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Conserved domains on  [gi|491075153|ref|WP_004936775|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Enterobacterales]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
2-142 4.60e-42

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 136.45  E-value: 4.60e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491075153   2 YNIDDFDMKILTLLQANGRLTNQELSELVGLSASQCSRRRISLEQAQLIRGYHARLAPEAVGLGLVGLIEVSLithAQEQ 81
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV---PPHR 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491075153  82 IDSFHQMLEEVDAILDAYKTTGDADYLLKVAVADLPALSEFISQTLSPHKSVAHIKTAVVL 142
Cdd:COG1522   78 LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
2-142 4.60e-42

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 136.45  E-value: 4.60e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491075153   2 YNIDDFDMKILTLLQANGRLTNQELSELVGLSASQCSRRRISLEQAQLIRGYHARLAPEAVGLGLVGLIEVSLithAQEQ 81
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV---PPHR 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491075153  82 IDSFHQMLEEVDAILDAYKTTGDADYLLKVAVADLPALSEFISQTLSPHKSVAHIKTAVVL 142
Cdd:COG1522   78 LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-113 7.88e-31

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 107.22  E-value: 7.88e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491075153     4 IDDFDMKILTLLQANGRLTNQELSELVGLSASQCSRRRISLEQAQLIRGYHARLAPEAVGLGLVGLIEVSLitHAQEQID 83
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTL--ENPDKLE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 491075153    84 SFHQMLEEVDAILDAYKTTGDADYLLKVAV 113
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
4-151 3.31e-27

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 99.45  E-value: 3.31e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491075153   4 IDDFDMKILTLLQANGRLTNQELSELVGLSASQCSRRRISLEQAQLIRGYHARLAPEAVGLGLVGLIEVSLITHAQEQID 83
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491075153  84 SFHQMLEEVDAILDAYKTTGDADYLLKVAVADLPALSEFISQTLSPHKSVAHIKTAVVLNRIKENGLL 151
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRL 159
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 70-144 1.25e-16

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 69.86  E-value: 1.25e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491075153   70 IEVSLitHAQEQIDSFHQMLEEVDAILDAYKTTGDADYLLKVAVADLPALSEFISQTLSPHKSVAHIKTAVVLNR 144
Cdd:pfam01037   1 VEVKL--EPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-56 2.89e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 2.89e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 491075153   5 DDFDMKILTLLqANGRLTNQELSELVGLSASQCSRRRISLEQAQLIRGYHAR 56
Cdd:cd00090    6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG 56
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
2-142 4.60e-42

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 136.45  E-value: 4.60e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491075153   2 YNIDDFDMKILTLLQANGRLTNQELSELVGLSASQCSRRRISLEQAQLIRGYHARLAPEAVGLGLVGLIEVSLithAQEQ 81
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV---PPHR 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491075153  82 IDSFHQMLEEVDAILDAYKTTGDADYLLKVAVADLPALSEFISQTLSPHKSVAHIKTAVVL 142
Cdd:COG1522   78 LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-113 7.88e-31

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 107.22  E-value: 7.88e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491075153     4 IDDFDMKILTLLQANGRLTNQELSELVGLSASQCSRRRISLEQAQLIRGYHARLAPEAVGLGLVGLIEVSLitHAQEQID 83
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTL--ENPDKLE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 491075153    84 SFHQMLEEVDAILDAYKTTGDADYLLKVAV 113
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
4-151 3.31e-27

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 99.45  E-value: 3.31e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491075153   4 IDDFDMKILTLLQANGRLTNQELSELVGLSASQCSRRRISLEQAQLIRGYHARLAPEAVGLGLVGLIEVSLITHAQEQID 83
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491075153  84 SFHQMLEEVDAILDAYKTTGDADYLLKVAVADLPALSEFISQTLSPHKSVAHIKTAVVLNRIKENGLL 151
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRL 159
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 70-144 1.25e-16

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 69.86  E-value: 1.25e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491075153   70 IEVSLitHAQEQIDSFHQMLEEVDAILDAYKTTGDADYLLKVAVADLPALSEFISQTLSPHKSVAHIKTAVVLNR 144
Cdd:pfam01037   1 VEVKL--EPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
5-45 5.78e-12

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 56.61  E-value: 5.78e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 491075153    5 DDFDMKILTLLQANGRLTNQELSELVGLSASQCSRRRISLE 45
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
6-50 3.13e-09

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 49.74  E-value: 3.13e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 491075153    6 DFDMKILTLLQANGRLTNQELSELVGLSASQCSRRRISLEQAQLI 50
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-111 6.70e-09

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 51.63  E-value: 6.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491075153   1 MYNIDDFDMKILTLLQANGRLTNQELSELVGLSASQCSRRRISLEQAQLIRGYHARLAPEAVGLGLVGLIEVSLitHAQE 80
Cdd:PRK11179   4 NYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIIL--KSAK 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491075153  81 QIDSFHQMLEEVDAILDAYKTTGDADYLLKV 111
Cdd:PRK11179  82 DYPSALAKLESLDEVVEAYYTTGHYSIFIKV 112
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 3-51 1.07e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 36.04  E-value: 1.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 491075153   3 NIDDFDMKILTLLQAN-GRLTNQELSELVGLSASQCSRRRISLEQAQLIR 51
Cdd:COG2512   12 ELLEDERRVLELLRENgGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIE 61
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-56 2.89e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 2.89e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 491075153   5 DDFDMKILTLLqANGRLTNQELSELVGLSASQCSRRRISLEQAQLIRGYHAR 56
Cdd:cd00090    6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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