
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 303 llrkdtsgklvqlmnetldgdyqtfksrdgayvrehffnrypetaalvkdmtddeiwalnrgg HD PKKVY AA FKK A QETK 382
Cdd:COG0021 219 --------------------------------------------------------------- HD LEAID AA IEA A KAET 235
170 180
....*....|....*....|....*..
gi 491051468 383 G KPT V I LAQ TI K GYG MG e TAE G KNI AH 409
Cdd:COG0021 236 D KPT L I ICK TI I GYG SP - NKQ G TAK AH 261
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
570-678
9.11e-03
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 37.47
E-value: 9.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051468 570 GI N E LGAGSSWLAA A TSY stnnlp MI P FYIYYSM F g F Q R - IGDLMW A A gdqqargf LI G GTSGRTTLN G E G LQH EDG HS H 648
Cdd:smart00861 21 GI A E QAMVGFAAGL A LHG ------ LR P VVEIFFT F - F D R a KDQIRS A G -------- AS G NVPVVFRHD G G G GVG EDG PT H 85
90 100 110
....*....|....*....|....*....|....*..
gi 491051468 649 i Q S ------- LT IP NCISYD P AFAY E VAVIMQNGLER 678
Cdd:smart00861 86 - H S iedeall RA IP GLKVVA P SDPA E AKGLLRAAIRD 121
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
