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Conserved domains on  [gi|491051819|ref|WP_004913470|]
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MULTISPECIES: GNAT family N-acetyltransferase [Providencia]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
52-148 2.37e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 57.79  E-value: 2.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819  52 VDNEPVGFVQYYSNHENGRPEEVFIGQLMIDIKHQRKGFGSLAIPLVLDEIKSLGkyqsVSICYIEGNDMMKPFFEQFGF 131
Cdd:COG3153   46 DDGEIVGHVALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERG----ARAVVLLGDPSLLPFYERFGF 121

                         90       100
                 ....*....|....*....|.
gi 491051819 132 SVVDQDEF----DETIMRLVF 148
Cdd:COG3153  122 RPAGELGLtlgpDEVFLAKEL 142
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
52-148 2.37e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 57.79  E-value: 2.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819  52 VDNEPVGFVQYYSNHENGRPEEVFIGQLMIDIKHQRKGFGSLAIPLVLDEIKSLGkyqsVSICYIEGNDMMKPFFEQFGF 131
Cdd:COG3153   46 DDGEIVGHVALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERG----ARAVVLLGDPSLLPFYERFGF 121

                         90       100
                 ....*....|....*....|.
gi 491051819 132 SVVDQDEF----DETIMRLVF 148
Cdd:COG3153  122 RPAGELGLtlgpDEVFLAKEL 142
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 50-131 2.15e-07

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 46.74  E-value: 2.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819   50 IYVDNEPVGFVQYYSNHEngRPEEVFIGQLMIDIKHQRKGFGSLAIPLVLDEIKSLGkYQSVSICYIEGNDMMKPFFEQF 129
Cdd:pfam00583  38 AEEDGELVGFASLSIIDD--EPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERG-CERIFLEVAADNLAAIALYEKL 114


                  ..
gi 491051819  130 GF 131
Cdd:pfam00583 115 GF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 50-106 4.20e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.18  E-value: 4.20e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491051819  50 IYVDNEPVGFVQYYsnHENGRPEEVFIGQLMIDIKHQRKGFGSLAIPLVLDEIKSLG 106
Cdd:cd04301    4 AEDDGEIVGFASLS--PDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERG 58
PRK09831 PRK09831
GNAT family N-acetyltransferase;
52-136 1.65e-04

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 39.56  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819  52 VDNEPVGFVQYYSNHengrpeevfIGQLMIDIKHQRKGFGS-LAIPLVldeikslgkyQSVSICYIEGNDMMKPFFEQFG 130
Cdd:PRK09831  60 INAQPVGFITCIEHY---------IDMLFVDPEYTRRGVASaLLKPLI----------KSESELTVDASITAKPFFERYG 120


                 ....*.
gi 491051819 131 FSVVDQ 136
Cdd:PRK09831 121 FQTVKQ 126
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
52-148 2.37e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 57.79  E-value: 2.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819  52 VDNEPVGFVQYYSNHENGRPEEVFIGQLMIDIKHQRKGFGSLAIPLVLDEIKSLGkyqsVSICYIEGNDMMKPFFEQFGF 131
Cdd:COG3153   46 DDGEIVGHVALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERG----ARAVVLLGDPSLLPFYERFGF 121

                         90       100
                 ....*....|....*....|.
gi 491051819 132 SVVDQDEF----DETIMRLVF 148
Cdd:COG3153  122 RPAGELGLtlgpDEVFLAKEL 142
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 50-131 2.15e-07

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 46.74  E-value: 2.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819   50 IYVDNEPVGFVQYYSNHEngRPEEVFIGQLMIDIKHQRKGFGSLAIPLVLDEIKSLGkYQSVSICYIEGNDMMKPFFEQF 129
Cdd:pfam00583  38 AEEDGELVGFASLSIIDD--EPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERG-CERIFLEVAADNLAAIALYEKL 114


                  ..
gi 491051819  130 GF 131
Cdd:pfam00583 115 GF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
52-146 5.47e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 43.83  E-value: 5.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819  52 VDNEPVGFVQYYSNHENGRPEEVFIGQLMIDIKHQRKGFGSLAIPLVLDEIKSLGkYQSVSICYIEGNDMMKPFFEQFGF 131
Cdd:COG1247   59 EDGEVVGFASLGPFRPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARG-YRRLVAVVLADNEASIALYEKLGF 137

                         90       100
                 ....*....|....*....|....
gi 491051819 132 SVVDQDE---------FDETIMRL 146
Cdd:COG1247  138 EEVGTLPevgfkfgrwLDLVLMQK 161
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 20-136 7.55e-06

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 42.73  E-value: 7.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819  20 EITKEQEDFVALnSESIAAS-----KFFDYYINRGIYVDNEPVGFVQYysNHENGrpEEVFIGQLMIDIKHQRKGFGSLA 94
Cdd:COG0454    5 KATPEDINFILL-IEALDAElkameGSLAGAEFIAVDDKGEPIGFAGL--RRLDD--KVLELKRLYVLPEYRGKGIGKAL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 491051819  95 IPLVLDEIKSLGKYQSVSICYiEGNDMMKPFFEQFGFSVVDQ 136
Cdd:COG0454   80 LEALLEWARERGCTALELDTL-DGNPAAIRFYERLGFKEIER 120
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 22-141 9.50e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 42.67  E-value: 9.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819  22 TKEQEDFVALNSESIAASKFFDYYInrgIYVDNEPVGFVQYYSNHENgrpeEVFIGQLMIDIKHQRKGFGSLAIPLVLDE 101
Cdd:COG1246    8 PDDVPAILELIRPYALEEEIGEFWV---AEEDGEIVGCAALHPLDED----LAELRSLAVHPDYRGRGIGRRLLEALLAE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 491051819 102 IKSLGkyqsVSICYIEGNDMMKPFFEQFGFSVVDQDEFDE 141
Cdd:COG1246   81 ARELG----LKRLFLLTTSAAIHFYEKLGFEEIDKEDLPY 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 50-106 4.20e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.18  E-value: 4.20e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491051819  50 IYVDNEPVGFVQYYsnHENGRPEEVFIGQLMIDIKHQRKGFGSLAIPLVLDEIKSLG 106
Cdd:cd04301    4 AEDDGEIVGFASLS--PDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERG 58
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 58-138 6.36e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 39.64  E-value: 6.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819  58 GFVQYYSNHEngrPEEVFIGQLMIDIKHQRKGFGSLAIPLVLDEIKSLGkYQSVSICYIEGNDMMKPFFEQFGFSVVDQD 137
Cdd:COG0456    1 GFALLGLVDG---GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERG-ARRLRLEVREDNEAAIALYEKLGFEEVGER 76


                 .
gi 491051819 138 E 138
Cdd:COG0456   77 P 77
PRK09831 PRK09831
GNAT family N-acetyltransferase;
52-136 1.65e-04

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 39.56  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819  52 VDNEPVGFVQYYSNHengrpeevfIGQLMIDIKHQRKGFGS-LAIPLVldeikslgkyQSVSICYIEGNDMMKPFFEQFG 130
Cdd:PRK09831  60 INAQPVGFITCIEHY---------IDMLFVDPEYTRRGVASaLLKPLI----------KSESELTVDASITAKPFFERYG 120


                 ....*.
gi 491051819 131 FSVVDQ 136
Cdd:PRK09831 121 FQTVKQ 126
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 53-146 5.74e-04

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 38.06  E-value: 5.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819  53 DNEPVGFVQYYsnHENGRPEEVFIGqLMIDIKHQRKGFGSLAIPLVLDEIKSLGKYQSVSICYIEGNDMMKPFFEQFGF- 131
Cdd:COG1670   70 DGELIGVVGLY--DIDRANRSAEIG-YWLAPAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEKLGFr 146

                         90       100
                 ....*....|....*....|...
gi 491051819 132 --------SVVDQDEFDETIMRL 146
Cdd:COG1670  147 legtlrdaLVIDGRYRDHVLYSL 169
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 50-133 9.23e-04

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 36.28  E-value: 9.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491051819   50 IYVDNEPVGFVQYYSNHENGRPEEVFIgqlMIDIKHQRKGFGSLaiplVLDEIKSLGKYQSVSICYIEGNDMMKPFFEQF 129
Cdd:pfam13508   8 AEDDGKIVGFAALLPLDDEGALAELRL---AVHPEYRGQGIGRA----LLEAAEAAAKEGGIKLLELETTNRAAAFYEKL 80


                  ....
gi 491051819  130 GFSV 133
Cdd:pfam13508  81 GFEE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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